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5. List of Contributors

Author

Agrawal, Satish, primary, Aguilar, Cristobal, additional, Ahmad, Hafsa, additional, Arfin, Tanvir, additional, Arya, Abhishek, additional, Barba, Anna Angela, additional, Bayat, Mohammad, additional, Bhatia, Manish S., additional, Bhatia, Neela M., additional, Bigović, Dubravka, additional, Bochicchio, Sabrina, additional, Bolocan, Alexandra, additional, Boone-Villa, Daniel, additional, Bugarski, Branko, additional, Caccavo, Diego, additional, Cascone, Sara, additional, Chau, Ying, additional, Chifiriuc, Mariana Carmen, additional, Choudhari, Prafulla B., additional, Ciubuca, Bianca, additional, Cobos-Puc, Luis, additional, Dalmoro, Annalisa, additional, Deng, Lin, additional, Đorđević, Verica, additional, Dwivedi, Anil Kumar, additional, Feng, Teng, additional, Frăţiean, Diana, additional, Gaikwad, Vinod L., additional, Gheorghe, Irina, additional, Ghosh, Dipanjana, additional, Giri, Tapan Kumar, additional, Huang, Xiaonan, additional, Joseph, Emil, additional, Khan, Azhar U., additional, Khandelwal, Kiran, additional, Khosa, Archana, additional, Lamberti, Gaetano, additional, Lazar, Veronica, additional, Li, Linlin, additional, Liu, Zhirong, additional, Malik, Nazia, additional, Măruţescu, Luminiţa, additional, Nasri, Shima, additional, Ni, Rong, additional, Nikolić, Nada Ćujić, additional, Parasuraman, Paramanantham, additional, Pircalabioru, Gratiela G., additional, Postolache, Carmen, additional, Ramos-González, Rodolfo, additional, Saha, Ranendra Narayan, additional, Sandoval, José, additional, Šavikin, Katarina, additional, Saviuc, Crina, additional, Shrivastava, Tarani P., additional, Shukla, Tripti, additional, Siddhardha, Busi, additional, Silva-Belmares, Yesenia, additional, Singhvi, Gautam, additional, Suen, Wai Leung Langston, additional, Trifković, Kata, additional, Upmanyu, Neeraj, additional, Velázquez, Miguel, additional, and Ventura-Sobrevilla, Janeth, additional

Published
2019
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14. European contribution to the study of ROS:a summary of the findings and prospects for the future from the COST Action BM1203 (EU-ROS)

Author

Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Stella, Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–butuner, Bilge, Dias, Irundika, Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jinjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, Mcbean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Milos, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., di Lisa, Fabio, Daiber, Andreas, Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Stella, Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, João G., Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec–butuner, Bilge, Dias, Irundika, Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S., Fladmark, Kari E., Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jinjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, Mcbean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Milos, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T.N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-mañas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalçın, A. Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H.H.W., di Lisa, Fabio, and Daiber, Andreas

Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

Published
2017

15. European contribution to the study of ROS : A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Author

Egea, Javier, Fabregat, Isabel, Frapart, Yves M, Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G, Lopez, Manuela G, Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul J, Abbas, Kahina, Ademowo, Opeyemi S, Afonso, Catarina B, Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M, Barbosa, Rui M, Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P, Brito, Paula M, Carrara, Guia, Casas, Ana I, Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S, Costa, João G, Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec-Butuner, Bilge, Dias, Irundika H K, Dunn, Joe Dan, Edson, Amanda J, El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S, Fladmark, Kari E, Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen L, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A, Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J, Meredith, Stuart P, Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T N, Oelze, Matthias, Oliveira, Nuno G, Palmeira, Carlos M, Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G, Pitt, Andrew R, Poulsen, Henrik E, Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P, Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L, Soldati, Thierry, Sousa, Bebiana C, Spickett, Corinne M, Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A, Yalçın, A Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M, Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H H W, Di Lisa, Fabio, Daiber, Andreas, Egea, Javier, Fabregat, Isabel, Frapart, Yves M, Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G, Lopez, Manuela G, Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul J, Abbas, Kahina, Ademowo, Opeyemi S, Afonso, Catarina B, Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M, Barbosa, Rui M, Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P, Brito, Paula M, Carrara, Guia, Casas, Ana I, Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S, Costa, João G, Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec-Butuner, Bilge, Dias, Irundika H K, Dunn, Joe Dan, Edson, Amanda J, El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S, Fladmark, Kari E, Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen L, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A, Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J, Meredith, Stuart P, Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T N, Oelze, Matthias, Oliveira, Nuno G, Palmeira, Carlos M, Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G, Pitt, Andrew R, Poulsen, Henrik E, Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P, Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L, Soldati, Thierry, Sousa, Bebiana C, Spickett, Corinne M, Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A, Yalçın, A Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M, Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H H W, Di Lisa, Fabio, and Daiber, Andreas

Published
2017

16. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Author

MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Nefro Vasculaire Geneeskunde, Other research (not in main researchprogram), Egea, Javier, Fabregat, Isabel, Frapart, Yves M, Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G, Lopez, Manuela G, Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul J, Abbas, Kahina, Ademowo, Opeyemi S, Afonso, Catarina B, Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M, Barbosa, Rui M, Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P, Brito, Paula M, Carrara, Guia, Casas, Ana I, Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S, Costa, João G, Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec-Butuner, Bilge, Dias, Irundika H K, Dunn, Joe Dan, Edson, Amanda J, El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S, Fladmark, Kari E, Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen L, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A, Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J, Meredith, Stuart P, Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T N, Oelze, Matthias, Oliveira, Nuno G, Palmeira, Carlos M, Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G, Pitt, Andrew R, Poulsen, Henrik E, Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P, Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L, Soldati, Thierry, Sousa, Bebiana C, Spickett, Corinne M, Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A, Yalçın, A Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M, Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H H W, Di Lisa, Fabio, Daiber, Andreas, MS Nefrologie, Regenerative Medicine and Stem Cells, Circulatory Health, Nefro Vasculaire Geneeskunde, Other research (not in main researchprogram), Egea, Javier, Fabregat, Isabel, Frapart, Yves M, Ghezzi, Pietro, Görlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G, Lopez, Manuela G, Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vina, Jose, Winyard, Paul J, Abbas, Kahina, Ademowo, Opeyemi S, Afonso, Catarina B, Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M, Barbosa, Rui M, Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertrán, Esther, Bindoli, Alberto, Bottari, Serge P, Brito, Paula M, Carrara, Guia, Casas, Ana I, Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S, Costa, João G, Cuadrado, Antonio, My-Chan Dang, Pham, De Smet, Barbara, Debelec-Butuner, Bilge, Dias, Irundika H K, Dunn, Joe Dan, Edson, Amanda J, El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Péter, Fernandes, Ana S, Fladmark, Kari E, Förstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltán, Görbe, Anikó, Griffiths, Helen L, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustín, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Dürr, Pidder, Jaquet, Vincent, Joles, Jaap A, Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Korkmaz, Kemal Sami, Koziel, Rafal, Kračun, Damir, Krause, Karl-Heinz, Křen, Vladimír, Krieg, Thomas, Laranjinha, João, Lazou, Antigone, Li, Huige, Martínez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J, Meredith, Stuart P, Messens, Joris, Miguel, Verónica, Mikhed, Yuliya, Milisav, Irina, Milković, Lidija, Miranda-Vizuete, Antonio, Mojović, Miloš, Monsalve, María, Mouthuy, Pierre-Alexis, Mulvey, John, Münzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T N, Oelze, Matthias, Oliveira, Nuno G, Palmeira, Carlos M, Papaevgeniou, Nikoletta, Pavićević, Aleksandra, Pedre, Brandán, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G, Pitt, Andrew R, Poulsen, Henrik E, Prieto, Ignacio, Rigobello, Maria Pia, Robledinos-Antón, Natalia, Rodríguez-Mañas, Leocadio, Rolo, Anabela P, Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schröder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L, Soldati, Thierry, Sousa, Bebiana C, Spickett, Corinne M, Stancic, Ana, Stasia, Marie José, Steinbrenner, Holger, Stepanić, Višnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentová, Kateřina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A, Yalçın, A Suha, Yelisyeyeva, Olha, Žarković, Neven, Zatloukalová, Martina, Zielonka, Jacek, Touyz, Rhian M, Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H H W, Di Lisa, Fabio, and Daiber, Andreas

Published
2017

17. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Author

Egea, Javier, primary, Fabregat, Isabel, additional, Frapart, Yves M., additional, Ghezzi, Pietro, additional, Görlach, Agnes, additional, Kietzmann, Thomas, additional, Kubaichuk, Kateryna, additional, Knaus, Ulla G., additional, Lopez, Manuela G., additional, Olaso-Gonzalez, Gloria, additional, Petry, Andreas, additional, Schulz, Rainer, additional, Vina, Jose, additional, Winyard, Paul, additional, Abbas, Kahina, additional, Ademowo, Opeyemi S., additional, Afonso, Catarina B., additional, Andreadou, Ioanna, additional, Antelmann, Haike, additional, Antunes, Fernando, additional, Aslan, Mutay, additional, Bachschmid, Markus M., additional, Barbosa, Rui M., additional, Belousov, Vsevolod, additional, Berndt, Carsten, additional, Bernlohr, David, additional, Bertrán, Esther, additional, Bindoli, Alberto, additional, Bottari, Serge P., additional, Brito, Paula M., additional, Carrara, Guia, additional, Casas, Ana I., additional, Chatzi, Afroditi, additional, Chondrogianni, Niki, additional, Conrad, Marcus, additional, Cooke, Marcus S., additional, Costa, João G., additional, Cuadrado, Antonio, additional, My-Chan Dang, Pham, additional, De Smet, Barbara, additional, Debelec–Butuner, Bilge, additional, Dias, Irundika H.K., additional, Dunn, Joe Dan, additional, Edson, Amanda J., additional, El Assar, Mariam, additional, El-Benna, Jamel, additional, Ferdinandy, Péter, additional, Fernandes, Ana S., additional, Fladmark, Kari E., additional, Förstermann, Ulrich, additional, Giniatullin, Rashid, additional, Giricz, Zoltán, additional, Görbe, Anikó, additional, Griffiths, Helen, additional, Hampl, Vaclav, additional, Hanf, Alina, additional, Herget, Jan, additional, Hernansanz-Agustín, Pablo, additional, Hillion, Melanie, additional, Huang, Jingjing, additional, Ilikay, Serap, additional, Jansen-Dürr, Pidder, additional, Jaquet, Vincent, additional, Joles, Jaap A., additional, Kalyanaraman, Balaraman, additional, Kaminskyy, Danylo, additional, Karbaschi, Mahsa, additional, Kleanthous, Marina, additional, Klotz, Lars-Oliver, additional, Korac, Bato, additional, Korkmaz, Kemal Sami, additional, Koziel, Rafal, additional, Kračun, Damir, additional, Krause, Karl-Heinz, additional, Křen, Vladimír, additional, Krieg, Thomas, additional, Laranjinha, João, additional, Lazou, Antigone, additional, Li, Huige, additional, Martínez-Ruiz, Antonio, additional, Matsui, Reiko, additional, McBean, Gethin J., additional, Meredith, Stuart P., additional, Messens, Joris, additional, Miguel, Verónica, additional, Mikhed, Yuliya, additional, Milisav, Irina, additional, Milković, Lidija, additional, Miranda-Vizuete, Antonio, additional, Mojović, Miloš, additional, Monsalve, María, additional, Mouthuy, Pierre-Alexis, additional, Mulvey, John, additional, Münzel, Thomas, additional, Muzykantov, Vladimir, additional, Nguyen, Isabel T.N., additional, Oelze, Matthias, additional, Oliveira, Nuno G., additional, Palmeira, Carlos M., additional, Papaevgeniou, Nikoletta, additional, Pavićević, Aleksandra, additional, Pedre, Brandán, additional, Peyrot, Fabienne, additional, Phylactides, Marios, additional, Pircalabioru, Gratiela G., additional, Pitt, Andrew R., additional, Poulsen, Henrik E., additional, Prieto, Ignacio, additional, Rigobello, Maria Pia, additional, Robledinos-Antón, Natalia, additional, Rodríguez-Mañas, Leocadio, additional, Rolo, Anabela P., additional, Rousset, Francis, additional, Ruskovska, Tatjana, additional, Saraiva, Nuno, additional, Sasson, Shlomo, additional, Schröder, Katrin, additional, Semen, Khrystyna, additional, Seredenina, Tamara, additional, Shakirzyanova, Anastasia, additional, Smith, Geoffrey L., additional, Soldati, Thierry, additional, Sousa, Bebiana C., additional, Spickett, Corinne M., additional, Stancic, Ana, additional, Stasia, Marie José, additional, Steinbrenner, Holger, additional, Stepanić, Višnja, additional, Steven, Sebastian, additional, Tokatlidis, Kostas, additional, Tuncay, Erkan, additional, Turan, Belma, additional, Ursini, Fulvio, additional, Vacek, Jan, additional, Vajnerova, Olga, additional, Valentová, Kateřina, additional, Van Breusegem, Frank, additional, Varisli, Lokman, additional, Veal, Elizabeth A., additional, Yalçın, A. Suha, additional, Yelisyeyeva, Olha, additional, Žarković, Neven, additional, Zatloukalová, Martina, additional, Zielonka, Jacek, additional, Touyz, Rhian M., additional, Papapetropoulos, Andreas, additional, Grune, Tilman, additional, Lamas, Santiago, additional, Schmidt, Harald H.H.W., additional, Di Lisa, Fabio, additional, and Daiber, Andreas, additional

Published
2017
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19. NADPH oxidase-derived H 2 O 2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA

Author

Alvarez, Luis A., primary, Kovačič, Lidija, additional, Rodríguez, Javier, additional, Gosemann, Jan-Hendrik, additional, Kubica, Malgorzata, additional, Pircalabioru, Gratiela G., additional, Friedmacher, Florian, additional, Cean, Ada, additional, Ghişe, Alina, additional, Sărăndan, Mihai B., additional, Puri, Prem, additional, Daff, Simon, additional, Plettner, Erika, additional, von Kriegsheim, Alex, additional, Bourke, Billy, additional, and Knaus, Ulla G., additional

Published
2016
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20. Development and Biocompatibility Evaluation of Photocatalytic TiO2/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes.

Author

Nica, Ionela Cristina, Stan, Miruna S., Popa, Marcela, Chifiriuc, Mariana Carmen, Pircalabioru, Gratiela G., Lazar, Veronica, Dumitrescu, Iuliana, Diamandescu, Lucian, Feder, Marcel, Baibarac, Mihaela, Cernea, Marin, Maraloiu, Valentin Adrian, Popescu, Traian, and Dinischiotu, Anca

Subjects
GRAPHENE, PHOTOCATALYSTS, ANTI-infective agents, THERAPEUTICS
Abstract

Graphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO2, but the development of TiO2/graphene composites imposes the assessment of their risk to human and environmental health. Therefore, reduced graphene oxide was decorated with two types of TiO2 particles co-doped with 1% iron and nitrogen, one of them being obtained by a simultaneous precipitation of Ti3+ and Fe3+ ions to achieve their uniform distribution, and the other one after a sequential precipitation of these two cations for a higher concentration of iron on the surface. Physico-chemical characterization, photocatalytic efficiency evaluation, antimicrobial analysis and biocompatibility assessment were performed for these TiO2-based composites. The best photocatalytic efficiency was found for the sample with iron atoms localized at the sample surface. A very good anti-inhibitory activity was obtained for both samples against biofilms of Gram-positive and Gram-negative strains. Exposure of human skin and lung fibroblasts to photocatalysts did not significantly affect cell viability, but analysis of oxidative stress showed increased levels of carbonyl groups and advanced oxidation protein products for both cell lines after 48 h of incubation. Our findings are of major importance by providing useful knowledge for future photocatalytic self-cleaning and biomedical applications of graphene-based materials. [ABSTRACT FROM AUTHOR]

Published
2017
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21. Interaction of New-Developed TiO2-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts.

Author

Nica, Ionela Cristina, Stan, Miruna Silvia, Popa, Marcela, Chifiriuc, Mariana Carmen, Lazar, Veronica, Pircalabioru, Gratiela G., Dumitrescu, Iuliana, Ignat, Madalina, Feder, Marcel, Tanase, Liviu Cristian, Mercioniu, Ionel, Diamandescu, Lucian, and Dinischiotu, Anca

Subjects
TITANIUM dioxide, PHOTOCATALYSTS, NANOPARTICLES, OXIDATIVE stress, ANTI-infective agents
Abstract

TiO2-based photocatalysts were obtained during previous years in order to limit pollution and to ease human daily living conditions due to their special properties. However, obtaining biocompatible photocatalysts is still a key problem, and the mechanism of their toxicity recently received increased attention. Two types of TiO2 nanoparticles co-doped with 1% of iron and nitrogen (TiO2-1% Fe-N) atoms were synthesized in hydrothermal conditions at pH of 8.5 (HT1) and 5.5 (HT2), and thir antimicrobial activity and cytotoxic effects exerted on human pulmonary and dermal fibroblasts were assessed. These particles exhibited significant microbicidal and anti-biofilm activity, suggesting their potential application for microbial decontamination of different environments. In addition, our results demonstrated the biocompatibility of TiO2-1% Fe-N nanoparticles at low doses on lung and dermal cells, which may initiate oxidative stress through dose accumulation. Although no significant changes were observed between the two tested photocatalysts, the biological response was cell type specific and time- and dose-dependent; the lung cells proved to be more sensitive to nanoparticle exposure. Taken together, these experimental data provide useful information for future photocatalytic applications in the industrial, food, pharmaceutical, and medical fields. [ABSTRACT FROM AUTHOR]

Published
2017
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23. Innovative Self-Cleaning and Biocompatible Polyester Textiles Nano-Decorated with Fe-N-Doped Titanium Dioxide.

Author

Nica, Ionela Cristina, Stan, Miruna Silvia, Dinischiotu, Anca, Popa, Marcela, Chifiriuc, Mariana Carmen, Lazar, Veronica, Pircalabioru, Gratiela G., Bezirtzoglou, Eugenia, Iordache, Ovidiu G., Varzaru, Elena, Dumitrescu, Iuliana, Feder, Marcel, Vasiliu, Florin, Mercioniu, Ionel, and Diamandescu, Lucian

Subjects
POLYESTER fibers, PHOTOCATALYSTS, PSEUDOMONAS aeruginosa infections
Abstract

The development of innovative technologies to modify natural textiles holds an important impact for medical applications, including the prevention of contamination with microorganisms, particularly in the hospital environment. In our study, Fe and N co-doped TiO2 nanoparticles have been obtained via the hydrothermal route, at moderate temperature, followed by short thermal annealing at 400 °C. These particles were used to impregnate polyester (PES) materials which have been evaluated for their morphology, photocatalytic performance, antimicrobial activity against bacterial reference strains, and in vitro biocompatibility on human skin fibroblasts. Microscopic examination and quantitative assays have been used to evaluate the cellular morphology and viability, cell membrane integrity, and inflammatory response. All treated PES materials specifically inhibited the growth of Gram-negative bacilli strains after 15 min of contact, being particularly active against Pseudomonas aeruginosa. PES fabrics treated with photocatalysts did not affect cell membrane integrity nor induce inflammatory processes, proving good biocompatibility. These results demonstrate that the treatment of PES materials with TiO2-1% Fe-N particles could provide novel biocompatible fabrics with short term protection against microbial colonization, demonstrating their potential for the development of innovative textiles that could be used in biomedical applications for preventing patients' accidental contamination with microorganisms from the hospital environment. [ABSTRACT FROM AUTHOR]

Published
2016
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24. NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.

Author

Alvareza, Luis A., Kovačič, Lidija, Rodríguez, Javier, Gosemann, Jan-Hendrik, Kubica, Malgorzata, Pircalabioru, Gratiela G., Friedmacher, Florian, Cean, Ada, Ghisşe, Alina, Sărăndan, Mihai B., Puri, Prem, Daff, Simon, Plettner, Erika, Kriegsheim, Alex von, Bourke, Billy, and Knaus, Ulla G.

Subjects
NADPH oxidase, PHOSPHOTYROSINE, DRUG resistance, POLYSACCHARIDE synthesis, DOPA, REACTIVE oxygen species
Abstract

Strengthening the host immune system to fully exploit its potential as antimicrobial defense is vital in countering antibiotic resistance. Chemical compounds released during bidirectional host-pathogen cross-talk, which follows a sensing-response paradigm, can serve as protective mediators. A potent, diffusible messenger is hydrogen peroxide (H2O2), but its consequences on extracellular pathogens are unknown. Here we show that H2O2, released by the host on pathogen contact, subverts the tyrosine signaling network of a number of bacteria accustomed to low-oxygen environments. This defense mechanism uses heme-containing bacterial enzymes with peroxidase-like activity to facilitate phosphotyrosine (p-Tyr) oxidation. An intrabacterial reaction converts p-Tyr to protein-bound dopa (PB-DOPA) via a tyrosinyl radical intermediate, thereby altering antioxidant defense and inactivating enzymes involved in polysaccharide biosynthesis and metabolism. Disruption of bacterial signaling by DOPAmodification reveals an infection containment strategy that weakens bacterial fitness and could be a blueprint for antivirulence approaches. [ABSTRACT FROM AUTHOR]

Published
2016
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25. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Author

YALÇIN, AHMET SUHA, Egea, Javier, Fabregat, Isabel, Frapart, Yves M., Ghezzi, Pietro, Gorlach, Agnes, Kietzmann, Thomas, Kubaichuk, Kateryna, Knaus, Ulla G., Lopez, Manuela G., Olaso-Gonzalez, Gloria, Petry, Andreas, Schulz, Rainer, Vinal, Jose, Winyard, Paul, Abbas, Kahina, Ademowo, Opeyemi S., Afonso, Catarina B., Andreadou, Ioanna, Antelmann, Haike, Antunes, Fernando, Aslan, Mutay, Bachschmid, Markus M., Barbosa, Rui M., Belousov, Vsevolod, Berndt, Carsten, Bernlohr, David, Bertran, Esther, Bindoli, Alberto, Bottari, Serge P., Brito, Paula M., Carrara, Guia, Casas, Ana I., Chatzi, Afroditi, Chondrogianni, Niki, Conrad, Marcus, Cooke, Marcus S., Costa, Joao G., Cuadrado, Antonio, Dang, Pham My-Chan, De Smet, Barbara, Butuner, Bilge Debelec, Dias, Irundika H. K., Dunn, Joe Dan, Edson, Amanda J., El Assar, Mariam, El-Benna, Jamel, Ferdinandy, Peter, Fernandes, Ana S., Fladmark, Kari E., Forstermann, Ulrich, Giniatullin, Rashid, Giricz, Zoltan, Gorbe, Aniko, Griffiths, Helen, Hampl, Vaclav, Hanf, Alina, Herget, Jan, Hernansanz-Agustin, Pablo, Hillion, Melanie, Huang, Jingjing, Ilikay, Serap, Jansen-Durr, Pidder, Jaquet, Vincent, Joles, Jaap A., Kalyanaraman, Balaraman, Kaminskyy, Danylo, Karbaschi, Mahsa, Kleanthous, Marina, Klotz, Lars-Oliver, Korac, Bato, Sami Korkmaz, Kemal, Koziel, Rafal, Kracun, Damir, Krause, Karl-Heinz, Kren, Vladimir, Krieg, Thomas, Laranjinha, Joao, Lazou, Antigone, Li, Huige, Martinez-Ruiz, Antonio, Matsui, Reiko, McBean, Gethin J., Meredith, Stuart P., Messens, Joris, Miguel, Veronica, Mikhed, Yuliya, Milisav, Irina, Milkovic, Lidija, Miranda-Vizuete, Antonio, Mojovic, Milos, Monsalve, Maria, Mouthuy, Pierre-Alexis, Mulvey, John, Munzel, Thomas, Muzykantov, Vladimir, Nguyen, Isabel T. N., Oelze, Matthias, Oliveira, Nuno G., Palmeira, Carlos M., Papaevgeniou, Nikoletta, Pavicevic, Aleksandra, Pedre, Brandan, Peyrot, Fabienne, Phylactides, Marios, Pircalabioru, Gratiela G., Pitt, Andrew R., Poulsen, Henrik E., Prieto, Ignacio, Pia Rigobello, Maria, Robledinos-Anton, Natalia, Rodriguez-Manas, Leocadio, Rolo, Anabela P., Rousset, Francis, Ruskovska, Tatjana, Saraiva, Nuno, Sasson, Shlomo, Schroeder, Katrin, Semen, Khrystyna, Seredenina, Tamara, Shakirzyanova, Anastasia, Smith, Geoffrey L., Soldati, Thierry, Sousa, Bebiana C., Spickett, Corinne M., Stancic, Ana, Stasia, Marie Jose, Steinbrenner, Holger, Stepanic, Visnja, Steven, Sebastian, Tokatlidis, Kostas, Tuncay, Erkan, Turan, Belma, Ursini, Fulvio, Vacek, Jan, Vajnerova, Olga, Valentova, Katerina, Van Breusegem, Frank, Varisli, Lokman, Veal, Elizabeth A., Yalcin, A. Suha, Yelisyeyeva, Olha, Zarkovic, Neven, Zatloukalova, Martina, Zielonka, Jacek, Touyz, Rhian M., Papapetropoulos, Andreas, Grune, Tilman, Lamas, Santiago, Schmidt, Harald H. H. W., Di Lisa, Fabio, and Daiber, Andreas

Subjects
Redox therapeutics, PULMONARY ARTERIAL-HYPERTENSION, Redox signaling, GROWTH-FACTOR-BETA, Reactive nitrogen species, MICROCYSTIN-INDUCED APOPTOSIS, Antioxidants, MANGANESE SUPEROXIDE-DISMUTASE, CHRONIC GRANULOMATOUS-DISEASE, ENDOPLASMIC-RETICULUM STRESS, Oxidative stress, ENDOTHELIAL-CELL MIGRATION, ADENINE-DINUCLEOTIDE PHOSPHATE, NITRIC-OXIDE SYNTHASE, Reactive oxygen species, MITOCHONDRIAL OXIDATIVE STRESS
Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

Published
2017

26. Development and Biocompatibility Evaluation of Photocatalytic TiO₂/Reduced Graphene Oxide-Based Nanoparticles Designed for Self-Cleaning Purposes.

Author

Nica IC, Stan MS, Popa M, Chifiriuc MC, Pircalabioru GG, Lazar V, Dumitrescu I, Diamandescu L, Feder M, Baibarac M, Cernea M, Maraloiu VA, Popescu T, and Dinischiotu A

Abstract

Graphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO₂, but the development of TiO₂/graphene composites imposes the assessment of their risk to human and environmental health. Therefore, reduced graphene oxide was decorated with two types of TiO₂ particles co-doped with 1% iron and nitrogen, one of them being obtained by a simultaneous precipitation of Ti 3+ and Fe 3+ ions to achieve their uniform distribution, and the other one after a sequential precipitation of these two cations for a higher concentration of iron on the surface. Physico-chemical characterization, photocatalytic efficiency evaluation, antimicrobial analysis and biocompatibility assessment were performed for these TiO₂-based composites. The best photocatalytic efficiency was found for the sample with iron atoms localized at the sample surface. A very good anti-inhibitory activity was obtained for both samples against biofilms of Gram-positive and Gram-negative strains. Exposure of human skin and lung fibroblasts to photocatalysts did not significantly affect cell viability, but analysis of oxidative stress showed increased levels of carbonyl groups and advanced oxidation protein products for both cell lines after 48 h of incubation. Our findings are of major importance by providing useful knowledge for future photocatalytic self-cleaning and biomedical applications of graphene-based materials., Competing Interests: The authors declare no conflict of interest.

Published
2017
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27. Interaction of New-Developed TiO₂-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts.

Author

Nica IC, Stan MS, Popa M, Chifiriuc MC, Lazar V, Pircalabioru GG, Dumitrescu I, Ignat M, Feder M, Tanase LC, Mercioniu I, Diamandescu L, and Dinischiotu A

Subjects
Actin Cytoskeleton, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Antioxidants chemistry, Antioxidants pharmacology, Bacteria, Catalysis, Cell Survival drug effects, Colloids, Humans, Hydrodynamics, Lipid Peroxidation, Nanoparticles administration & dosage, Nanoparticles ultrastructure, Particle Size, Photoelectron Spectroscopy, X-Ray Diffraction, Fibroblasts metabolism, Fibroblasts microbiology, Nanoparticles chemistry, Photochemical Processes, Titanium chemistry
Abstract

TiO₂-based photocatalysts were obtained during previous years in order to limit pollution and to ease human daily living conditions due to their special properties. However, obtaining biocompatible photocatalysts is still a key problem, and the mechanism of their toxicity recently received increased attention. Two types of TiO₂ nanoparticles co-doped with 1% of iron and nitrogen (TiO₂-1% Fe-N) atoms were synthesized in hydrothermal conditions at pH of 8.5 (HT1) and 5.5 (HT2), and their antimicrobial activity and cytotoxic effects exerted on human pulmonary and dermal fibroblasts were assessed. These particles exhibited significant microbicidal and anti-biofilm activity, suggesting their potential application for microbial decontamination of different environments. In addition, our results demonstrated the biocompatibility of TiO₂-1% Fe-N nanoparticles at low doses on lung and dermal cells, which may initiate oxidative stress through dose accumulation. Although no significant changes were observed between the two tested photocatalysts, the biological response was cell type specific and time- and dose-dependent; the lung cells proved to be more sensitive to nanoparticle exposure. Taken together, these experimental data provide useful information for future photocatalytic applications in the industrial, food, pharmaceutical, and medical fields.

Published
2017
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28. Photocatalytic, Antimicrobial and Biocompatibility Features of Cotton Knit Coated with Fe-N-Doped Titanium Dioxide Nanoparticles.

Author

Stan MS, Nica IC, Dinischiotu A, Varzaru E, Iordache OG, Dumitrescu I, Popa M, Chifiriuc MC, Pircalabioru GG, Lazar V, Bezirtzoglou E, Feder M, and Diamandescu L

Abstract

Our research was focused on the evaluation of the photocatalytic and antimicrobial properties, as well as biocompatibility of cotton fabrics coated with fresh and reused dispersions of nanoscaled TiO₂-1% Fe-N particles prepared by the hydrothermal method and post-annealed at 400 °C. The powders were characterized by X-ray diffraction (XRD), Mössbauer spectroscopy and X-ray photoelectron spectroscopy. The textiles coated with doped TiO₂ were characterized by scanning electron microscopy and energy dispersive X-ray analyses, and their photocatalytic effect by trichromatic coordinates of the materials stained with methylene blue and coffee and exposed to UV, visible and solar light. The resulting doped TiO₂ consists of a mixture of prevailing anatase phase and a small amount (~15%-20%) of brookite, containing Fe 3+ and nitrogen. By reusing dispersions of TiO₂-1% Fe-N, high amounts of photocatalysts were deposited on the fabrics, and the photocatalytic activity was improved, especially under visible light. The treated fabrics exhibited specific antimicrobial features, which were dependent on their composition, microbial strain and incubation time. The in vitro biocompatibility evaluation on CCD-1070Sk dermal fibroblasts confirmed the absence of cytotoxicity after short-term exposure. These results highlight the potential of TiO₂-1% Fe-N nanoparticles for further use in the development of innovative self-cleaning and antimicrobial photocatalytic cotton textiles. However, further studies are required in order to assess the long-term skin exposure effects and the possible particle release due to wearing.

Published
2016
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