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2. Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis

Author

Sanges, Francesca, Floris, Matteo, Cossu-Rocca, Paolo, Muroni, Maria R., Pira, Giovanna, Urru, Silvana Anna Maria, Barrocu, Renata, Gallus, Silvano, Bosetti, Cristina, D’Incalci, Maurizio, Manca, Alessandra, Uras, Maria Gabriela, Medda, Ricardo, Sollai, Elisabetta, Murgia, Alma, Palmas, Dolores, Atzori, Francesco, Zinellu, Angelo, Cambosu, Francesca, Moi, Tiziana, Ghiani, Massimo, Marras, Vincenzo, Santona, Maria Cristina, Canu, Luisa, Valle, Enrichetta, Sarobba, Maria Giuseppina, Onnis, Daniela, Asunis, Anna, Cossu, Sergio, Orrù, Sandra, and De Miglio, Maria Rosaria

Published
2020
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5. Deciphering clinical significance of BCL11A isoforms and protein expression roles in triple-negative breast cancer subtype

Author

Angius, Andrea, primary, Pira, Giovanna, additional, Cossu-Rocca, Paolo, additional, Sotgiu, Giovanni, additional, Saderi, Laura, additional, Muroni, Maria Rosaria, additional, Virdis, Patrizia, additional, Piras, Daniela, additional, Vincenzo, Rallo, additional, Carru, Ciriaco, additional, Coradduzza, Donatella, additional, Uras, Maria Gabriela, additional, Cottu, Pierina, additional, Fancellu, Alessandro, additional, Orrù, Sandra, additional, Uva, Paolo, additional, and De Miglio, Maria Rosaria, additional

Published
2022
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6. Impact on breast cancer susceptibility and clinicopathological traits of common genetic polymorphisms in TP53, MDM2 and ATM genes in Sardinian women

Author

Floris, Matteo, primary, Pira, Giovanna, additional, Castiglia, Paolo, additional, Idda, Maria, additional, Steri, Maristella, additional, De Miglio, Maria, additional, Piana, Andrea, additional, Cossu, Andrea, additional, Azara, Antonio, additional, Arru, Caterina, additional, Deiana, Giovanna, additional, Putzu, Carlo, additional, Sanna, Valeria, additional, Carru, Ciriaco, additional, Serra, Antonello, additional, Bisail, Marco, additional, and Muroni, Maria, additional

Published
2022
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7. Metaproteomic Profile of the Colonic Luminal Microbiota From Patients With Colon Cancer

Author

Tanca, Alessandro, primary, Abbondio, Marcello, additional, Fiorito, Giovanni, additional, Pira, Giovanna, additional, Sau, Rosangela, additional, Manca, Alessandra, additional, Muroni, Maria Rosaria, additional, Porcu, Alberto, additional, Scanu, Antonio Mario, additional, Cossu-Rocca, Paolo, additional, De Miglio, Maria Rosaria, additional, and Uzzau, Sergio, additional

Published
2022
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8. Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia

Author

Malune, Paolo, primary, Piras, Giovanna, additional, Monne, Maria, additional, Fiamma, Maura, additional, Asproni, Rosanna, additional, Fancello, Tatiana, additional, Manai, Antonio, additional, Carta, Franco, additional, Pira, Giovanna, additional, Fancello, Patrizia, additional, Rosu, Valentina, additional, Uras, Antonella, additional, Mereu, Caterina, additional, Mameli, Giuseppe, additional, Lo Maglio, Iana, additional, Garau, Maria Cristina, additional, and Palmas, Angelo Domenico, additional

Published
2022
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9. Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAome

Author

Angius, Andrea, primary, Scanu, Antonio Mario, additional, Arru, Caterina, additional, Muroni, Maria Rosaria, additional, Rallo, Vincenzo, additional, Deiana, Giulia, additional, Ninniri, Maria Chiara, additional, Carru, Ciriaco, additional, Porcu, Alberto, additional, Pira, Giovanna, additional, Uva, Paolo, additional, Cossu-Rocca, Paolo, additional, and De Miglio, Maria Rosaria, additional

Published
2021
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12. Additional file 1 of Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis

Author

Sanges, Francesca, Floris, Matteo, Cossu-Rocca, Paolo, Muroni, Maria R., Pira, Giovanna, Urru, Silvana Anna Maria, Barrocu, Renata, Gallus, Silvano, Bosetti, Cristina, D’Incalci, Maurizio, Manca, Alessandra, Uras, Maria Gabriela, Medda, Ricardo, Sollai, Elisabetta, Murgia, Alma, Palmas, Dolores, Atzori, Francesco, Zinellu, Angelo, Cambosu, Francesca, Moi, Tiziana, Ghiani, Massimo, Marras, Vincenzo, Santona, Maria Cristina, Canu, Luisa, Valle, Enrichetta, Sarobba, Maria Giuseppina, Onnis, Daniela, Asunis, Anna, Cossu, Sergio, Orrù, Sandra, and Miglio, Maria Rosaria De

Abstract

Additional file 1: Figure S1. Violin plot of tumor size distribution according to “Triple Negative” breast cancer histologic types. Table S1. Correlation between tumor size and number of metastatic lymph nodes in different histologic types of “Triple Negative” breast cancer. Sardinia, Italy 1994–2015. Figure S2. Correlation between tumor size and number of positive lymph nodes in “Triple Negative” breast cancer histologic types. A linear regression model constructs the regression lines. The slope of the regression line symbolizes the average increase in the number of metastatic lymph nodes for each millimeter increase in tumor size for each histologic TNBC types, indicative of the influence of tumor size on number of metastatic lymph nodes.

Published
2020
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13. Multiple Signatures of the JC Polyomavirus in Paired Normal and Altered Colorectal Mucosa Indicate a Link with Human Colorectal Cancer, but Not with Cancer Progression

Author

Uleri, Elena, primary, Piu, Claudia, additional, Caocci, Maurizio, additional, Ibba, Gabriele, additional, Sanges, Francesca, additional, Pira, Giovanna, additional, Murgia, Luciano, additional, Barmina, Michele, additional, Giannecchini, Simone, additional, Porcu, Alberto, additional, Serra, Caterina, additional, Scanu, Antonio M, additional, De Miglio, Maria R, additional, and Dolei, Antonina, additional

Published
2019
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14. Integrated Analysis of miRNA and mRNA Endorses a Twenty miRNAs Signature for Colorectal Carcinoma

Author

Angius, Andrea, primary, Uva, Paolo, additional, Pira, Giovanna, additional, Muroni, Maria Rosaria, additional, Sotgiu, Giovanni, additional, Saderi, Laura, additional, Uleri, Elena, additional, Caocci, Maurizio, additional, Ibba, Gabriele, additional, Cesaraccio, Maria Rosaria, additional, Serra, Caterina, additional, Carru, Ciriaco, additional, Manca, Alessandra, additional, Sanges, Francesca, additional, Porcu, Alberto, additional, Dolei, Antonia, additional, Scanu, Antonio Mario, additional, Cossu Rocca, Paolo, additional, and De Miglio, Maria Rosaria, additional

Published
2019
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15. Additional file 1: Table S1. of Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

Author

Urru, Silvana, Gallus, Silvano, Bosetti, Cristina, Moi, Tiziana, Medda, Ricardo, Sollai, Elisabetta, Murgia, Alma, Sanges, Francesca, Pira, Giovanna, Manca, Alessandra, Palmas, Dolores, Floris, Matteo, Asunis, Anna, Atzori, Francesco, Carru, Ciriaco, D’Incalci, Maurizio, Ghiani, Massimo, Marras, Vincenzo, Onnis, Daniela, Santona, Maria, Sarobba, Giuseppina, Valle, Enrichetta, Canu, Luisa, Cossu, Sergio, Bulfone, Alessandro, Rocca, Paolo, Miglio, Maria De, and Orrù, Sandra

Abstract

Hazard ratios (HRs) of recurrence, and corresponding 95% confidence intervals (CIs), according to selected clinical and pathological characteristics, among 825 triple-negative breast cancers (TNBCs). Sardinia, Italy 1994-2015. Table S2. Hazard ratios (HRs) of recurrence, and corresponding 95% confidence intervals (CIs), according to pathological lymph nodes and lymph node ratio among 311 triple-negative breast cancers (TNBCs) with positive lymph nodes. Sardinia, Italy 1994-2015. Figure S1. Kaplan-Meir curves for disease-free survival according to tumor stage among 825 triple-negative breast cancer patients. Sardinia, Italy 1994â 2005. Figure S2. Kaplan-Meir curves for disease-free survival according to pathological lymph nodes stage (a) and lymph node ratio (b) among 311 triple-negative breast cancer patients with positive lymph nodes. Sardinia, Italy 1994â 2005 (DOC 658 kb)

Published
2018
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16. Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in breast cancer: a Sardinian preliminary case-control study

Author

Castiglia, Paolo, primary, Sanna, Valeria, additional, Azara, Antonio, additional, De Miglio, Maria R., additional, Murgia, Luciano, additional, Pira, Giovanna, additional, Sanges, Francesca, additional, Fancellu, Alessandro, additional, Carru, Ciriaco, additional, Bisail, Marco, additional, and Muroni, Maria Rosaria, additional

Published
2019
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17. MicroRNA-425-5p Expression Affects BRAF/RAS/MAPK Pathways In Colorectal Cancers

Author

Angius, Andrea, primary, Pira, Giovanna, additional, Scanu, Antonio Mario, additional, Uva, Paolo, additional, Sotgiu, Giovanni, additional, Saderi, Laura, additional, Manca, Alessandra, additional, Serra, Caterina, additional, Uleri, Elena, additional, Piu, Claudia, additional, Caocci, Maurizio, additional, Ibba, Gabriele, additional, Zinellu, Angelo, additional, Cesaraccio, Maria Rosaria, additional, Sanges, Francesca, additional, Muroni, Maria Rosaria, additional, Dolei, Antonina, additional, Cossu-Rocca, Paolo, additional, and De Miglio, Maria Rosaria, additional

Published
2019
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18. Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

Author

Urru, Silvana Anna Maria, primary, Gallus, Silvano, additional, Bosetti, Cristina, additional, Moi, Tiziana, additional, Medda, Ricardo, additional, Sollai, Elisabetta, additional, Murgia, Alma, additional, Sanges, Francesca, additional, Pira, Giovanna, additional, Manca, Alessandra, additional, Palmas, Dolores, additional, Floris, Matteo, additional, Asunis, Anna Maria, additional, Atzori, Francesco, additional, Carru, Ciriaco, additional, D’Incalci, Maurizio, additional, Ghiani, Massimo, additional, Marras, Vincenzo, additional, Onnis, Daniela, additional, Santona, Maria Cristina, additional, Sarobba, Giuseppina, additional, Valle, Enrichetta, additional, Canu, Luisa, additional, Cossu, Sergio, additional, Bulfone, Alessandro, additional, Rocca, Paolo Cossu, additional, De Miglio, Maria Rosaria, additional, and Orrù, Sandra, additional

Published
2018
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19. miRNA-135b Contributes to Triple Negative Breast Cancer Molecular Heterogeneity: Different Expression Profile in Basal-like Versus non-Basal-like Phenotypes

Author

Uva, Paolo, primary, Cossu-Rocca, Paolo, additional, Loi, Federica, additional, Pira, Giovanna, additional, Murgia, Luciano, additional, Orrù, Sandra, additional, Floris, Matteo, additional, Muroni, Maria Rosaria, additional, Sanges, Francesca, additional, Carru, Ciriaco, additional, Angius, Andrea, additional, and De Miglio, Maria Rosaria, additional

Published
2018
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20. EGFR kinase-dependent and kinase-independent roles in clear cell renal cell carcinoma

Author

Cossu-Rocca, Paolo, Muroni, Maria R, Sanges, Francesca, Sotgiu, Giovanni, Asunis, Anna, Tanca, Luciana, Onnis, Daniela, Pira, Giovanna, Manca, Alessandra, Dore, Simone, Uras, Maria G, Ena, Sara, and De Miglio, Maria R

Subjects
Original Article
Abstract

Epidermal growth factor receptor (EGFR) is associated with progression of many epithelial malignancies and represents a significant therapeutic target. Although clear cell renal cell carcinoma (CCRCC) has been widely investigated for EGFR molecular alterations, genetic evidences of EGFR gene activating mutations and/or gene amplification have been rarely confirmed in the literature. Therefore, until now EGFR-targeted therapies in clinical trials have been demonstrated unsuccessful. New evidence has been given about the interactions between EGFR and the sodium glucose co-transporter-1 (SGLT1) in maintaining the glucose basal intracellular level to favour cancer cell growth and survival; thus a new functional role may be attributed to EGFR, regardless of its kinase activity. To define the role of EGFR in CCRCC an extensive investigation of genetic changes and functional kinase activities was performed in a series of tumors by analyzing the EGFR mutational status and expression profile, together with the protein expression of downstream signaling pathways members. Furthermore, we investigated the co-expression of EGFR and SGLT1 proteins and their relationships with clinic-pathological features in CCRCC. EGFR protein expression was identified in 98.4% of CCRCC. Furthermore, it was described for the first time that SGLT1 is overexpressed in CCRCC (80.9%), and that co-expression with EGFR is appreciable in 79.4% of the tumours. Moreover, the activation of downstream EGFR pathways was found in about 79.4% of SGLT1-positive CCRCCs. The mutational status analysis of EGFR failed to demonstrate mutations on exons 18 to 24 and the presence of EGFR-variantIII (EGFRvIII) in all CCRCCs analyzed. FISH analysis revealed absence of EGFR amplification, and high polysomy of chromosome 7. Finally, the EGFR gene expression profile showed gene overexpression in 38.2% of CCRCCs. Our study contributes to define the complexity of EGFR role in CCRCC, identifying its bivalent kinase-dependent and kinase-independent functions, both potentially involved in CCRCC progression. These results might have important implications on therapeutic approaches to CCRCC, since the disruption of the interaction between EGFR/SGLT1, mediated by anti-EGFR antibodies and/or SGLT1 inhibitors, might constitute a novel therapeutic target for CCRCC treatment, and new clinical trials should be evaluated on the basis of this therapeutic proposal.

Published
2015

21. Continuing education: The original scientific article

Author

Spinelli, Osvaldo Mateo, Pira, Giovanna, Ena, Sara, Fittipaldi, Mónica Elsa, Ávila, Rodolfo Esteban, and Roselló, María Victoria

Subjects
Escritura/normas, Políticas Editoriales, publicaciones, Ciencias Médicas, Publicaciones periódicas, Edición/normas
Abstract

El artículo científico original proporciona un método para que los científicos puedan comunicarse con otros científicos sobre los resultados de sus investigaciones. El propósito de esta segunda parte de Educación Continua es dar una breve guía con consejos para ayudar al proceso de una mejor redacción científica y delinear los principios de la escritura y la edición. Escribir un artículo científico en una revista revisada por pares es un proceso exigente que requiere tiempo y habilidad. El artículo científico que informa sobre una investigación original incluye tres partes importantes: preliminares, cuerpo principal y parte final. El cuerpo principal debe seguir una estructura estándar resumido por el acrónimo IMRAD: Introducción, Métodos, Resultados y Discusión / conclusión. Cada sección tiene su propio estilo de la estructura y lenguaje de presentación. Se explica la importancia del empleo de tablas y figuras y se analizan otras secciones relevantes como la autoría, afiliación, conflicto de intereses y referencias., Scientific research articles provide a method for scientists to communicate with other scientists about the results of their research. The purpose of this second part of Continuing Education is to give a brief guide with tips to aid the process of better scientific writing and outline the principles of writing and publishing. Writing a scientific article in a peer-reviewed journal is a demanding process that requires time and skill. The paper reporting original research includes three important parts: preliminary, main body and final part. The main body should follow a standard structure summarized by the acronym IMRAD: Introduction, Methods, Results, and Discussion / Conclusion. Each section has its own style of structure and language of presentation. The significance of tables and figures is also explained and others relevant sections as authorship, affiliation, conflict of interest and references are also analyzed., Facultad de Ciencias Médicas

Published
2014

22. Analysis of PIK3CA Mutations and Activation Pathways in Triple Negative Breast Cancer

Author

Cossu-Rocca, Paolo, primary, Orrù, Sandra, additional, Muroni, Maria Rosaria, additional, Sanges, Francesca, additional, Sotgiu, Giovanni, additional, Ena, Sara, additional, Pira, Giovanna, additional, Murgia, Luciano, additional, Manca, Alessandra, additional, Uras, Maria Gabriela, additional, Sarobba, Maria Giuseppina, additional, Urru, Silvana, additional, and De Miglio, Maria Rosaria, additional

Published
2015
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24. Analysis of BCL11A gene Variants in Hematological Malignancies.

Author

Monne, Maria, primary, Piras, Giovanna, additional, Uras, Antonella, additional, Murineddu, Marco, additional, Palmas, Angelo D., additional, Pira, Giovanna, additional, Fancello, Maria Antonietta, additional, Latte, Gian Carlo, additional, Murgia, Alessandro, additional, Novelli, Angelo, additional, Deledda, Salvatore, additional, and Gabbas, Attilio, additional

Published
2009
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26. EGFR kinase-dependent and kinase-independent roles in clear cell renal cell carcinoma.

Author

Cossu-Rocca P, Muroni MR, Sanges F, Sotgiu G, Asunis A, Tanca L, Onnis D, Pira G, Manca A, Dore S, Uras MG, Ena S, and De Miglio MR

Abstract

Epidermal growth factor receptor (EGFR) is associated with progression of many epithelial malignancies and represents a significant therapeutic target. Although clear cell renal cell carcinoma (CCRCC) has been widely investigated for EGFR molecular alterations, genetic evidences of EGFR gene activating mutations and/or gene amplification have been rarely confirmed in the literature. Therefore, until now EGFR-targeted therapies in clinical trials have been demonstrated unsuccessful. New evidence has been given about the interactions between EGFR and the sodium glucose co-transporter-1 (SGLT1) in maintaining the glucose basal intracellular level to favour cancer cell growth and survival; thus a new functional role may be attributed to EGFR, regardless of its kinase activity. To define the role of EGFR in CCRCC an extensive investigation of genetic changes and functional kinase activities was performed in a series of tumors by analyzing the EGFR mutational status and expression profile, together with the protein expression of downstream signaling pathways members. Furthermore, we investigated the co-expression of EGFR and SGLT1 proteins and their relationships with clinic-pathological features in CCRCC. EGFR protein expression was identified in 98.4% of CCRCC. Furthermore, it was described for the first time that SGLT1 is overexpressed in CCRCC (80.9%), and that co-expression with EGFR is appreciable in 79.4% of the tumours. Moreover, the activation of downstream EGFR pathways was found in about 79.4% of SGLT1-positive CCRCCs. The mutational status analysis of EGFR failed to demonstrate mutations on exons 18 to 24 and the presence of EGFR-variantIII (EGFRvIII) in all CCRCCs analyzed. FISH analysis revealed absence of EGFR amplification, and high polysomy of chromosome 7. Finally, the EGFR gene expression profile showed gene overexpression in 38.2% of CCRCCs. Our study contributes to define the complexity of EGFR role in CCRCC, identifying its bivalent kinase-dependent and kinase-independent functions, both potentially involved in CCRCC progression. These results might have important implications on therapeutic approaches to CCRCC, since the disruption of the interaction between EGFR/SGLT1, mediated by anti-EGFR antibodies and/or SGLT1 inhibitors, might constitute a novel therapeutic target for CCRCC treatment, and new clinical trials should be evaluated on the basis of this therapeutic proposal.

Published
2015

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