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INTRODUCTION: Sertraline is a selective serotonin reuptake inhibitor which is often used as first-line treatment for depression. Several patterns of interstitial lung disease attributable to sertraline have been reported in the literature. CASE REPORT: A 69-year-old patient, who had been taking sertraline to treat severe depression for 10 months, presented with a deterioration in his general condition and respiratory symptoms found to be associated with bilateral pneumonitis. An exhaustive assessment did not reveal any infectious or autoimmune aetiology. Transthoracic lung biopsy revealed a pattern of eosinophilic lung disease. Sertraline-induced lung toxicity was then suspected and this treatment was therefore stopped. The patient's symptoms resolved and the chest imaging normalized. CONCLUSIONS: Our observation suggests that sertraline was the cause of chronic eosinophilic pneumonia characterized by an insidious clinical presentation several months after starting the medication. Given its widespread prescription, we encourage any clinician facing this disease to pay attention to possible drug-induced origins of lung disease. ispartof: REVUE DES MALADIES RESPIRATOIRES vol:38 issue:2 pages:210-214 ispartof: location:France status: published

Het hier beschreven onderzoek werd uitgevoerd in de proefboomgaard van PPO-Wageningen UR in Randwijk Daarvoor werd gebruik gemaakt van een volgroeid gewas Conference, waarop in 2012 een bemestingsproef was gestart waarbij de fosfaat- en stikstofgift werden gevarieerd. Op drie bemestingsregiems in die proef werd in 2013 en in 2014 het optreden van perenbladvlo gemeten. Op 13 juni 2013 had de behandeling N-hoog betrouwbaar meer perenbladvloeieren en -larven dan N-laag. N-middel was niet betrouwbaar verschillend van de beide andere behandelingen. De bemestingsbehandelingen hebben in de periode 2012 - 2014 geen verschil in productie tot gevolg gehad. Wel werd bij behandeling N-middel, die een grote fosfaat- (en stikstof-) bladbemesting kreeg, na lange bewaring een hogere hardheid vastgesteld. Dit kon worden verklaard door het effect van de fosfaatbladvoeding

International audience; Livestock systems are and will increasingly be impacted by climate change primarily because the feed supply produced on the farm (pastures, forage crops) depends greatly on the climatic conditions experienced. To adapt grassland-based livestock systems to climate change, some transformational redesign of the farming system may be required. Redesign is basically a matter of reconfiguring land-use for feed production and management practices set up to cope with weather variability. We present a participatory method to design systems adapted to new conditions. It is based on a pre-existing game-like platform (Forage Rummy) in which various year-round forage production and animal feeding requirements have to be assembled by participants with the support of a computerised support system. The weather scenario considered is conveyed by dedicated intermediary objects (e.g. herbage growth chart, rainfall chart) for a climatic year that is fully revealed before the design process starts. The solutions developed are then evaluated according to criteria of biophysical performance, organisational feasibility, and feeding shortage risks. The method consists of a sequence of three workshops (W) for which Forage Rummy was adapted. It keeps the complexity of the design problem manageable by progressively introducing the difficulties faced. W1 aims to produce a configuration that satisfies an average weather scenario of the future. W2 refines or possibly revises the previous configuration by considering between-year variability. W3 explicitly takes uncertainty about the weather into account. Unlike W1-2, in which entire weather scenarios are shown at the beginning, weather is only revealed month by month in W3. Experimental results of the use of the method with farmers are analysed, and further enhancements of the method are outlined.

International audience

Perinatal prognosis of pregnant drug abusers is better with intensive prenatal care and substitution maintenance programs. There is a large body of data in the literature on methadone (MTD), but very little on high-dose buprenorphine (HDB). The objective of this study was to compare 2 groups of pregnant women maintained on MTD or HDB for perinatal events. Study design. - Prospective multicentric study; all neonates (NN) whose mothers has been maintained during pregnancy on MTD or HDB were included by 34 French perinatal centers with specialized staff for care of these pregnant drug abusers. Results. - Two hundred and forty-six pregnant women were included: 93 (38%) MTD and 153 (62%) HDB. Social and perinatal data, prenatal care and factors correlated with poor prenatal care are reported. Forty-six percent of the pregnant women had good prenatal care; 88% had peridural analgesia; mean birthweight=2838g; mean gestational age=38.7 weeks; prematurity, Le pronostic périnatal des femmes enceintes et de leurs enfants est nettement amélioré par une prise en charge spécialisée et la prescription d'un traitement de substitution. De nombreuses données existent pour la méthadone (MTD) mais peu pour la buprénorphine haut-dosage (BHD). L'objectif de cette étude est de comparer 2 groupes de femmes enceintes substituées par MTD ou BHD. Méthode. - Étude prospective multicentrique incluant tous les nouveau-nés nés de mère substituée pendant la grossesse par MTD ou BHD dans 34 centres français du Groupe d'Études « Grossesse et Addictions » (GEGA) ayant une politique de prise en charge des femmes enceintes toxicomanes par une équipe pluridisciplinaire et en réseau ville-hôpital. Résultats. - Deux cent quarante-six femmes ont été incluses dont 93 (38 %) sous MTD et 153 (62 %) sous BHD. Les données sociales et périnatales, les conditions de suivi de la grossesse et les facteurs corrêlés à un mauvais suivi sont décrits. Globalement, 46 % des femmes ont été bien suivies ; 88 % ont bénéficié d'une analgésie péridurale ; poids de naissance moyen du nouveau-né = 2 838 g ; âge gestationnel moyen = 38,7 SA ; prématurité