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2. Comparing flow-based and anatomy-based features in the data-driven study of nasal pathologies

Author

Schillaci, Andrea, Hasegawa, Kazuto, Pipolo, Carlotta, Boracchi, Giacomo, and Quadrio, Maurizio

Subjects
Physics - Fluid Dynamics
Abstract

In several problems involving fluid flows, Computational Fluid Dynamics (CFD) provides detailed quantitative information, and often allows the designer to successfully optimize the system, by minimizing a cost function. Sometimes, however, one cannot improve the system with CFD alone, because a suitable cost function is not readily available: one notable example is diagnosis in medicine. The field of interest considered here is rhinology: a correct air flow is key for the functioning of the human nose, yet the notion of a functionally normal nose is not available, and a cost function cannot be written. An alternative and attractive pathway to diagnosis and surgery planning is offered by data-driven methods. In this work, we consider the machine-learning study of nasal pathologies caused by anatomic malformations, with the aim of understanding whether fluid dynamic features, available after a CFD analysis, are more effective than purely geometric features in the training of a neural network for regression. Our experiments are carried out on an extremely simplified anatomic model and a correspondingly simple CFD approach; nevertheless, they demonstrate that flow-based features perform better than geometry-based ones, and allow the training of a neural network with fewer inputs, a crucial advantage in fields like medicine., Comment: Submitted to Flow

Published
2023

5. Multidisciplinary Decision-Making—ITAlian Consensus After Two Years of Real Practice on the Management of Severe Uncontrolled CRSwNP by Biologics (ITACA Study)

Author

De Corso, Eugenio, Pipolo, Carlotta, Caminati, Marco, Cantone, Elena, Seccia, Veronica, Cecchi, Lorenzo, Nettis, Eustachio, Garzaro, Massimiliano, Ottaviano, Giancarlo, Gelardi, Matteo, Cavaliere, Carlo, Heffler, Enrico, Pagella, Fabio, Pasquini, Ernesto, Trimarchi, Matteo, Gallo, Stefania, La Mantia, Ignazio, Torretta, Sara, Mattavelli, Davide, Caruso, Cristiano, Matucci, Andrea, Vultaggio, Alessandra, Bellocchi, Gianluca, Alicandri Ciufelli, Matteo, FM, Passali, and Senna, Gianenrico

Published
2024
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11. Pediatric Odontogenic Sinusitis: A Systematic Review

Author

Rosso, Cecilia, primary, Urbanelli, Anastasia, additional, Spoldi, Chiara, additional, Felisati, Giovanni, additional, Pecorari, Giancarlo, additional, Pipolo, Carlotta, additional, Nava, Nicolò, additional, and Saibene, Alberto Maria, additional

Published
2024
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13. Remission in Type 2 Inflammatory Diseases: Current Evidence, Unmet Needs, and Suggestions for Defining Remission in Chronic Rhinosinusitis with Nasal Polyps

Author

Caminati, Marco, primary, De Corso, Eugenio, additional, Ottaviano, Giancarlo, additional, Pipolo, Carlotta, additional, Schiappoli, Michele, additional, Seccia, Veronica, additional, Spinelli, Francesca Romana, additional, Savarino, Edoardo Vincenzo, additional, Gisondi, Paolo, additional, and Senna, Gianenrico, additional

Published
2023
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14. Influence of Prior Endoscopic Sinus Surgery Extent on Dupilumab Effectiveness in CRSwNP Patients.

Author

Alicandri‐Ciufelli, Matteo, Marchioni, Daniele, Pipolo, Carlotta, Garzaro, Massimiliano, Nitro, Letizia, Dell'Era, Valeria, Ferrella, Francesco, Campagnoli, Massimo, Russo, Paolo, Galloni, Costanza, Ghidini, Angelo, De Corso, Eugenio, and Lucidi, Daniela

Abstract

Background: Guidelines recommend that the vast majority of patients with severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) should have at least one endoscopic sinus surgery (ESS) prior to starting biologics. Because ESS can be performed with a variable extension, the aim of this study would be to evaluate the association between surgical extensiveness, as measured by ACCESS score, and outcomes collected in patients treated with Dupilumab. Materials and Methods: This is a multicentric retrospective study; patients affected by CRSwNP who were subjected to Dupilumab therapy and who underwent at least one ESS prior to Dupilumab initiation were included. ACCESS score was assigned to each patient's pre‐Dupilumab CT scan. Subjective and objective parameters (SNOT‐22, NPS, VAS scores, Sniffin' Sticks) were collected before and during the administration of therapy. Statistical correlations between ACCESS scores and clinical outcomes were investigated. Results: A total of 145 patients were included; mean time from last previous ESS was 68.6 months, and on average, patients were subjected to 2.2 surgeries. Many correlations with ACCESS scores were demonstrated: better NPS at all timepoints and subjective scores (30‐days SNOT‐22, VAS nasal obstruction, and rhinorrhea) were achieved in patients with low ACCESS score (more extensive ESS). On the other hand, significantly worse VAS loss of smell values were demonstrated in patients with lower ACCESS scores. Conclusion: Dupilumab patients subjected to a prior extensive ESS may have reduced size of polyps and improved subjective indicators, together with a decreased chance to recover smell, when compared with patients who underwent a minimal excision. Level of Evidence: 3 Laryngoscope, 134:1556–1563, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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15. Raccomandazioni pratiche nella gestione ambulatoriale della rinosinusite cronica con poliposi nasale severa, nell’era dei biologici

Author

De Corso, Eugenio, primary, Pipolo, Carlotta, additional, Cantone, Elena, additional, Ottaviano, Giancarlo, additional, Gallo, Stefania, additional, Trimarchi, Matteo, additional, Torretta, Sara, additional, Cavaliere, Carlo, additional, Lucidi, Daniela, additional, Seccia, Veronica, additional, Settimi, Stefano, additional, Canevari, Frank Rikki Mauritz, additional, Pasquini, Ernesto, additional, La Mantia, Ignazio, additional, Garzaro, Massimiliano, additional, Bellocchi, Gianluca, additional, De Benedetto, Michele, additional, Lombardo, Nicola, additional, Macchi, Alberto, additional, Malvezzi, Luca, additional, Motta, Gaetano, additional, Vicini, Claudio, additional, Maselli, Alessandro, additional, Dell’Era, Valeria, additional, Dragonetti, Alberto, additional, Asprea, Francesco, additional, Lupato, Valentina, additional, Ghidini, Angelo, additional, Masieri, Simonetta, additional, Mattavelli, Davide, additional, Salzano, Francesco Antonio, additional, Passali, Desiderio, additional, Galli, Jacopo, additional, and Pagella, Fabio, additional

Published
2023
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16. Diagnostic therapeutic assistance pathway (PDTA) of type 2 chronic rhinosinusitis

Author

Canevari, Frank Rikki, primary, Giorli, Alessia, additional, Monti, Giulia, additional, Biagini, Cesare, additional, Bagnasco, Diego, additional, Cavaliere, Carlo, additional, Pipolo, Carlotta, additional, De Corso, Eugenio, additional, Gelardi, Matteo, additional, Gramellini, Giulia, additional, Ioppi, Alessandro, additional, La Mantia, Ignazio, additional, Malvezzi, Luca, additional, Bignami, Maurizio, additional, Dehgani-Mobaraki, Puya, additional, Seccia, Veronica, additional, Maggiore, Giandomenico, additional, and Macchi, Alberto, additional

Published
2023
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17. Intraoperative Neuromonitoring Does Not Reduce the Risk of Temporary and Definitive Recurrent Laryngeal Nerve Damage during Thyroid Surgery: A Systematic Review and Meta-Analysis of Endoscopic Findings from 73,325 Nerves at Risk

Author

Cozzi, Anna Teresa, primary, Ottavi, Alice, additional, Lozza, Paolo, additional, Maccari, Alberto, additional, Borloni, Roberto, additional, Nitro, Letizia, additional, Felisati, Elena Giulia, additional, Alliata, Andrea, additional, Martino, Barbara, additional, Cacioppo, Giancarlo, additional, Fuccillo, Manuela, additional, Rosso, Cecilia, additional, Pipolo, Carlotta, additional, Felisati, Giovanni, additional, De Pasquale, Loredana, additional, and Saibene, Alberto Maria, additional

Published
2023
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20. Long COVID in Children: A Multidisciplinary Review

Author

Sansone, Francesco, primary, Pellegrino, Giulia Michela, additional, Caronni, Antonio, additional, Bonazza, Federica, additional, Vegni, Elena, additional, Lué, Alberto, additional, Bocci, Tommaso, additional, Pipolo, Carlotta, additional, Giusti, Giuliano, additional, Di Filippo, Paola, additional, Di Pillo, Sabrina, additional, Chiarelli, Francesco, additional, Sferrazza Papa, Giuseppe Francesco, additional, and Attanasi, Marina, additional

Published
2023
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21. Practical recommendations for managing severe chronic rhinosinusitis with nasal polyps in the era of biologics

Author

De Corso, Eugenio, Pipolo, Carlotta, Cantone, Elena, Ottaviano, Giancarlo, Gallo, Stefania, Trimarchi, Matteo, Torretta, Sara, Cavaliere, Carlo, Lucidi, Daniela, Seccia, Veronica, Settimi, Stefano, Canevari, Frank Rikki Mauritz, Pasquini, Ernesto, La Mantia, Ignazio, Garzaro, Massimiliano, Bellocchi, Gianluca, De Benedetto, Michele, Lombardo, Nicola, Macchi, Alberto, Malvezzi, Luca, Motta, Gaetano, Vicini, Claudio, Maselli, Alessandro, Dell'Era, Valeria, Dragonetti, Alberto, Asprea, Francesco, Lupato, Valentina, Ghidini, Angelo, Masieri, Simonetta, Mattavelli, Davide, Salzano, Francesco Antonio, Passali, Desiderio, Galli, Jacopo, Pagella, Fabio, De Corso, Eugenio, Pipolo, Carlotta, Cantone, Elena, Ottaviano, Giancarlo, Gallo, Stefania, Trimarchi, Matteo, Torretta, Sara, Cavaliere, Carlo, Lucidi, Daniela, Seccia, Veronica, Settimi, Stefano, Canevari, Frank Rikki Mauritz, Pasquini, Ernesto, La Mantia, Ignazio, Garzaro, Massimiliano, Bellocchi, Gianluca, De Benedetto, Michele, Lombardo, Nicola, Macchi, Alberto, Malvezzi, Luca, Motta, Gaetano, Vicini, Claudio, Maselli, Alessandro, Dell'Era, Valeria, Dragonetti, Alberto, Asprea, Francesco, Lupato, Valentina, Ghidini, Angelo, Masieri, Simonetta, Mattavelli, Davide, Salzano, Francesco Antonio, Passali, Desiderio, Galli, Jacopo, and Pagella, Fabio

Subjects
chronic rhinosinusiti, Type 2 inflammation, practical recommendation, biologic, nasal polyp
Abstract

Objective: We conducted a national survey to understand how rhinology practice has changed with the advent of biologics and how this affected patients with uncontrolled, severe chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to analyse the results of the survey and infer practical recommendations for clinical practice. Methods: A group of ear, nose, and throat specialists (ENTs) experienced in the management of CRSwNP developed a 74-question survey. ENTs from rhinology centres authorised to prescribe biologics in the context of the national health system were invited to answer it between 01/05/2022 and 31/07/2022. The responses underwent descriptive analyses, and the authors discussed the results and derived practical recommendations for clinical practice. Results: ENTs working in rhinology centres changed their practices coinciding with the advent of biologics. CRSwNP evaluations have become more complex because they involve diagnostic confirmation, determining the patients' immunologic profile, and other factors. We observed heterogenous behaviours in practice that may be conditioned by the novelty of the topic. The results of the survey were used to develop practical recommendations for ENTs and are summarised herein. Conclusions: Clinical practice in rhinology outpatient clinics has changed profoundly in the era of biologics. Our practical recommendations for clinicians working in rhinology centres are expected to help standardise practice and improve care.

Published
2023

23. Nasal Cytology on 241 Children: From Birth to the First 3 Years of Life and Association with Common Airways Diseases

Author

Rosso, Cecilia, primary, Turati, Federica, additional, Saibene, Alberto Maria, additional, Verduci, Elvira, additional, Fuccillo, Emanuela, additional, Tavilla, Maria Chiara, additional, Magnani, Mauro, additional, Banderali, Giuseppe, additional, Ferraroni, Monica, additional, De Corso, Eugenio, additional, Felisati, Giovanni, additional, and Pipolo, Carlotta, additional

Published
2023
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24. Long COVID in Children: A Multidisciplinary Review

Author

Sansone, Francesco, Pellegrino, Giulia Michela, Caronni, Antonio, Bonazza, Federica, Vegni, Elena, Lué, Alberto, Bocci, Tommaso, Pipolo, Carlotta, Giusti, Giuliano, Di Filippo, Paola, Di Pillo, Sabrina, Chiarelli, Francesco, Sferrazza Papa, Giuseppe Francesco, Attanasi, Marina, Sansone, Francesco, Pellegrino, Giulia Michela, Caronni, Antonio, Bonazza, Federica, Vegni, Elena, Lué, Alberto, Bocci, Tommaso, Pipolo, Carlotta, Giusti, Giuliano, Di Filippo, Paola, Di Pillo, Sabrina, Chiarelli, Francesco, Sferrazza Papa, Giuseppe Francesco, and Attanasi, Marina

Abstract

Long COVID syndrome has emerged as a long-lasting consequence of acute SARS-CoV-2 infection in adults. In addition, children may be affected by Long COVID, with potential clinical issues in different fields, including problems in school performance and daily activities. Yet, the pathophysiologic bases of Long COVID in children are largely unknown, and it is difficult to predict who will develop the syndrome. In this multidisciplinary clinical review, we summarise the latest scientific data regarding Long COVID and its impact on children. Special attention is given to diagnostic tests, in order to help the physicians to find potential disease markers and quantify impairment. Specifically, we assess the respiratory, upper airways, cardiac, neurologic and motor and psychological aspects. Finally, we also propose a multidisciplinary clinical approach.

Published
2023

26. Chronic Rhinosinusitis with Nasal Polyps: A Survey on Routine Management and Evaluation of Disease Control in Practice.

Author

De Corso, Eugenio, Ottaviano, Giancarlo, Pipolo, Carlotta, Cantone, Elena, Mattavelli, Davide, Alicandri-Ciufelli, Matteo, Lucidi, Daniela, Caminati, Marco, Senna, Gianenrico, Cavaliere, Carlo, Ghidini, Angelo, Gallo, Stefania, Macchi, Alberto, Torretta, Sara, Seccia, Veronica, Garzaro, Massimiliano, Fadda, Gian Luca, Trimarchi, Matteo, Pasquini, Ernesto, and Pagella, Fabio

Subjects
NASAL polyps, DISEASE management, PREVENTIVE medicine, PHYSICIANS' attitudes, SINUSITIS, PATIENTS' attitudes
Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with a significant impact on quality of life. The overall goal of CRSwNP management, as with other chronic conditions, is to achieve "disease control", and for that reason, a definition of control of disease is pivotal in deciding the best treatment strategy. Although many staging systems have already been developed to evaluate the disease, disease control is not yet to be standardized, and a specific tool that is consistently applied and accepted by all practitioners is still missing in daily clinical practice. To gain an overview of the implementation and limitations of existing guidelines and to shed light on real-life definitions of control and disease severity, we conducted a nationwide survey of otorhinolaryngologists routinely treating CRSwNP to identify unmet clinical needs in Italy. The results showed homogeneous responses regarding the knowledge contained in international guidelines while highlighting the difficulty of their implementation in day-to-day practice. Respondents called attention to the importance of clinical symptoms, giving more weight to the patient's perspective. Among the symptoms to be considered, respondents emphasized nasal obstruction, followed by loss of sense of smell and rhinorrhea. Others also believe that the physician's perspective should be considered, and the inclusion of endoscopy as a measure of control was warranted by many. The need for a specific tool that is able to unequivocally ascertain disease control is increasingly pivotal in this new era of biologics for treating CRSwNP. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): A multicentric observational Phase IV real‐life study (DUPIREAL).

Author

De Corso, Eugenio, Pasquini, Ernesto, Trimarchi, Matteo, La Mantia, Ignazio, Pagella, Fabio, Ottaviano, Giancarlo, Garzaro, Massimiliano, Pipolo, Carlotta, Torretta, Sara, Seccia, Veronica, Cantone, Elena, Ciofalo, Andrea, Lucidi, Daniela, Fadda, Gian Luca, Pafundi, Pia Clara, Settimi, Stefano, Montuori, Claudio, Anastasi, Francesca, Pagliuca, Giulio, and Ghidini, Angelo

Subjects
NASAL tumors, NASAL polyps, DUPILUMAB, SINUSITIS, DISEASE complications, QUALITY of life, COMORBIDITY
Abstract

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with significant morbidity and reduced health‐related quality of life. Findings from clinical trials have demonstrated the effectiveness of dupilumab in CRSwNP, although real‐world evidence is still limited. Methods: This Phase IV real‐life, observational, multicenter study assessed the effectiveness and safety of dupilumab in patients with severe uncontrolled CRSwNP (n = 648) over the first year of treatment. We collected data at baseline and after 1, 3, 6, 9, and 12 months of follow‐up. We focused on nasal polyps score (NPS), symptoms, and olfactory function. We stratified outcomes by comorbidities, previous surgery, and adherence to intranasal corticosteroids, and examined the success rates based on current guidelines, as well as potential predictors of response at each timepoint. Results: We observed a significant decrease in NPS from a median value of 6 (IQR 5–6) at baseline to 1.0 (IQR 0.0–2.0) at 12 months (p <.001), and a significant decrease in Sino‐Nasal Outcomes Test‐22 (SNOT‐22) from a median score of 58 (IQR 49–70) at baseline to 11 (IQR 6–21; p <.001) at 12 months. Sniffin' Sticks scores showed a significant increase over 12 months (p <.001) compared to baseline. The results were unaffected by concomitant diseases, number of previous surgeries, and adherence to topical steroids, except for minor differences in rapidity of action. An excellent‐moderate response was observed in 96.9% of patients at 12 months based on EPOS 2020 criteria. Conclusions: Our findings from this large‐scale real‐life study support the effectiveness of dupilumab as an add‐on therapy in patients with severe uncontrolled CRSwNP in reducing polyp size and improving the quality of life, severity of symptoms, nasal congestion, and smell. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps): a multicentric observational phase IV real‐life study (DUPIREAL)

Author

De Corso Eugenio, Pasquini, Ernesto, Trimarchi, Matteo, La Mantia Ignazio, Pagella, Fabio, Ottaviano, Giancarlo, Garzaro, Massimiliano, Pipolo, Carlotta, Torretta, Sara, Seccia, Veronica, Cantone, Elena, Ciofalo, Andrea, Lucidi, Daniela, Fadda Gian Luca, Pafundi Pia Clara, Settimi, Stefano, Montuori, Claudio, Anastasi, Francesca, Pagliuca, Giulio, Ghidini, Angelo, Cavaliere, Carlo, Maffei, Marianna, Bussu, Francesco, Gallo, Stefania, Canevari Frank Rikki Mauritz, Paludetti, Gaetano, Galli, Jacopo, Spanu, Camilla, Porru Davide Paolo, Lo Verde Simone, Corbò, Marco, Cantiani, Alessandro, Furno, Daniela, D’Agostino, Giuseppe, D’Auria Leandro Maria, De Maio Gabriele, Di Bella Giuseppe Alberto, Penazzi, Daniele, Mele Dario Antonio, Di Cesare Tiziana, Andrea, Rampi, Umberto, Tanzini, Saccardo, Tommaso, Roccuzzo, Giuseppe, Cipolla, Federica, Ragusa, Martina, Grigaliute, Egle, Alicandri Ciufelli Matteo, Roncadi, Leonardo, Rizzo, Davide, De Vita Carla, Farneti, Paolo, Todero, Gabriella, Cristofani‐mencacci, Lodovica, Statuti, Erica, Cavallo, Giovanni, Urbanelli, Anastasia, Ferrella, Francesco, Arnone, Flavio, Di Nola Claudio, Pignataro, Lorenzo, Nava, Nicolò, Russo, Paolo, Savastano, Vincenzo, Masieri, Simonetta, Dell’Era, Valeria, Aluffi Valletti Paolo, Sovardi, Fabio, Siragusa, Vera, Clemenzi, Veronica, Stolfa, Andrea, Simoni, Edi, and Astolfi, Laura

Subjects
dupilumab, smell, biologics, dupireal, crswnp, asthma, biologics, chronic rhinosinusitis with nasal polyps, dupilumab, smell, asthma, chronic rhinosinusitis with nasal polyps
Published
2023

32. Implementation of Routine Endoscopy with Narrow Band Imaging in the Evaluation of Oral and Upper Airways Lesions in Oral Chronic Graft-Versus-Host Disease: A Preliminary Study

Author

Nitro, Letizia, primary, Pipolo, Carlotta, additional, Castellarin, Paolo, additional, Sardella, Andrea, additional, Bulfamante, Antonio Mario, additional, De Marco, Beatrice, additional, Magliano, Gabriele, additional, Grillo, Giovanni, additional, Felisati, Giovanni, additional, and Saibene, Alberto Maria, additional

Published
2022
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35. Advanced Differentiated Thyroid Cancer: A Complex Condition Needing a Tailored Approach

Author

Bulfamante, Antonio Mario, primary, Lori, Eleonora, additional, Bellini, Maria Irene, additional, Bolis, Elisa, additional, Lozza, Paolo, additional, Castellani, Luca, additional, Saibene, Alberto Maria, additional, Pipolo, Carlotta, additional, Fuccillo, Emanuela, additional, Rosso, Cecilia, additional, Felisati, Giovanni, additional, and De Pasquale, Loredana, additional

Published
2022
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36. Conversion rates in robotic thyroid surgery: A systematic review and meta‐analysis

Author

Martino, Barbara, primary, Nitro, Letizia, additional, De Pasquale, Loredana, additional, Lozza, Paolo, additional, Maccari, Alberto, additional, Castellani, Luca, additional, Piazzoni, Matilde, additional, Cardellicchio, Matteo, additional, Bulfamante, Antonio Mario, additional, Pipolo, Carlotta, additional, Felisati, Giovanni, additional, and Saibene, Alberto Maria, additional

Published
2022
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38. Survey on Use of Local and Systemic Corticosteroids in the Management of Chronic Rhinosinusitis with Nasal Polyps Identification of Unmet Clinical Needs

Author

De Corso, Eugenio, Pipolo, Carlotta, Cantone, Elena, Ottaviano, Giancarlo, Gallo, Stefania, Rikki Mauritz Canevari, Frank, De Macchi, Alberto, Monti, Giulia, Cavaliere, Carlo, La Mantia, Ignazio, Torretta, Sara, Bussu, Francesco, Scarano, Emanuele, Petrone, Paolo, Ghidini, Angelo, Lucidi, Daniela, Garzaro, Massimiliano, Trimarchi, Matteo, Seccia, Veronica, Passali, Giulio Cesare, Salsi, Daria, Cuda, Domenico, Pasquini, Ernesto, Malvezzi, Luca, Settimi, Stefano, Paludetti, Gaetano, Galli, Jacopo, Eugenio De Corso, Alberto Macchi, Francesco Bussu (ORCID:0000-0001-6261-2772), Emanuele Scarano (ORCID:0000-0003-2570-1121), Giulio Cesare Passali (ORCID:0000-0002-8176-0962), Stefano Settimi (ORCID:0000-0003-0104-1501), Gaetano Paludetti (ORCID:0000-0003-2480-1243), Jacopo Galli (ORCID:0000-0001-6353-6249), De Corso, Eugenio, Pipolo, Carlotta, Cantone, Elena, Ottaviano, Giancarlo, Gallo, Stefania, Rikki Mauritz Canevari, Frank, De Macchi, Alberto, Monti, Giulia, Cavaliere, Carlo, La Mantia, Ignazio, Torretta, Sara, Bussu, Francesco, Scarano, Emanuele, Petrone, Paolo, Ghidini, Angelo, Lucidi, Daniela, Garzaro, Massimiliano, Trimarchi, Matteo, Seccia, Veronica, Passali, Giulio Cesare, Salsi, Daria, Cuda, Domenico, Pasquini, Ernesto, Malvezzi, Luca, Settimi, Stefano, Paludetti, Gaetano, Galli, Jacopo, Eugenio De Corso, Alberto Macchi, Francesco Bussu (ORCID:0000-0001-6261-2772), Emanuele Scarano (ORCID:0000-0003-2570-1121), Giulio Cesare Passali (ORCID:0000-0002-8176-0962), Stefano Settimi (ORCID:0000-0003-0104-1501), Gaetano Paludetti (ORCID:0000-0003-2480-1243), and Jacopo Galli (ORCID:0000-0001-6353-6249)

Abstract

Background: Local and systemic corticosteroids have long been the workhorse in management of chronic rhinosinusitis with nasal polyps (CRSwNP), although there is no universally accepted modality of prescription. We carried out a survey in Italy to capture current trends in the use of topical and systemic corticosteroids in patients with CRSwNP. Methods: A survey was set up on Survey Monkey®. Each author distributed the link to the survey in an ad hoc manner and a total of 437 participants filled out the survey. Results: Mometasone furoate (79.3%) was the most frequently prescribed, administered daily by 61.9% of participants; the remaining preferred to discontinue treatment for brief periods to reduce side effects or to modulate the therapy in mild cases. The majority believe that a short cycle of systemic steroids should be prescribed for re-exacerbation of symptoms and that the number of cycles in the previous year should be evaluated to define control of the disease even if international guidelines do not provide clear indications on this topic. A certain degree of divergence emerged from responses regarding how long and the maximal dose of systemic steroids which place patients at high risk for adverse events. Finally, systemic corticosteroids seem to offer only temporary benefit on recovery of smell without guaranteeing long-term control even if the patient is adherent to topical corticosteroids. Conclusions: Our results highlight the need for clear guidelines on oral steroids, which could help supporting the use of a precision medicine approach, including indications for new biological agents.

Published
2022

39. Survey on Use of Local and Systemic Corticosteroids in the Management of Chronic Rhinosinusitis with Nasal Polyps: Identification of Unmet Clinical Needs

Author

De Corso, Eugenio, primary, Pipolo, Carlotta, additional, Cantone, Elena, additional, Ottaviano, Giancarlo, additional, Gallo, Stefania, additional, Canevari, Frank Rikki Mauritz, additional, Macchi, Alberto, additional, Monti, Giulia, additional, Cavaliere, Carlo, additional, La Mantia, Ignazio, additional, Torretta, Sara, additional, Bussu, Francesco, additional, Scarano, Emanuele, additional, Petrone, Paolo, additional, Ghidini, Angelo, additional, Lucidi, Daniela, additional, Garzaro, Massimiliano, additional, Trimarchi, Matteo, additional, Seccia, Veronica, additional, Passali, Giulio Cesare, additional, Salsi, Daria, additional, Cuda, Domenico, additional, Pasquini, Ernesto, additional, Malvezzi, Luca, additional, Settimi, Stefano, additional, Paludetti, Gaetano, additional, and Galli, Jacopo, additional

Published
2022
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40. Evidence of SARS-CoV-2 in nasal brushings and olfactory mucosa biopsies of COVID-19 patients

Author

Pipolo, Carlotta, primary, Bottai, Daniele, additional, Fuccillo, Emanuela, additional, Aronica, Eleonora, additional, Bruschi, Fabio, additional, Bulfamante, Antonio Mario, additional, Castellani, Luca, additional, Canevini, Maria Paola, additional, Chiumello, Davide, additional, Ferrari, Sergio, additional, Martinelli, Carla, additional, Muttini, Stefano, additional, Priori, Alberto, additional, Saibene, Alberto Maria, additional, Spoldi, Chiara, additional, Tosi, Delfina, additional, Zanusso, Gianluigi, additional, Bulfamante, Gaetano Pietro, additional, and Felisati, Giovanni, additional

Published
2022
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48. Adenoidectomy for middle ear disease in cleft palate children: a systematic review

Author

Rosso, Cecilia, primary, Bulfamante, Antonio Mario, additional, Pipolo, Carlotta, additional, Fuccillo, Emanuela, additional, Maccari, Alberto, additional, Lozza, Paolo, additional, Scotti, Alberto, additional, Pisani, Antonia, additional, Castellani, Luca, additional, De Donato, Giuseppe, additional, Tavilla, Maria Chiara, additional, Portaleone, Sara Maria, additional, Felisati, Giovanni, additional, and Saibene, Alberto Maria, additional

Published
2021
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