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24 results on '"Piombino, Claudia"'

2. Author Correction: Clinical impact of drug-drug interactions on abemaciclib in the real-world experience of AB-ITALY study

Author

Scagnoli, Simone, Pisegna, Simona, Toss, Angela, Caputo, Roberta, De Laurentiis, Michelino, Palleschi, Michela, de Giorgi, Ugo, Cortesi, Enrico, Fabbri, Agnese, Fabi, Alessandra, Paris, Ida, Orlandi, Armando, Curigliano, Giuseppe, Criscitiello, Carmen, Garrone, Ornella, Tomasello, Gianluca, D’Auria, Giuliana, Vici, Patrizia, Ricevuto, Enrico, Domati, Federica, Piombino, Claudia, Parola, Sara, Scafetta, Roberta, Cirillo, Alessio, Taurelli Salimbeni, Beatrice, Di Lisa, Francesca Sofia, Strigari, Lidia, Preissner, Robert, Simmaco, Maurizio, Santini, Daniele, Marchetti, Paolo, and Botticelli, Andrea

Published
2024
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3. Clinical impact of drug-drug interactions on abemaciclib in the real-world experience of AB-ITALY study

Author

Scagnoli, Simone, Pisegna, Simona, Toss, Angela, Caputo, Roberta, De Laurentiis, Michelino, Palleschi, Michela, de Giorgi, Ugo, Cortesi, Enrico, Fabbri, Agnese, Fabi, Alessandra, Paris, Ida, Orlandi, Armando, Curigliano, Giuseppe, Criscitiello, Carmen, Garrone, Ornella, Tomasello, Gianluca, D’Auria, Giuliana, Vici, Patrizia, Ricevuto, Enrico, Domati, Federica, Piombino, Claudia, Parola, Sara, Scafetta, Roberta, Cirillo, Alessio, Taurelli Salimbeni, Beatrice, Di Lisa, Francesca Sofia, Strigari, Lidia, Preissner, Robert, Simmaco, Maurizio, Santini, Daniele, Marchetti, Paolo, and Botticelli, Andrea

Published
2024
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4. Homologous Recombination Repair Deficiency in Metastatic Prostate Cancer: New Therapeutic Opportunities.

Author

Piombino, Claudia, Pipitone, Stefania, Tonni, Elena, Mastrodomenico, Luciana, Oltrecolli, Marco, Tchawa, Cyrielle, Matranga, Rossana, Roccabruna, Sara, D'Agostino, Elisa, Pirola, Marta, Bacchelli, Francesca, Baldessari, Cinzia, Baschieri, Maria Cristina, Dominici, Massimo, Sabbatini, Roberto, and Vitale, Maria Giuseppa

Subjects
*HOMOLOGOUS recombination, *DNA repair, *PROSTATE cancer, *METASTASIS, *ANDROGEN receptors, *CLINICAL trials, *LUTEINIZING hormone releasing hormone
Abstract

More than 20% of metastatic prostate cancer carries genomic defects involving DNA damage repair pathways, mainly in homologous recombination repair-related genes. The recent approval of olaparib has paved the way to precision medicine for the treatment of metastatic prostate cancer with PARP inhibitors in this subset of patients, especially in the case of BRCA1 or BRCA2 pathogenic/likely pathogenic variants. In face of this new therapeutic opportunity, many issues remain unsolved. This narrative review aims to describe the relationship between homologous recombination repair deficiency and prostate cancer, the techniques used to determine homologous recombination repair status in prostate cancer, the crosstalk between homologous recombination repair and the androgen receptor pathway, the current evidence on PARP inhibitors activity in metastatic prostate cancer also in homologous recombination repair-proficient tumors, as well as emerging mechanisms of resistance to PARP inhibitors. The possibility of combination therapies including a PARP inhibitor is an attractive option, and more robust data are awaited from ongoing phase II and phase III trials outlined in this manuscript. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Predictive factors for relapse in triple-negative breast cancer patients without pathological complete response after neoadjuvant chemotherapy

Author

Toss, Angela, primary, Venturelli, Marta, additional, Civallero, Monica, additional, Piombino, Claudia, additional, Domati, Federica, additional, Ficarra, Guido, additional, Combi, Francesca, additional, Cabitza, Eleonora, additional, Caggia, Federica, additional, Barbieri, Elena, additional, Barbolini, Monica, additional, Moscetti, Luca, additional, Omarini, Claudia, additional, Piacentini, Federico, additional, Tazzioli, Giovanni, additional, Dominici, Massimo, additional, and Cortesi, Laura, additional

Published
2022
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13. Circulating and Intracellular miRNAs as Prognostic and Predictive Factors in HER2-Positive Early Breast Cancer Treated with Neoadjuvant Chemotherapy: A Review of the Literature

Author

Isca, Chrystel, primary, Piacentini, Federico, additional, Mastrolia, Ilenia, additional, Masciale, Valentina, additional, Caggia, Federica, additional, Toss, Angela, additional, Piombino, Claudia, additional, Moscetti, Luca, additional, Barbolini, Monica, additional, Maur, Michela, additional, Dominici, Massimo, additional, and Omarini, Claudia, additional

Published
2021
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15. Clinicopathologic Profile of Breast Cancer in Germline ATM and CHEK2 Mutation Carriers

Author

Toss, Angela, primary, Tenedini, Elena, additional, Piombino, Claudia, additional, Venturelli, Marta, additional, Marchi, Isabella, additional, Gasparini, Elisa, additional, Barbieri, Elena, additional, Razzaboni, Elisabetta, additional, Domati, Federica, additional, Caggia, Federica, additional, Grandi, Giovanni, additional, Combi, Francesca, additional, Tazzioli, Giovanni, additional, Dominici, Massimo, additional, Tagliafico, Enrico, additional, and Cortesi, Laura, additional

Published
2021
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17. The Prognostic and Predictive Role of Somatic BRCA Mutations in Ovarian Cancer: Results from a Multicenter Cohort Study

Author

Toss, Angela, primary, Piombino, Claudia, additional, Tenedini, Elena, additional, Bologna, Alessandra, additional, Gasparini, Elisa, additional, Tarantino, Vittoria, additional, Filieri, Maria Elisabetta, additional, Cottafavi, Luca, additional, Giovanardi, Filippo, additional, Madrigali, Stefano, additional, Civallero, Monica, additional, Marcheselli, Luigi, additional, Marchi, Isabella, additional, Domati, Federica, additional, Venturelli, Marta, additional, Barbieri, Elena, additional, Grandi, Giovanni, additional, Tagliafico, Enrico, additional, and Cortesi, Laura, additional

Published
2021
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19. Lifestyle Intervention on Body Weight and Physical Activity in Patients with Breast Cancer can reduce the Risk of Death in Obese Women: The EMILI Study

Author

Cortesi, Laura, Sebastiani, Federica, Iannone, Anna, Marcheselli, Luigi, Venturelli, Marta, Piombino, Claudia, Toss, Angela, and Federico, Massimo

Subjects
obesity, breast cancer, overall survival, BMI loss, physical activity, Breast cancer, Diet, Obesity, Overall survival, Physical activity, diet, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Article
Abstract

Background obesity and sedentary lifestyle have been shown to negatively affect survival in breast cancer (BC). The purpose of this study was to test the efficacy of a lifestyle intervention on body mass index (BMI) and physical activity (PA) levels among BC survivors in Modena, Italy, in order to show an outcome improvement in obese and overweight patients. Methods: This study is a single-arm experimental design, conducted between November 2009 and May 2016 on 430 women affected by BC. Weight, BMI, and PA were assessed at baseline, at 12 months, and at the end of the study. Survival curves were estimated among normal, overweight, and obese patients. Results: Mean BMI decreased from baseline to the end of the study was equal to 2.9% (p = 0.065) in overweight patients and 3.3% in obese patients (p = 0.048). Mean PA increase from baseline to the end of the study was equal to 125% (p < 0.001) in normal patients, 200% (p < 0.001) in overweight patients and 100% (p < 0.001) in obese patients. After 70 months of follow-up, the 5-year overall survival (OS) rate was 96%, 96%, and 93%, respectively in normal, obese, and overweight patients. Overweight patients had significantly worse OS than normal ones (HR = 3.69, 95%CI = 1.82–4.53 p = 0.027) whereas no statistically significant differences were seen between obese and normal patients (HR 2.45, 95%CI = 0.68–8.78, p = 0.169). Conclusions: A lifestyle intervention can lead to clinically meaningful weight loss and increase PA in patients with BC. These results could contribute to improving the OS in obese patients compared to overweight ones.

Published
2020

21. Secondary Prevention in Hereditary Breast and/or Ovarian Cancer Syndromes Other Than BRCA

Author

Piombino, Claudia, Cortesi, Laura, Lambertini, Matteo, Punie, Kevin, Grandi, Giovanni, and Toss, Angela

Subjects
endocrine system diseases, Article Subject, skin and connective tissue diseases, female genital diseases and pregnancy complications
Abstract

BRCA1- and BRCA2-associated hereditary breast and ovarian cancer syndromes are among the best-known and most extensively studied hereditary cancer syndromes. Nevertheless, many patients who proved negative at BRCA genetic testing bring pathogenic mutations in other suppressor genes and oncogenes associated with hereditary breast and/or ovarian cancers. These genes include TP53 in Li–Fraumeni syndrome, PTEN in Cowden syndrome, mismatch repair (MMR) genes in Lynch syndrome, CDH1 in diffuse gastric cancer syndrome, STK11 in Peutz–Jeghers syndrome, and NF1 in neurofibromatosis type 1 syndrome. To these, several other genes can be added that act jointly with BRCA1 and BRCA2 in the double-strand break repair system, such as PALB2, ATM, CHEK2, NBN, BRIP1, RAD51C, and RAD51D. Management of primary and secondary cancer prevention in these hereditary cancer syndromes is crucial. In particular, secondary prevention by screening aims to discover precancerous lesions or cancers at their initial stages because early detection could allow for effective treatment and a full recovery. The present review aims to summarize the available literature and suggest proper screening strategies for hereditary breast and/or ovarian cancer syndromes other than BRCA.

Published
2020
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23. The prognostic role of somatic BRCA mutations in ovarian cancer: Preliminary results from an observational multicenter cohort study.

Author

Piombino, Claudia, primary, Toss, Angela, additional, Bologna, Alessandra, additional, Gasparini, Elisa, additional, Tarantino, Vittoria, additional, Filieri, Maria Elisabetta, additional, Cottafavi, Luca, additional, Giovanardi, Filippo, additional, Marcheselli, Luigi, additional, Marchi, Isabella, additional, Domati, Federica, additional, Venturelli, Marta, additional, Barbieri, Elena, additional, Grandi, Giovanni, additional, Tenedini, Elena, additional, Tagliafico, Enrico, additional, and Cortesi, Laura, additional

Published
2020
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24. BRCA Detection Rate in an Italian Cohort of Luminal Early-Onset and Triple-Negative Breast Cancer Patients without Family History: When Biology Overcomes Genealogy

Author

Toss, Angela, primary, Molinaro, Eleonora, additional, Venturelli, Marta, additional, Domati, Federica, additional, Marcheselli, Luigi, additional, Piana, Simonetta, additional, Barbieri, Elena, additional, Grandi, Giovanni, additional, Piombino, Claudia, additional, Marchi, Isabella, additional, Tenedini, Elena, additional, Tagliafico, Enrico, additional, Tazzioli, Giovanni, additional, and Cortesi, Laura, additional

Published
2020
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