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1. Deferasirox film‐coated tablet‐associated ulcerative colitis: An emerging pattern in thalassemia patients?

Author

Piolatto, Andrea, primary, Gaglioti, Carmen Maria, additional, Tesio, Nicolò, additional, Clemente, Maria Grazia, additional, Culcasi, Martina, additional, Matrone, Alessio, additional, Pila, Maria Paola, additional, Sambataro, Angela, additional, Longo, Filomena, additional, Origa, Raffaella, additional, and Ferrero, Giovanni Battista, additional

Published
2024
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5. Reply to “Hepatocellular carcinoma in thalassemia and other hemoglobinopathies”

Author

Origa, Raffaella, primary, Gianesin, Barbara, additional, Longo, Filomena, additional, Di Maggio, Rosario, additional, Cassinerio, Elena, additional, Gamberini, Maria Rita, additional, Pinto, Valeria Maria, additional, Casale, Maddalena, additional, La Nasa, Giorgio, additional, Caocci, Giovanni, additional, Piroddi, Antonio, additional, Piolatto, Andrea, additional, Di Mauro, Alessandra, additional, Romano, Claudia, additional, Gigante, Antonia, additional, Barella, Susanna, additional, Maggio, Aurelio, additional, Graziadei, Giovanna, additional, Perrotta, Silverio, additional, and Forni, Gian Luca, additional

Published
2023
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6. Alterations of Neuromuscular Environment Are Associated with Chronic Tissue Hypoxia in β-Thalassemia Patients

Author

Piolatto, Andrea, primary, Boccia, Gennaro, additional, Manca, Alessandra, additional, Gaglioti, Carmen, additional, Ceglie, Teresa, additional, Cosentino, Caterina, additional, Beratto, Luca, additional, Cusato, Jessica, additional, Falco, Patrizia, additional, De Carlo, Silvia, additional, Longo, Filomena, additional, Roetto, Antonella, additional, Piga, Antonio, additional, D'Avolio, Antonio, additional, Rainoldi, Alberto, additional, and Ferrero, Giovanni Battista, additional

Published
2022
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7. Incidence of cancer and related deaths in hemoglobinopathies: A follow‐up of 4631 patients between 1970 and 2021

Author

Origa, Raffaella, primary, Gianesin, Barbara, additional, Longo, Filomena, additional, Di Maggio, Rosario, additional, Cassinerio, Elena, additional, Gamberini, Maria Rita, additional, Pinto, Valeria Maria, additional, Quarta, Antonella, additional, Casale, Maddalena, additional, La Nasa, Giorgio, additional, Caocci, Giovanni, additional, Piroddi, Antonio, additional, Piolatto, Andrea, additional, Di Mauro, Alessandra, additional, Romano, Claudia, additional, Gigante, Antonia, additional, Barella, Susanna, additional, Maggio, Aurelio, additional, Graziadei, Giovanna, additional, Perrotta, Silverio, additional, and Forni, Gian Luca, additional

Published
2022
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8. Incidence of cancer and related deaths in hemoglobinopathies: A follow‐up of 4631 patients between 1970 and 2021.

Author

Origa, Raffaella, Gianesin, Barbara, Longo, Filomena, Di Maggio, Rosario, Cassinerio, Elena, Gamberini, Maria Rita, Pinto, Valeria Maria, Quarta, Antonella, Casale, Maddalena, La Nasa, Giorgio, Caocci, Giovanni, Piroddi, Antonio, Piolatto, Andrea, Di Mauro, Alessandra, Romano, Claudia, Gigante, Antonia, Barella, Susanna, Maggio, Aurelio, Graziadei, Giovanna, and Perrotta, Silverio

Subjects
SICKLE cell anemia, PROSTATE cancer, HEPATOCELLULAR carcinoma, HEPATITIS C, BLOOD transfusion reaction
Abstract

Background: The correlation between thalassemia and malignancies other than hepatocellular carcinoma (HCC) and the possible relationship between other hemoglobinopathies and tumor risk have been poorly evaluated. Methods: Eight Italian specialized centers evaluated the incidence of malignant neoplasms in hemoglobinopathies as well as their sites and features. The study cohort included 4631 patients followed between 1970 and 2021 (transfusion‐dependent β‐thalassemia, 55.6%; non–transfusion‐dependent thalassemia, 17.7%; sickle cell disease, 17.6%; hemoglobin H disease, 8.3%). Results: A total of 197 diagnoses of cancer were reported (incidence rate, 442 cases per 100,000 person‐years). The liver was the most frequent site of tumors in both sexes, with a higher incidence (190 cases per 100,000 person‐years) in comparison with the general population found in all types of hemoglobinopathies (except hemoglobin H disease). In recent years, tumors have become the second cause of death in patients with transfusion‐dependent thalassemia. A lower risk of breast and prostate cancer was observed in the whole group of patients with hemoglobinopathies. The first cancer diagnoses dated back to the 1980s, and the incidence rate sharply increased after the 2000s. However, although the incidence rate of cancers of all sites but the liver continued to show an increasing trend, the incidence of HCC showed stability. Conclusions: These findings provide novel insights into the relationship between cancer and hemoglobinopathies and suggest that the overall risk is not increased in these patients. HCC has been confirmed as the most frequent tumor, but advances in chelation and the drugs that have led to the eradication of hepatitis C may explain the recent steadiness in the number of diagnoses that is reported here. Except for hepatocellular carcinoma, cancers are not more frequent in patients with hemoglobinopathies in comparison with the general Italian population. The incidence of hepatocellular carcinoma over time showed an increasing trend until 2012; since then, there has been a steady number of new diagnoses despite the increasing age of patients with hemoglobinopathies. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection

Author

Longo, Filomena, primary, Gianesin, Barbara, additional, Voi, Vincenzo, additional, Motta, Irene, additional, Pinto, Valeria Maria, additional, Piolatto, Andrea, additional, Spasiano, Anna, additional, Ruffo, Giovan Battista, additional, Gamberini, Maria Rita, additional, Barella, Susanna, additional, Mariani, Raffaella, additional, Fidone, Carmelo, additional, Rosso, Rosamaria, additional, Casale, Maddalena, additional, Roberti, Domenico, additional, Dal Zotto, Chiara, additional, Vitucci, Angelantonio, additional, Bonetti, Federico, additional, Pitrolo, Lorella, additional, Quaresima, Micol, additional, Ribersani, Michela, additional, Quota, Alessandra, additional, Arcioni, Francesco, additional, Campisi, Saveria, additional, Massa, Antonella, additional, De Michele, Elisa, additional, Lisi, Roberto, additional, Miano, Maurizio, additional, Bagnato, Sabrina, additional, Gentile, Massimo, additional, Carrai, Valentina, additional, Putti, Maria Caterina, additional, Serra, Marilena, additional, Gaglioti, Carmen, additional, Migone De Amicis, Margerita, additional, Graziadei, Giovanna, additional, De Giovanni, Anna, additional, Ricchi, Paolo, additional, Balocco, Manuela, additional, Quintino, Sabrina, additional, Borsellino, Zelia, additional, Fortini, Monica, additional, Denotti, Anna Rita, additional, Tartaglione, Immacolata, additional, Beccaria, Andrea, additional, Marziali, Marco, additional, Maggio, Aurelio, additional, Perrotta, Silverio, additional, Piperno, Alberto, additional, Filosa, Aldo, additional, Cappellini, Maria Domenica, additional, De Franceschi, Lucia, additional, Piga, Antonio, additional, and Forni, Gian Luca, additional

Published
2021
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12. ERN-EuroBloodNet European Registry of Patients Affected by Red Blood Cell Disorders and COVID-19

Author

Velasco, Pablo, primary, Longo, Filomena, additional, Piolatto, Andrea, additional, Bardón-Cancho, Eduardo J., additional, Ponce-Salas, Beatriz, additional, Flevari, Pagona, additional, Voskaridou, Ersi, additional, Biemond, Bart J., additional, Nur, Erfan, additional, Delaporta, Polyxeni, additional, Besse-Hammer, Tatiana, additional, Ruiz-Llobet, Anna, additional, Raso, Simona, additional, Spasiano, Anna, additional, Guerzoni, Maria Elena, additional, Beneitez-Pastor, David, additional, Dedeken, Laurence, additional, Pepe, Alessia, additional, Rosso, Rosamaria, additional, Kunz, Joachim B., additional, de Montalembert, Mariane, additional, Campisi, Saveria, additional, Glenthøj, Andreas, additional, Gonzalez Urdiales, Paula, additional, Benghiat, Fleur Samantha, additional, Azerad, Marie-Agnès, additional, Saunders, Christopher J., additional, Ferreira Faria, Teresa, additional, Casini, Tommaso, additional, Bagnato, Sabrina, additional, Van de Velde, Ann, additional, Labarque, Veerle, additional, Bertoni, Elisa, additional, Van Damme, An, additional, Diamantidis, Michael D., additional, Russo, Roberta, additional, Stiakaki, Eftichia, additional, Quota, Alessandra, additional, Christou, Soteroula, additional, Teles, Maria Jose, additional, Lafiatis, Ioannis, additional, Kerkhoffs, Jean-Louis, additional, Argüello Marina, María, additional, Lorite, Mikael, additional, Rodriguez, Alexis, additional, Iolascon, Achille, additional, Taher, Ali T., additional, Colombatti, Raffaella, additional, Roy, Noemi, additional, and Mañú Pereira, Maria Del Mar, additional

Published
2021
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13. Hemoglobinopathies and Cancer: Preliminary Results of an Italian Multicenter Experience

Author

Origa, Raffaella, primary, Longo, Filomena, additional, Di Maggio, Rosario, additional, Cassinerio, Elena, additional, Pinto, Valeria Maria, additional, Quarta, Antonella, additional, Casale, Maddalena, additional, Gianesin, Barbara, additional, Barella, Susanna, additional, Piolatto, Andrea, additional, Maggio, Aurelio, additional, Graziadei, Giovanna, additional, Romano, Claudia, additional, Perrotta, Silverio, additional, and Forni, Gian Luca, additional

Published
2021
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15. Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection.

Author

Longo, Filomena, Gianesin, Barbara, Voi, Vincenzo, Motta, Irene, Pinto, Valeria Maria, Piolatto, Andrea, Spasiano, Anna, Ruffo, Giovan Battista, Gamberini, Maria Rita, Barella, Susanna, Mariani, Raffaella, Fidone, Carmelo, Rosso, Rosamaria, Casale, Maddalena, Roberti, Domenico, Dal Zotto, Chiara, Vitucci, Angelantonio, Bonetti, Federico, Pitrolo, Lorella, and Quaresima, Micol

Published
2022
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19. Reply to 'Hepatocellular carcinoma in thalassemia and other hemoglobinopathies'

Author

Raffaella Origa, Barbara Gianesin, Filomena Longo, Rosario Di Maggio, Elena Cassinerio, Maria Rita Gamberini, Valeria Maria Pinto, Maddalena Casale, Giorgio La Nasa, Giovanni Caocci, Antonio Piroddi, Andrea Piolatto, Alessandra Di Mauro, Claudia Romano, Antonia Gigante, Susanna Barella, Aurelio Maggio, Giovanna Graziadei, Silverio Perrotta, Gian Luca Forni, Origa, Raffaella, Gianesin, Barbara, Longo, Filomena, Di Maggio, Rosario, Cassinerio, Elena, Gamberini, Maria Rita, Pinto, Valeria Maria, Casale, Maddalena, La Nasa, Giorgio, Caocci, Giovanni, Piroddi, Antonio, Piolatto, Andrea, Di Mauro, Alessandra, Romano, Claudia, Gigante, Antonia, Barella, Susanna, Maggio, Aurelio, Graziadei, Giovanna, Perrotta, Silverio, and Forni, Gian Luca

Subjects
Cancer Research, Oncology
Published
2023

20. Italian patients with hemoglobinopathies exhibit a 5-fold increase in age-standardized lethality due to SARS-CoV-2 infection

Author

Sabrina Quintino, Filomena Longo, Maurizio Miano, Vincenzo Voi, Maria Caterina Putti, Margerita Migone De Amicis, Monica Fortini, Susanna Barella, Barbara Gianesin, Federico Bonetti, Andrea Beccaria, Manuela Balocco, Andrea Piolatto, Saveria Campisi, Rosamaria Rosso, Angelantonio Vitucci, Valentina Carrai, Alessandra Quota, Zelia Borsellino, Antonio Piga, Maddalena Casale, Anna Rita Denotti, Michela Ribersani, Maria Rita Gamberini, Domenico Roberti, Alberto Piperno, Roberto Lisi, Carmelo Fidone, Maria Domenica Cappellini, Sabrina Bagnato, Anna De Giovanni, Micol Quaresima, Valeria Maria, Lorella Pitrolo, Marco Marziali, Giovanna Graziadei, Carmen Gaglioti, Aldo Filosa, Chiara Dal Zotto, Lucia De Franceschi, Irene Motta, Immacolata Tartaglione, Francesco Arcioni, Aurelio Maggio, Marilena Serra, Giovan Battista Ruffo, Massimo Gentile, Elisa De Michele, Anna Spasiano, Paolo Ricchi, Antonella Massa, Silverio Perrotta, R. Mariani, Gian Luca Forni, Longo, Filomena, Gianesin, Barbara, Voi, Vincenzo, Motta, Irene, Pinto, Valeria Maria, Piolatto, Andrea, Spasiano, Anna, Ruffo, Giovan Battista, Gamberini, Maria Rita, Barella, Susanna, Mariani, Raffaella, Fidone, Carmelo, Rosso, Rosamaria, Casale, Maddalena, Roberti, Domenico, Dal Zotto, Chiara, Vitucci, Angelantonio, Bonetti, Federico, Pitrolo, Lorella, Quaresima, Micol, Ribersani, Michela, Quota, Alessandra, Arcioni, Francesco, Campisi, Saveria, Massa, Antonella, De Michele, Elisa, Lisi, Roberto, Miano, Maurizio, Bagnato, Sabrina, Gentile, Massimo, Carrai, Valentina, Putti, Maria Caterina, Serra, Marilena, Gaglioti, Carmen, Migone De Amicis, Margerita, Graziadei, Giovanna, De Giovanni, Anna, Ricchi, Paolo, Balocco, Manuela, Quintino, Sabrina, Borsellino, Zelia, Fortini, Monica, Denotti, Anna Rita, Tartaglione, Immacolata, Beccaria, Andrea, Marziali, Marco, Maggio, Aurelio, Perrotta, Silverio, Piperno, Alberto, Filosa, Aldo, Cappellini, Maria Domenica, De Franceschi, Lucia, Piga, Antonio, and Forni, Gian Luca

Subjects
Sars-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Sars-CoV-2, hemoglobinopathies, Medicine, hemoglobinopathies,SARS-CoV-2 infection, Lethality, Hematology, hemoglobinopathies, business, Virology
Published
2022

21. Proteomic analysis of extracellular vesicles from medullospheres reveals a role for iron in the cancer progression of medulloblastoma

Author

Brigitte Bisaro, Andrea Piolatto, Giovanna Cenacchi, Cristina Zanini, Giorgia Mandili, Alice Poli, Francesco Novelli, Valentina Papa, Marco Forni, Bisaro, Brigitte, Mandili, Giorgia, Poli, Alice, Piolatto, Andrea, Papa, Valentina, Novelli, Francesco, Cenacchi, Giovanna, Forni, Marco, and Zanini, Cristina

Subjects
Medulloblastoma, business.industry, Extracellular vesicle, Bioinformatics, medicine.disease, Proteomics, medulloblastoma, Molecular medicine, In vitro, Cell biology, Cell culture, Medicine, Secretion, extracellular vesicle, Stem cell, business, proteomics, electron microscopy, Research Article
Abstract

Background Medulloblastoma (MB) is the most common malignant childhood brain tumor with the propensity to disseminate at an early stage, and is associated with high morbidity. New treatment strategies are needed to improve cure rates and to reduce life-long cognitive and functional deficits associated with current therapies. Extracellular Vesicles (EVs) are important players in cell-to-cell communication in health and diseases. A clearer understanding of cell-to-cell communication in tumors can be achieved by studying EV secretion in medullospheres. This can reveal subtle modifications induced by the passage from adherent to non-adherent growth, as spheres may account for the adaptation of tumor cells to the mutated environment. Methods Formation of medullospheres from MB cell lines stabilized in adherent conditions was obtained through culture conditioning based on low attachment flasks and specialized medium. EVs collected by ultracentrifugation, in adherent conditions and as spheres, were subjected to electron microscopy, NanoSight measurements and proteomics. Results Interestingly, iron carrier proteins were only found in EVs shed by CSC-enriched tumor cell population of spheres. We used iron chelators when culturing MB cell lines as spheres. Iron chelators induced a decrease in number/size of spheres and in stem cell populations able to initiate in vitro spheres formation. Conclusions This work suggests a not yet identified role of iron metabolism in MB progression and invasion and opens the possibility to use chelators as adjuvants in anti-tumoral chemotherapy.

Published
2015

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