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1. 131 - PAUTAS Y EFECTIVIDAD DE LAS TERAPIAS CUÁDRUPLES CON BISMUTO EN EUROPA: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Calvet, Xavier, primary, Gené, Emili, additional, Olmedo, Llum, additional, Bordin, Dmitry, additional, García-Morales, Natalia, additional, Hernández, Luis, additional, Gridnyev, Oleksiy, additional, Kupinskas, Juozas, additional, Gasbarrini, Antonio, additional, Boltin, Doron, additional, Babayeva, Gulustan, additional, Pinto, Ricardo Marcos, additional, Tepes, Bojan, additional, Buzas, Gyorgy M, additional, Papp, Veronika, additional, Simsek, Halis, additional, Cano-Català, Anna, additional, Moreira, Leticia, additional, Puig, Ignasi, additional, Nyssen, Olga P., additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
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2. 135 - TENDENCIAS DE PRESCRIPCIÓN DE TRATAMIENTOS ERRADICADORES Y DE SU EFECTIVIDAD EN PACIENTES NAÏVE A LO LARGO DE 10 AÑOS (2013-2022) EN EUROPA: DATOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI (HP-EUREG)

Author

Nyssen, Olga P., primary, Jonaitis, Laimas, additional, Pérez-Aísa, Ángeles, additional, Vaira, Dino, additional, Fiorini, Giulia, additional, Saracino, Ilaria Maria, additional, Tepes, Bojan, additional, Bordin, Dmitry, additional, Huerga, Alma Keco-, additional, Castro-Fernández, Manuel, additional, Lucendo, Alfredo, additional, Vologzhanina, Liudmila, additional, Bujanda, Luis, additional, Jurecic, Natasa Brglez, additional, Denkovski, Maja, additional, Lanas, Angel, additional, Martínez-Dominguez, Samuel, additional, Alfaro, Enrique, additional, Leja, Marcis, additional, Bumane, Renate, additional, Mammadov, Emin, additional, Babayeva, Gulustan, additional, Mahmudov, Umud, additional, Caldas, María, additional, Rodrigo, Luis, additional, Lerang, Frode, additional, Fadieienko, Galyna, additional, Abdulkhakov, Rustam, additional, Malavés, Jose María Huguet, additional, Zaytsev, Oleg, additional, Ilchishina, Tatiana, additional, Fernández-Salazar, Luis, additional, Alcaide, Noelia, additional, Velayos, Benito, additional, Sarsenbaeva, Aiman Silkanovna, additional, Bakulin, Igor, additional, Gravina, Antonietta G., additional, Romano, Marco, additional, Perona, Mónica, additional, Alekseenko, Sergey, additional, Barrio, Jesús, additional, Areia, Miguel, additional, Nuñez, Óscar, additional, Bogomolov, Pavel, additional, Rodríguez, Blas José Gómez, additional, Cajal, Manuel Dominguez-, additional, Camarero, Judith Gomez, additional, Moreno, Manuel Jiménez, additional, Georgopoulos, Sotirios, additional, Notari, Pedro Almela, additional, Tonkic, Ante, additional, Pellicano, Rinaldo, additional, Simsek, Halis, additional, Kunovský, Lumír, additional, Gasbarrini, Antonio, additional, Bote, Jose Maria Botargues, additional, Buzas, Gyorgy M, additional, Fernández-Bermejo, Miguel, additional, Phull, Perminder, additional, Venerito, Marino, additional, Malfertheiner, Peter, additional, Rosania, Rosa, additional, Link, Alexander, additional, Iyo, Eduardo, additional, Kupinskas, Juozas, additional, Shvets, Oleg, additional, Pinto, Ricardo Marcos, additional, Rokkas, Theodore, additional, Simsek, Ilkay, additional, Smith, Sinead, additional, Boltin, Doron, additional, Lamarque, Dominique, additional, Dobru, Daniela, additional, Marlicz, Wojciech, additional, Milivojevic, Vladimir, additional, Boyanova, Lyudmila, additional, Lamy, Vincent, additional, Doulberis, Michael, additional, Bytzer, Peter, additional, Capelle, Lisette, additional, Gridnyev, Oleksiy, additional, Ristimaki, Ari, additional, Cano-Català, Anna, additional, Puig, Ignasi, additional, Mégraud, Francis, additional, O’Morain, Colm, additional, and Gisbert, Javier P., additional

Published
2023
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3. sj-pdf-1-ueg-10.1177_2050640620972615 - Supplemental material for European Registry on Helicobacter pylori Management: single-capsule bismuth quadruple therapy is effective in real-world clinical practice

Author

Nyssen, Olga P, Angeles Perez-Aisa, Castro-Fernandez, Manuel, Pellicano, Rinaldo, Huguet, Jose M., Rodrigo, Luis, Ortuño, Juan, Gomez-Rodriguez, Blas Jose, Pinto, Ricardo Marcos, Areia, Miguel, Perona, Monica, Nuñez, Oscar, Romano, Marco, Gravina, Antonietta Gerarda, Pozzati, Liliana, Fernandez-Bermejo, Miguel, Venerito, Marino, Malfertheiner, Peter, Fernanadez-Salazar, Luis, Gasbarrini, Antonio, Vaira, Dino, Puig, Ignasi, Megraud, Francis, O’Morain, Colm, and Gisbert, Javier P

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 110308 Geriatrics and Gerontology, 69999 Biological Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-ueg-10.1177_2050640620972615 for European Registry on Helicobacter pylori Management: single-capsule bismuth quadruple therapy is effective in real-world clinical practice by Olga P Nyssen, Angeles Perez-Aisa, Manuel Castro-Fernandez, Rinaldo Pellicano, Jose M. Huguet, Luis Rodrigo, Juan Ortuño, Blas Jose Gomez-Rodriguez, Ricardo Marcos Pinto, Miguel Areia, Monica Perona, Oscar Nuñez, Marco Romano, Antonietta Gerarda Gravina, Liliana Pozzati, Miguel Fernandez-Bermejo, Marino Venerito, Peter Malfertheiner, Luis Fernanadez-Salazar, Antonio Gasbarrini, Dino Vaira, Ignasi Puig, Francis Megraud, Colm O’Morain and Javier P Gisbert in United European Gastroenterology Journal

Published
2020
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4. sj-pdf-2-ueg-10.1177_2050640620972615 - Supplemental material for European Registry on Helicobacter pylori Management: single-capsule bismuth quadruple therapy is effective in real-world clinical practice

Author

Nyssen, Olga P, Angeles Perez-Aisa, Castro-Fernandez, Manuel, Pellicano, Rinaldo, Huguet, Jose M., Rodrigo, Luis, Ortuño, Juan, Gomez-Rodriguez, Blas Jose, Pinto, Ricardo Marcos, Areia, Miguel, Perona, Monica, Nuñez, Oscar, Romano, Marco, Gravina, Antonietta Gerarda, Pozzati, Liliana, Fernandez-Bermejo, Miguel, Venerito, Marino, Malfertheiner, Peter, Fernanadez-Salazar, Luis, Gasbarrini, Antonio, Vaira, Dino, Puig, Ignasi, Megraud, Francis, O’Morain, Colm, and Gisbert, Javier P

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 110308 Geriatrics and Gerontology, 69999 Biological Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-2-ueg-10.1177_2050640620972615 for European Registry on Helicobacter pylori Management: single-capsule bismuth quadruple therapy is effective in real-world clinical practice by Olga P Nyssen, Angeles Perez-Aisa, Manuel Castro-Fernandez, Rinaldo Pellicano, Jose M. Huguet, Luis Rodrigo, Juan Ortuño, Blas Jose Gomez-Rodriguez, Ricardo Marcos Pinto, Miguel Areia, Monica Perona, Oscar Nuñez, Marco Romano, Antonietta Gerarda Gravina, Liliana Pozzati, Miguel Fernandez-Bermejo, Marino Venerito, Peter Malfertheiner, Luis Fernanadez-Salazar, Antonio Gasbarrini, Dino Vaira, Ignasi Puig, Francis Megraud, Colm O’Morain and Javier P Gisbert in United European Gastroenterology Journal

Published
2020
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6. European Registry on Helicobacter pyloriManagement: single-capsule bismuth quadruple therapy is effective in real-world clinical practice

Author

Nyssen, Olga P, Perez-Aisa, Angeles, Castro-Fernandez, Manuel, Pellicano, Rinaldo, Huguet, Jose M., Rodrigo, Luis, Ortuño, Juan, Gomez-Rodriguez, Blas Jose, Pinto, Ricardo Marcos, Areia, Miguel, Perona, Monica, Nuñez, Oscar, Romano, Marco, Gerarda Gravina, Antonietta, Pozzati, Liliana, Fernandez-Bermejo, Miguel, Venerito, Marino, Malfertheiner, Peter, Fernanadez-Salazar, Luis, Gasbarrini, Antonio, Vaira, Dino, Puig, Ignasi, Megraud, Francis, O’Morain, Colm, and Gisbert, Javier P

Abstract

Background There has been resurgence in the use of bismuth quadruple therapy (proton pump inhibitor, bismuth, tetracycline and metronidazole) for treating Helicobacter pyloriinfection thanks to a three-in-one single-capsule formulation.Objective To evaluate the effectiveness and safety of the single-capsule bismuth quadruple therapy.Methods Data were collected in a multicentre, prospective registry of the clinical practice of gastroenterologists on the management of H. pyloriinfection, where patients were registered at the Asociación Española de Gastroenterología REDCap database on an electronic case report form until January 2020. Effectiveness by modified intention-to-treat and per-protocol as well as multivariable analysis were performed. Independent factors evaluated were: age, gender, indication, compliance, proton pump inhibitor dose and treatment line.Results Finally, 2100 patients were prescribed single-capsule bismuth quadruple therapy following the technical sheet (i.e. three capsules every 6 hours for 10 days). The majority of these patients were naive (64%), with an average age of 50 years, 64% women and 16% with peptic ulcer. An overall modified intention-to-treat effectiveness of 92% was achieved. Eradication was over 90% in first-line treatment (95% modified intention-to-treat, n= 1166), and this was maintained as a rescue therapy, both in second (89% modified intention-to-treat, n= 375) and subsequent lines of therapy (third to sixth line: 92% modified intention-to-treat, n= 236). Compliance was the factor most closely associated with treatment effectiveness. Adverse events were generally mild to moderate, and 3% of patients reported a severe adverse event, leading to discontinuation of treatment in 1.7% of cases.Conclusions Single-capsule bismuth quadruple therapy achieved H. pylorieradication in approximately 90% of patients in real-world clinical practice, both as a first-line and rescue treatment, with good compliance and a favourable safety profile.

Published
2024
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7. 131 - PAUTAS Y EFECTIVIDAD DE LAS TERAPIAS CUÁDRUPLES CON BISMUTO EN EUROPA: RESULTADOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI(HP-EUREG)

Author

Calvet, Xavier, Gené, Emili, Olmedo, Llum, Bordin, Dmitry, García-Morales, Natalia, Hernández, Luis, Gridnyev, Oleksiy, Kupinskas, Juozas, Gasbarrini, Antonio, Boltin, Doron, Babayeva, Gulustan, Pinto, Ricardo Marcos, Tepes, Bojan, Buzas, Gyorgy M, Papp, Veronika, Simsek, Halis, Cano-Català, Anna, Moreira, Leticia, Puig, Ignasi, Nyssen, Olga P., Mégraud, Francis, O’Morain, Colm, and Gisbert, Javier P.

Published
2023
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8. 135 - TENDENCIAS DE PRESCRIPCIÓN DE TRATAMIENTOS ERRADICADORES Y DE SU EFECTIVIDAD EN PACIENTES NAÏVEA LO LARGO DE 10 AÑOS (2013-2022) EN EUROPA: DATOS DEL REGISTRO EUROPEO SOBRE EL MANEJO DE LA INFECCIÓN POR HELICOBACTER PYLORI(HP-EUREG)

Author

Nyssen, Olga P., Jonaitis, Laimas, Pérez-Aísa, Ángeles, Vaira, Dino, Fiorini, Giulia, Saracino, Ilaria Maria, Tepes, Bojan, Bordin, Dmitry, Huerga, Alma Keco-, Castro-Fernández, Manuel, Lucendo, Alfredo, Vologzhanina, Liudmila, Bujanda, Luis, Jurecic, Natasa Brglez, Denkovski, Maja, Lanas, Angel, Martínez-Dominguez, Samuel, Alfaro, Enrique, Leja, Marcis, Bumane, Renate, Mammadov, Emin, Babayeva, Gulustan, Mahmudov, Umud, Caldas, María, Rodrigo, Luis, Lerang, Frode, Fadieienko, Galyna, Abdulkhakov, Rustam, Malavés, Jose María Huguet, Zaytsev, Oleg, Ilchishina, Tatiana, Fernández-Salazar, Luis, Alcaide, Noelia, Velayos, Benito, Sarsenbaeva, Aiman Silkanovna, Bakulin, Igor, Gravina, Antonietta G., Romano, Marco, Perona, Mónica, Alekseenko, Sergey, Barrio, Jesús, Areia, Miguel, Nuñez, Óscar, Bogomolov, Pavel, Rodríguez, Blas José Gómez, Cajal, Manuel Dominguez-, Camarero, Judith Gomez, Moreno, Manuel Jiménez, Georgopoulos, Sotirios, Notari, Pedro Almela, Tonkic, Ante, Pellicano, Rinaldo, Simsek, Halis, Kunovský, Lumír, Gasbarrini, Antonio, Bote, Jose Maria Botargues, Buzas, Gyorgy M, Fernández-Bermejo, Miguel, Phull, Perminder, Venerito, Marino, Malfertheiner, Peter, Rosania, Rosa, Link, Alexander, Iyo, Eduardo, Kupinskas, Juozas, Shvets, Oleg, Pinto, Ricardo Marcos, Rokkas, Theodore, Simsek, Ilkay, Smith, Sinead, Boltin, Doron, Lamarque, Dominique, Dobru, Daniela, Marlicz, Wojciech, Milivojevic, Vladimir, Boyanova, Lyudmila, Lamy, Vincent, Doulberis, Michael, Bytzer, Peter, Capelle, Lisette, Gridnyev, Oleksiy, Ristimaki, Ari, Cano-Català, Anna, Puig, Ignasi, Mégraud, Francis, O’Morain, Colm, and Gisbert, Javier P.

Published
2023
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9. Tracheobronchial Polyflex stents for the management of benign refractory hypopharyngeal strictures.

Author

Silva RA, Mesquita N, Nunes PP, Cardoso E, Pinto RM, and Dias LM

Subjects
Adult, Aged, Constriction, Pathologic complications, Constriction, Pathologic pathology, Deglutition Disorders etiology, Deglutition Disorders surgery, Humans, Laryngeal Neoplasms therapy, Male, Middle Aged, Treatment Outcome, Constriction, Pathologic surgery, Hypopharynx pathology, Hypopharynx surgery, Stents
Abstract

Aim: To describe a modified technique for placement of a tracheobronchial self-expanding plastic stent (SEPS) in patients with benign refractory hypopharyngeal strictures in order to improve dysphagia and allow stricture remodeling., Methods: A case series of four consecutive patients with complex hypopharyngeal strictures after combined therapy for laryngeal cancer, previously submitted to multiple sessions of dilation without lasting improvement, is presented. All patients underwent placement of a small diameter and unflared tracheobronchial SEPS. Main outcome measurements were improvement of dysphagia and avoiding of repeated dilation., Results: The modified introducer system allowed an easy and technically successful deployment of the tracheobronchial Polyflex stent through the stricture. All four patients developed complications related to stent placement. Two patients had stent migration (one proximal and one distal), two patients developed phanryngocutaneous fistulas and all patients with stents in situ for more than 8 wk had hyperplastic tissue growth at the upper end of the stent. Stricture recurrence was observed at 4 wk follow-up after stent removal in all patients., Conclusion: Although technically feasible, placement of a tracheobronchial SEPS is associated with a high risk of complications. Small diameter stents must be kept in place for longer than 3 mo to allow adequate time for stricture remodeling.

Published
2012
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