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This electronic document is a “live” template and already the quadriceps angle, which is a very critical factor in determining knee alignment, biomechanics, and injury susceptibility, has received a considerable amount of attention in the scientific literature. Nevertheless, due to the fact that different studies have produced contradictory results, a thorough knowledge of its influence on knee injuries continues to elude researchers. By utilizing the PRISMA methodology, the purpose of this systematic review is to shed light on the connection between the quadriceps angle and the occurrence of knee injuries, with a particular emphasis on the gender differences that exist in this regard. Eight English-language journal papers that met severe requirements were accepted for examination after being subjected to a thorough screening process from the PubMed database, which covered publications from the years 2010 to 2013. According to the findings of our investigation, there is a favorable connection between increased quadriceps angles and a variety of knee problems, such as patellofemoral pain syndrome and patella dislocation. It is important to note that ladies have a higher tendency to knee injuries than males do. This can be related to the fact that girls have naturally bigger quadriceps angles than males do. In addition, our findings provide credence to the arguments made in the past that the quadriceps angle is directly related to the quadriceps muscle power. The findings of this analysis highlight the vital significance of doing more systematic research into the quadriceps angle as a major factor of knee malalignment and injury risk.