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5 results on '"Pinheiro, Ana Cristina N."'

2. Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis

Author

Guerra, Mateus T., Fonseca, Emerson A., Melo, Flavia M., Andrade, Viviane A., Aguiar, Carla J., Andrade, Lídia M., Pinheiro, Ana Cristina N., Casteluber, Marisa C. F., Resende, Rodrigo R., Pinto, Mauro C. X., Fernandes, Simone O. A., Cardoso, Valbert N., Souza-Fagundes, Elaine M., Menezes, Gustavo B., de Paula, Ana M., Nathanson, Michael H., and de Fátima Leite, Maria

Published
2011
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3. Succinate modulates Ca2+ transient and cardiomyocyte viability through PKA-dependent pathway

Author

Aguiar, Carla J., primary, Andrade, Vanessa L., additional, Gomes, Enéas R.M., additional, Alves, Márcia N.M., additional, Ladeira, Marina S., additional, Pinheiro, Ana Cristina N., additional, Gomes, Dawidson A., additional, Almeida, Alvair P., additional, Goes, Alfredo M., additional, Resende, Rodrigo R., additional, Guatimosim, Silvia, additional, and Leite, M. Fatima, additional

Published
2010
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5. Succinate modulates Ca2+ transient and cardiomyocyte viability through PKA-dependent pathway.

Author

Aguiar, Carla J., Andrade, Vanessa L., Gomes, Enéas R.M., Alves, Márcia N.M., Ladeira, Marina S., Pinheiro, Ana Cristina N., Gomes, Dawidson A., Almeida, Alvair P., Goes, Alfredo M., Resende, Rodrigo R., Guatimosim, Silvia, and Leite, M. Fatima

Subjects
HEART cells, G proteins, SUCCINIC acid, LABORATORY rats, GENE expression, ENZYME inhibitors, INTRACELLULAR calcium, CELLULAR signal transduction
Abstract

Abstract: GPR91 is an orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for succinate, a citric acid cycle intermediate, in several tissues. In the heart, the role of succinate is unknown. We now report that rat ventricular cardiomyocytes express GPR91. We found that succinate, through GPR91, increases the amplitude and the rate of decline of global Ca2+ transient, by increasing the phosphorylation levels of ryanodine receptor and phospholamban, two well known Ca2+ handling proteins. The effects of succinate on Ca2+ transient were abolished by pre-treatment with adenylyl cyclase and cAMP-dependent protein kinase (PKA) inhibitors. Direct PKA activation by succinate was further confirmed using a FRET-based A-kinase activity reporter. Additionally, succinate decreases cardiomyocyte viability through a caspase-3 activation pathway, effect also prevented by PKA inhibition. Taken together, these observations show that succinate acts as a signaling molecule in cardiomyocytes, modulating global Ca2+ transient and cell viability through a PKA-dependent pathway. [Copyright &y& Elsevier]

Published
2010
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