10 results on '"Ping-Lun, Hsieh"'
Search Results
2. Comparative study on shear failure behavior of squat high-strength steel reinforced concrete shear walls with various high-strength concrete materials
- Author
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Chung Chan Hung and Ping Lun Hsieh
- Subjects
Yield (engineering) ,Materials science ,Squat ,Building and Construction ,Spall ,Shear (geology) ,Architecture ,Volume fraction ,Shear strength ,Shear wall ,Composite material ,Safety, Risk, Reliability and Quality ,Reinforcement ,Civil and Structural Engineering - Abstract
The shear failure behavior of four squat shear walls with high-strength steel (HSS) and high-strength concrete (HSC) was experimentally investigated in this study. The experimental variables are the steel grade, namely SD420 and SD785, and the type of HSC materials, namely commercially available HSC with the inclusion of steel fibers and ultra-high performance concrete (UHPC) with or without steel fibers. The squat walls were tested under displacement reversals and their cyclic responses were extensively compared using various performance measures. The results indicate that the addition of steel fibers in the squat walls transformed the shear critical damage pattern from significant concrete spalling to localized diagonal cracks. The HSS reinforced squat wall made using commercially available HSC with the addition of a 0.75% volume fraction of steel fibers had a load-displacement response, energy dissipation capacity, and shear strength comparable to those of the squat walls made using specially mixed UHPC containing a 1.5% volume fraction of steel fibers. Moreover, while the high-strength horizontal reinforcement in the squat non-fiber HSC did not yield until the end of the test, its yield strength was fully utilized when it was used in the fiber-reinforced HSC walls. In addition to the experimental study, the applicability of existing design codes and the softened strut-and-tie model for assessing the shear strength of the high-strength squat walls was evaluated. more...
- Published
- 2020
- Full Text
- View/download PDF
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3. Trajectories of functional exercise capacity in patients undergoing pulmonary rehabilitation
- Author
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Li-Ying Wang, Pei-Yu Yang, Hsiao-Chen Lin, Meng-Yueh Chien, Huey-Dong Wu, Ping-Lun Hsieh, Jung-Yien Chien, Chien-Tzu Lee, and Jia-Shin Lin
- Subjects
COPD ,medicine.medical_specialty ,Group based ,business.industry ,Functional exercise ,medicine.medical_treatment ,Respiratory disease ,General Medicine ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Internal medicine ,Cohort ,Medicine ,Pulmonary rehabilitation ,In patient ,030212 general & internal medicine ,business ,Generalized estimating equation - Abstract
Background: Pulmonary rehabilitation (PR) is now considered fundamental when managing patients with chronic respiratory disease. The individual variation in functional exercise capacity (FEC) response to PR within the cohort is unknown. The purpose of this study was to identify FEC patterns in response to PR in patients with chronic respiratory disease using the trajectory modeling method. Methods: The data of 67 patients with the chronic respiratory disease were retrospectively reviewed and analyzed in this study. All patients received once-weekly supervised training for 8 weeks. Six-minute walk distance (6MWD) was used to measure FEC. Muscle strength and 6MWD were assessed at baseline, Week 4, Week 8 and monthly for two months after PR completion. Group-based trajectory modeling (GBTM) was used to identify patterns in 6MWD in response to PR. The generalized estimating equation method was then used to detect the differences within and between the trajectories of identified groups across time. Results: Patients were grouped into low- (n=13), moderate- (n=34) and high- (n=20) FEC group based on GBTM analysis. All groups demonstrated significant improvements in 6MWD and leg muscle strength after 8-week PR. Compared to the high-FEC group, a greater proportion of the patients in the low-FEC group required oxygen supplementation during training and had worse baseline leg muscle strength. Conclusions: Patients showed distinct patterns of 6MWD changes in response to 8-week PR. Distinct characteristics for the low-FEC group included poor lower extremity strength and a greater proportion of required oxygen use at home and during training. more...
- Published
- 2019
- Full Text
- View/download PDF
4. Trajectories of functional exercise capacity in patients undergoing pulmonary rehabilitation
- Author
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Chien-Tzu, Lee, Ping-Lun, Hsieh, Meng-Yueh, Chien, Jung-Yien, Chien, Huey-Dong, Wu, Jia-Shin, Lin, Hsiao-Chen, Lin, Pei-Yu, Yang, and Li-Ying, Wang
- Subjects
Aged, 80 and over ,Lung Diseases ,Male ,Exercise Tolerance ,Time Factors ,Oxygen Inhalation Therapy ,Walk Test ,Recovery of Function ,Middle Aged ,chronic respiratory disease ,Exercise Therapy ,functional exercise capacity ,Treatment Outcome ,trajectory ,Chronic Disease ,Humans ,Female ,Muscle Strength ,Muscle, Skeletal ,Lung ,exercise training ,Aged ,Retrospective Studies ,Original Research - Abstract
Background: Pulmonary rehabilitation (PR) is now considered fundamental when managing patients with chronic respiratory disease. The individual variation in functional exercise capacity (FEC) response to PR within the cohort is unknown. The purpose of this study was to identify FEC patterns in response to PR in patients with chronic respiratory disease using the trajectory modeling method. Methods: The data of 67 patients with the chronic respiratory disease were retrospectively reviewed and analyzed in this study. All patients received once-weekly supervised training for 8 weeks. Six-minute walk distance (6MWD) was used to measure FEC. Muscle strength and 6MWD were assessed at baseline, Week 4, Week 8 and monthly for two months after PR completion. Group-based trajectory modeling (GBTM) was used to identify patterns in 6MWD in response to PR. The generalized estimating equation method was then used to detect the differences within and between the trajectories of identified groups across time. Results: Patients were grouped into low- (n=13), moderate- (n=34) and high- (n=20) FEC group based on GBTM analysis. All groups demonstrated significant improvements in 6MWD and leg muscle strength after 8-week PR. Compared to the high-FEC group, a greater proportion of the patients in the low-FEC group required oxygen supplementation during training and had worse baseline leg muscle strength. Conclusions: Patients showed distinct patterns of 6MWD changes in response to 8-week PR. Distinct characteristics for the low-FEC group included poor lower extremity strength and a greater proportion of required oxygen use at home and during training., Video abstract Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/t22YUjWq6rU more...
- Published
- 2019
5. Resistance Training Improves Muscle Function and Cardiometabolic Risks But Not Quality of Life in Older People With Type 2 Diabetes Mellitus: A Randomized Controlled Trial
- Author
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Chin-Hsiao Tseng, Ping-Lun Hsieh, Yufeng Jane Tseng, and Wei-Shiung Yang
- Subjects
Male ,medicine.medical_specialty ,Blood Pressure ,Timed Up and Go test ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,law ,Diabetes mellitus ,Medicine ,Humans ,030212 general & internal medicine ,Muscle Strength ,Muscle, Skeletal ,Aerobic capacity ,Glycemic ,Aged ,Exercise Tolerance ,business.industry ,Rehabilitation ,Type 2 Diabetes Mellitus ,Resistance Training ,030229 sport sciences ,medicine.disease ,Blood pressure ,Diabetes Mellitus, Type 2 ,Physical therapy ,Body Composition ,Quality of Life ,Female ,Geriatrics and Gerontology ,business - Abstract
Background and purpose In older people with type 2 diabetes mellitus (T2DM), the effects of aging and T2DM may compromise the function of skeletal muscle, deteriorate metabolic status, and jeopardize physical performance, aerobic capacity, and quality of life (QoL). The purpose of this study was to investigate the effects of 12 weeks of resistance training (RT) on muscle function, physical performance, cardiometabolic risks, and QoL in older people with T2DM. Methods This study was a randomized controlled trial that employed block randomization, assessor blinding, and the intention-to-treat principle. Thirty people 65 years or older with a diagnosis of T2DM were randomly assigned to either an exercise group or a control group and were further stratified by gender. The exercise group performed 8 RT exercises in 3 sets of 8 to 12 repetitions at 75% 1-repetition maximum (1-RM) 3 times per week for 12 weeks. The control group received usual care and maintained their daily activities and lifestyle. Muscle function (1-RM and muscle oxygenation responses), physical performance (5-repetition sit-to-stand test and Timed Up and Go test), cardiometabolic risks (aerobic capacity, blood pressure, body composition, glycemic control, lipids levels, and high-sensitivity C-reactive protein levels), and QoL (Audit of Diabetes-Dependent Quality of Life 19) were assessed at baseline (week 0) and after the 12-week interventions (week 12). Results The 1-RM chest-press and leg-press strength and physical performance in 5-repetition sit-to-stand test were significantly improved in the exercise group compared with the controls after the interventions. The exercise group had significantly lower resting systolic blood pressure (by -12.1 mm Hg, P = 0.036) than did the controls after 12 weeks of RT, without any significant within-group change in either group after intervention. The waist circumference, fasting glucose levels, and peak diastolic blood pressure tended to favor RT over usual care after the interventions. Conclusion Twelve weeks of RT increased the maximal strength in chest-press and leg-press tests, and improved 5-repetition sit-to-stand performance in older people with T2DM. Our study demonstrated that supervised, structured RT was able to promote muscle function and alleviate cardiometabolic risks in people with T2DM 65 years or older. more...
- Published
- 2016
6. Effects of Exercise Training on Autonomic Function in Chronic Heart Failure: Systematic Review
- Author
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Shu-Fang Hsiao, Chung-Yin Hsu, Meng-Yueh Chien, and Ping-Lun Hsieh
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Autonomic function ,medicine.medical_specialty ,lcsh:Medicine ,Review Article ,General Biochemistry, Genetics and Molecular Biology ,law.invention ,Randomized controlled trial ,law ,Heart Rate ,Heart rate ,medicine ,Heart rate variability ,Aerobic exercise ,Humans ,Exercise ,Balance (ability) ,Randomized Controlled Trials as Topic ,Heart Failure ,General Immunology and Microbiology ,business.industry ,lcsh:R ,General Medicine ,medicine.disease ,Exercise Therapy ,Heart failure ,Autonomic imbalance ,Chronic Disease ,Physical therapy ,business ,human activities ,circulatory and respiratory physiology - Abstract
Objectives. Cardiac autonomic imbalance accompanies the progression of chronic heart failure (CHF). It is unclear whether exercise training could modulate autonomic control in CHF. This study aimed to review systematically the effects of exercise training on heart rate recovery (HRR) and heart rate variability (HRV) in patients with CHF.Methods. Literatures were systematically searched in electronic databases and relevant references. Only published randomized controlled trials (RCTs) focusing on exercise training for CHF were eligible for inclusion. Outcome measurements included HRR and HRV parameters.Results. Eight RCTs were eligible for inclusion and provided data on 280 participants (186 men). The participants were 52–70 years of age with New York Heart Association functional class II-III of CHF. Each study examined either aerobic or resistance exercise. Two trials addressed outcome of HRR and six HRV among these studies. Two RCTs showed that moderate aerobic exercise could improve HRR at 2 minutes after exercise training in CHF. Five of six RCTs demonstrated positive effects of exercise training on HRV which revealed the increments in high frequency (HF) and decrements in LF (low frequency)/HF ratio after training.Conclusion. Participation in an exercise training program has positive effects on cardiac autonomic balance in patients with CHF. more...
- Published
- 2015
7. Genipin-cross-linked poly(L-lysine)-based hydrogels: synthesis, characterization, and drug encapsulation
- Author
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Steven S.-S. Wang, Yu Tien Chen, Jeng Shiung Jan, Pei Shan Chen, and Ping Lun Hsieh
- Subjects
Time Factors ,Compressive Strength ,Drug Compounding ,complex mixtures ,chemistry.chemical_compound ,Mice ,Colloid and Surface Chemistry ,Tissue engineering ,Polymer chemistry ,Spectroscopy, Fourier Transform Infrared ,Animals ,Iridoids ,Polylysine ,Physical and Theoretical Chemistry ,chemistry.chemical_classification ,Cationic polymerization ,Hydrogels ,Surfaces and Interfaces ,General Medicine ,Polymer ,3T3 Cells ,Fibroblasts ,Hydrogen-Ion Concentration ,Controlled release ,Bromelains ,Cross-Linking Reagents ,Freeze Drying ,Chemical engineering ,chemistry ,Doxorubicin ,Drug delivery ,Self-healing hydrogels ,Genipin ,Microscopy, Electron, Scanning ,Drug carrier ,Peptides ,Biotechnology - Abstract
Genipin-cross-linked hydrogels composed of biodegradable and pH-sensitive cationic poly(L-lysine) (PLL), poly(L-lysine)-block-poly(L-alanine) (PLL-b-PLAla), and poly(L-lysine)-block-polyglycine (PLL-b-PGly) polypeptides were synthesized, characterized, and used as carriers for drug delivery. These polypeptide hydrogels can respond to pH-stimulus and their gelling and mechanical properties, degradation rate, and drug release behavior can be tuned by varying polypeptide composition and cross-linking degree. Comparing with natural polymers, the synthetic polypeptides with well-defined chain length and composition can warrant the preparation of the hydrogels with tunable properties to meet the criteria for specific biomedical applications. These hydrogels composed of natural building blocks exhibited good cell compatibility and enzyme degradability and can support cell attachment/proliferation. The evaluation of these hydrogels for in vitro drug release revealed that the controlled release profile was a biphasic pattern with a mild burst release and a moderate release rate thereafter, suggesting the drug molecules were encapsulated inside the gel matrix. With the versatility of polymer chemistry and conjugation of functional moieties, it is expected these hydrogels can be useful for biomedical applications such as polymer therapeutics and tissue engineering. more...
- Published
- 2013
8. Resistance Training Improves Muscle Function and Cardiometabolic Risks But Not Quality of Life in Older People With Type 2 Diabetes Mellitus: A Randomized Controlled Trial.
- Author
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Ping-Lun Hsieh, Chin-Hsiao Tseng, Yufeng Jane Tseng, and Wei-Shiung Yang
- Subjects
ANALYSIS of variance ,CONFIDENCE intervals ,STATISTICAL correlation ,PEOPLE with diabetes ,HIGH performance liquid chromatography ,QUALITY of life ,STATISTICS ,DATA analysis ,RANDOMIZED controlled trials ,DATA analysis software ,DESCRIPTIVE statistics ,RESISTANCE training ,OLD age - Abstract
Background and Purpose: In older people with type 2 diabetes mellitus (T2DM), the effects of aging and T2DM may compromise the function of skeletal muscle, deteriorate metabolic status, and jeopardize physical performance, aerobic capacity, and quality of life (QoL). The purpose of this study was to investigate the effects of 12 weeks of resistance training (RT) on muscle function, physical performance, cardiometabolic risks, and QoL in older people with T2DM. Methods: This study was a randomized controlled trial that employed block randomization, assessor blinding, and the intention-to-treat principle. Thirty people 65 years or older with a diagnosis of T2DM were randomly assigned to either an exercise group or a control group and were further strati- fied by gender. The exercise group performed 8 RT exercises in 3 sets of 8 to 12 repetitions at 75% 1-repetition maximum (1-RM) 3 times per week for 12 weeks. The control group received usual care and maintained their daily activities and lifestyle. Muscle function (1-RM and muscle oxygenation responses), physical performance (5-repetition sit-to-stand test and Timed Up and Go test), cardiometabolic risks (aero- bic capacity, blood pressure, body composition, glycemic control, lipids levels, and high-sensitivity C-reactive protein levels), and QoL (Audit of Diabetes-Dependent Quality of Life 19) were assessed at baseline (week 0) and after the 12-week interventions (week 12). Results: The 1-RM chest-press and leg-press strength and physical performance in 5-repetition sit-to-stand test were significantly improved in the exercise group compared with the controls after the interventions. The exercise group had significantly lower resting systolic blood pressure (by - 12.1 mm Hg, P = 0.036) than did the controls after 12 weeks of RT, without any significant within-group change in either group after intervention. The waist circumference, fasting glucose levels, and peak diastolic blood pressure tended to favor RT over usual care after the interventions. Conclusion: Twelve weeks of RT increased the maximal strength in chest-press and leg-press tests, and improved 5-repetition sit-to-stand performance in older people with T2DM. Our study demonstrated that supervised, structured RT was able to promote muscle function and alleviate cardio- metabolic risks in people with T2DM 65 years or older. [ABSTRACT FROM AUTHOR] more...
- Published
- 2018
- Full Text
- View/download PDF
9. Silicification of genipin-cross-linked polypeptide hydrogels toward biohybrid materials and mesoporous oxides
- Author
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Pei Shan Chen, Jeng Shiung Jan, Bo Yu Chen, and Ping Lun Hsieh
- Subjects
Materials science ,law.invention ,Hydrophobic effect ,chemistry.chemical_compound ,Mice ,Microscopy, Electron, Transmission ,law ,Polymer chemistry ,Spectroscopy, Fourier Transform Infrared ,Animals ,General Materials Science ,Calcination ,Iridoids ,Nanocomposite ,Silicates ,Cross-link ,Hydrogels ,Oxides ,3T3 Cells ,Mesoporous silica ,chemistry ,Self-healing hydrogels ,Genipin ,Chromatography, Gel ,Microscopy, Electron, Scanning ,Mesoporous material ,Peptides - Abstract
A simple and versatile approach is proposed to use cross-linked polypeptide hydrogels as templates for silica mineralization, allowing the synthesis of polypeptide-silica hybrid hydrogels and mesoporous silica (meso-SiO(2)) by subsequent calcination. The experimental data revealed that the cross-linked polypeptide hydrogels comprised of interconnected, membranous network served as templates for the high-fidelity transcription of silica replicas spanning from nanoscale to microscale, resulting in hybrid network comprised of interpenetrated polypeptide nanodomains and silica. The mechanical properties of these as-prepared polypeptide-silica hybrid hydrogels were found to vary with polypeptide chain length and composition. The synergy between cross-link, hydrophobic interaction, and silica deposition can lead to the enhancement of their mechanical properties. The polypeptide-silica hybrid hydrogel with polypeptide and silica content as low as 1.1 wt% can achieve 114 kN/m(2) of compressive strength. By removing the polypeptide nanodomains, mesoporous silicas with average pore sizes ranged between 2 nm and 6 nm can be obtained, depending on polypeptide chain length and composition. The polypeptide-silica hybrid hydrogels demonstrated good cell compatibility and can support cell attachment/proliferation. With the versatility of polymer chemistry and feasibility of amine-catalyzed sol-gel chemistry, the present method is facile for the synthesis of green nanocomposites and biomaterials. more...
- Published
- 2012
10. Effects of exercise training in heart transplant recipients: a meta-analysis
- Author
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Ping-Lun Hsieh, Wan-Ju Chao, and Ying-Tai Wu
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Exercise intolerance ,law.invention ,Oxygen Consumption ,Randomized controlled trial ,Quality of life ,law ,Heart Rate ,medicine ,Humans ,Pharmacology (medical) ,Muscle Strength ,Leg press ,Muscle, Skeletal ,Wasting ,Randomized Controlled Trials as Topic ,Heart transplantation ,Heart Failure ,Exercise Tolerance ,Muscle Weakness ,business.industry ,Middle Aged ,Confidence interval ,Exercise Therapy ,Treatment Outcome ,Meta-analysis ,Chronic Disease ,Physical therapy ,Quality of Life ,Heart Transplantation ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objectives: Muscle wasting and exercise intolerance are common in heart transplant recipients. Most studies on the effects of exercise training have used relatively small sample sizes and are heterogeneous in nature. The purpose of this meta-analysis was to systematically review the relevant studies and investigate the effects of exercise training on exercise capacity and muscle strength in heart transplant recipients. Methods: A systematic search was adopted from electronic databases and relevant references, using medical subject heading key words related to heart transplantation and exercise. Only randomized controlled trials with exercise intervention versus usual care were included. The data were expressed as the weighted mean differences with 95% confidence intervals (CIs). Results: Altogether 6 studies were included. Peak oxygen consumption (VO2) was reported in 4 trials (117 patients), and muscle strength was reported in 3 trials (67 patients). Peak VO2 was significantly increased by 2.34 ml/kg/min (95% CI 0.63–4.05). One-repetition maxima of the chest press (23.28 kg, 95% CI 0.64–45.91) and leg press (28.84 kg, 95% CI 5.70–51.98) were significantly improved by exercise training. Conclusion: Exercise training is recommended for heart transplant recipients to improve peak VO2 and muscle strength despite the small number of trials included in this meta-analysis. more...
- Published
- 2011
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