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16. High plasma interleukin‐6 level, but not IL‐6 gene variants, as a predictive marker for the development of hepatocellular carcinoma in a Moroccan population.

Author

Tanouti, Ikram‐Allah, Fellah, Hassan, Haddaji, Asmaa, Zerrad, Chaimaa, Tahiri, Mohamed, Badre, Wafaa, Nfaoui, Khaoula, Pineau, Pascal, Benjelloun, Soumaya, and Ezzikouri, Sayeh

Subjects
MOROCCANS, GENETIC variation, HEPATOCELLULAR carcinoma, INTERLEUKIN-6, ENZYME-linked immunosorbent assay
Abstract

Chronic inflammation triggered by hepatitis B (HBV) and hepatitis C (HCV) viruses elevates interleukin 6 (IL‐6) levels, activating pathways that cause liver damage and contribute to hepatocellular carcinoma (HCC) development. In this study, we assessed IL‐6 levels and explored the correlation between the rs1800795 and rs1800797 variants of the IL‐6 gene and the risk of developing HCC. We conducted a case–control study involving 314 participants. Among them, 157 were HCC patients (94 anti‐HCV, 22 HBsAg and 41 metabolic dysfunction‐associated steatotic liver disease [MASLD]) and 157 controls. Genotyping for IL‐6 rs1800795 and rs1800797 polymorphisms was performed using real‐time polymerase chain reaction (PCR). Additionally, plasma IL‐6 levels were determined using enzyme‐linked immunosorbent assay. The IL‐6 levels were notably higher in patients compared to controls (p <.0001). Among HCC patients, those with MASLD exhibited higher plasma IL‐6 levels than those with HCV and HBV (p =.003). In male HCC patients, IL‐6 levels were significantly elevated compared to controls (p <.0001). Similarly, female patients showed significantly higher IL‐6 levels compared to female controls, though still lower than in male HCC patients (p =.023). However, no significant difference was observed in IL‐6 levels between male and female HCC patients (p =.129). Contrastingly, the genotype and allele distributions of the rs1800795 and rs1800797 polymorphisms in the IL‐6 gene displayed no association with HCC development (all p >.05). In Moroccan HCC patients, chronic liver inflammation is characterized by elevated levels of IL‐6, potentially playing a role in the progression of liver disease and tumourigenesis. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Association of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha Coding Variants with Hepatocellular Carcinoma Risk in the Moroccan Population: A Case-Control Study

Author

Tanouti, Ikram-Allah, primary, Fellah, Hassan, additional, El Fihry, Raouia, additional, Zerrad, Chaimaa, additional, Abounouh, Karima, additional, Tahiri, Mohamed, additional, Belkouchi, Abdelkader, additional, Badre, Wafaa, additional, Pineau, Pascal, additional, Benjelloun, Soumaya, additional, and Ezzikouri, Sayeh, additional

Published
2023
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29. Profile of hepatocellular carcinoma in the Republic of Moldova: first-hand information on the presentation, distribution and etiologies

Author

Turcanu Adela, Pitel Ecaterina, Dumbrava Vlada-Tatiana, Tcaciuc Eugen, Donscaia Ana, Peltec Angela, and Pineau Pascal

Subjects
hepatocellular carcinoma, hepatitis viruses, multiple infections, cirrhosis, liver cancer, moldova, Internal medicine, RC31-1245
Abstract

Introduction. Moldova is the European country with the highest incidence of hepatocellular carcinoma (HCC) in both sexes. There is, however, no data comprehensively describing the presentation and the risk factors of HCC in the country. We decided to analyze cases of HCC recently received in a tertiary healthcare Institution from Chisinau, the Moldovian capital.

Published
2019
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31. Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population.

Author

Zerrad, Chaimaa, Lkhider, Mustapha, Belkouchi, Abdelkader, Tanouti, Ikram-Allah, Badre, Wafaa, Tahiri, Mohamed, Ayassi, Sarra, Marchio, Agnès, Pineau, Pascal, Benjelloun, Soumaya, and Ezzikouri, Sayeh

Subjects
MOROCCANS, GENETIC variation, HEPATOCELLULAR carcinoma, TOLL-like receptors, SINGLE nucleotide polymorphisms, HAPLOTYPES
Abstract

Hepatocellular carcinoma (HCC) is the fifth most common human malignancy and the fourth most frequent cause of cancer-related deaths worldwide. Toll-like receptors (TLRs), are known to play a key role in hepatocarcinogenesis through induction of inflammation. We aimed to investigate the association between TLR2 rs3804099, TLR4 rs4986790, rs4986791, and rs11536889 and TLR5 rs5744174 and HCC risk in a total of 306 Moroccan subjects, including 152 HCC patient and 154 controls using a TaqMan allelic discrimination assay. Our result showed that the frequency of TLR4 rs11536889 C allele was higher in control group than in HCC patients (OR = 0.52, 95% CI = 0.30-0.88, p = 0.01). Moreover, under the dominant model, we observed that CG/CC genotypes were protective factors against HCC risk (OR = 0.51, 95% CI = 0.28-0.91, p = 0.02). However, no significant differences were found in the allele and genotype frequencies of TLR4 rs4986790 and rs4986791, between HCC patients and controls. Similarly, genotypic frequencies of TLR2 and TLR5 polymorphisms did not differ significantly between HCC patients and controls. However, TLR4 haplotype analysis revealed that ACC haplotype may be protective of HCC risk in patients with HCC (OR = 0.53, 95% CI = 0.31-0.92, p = 0.02). In conclusion, our result suggest that TLR4 rs11536889 polymorphism and ACC haplotype may decrease risk of hepatocellular carcinoma in Moroccan population [ABSTRACT FROM AUTHOR]

Published
2023
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35. Supplementary Table 3 from Tbx3 Is a Downstream Target of the Wnt/β-Catenin Pathway and a Critical Mediator of β-Catenin Survival Functions in Liver Cancer

Author

Renard, Claire-Angélique, primary, Labalette, Charlotte, primary, Armengol, Carolina, primary, Cougot, Delphine, primary, Wei, Yu, primary, Cairo, Stefano, primary, Pineau, Pascal, primary, Neuveut, Christine, primary, de Reyniès, Aurélien, primary, Dejean, Anne, primary, Perret, Christine, primary, and Buendia, Marie-Annick, primary

Published
2023
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36. Supplementary Figure Legends 1-4 from Tbx3 Is a Downstream Target of the Wnt/β-Catenin Pathway and a Critical Mediator of β-Catenin Survival Functions in Liver Cancer

Author

Renard, Claire-Angélique, primary, Labalette, Charlotte, primary, Armengol, Carolina, primary, Cougot, Delphine, primary, Wei, Yu, primary, Cairo, Stefano, primary, Pineau, Pascal, primary, Neuveut, Christine, primary, de Reyniès, Aurélien, primary, Dejean, Anne, primary, Perret, Christine, primary, and Buendia, Marie-Annick, primary

Published
2023
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37. Supplementary Figures 1-4 from Tbx3 Is a Downstream Target of the Wnt/β-Catenin Pathway and a Critical Mediator of β-Catenin Survival Functions in Liver Cancer

Author

Renard, Claire-Angélique, primary, Labalette, Charlotte, primary, Armengol, Carolina, primary, Cougot, Delphine, primary, Wei, Yu, primary, Cairo, Stefano, primary, Pineau, Pascal, primary, Neuveut, Christine, primary, de Reyniès, Aurélien, primary, Dejean, Anne, primary, Perret, Christine, primary, and Buendia, Marie-Annick, primary

Published
2023
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38. Supplementary Table 2 from Tbx3 Is a Downstream Target of the Wnt/β-Catenin Pathway and a Critical Mediator of β-Catenin Survival Functions in Liver Cancer

Author

Renard, Claire-Angélique, primary, Labalette, Charlotte, primary, Armengol, Carolina, primary, Cougot, Delphine, primary, Wei, Yu, primary, Cairo, Stefano, primary, Pineau, Pascal, primary, Neuveut, Christine, primary, de Reyniès, Aurélien, primary, Dejean, Anne, primary, Perret, Christine, primary, and Buendia, Marie-Annick, primary

Published
2023
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40. Towards Elimination of Chronic Viral Hepatitis in French Polynesia?

Author

Teiti, Iotefa, primary, Aubry, Maite, additional, Glaziou, Philippe, additional, Mendiboure, Vincent, additional, Teissier, Anita, additional, Paoaafaite, Tuterarii, additional, Simon, Aurélie, additional, Chung, Kiyojiken, additional, Dian, Lisa, additional, Olivier, Sophie, additional, Pineau, Pascal, additional, Fontanet, Arnaud, additional, Condat, Bertrand, additional, Madec, Yoann, additional, Lastère, Stéphane, additional, and Cao-Lormeau, Van-Mai, additional

Published
2023
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41. Risk Factors of Liver Cirrhosis in Chad: Large Proportion of Cases without Clear Etiology

Author

Moussa, Ali Mahamat, primary, Pineau, Pascal, additional, Habkreo, Mayanna, additional, Elefi, Moussa Hassan, additional, Saleh, Tahir Mahamat, additional, Dehainsala, Maire, additional, Hachim, Mahamat Ali, additional, N’Gare, Adama Ahmed, additional, Fouda, Adoum Abderrazak, additional, Nadlaou, Bessimbaye, additional, and Chatté, Adawaye, additional

Published
2023
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43. Epidemiological characteristics of acute hepatitis A, 2013–2016: a cross-sectional study in Morocco

Author

Karami, Adnane, Fihry, Raouia El, Haddaji, Asmaa, Jadid, Fatima-Zahra, Zaidane, Imane, Chihab, Hajar, Ouladlahsen, Ahd, Tahiri, Mohamed, Pineau, Pascal, Akarid, Khadija, Benjelloun, Soumaya, and Ezzikouri, Sayeh

Abstract

Hepatitis A virus (HAV) is the common cause of acute hepatitis worldwide. Indeed, hepatitis A is endemic in developing countries such in Morocco and most residents are exposed in childhood. The characterisation of circulating strains of HAV remains crucial to understand the virological evolution and geo-temporal characteristics, which are essential for controlling infections and outbreaks. The purpose of the current study was the detection and characterisation of HAV strains circulating in Morocco by performing serological test, RT-PCR, sequencing and phylogenetic analysis. In this cross-sectional study, 618 suspected acute hepatitis cases were examined by Architect HAV abIgM. Of the 162 positives, 64 underwent RNA extraction. None of the suspected cases was immune to HAV and none of them had received a blood transfusion. Samples found positive by RT-PCR using primers targeting the VP1/VP2A junction and the VP1/VP3 capsid region of HAV were subjected to sequencing and phylogenetic analyses. HAV Acute infection rate was 26.2% [95% CI, 22.8–29.9], while viraemia reached 45% (29/64) after amplification of the VP3/VP1 region. Phylogenetic analysis of the VP1/2A segment revealed the presence of sub-genotypes IA and IB. Eighty-seven percent of the strains belonged to the subgenotype IA, while twelve percent to IB subgenotype. This first molecular study of acute hepatitis A in Morocco provided information about genetic diversity of HAV, revealing the co-circulating of only two subgenotypes (IA and IB). Notably, subgenotype IA was found to be the predominant subgenotype in Morocco.

Published
2023
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44. The peroxisome proliferator-activated receptor γ coactivator-1 alpha rs8192678 (Gly482Ser) variant and hepatitis B virus clearance.

Author

Abounouh, Karima, Tanouti, Ikram-Allah, Ouladlahsen, Ahd, Tahiri, Mohamed, Badre, Wafaa, Dehbi, Hind, Sarih, M'hammed, Benjelloun, Soumaya, Pineau, Pascal, and Ezzikouri, Sayeh

Subjects
PGC-1 protein, HEPATITIS B virus, PEROXISOME proliferator-activated receptors, CHRONIC hepatitis B, HEPATITIS B
Abstract

Chronic hepatitis B virus (CHB) infection is still incurable a major public health problem. It is yet unclear how host genetic factors influence the development of HBV infection. The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) has been shown to regulate hepatitis B virus (HBV). Several reports found that PPARGC1A variants are involved in a number of distinct liver diseases. Here we investigate whether the PPARGC1A rs8192678 (Gly482Ser) variant is involved in the spontaneous clearance of acute HBV infection and if it participates in chronic disease progression in Moroccan patients. Our study included 292 chronic hepatitis B (CHB) patients and 181 individuals who spontaneously cleared-HBV infection. We genotyped the rs8192678 SNP using a TaqMan allelic discrimination assay and then explored its association with spontaneous HBV clearance and CHB progression. Our data showed that individuals carrying CT and TT genotypes were more likely to achieve spontaneous clearance (OR = 0.48, 95% CI (0.32–0.73), p = 0.00047; OR = 0.28, 95% CI (0.15–0.53), p = 0.00005, respectively). Subjects carrying the mutant allele T were more likely to achieve spontaneous clearance (OR = 0.51, 95% CI (0.38–0.67), P = 2.68E-06). However, when we investigated the impact of rs8192678 on the progression of liver diseases, we neither observe any influence (p > 0.05) nor found any significant association between ALT, AST, HBV viral loads, and the PPARGC1A rs8192678 genotypes in patients with CHB (p > 0.05). Our result suggests that PPARGC1A rs8192678 may modulate acute HBV infection, and could therefore represent a potential predictive marker in the Moroccan population. [ABSTRACT FROM AUTHOR]

Published
2023
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