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ApTOLL is an aptamer specifically designed to antagonize toll-like receptor 4 (TLR4), which is involved in the innate immunity that promotes inflammatory responses in several diseases, including multiple sclerosis (MS). MS is a chronic, immune, demyelinating and neurodegenerative disease of the central nervous system that represents the second most important cause of neurological disability in young adults. The drugs currently available to treat this disease are immunomodulators and, to date, there are no therapeutic remyelinating drugs available to manage MS. In this study, we show that TLR4 is located in post-mortem cortical lesions of MS patients and as a result, we evaluated the effect of its inhibition by ApTOLL in two different animal models of MS, that of experimental autoimmune encephalomyelitis (EAE) and the cuprizone model. ApTOLL administration ameliorated the clinical symptomatology of the affected mice, which was associated with better preservation and restoration of myelin and oligodendrocytes in the demyelinated lesions of these animals. This revealed not only an immunomodulatory but also a remyelinating effect of the treatment with ApTOLL which was corroborated on purified cultures of rodent and adult human oligodendrocyte precursor cells (OPCs). In summary, the molecular nature of ApTOLL and its mechanism of action strongly supports its further study and use in novel strategies to treat MS and eventually, other demyelinating diseases., This work was supported by grant IND2018/BMD-9751 (Programa de Doctorados Industriales, Comunidad de Madrid, Spain), SAF2016-77575-R (Spanish Ministerio de Economía, Industria y Competitividad-MINECO), and the contract for technological support ApTLR2019-PC-MS-001 (AptaTargets, S.L., Spain) to FdC. BF-G is currently hired by Aptatargets S.L., PG-M is hired under PEJ-2020-AI/BMD-18541 de la Comunidad de Madrid, Spain (associated with the youth guarantee fund to FdC), SN had a predoctoral contract from the UCLM and was hired under SAF2012-40023, SAF2016- 77575-R, RD12-0032/0012 and RD16-0015/0019 (Spanish Ministerio de Economía, Industria y Competitividad-MINECO) and IND2018/BMD-9751, YL has been contracted under ReTics and SAF (to FdC). We thank David Segarra and Mª Eugenia Zarabozo (AptaTargets S.L.) for their constant technological support, Laude Garmendia for her indispensable constant help at the animal facility (Instituto Cajal-CSIC), including the extra effort during Covid-19 pandemics, Profs María Ángeles Moro (Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid and Universidad Complutense de Madrid, Spain) and Ignacio Lizasoaín (Universidad Complutense de Madrid, Spain) for lending us the TLR4 knockout mice, and the former GNDe member Dr. Carolina MeleroJerez (currently working at JazzPharma, Spain) for the initial training of BF-G on EAE animal model and different techniques at the laboratory. Human samples were supplied by the UK Multiple Sclerosis Tissue Bank, funded by the Multiple Sclerosis Society of Great Britain and Northern Ireland (registered charity 207495).

We present a detailed simulation study of the signatures from the sequential decays of the triple-strange pbar p -> {\Omega}+{\Omega}- -> K+{\Lambda}barK- {\Lambda} -> K+pbar{\pi}+K-p{\pi}- process in the PANDA central tracking system with focus on hit patterns and precise time measurement. We present a systematic approach for studying physics channels at the detector level and develop input criteria for tracking algorithms and trigger lines. Finally, we study the beam momentum dependence on the reconstruction efficiency for the PANDA detector.

[Resumen] El presente TFG surge de la necesidad de complementar un ERP personalizado con la integración de los módulos de gestión comercial y administrativa. Una empresa, dedicada a la comercialización de piedra al por mayor, ya cuenta con un ERP propio, pero desea ampliar sus funcionalidades para poder tener un mayor control y trazabilidad de sus productos. Además, quiere mejorar la toma de decisiones con información detallada de sus ventas. El objetivo, es que un comercial de la empresa, pueda disponer; de la realización de pedidos desde cualquier lugar, así como de la información necesaria de los clientes y ventas, y todo ello en tiempo real. También, que el departamento de administración tenga una parte de consulta y definición de KPIs. Para esto se crea una aplicación web con todas estas funcionalidades. Estos sistemas facilitarán el trabajo a los usuarios de la aplicación web, pudiendo definir mejor las estrategias de venta y la toma de decisiones. [Abstract] This final project arises out of the need to complement a personalized ERP with the integration of commercial and administrative management modules. A stone wholesale company already has its own ERP, but wants to expand its functionalities in order to have greater control and traceability of its products. In addition, it wants to improve the decision-making with detailed information on its sales. The objective is that any commercial employee of the company, can have the orders that were made from anywhere, as well as the necessary information on customers and sales, and all this in real time. Also, that the administration department can take part in the consultation and definition of KPIs. For this, a web application is created with all these functionalities. These systems will facilitate the work of the web application users, being able to better define sales strategies and decision-making. Traballo fin de grao (UDC.FIC). Enxeñaría informática. Curso 2020/2021

[Resumen] El presente trabajo trata sobre la rehabilitación de la antigua fábrica conservera en el lugar de Ameixide, parroquia de Aldán, del ayuntamiento de Cangas, Pontevedra. Edificio histórico de finales del siglo XIX, fue construido para dar servicio a las necesidades de la época, por aquel entonces como fábrica de salazón. En la actualidad este edificio primitivo se encuentra en desuso en estado de ruinas. Con el fin de evitar la destrucción y olvido de edificios históricos del pueblo, se pretende llevar a cabo una rehabilitación con un cambio de uso y adaptación del espacio para su nueva actividad. Para ello se pretende crear un centro de Talasoterapia en un entorno natural y marítimo único, ya que cumple una serie de características para su idoneidad: - Posición geográfica adecuada, proximidad inmediata al mar, con el fin de complementar y utilizar el clima marino como elemento fundamental para las curas, mediante las condiciones adecuadas que preserven las características terapéuticas de este elemento natural. - Garantía de un gran número de clientes en el centro ya que se encuentra en las Rías Baixas en un pueblo de veintiséis mil habitantes y que en verano es el segundo ayuntamiento de Galicia con más turismo gracias a sus treinta y ocho playas. - La falta de centros en el municipio que ofrezcan el mismo servicio. El proyecto de rehabilitación conserva intacto, revalorizando, la volumetría exterior de la construcción existente, de manera que las obras a realizar se reducen al acondicionamiento de su interior, mientras que exteriormente solo se acometen labores de conservación, limpieza de muros pétreos, acondicionamiento y sustitución de cubiertas, carpinterías, respectando por completo formas y volumetría. [Abstract] This essay deals with the rehabilitation of the old canning factory located in Ameixide, Aldán, in the municipality of Cangas, Pontevedra. This historic building dates back to the 19th century. It was originally built to cover the necessities at that time, being used as a salting factory. Nowadays, this old building is no longer in use and in ruins. In order to avoid the demolition and oblivion of all the historic buildings in town, it is intended to carry out a rehabilitation providing a change in use and space adaptation for its future exploitation. To this end, it is aimed to build a Thalassotherapy Centre. It would be located in a unique natural and marine environment. There are several characteristics that determine its suitability: - Perfect geography location. Close proximity to the sea. Its main goal is to complement and use the marine climate as a key element in treatment processes, working with the proper requirements to maintain the therapeutic properties of this natural element. - Guarantee to get a great number of customers for the town centre. The town is placed in Las Rias Baixas, with a population of twenty-six thousand. During the summer, the town becomes the second most-visited place in Galicia, all thanks to its beaches. - Lack of similar centres within the municipality. The rehabilitation project keeps the former construction untouched, increasing the value of its external volumes. Thus, the works are reduced to interior refurbishment, stone walls cleaning, maintenance and roofs and woodwork replacement, while always respecting shapes and volumes. Traballo fin de grao (UDC.EUAT). Arquitectura técnica. Curso 2015/2016.

The composition of the cellular proteome is under the control of multiple processes, one of the most important being translation initiation. The majority of eukaryotic cellular mRNAs initiates translation by the cap-dependent or scanning mode of translation initiation, a mechanism that depends on the recognition of the m7G(5′)ppp(5′)N, known as the cap. However, mRNAs encoding proteins required for cell survival under stress bypass conditions inhibitory to cap-dependent translation; these mRNAs often harbor internal ribosome entry site (IRES) elements in their 5′UTRs that mediate internal initiation of translation. This mechanism is also exploited by mRNAs expressed from the genome of viruses infecting eukaryotic cells. In this paper we discuss recent advances in understanding alternative ways to initiate translation across eukaryotic organisms.