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2. O41 Sexual dysfunction in women with systemic lupus erythematosus: a multicentre cross-sectional study

Author

Torres, Rita Pinheiro, primary, Lourenço, Maria Helena, additional, Rodrigues-Manica, Santiago, additional, Fraga, Vanessa, additional, Abreu, Catarina, additional, Costa, Roberto, additional, Matos, Carolina, additional, Mendes, Beatriz, additional, Samões, Beatriz, additional, Silva, Inês, additional, Pimentel-Santos, Fernando M, additional, Costa, Manuela, additional, Branco, Jaime C, additional, and Sepriano, Alexandre, additional

Published
2024
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4. Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

Author

Cortes, Adrian, Pulit, Sara L, Leo, Paul J, Pointon, Jenny J, Robinson, Philip C, Weisman, Michael H, Ward, Michael, Gensler, Lianne S, Zhou, Xiaodong, Garchon, Henri-Jean, Chiocchia, Gilles, Nossent, Johannes, Lie, Benedicte A, Førre, Øystein, Tuomilehto, Jaakko, Laiho, Kari, Bradbury, Linda A, Elewaut, Dirk, Burgos-Vargas, Ruben, Stebbings, Simon, Appleton, Louise, Farrah, Claire, Lau, Jonathan, Haroon, Nigil, Mulero, Juan, Blanco, Francisco J, Gonzalez-Gay, Miguel A, Lopez-Larrea, C, Bowness, Paul, Gaffney, Karl, Gaston, Hill, Gladman, Dafna D, Rahman, Proton, Maksymowych, Walter P, Crusius, J Bart A, van der Horst-Bruinsma, Irene E, Valle-Oñate, Raphael, Romero-Sánchez, Consuelo, Hansen, Inger Myrnes, Pimentel-Santos, Fernando M, Inman, Robert D, Martin, Javier, Breban, Maxime, Wordsworth, Bryan Paul, Reveille, John D, Evans, David M, de Bakker, Paul IW, and Brown, Matthew A

Subjects
Humans, Spondylitis, Ankylosing, Genetic Predisposition to Disease, Aminopeptidases, HLA-B27 Antigen, Minor Histocompatibility Antigens, Case-Control Studies, Major Histocompatibility Complex, Epistasis, Genetic, Polymorphism, Single Nucleotide, HLA-B40 Antigen, Epistasis, Genetic, Polymorphism, Single Nucleotide, Spondylitis, Ankylosing
Abstract

Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype.

Published
2015

5. Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients

Author

Amaral-Silva, Daniela, Gonçalves, Rute, Torrão, Rita C., Torres, Rita, Falcão, Sandra, Gonçalves, Maria João, Araújo, Maria Paula, Martins, Maria José, Lopes, Carina, Neto, Agna, Marona, José, Costa, Tiago, Castelão, Walter, Silva, Ana Bento, Silva, Inês, Lourenço, Maria Helena, Mateus, Margarida, Gonçalves, Nuno Pina, Manica, Santiago, Costa, Manuela, Pimentel-Santos, Fernando M., Mourão, Ana Filipa, Branco, Jaime C., and Soares, Helena

Published
2021
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7. Molecular Profiling of Axial Spondyloarthritis Patients Reveals an Association between Innate and Adaptive Cell Populations and Therapeutic Response to Tumor Necrosis Factor Inhibitors.

Author

Sobral, Daniel, Fernandes, Ana Filipa, Bernardes, Miguel, Pinto, Patrícia, Santos, Helena, Lagoas-Gomes, João, Tavares-Costa, José, Silva, José A. P., Dias, João Madruga, Bernardo, Alexandra, Gaillard, Jean-Charles, Armengaud, Jean, Benes, Vladimir, Domingues, Lúcia, Maia, Sara, Branco, Jaime C., Coelho, Ana Varela, and Pimentel-Santos, Fernando M.

Subjects
TUMOR necrosis factors, SPONDYLOARTHROPATHIES, CELL populations, HAPTOGLOBINS, BLOOD proteins, GENE expression
Abstract

This study aims at identifying molecular biomarkers differentiating responders and non-responders to treatment with Tumor Necrosis Factor inhibitors (TNFi) among patients with axial spondyloarthritis (axSpA). Whole blood mRNA and plasma proteins were measured in a cohort of biologic-naïve axSpA patients (n = 35), pre and post (14 weeks) TNFi treatment with adalimumab. Differential expression analysis was used to identify the most enriched pathways and in predictive models to distinguish responses to TNFi. A treatment-associated signature suggests a reduction in inflammatory activity. We found transcripts and proteins robustly differentially expressed between baseline and week 14 in responders. C-reactive protein (CRP) and Haptoglobin (HP) proteins showed strong and early decrease in the plasma of axSpA patients, while a cluster of apolipoproteins (APOD, APOA2, APOA1) showed increased expression at week 14. Responders to TNFi treatment present higher levels of markers of innate immunity at baseline, and lower levels of adaptive immunity markers, particularly B-cells. A logistic regression model incorporating ASDAS-CRP, gender, and AFF3, the top differentially expressed gene at baseline, enabled an accurate prediction of response to adalimumab in our cohort (AUC = 0.97). In conclusion, innate and adaptive immune cell type composition at baseline may be a major contributor to response to adalimumab in axSpA patients. A model including clinical and gene expression variables should also be considered. [ABSTRACT FROM AUTHOR]

Published
2024
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8. ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update

Author

Ramiro, Sofia, Nikiphorou, Elena, Sepriano, Alexandre, Ortolan, Augusta, Webers, Casper, Baraliakos, Xenofon, Landewé, Robert B M, Van den Bosch, Filip E, Boteva, Boryana, Bremander, Ann, Carron, Philippe, Ciurea, Adrian, van Gaalen, Floris A, Géher, Pál, Gensler, Lianne, Hermann, Josef, de Hooge, Manouk, Husakova, Marketa, Kiltz, Uta, López-Medina, Clementina, Machado, Pedro M, Marzo-Ortega, Helena, Molto, Anna, Navarro-Compán, Victoria, Nissen, Michael J, Pimentel-Santos, Fernando M, Poddubnyy, Denis, Proft, Fabian, Rudwaleit, Martin, Telkman, Mark, Zhao, Sizheng Steven, Ziade, Nelly, van der Heijde, Désirée, Ramiro, Sofia, Nikiphorou, Elena, Sepriano, Alexandre, Ortolan, Augusta, Webers, Casper, Baraliakos, Xenofon, Landewé, Robert B M, Van den Bosch, Filip E, Boteva, Boryana, Bremander, Ann, Carron, Philippe, Ciurea, Adrian, van Gaalen, Floris A, Géher, Pál, Gensler, Lianne, Hermann, Josef, de Hooge, Manouk, Husakova, Marketa, Kiltz, Uta, López-Medina, Clementina, Machado, Pedro M, Marzo-Ortega, Helena, Molto, Anna, Navarro-Compán, Victoria, Nissen, Michael J, Pimentel-Santos, Fernando M, Poddubnyy, Denis, Proft, Fabian, Rudwaleit, Martin, Telkman, Mark, Zhao, Sizheng Steven, Ziade, Nelly, and van der Heijde, Désirée

Abstract

OBJECTIVES: To update the Assessment of SpondyloArthritis international Society (ASAS)-EULAR recommendations for the management of axial spondyloarthritis (axSpA).METHODS: Following the EULAR Standardised Operating Procedures, two systematic literature reviews were conducted on non-pharmacological and pharmacological treatment of axSpA. In a task force meeting, the evidence was presented, discussed, and overarching principles and recommendations were updated, followed by voting.RESULTS: Five overarching principles and 15 recommendations with a focus on personalised medicine were agreed: eight remained unchanged from the previous recommendations; three with minor edits on nomenclature; two with relevant updates (#9, 12); two newly formulated (#10, 11). The first five recommendations focus on treatment target and monitoring, non-pharmacological management and non-steroidal anti-inflammatory drugs (NSAIDs) as first-choice pharmacological treatment. Recommendations 6-8 deal with analgesics and discourage long-term glucocorticoids and conventional synthetic disease-modifying antirheumatic drugs (DMARDs) for pure axial involvement. Recommendation 9 describes the indication of biological DMARDs (bDMARDs, that is, tumour necrosis factor inhibitors (TNFi), interleukin-17 inhibitors (IL-17i)) and targeted synthetic DMARDs (tsDMARDs, ie, Janus kinase inhibitors) for patients who have Ankylosing Spondylitis Disease Activity Score ≥2.1 and failed ≥2 NSAIDs and also have either elevated C reactive protein, MRI inflammation of sacroiliac joints or radiographic sacroiliitis. Current practice is to start a TNFi or IL-17i. Recommendation 10 addresses extramusculoskeletal manifestations with TNF monoclonal antibodies preferred for recurrent uveitis or inflammatory bowel disease, and IL-17i for significant psoriasis. Treatment failure should prompt re-evaluation of the diagnosis and consideration of the presence of comorbidities (#11). If active axSpA is confirmed, swi

Published
2023

11. ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update

Author

Ramiro, Sofia, primary, Nikiphorou, Elena, additional, Sepriano, Alexandre, additional, Ortolan, Augusta, additional, Webers, Casper, additional, Baraliakos, Xenofon, additional, Landewé, Robert B M, additional, Van den Bosch, Filip E, additional, Boteva, Boryana, additional, Bremander, Ann, additional, Carron, Philippe, additional, Ciurea, Adrian, additional, van Gaalen, Floris A, additional, Géher, Pál, additional, Gensler, Lianne, additional, Hermann, Josef, additional, de Hooge, Manouk, additional, Husakova, Marketa, additional, Kiltz, Uta, additional, López-Medina, Clementina, additional, Machado, Pedro M, additional, Marzo-Ortega, Helena, additional, Molto, Anna, additional, Navarro-Compán, Victoria, additional, Nissen, Michael J, additional, Pimentel-Santos, Fernando M, additional, Poddubnyy, Denis, additional, Proft, Fabian, additional, Rudwaleit, Martin, additional, Telkman, Mark, additional, Zhao, Sizheng Steven, additional, Ziade, Nelly, additional, and van der Heijde, Désirée, additional

Published
2022
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12. MULTI-OMICS TEMPORAL PROFILING OF AXIAL SPONDYLOARTHRITIS PATIENTS REVEALS AN ASSOCIATION OF THERAPEUTIC RESPONSE TO ADALIMUMAB WITH DISEASE ACTIVITY AND INNATE / ADAPTIVE IMMUNITY

Author

Sobral, Daniel, primary, Fernandes, Ana F, additional, Sardoo, Atlas, additional, Bernardes, Miguel, additional, Pinto, Patrícia, additional, Santos, Helena, additional, Lagoas-Gomes, João, additional, Tavares-Costa, José, additional, AP Silva, José, additional, Dias, João M, additional, Bernardo, Alexandra, additional, Gaillard, Jean-Charles, additional, Armengaud, Jean, additional, Benes, Vladimir, additional, Domingues, Lúcia, additional, Gouveia, Nélia, additional, Maia, Sara, additional, Branco, Jaime C, additional, Coelho, Ana V, additional, and Pimentel-Santos, Fernando M, additional

Published
2022
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13. The MyoSpA Study Protocol

Author

Atlas Mashayekhi Sardoo, Agna Neto, Rita Pinheiro Torres, Santiago Rodrigues-Manica, Lúcia Domingues, Carolina Lage Crespo, João Lagoas-Gomes, Vasco Mascarenhas, Mendes, César S., Antonio Galzerano, Sérgio Fernandes de Almeida, Alexandre Sepriano, Sofia Ramiro, Masi, Alfonse T., Kalyani Nair, Julia Costa, Bruno Miguel Alexandre, Tatiana Vassilevskaia, Celso Cunha, Daniel Sobral, Jaime Branco, Patrícia Gomes-Alves, Pimentel-Santos, Fernando M., Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), Instituto de Higiene e Medicina Tropical (IHMT), Instituto de Tecnologia Química e Biológica António Xavier (ITQB), Global Health and Tropical Medicine (GHTM), TB, HIV and opportunistic diseases and pathogens (THOP), UCIBIO - Applied Molecular Biosciences Unit, DCV - Departamento de Ciências da Vida, and CEFAGE (Pólo FCT/NOVA) - Centro de Estudos e Formação Avançada em Gestão e Economia

Subjects
Adult, Medicine(all), Adolescent, Biochemistry, Genetics and Molecular Biology(all), Muscles, Middle Aged, Mice, Young Adult, Cross-Sectional Studies, SDG 3 - Good Health and Well-being, Spondylarthritis, Animals, Humans, Spondylitis, Ankylosing, Axial Spondyloarthritis
Abstract

declArAtions ETHICS APPROVAL AND CONSENT TO PARTICIPATE The current study was submitted and approved by the ethical committee of University of Lisbon and Centro Hospitalar de Lisboa Ocidental, Hospital de Egas Moniz, EPE (Reference Number: 20170700050). The study will be conducted in accordance with the International Conference on Harmonization Good Clinical Practice (GCP) and the Declaration of Helsinki. Furthermore, voluntary written informed participants’ consent will be obtained from all subjects before the start of the study procedures. FUNDING This study was supported by iNOVA4Health (consortia to create a multidisdiplinary/translational network at the NOVA University, Lisbon, Portugal) and Portuguese Society of Rheumatology grants. BACKGROUND: Axial Spondyloarthritis (axSpA) is a chronic, inflammatory rheumatic disease that affects the axial skeleton, causing pain, stiffness, and fatigue. Genetics and environmental factors such as microbiota and microtrauma are known causes of disease susceptibility and progression. Murine models of axSpA found a decisive role for biomechanical stress as an inducer of enthesitis and new bone formation. Here, we hypothesize that muscle properties in axSpA patients are compromised and influenced by genetic background. OBJECTIVES: To improve our current knowledge of axSpA physiopathology, we aim to characterize axial and peripheral muscle properties and identify genetic and protein biomarker that might explain such properties. METHODS: A cross-sectional study will be conducted on 48 participants aged 18-50 years old, involving patients with axSpA (according to ASAS classification criteria, symptoms duration < 10 years) and healthy controls matched by gender, age, and levels of physical activity. We will collect epidemiological and clinical data and perform a detailed, whole body and segmental, myofascial characterization (focusing on multifidus, brachioradialis and the gastrocnemius lateralis) concerning: a) Physical Properties (stiffness, tone and elasticity), assessed by MyotonPRO®; b) Strength, by a dynamometer; c) Mass, by bioimpedance; d) Performance through gait speed and 60-second sit-to-stand test; e) Histological and cellular/ molecular characterization through ultrasound-guided biopsies of multifidus muscle; f) Magnetic Resonance Imaging (MRI) characterization of paravertebral muscles. Furthermore, we will perform an integrated transcriptomics and proteomics analysis of peripheral blood samples. DISCUSSION: The innovative and multidisciplinary approaches of this project rely on the elucidation of myofascial physical properties in axSpA and also on the establishment of a biological signature that relates to specific muscle properties. This hitherto unstudied link between gene/protein signatures and muscle properties may enhance our understanding of axSpA physiopathology and reveal new and useful diagnostic and therapeutic targets. publishersversion published

Published
2021

14. Muscle dysfunction in axial spondylarthritis: the MyoSpA study

Author

Neto, Agna, primary, Pinheiro Torres, Rita, additional, Ramiro, Sofia, additional, Sardoo, Atlas, additional, Rodrigues-Manica, Santiago, additional, Lagoas-Gomes, João, additional, Domingues, Lúcia, additional, Lage Crespo, Carolina, additional, Teixeira, Diana, additional, Sepriano, Alexandre, additional, Masi, Alfonse T., additional, Nair, Kalyani, additional, Gomes-Alves, Patrícia, additional, Costa, Júlia, additional, Branco, Jaime C., additional, and Pimentel-Santos, Fernando M., additional

Published
2022
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15. A cluster analysis in the worldwide ASAS-PerSpA study

Author

López-Medina, Clementina, Chevret, Sylvie, Molto, Anna, Sieper, Joachim, Duruöz, Tuncay, Kiltz, Uta, Elzorkany, Bassel, Hajjaj-Hassouni, Najia, Burgos-Vargas, Ruben, Maldonado-Cocco, José, Ziade, Nelly, Gavali, Meghna, Navarro-Compan, Victoria, Luo, Shue Fen, Biglia, Alessandro, Tae-Jong, Kim, Kishimoto, Mitsumasa, Pimentel-Santos, Fernando M., Gu, Jieruo, Muntean, Laura, Van Gaalen, Floris A., Geher, Pál, Magrey, Marina, Ibáñez-Vodnizza, Sebastián E., Bautista-Molano, Wilson, Maksymowych, Walter, MacHado, Pedro M., Landewé, Robert, Van Der Heijde, Desirée, Dougados, Maxime, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
musculoskeletal diseases, ankylosing, arthritis, Rheumatology, Immunology, Immunology and Allergy, spondylitis, psoriatic
Abstract

Objective To identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist. Methods Cross-sectional study with 24 participating countries. Consecutive patients diagnosed by their rheumatologist as PsA, axial SpA or peripheral SpA were enrolled. Four different cluster analyses were conducted: one using information on the specific location from all the peripheral manifestations, and a cluster analysis for each peripheral manifestation, separately. Multiple correspondence analyses and k-means clustering methods were used. Distribution of peripheral manifestations and clinical characteristics were compared across the different clusters. Results The different cluster analyses performed in the 4465 patients clearly distinguished a predominantly axial phenotype (cluster 1) and a predominantly peripheral phenotype (cluster 2). In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement: a predominantly involvement of upper versus lower limbs joints, a predominantly axial enthesitis versus peripheral enthesitis, and predominantly finger versus toe involvement in dactylitis. A poor agreement between the clusters and the rheumatologist € s diagnosis as well as with the classification criteria was found. Conclusion These results suggest the presence of two main phenotypes (predominantly axial and predominantly peripheral) based on the presence and location of the peripheral manifestations. publishersversion published

Published
2021

16. ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients

Author

Robinson, Philip C, Costello, Mary-Ellen, Leo, Paul, Bradbury, Linda A, Hollis, Kelly, Cortes, Adrian, Lee, Seunghun, Joo, Kyung Bin, Shim, Seung-Cheol, Weisman, Michael, Ward, Michael, Zhou, Xiaodong, Garchon, Henri-Jean, Chiocchia, Gilles, Nossent, Johannes, Lie, Benedicte A, Førre, Øystein, Tuomilehto, Jaakko, Laiho, Kari, Jiang, Lei, Liu, Yu, Wu, Xin, Elewaut, Dirk, Burgos-Vargas, Ruben, Gensler, Lianne S, Stebbings, Simon, Haroon, Nigil, Mulero, Juan, Fernandez-Sueiro, Jose Luis, Gonzalez-Gay, Miguel A, Lopez-Larrea, Carlos, Bowness, Paul, Gafney, Karl, Gaston, John S Hill, Gladman, Dafna D, Rahman, Proton, Maksymowych, Walter P, Xu, Huji, van der Horst-Bruinsma, Irene E, Chou, Chung-Tei, Valle-Oñate, Raphael, Romero-Sánchez, María Consuelo, Hansen, Inger Myrnes, Pimentel-Santos, Fernando M, Inman, Robert D, Martin, Javier, Breban, Maxime, Evans, David, Reveille, John D, Kim, Tae-Hwan, Wordsworth, B Paul, and Brown, Matthew A

Published
2015
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17. Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA study

Author

López-Medina, Clementina, primary, Chevret, Sylvie, additional, Molto, Anna, additional, Sieper, Joachim, additional, Duruöz, Tuncay, additional, Kiltz, Uta, additional, Elzorkany, Bassel, additional, Hajjaj-Hassouni, Najia, additional, Burgos-Vargas, Ruben, additional, Maldonado-Cocco, José, additional, Ziade, Nelly, additional, Gavali, Meghna, additional, Navarro-Compan, Victoria, additional, Luo, Shue-Fen, additional, Biglia, Alessandro, additional, Tae-Jong, Kim, additional, Kishimoto, Mitsumasa, additional, Pimentel-Santos, Fernando M, additional, Gu, Jieruo, additional, Muntean, Laura, additional, van Gaalen, Floris A, additional, Geher, Pál, additional, Magrey, Marina, additional, Ibáñez-Vodnizza, Sebastián E, additional, Bautista-Molano, Wilson, additional, Maksymowych, Walter, additional, Machado, Pedro M, additional, Landewé, Robert, additional, van der Heijde, Desirée, additional, and Dougados, Maxime, additional

Published
2021
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18. Spectrum of ankylosing spondylitis in Portugal. Development of BASDAI, BASFI, BASMI and mSASSS reference centile charts

Author

Pimentel-Santos, Fernando M., Mourão, Ana Filipa, Ribeiro, Célia, Costa, José, Santos, Helena, Barcelos, Anabela, Pinto, Patricia, Godinho, Fátima, Cruz, Margarida, Vieira-Sousa, Elsa, Santos, Rui André, Rabiais, Sara, Félix, Jorge, Fonseca, João Eurico, Guedes-Pinto, Henrique, Brown, Matthew A, Branco, Jaime C., and CORPOREA Study Group

Published
2012
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19. DAS28, CDAI and SDAI cut-offs do not translate the same information: results from the Rheumatic Diseases Portuguese Register Reuma.pt

Author

Martins, Fernando M., da Silva, José António Pereira, Santos, Maria José, Vieira-Sousa, Elsa, Duarte, Cátia, Santos, Helena, Costa, José António, Pimentel-Santos, Fernando M., Cunha, Inês, Cunha Miranda, Luís, Nóvoa, Teresa, Cruz, Margarida, Bernardes, Miguel, Araujo, Domingos, Pereira Silva, José Alberto, Silva, José Canas, Branco, Jaime Cunha, Gomes, José António Melo, Faustino, Augusto, Fonseca, João Eurico, and Canhão, Helena

Published
2015
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20. The Effect of ACTN3 and VDR Polymorphisms on Skeletal Muscle Performance in Axial Spondyloarthropathies

Author

Pimenta, Isabel, primary, Mateus, Hugo, additional, Rodrigues-Manica, Santiago, additional, Pinheiro-Torres, Rita, additional, Neto, Agna, additional, Domingues, Lúcia, additional, Lage Crespo, Carolina, additional, Sardoo, Atlas, additional, Machado, Pedro, additional, Branco, Jaime C., additional, Silva, Susana N., additional, and Pimentel-Santos, Fernando M., additional

Published
2021
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21. Comparative effectiveness and predictors of response to tumour necrosis factor inhibitor therapies in rheumatoid arthritis

Author

Canhão, Helena, Rodrigues, Ana Maria, Mourão, Ana Filipa, Martins, Fernando, Santos, Maria José, Canas-Silva, José, Polido-Pereira, Joaquim, Pereira Silva, José Alberto, Costa, José António, Araújo, Domingos, Silva, Cândida, Santos, Helena, Duarte, Cátia, da Silva, José Antonio Pereira, Pimentel-Santos, Fernando M., Branco, Jaime Cunha, Karlson, Elizabeth W., Fonseca, João Eurico, and Solomon, Daniel H.

Published
2012
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23. Effectiveness of switching between TNF inhibitors in patients with axial spondyloarthritis: is the reason to switch relevant?

Author

Manica, Santiago Rodrigues, primary, Sepriano, Alexandre, additional, Pimentel-Santos, Fernando M, additional, Gouveia, Nélia, additional, Barcelos, Anabela, additional, Branco, Jaime, additional, Bernardes, Miguel, additional, Ferreira, Raquel Miriam, additional, Vieira-Sousa, Elsa, additional, Barreira, Sofia, additional, Vinagre, Filipe, additional, Roque, Raquel, additional, Santos, Helena, additional, Madeira, Nathalie, additional, Rovisco, João, additional, Daniel, Alexandra, additional, and Ramiro, Sofia, additional

Published
2020
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24. Effect of biologic disease-modifying anti-rheumatic drugs targeting remission in axial spondyloarthritis: systematic review and meta-analysis

Author

Cruz-Machado, Ana Rita, primary, Rodrigues-Manica, Santiago, additional, Silva, Joana Leite, additional, Alho, Irina, additional, Coelho, Constança, additional, Duarte, Joana, additional, Florêncio, Cláudia, additional, Pimentel-Santos, Fernando M, additional, Tavares-Costa, José, additional, and Vieira-Sousa, Elsa, additional

Published
2020
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25. New Insights into Immunological Involvement in Congenital Disorders of Glycosylation (CDG) from a People-Centric Approach

Author

Francisco, Rita, primary, Pascoal, Carlota, additional, Marques-da-Silva, Dorinda, additional, Brasil, Sandra, additional, Pimentel-Santos, Fernando M., additional, Altassan, Ruqaiah, additional, Jaeken, Jaak, additional, Grosso, Ana Rita, additional, dos Reis Ferreira, Vanessa, additional, and Videira, Paula A., additional

Published
2020
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27. GO-DACT: a phase 3b randomised, double-blind, placebo-controlled trial of GOlimumab plus methotrexate (MTX) versus placebo plus MTX in improving DACTylitis in MTX-naive patients with psoriatic arthritis

Author

Vieira-Sousa, Elsa, primary, Alves, Pedro, additional, Rodrigues, Ana M, additional, Teixeira, Filipa, additional, Tavares-Costa, Jose, additional, Bernardo, Alexandra, additional, Pimenta, Sofia, additional, Pimentel-Santos, Fernando M, additional, Gomes, João Lagoas, additional, Aguiar, Renata, additional, Pinto, Patrícia, additional, Videira, Taciana, additional, Catita, Cristina, additional, Santos, Helena, additional, Borges, Joana, additional, Sequeira, Graça, additional, Ribeiro, Célia, additional, Teixeira, Lídia, additional, Ávila- Ribeiro, Pedro, additional, Martins, Fernando M, additional, Canhão, Helena, additional, McInnes, Iain B., additional, Ribeiro, Ruy M, additional, and Fonseca, João Eurico, additional

Published
2020
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29. Muscle Evaluation in Axial Spondyloarthritis—The Evidence for Sarcopenia

Author

Valido, Ana, Crespo, Carolina Lage, Pimentel-Santos, Fernando M., NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
sarcopenia, Medicine(all), muscle mass, muscle strength, physical performance, spondyloarthritis
Abstract

Sarcopenia is a syndrome defined as a progressive and generalized skeletal muscle disorder associated with an increased likelihood of adverse outcomes such as falls, fractures, physical disability, and death. The actual definition of sarcopenia is based on a reduction in the values of three parameters: strength, muscle mass quantity or quality, and physical performance (the determinant of severity). Muscle wasting is a common feature in several chronic diseases, such as spondyloarthritis (SpA), and significantly increases patient morbidity and mortality. Although there has been huge progress in this field over recent years, the absence of a clear definition and clear diagnostic criteria of sarcopenia has resulted in inconsistent information regarding muscle-involvement in SpA. Thus, the aim of this review is to collect relevant evidence on muscular changes occurring during the disease process from the published literature, according to the recommended tools for sarcopenia evaluation proposed by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). In addition, data from histological, electromyography, and biochemical muscle analyses of SpA patients are also reviewed. Overall, a reduction in muscle strength with a systemic decrease in lean mass seems to be associated with a gait speed compromise. This information is usually fragmented, with no studies considering the three parameters together. This paper represents a call-to-action for the design of new studies in the future. publishersversion published

Published
2019

30. Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects

Author

Pimentel-Santos, Fernando M, Ligeiro, Dário, Matos, Mafalda, Mourão, Ana F, Costa, José, Santos, Helena, Barcelos, Anabela, Godinho, Fátima, Pinto, Patricia, Cruz, Margarida, Fonseca, João E, Guedes-Pinto, Henrique, Branco, Jaime C, Brown, Matthew A, and Thomas, Gethin P

Published
2011
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31. Prognostic factors for recovery and non-recovery in patients with non-specific neck pain

Author

Domingues, Lucia, Cruz, Eduardo B., Pimentel-Santos, Fernando M., Ramiro, Sofia, Donato, Helena, Manica, Santiago Rodrigues, Hayden, Jill Alison, Buchbinder, Rachelle, Branco, Jaime C., NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
Medicine(all), recovery, prognostic factors, non-recovery, non-specific neck pain
Abstract

Made available in DSpace on 2018-12-07T23:17:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-11-25 publishersversion published

Published
2018

33. Translation, cross-cultural adaptation and validation of the Osteoarthritis Quality of Life (OAQoL) questionnaire for use in Portugal

Author

Gomes, João Lagoas, primary, Águeda, Ana Filipa, additional, Heaney, Alice, additional, Duarte, Cátia, additional, Lopes, Carina, additional, Costa, Tiago, additional, Marona, José, additional, Rodrigues-Manica, Santiago, additional, Maia, Sara, additional, Costa, Manuela, additional, Branco, Jaime C., additional, McKenna, Stephen P., additional, Barcelos, Anabela, additional, and Pimentel-Santos, Fernando M., additional

Published
2018
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35. Tools for the Screening of Sarcopenia: A Head-to-Head Comparison by the NOVA SarcoAging Group

Author

Ferreira-Dos-Santos, Guilherme, primary, Domingues, Lúcia, additional, Sepriano, Alexandre, additional, Mourão, Ana Filipa, additional, Silveira Botelho, Maria Amália, additional, Pereira, Carla Sandra., additional, Espino, Carlos Lodeiro, additional, Crespo, Carolina L., additional, Quaresma, Cláudia, additional, Neto, David Dias, additional, Nunes, Isabel L., additional, Capelo-Martinez, José Luís, additional, Santos, José Paulo, additional, Lapão, Luís Velez, additional, Gomes, Maria Isabel, additional, Santos Fonseca, Miguel Dos, additional, Gouveia, Nélia, additional, Paula Macedo, M., additional, Coelho, Pedro Simões, additional, Videira, Paula, additional, Barros, Pedro Pita, additional, Vassilenko, Valentina, additional, Pimentel-Santos, Fernando M., additional, Branco, Pedro Soares, additional, and Branco, Jaime C., additional

Published
2018
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36. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis

Author

van der Heijde, Désirée, primary, Ramiro, Sofia, additional, Landewé, Robert, additional, Baraliakos, Xenofon, additional, Van den Bosch, Filip, additional, Sepriano, Alexandre, additional, Regel, Andrea, additional, Ciurea, Adrian, additional, Dagfinrud, Hanne, additional, Dougados, Maxime, additional, van Gaalen, Floris, additional, Géher, Pál, additional, van der Horst-Bruinsma, Irene, additional, Inman, Robert D, additional, Jongkees, Merryn, additional, Kiltz, Uta, additional, Kvien, Tore K, additional, Machado, Pedro M, additional, Marzo-Ortega, Helena, additional, Molto, Anna, additional, Navarro-Compàn, Victoria, additional, Ozgocmen, Salih, additional, Pimentel-Santos, Fernando M, additional, Reveille, John, additional, Rudwaleit, Martin, additional, Sieper, Jochen, additional, Sampaio-Barros, Percival, additional, Wiek, Dieter, additional, and Braun, Jürgen, additional

Published
2017
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39. Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Author

CMM Groep Kaaij, Infection & Immunity, JC onderzoeksprogramma Methodologie, Cancer, Cortes, Adrian, Pulit, Sara L, Leo, Paul J, Pointon, Jenny J, Robinson, Philip C, Weisman, Michael H, Ward, Michael, Gensler, Lianne S, Zhou, Xiaodong, Garchon, Henri-Jean, Chiocchia, Gilles, Nossent, Johannes, Lie, Benedicte A, Førre, Øystein, Tuomilehto, Jaakko, Laiho, Kari, Bradbury, Linda A, Elewaut, Dirk, Burgos-Vargas, Ruben, Stebbings, Simon, Appleton, Louise, Farrah, Claire, Lau, Jonathan, Haroon, Nigil, Mulero, Juan, Blanco, Francisco J, Gonzalez-Gay, Miguel A, Lopez-Larrea, C, Bowness, Paul, Gaffney, Karl, Gaston, Hill, Gladman, Dafna D, Rahman, Proton, Maksymowych, Walter P, Crusius, J Bart A, van der Horst-Bruinsma, Irene E, Valle-Oñate, Raphael, Romero-Sánchez, Consuelo, Hansen, Inger Myrnes, Pimentel-Santos, Fernando M, Inman, Robert D, Martin, Javier, Breban, Maxime, Wordsworth, Bryan Paul, Reveille, John D, Evans, David M, de Bakker, Paul I W, Brown, Matthew A, CMM Groep Kaaij, Infection & Immunity, JC onderzoeksprogramma Methodologie, Cancer, Cortes, Adrian, Pulit, Sara L, Leo, Paul J, Pointon, Jenny J, Robinson, Philip C, Weisman, Michael H, Ward, Michael, Gensler, Lianne S, Zhou, Xiaodong, Garchon, Henri-Jean, Chiocchia, Gilles, Nossent, Johannes, Lie, Benedicte A, Førre, Øystein, Tuomilehto, Jaakko, Laiho, Kari, Bradbury, Linda A, Elewaut, Dirk, Burgos-Vargas, Ruben, Stebbings, Simon, Appleton, Louise, Farrah, Claire, Lau, Jonathan, Haroon, Nigil, Mulero, Juan, Blanco, Francisco J, Gonzalez-Gay, Miguel A, Lopez-Larrea, C, Bowness, Paul, Gaffney, Karl, Gaston, Hill, Gladman, Dafna D, Rahman, Proton, Maksymowych, Walter P, Crusius, J Bart A, van der Horst-Bruinsma, Irene E, Valle-Oñate, Raphael, Romero-Sánchez, Consuelo, Hansen, Inger Myrnes, Pimentel-Santos, Fernando M, Inman, Robert D, Martin, Javier, Breban, Maxime, Wordsworth, Bryan Paul, Reveille, John D, Evans, David M, de Bakker, Paul I W, and Brown, Matthew A

Published
2015

40. ERAP2is associated with ankylosing spondylitis inHLA-B27-positive andHLA-B27-negative patients

Author

Robinson, Philip C, primary, Costello, Mary-Ellen, additional, Leo, Paul, additional, Bradbury, Linda A, additional, Hollis, Kelly, additional, Cortes, Adrian, additional, Lee, Seunghun, additional, Joo, Kyung Bin, additional, Shim, Seung-Cheol, additional, Weisman, Michael, additional, Ward, Michael, additional, Zhou, Xiaodong, additional, Garchon, Henri-Jean, additional, Chiocchia, Gilles, additional, Nossent, Johannes, additional, Lie, Benedicte A, additional, Førre, Øystein, additional, Tuomilehto, Jaakko, additional, Laiho, Kari, additional, Jiang, Lei, additional, Liu, Yu, additional, Wu, Xin, additional, Elewaut, Dirk, additional, Burgos-Vargas, Ruben, additional, Gensler, Lianne S, additional, Stebbings, Simon, additional, Haroon, Nigil, additional, Mulero, Juan, additional, Fernandez-Sueiro, Jose Luis, additional, Gonzalez-Gay, Miguel A, additional, Lopez-Larrea, Carlos, additional, Bowness, Paul, additional, Gafney, Karl, additional, Gaston, John S Hill, additional, Gladman, Dafna D, additional, Rahman, Proton, additional, Maksymowych, Walter P, additional, Xu, Huji, additional, van der Horst-Bruinsma, Irene E, additional, Chou, Chung-Tei, additional, Valle-Oñate, Raphael, additional, Romero-Sánchez, María Consuelo, additional, Hansen, Inger Myrnes, additional, Pimentel-Santos, Fernando M, additional, Inman, Robert D, additional, Martin, Javier, additional, Breban, Maxime, additional, Evans, David, additional, Reveille, John D, additional, Kim, Tae-Hwan, additional, Wordsworth, B Paul, additional, and Brown, Matthew A, additional

Published
2015
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41. Comparative Effectiveness of Tocilizumab and TNF Inhibitors in Rheumatoid Arthritis Patients: Data from the Rheumatic Diseases Portuguese Register, Reuma.pt

Author

C. Romão, Vasco, primary, Santos, Maria José, additional, Polido-Pereira, Joaquim, additional, Duarte, Cátia, additional, Nero, Patrícia, additional, Miguel, Cláudia, additional, Costa, José António, additional, Bernardes, Miguel, additional, Pimentel-Santos, Fernando M., additional, Barcelos, Filipe, additional, Costa, Lúcia, additional, Melo Gomes, José António, additional, Pereira da Silva, José Alberto, additional, Branco, Jaime Cunha, additional, Canas da Silva, José, additional, Pereira da Silva, José António, additional, Fonseca, João Eurico, additional, and Canhão, Helena, additional

Published
2015
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42. DAS28, CDAI and SDAI cut-offs do not translate the same information: results from the Rheumatic Diseases Portuguese Register Reuma.pt

Author

Martins, Fernando M., primary, da Silva, José António Pereira, additional, Santos, Maria José, additional, Vieira-Sousa, Elsa, additional, Duarte, Cátia, additional, Santos, Helena, additional, Costa, José António, additional, Pimentel-Santos, Fernando M., additional, Cunha, Inês, additional, Cunha Miranda, Luís, additional, Nóvoa, Teresa, additional, Cruz, Margarida, additional, Bernardes, Miguel, additional, Araujo, Domingos, additional, Pereira Silva, José Alberto, additional, Silva, José Canas, additional, Branco, Jaime Cunha, additional, Gomes, José António Melo, additional, Faustino, Augusto, additional, Fonseca, João Eurico, additional, and Canhão, Helena, additional

Published
2014
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43. Differential Features Between Primary Ankylosing Spondylitis and Spondylitis Associated with Psoriasis and Inflammatory Bowel Disease

Author

PÉREZ ALAMINO, RODOLFO, primary, MALDONADO COCCO, JOSÉ A., additional, CITERA, GUSTAVO, additional, ARTURI, PABLO, additional, VAZQUEZ-MELLADO, JANITZIA, additional, SAMPAIO-BARROS, PERCIVAL D., additional, FLORES, DIANA, additional, BURGOS-VARGAS, RUBÉN, additional, SANTOS, HELENA, additional, CHAVEZ-CORRALES, JOSÉ E., additional, PALLEIRO, DANIEL, additional, GUTIERREZ, MIGUEL A., additional, VIEIRA-SOUSA, ELSA, additional, PIMENTEL-SANTOS, FERNANDO M., additional, PAIRA, SERGIO, additional, BERMAN, ALBERTO, additional, MORENO-ALVAREZ, MARIO, additional, and COLLANTES-ESTEVEZ, EDUARDO, additional

Published
2011
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44. The Portuguese Society of Rheumatology position paper on the use of biosimilars.

Author

Fonseca, João Eurico, Gonçalves, João, Araújo, Filipe, Cordeiro, Inês, Teixeira, Filipa, Canhão, Helena, Pereira da Silva, José António, Garcês, Sandra, Cunha Miranda, Luís, Ramiro, Sofia, Roxo, Ana, Pimentel-Santos, Fernando M., Tavares, Viviana, Neto, Adriano, Sepriano, Alexandre, Malcata, Armando, Faustino, Augusto, Silva, Cândida, Ambrósio, Catarina, and Duarte, Cátia

Abstract

Biotechnological drugs have become a fundamental resource for the treatment of rheumatic patients. Patent expiry of some of these drugs created the opportunity for biopharmaceutical manufacturers to develop biosimilar drugs intended to be as efficacious as the originator product but with a lower cost to healthcare systems. Due to the complex manufacturing process and highly intricate structure of biologicals, a biosimilar can never be an exact copy of its reference product. Consequently, regulatory authorities issued strict preclinical and clinical guidelines to ensure safety and effica cy equivalence and, in September 2013, the biosimilar of infliximab was the first biosimilar monoclonal antibody to be authorized for use in the European Union. The current document is a position statement of the "Sociedade Portuguesa de Reumatologia" (Portuguese Society of Rheumatology) on the use of biosimilar drugs in rheumatic diseases. Two systema tic literature reviews were performed, one concerning clinical trials and the other one concerning international position papers on biosimilars. The results were presented and discussed in a national meeting and a final position document was discussed, written and approved by Portuguese rheumatologists. Briefly, this position statement is contrary to automatic substitution of the originator by the biosimilar, defends either a different INN or the prescription by brand name, supports that switching between biosimilars and the originator molecule should be done after at least 6 months of treatment and based on the attending physician decision and after adequate patient information, recommends the registration of all biosimilar treated patients in Reuma.pt for efficacy, safety and immunogenicity surveillance, following the strategy already ongoing for originators, and opposes to extrapolation of indications approved to the originator to completely different diseases and/or age groups without adequate pre-clinical, safety or efficacy data. [ABSTRACT FROM AUTHOR]

Published
2014

45. Differential Features Between Primary Ankylosing Spondylitis and Spondylitis Associated with Psoriasis and Inflammatory Bowel Disease.

Author

Alamino, Rodolfo Pérez, Cocco, José A. Maldonado, Citera, Gustavo, Arturi, Pablo, Vazquez-Mellado, Janitzia, Sampaio-Barros, Percival D., Flores, Diana, Burgos-Vargas, Rubén, Santos, Helena, Chavez-Corrales, José E., Palleiro, Daniel, Gutierrez, Miguel A., Vieira-Sousa, Elsa, Pimentel-Santos, Fernando M., Paira, Sergio, Berman, Alberto, Moreno-Alvarez, Mario, and Collantes-Estevez, Eduardo

Published
2011
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46. Acta Reumatológica Portuguesa: perspectives in 2017.

Author

Vieira-Sousa, Elsa, Cavaleiro, João, Mourão, Ana Filipa, Rodrigues, Ana M., Albino-Teixeira, António, Pimentel-Santos, Fernando M., Oliveira-Ramos, Filipa, Canhão, Helena, Polido Pereira, Joaquim, Eurico Fonseca, João, da Silva, José António Pereira, Carlos Romeu, José, Melo Gomes, José, Costa, Lúcia, Graça, Luís, José Leandro, Maria, José Santos, Maria, Machado, Pedro M., and Ramiro, Sofia

Published
2018

47. Acta Reumatológica Portuguesa: perspectives in 2017.

Author

Vieira-Sousa, Elsa, Cavaleiro, João, Mourão, Ana Filipa, Rodrigues, Ana M., Albino-Teixeira, António, Pimentel-Santos, Fernando M., Oliveira-Ramos, Filipa, Canhão, Helena, Polido Pereira, Joaquim, Eurico Fonseca, João, Pereira da Silva, José António, Carlos Romeu, José, Melo Gomes, José, Costa, Lúcia, Graça, Luís, José Leandro, Maria, José Santos, Maria, Machado, Pedro M., and Ramiro, Sofia

Published
2017

48. Additional file of Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects

Author

Pimentel-Santos, Fernando M, Ligeiro, Dário, Matos, Mafalda, Mourão, Ana F, Costa, José, Santos, Helena, Barcelos, Anabela, Godinho, Fátima, Pinto, Patricia, Cruz, Margarida, Fonseca, João E, Guedes-Pinto, Henrique, Branco, Jaime C, Brown, Matthew A, and Thomas, Gethin P

Subjects
3. Good health
Abstract

Additional file of Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects

49. Additional file 1 of Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects

Author

Pimentel-Santos, Fernando M, Ligeiro, Dário, Matos, Mafalda, Mourão, Ana F, Costa, José, Santos, Helena, Barcelos, Anabela, Godinho, Fátima, Pinto, Patricia, Cruz, Margarida, Fonseca, João E, Guedes-Pinto, Henrique, Branco, Jaime C, Brown, Matthew A, and Thomas, Gethin P

Subjects
3. Good health
Abstract

Additional file 1: Supplementary Table S1: Characteristics of subjects involved in microarrays study. BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index; BASMI, Bath Ankylosing Spondylitis Metrology Index; mSASSS, modified Stoke Ankylosing Spondylitis Spinal Score. (PDF 7 KB)

50. Additional file 4 of Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects

Author

Pimentel-Santos, Fernando M, Ligeiro, Dário, Matos, Mafalda, Mourão, Ana F, Costa, José, Santos, Helena, Barcelos, Anabela, Godinho, Fátima, Pinto, Patricia, Cruz, Margarida, Fonseca, João E, Guedes-Pinto, Henrique, Branco, Jaime C, Brown, Matthew A, and Thomas, Gethin P

Subjects
Data_FILES, 3. Good health
Abstract

Authors’ original file for figure 1

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