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7. Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

Author

van Akkeren, Jesse P., Algera, Anna Geke, Algoe, Cheetel K., van Amstel, Rombout B., Baur, Onno L., van de Berg, Pablo, van den Berg, Alida E., Bergmans, Dennis C.J.J., van den Bersselaar, Dido I., Bertens, Freke A., Bindels, Alexander J.G.H., de Boer, Milou M., den Boer, Sylvia, Boers, Leonoor S., Bogerd, Margriet, Bos, Lieuwe D.J., Botta, Michela, Breel, Jennifer S., de Bruin, Hendrik, de Bruin, Sanne, Bruna, Caro L., Buiteman-Kruizinga, Laura A., Cremer, Olaf L., Determann, Rogier M., Dieperink, Willem, Dongelmans, Dave A., Franke, Hildegard S., Galek-Aldridge, Michal S., de Graaff, Mart J., Hagens, Laura A., Haringman, Jasper J., van der Heide, Sebastiaan T., van der Heiden, Pim L.J., Heijnen, Nanon F.L., Hiel, Stephan J.P., Hoeijmakers, Lotte L., Hol, Liselotte, Hollmann, Markus W., Hoogendoorn, Marga E., Horn, Janneke, van der Horst, Robrecht, Ie, Evy L.K., Ivanov, Dimitri P., Juffermans, Nicole, Kho, Eline, de Klerk, Eline S., Koopman-van Gemert, Ankie W.M.M., Koopmans, Matty, Kucukcelebi, Songul, Kuiper, Michael A., de Lange, Dylan W., van Mourik, Niels, Nijbroek, Sunny G.L.H., Onrust, Marisa, Oostdijk, Evelien A.N., Paulus, Frederique, Pennartz, Charlotte J., Pillay, Janesh, Pisani, Luigi, Purmer, Ilse M., Rettig, Thijs C.D., Roozeman, Jan-Paul, Schuijt, Michiel T.U., Schultz, Marcus J., Serpa Neto, Ary, Sleeswijk, Mengalvio E., Smit, Marry R., Spronk, Peter E., Stilma, Willemke, Strang, Aart C., Tsonas, Anissa M., Tuinman, Pieter R., Valk, Christel M.A., Veen-Schra, Felicia L., Veldhuis, Lars I., van Velzen, Patricia, van der Ven, Ward H., Vlaar, Alexander P.J., van Vliet, Peter, van der Voort, Peter H.J., van Welie, Louis, Wesselink, Henrico J.F.T., van der Wier-Lubbers, Hermien H., van Wijk, Bas, Winters, Tineke, Wong, Wing Yi, van Zanten, Arthur R.H., Tsonas, Anissa M, Boers, Leonoor S, Bos, Lieuwe D J, Dongelmans, Dave A, Hollmann, Marcus W, Vlaar, Alexander P J, Schultz, Marcus J, and Neto, Ary Serpa

Published
2021
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8. Hyperoxemia and hypoxemia impair cellular oxygenation:a study in healthy volunteers

Author

Hilderink, Bashar N., Crane, Reinier F., van den Bogaard, Bas, Pillay, Janesh, Juffermans, Nicole P., Hilderink, Bashar N., Crane, Reinier F., van den Bogaard, Bas, Pillay, Janesh, and Juffermans, Nicole P.

Abstract

Introduction: Administration of oxygen therapy is common, yet there is a lack of knowledge on its ability to prevent cellular hypoxia as well as on its potential toxicity. Consequently, the optimal oxygenation targets in clinical practice remain unresolved. The novel PpIX technique measures the mitochondrial oxygen tension in the skin (mitoPO2) which allows for non-invasive investigation on the effect of hypoxemia and hyperoxemia on cellular oxygen availability. Results: During hypoxemia, SpO2 was 80 (77–83)% and PaO2 45(38–50) mmHg for 15 min. MitoPO2 decreased from 42(35–51) at baseline to 6(4.3–9)mmHg (p < 0.001), despite 16(12–16)% increase in cardiac output which maintained global oxygen delivery (DO2). During hyperoxic breathing, an FiO2 of 40% decreased mitoPO2 to 20 (9–27) mmHg. Cardiac output was unaltered during hyperoxia, but perfused De Backer density was reduced by one-third (p < 0.01). A PaO2 < 100 mmHg and > 200 mmHg were both associated with a reduction in mitoPO2. Conclusions: Hypoxemia decreases mitoPO2 profoundly, despite complete compensation of global oxygen delivery. In addition, hyperoxemia also decreases mitoPO2, accompanied by a reduction in microcirculatory perfusion. These results suggest that mitoPO2 can be used to titrate oxygen support.

Published
2024

13. SARS-CoV-2 Affects Thyroid and Adrenal Glands: An 18F-FDG PET/CT Study

Author

Lauri, Chiara, primary, Campagna, Giuseppe, additional, Glaudemans, Andor W. J. M., additional, Slart, Riemer H. J. A., additional, van Leer, Bram, additional, Pillay, Janesh, additional, Colandrea, Marzia, additional, Grana, Chiara Maria, additional, Stigliano, Antonio, additional, and Signore, Alberto, additional

Published
2023
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15. A simulation of skin mitochondrial Po2 in circulatory shock

Author

Hilderink, Bashar N., primary, Crane, Reinier F., additional, Baysan, Meryem, additional, Arbous, Sesmu M., additional, van den Bogaard, Bas, additional, Mik, Egbert G., additional, Ince, Can, additional, Pillay, Janesh, additional, and Juffermans, Nicole P., additional

Published
2023
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16. SARS-CoV-2 Affects Thyroid and Adrenal Glands: An 18 F-FDG PET/CT Study.

Author

Lauri, Chiara, Campagna, Giuseppe, Glaudemans, Andor W. J. M., Slart, Riemer H. J. A., van Leer, Bram, Pillay, Janesh, Colandrea, Marzia, Grana, Chiara Maria, Stigliano, Antonio, and Signore, Alberto

Subjects
ADRENAL glands, THYROIDITIS, THYROID gland, COVID-19, SARS-CoV-2, ENDOCRINE glands
Abstract

Background: Since most endocrine glands express ACE-2 receptors and can be infected by SARS-CoV-2 virus, this retrospective multicentre observational study aims to assess the metabolic activity of thyroid and adrenal glands of COVID-19 patients by 18F-FDG PET/CT. Methods: We retrospectively evaluated the 18F-FDG PET/CT scans of COVID-19 patients admitted by three different centres, either in a low-intensity department or in the intensive care unit (ICU). A visual assessment and a semi-quantitative evaluation of areas of interest in thyroid and adrenal glands were performed by recording SUVmax and SUVmean. The 18F-FDG PET/CT uptake in COVID-19 patients was compared with those observed in normal age-matched controls. Results: Between March 2020 and March 2022, 33 patients from three different centres (twenty-eight patients in a low-intensity department and five patients in ICU), were studied by 18F-FDG PET/CT during active illness. Seven of them were also studied after clinical remission (3–6 months after disease onset). Thirty-six normal subjects were used as age-matched controls. In the thyroid gland, no statistically significant differences were observed between control subjects and COVID-19 patients at diagnosis. However, at the follow-up PET/CT study, we found a statistically higher SUVmax and SUVmean (p = 0.009 and p = 0.004, respectively) in the thyroid of COVID-19 patients. In adrenal glands, we observed lower SUVmax and SUVmean in COVID-19 patients at baseline compared to control subjects (p < 0.0001) and this finding did not normalize after clinical recovery (p = 0.0018 for SUVmax and p = 0.002 for SUV mean). Conclusions: In our series, we observed persistent low 18F-FDG uptake in adrenal glands of patients at diagnosis of COVID-19 and after recovery, suggesting a chronic hypofunction. By contrast, thyroid uptake was comparable to normal subjects at disease onset, but after recovery, a subgroup of patients showed an increased metabolism, thus possibly suggesting the onset of an inflammatory thyroiditis. Our results should alert clinicians to investigate the pituitary–adrenal axis and thyroid functionality at the time of infection and to monitor them after recovery. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Optimal dosing and timing of high-dose corticosteroid therapy in hospitalized COVID-19 patients: study protocol for a retrospective observational multicenter study (SELECT) (Preprint)

Author

Daenen, Katrijn, primary, Huijben, Jilske, additional, Boyd, Anders, additional, Bos, Lieuwe, additional, Stoof, Sara, additional, van Willigen, Hugo, additional, Gommers, Diederik, additional, Moeniralam, Hazra, additional, den Uil, Corstiaan, additional, Juffermans, Nicole, additional, Kant, Merijn, additional, Valkenburg, Bram, additional, Pillay, Janesh, additional, van Meenen, David, additional, Paulus, Frederique, additional, Schultz, Marcus, additional, Dalm, Virgil, additional, van Gorp, Eric, additional, Schinkel, Janke, additional, and Endeman, Henrik, additional

Published
2023
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18. Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19:Study Protocol for a Retrospective Observational Multicenter Study (SELECT)

Author

Daenen, Katrijn, Huijben, Jilske A., Boyd, Anders, Bos, Lieuwe D.J., Stoof, Sara C.M., van Willigen, Hugo, Gommers, Diederik A.M.P.J., Moeniralam, Hazra S., den Uil, Corstiaan A., Juffermans, Nicole P., Kant, Merijn, Valkenburg, Abraham J., Pillay, Janesh, van Meenen, David M.P., Paulus, Frederique, Schultz, Marcus J., Dalm, Virgil A.S.H., van Gorp, Eric C.M., Schinkel, Janke, Endeman, Henrik, Daenen, Katrijn, Huijben, Jilske A., Boyd, Anders, Bos, Lieuwe D.J., Stoof, Sara C.M., van Willigen, Hugo, Gommers, Diederik A.M.P.J., Moeniralam, Hazra S., den Uil, Corstiaan A., Juffermans, Nicole P., Kant, Merijn, Valkenburg, Abraham J., Pillay, Janesh, van Meenen, David M.P., Paulus, Frederique, Schultz, Marcus J., Dalm, Virgil A.S.H., van Gorp, Eric C.M., Schinkel, Janke, and Endeman, Henrik

Abstract

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose corticosteroids are often administered as salvage late in the disease course, whereas earlier administration may be more beneficial in preventing disease progression. Previous research has revealed that increased levels of various biomarkers are associated with mortality, and whole blood transcriptome sequencing has the ability to identify host factors predisposing to critical illness in patients with COVID-19. Objective: Our goal is to determine the most optimal dosing and timing of corticosteroid therapy and to provide a basis for personalized corticosteroid treatment regimens to reduce morbidity and mortality in hospitalized patients with COVID-19. Methods: This is a retrospective, observational, multicenter study that includes adult patients who were hospitalized due to COVID-19 in the Netherlands. We will use the differences in therapeutic strategies between hospitals (per protocol high-dose corticosteroids or not) over time to determine whether high-dose corticosteroids have an effect on the following outcome measures: mechanical ventilation or high-flow nasal cannula therapy, in-hospital mortality, and 28-day survival. We will also explore biomarker profiles in serum and bronchoalveolar lavage fluid and use whole blood transcriptome analysis to determine factors that influence the relationship between high-dose corticosteroids and outcome. Existing databases that contain routinely collected electronic data during ward and intensive care admissions, as well as existing biobanks, will be used. We will apply longitudinal modeling appropriate for each data structure to answer the research questions at hand. Results: As of April 2023, data have been collected f

Published
2023

22. 18F-fluorodeoxyglucose positron emission tomography/computed tomography differentiates between pneumonia and atelectasis in a mechanically ventilated patient.

Author

Flanderijn, Marthe, van Leer, Bram, Slart, Riemer H. J. A., and Pillay, Janesh

Subjects
VENTILATOR-associated pneumonia, POSITRON emission tomography, INFORMED consent (Medical law), COMPUTED tomography, MULTIPLE organ failure
Abstract

This article discusses the challenges of differentiating between atelectasis and pneumonia in critically ill patients using regular computed tomography (CT). The study demonstrates the additional value of a 18F-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) scan in distinguishing between the two conditions. The scan was performed on a 61-year-old male patient with multiple organ failure, and the results showed normal physiological uptake in the myocardium, bilateral pleural effusion, and atelectasis with elevated [18F]FDG uptake in the left and right lower lobes. The high [18F]FDG uptake in the right lower lobe indicated an infectious focus, which was confirmed by a subsequent positive sputum culture. The article highlights the potential of [18F]FDG PET/CT in differentiating between infectious and inflammatory pulmonary abnormalities in critically ill patients. [Extracted from the article]

Published
2024
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23. Association of early positive end-expiratory pressure settings with ventilator-free days in patients with coronavirus disease 2019 acute respiratory distress syndrome

Author

Valk, Christel M.A., Tsonas, Anissa M., Botta, Michela, Bos, Lieuwe D.J., Pillay, Janesh, Serpa Neto, Ary, Schultz, Marcus J., and Paulus, Frederique

Subjects
Positive-Pressure Respiration, Respiratory Distress Syndrome, Ventilators, Mechanical, SARS-CoV-2, COVID-19, Humans, Covid 19, Retrospective Studies
Abstract

BACKGROUND There is uncertainty about how much positive end-expiratory pressure (PEEP) should be used in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). OBJECTIVE To investigate whether a higher PEEP strategy is superior to a lower PEEP strategy regarding the number of ventilator-free days (VFDs). DESIGN Multicentre observational study conducted from 1 March to 1 June 2020. SETTING AND PATIENTS Twenty-two ICUs in The Netherlands and 933 invasively ventilated COVID-19 ARDS patients. INTERVENTIONS Patients were categorised retrospectively as having received invasive ventilation with higher (n=259) or lower PEEP (n=674), based on the high and low PEEP/FiO2 tables of the ARDS Network, and using ventilator settings and parameters in the first hour of invasive ventilation, and every 8 h thereafter at fixed time points during the first four calendar days. We also used propensity score matching to control for observed confounding factors that might influence outcomes. MAIN OUTCOMES AND MEASURES The primary outcome was the number of VFDs. Secondary outcomes included distant organ failures including acute kidney injury (AKI) and use of renal replacement therapy (RRT), and mortality. RESULTS In the unmatched cohort, the higher PEEP strategy had no association with the median [IQR] number of VFDs (2.0 [0.0 to 15.0] vs. 0.0 [0.0 to 16.0] days). The median (95% confidence interval) difference was 0.21 (−3.34 to 3.78) days, P = 0.905. In the matched cohort, the higher PEEP group had an association with a lower median number of VFDs (0.0 [0.0 to 14.0] vs. 6.0 [0.0 to 17.0] days) a median difference of −4.65 (−8.92 to −0.39) days, P = 0.032. The higher PEEP strategy had associations with higher incidence of AKI (in the matched cohort) and more use of RRT (in the unmatched and matched cohorts). The higher PEEP strategy had no association with mortality. CONCLUSION In COVID-19 ARDS, use of higher PEEP may be associated with a lower number of VFDs, and may increase the incidence of AKI and need for RRT. TRIAL REGISTRATION Practice of VENTilation in COVID-19 is registered at ClinicalTrials.gov, NCT04346342.

Published
2021

25. A simulation of skin mitochondrial Po2 in circulatory shock.

Author

Hilderink, Bashar N., Crane, Reinier F., Baysan, Meryem, Arbous, Sesmu M., van den Bogaard, Bas, Mik, Egbert G., Ince, Can, Pillay, Janesh, and Juffermans, Nicole P.

Subjects
CARDIOGENIC shock, FLOW velocity, BLOOD flow, MITOCHONDRIA, SEPTIC shock
Abstract

Circulatory shock is the inadequacy to supply mitochondria with enough oxygen to sustain aerobic energy metabolism. A novel noninvasive bedside measurement was recently introduced to monitor the mitochondrial oxygen tension in the skin (mitoP o2). As the most downstream marker of oxygen balance in the skin, mitoPo2 may provide additional information to improve shock management. However, a physiological basis for the interpretation of mitoPo2 values has not been established yet. In this paper, we developed a mathematical model of skin mitoPo2 using a network of parallel microvessels, based on Krogh's cylinder model. The model contains skin blood flow velocity, heterogeneity of blood flow, hematocrit, arteriolar oxygen saturation, and mitochondrial oxygen consumption as major variables. The major results of the model show that normal physiological mitoPo2 is in the range of 40-60 mmHg. The relationship of mitoPo2 with skin blood flow velocity follows a logarithmic growth curve, reaching a plateau at high skin blood flow velocity, suggesting that oxygen balance remains stable while peripheral perfusion declines. The model shows that a critical range exists where mitoPo2 rapidly deteriorates if skin perfusion further decreases. The model intuitively shows how tissue hypoxia could occur in the setting of septic shock, due to the profound impact of microcirculatory disturbance on mitoPo2, even at sustained cardiac output. MitoPo2 is the result of a complex interaction between all factors of oxygen delivery and microcirculation. This mathematical framework can be used to interpret mitoPo2 values in shock, with the potential to enhance personalized clinical trial design. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

Author

Botta, Michela, Tsonas, Anissa M., Pillay, Janesh, Boers, Leonoor S., Algera, Anna Geke, Bos, Lieuwe D. J., Dongelmans, Dave A., Hollmann, Marcus W., Horn, Janneke, Vlaar, Alexander P. J., Schultz, Marcus J., Neto, Ary Serpa, Paulus, Frederique, PRoVENT-COVID Collaborative Group, Bergmans, Dennis, Botta, Michela, Tsonas, Anissa M., Pillay, Janesh, Boers, Leonoor S., Algera, Anna Geke, Bos, Lieuwe D. J., Dongelmans, Dave A., Hollmann, Marcus W., Horn, Janneke, Vlaar, Alexander P. J., Schultz, Marcus J., Neto, Ary Serpa, Paulus, Frederique, PRoVENT-COVID Collaborative Group, and Bergmans, Dennis

Abstract

Background Little is known about the practice of ventilation management in patients with COVID-19. We aimed to describe the practice of ventilation management and to establish outcomes in invasively ventilated patients with COVID-19 in a single country during the first month of the outbreak.Methods PRoVENT-COVID is a national, multicentre, retrospective observational study done at 18 intensive care units (ICUs) in the Netherlands. Consecutive patients aged at least 18 years were eligible for participation if they had received invasive ventilation for COVID-19 at a participating ICU during the first month of the national outbreak in the Netherlands. The primary outcome was a combination of ventilator variables and parameters over the first 4 calendar days of ventilation: tidal volume, positive end-expiratory pressure (PEEP), respiratory system compliance, and driving pressure. Secondary outcomes included the use of adjunctive treatments for refractory hypoxaemia and ICU complications. Patient-centred outcomes were ventilator-free days at day 28, duration of ventilation, duration of ICU and hospital stay, and mortality. PRoVENT-COVID is registered at ClinicalTrials.gov (NCT04346342).Findings Between March 1 and April 1, 2020, 553 patients were included in the study. Median tidal volume was 6.3 mL/kg predicted bodyweight (IQR 5.7-7.1), PEEP was 14.0 cm H2O (IQR 11.0-15.0), and driving pressure was 14.0 cm H 2O (11.2-16.0). Median respiratory system compliance was 31.9 mL/cm H 2O (26.0-39.9). Of the adjunctive treatments for refractory hypoxaemia, prone positioning was most often used in the first 4 days of ventilation (283 [53%] of 530 patients). The median number of ventilator-free days at day 28 was 0 (IQR 0-15); 186 (35%) of 530 patients had died by day 28. Predictors of 28-day mortality were gender, age, tidal volume, respiratory system compliance, arterial pH, and heart rate on the first day of invasive ventilation.Interpretation In patient

Published
2021

31. Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

Author

Infection & Immunity, Medische Staf Intensive Care, Botta, Michela, Tsonas, Anissa M, Pillay, Janesh, Boers, Leonoor S, Algera, Anna Geke, Bos, Lieuwe D J, Dongelmans, Dave A, Hollmann, Marcus W, Horn, Janneke, Vlaar, Alexander P J, Schultz, Marcus J, Neto, Ary Serpa, Paulus, Frederique, PRoVENT-COVID Collaborative Group, Infection & Immunity, Medische Staf Intensive Care, Botta, Michela, Tsonas, Anissa M, Pillay, Janesh, Boers, Leonoor S, Algera, Anna Geke, Bos, Lieuwe D J, Dongelmans, Dave A, Hollmann, Marcus W, Horn, Janneke, Vlaar, Alexander P J, Schultz, Marcus J, Neto, Ary Serpa, Paulus, Frederique, and PRoVENT-COVID Collaborative Group

Published
2021

32. A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

Author

Pillay, Janesh, Kamp, Vera M., Van Hoffen, Els, Visser, Tjaakje, Tak, Tamar, Lammers, Jan-Willem, Ulfman, Laurien H., Leenen, Luke P., Pickkers, Peter, and Koenderman, Leo

Subjects
T cells -- Physiological aspects -- Research, Bone marrow -- Transplantation, Immune response -- Research, Cancer -- Diagnosis -- Risk factors -- Research -- Care and treatment, Health care industry
Abstract

Suppression of immune responses is necessary to limit damage to host tissue during inflammation, but it can be detrimental in specific immune responses, such as sepsis and antitumor immunity. Recently, immature myeloid cells have been implicated in the suppression of immune responses in mouse models of cancer, infectious disease, bone marrow transplantation, and autoimmune disease. Here, we report the identification of a subset of mature human neutrophils (CD11[c.sup.bright]/CD62[L.sup.dim]/CD11[b.sup.bright]/CD[16.sup.bright]) as what we believe to be a unique circulating population of myeloid cells, capable of suppressing human T cell proliferation. These cells were observed in humans in vivo during acute systemic inflammation induced by endotoxin challenge or by severe injury. Local release of hydrogen peroxide from the neutrophils into the immunological synapse between the neutrophils and T cells mediated the suppression of T cell proliferation and required neutrophil expression of the integrin Mac-1 (αM[bata]2). Our data demonstrate that suppression of T cell function can be accomplished by a subset of human neutrophils that can be systemically induced in response to acute inflammation. Identification of the pivotal role of neutrophil Mac-1 and ROS in this process provides a potential target for modulating immune responses in humans., Introduction Immune suppression is essential in immune regulation, but can be detrimental in various pathological conditions. Classically, lymphoid cells play a major role in regulating immune responses. Recently, however, a [...]

Published
2012
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33. Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

Author

Botta, Michela, primary, Tsonas, Anissa M, additional, Pillay, Janesh, additional, Boers, Leonoor S, additional, Algera, Anna Geke, additional, Bos, Lieuwe D J, additional, Dongelmans, Dave A, additional, Hollmann, Marcus W, additional, Horn, Janneke, additional, Vlaar, Alexander P J, additional, Schultz, Marcus J, additional, Neto, Ary Serpa, additional, Paulus, Frederique, additional, van Akkeren, Jesse P., additional, Algoe, Cheetel K., additional, van Amstel, Rombout B., additional, Baur, Onno L., additional, van de Berg, Pablo, additional, van den Berg, Alida E., additional, Bergmans, Dennis C.J.J., additional, van den Bersselaar, Dido I., additional, Bertens, Freke A., additional, Bindels, Alexander J.G.H., additional, de Boer, Milou M., additional, den Boer, Sylvia, additional, Boers, Leonoor S., additional, Bogerd, Margriet, additional, Bos, Lieuwe D.J., additional, Botta, Michela, additional, Breel, Jennifer S., additional, de Bruin, Hendrik, additional, de Bruin, Sanne, additional, Bruna, Caro L., additional, Buiteman-Kruizinga, Laura A., additional, Cremer, Olaf L., additional, Determann, Rogier M., additional, Dieperink, Willem, additional, Dongelmans, Dave A., additional, Franke, Hildegard S., additional, Galek-Aldridge, Michal S., additional, de Graaff, Mart J., additional, Hagens, Laura A., additional, Haringman, Jasper J., additional, van der Heide, Sebastiaan T., additional, van der Heiden, Pim L.J., additional, Heijnen, Nanon F.L., additional, Hiel, Stephan J.P., additional, Hoeijmakers, Lotte L., additional, Hol, Liselotte, additional, Hollmann, Markus W., additional, Hoogendoorn, Marga E., additional, van der Horst, Robrecht, additional, Ie, Evy L.K., additional, Ivanov, Dimitri P., additional, Juffermans, Nicole, additional, Kho, Eline, additional, de Klerk, Eline S., additional, Koopman-van Gemert, Ankie W.M.M., additional, Koopmans, Matty, additional, Kucukcelebi, Songul, additional, Kuiper, Michael A., additional, de Lange, Dylan W., additional, van Mourik, Niels, additional, Nijbroek, Sunny G.L.H., additional, Onrust, Marisa, additional, Oostdijk, Evelien A.N., additional, Pennartz, Charlotte J., additional, Pisani, Luigi, additional, Purmer, Ilse M., additional, Rettig, Thijs C.D., additional, Roozeman, Jan-Paul, additional, Schuijt, Michiel T.U., additional, Schultz, Marcus J., additional, Serpa Neto, Ary, additional, Sleeswijk, Mengalvio E., additional, Smit, Marry R., additional, Spronk, Peter E., additional, Stilma, Willemke, additional, Strang, Aart C., additional, Tsonas, Anissa M., additional, Tuinman, Pieter R., additional, Valk, Christel M.A., additional, Veen-Schra, Felicia L., additional, Veldhuis, Lars I., additional, van Velzen, Patricia, additional, van der Ven, Ward H., additional, Vlaar, Alexander P.J., additional, van Vliet, Peter, additional, van der Voort, Peter H.J., additional, van Welie, Louis, additional, Wesselink, Henrico J.F.T., additional, van der Wier-Lubbers, Hermien H., additional, van Wijk, Bas, additional, Winters, Tineke, additional, Wong, Wing Yi, additional, and van Zanten, Arthur R.H., additional

Published
2021
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34. PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID): rationale and protocol for a national multicenter observational study in The Netherlands

Author

Boers, Noor S, Botta, Michela, Tsonas, Annisa M, Algera, Anna Geke, Pillay, Janesh, Dongelmans, Dave A, Horn, Janneke, Vlaar, Alexander P J, Hollmann, Markus W, Bos, Lieuwe D J, Paulus, Frederique, Neto, Ary Serpa, Schultz, Marcus J, de Klerk, Eline S., Lectoraat Critical Care, Urban Vitality, Faculteit Gezondheid, Intensive Care Medicine, Graduate School, AII - Inflammatory diseases, ACS - Microcirculation, Anesthesiology, ACS - Heart failure & arrhythmias, Nursing, ACS - Atherosclerosis & ischemic syndromes, APH - Quality of Care, ACS - Pulmonary hypertension & thrombosis, and ACS - Diabetes & metabolism

Subjects
medicine.medical_specialty, medicine.medical_treatment, mechanical ventilation, critical care medicine, Hypoxemia, law.invention, 03 medical and health sciences, the coronavirus disease 2019 (COVID-19), 0302 clinical medicine, law, Intensive care, Health care, Pandemic, medicine, Extracorporeal membrane oxygenation, 030212 general & internal medicine, Mechanical ventilation, ventilator-free days, business.industry, SARS-CoV-2, General Medicine, EVOLUTION, Study Protocal, 030228 respiratory system, Emergency medicine, Ventilation (architecture), Observational study, medicine.symptom, business
Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic is rapidly expanding across the world, with more than 100,000 new cases each day as of end-June 2020. Healthcare workers are struggling to provide the best care for COVID-19 patients. Approaches for invasive ventilation vary widely between and within countries and new insights are acquired rapidly. We aim to investigate invasive ventilation practices and outcome in COVID-19 patients in the Netherlands.Methods: PRoVENT-COVID ('study of PRactice of VENTilation in COVID-19') is an investigator-initiated national, multicenter observational study to be undertaken in intensive care units (ICUs) in The Netherlands. Consecutive COVID-19 patients aged 18 years or older, who are receiving invasive ventilation in the participating ICUs, are to be enrolled during a 10-week period, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cmH2O) during the first 3 days of ventilation. Secondary outcomes include other ventilatory variables, use of rescue therapies for refractory hypoxemia such as prone positioning and extracorporeal membrane oxygenation, use of sedatives, vasopressors and inotropes; daily cumulative fluid balances; acute kidney injury; ventilator-free days and alive at day 28 (VFD-28), duration of ICU and hospital stay, and ICU, hospital and 90-day mortality.Discussion: PRoVENT-COVID will be the largest observational study to date, with high density ventilatory data and major outcomes. There is urgent need for a better understanding of ventilation practices, and the effects of ventilator settings on outcomes in COVID-19 patients. The results of PRoVENT-COVID will be rapidly disseminated through electronic presentations, such as webinars and electronic conferences, and publications in international peer-reviewed journals. Access to source data will be made available through local, regional and national anonymized datasets on request, and after agreement of the PRoVENT-COVID steering committee.Trial Registration: PRoVENT-COVID is registered at clinicaltrials.gov (identifier NCT04346342).

Published
2020

36. Effect of the CXCR4 antagonist plerixafor on endogenous neutrophil dynamics in the bone marrow, lung and spleen

Author

Pillay, Janesh, primary, Tregay, Nicola, additional, Juzenaite, Goda, additional, Carlin, Leo M., additional, Pirillo, Chiara, additional, Gaboriau, David C. A., additional, Farahi, Neda, additional, Summers, Charlotte, additional, Lo Celso, Cristina, additional, Chilvers, Edwin R., additional, Rankin, Sara, additional, and De Filippo, Katia, additional

Published
2020
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39. Differential antibacterial control by neutrophil subsets

Author

Leliefeld, Pieter H C, Pillay, Janesh, Vrisekoop, Nienke, Heeres, Marjolein, Tak, Tamar, Kox, Matthijs, Rooijakkers, Suzan H M, Kuijpers, Taco W, Pickkers, Peter, Leenen, Luke P H, Koenderman, Leo, Leliefeld, Pieter H C, Pillay, Janesh, Vrisekoop, Nienke, Heeres, Marjolein, Tak, Tamar, Kox, Matthijs, Rooijakkers, Suzan H M, Kuijpers, Taco W, Pickkers, Peter, Leenen, Luke P H, and Koenderman, Leo

Published
2018

41. Differential antibacterial control by neutrophil subsets

Author

Infection & Immunity, Heelkunde Opleiding, AIOS Anesthesiologie, Experimentele Afdeling Longziekten, MMB Research line 1, Zorgeenheid Traumatologie, Cancer, Leliefeld, Pieter H C, Pillay, Janesh, Vrisekoop, Nienke, Heeres, Marjolein, Tak, Tamar, Kox, Matthijs, Rooijakkers, Suzan H M, Kuijpers, Taco W, Pickkers, Peter, Leenen, Luke P H, Koenderman, Leo, Infection & Immunity, Heelkunde Opleiding, AIOS Anesthesiologie, Experimentele Afdeling Longziekten, MMB Research line 1, Zorgeenheid Traumatologie, Cancer, Leliefeld, Pieter H C, Pillay, Janesh, Vrisekoop, Nienke, Heeres, Marjolein, Tak, Tamar, Kox, Matthijs, Rooijakkers, Suzan H M, Kuijpers, Taco W, Pickkers, Peter, Leenen, Luke P H, and Koenderman, Leo

Published
2018

42. Differential antibacterial control by neutrophil subsets

Author

Leliefeld, Pieter H. C., primary, Pillay, Janesh, additional, Vrisekoop, Nienke, additional, Heeres, Marjolein, additional, Tak, Tamar, additional, Kox, Matthijs, additional, Rooijakkers, Suzan H. M., additional, Kuijpers, Taco W., additional, Pickkers, Peter, additional, Leenen, Luke P. H., additional, and Koenderman, Leo, additional

Published
2018
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45. The role of neutrophils in immune dysfunction during severe inflammation

Author

Infection & Immunity, Heelkunde Opleiding, Zorgeenheid Traumatologie, Experimentele Afdeling Longziekten, Cancer, AIOS Anesthesiologie, Other research (not in main researchprogram), Leliefeld, Pieter H C, Wessels, Catharina M, Leenen, Luke P H, Koenderman, Leo, Pillay, Janesh, Infection & Immunity, Heelkunde Opleiding, Zorgeenheid Traumatologie, Experimentele Afdeling Longziekten, Cancer, AIOS Anesthesiologie, Other research (not in main researchprogram), Leliefeld, Pieter H C, Wessels, Catharina M, Leenen, Luke P H, Koenderman, Leo, and Pillay, Janesh

Published
2016

48. How Neutrophils Shape Adaptive Immune Responses

Author

Zorgeenheid Traumatologie, Infection & Immunity, Experimentele Afdeling Longziekten, Cancer, AIOS Anesthesiologie, Other research (not in main researchprogram), Leliefeld, Pieter H C, Koenderman, Leo, Pillay, Janesh, Zorgeenheid Traumatologie, Infection & Immunity, Experimentele Afdeling Longziekten, Cancer, AIOS Anesthesiologie, Other research (not in main researchprogram), Leliefeld, Pieter H C, Koenderman, Leo, and Pillay, Janesh

Published
2015

49. Neutrophils in respiratory syncytial virus infection: A target for asthma prevention

Author

Child Health, Infection & Immunity, CTI Meyaard, AIOS Anesthesiologie, Other research (not in main researchprogram), Geerdink, Ruben J., Pillay, Janesh, Meyaard, Linde, Bont, LJ, Child Health, Infection & Immunity, CTI Meyaard, AIOS Anesthesiologie, Other research (not in main researchprogram), Geerdink, Ruben J., Pillay, Janesh, Meyaard, Linde, and Bont, LJ

Published
2015

50. The in vivo half-life of human neutrophils: Response

Author

Pillay, Janesh, den Braber, Ineke, Vrisekoop, Nienke, Kwast, Lydia M., de Boer, Rob J., Borghans, Jose A. M., Tesselaar, Kiki, Koenderman, Leo, and University of Groningen

Subjects
CELLS, PROLIFERATION, DNA, KINETICS
Published
2011

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