Search

Your search keyword '"Pilkington, Clarissa A."' showing total 527 results
Start Over Author "Pilkington, Clarissa A."
527 results on '"Pilkington, Clarissa A."'

1. Juvenile Dermatomyositis

Author

Pachman, Lauren M., Tansley, Sarah, Reed, Ann M., Pilkington, Clarissa M., Feldman, Brian M., Rider, Lisa G., and Stone, John H., editor

Published
2023
Full Text
View/download PDF

2. Proposed Response Parameters for Twelve‐Month Drug Trial in Juvenile Systemic Sclerosis: Results of the Hamburg International Consensus Meetings

Author

Foeldvari, Ivan, Torok, Kathryn S., Anton, Jordi, Blakley, Michael, Constantin, Tamás, Curran, Megan, Cutolo, Maurizio, Denton, Christopher, Fligelstone, Kim, Ingegnoli, Francesca, Li, Suzanne C., Němcová, Dana, Orteu, Catherine, Pilkington, Clarissa, Smith, Vanessa, Stevens, Anne, Klotsche, Jens, Khanna, Dinesh, Costa‐Reis, Patrícia, Del Galdo, Francesco, Hinrichs, Bernd, Kasapcopur, Ozgur, Pain, Clare, Ruperto, Nicolino, Zheng, Alison, and Furst, Daniel E.

Published
2023
Full Text
View/download PDF

3. Real world treatment of juvenile-onset systemic lupus erythematosus: Data from the UK JSLE cohort study

Author

Smith, Eve M.D., Egbivwie, Naomi, Jorgensen, Andrea L., Ciurtin, Coziana, Al-Abadi, Eslam, Armon, Kate, Bailey, Kathryn, Brennan, Mary, Gardner-Medwin, Janet, Haslam, Kirsty, Hawley, Daniel P., Leahy, Alice, Leone, Valentina, Malik, Gulshan, McLaren, Zoe, Pilkington, Clarissa, Ramanan, Athimalaipet V., Rangaraj, Satyapal, Ratcliffe, Annie, Riley, Phil, Sen, Ethan, Sridhar, Arani, Wilkinson, Nick, Wood, Fiona, Beresford, Michael W., and Hedrich, Christian M.

Published
2022
Full Text
View/download PDF

4. OA36 Systemic juvenile idiopathic arthritis: the Great Ormond Street Hospital experience (2005-2021)

Author

Foley, Charlene Majella, primary, McKenna, Dearbhla, additional, Gallagher, Kathy, additional, McLellan, Kirsty, additional, Alkhdher, Hanof, additional, Lacassagne, Sandrine, additional, Moraitis, Elena, additional, Papadopoulou, Charalampia, additional, Pilkington, Clarissa, additional, Al Obaidi, Muthana, additional, Eleftheriou, Despina, additional, and Brogan, Paul, additional

Published
2024
Full Text
View/download PDF

5. Mental health in paediatric and adult myositis-related diseases: current state of research, interventions, and future steps from the MIHRA Psychological Impact Scientific Working Group

Author

Lanis, Aviya, primary, Alexanderson, Helene, additional, Ardalan, Kaveh, additional, Edison, Suzanne, additional, Graham, Christopher D., additional, de Groot, Ingrid, additional, Gupta, Latika, additional, Kim, Susan, additional, Knight, Andrea M., additional, Kobert, Linda, additional, Livermore, Polly, additional, Lood, Christian, additional, Pilkington, Clarissa, additional, Regardt, Malin, additional, Rubinstein, Tamar B., additional, Shenoi, Susan, additional, Turnier, Luke, additional, Voet, Nicole B.M., additional, Wahezi, Dawn M., additional, and Saketkoo, Lesley Ann, additional

Published
2024
Full Text
View/download PDF

6. Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts

Author

Campion, Dominique, Dartigues, Jean-Francois, Deleuze, Jean-François, Genin, Emmanuelle, Lambert, Jean-Charles, Redon, Richard, Allain-Launay, Emma, Bader-Meunier, Brigitte, Belot, Alexandre, Bouayed, Kenza, Burtey, Stephane, Carbasse, Aurélia, Decramer, Stéphane, Despert, Véronique, Fain, Olivier, Fischbach, Michel, Flodrops, Hugues, Galeotti, Caroline, Hachulla, Eric, Hatchuel, Yves, Kleinmann, Jean-Francois, Kone-Paut, Isabelle, Lanteri, Aurélia, Lemelle, Irène, Maillard, Hélène, Maurier, François, Meinzer, Ulrich, Melki, Isabelle, Morell-Dubois, Sandrine, Pagnier, Anne, Piram, Maryam, Ranchin, Bruno, Reumaux, Héloise, Samaille, Charlotte, Sibilia, Jean, Weill, Olivia, Al-Abadi, Eslam, Armon, Kate, Bailey, Kathryn, Beresford, Michael, Brennan, Mary, Ciurtin, Coziana, Gardner-Medwin, Janet, Haslam, Kirsty, Hawley, Daniel, Leahy, Alice, Leone, Valentina, Mewar, Devesh, Moots, Rob, Pilkington, Clarissa, Ramanan, Athimalaipet, Rangaraj, Satyapal, Ratcliffe, Annie, Riley, Philip, Sen, Ethan, Sridhar, Arani, Wilkinson, Nick, Wood, Fiona, Rice, Gillian I, Omarjee, Sulliman Ommar, Rouchon, Quentin, Smith, Eve M D, Moreews, Marion, Tusseau, Maud, Frachette, Cécile, Bournhonesque, Raphael, Thielens, Nicole, Gaboriaud, Christine, Rouvet, Isabelle, Chopin, Emilie, Hoshino, Akihiro, Latour, Sylvain, Cimaz, Rolando, Romagnani, Paula, Malcus, Christophe, Fabien, Nicole, Sarda, Marie-Nathalie, Kassai, Behrouz, Lega, Jean-Christophe, Abou-Jaoude, Pauline, Bruce, Ian N, Simonet, Thomas, Bardel, Claire, Rollat-Farnier, Pierre Antoine, Viel, Sebastien, O'Sullivan, James, Walzer, Thierry, Mathieu, Anne-Laure, Marenne, Gaelle, Ludwig, Thomas, Ellingford, Jamie, Briggs, Tracy A, Beresford, Michael W, and Crow, Yanick J

Published
2020
Full Text
View/download PDF

7. Best clinical practice in the treatment of juvenile systemic sclerosis: expert panel guidance - the result of the International Hamburg Consensus Meeting December 2022

Author

Foeldvari, Ivan, primary, Torok, Kathryn S., additional, Antón, Jordi, additional, Blakley, Michael, additional, Constantin, Tamás, additional, Cutolo, Maurizio, additional, Denton, Christopher P., additional, Fligelstone, Kim, additional, Hinrichs, Bernd, additional, Li, Suzanne C., additional, Maillard, Susan, additional, Marrani, Edoardo, additional, Moinzadeh, Pia, additional, Orteu, Catherine H., additional, Pain, Clare E., additional, Pauling, John D, additional, Pilkington, Clarissa, additional, Rosser, Franziska, additional, Smith, Vanessa, additional, and Furst, Daniel F, additional

Published
2023
Full Text
View/download PDF

9. Best clinical practice in the treatment of juvenile systemic sclerosis: expert panel guidance - the result of the International Hamburg Consensus Meeting December 2022.

Author

Foeldvari, Ivan, Torok, Kathryn S., Antón, Jordi, Blakley, Michael, Constantin, Tamás, Cutolo, Maurizio, Denton, Christopher P., Fligelstone, Kim, Hinrichs, Bernd, Li, Suzanne C., Maillard, Susan, Marrani, Edoardo, Moinzadeh, Pia, Orteu, Catherine H., Pain, Clare E., Pauling, John D., Pilkington, Clarissa, Rosser, Franziska, Smith, Vanessa, and Furst, Daniel F.

Subjects
SYSTEMIC scleroderma, BEST practices, PEDIATRIC rheumatology, RARE diseases, DISEASE prevalence
Abstract

Juvenile systemic sclerosis (jSSc) is an orphan disease with a prevalence of 3 in 1,000,000 children. Currently there is only one consensus treatment guideline concerning skin, pulmonary and vascular involvement for jSSc, the jSSc SHARE (Single Hub and Access point for pediatric Rheumatology in Europe) initiative, which was based on data procured up to 2014. Therefore, an update of these guidelines, with a more recent literature and expert experience, and extension of the guidance to more aspects of the disease is needed. Treatment options were reviewed, and opinions were provided for most facets of jSSc including general management, some of which differs from adult systemic sclerosis, such as the use of corticosteroids, and specific organ involvement, such as skin, musculoskeletal, pulmonary, and gastroenterology. We are suggesting the treat to target strategy to treat early to prevent cumulative disease damage in jSSc. Conclusions are derived from both expert opinion and available literature, which is mostly based on adult systemic sclerosis (aSSc), given shared pathophysiology, extrapolation of results from aSSc studies was judged reasonable. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Rheumatology

Author

Pilkington, Clarissa, primary, Nistala, Kiran, additional, Lachman, Helen, additional, and Brogan, Paul, additional

Published
2019
Full Text
View/download PDF

14. OA39 Development of a Childhood Lupus Low Disease Activity State definition: recommendations from the International Childhood Lupus Treat-to-Target Task Force

Author

Smith, Eve M D, primary, Aggarwal, Amita, additional, Ainsworth, Jenny, additional, Al-Abadi, Eslam, additional, Avcin, Tadej, additional, Bortey, Lynette, additional, Burnham, Jon, additional, Ciurtin, Coziana, additional, Hedrich, Christian M, additional, Kamphuis, Sylvia, additional, Levy, Deborah, additional, Lewandowski, Laura, additional, Maxwell, Naomi, additional, Morand, Eric, additional, Ozen, Seza, additional, Pain, Clare, additional, Ravelli, Angelo, additional, Saad Magalhaes, Claudia, additional, Pilkington, Clarissa, additional, Schonenberg, Dieneke, additional, Scott, Chris, additional, Tullus, Kjell, additional, and Beresford, Michael W, additional

Published
2023
Full Text
View/download PDF

15. Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus:PReS-endorsed overarching principles and points-to-consider from an international task force

Author

Smith, Eve Mary Dorothy, Aggarwal, Amita, Ainsworth, Jenny, Al-Abadi, Eslam, Avcin, Tadej, Bortey, Lynette, Burnham, Jon, Ciurtin, Coziana, Hedrich, Christian M., Kamphuis, Sylvia, Levy, Deborah M., Lewandowski, Laura B., Maxwell, Naomi, Morand, Eric F., Ozen, Seza, Pain, Clare E., Ravelli, Angelo, Saad Magalhaes, Claudia, Pilkington, Clarissa A., Schonenberg-Meinema, Dieneke, Scott, Christiaan, Tullus, Kjell, Beresford, Michael William, Smith, Eve Mary Dorothy, Aggarwal, Amita, Ainsworth, Jenny, Al-Abadi, Eslam, Avcin, Tadej, Bortey, Lynette, Burnham, Jon, Ciurtin, Coziana, Hedrich, Christian M., Kamphuis, Sylvia, Levy, Deborah M., Lewandowski, Laura B., Maxwell, Naomi, Morand, Eric F., Ozen, Seza, Pain, Clare E., Ravelli, Angelo, Saad Magalhaes, Claudia, Pilkington, Clarissa A., Schonenberg-Meinema, Dieneke, Scott, Christiaan, Tullus, Kjell, and Beresford, Michael William

Abstract

Objectives Application of 'treat-to-target' (T2T) in childhood-onset systemic lupus erythematosus (cSLE) may improve care and health outcomes. This initiative aimed to harmonise existing evidence and expert opinion regarding T2T for cSLE. Methods An international T2T Task Force was formed of specialists in paediatric rheumatology, paediatric nephrology, adult rheumatology, patient and parent representatives. A steering committee formulated a set of draft overarching principles and points-to-consider, based on evidence from systematic literature review. Two on-line preconsensus meeting Delphi surveys explored healthcare professionals' views on these provisional overarching principles and points-to-consider. A virtual consensus meeting employed a modified nominal group technique to discuss, modify and vote on each overarching principle/point-to-consider. Agreement of >80% of Task Force members was considered consensus. Results The Task Force agreed on four overarching principles and fourteen points-to-consider. It was agreed that both treatment targets and therapeutic strategies should be subject to shared decision making with the patient/caregivers, with full remission the preferred target, and low disease activity acceptable where remission cannot be achieved. Important elements of the points-to-consider included: aiming for prevention of flare and organ damage; glucocorticoid sparing; proactively addressing factors that impact health-related quality of life (fatigue, pain, mental health, educational challenges, medication side effects); and aiming for maintenance of the target over the long-term. An extensive research agenda was also formulated. Conclusions These international, consensus agreed overarching principles and points-to-consider for T2T in cSLE lay the foundation for future T2T approaches in cSLE, endorsed by the Paediatric Rheumatology European Society.

Published
2023

16. Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial

Author

Ruperto, Nicolino, Pistorio, Angela, Oliveira, Sheila, Zulian, Francesco, Cuttica, Ruben, Ravelli, Angelo, Fischbach, Michel, Magnusson, Bo, Sterba, Gary, Avcin, Tadej, Brochard, Karine, Corona, Fabrizia, Dressler, Frank, Gerloni, Valeria, Apaz, Maria T, Bracaglia, Claudia, Cespedes-Cruz, Adriana, Cimaz, Rolando, Couillault, Gerard, Joos, Rik, Quartier, Pierre, Russo, Ricardo, Tardieu, Marc, Wulffraat, Nico, Bica, Blanca, Dolezalova, Pavla, Ferriani, Virginia, Flato, Berit, Bernard-Medina, Ana G, Herlin, Troels, Trachana, Maria, Meini, Antonella, Allain-Launay, Emma, Pilkington, Clarissa, Vargova, Veronika, Wouters, Carine, Angioloni, Simona, and Martini, Alberto

Published
2016
Full Text
View/download PDF

17. Moving forward together: collaborative landscapes of research in idiopathic inflammatory myopathies and calcinosis.

Author

Saketkoo, Lesley Ann, Valenzuela, Antonia, Kim, Susan, McCann, Liza J, Lood, Christian, Wahezi, Dawn M, Werth, Victoria P, Yi, Belina, Alexanderson, Helene, Maillard, Susan, Pilkington, Clarissa, Fligelstone, Kim, Limbach, Barbara, Orandi, Amir B, Regardt, Malin, Russell, Anne-Marie, Davuluri, Srijana, deGroot, Ingrid, Ernste, Floranne, and Paik, Julie J

Subjects
MYELITIS, DERMATOMYOSITIS, INTERPROFESSIONAL relations, CALCINOSIS, SEVERITY of illness index, RESEARCH bias, MEDICAL research, RADIATION doses, SENSITIVITY & specificity (Statistics), RELIABILITY (Personality trait), DISEASE complications
Abstract

The article looks forward to opportunities for enhanced collaborative landscapes of research in idiopathic inflammatory myopathies (IIM) and calcinosis. It comments on a study which characterized the quantitative and qualitative utility of whole-body computed tomography calcium scoring technique for assessing calcinosis distribution, pattern and burden in dermatomyositis (DM) and proposed IIM-calcinosis subtypes in juvenile and adult DM.

Published
2024
Full Text
View/download PDF

18. Proposed Response Parameters for Twelve‐MonthDrug Trial in Juvenile Systemic Sclerosis: Results of the Hamburg International Consensus Meetings

Author

Foeldvari, Ivan, Torok, Kathryn S., Anton, Jordi, Blakley, Michael, Constantin, Tamás, Curran, Megan, Cutolo, Maurizio, Denton, Christopher, Fligelstone, Kim, Ingegnoli, Francesca, Li, Suzanne C., Němcová, Dana, Orteu, Catherine, Pilkington, Clarissa, Smith, Vanessa, Stevens, Anne, Klotsche, Jens, Khanna, Dinesh, Costa‐Reis, Patrícia, Del Galdo, Francesco, Hinrichs, Bernd, Kasapcopur, Ozgur, Pain, Clare, Ruperto, Nicolino, Zheng, Alison, and Furst, Daniel E.

Abstract

Juvenile systemic sclerosis (SSc) is an orphan disease, associated with high morbidity and mortality. New treatment strategies are much needed, but clearly defining appropriate outcomes is necessary if successful therapies are to be developed. Our objective here was to propose such outcomes. This proposal is the result of 4 face‐to‐face consensus meetings with a 27‐member multidisciplinary team of pediatric rheumatologists, adult rheumatologists, dermatologists, pediatric cardiologists, pulmonologists, gastroenterologists, a statistician, and patients. Throughout the process, we reviewed the existing adult data in this field, the more limited pediatric literature for juvenile SSc outcomes, and data from 2 juvenile SSc patient cohorts to assist in making informed, data‐driven decisions. The use of items for each domain as an outcome measure in an open label 12‐month clinical trial of juvenile SSc was voted and agreed upon using a nominal group technique. After voting, the domains agreed on were global disease activity, skin, Raynaud's phenomenon, digital ulcers, musculoskeletal, cardiac, pulmonary, renal, and gastrointestinal involvement, and quality of life. Fourteen outcome measures had 100% agreement, 1 item had 91% agreement, and 1 item had 86% agreement. The domains of biomarkers and growth/development were moved to the research agenda. We reached consensus on multiple domains and items that should be assessed in an open label, 12‐month clinical juvenile SSc trial as well as a research agenda for future development.

Published
2023
Full Text
View/download PDF

19. Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force

Author

Smith, Eve Mary Dorothy, primary, Aggarwal, Amita, additional, Ainsworth, Jenny, additional, Al-Abadi, Eslam, additional, Avcin, Tadej, additional, Bortey, Lynette, additional, Burnham, Jon, additional, Ciurtin, Coziana, additional, Hedrich, Christian M, additional, Kamphuis, Sylvia, additional, Levy, Deborah M, additional, Lewandowski, Laura B, additional, Maxwell, Naomi, additional, Morand, Eric F, additional, Ozen, Seza, additional, Pain, Clare E, additional, Ravelli, Angelo, additional, Saad Magalhaes, Claudia, additional, Pilkington, Clarissa A, additional, Schonenberg-Meinema, Dieneke, additional, Scott, Christiaan, additional, Tullus, Kjell, additional, and Beresford, Michael William, additional

Published
2023
Full Text
View/download PDF

26. Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research

Author

McCann, Liza J, Pilkington, Clarissa A, Huber, Adam M, Ravelli, Angelo, Appelbe, Duncan, Kirkham, Jamie J, Williamson, Paula R, Aggarwal, Amita, Christopher-Stine, Lisa, Constantin, Tamas, Feldman, Brian M, Lundberg, Ingrid, Maillard, Sue, Mathiesen, Pernille, Murphy, Ruth, Pachman, Lauren M, Reed, Ann M, Rider, Lisa G, van Royen-Kerkof, Annet, Russo, Ricardo, Spinty, Stefan, Wedderburn, Lucy R, and Beresford, Michael W

Published
2018
Full Text
View/download PDF

27. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups

Author

Lundberg, Ingrid E, Tjärnlund, Anna, Bottai, Matteo, Werth, Victoria P, Pilkington, Clarissa, Visser, Marianne de, Alfredsson, Lars, Amato, Anthony A, Barohn, Richard J, Liang, Matthew H, Singh, Jasvinder A, Aggarwal, Rohit, Arnardottir, Snjolaug, Chinoy, Hector, Cooper, Robert G, Dankó, Katalin, Dimachkie, Mazen M, Feldman, Brian M, Torre, Ignacio Garcia-De La, Gordon, Patrick, Hayashi, Taichi, Katz, James D, Kohsaka, Hitoshi, Lachenbruch, Peter A, Lang, Bianca A, Li, Yuhui, Oddis, Chester V, Olesinska, Marzena, Reed, Ann M, Rutkowska-Sak, Lidia, Sanner, Helga, Selva-O’Callaghan, Albert, Song, Yeong-Wook, Vencovsky, Jiri, Ytterberg, Steven R, Miller, Frederick W, and Rider, Lisa G

Published
2017
Full Text
View/download PDF

28. European evidence-based recommendations for the diagnosis and treatment of childhood-onset lupus nephritis: the SHARE initiative

Author

Groot, Noortje, de Graeff, Nienke, Marks, Stephen D, Brogan, Paul, Avcin, Tadej, Bader-Meunier, Brigitte, Dolezalova, Pavla, Feldman, Brian M, Kone-Paut, Isabelle, Lahdenne, Pekka, McCann, Liza, Özen, Seza, Pilkington, Clarissa A, Ravelli, Angelo, Royen-Kerkhof, Annet van, Uziel, Yosef, Vastert, Bas J, Wulffraat, Nico M, Beresford, Michael W, and Kamphuis, Sylvia

Published
2017
Full Text
View/download PDF

29. Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to- consider from an international task force.

Author

Dorothy Smith, Eve Mary, Aggarwal, Amita, Ainsworth, Jenny, Al-Abadi, Eslam, Avcin, Tadej, Bortey, Lynette, Burnham, Jon, Ciurtin, Coziana, Hedrich, Christian M., Kamphuis, Sylvia, Levy, Deborah M., Lewandowski, Laura B., Maxwell, Naomi, Morand, Eric F., Ozen, Seza, Pain, Clare E., Ravelli, Angelo, Magalhaes, Claudia Saad, Pilkington, Clarissa A., and Schonenberg-Meinema, Dieneke

Published
2023
Full Text
View/download PDF

31. European evidence-based recommendations for diagnosis and treatment of childhood-onset systemic lupus erythematosus: the SHARE initiative

Author

Groot, Noortje, de Graeff, Nienke, Avcin, Tadej, Bader-Meunier, Brigitte, Brogan, Paul, Dolezalova, Pavla, Feldman, Brian, Kone-Paut, Isabelle, Lahdenne, Pekka, Marks, Stephen D, McCann, Liza, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Royen-Kerkhof, Annet van, Uziel, Yosef, Vastert, Bas, Wulffraat, Nico, Kamphuis, Sylvia, and Beresford, Michael W

Published
2017
Full Text
View/download PDF

32. 2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria—methodological aspects

Author

Rider, Lisa G, Ruperto, Nicolino, Pistorio, Angela, Erman, Brian, Bayat, Nastaran, Lachenbruch, Peter A, Rockette, Howard, Feldman, Brian M, Huber, Adam M, Hansen, Paul, Oddis, Chester V, Lundberg, Ingrid E, Amato, Anthony A, Chinoy, Hector, Cooper, Robert G, Chung, Lorinda, Danko, Katalin, Fiorentino, David, García-De la Torre, Ignacio, Reed, Ann M, Wook Song, Yeong, Cimaz, Rolando, Cuttica, Rubén J, Pilkington, Clarissa A, Martini, Alberto, van der Net, Janjaap, Maillard, Susan, Miller, Frederick W, Vencovsky, Jiri, and Aggarwal, Rohit

Published
2017
Full Text
View/download PDF

33. European evidence-based recommendations for diagnosis and treatment of paediatric antiphospholipid syndrome: the SHARE initiative

Author

Groot, Noortje, de Graeff, Nienke, Avcin, Tadej, Bader-Meunier, Brigitte, Dolezalova, Pavla, Feldman, Brian, Kenet, Gili, Koné-Paut, Isabelle, Lahdenne, Pekka, Marks, Stephen D, McCann, Liza, Pilkington, Clarissa A, Ravelli, Angelo, van Royen-Kerkhof, Annet, Uziel, Yosef, Vastert, Sebastiaan J, Wulffraat, Nico M, Ozen, Seza, Brogan, Paul, Kamphuis, Sylvia, and Beresford, Michael W

Published
2017
Full Text
View/download PDF

34. Consensus-based recommendations for the management of juvenile dermatomyositis

Author

Enders, Felicitas Bellutti, Bader-Meunier, Brigitte, Baildam, Eileen, Constantin, Tamas, Dolezalova, Pavla, Feldman, Brian M, Lahdenne, Pekka, Magnusson, Bo, Nistala, Kiran, Ozen, Seza, Pilkington, Clarissa, Ravelli, Angelo, Russo, Ricardo, Uziel, Yosef, van Brussel, Marco, van der Net, Janjaap, Vastert, Sebastiaan, Wedderburn, Lucy R, Wulffraat, Nicolaas, McCann, Liza J, and van Royen-Kerkhof, Annet

Published
2017
Full Text
View/download PDF

35. The vascular phenotype of children with systemic lupus erythematosus

Author

Quinlan, Catherine, Kari, Jameela, Pilkington, Clarissa, Deanfield, John, Shroff, Rukshana, Marks, Stephen D., and Tullus, Kjell

Subjects
Systemic lupus erythematosus -- Research -- Development and progression -- Care and treatment -- Patient outcomes -- Complications and side effects, Cardiovascular diseases -- Research -- Development and progression -- Care and treatment, Health
Abstract

Background The increased risk of cardiovascular disease (CVD) in adults with systemic lupus erythematosus (SLE) has been known since the 1970s, but studies in juvenile-onset SLE (JSLE) have reported conflicting results and more data are needed. The aim of this cross-sectional study was to establish the baseline risk of CVD in a cohort of UK patients with JSLE. Methods Data were collected to establish disease duration, disease activity, medication use and activity levels, as well as demographic data, including family history of CVD. Vascular phenotype was established using well-validated measures of carotid intima media thickness (cIMT) and pulse wave velocity (PWV). Results In total, 45 children (39 female; mean age 13.5 ± 2.9 years) with JSLE were recruited to the study. Of these, 24 had a history of biopsy-proven lupus nephritis and five had an estimated glomerular filtration rate of Conclusion This study shows that our patients with JSLE had increased cIMT without an increase in PWV, suggesting possible early adaptive changes in JSLE. Follow-up data are needed to determine whether these changes result in clinically significant CVD. Electronic supplementary material The online version of this article (doi:10.1007/s00467-015-3059-9) contains supplementary material, which is available to authorized users., Author(s): Catherine Quinlan[sup.1] , Jameela Kari[sup.2] , Clarissa Pilkington[sup.3] , John Deanfield[sup.4] , Rukshana Shroff[sup.3] , Stephen D. Marks[sup.3] , Kjell Tullus[sup.3] Author Affiliations: (1) Department of Nephrology, The Royal [...]

Published
2015
Full Text
View/download PDF

36. American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

Author

Brunner, Hermine I, Holland, Michael J, Beresford, Michael W, Ardoin, Stacy P, Appenzeller, Simone, Silva, Clovis A, Flores, Francisco, Goilav, Beatrice, Aydin, Pinar Ozge Avar, Wenderfer, Scott E, Levy, Deborah M, Ravelli, Angelo, Khubchandani, Raju, Avcin, Tadej, Klein-Gitelman, Marisa S, Ruperto, Nicolino, Feldman, Brian M, Ying, Jun, Battagliotti, Cristina, Brusco, Maria Isabel, Cuttica, Ruben, De Cunto, Carmen, Espada, Graciela, Farfan, Maximiliano, Garay, Stella, Marcantoni, Maria, Marcela, Alvarez, Meiorin, Silvia, Rama, Maria Elena, Russo, Ricardo, Walsh, Carolina Torre, Zamparo, Celso, Adib, Navid, Akikusa, Jonathan, Boros, Christina, Lee, Senq J, Mckay, Damien, Piper, Susan, Joos, Rik, Bica, Blanca, Campos, Leonardo, Cavalcanti, Andre, do Prado, Rogerio, Donner-Maliki, Amanda, Fernandes, Taciana, Fonseca, Adriana, de Almeida, Rozana Gasparello, Guariento, Andressa, Gusman, Catherine, Fiorot, Fernanda Jusan, Oliveira, Sheila Knupp, Len, Claudio, Campos, Lucia M Arruda, Machado, Sandra, Marques, Luciana, de Carvalho, Luciana Martins, Moulin, Rodrigo, Pedroso, Soraya, Pileggi, Gecilmara, Romanelli, Paulo Roberto S, Saad-Magalhaes, Claudia, Sakamoto, Ana, Santos, Maria Carolina, Silva, Marco Felipe, Spelling, Paulo, Sztajnbok, Flavio, Terreri, Maria, Cabral, David, Chedeville, Gaelle, Ellsworth, Janet, Huber, Adam, Tucker, Lori, Houghton, Kristin, Borzutzky, Arturo, Ladino, Mabel, Norambuena, Ximena, Eraso, Ruth, Mosquera, Angela, Velasquez, Monica, Harjacek, Miroslav, Jelusic, Marija, Hermosilla, Cecilia Coto, Dolezalova, Pavla, Nielsen, Susan, Tineo, Carmen, Alegria, Mauricio, Dressler, Frank, Foell, Dirk, Ganser, Gerd, Hinze, Claas, Hufnagel, Markus, Lutz, Thomas, Trauzeddel, Ralf, Boiu, Sorina, Trachana, Maria, Tsitsami, Elena, Cifuentes, Mayra, Orban, Ilonka, Aggarwal, Amita, Sawhney, Sujata, Aviel, Yonatan Butbul, Cimaz, Rolando, Maggio, Maria Cristina, Rumba-Rozenfelde, Ingrid, Hashad, Soad, Lim, Sern Chin, Abud, Carlos, Burgos-Vargas, Ruben, Carreno-Manjarrez, Roberto, Enciso Pelaez, Sandra, Hernandez-Huirache, Hayde, Maldonado Velazquez, Rocio, Orozco, Javier, Rodriguez-Lozano, Ana Luisa, Rojas Pacheco, Omar Ernesto, Suarez Larios, Luz Maria, Vega, Gabriel, Ramirez Miramontes, Julia Veronica, Ruiz Lopez, Ivon Karina, Kamphuis, Sylvia, Schonenberg-Meinema, Dieneke, Concannon, Anthony, Yan, Jaqueline, Jaime, Martha Jarquin, Al Abrawi, Safiya, Vega, Cynthia, Lopez-Benitez, Jorge, Estrella, Amparo Ibanez, Miraval, Tatiana, Dans, Leonia, Kimseng, Karen Joy, Opoka-Winiarska, Violetta, Rutkowska-Sak, Lidia, Smolewska, Elzbieta, Conde, Marta, Guedes, Margarida, del Valle, Enid, Quintero-Del Rio, Ana, Ailioaie, Constantin, Sparchez, Mihaela, Alekseeva, Ekaterina, Keltsev, Vladimir, Al-Mayouf, Sulaiman, Asiri, Abdurhman, Suwairi, Wafaa, Susic, Gordana, Vijatov-Djuric, Gordana, Ang, Elizabeth, Arkachaisri, Thaschawee, Boteanu, Alina-Lucica, Lopez-Robledillo, Juan Carlos, San Ildefonso, Marta Medrano, Modesto, Consuelo, Calvo, Inmaculada, Sotoca-Fernandez, Jorge, Bolt, Isabel, Vilaiyuk, Soamarat, Al-Abadi, Eslam, Baildam, Eileen, Fotis, Lampros, Pain, Clare, Pilkington, Clarissa, Abulaban, Khalid, Barbar-Smiley, Fatima, Binstadt, Bryce, Bohnsack, John, Boneparth, Alexis, Brown, Diane, Chira, Peter, Cron, Randy, Dedeoglu, Fatma, Eberhard, Anne, Gedalia, Abraham, Grom, Alexei, Henrickson, Michael, Hom, Christine, Huggins, Jennifer, Jerath, Rita, Jones, Jordan, Jung, Lawrence, Kingsbury, Daniel, Lai, Jamie, Lovell, Daniel, Nanda, Kabita, Nocton, James, Olson, Judyann, O'Neil, Kathleen, Onel, Karen, Punaro, Lynn, Reiff, Andreas, Rouster-Stevens, Kelly, Ruth, Natasha, Schikler, Ken, Schmidt, Kara Murphy, Schulert, Grant, Shaham, Bracha, Singer, Nora, Smith, Judith, Sundel, Robert, Syverson, Grant, Vega-Fernandez, Patricia, Vehe, Richard, Wagner-Weiner, Linda, Cameto, Juan, Jurado, Rosario, Maldonado, Irama, Org, Paediat Rheumatology Int Trial, Collaborative, Pediat Rheumatology, AII - Inflammatory diseases, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, Brunner, Hermine I., Holland, Michael J., Beresford, Michael W., Ardoin, Stacy P., Appenzeller, Simone, Silva, Clovis A., Flores, Francisco, Goilav, Beatrice, Avar Aydin, Pinar Ozge, Wenderfer, Scott E., Levy, Deborah M., Ravelli, Angelo, Khubchandani, Raju, Avcin, Tadej, Klein-Gitelman, Marisa S., Ruperto, Nicolino, Feldman, Brian M., Ying, Jun, Battagliotti, Cristina, Brusco, Maria Isabel, Cuttica, Rubén, De Cunto, Carmen, Espada, Graciela, Farfan, Maximiliano, Garay, Stella, Marcantoni, Maria, Marcela, Alvarez, Meiorin, Silvia, Rama, Maria Elena, Russo, Ricardo, Torre Walsh, Carolina, Zamparo, Celso, Adib, Navid, Akikusa, Jonathan, Boros, Christina, Lee, Senq J., Mckay, Damien, Piper, Susan, Joos, Rik, Bica, Blanca, Campos, Leonardo, Cavalcanti, André, do Prado, Rogerio, Donner-Maliki, Amanda, Fernandes, Taciana, Fonseca, Adriana, Gasparello de Almeida, Rozana, Guariento, Andressa, Gusman, Catherine, Jusan Fiorot, Fernanda, Knupp Oliveira, Sheila, Len, Claudio, Arruda Campos, Lucia M., Machado, Sandra, Marques, Luciana, Martins de Carvalho, Luciana, Moulin, Rodrigo, Pedroso, Soraya, Pileggi, Gecilmara, Romanelli, Paulo Roberto S., Saad-Magalhaes, Claudia, Sakamoto, Ana, Santos, Maria Carolina, Silva, Marco Felipe, Spelling, Paulo, Sztajnbok, Slavio, Terreri, Maria, Cabral, David, Chédeville, Gaëlle, Ellsworth, Janet, Huber, Adam, Tucker, Lori, Houghton, Kristin, Borzutzky, Arturo, Ladino, Mabel, Norambuena, Ximena, Eraso, Ruth, Mosquera, Angela, Velasquez, Monica, Harjacek, Miroslav, Jelusic, Marija, Coto Hermosilla, Cecilia, Dolezalova, Pavla, Nielsen, Susan, Tineo, Carmen, Alegria, Mauricio, Dressler, Frank, Foell, Dirk, Ganser, Gerd, Hinze, Claa, Hufnagel, Marku, Lutz, Thoma, Trauzeddel, Ralf, Boiu, Sorina, Trachana, Maria, Tsitsami, Elena, Cifuentes, Mayra, Orbán, Ilonka, Aggarwal, Amita, Sawhney, Sujata, Butbul Aviel, Yonatan, Cimaz, Rolando, Maggio, Maria Cristina, Rumba-Rozenfelde, Ingrid, Hashad, Soad, Lim, Sern Chin, Abud, Carlo, Burgos-Vargas, Ruben, Carreño-Manjarrez, Roberto, Enciso Pelaez, Sandra, Hernandez-Huirache, Hayde, Maldonado Velázquez, Rocio, Orozco, Javier, Rodriguez-Lozano, Ana Luisa, Rojas Pacheco, Omar Ernesto, Suárez Larios, Luz Maria, Vega, Gabriel, Ramírez Miramontes, Julia Verónica, Ruíz Lopez, Ivon Karina, Kamphuis, Sylvia, Schonenberg-Meinema, Dieneke, Concannon, Anthony, Yan, Jaqueline, Jarquin Jaime, Martha, Al Abrawi, Safiya, Vega, Cynthia, Lopez-Benitez, Jorge, Ibáñez Estrella, Amparo, Miraval, Tatiana, Dans, Leonia, Kimseng, Karen Joy, Opoka-Winiarska, Violetta, Rutkowska-Sak, Lidia, Smolewska, Elzbieta, Conde, Marta, Guedes, Margarida, del Valle, Enid, Quintero-Del Rio, Ana, Ailioaie, Constantin, Sparchez, Mihaela, Alekseeva, Ekaterina, Keltsev, Vladimir, Al-Mayouf, Sulaiman, Asiri, Abdurhman, Suwairi, Wafaa, Susic, Gordana, Vijatov-Djuric, Gordana, Ang, Elizabeth, Arkachaisri, Thaschawee, Boteanu, Alina-Lucica, Lopez-Robledillo, Juan Carlo, Medrano San Ildefonso, Marta, Modesto, Consuelo, Calvo, Inmaculada, Sotoca-Fernandez, Jorge, Bolt, Isabel, Vilaiyuk, Soamarat, Al-Abadi, Eslam, Baildam, Eileen, Fotis, Lampro, Pain, Clare, Pilkington, Clarissa, Abulaban, Khalid, Barbar-Smiley, Fatima, Binstadt, Bryce, Bohnsack, John, Boneparth, Alexi, Brown, Diane, Chira, Peter, Cron, Randy, Dedeoglu, Fatma, Eberhard, Anne, Gedalia, Abraham, Grom, Alexei, Henrickson, Michael, Hom, Christine, Huggins, Jennifer, Jerath, Rita, Jones, Jordan, Jung, Lawrence, Kingsbury, Daniel, Lai, Jamie, Lovell, Daniel, Nanda, Kabita, Nocton, Jame, Olson, Judyann, O’Neil, Kathleen, Onel, Karen, Punaro, Lynn, Reiff, Andrea, Rouster-Stevens, Kelly, Ruth, Natasha, Schikler, Ken, Murphy Schmidt, Kara, Schulert, Grant, Shaham, Bracha, Singer, Nora, Smith, Judith, Sundel, Robert, Syverson, Grant, Vega-Fernandez, Patricia, Vehe, Richard, Wagner-Weiner, Linda, Cameto, Juan, Jurado, Rosario, Maldonado, Irama, and Pediatrics

Subjects
medicine.medical_specialty, Outcome Assessment, Health Care/methods, Adolescent, Delphi Technique, Antirheumatic Agents/therapeutic use, Severity of Illness Index, Child health, Article, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Internal medicine, Severity of illness, Outcome Assessment, Health Care, medicine, Pediatric nephrology, Humans, Lupus Erythematosus, Systemic, skin and connective tissue diseases, Child, 030203 arthritis & rheumatology, Systemic lupus erythematosus, Lupus erythematosus, Lupus Erythematosus, Receiver operating characteristic, business.industry, Consensus conference, childhood-onset systemic lupus erythematosus, Outcome Assessment, Health Care/methods, medicine.disease, Rheumatology,Systemic lupus erythematosus,autoimmune inflammatory disease, Antirheumatic Agents, Lupus Erythematosus, Systemic/drug therapy, Systemic/drug therapy, business, Algorithms
Abstract

OBJECTIVE: To develop a Childhood Lupus Improvement Index (CHILI) as a tool to measure response to therapy in childhood-onset systemic lupus erythematosus (cSLE), with a focus on clinically relevant improvement (CRIc SLE ). METHODS: Pediatric nephrology and rheumatology subspecialists (n = 213) experienced in cSLE management were invited to define CRIc SLE and rate a total of 433 unique patient profiles for the presence/absence of CRIc SLE . Patient profiles included the following cSLE core response variables (CRVs): global assessment of patient well-being (patient-global), physician assessment of cSLE activity (MD-global), disease activity index score (here, we used the Systemic Lupus Erythematosus Disease Activity Index), urine protein-to-creatinine ratio, and Child Health Questionnaire physical summary score. Percentage and absolute changes in these cSLE- CRVs (baseline versus follow-up) were considered in order to develop candidate algorithms and validate their performance (sensitivity, specificity, area under the receiver operating characteristic curve [AUC] ; range 0-1). RESULTS: During an international consensus conference, unanimous agreement on a definition of CRIc SLE was achieved ; cSLE experts (n = 13) concurred (100%) that the preferred CHILI algorithm considers absolute changes in the cSLE- CRVs. After transformation to a range of 0-100, a CHILI score of ≥54 had outstanding accuracy for identifying CRIc SLE (AUC 0.93, sensitivity 81.1%, and specificity 84.2%). CHILI scores also reflect minor, moderate, and major improvement for values exceeding 15, 68, and 92, respectively (all AUC ≥0.92, sensitivity ≥93.1%, and specificity ≥73.4%). CONCLUSION: The CHILI is a new, seemingly highly accurate index for measuring CRI in cSLE over time. This index is useful to categorize the degree of response to therapy in children and adolescents with cSLE.

Published
2019

37. Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE

Author

Charras, Amandine, primary, Haldenby, Sam, additional, Smith, Eve M D, additional, Egbivwie, Naomi, additional, Olohan, Lisa, additional, Kenny, John G, additional, Schwarz, Klaus, additional, Roberts, Carla, additional, Al-Abadi, Eslam, additional, Armon, Kate, additional, Bailey, Kathryn, additional, Ciurtin, Coziana, additional, Gardner-Medwin, Janet, additional, Haslam, Kirsty, additional, Hawley, Daniel P, additional, Leahy, Alice, additional, Leone, Valentina, additional, McErlane, Flora, additional, Modgil, Gita, additional, Pilkington, Clarissa, additional, Ramanan, Athimalaipet V, additional, Rangaraj, Satyapal, additional, Riley, Phil, additional, Sridhar, Arani, additional, Beresford, Michael W, additional, and Hedrich, Christian M, additional

Published
2022
Full Text
View/download PDF

40. Validation of a score tool for measurement of histological severity in juvenile dermatomyositis and association with clinical severity of disease

Author

Varsani, Hemlata, Charman, Susan C, Li, Charles K, Marie, Suely K N, Amato, Anthony A, Banwell, Brenda, Bove, Kevin E, Corse, Andrea M, Emslie-Smith, Alison M, Jacques, Thomas S, Lundberg, Ingrid E, Minetti, Carlo, Nennesmo, Inger, Rushing, Elisabeth J, Sallum, Adriana M E, Sewry, Caroline, Pilkington, Clarissa A, Holton, Janice L, Wedderburn, Lucy R, McCann, Liza, Roberts, Ian, Baildam, Eileen, Hanna, Louise, Lloyd, Olivia, Riley, Phil, McGovern, Ann, Ryder, Clive, Scott, Janis, Wyatt, Sue, Jackson, Gillian, Amin, Tania, Wood, Mark, VanRooyen, Vanessa, Davidson, Joyce, Gardner-Medwin, Janet, Martin, Neil, Ferguson, Sue, Waxman, Liz, Friswell, Mark, Foster, Helen, Swift, Alison, Jandial, Sharmila, Stevenson, Vicky, Wade, Debbie, Sen, Ethan, Smith, Eve, Qiao, Lisa, Venning, Helen, Satyapal, Rangaraj, Stretton, Elizabeth, Jordan, Mary, Armon, Kate, Ellis-Gage, Joe, Roper, Holly, Wedderburn, Lucy, Pilkington, Clarissa, Hasson, N, Maillard, Sue, Halkon, Elizabeth, Brown, Virginia, Juggins, Audrey, Smith, Sally, Lunt, Sian, Enayat, Elli, Beard, Laura, Kassoumeri, Laura, Arnold, Katie, Murray, Kevin, Ioannou, John, and Suffiel, Linda

Published
2015
Full Text
View/download PDF

41. Attainment of low disease activity and remission targets reduces the risk of severe flare and new damage in childhood lupus

Author

Smith, Eve M D, primary, Tharmaratnam, Kukatharmini, additional, Al-Abadi, Eslam, additional, Armon, Kate, additional, Bailey, Kathryn, additional, Brennan, Mary, additional, Ciurtin, Coziana, additional, Gardner-Medwin, Janet, additional, Haslam, Kirsty E, additional, Hawley, Daniel, additional, Leahy, Alice, additional, Leone, Valentina, additional, Malik, Gulshan, additional, McLaren, Zoe, additional, Pilkington, Clarissa, additional, Ramanan, Athimalaipet V, additional, Rangaraj, Satyapal, additional, Ratcliffe, Annie, additional, Riley, Philip, additional, Sen, Ethan, additional, Sridhar, Arani, additional, Wilkinson, Nick, additional, Hedrich, Christian M, additional, Jorgensen, Andrea, additional, and Beresford, Michael W, additional

Published
2021
Full Text
View/download PDF

42. Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study

Author

Giani, Teresa, Smith, Eve MD, Al-Abadi, Eslam, Armon, Kate, Bailey, Kathryn, Ciurtin, Coziana, Davidson, Joyce, Gardner-Medwin, Janet, Haslam, Kirsty, Hawley, Dan P, Leahy, Alice, Leone, Valentina, McErlane, Flora, Mewar, Devesh, Modgil, Gita, Moots, Robert, Pilkington, Clarissa, Pregnolato, Francesca, Ramanan, Athimalaipet V, Rangaraj, Satyapal, Riley, Phil, Sridhar, Arani, Wilkinson, Nick, Cimaz, Rolando, Beresford, Michael W, Hedrich, Christian M, and Study, On Behalf Of The UK JSLE Cohort

Subjects
Systemic lupus erythematosus, pediatric, juvenile, peripheral nervous system, neuropsychiatric, Papers, central nervous system
Abstract

Funder: Versus Arthritis UK, Funder: LUPUS UK; FundRef: https://doi.org/10.13039/501100018817, Introduction: Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement is a severe complication, encompassing a heterogeneous range of neurological and psychiatric manifestations. Methods: Demographic, clinical, and laboratory features of NP-SLE were assessed in participants of the UK JSLE Cohort Study, and compared to patients in the same cohort without NP manifestations. Results: A total of 428 JSLE patients were included in this study, 25% of which exhibited NP features, half of them at first visit. Most common neurological symptoms among NP-JSLE patients included headaches (78.5%), mood disorders (48.6%), cognitive impairment (42%), anxiety (23.3%), seizures (19.6%), movement disorders (17.7%), and cerebrovascular disease (14.9%). Peripheral nervous system involvement was recorded in 7% of NP-SLE patients. NP-JSLE patients more frequently exhibited thrombocytopenia (

Published
2021
Full Text
View/download PDF

43. Whole-genome sequencing of patients with rare diseases in a national health system

Author

Turro, Ernest, Astle, William J., Megy, Karyn, Gräf, Stefan, Greene, Daniel, Shamardina, Olga, Allen, Hana Lango, Sanchis-Juan, Alba, Frontini, Mattia, Thys, Chantal, Stephens, Jonathan, Mapeta, Rutendo, Burren, Oliver S., Downes, Kate, Haimel, Matthias, Tuna, Salih, Deevi, Sri V.V., Aitman, Timothy J., Bennett, David L., Calleja, Paul, Carss, Keren, Caulfield, Mark J., Chinnery, Patrick F., Dixon, Peter H., Gale, Daniel P., James, Roger, Koziell, Ania, Laffan, Michael A., Levine, Adam P., Maher, Eamonn R., Markus, Hugh S., Morales, Joannella, Morrell, Nicholas W., Mumford, Andrew D., Ormondroyd, Elizabeth, Rankin, Stuart, Rendon, Augusto, Richardson, Sylvia, Roberts, Irene, Roy, Noemi B.A., Saleem, Moin A., Smith, Kenneth G.C., Stark, Hannah, Tan, Rhea Y.Y., Themistocleous, Andreas C., Thrasher, Adrian J., Watkins, Hugh, Webster, Andrew R., Wilkins, Martin R., Williamson, Catherine, Whitworth, James, Humphray, Sean, Bentley, David R., Abbs, Stephen, Abulhoul, Lara, Adlard, Julian, Ahmed, Munaza, Alachkar, Hana, Allsup, David J., Almeida-King, Jeff, Ancliff, Philip, Antrobus, Richard, Armstrong, Ruth, Arno, Gavin, Ashford, Sofie, Attwood, Anthony, Aurora, Paul, Babbs, Christian, Bacchelli, Chiara, Bakchoul, Tamam, Banka, Siddharth, Bariana, Tadbir, Barwell, Julian, Batista, Joana, Baxendale, Helen E., Beales, Phil L., Bierzynska, Agnieszka, Biss, Tina, Bitner-Glindzicz, Maria A.K., Black, Graeme C., Bleda, Marta, Blesneac, Iulia, Bockenhauer, Detlef, Bogaard, Harm, Bourne, Christian J., Boyce, Sara, Bradley, John R., Bragin, Eugene, Breen, Gerome, Brennan, Paul, Brewer, Carole, Brown, Matthew, Browning, Andrew C., Browning, Michael J., Buchan, Rachel J., Buckland, Matthew S., Bueser, Teofila, Diz, Carmen Bugarin, Burn, John, Burns, Siobhan O., Burrows, Nigel, Campbell, Carolyn, Carr-White, Gerald, Casey, Ruth, Chambers, Jenny, Chambers, John, Chan, Melanie M.Y., Cheah, Calvin, Cheng, Floria, Chitre, Manali, Christian, Martin T., Church, Colin, Clayton-Smith, Jill, Cleary, Maureen, Brod, Naomi Clements, Coghlan, Gerry, Colby, Elizabeth, Cole, Trevor R.P., Collins, Janine, Collins, Peter W., Colombo, Camilla, Compton, Cecilia J., Condliffe, Robin, Cook, Stuart, Cook, H. Terence, Cooper, Nichola, Corris, Paul A A., Furnell, Abigail, Cunningham, Fiona, Curry, Nicola S., Cutler, Antony J., Daniels, Matthew J., Dattani, Mehul, Daugherty, Louise C., Davis, John, De Soyza, Anthony, Dent, Timothy, Deshpande, Charu, Dewhurst, Eleanor F., Douzgou, Sofia, Drazyk, Anna M., Drewe, Elizabeth, Duarte, Daniel, Dutt, Tina, Edgar, J. David M., Edwards, Karen, Egner, William, Ekani, Melanie N., Elliott, Perry, Erber, Wendy N., Erwood, Marie, Estiu, Maria C., Evans, Dafydd Gareth, Evans, Gillian, Everington, Tamara, Eyries, Mélanie, Fassihi, Hiva, Favier, Remi, Findhammer, Jack, Fletcher, Debra, Flinter, Frances A., Floto, R. Andres, Fowler, Tom, Fox, James, Frary, Amy J., French, Courtney E., Freson, Kathleen, Gall, Henning, Ganesan, Vijeya, Gattens, Michael, Geoghegan, Claire, Gerighty, Terence S.A., Gharavi, Ali G., Ghio, Stefano, Ghofrani, Hossein Ardeschir, Gibbs, J. Simon R., Gibson, Kate, Gilmour, Kimberly C., Girerd, Barbara, Gleadall, Nicholas S., Goddard, Sarah, Goldstein, David B., Gomez, Keith, Gordins, Pavels, Gosal, David, Graham, Jodie, Grassi, Luigi, Greenhalgh, Lynn, Greinacher, Andreas, Gresele, Paolo, Griffiths, Philip, Grigoriadou, Sofia, Grocock, Russell J., Grozeva, Detelina, Gurnell, Mark, Hackett, Scott, Hadinnapola, Charaka, Hague, William M., Hague, Rosie, Hall, Matthew, Hanson, Helen L., Haque, Eshika, Harkness, Kirsty, Harper, Andrew R., Harris, Claire L L., Hart, Daniel, Hassan, Ahamad, Hayman, Grant, Henderson, Alex, Herwadkar, Archana, Hoffman, Jonathan, Holden, Simon, Horvath, Rita, Houlden, Henry, Houweling, Arjan C C., Howard, Luke S., Hu, Fengyuan, Hudson, Gavin, Hughes, Joseph, Huissoon, Aarnoud P., Humbert, Marc, Hunter, Sarah, Hurles, Matthew, Irving, Melita, Izatt, Louise, Johnson, Sally A., Jolles, Stephen, Jolley, Jennifer, Josifova, Dragana, Jurkute, Neringa, Karten, Tim, Karten, Johannes, Kasanicki, Mary A., Kazkaz, Hanadi, Kazmi, Rashid, Kelleher, Peter, Kelly, Anne M., Kelsall, Wilf, Kempster, Carly, Kiely, David G., Kingston, Nathalie, Klima, Robert, Koelling, Nils, Kostadima, Myrto, Kovacs, Gabor, Kreuzhuber, Roman, Kuijpers, Taco W., Kumar, Ajith, Kumararatne, Dinakantha, Kurian, Manju A., Lalloo, Fiona, Lambert, Michele, Lawrie, Allan, Layton, D. Mark, Lench, Nick, Lentaigne, Claire, Lester, Tracy, Linger, Rachel, Longhurst, Hilary, Lorenzo, Lorena E., Louka, Eleni, Lyons, Paul A., Machado, Rajiv D., MacKenzie Ross, Robert V., Madan, Bella, Maimaris, Jesmeen, Malka, Samantha, Mangles, Sarah, Marchbank, Kevin J., Marks, Stephen, Marschall, Hanns Ulrich, Marshall, Andrew, Martin, Jennifer, Mathias, Mary, Matthews, Emma, Maxwell, Heather, McAlinden, Paul, McCarthy, Mark I., McKinney, Harriet, McMahon, Aoife, Meacham, Stuart, Mead, Adam J., Castello, Ignacio Medina, Mehta, Sarju G G., Michaelides, Michel, Millar, Carolyn, Mohammed, Shehla N., Moledina, Shahin, Montani, David, Moore, Anthony T., Mozere, Monika, Muir, Keith W., Nemeth, Andrea H., Newman, William G., Newnham, Michael, Noorani, Sadia, Nurden, Paquita, O’Sullivan, Jennifer, Obaji, Samya, Odhams, Chris, Okoli, Steven, Olschewski, Andrea, Olschewski, Horst, Ong, Kai Ren, Oram, S. Helen, Ouwehand, Willem H., Palles, Claire, Papadia, Sofia, Park, Soo Mi, Parry, David, Patel, Smita, Paterson, Joan, Peacock, Andrew, Pearce, Simon H H., Peden, John, Peerlinck, Kathelijne, Penkett, Christopher J., Pepke-Zaba, Joanna, Petersen, Romina, Pilkington, Clarissa, Poole, Kenneth E.S., Prathalingam, Radhika, Psaila, Bethan, Pyle, Angela, Quinton, Richard, Rahman, Shamima, Rao, Anupama, Raymond, F. Lucy, Rayner-Matthews, Paula J., Rees, Christine, Renton, Tara, Rhodes, Christopher J., Rice, Andrew S.C., Richter, Alex, Robert, Leema, Rogers, Anthony, Rose, Sarah J., Ross-Russell, Robert, Roughley, Catherine, Roy, Noemi B. A, Ruddy, Deborah M., Sadeghi-Alavijeh, Omid, Samani, Nilesh, Samarghitean, Crina, Sargur, Ravishankar B., Sarkany, Robert N., Satchell, Simon, Savic, Sinisa, Sayer, John A., Sayer, Genevieve, Scelsi, Laura, Schaefer, Andrew M., Schulman, Sol, Scott, Richard, Scully, Marie, Searle, Claire, Seeger, Werner, Sen, Arjune, Sewell, W. A.Carrock, Seyres, Denis, Shah, Neil, Shapiro, Susan E., Shaw, Adam C., Short, Patrick J., Sibson, Keith, Side, Lucy, Simeoni, Ilenia, Simpson, Michael A A., Sims, Matthew C., Sivapalaratnam, Suthesh, Smedley, Damian, Smith, Katherine R., Snape, Katie, Soranzo, Nicole, Soubrier, Florent, Southgate, Laura, Spasic-Boskovic, Olivera, Staines, Simon, Staples, Emily, Steward, Charles, Stirrups, Kathleen E., Stuckey, Alex, Suntharalingam, Jay, Swietlik, Emilia M., Syrris, Petros, Tait, R. Campbell, Talks, Kate, Tate, Katie, Taylor, John M., Taylor, Jenny C., Thaventhiran, James E., Thomas, Ellen, Thomas, David, Thomas, Moira J., Thomas, Patrick, Thomson, Kate, Threadgold, Glen, Tilly, Tobias, Tischkowitz, Marc, Titterton, Catherine, Todd, John A., Toh, Cheng Hock, Tolhuis, Bas, Tomlinson, Ian P., Toshner, Mark, Traylor, Matthew, Treacy, Carmen, Treadaway, Paul, Trembath, Richard, Turek, Wojciech, Twiss, Philip, Vale, Tom, Geet, Chris Van, Zuydam, Natalie van, Vandekuilen, Maarten, Vandersteen, Anthony M., Vazquez-Lopez, Marta, von Ziegenweidt, Julie, Vonk Noordegraaf, Anton, Wagner, Annette, Waisfisz, Quinten, Walker, Suellen M., Walker, Neil, Walter, Klaudia, Ware, James S., Watt, Christopher, Wedderburn, Lucy, Wei, Wei, Welch, Steven B., Wessels, Julie, Westbury, Sarah K., Westwood, John Paul, Wharton, John, Whitehorn, Deborah, Wilkie, Andrew O. M, Wilson, Brian T., Wong, Edwin K.S., Wood, Nicholas, Wood, Yvette, Woods, Christopher Geoffrey, Woodward, Emma R R., Wort, Stephen J., Worth, Austen, Wright, Michael, Yates, Katherine, Yong, Patrick F.K., Young, Timothy, Yu, Ping, Yu-Wai-Man, Patrick, Zlamalova, Eliska, University of Cambridge [UK] (CAM), John Wyeth & Brother Limited, Medical Research Council (MRC), Wellcome Trust, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Human genetics, ACS - Atherosclerosis & ischemic syndromes, Landsteiner Laboratory, Paediatric Infectious Diseases / Rheumatology / Immunology, ARD - Amsterdam Reproduction and Development, and Project, NIHR BioResource for the 100,000 Genomes

Subjects
0301 basic medicine, Erythrocytes, Internationality, Databases, Factual, National Health Programs, [SDV]Life Sciences [q-bio], Disease, VARIANTS, Genome, State Medicine, NIHR BioResource for the 100,000 Genomes Project, 0302 clinical medicine, Medicine, GATA1 Transcription Factor, Genetics, Multidisciplinary, Translational bioinformatics, ASSOCIATION, 3. Good health, Multidisciplinary Sciences, Phenotype, 030220 oncology & carcinogenesis, disease genetics, Medical genetics, Science & Technology - Other Topics, Receptors, Thrombopoietin, medicine.medical_specialty, General Science & Technology, Quantitative Trait Loci, Genomics, Computational biology, Biology, DIAGNOSIS, computational biology and bioinformatics, Actin-Related Protein 2-3 Complex, Article, LRBA, LINKS, 03 medical and health sciences, Rare Diseases, Humans, Alleles, Adaptor Proteins, Signal Transducing, Whole genome sequencing, National health, Science & Technology, Whole Genome Sequencing, MUTATIONS, business.industry, THROMBOCYTOPENIA, United Kingdom, MACROTHROMBOCYTOPENIA, genetics research, 030104 developmental biology, business, Rare disease
Abstract

Most patients with rare diseases do not receive a molecular diagnosis and the aetiological variants and causative genes for more than half such disorders remain to be discovered1. Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the coding and non-coding regions of the genome. We generated WGS data for 13,037 participants, of whom 9,802 had a rare disease, and provided a genetic diagnosis to 1,138 of the 7,065 extensively phenotyped participants. We identified 95 Mendelian associations between genes and rare diseases, of which 11 have been discovered since 2015 and at least 79 are confirmed to be aetiological. By generating WGS data of UK Biobank participants2, we found that rare alleles can explain the presence of some individuals in the tails of a quantitative trait for red blood cells. Finally, we identified four novel non-coding variants that cause disease through the disruption of transcription of ARPC1B, GATA1, LRBA and MPL. Our study demonstrates a synergy by using WGS for diagnosis and aetiological discovery in routine healthcare.

Published
2021

44. Urine biomarkers for monitoring juvenile lupus nephritis: a prospective longitudinal study

Author

Watson, Louise, Tullus, Kjell, Pilkington, Clarissa, Chesters, Christine, Marks, Stephen D., Newland, Paul, Jones, Caroline A., and Beresford, Michael W.

Subjects
Systemic lupus erythematosus -- Research -- Risk factors -- Complications and side effects -- Care and treatment -- Patient outcomes -- Development and progression, Biological markers -- Research -- Physiological aspects, Health
Abstract

Background In juvenile-onset systemic lupus erythematosus (JSLE), renal involvement (lupus nephritis) is frequently seen and can result in long-term morbidity. This prospective longitudinal study aimed to identify the utility of standard and/or novel biomarkers for monitoring and predicting lupus nephritis in a real world setting. Methods Using an unselected JSLE cohort, urine samples were collected during routine clinical review. Protein concentrations of urinary monocyte chemo-attractant protein 1 (uMCP1) and neutrophil gelatinase-associated lipocalin (uNGAL) were analysed along with standard disease activity markers, and were compared with current and subsequent disease activity. Results JSLE patients (n = 64; median age 14.1 years) were seen at 3 (interquartile range: 2-5) clinical reviews over 364 (182-532) days. Multivariate analysis demonstrated uMCP1 and serum C3 as independent variables (p Keywords Lupus * Biomarker * Nephritis * MCP1 * NGAL * Lipocalin, Introduction In juvenile-onset systemic lupus erythematosus (JSLE) a preponderance of renal involvement (lupus nephritis; LN) is seen and has been described to occur in up to 80% of patients within [...]

Published
2014
Full Text
View/download PDF

45. Juvenile arthritis disease activity score is a better reflector of active disease than the disease activity score 28 in adults with polyarticular juvenile idiopathic arthritis

Author

Wu, Qiong, Chaplin, Hema, Ambrose, Nicola, Sen, Debajit, Leandro, Maria J, Wing, Charlotte, Daly, Nicola, Webb, Kate, Fisher, Corinne, Suffield, Linda, Josephs, Francesca, Pilkington, Clarissa, Eleftheriou, Despina, Al-Obaidi, Muthana, Compeyrot-Lacassagne, Sandrine, Wedderburn, Lucy R, and Ioannou, Yiannis

Published
2016
Full Text
View/download PDF

46. Experience with the use of mycophenolate mofetil in juvenile idiopathic inflammatory myopathies.

Author

Varnier, Giulia Camilla, Consolaro, Alessandro, Cheng, Iek Leng, Riveiro, Alicia Silva, Pilkington, Clarissa, and Ravelli, Angelo

Subjects
DRUG efficacy, SKIN diseases, KRUSKAL-Wallis Test, MYCOPHENOLIC acid, RETROSPECTIVE studies, VISUAL analog scale, FISHER exact test, SEVERITY of illness index, MUSCLE strength, DESCRIPTIVE statistics, CHI-squared test, MYOSITIS, DATA analysis software, LONGITUDINAL method, DRUG administration, DRUG dosage, THERAPEUTICS, CHILDREN, ADOLESCENCE
Abstract

Objective The objective of this study was to evaluate the efficacy and safety of MMF in juvenile idiopathic inflammatory myopathies (JIIMs). Methods Patients diagnosed with JIIM and treated with MMF enrolled in the Juvenile Dermatomyositis Research Group (JDRG) in the UK or followed at the Giannina Gaslini Institute in Genoa, Italy, were included. The following information was collected retrospectively at MMF initiation, at 3, 6 and 12 months after treatment start, and at last follow-up visit: clinical manifestations, laboratory data, physicians' subjective assessment of disease activity, standardized outcome measures of muscle strength/endurance, cutaneous disease activity, physical function, global disease activity, cumulative damage, and ongoing treatment. Results Of the 29 patients included, 23 had juvenile DM and 6 had overlap myositis. During administration of MMF, improvement in measures of muscle strength, skin disease activity, and overall disease activity was seen, with an increase in the frequency of normal scores for Manual Muscle Test-8 from 50.0% to 83.3%, Childhood Myositis Activity Score from 53.5% to 88.9%, muscle component of DAS from 55.2% to 84.2%, skin component of DAS from 31.0% to 42.1%, visual analogue scale for skin disease activity from 25.0% to 47.4%, and visual analogue scale for overall disease activity from 7.1% to 42.1%. The number of patients with inactive disease increased from 10.3% at baseline to 68.5% at last follow-up. CS dose was significantly reduced, from 0.3 to 0.1 mg/kg/day. No relevant side effects were reported. Conclusion Our experience suggests that MMF is a valuable therapeutic option for the management of JIIM. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

47. Panel sequencing links rare, likely damaging gene variants with distinct clinical phenotypes and outcomes in juvenile-onset SLE.

Author

Charras, Amandine, Haldenby, Sam, Smith, Eve M D, Egbivwie, Naomi, Olohan, Lisa, Kenny, John G, Schwarz, Klaus, Roberts, Carla, Al-Abadi, Eslam, Armon, Kate, Bailey, Kathryn, Ciurtin, Coziana, Gardner-Medwin, Janet, Haslam, Kirsty, Hawley, Daniel P, Leahy, Alice, Leone, Valentina, McErlane, Flora, Modgil, Gita, and Pilkington, Clarissa

Subjects
AUTOANTIBODIES, GENETIC mutation, SEQUENCE analysis, IMMUNOGLOBULINS, BLACK people, AGE distribution, GENETIC variation, AGE factors in disease, CARIBBEAN people, DESCRIPTIVE statistics, SYSTEMIC lupus erythematosus, PHENOTYPES, LONGITUDINAL method, DISEASE complications
Abstract

Objectives Juvenile-onset systemic lupus erythematosus (jSLE) affects 15–20% of lupus patients. Clinical heterogeneity between racial groups, age groups and individual patients suggests variable pathophysiology. This study aimed to identify highly penetrant damaging mutations in genes associated with SLE/SLE-like disease in a large national cohort (UK JSLE Cohort Study) and compare demographic, clinical and laboratory features in patient sub-cohorts with 'genetic' SLE vs remaining SLE patients. Methods Based on a sequencing panel designed in 2018, target enrichment and next-generation sequencing were performed in 348 patients to identify damaging gene variants. Findings were integrated with demographic, clinical and treatment related datasets. Results Damaging gene variants were identified in ∼3.5% of jSLE patients. When compared with the remaining cohort, 'genetic' SLE affected younger children and more Black African/Caribbean patients. 'Genetic' SLE patients exhibited less organ involvement and damage, and neuropsychiatric involvement developed over time. Less aggressive first line treatment was chosen in 'genetic' SLE patients, but more second and third line agents were used. 'Genetic' SLE associated with anti-dsDNA antibody positivity at diagnosis and reduced ANA, anti-LA and anti-Sm antibody positivity at last visit. Conclusion Approximately 3.5% of jSLE patients present damaging gene variants associated with younger age at onset, and distinct clinical features. As less commonly observed after treatment induction, in 'genetic' SLE, autoantibody positivity may be the result of tissue damage and explain reduced immune complex-mediated renal and haematological involvement. Routine sequencing could allow for patient stratification, risk assessment and target-directed treatment, thereby increasing efficacy and reducing toxicity. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

49. Contributors

Author

Abdellatif, Engy, primary, Abeles, Aryeh M., additional, Abelson, Abby G., additional, Abhishek, Abhishek, additional, Abramson, Steven B., additional, Adachi, Jonathan D., additional, Adams, Michael A., additional, Aigner, Thomas, additional, Akira, Shizuo, additional, Aletaha, Daniel, additional, Aliprantis, Antonios O., additional, Almeida de Jesus, Adriana, additional, Altman, Roy D., additional, Amigo, Mary-Carmen, additional, Aringer, Martin, additional, Ascherman, Dana P., additional, Assassi, Shervin, additional, Atamas, Sergei P., additional, Azevedo, Pedro Ming, additional, Baer, Alan N., additional, Baeten, Dominique, additional, Baines, Colin, additional, Baker, Nancy A., additional, Balogh, Emese, additional, Balsa, Alejandro, additional, Baraliakos, Xenofon, additional, Bardin, Thomas, additional, Barnsley, Les, additional, Bathon, Joan M., additional, Bauch, Angela, additional, Belch, Jill J.F., additional, Bellamy, Nicholas, additional, Bellido, Teresita, additional, Benjamin, Michael, additional, Beresford, Michael W., additional, Berman, Brian, additional, Bermas, Bonnie Lee, additional, Bertsias, George, additional, Bilezikian, John P., additional, Bilginer, Yelda, additional, Birnbaum, Julius, additional, Bishop, Felicity L., additional, Bleasel, Jane F., additional, Böhm, Markus, additional, Bolster, Marcy B., additional, Bombardieri, Stefano, additional, Bonelli, Michael, additional, Bonnick, Sydney L., additional, Boumpas, Dimitrios T., additional, Bozec, Aline, additional, Brasington, Richard D., additional, Braun, Juergen, additional, Brown, Matthew A., additional, Bruce, Ian N., additional, Bugbee, William D., additional, Bukhari, Marwan A.S., additional, Burgos-Vargas, Rubén, additional, Burmester, Gerd-Rüdiger, additional, Burns, Jane C., additional, Burr, David B., additional, Buttgereit, Frank, additional, Bykerk, Vivian P., additional, Calabrese, Leonard H., additional, Callen, Jeffrey P., additional, Cavallo, Sabrina, additional, Cawston, Tim E., additional, Chandran, Vinod, additional, Chard, Michael Denis, additional, Chaudhary, Prateek, additional, Chen, Lan X., additional, Choi, Hyon K., additional, Choy, Ernest H., additional, Christopher-Stine, Lisa, additional, Chu, Alvina D., additional, Clauw, Daniel J., additional, Clements, Philip J., additional, Clowse, Megan E.B., additional, Coghlan, J. Gerry, additional, Conaghan, Philip G., additional, Cooper, Cyrus, additional, Costenbader, Karen H., additional, Creamer, Paul, additional, Crispín, José C., additional, Cronstein, Bruce N., additional, Cross, Raymond, additional, Cusano, Natalie E., additional, Cutolo, Maurizio, additional, D'Adamo, Chris, additional, D'Agati, Vivette, additional, D'Cruz, David P., additional, Dagfinrud, Hanne, additional, Daikh, David I., additional, Dalbeth, Nicola, additional, Dalton, Seamus E., additional, Dass, Shouvik, additional, Davis, Aileen M., additional, De Ceulaer, Karel, additional, Deal, Chad L., additional, Deane, Kevin D., additional, Della Rossa, Alessandra, additional, Dellaripa, Paul F., additional, Dennison, Elaine, additional, Denton, Christopher P., additional, Dieppe, Paul, additional, Doherty, Michael, additional, Dolan, Patricia, additional, Donn, Rachelle, additional, Dvorkina, Olga, additional, Dyer, George S.M., additional, Eastell, Richard, additional, Edwards, N. Lawrence, additional, Emery, Paul, additional, Erturan, Gurhan, additional, Espinoza, Luis R., additional, Eyre, Steve, additional, Fanouriakis, Antonios C., additional, Farber, Joshua, additional, Farrokhi, Shawn, additional, Fasth, Anders, additional, Feist, Eugen, additional, Feldman, Debbie, additional, Felson, David T., additional, Fisk, John D., additional, Fitzgerald, G. Kelley, additional, Flores, Raymond H., additional, Fox, David A., additional, Francomano, Clair A., additional, Frangos, Jennifer, additional, Freemont, Anthony J., additional, Fricka, Kevin B., additional, Furst, Daniel E., additional, Gabay, Cem, additional, Gadina, Massimo, additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gensler, Lianne S., additional, Geraldino-Pardilla, Laura, additional, Gerlag, Danielle M., additional, Ginzler, Ellen M., additional, Gizinski, Alison M., additional, Gladman, Dafna D., additional, Gold, Garry E., additional, Goldbach-Mansky, Raphaela, additional, Goldingay, Sarah, additional, Gordon, Sharon M., additional, Gorodkin, Rachel, additional, Goronzy, Jörg J., additional, Görtz, Simon, additional, Grahame, Rodney, additional, Grainger, Andrew J., additional, Gravallese, Ellen M., additional, Greenberg, Jeffrey D., additional, Gujar, Bansari, additional, Hagan, Matilda, additional, Hagley, Karlene, additional, Hakim, Alan J., additional, Hall, John C., additional, Hamuryudan, Vedat, additional, Hanly, John G., additional, Hanson, Eric P., additional, Haraoui, Boulos, additional, Harley, John B., additional, Hashkes, Philip J., additional, Hawker, Gillian A., additional, Hawkins, Philip N., additional, Heiberg, Turid, additional, Heinegård, Dick, additional, Helfgott, Simon M., additional, Ho, Pauline Y.P., additional, Hochberg, Marc C., additional, Hochman, Jacqueline, additional, Hodgkiss-Harlow, Chelsea J., additional, Hoffman, Robert W., additional, Hoffmann, Markus, additional, Holers, V. Michael, additional, Holick, Michael F., additional, Holroyd, Christopher, additional, Hübscher, Osvaldo, additional, Hunter, David J., additional, Husni, M. Elaine, additional, Inman, Robert D., additional, Isaac, Zacharia, additional, Iversen, Maura D., additional, Jabs, Douglas A., additional, Jackson, William, additional, Jaimungal, Sarada, additional, James, Judith A., additional, Javier, Rose-Marie, additional, Johnsen, Alyssa K., additional, Jordan, Joanne M., additional, Kaisho, Tsuneyasu, additional, Kallenberg, Cees G.M., additional, Kane, David, additional, Kapoor, Mohit, additional, Karlson, Elizabeth W., additional, Kassimos, Dimitrios G., additional, Kastner, Daniel L., additional, Katz, Jeffrey N., additional, Kay, Jonathan, additional, Kelly, Jennifer A., additional, Keystone, Edward, additional, Khamashta, Munther A., additional, Khanna, Dinesh, additional, Kjeken, Ingvild, additional, Koch, Alisa E., additional, Koff, Matthew F., additional, Kottyan, Leah, additional, Koutsogeorgopoulou, Loukia A., additional, Kraus, Virginia Byers, additional, Kumar, Pradeep, additional, Kvien, Tore K., additional, Lafyatis, Robert, additional, Landewé, Robert B.M., additional, Langford, Carol A., additional, Lau, Arthur N., additional, Laxer, Ronald M., additional, Learch, Thomas J., additional, Lewith, George, additional, Li, Yi, additional, Liao, Katherine P., additional, Littlejohn, Geoffrey, additional, Lorenzo, Pilar, additional, Luger, Thomas A., additional, Lundberg, Ingrid E., additional, Lundberg, Karin, additional, Machold, Klaus P., additional, MacKenzie, C. Ronald, additional, Mahr, Alfred D., additional, Manheimer, Eric, additional, Marini, Joan C., additional, Marquez, Javier, additional, Marsden, Debbie, additional, Martel-Pelletier, Johanne, additional, Martín-Mola, Emilio, additional, Martínez-Lavín, Manuel, additional, Massarotti, Elena M., additional, Matteson, Eric L., additional, Matzat, Stephen J., additional, Mayahi, Reza, additional, Mayes, Maureen Davidica, additional, McAlindon, Timothy, additional, McBain, Hayley, additional, McCarberg, Bill, additional, McCarthy, Edward F., additional, McCarthy, Geraldine, additional, McDermott, Michael F., additional, McGonagle, Dennis, additional, McLean, Lachy, additional, Merkel, Peter A., additional, Mikdashi, Jamal A., additional, Miller, Frederick W., additional, Miller, Paul D., additional, Minden, Kirsten, additional, Monach, Paul A., additional, Mulligan, Kathleen, additional, Namur, Gauthier, additional, Naredo, Esperanza, additional, Naylor, Kim E., additional, Nelson, Amanda E., additional, Newman, Stanton P., additional, Nordal, Ellen, additional, Nöth, Ulrich, additional, Ntatsaki, Eleana, additional, O'Shea, John J., additional, Oddis, Chester V., additional, Olivé, Alejandro, additional, Omair, Mohammed A., additional, Ombrello, Michael J., additional, Omisade, Antonina, additional, Ong, Voon H., additional, Önnerfjord, Patrik, additional, Orcel, Philippe, additional, Ospelt, Caroline, additional, Ozen, Seza, additional, Paget, Stephen A., additional, Patel, Dipak R., additional, Patrono, Carlo, additional, Pelletier, Jean-Pierre, additional, Pereira, Rosa Maria Rodrigues, additional, Pilkington, Clarissa A., additional, Pillinger, Michael H., additional, Pineda, Carlos, additional, Plenge, Robert M., additional, Price, Andrew, additional, Pricop, Luminita, additional, Rackwitz, Lars, additional, Ravelli, Angelo, additional, Redmond, Anthony C., additional, Reeves, Westley H., additional, Remmers, Elaine F., additional, Requena, Luis, additional, Ribbens, Clio, additional, Richardson, Bruce C., additional, Riera Alonso, Elena, additional, Riley, Graham, additional, Ritchlin, Christopher, additional, Ritter, Susan Y., additional, Rosas, Ivan O., additional, Rowan, Drew D., additional, Rudwaleit, Martin, additional, Rull, Marina, additional, Rygg, Marite, additional, Saag, Kenneth G., additional, Salmon, Jane E., additional, Salter, Donald M., additional, Salzberg, Daniel J., additional, Sambrook, Philip N., additional, Saxne, Tore, additional, Schaible, Hans-Georg, additional, Scher, Jose U., additional, Schett, Georg, additional, Schmitz, Nicole, additional, Schreiber, Benjamin, additional, Schumacher, H. Ralph, additional, Schwartz, Daniella Muallem, additional, Scott, David G.I., additional, Seton, Margaret, additional, Shapiro, Lauren M., additional, Sharby, Nancy, additional, Siegel, Jeffrey, additional, Siegel, Richard M., additional, Sieper, Joachim, additional, Silver, Richard M., additional, Silverberg, Shonni J., additional, Simard, Julia F., additional, Simmons, Barry P., additional, Simms, Robert W., additional, Singer, Nora G., additional, Smith, Malcolm D., additional, Smith, Stacy E., additional, Smolen, Josef S., additional, Spector, Tim D., additional, Steen, Virginia D., additional, Steere, Allen C., additional, Steiner, Günter, additional, Steinert, Andre F., additional, Stojan, George, additional, Stone, John H., additional, Strand, Vibeke, additional, Straub, Rainer H., additional, Streeten, Elizabeth A., additional, Superti-Furga, Giulio, additional, Symmons, Deborah P.M., additional, Szekanecz, Zoltan, additional, Tak, Paul P., additional, Tavoni, Antonio, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Thomas, Sarah S., additional, Thorne, Jennifer E., additional, Tobias, Jonathan H., additional, Tremoulet, Adriana H., additional, Tsokos, George C., additional, Tuan, Rocky S., additional, Turesson, Carl, additional, Unizony, Sebastian H., additional, Valdes, Ana M., additional, van den Berg, Wim B., additional, van der Heijde, Désirée, additional, van Vollenhoven, Ronald Frits, additional, Varga, John, additional, Vassilopoulos, Dimitrios, additional, Vital, Edward M., additional, Walker-Bone, Karen, additional, Wallace, Daniel J., additional, Warburton, Gary, additional, Ward, Robert J., additional, Watts, Richard, additional, Wechalekar, Mihir D., additional, Wedderburn, Lucy R., additional, Weinblatt, Michael E., additional, Weir, Matthew R., additional, Wenham, Claire Y.J., additional, West, Sterling G., additional, Weyand, Cornelia M., additional, White, Kenneth E., additional, Winthrop, Kevin L., additional, Wong, John B., additional, Woolf, Anthony D., additional, Worthington, Jane, additional, Xu, Huji, additional, Yazici, Hasan, additional, Young, D.A., additional, Yurdakul, Sebahattin, additional, Zhang, Yuqing, additional, and Zhuang, Haoyang, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results