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2. Osteopontin as a Biomarker in Interstitial Lung Diseases

Author

David Iturbe-Fernández, Verónica Pulito-Cueto, Víctor M. Mora-Cuesta, Sara Remuzgo-Martínez, Diego J. Ferrer-Pargada, Fernanda Genre, Pilar Alonso-Lecue, Raquel López-Mejías, Belén Atienza-Mateo, Miguel A. González-Gay, and José M. Cifrián-Martínez

Subjects
interstitial lung disease, idiopathic pulmonary fibrosis, biomarkers, osteopontin, Biology (General), QH301-705.5
Abstract

Osteopontin (OPN) is a glycoprotein involved in Th1 and Th17 differentiation, and inflammation and tissue remodeling. OPN is a biomarker of disease activity in patients with autoimmune inflammatory conditions. This study aimed to assess the diagnostic and prognostic value of OPN in interstitial lung diseases (ILDs). Between May 2016 and October 2019, 344 patients with ILD were recruited at the Hospital Universitario Marqués de Valdecilla (Spain) and were prospectively followed-up. This study involved the determination of OPN serum levels by ELISA and OPN RNA expression quantified using qPCR. Six genetic polymorphisms in OPN (rs28357094, rs2853749, rs2853750, rs11728697, rs7695531, and rs1126616) were genotyped using TaqMan assays. OPN serum levels were also assessed in 140 healthy controls. OPN serum levels (median [interquartile range]) were significantly higher in ILD patients than in controls (1.05 [0.75–1.51] ng/mL versus 0.81 [0.65–0.98] ng/mL in healthy controls; p < 0.01). OPN serum levels were inversely correlated with the forced vital capacity. OPN serum levels were also higher in ILD patients who died or underwent lung transplantation when compared with the remaining ILD patients (1.15 [0.80–1.72] ng/mL versus 0.99 [0.66–1.32] ng/mL; p = 0.05). Survival worsened in ILD patients with OPN > 1.03 ng/mL at 1, 3, and 5 years. No statistically significant differences in the genetic frequencies of OPN polymorphisms or the RNA expression were found among the different ILD groups. Elevated levels of OPN in the serum may be a useful indicator in identifying patients with ILD who are more likely to experience poor outcomes.

Published
2024
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3. Simplified risk stratification based on cardiopulmonary exercise test: A Spanish two‐center experience

Author

Amaya Martínez‐Meñaca, Alejandro Cruz‐Utrilla, Víctor Manuel Mora‐Cuesta, Raquel Luna‐López, Teresa Segura‐de la Cal, Ángela Flox‐Camacho, Pilar Alonso‐Lecue, Pilar Escribano‐Subias, and José Manuel Cifrián‐Martínez

Subjects
cardiopulmonary exercise test, pulmonary arterial hypertension, risk assessment, 6 min walking test, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779
Abstract

Abstract A simplified 4‐strata risk stratification approach based on three variables is widespread in pulmonary arterial hypertension (PAH) at follow‐up. This study aimed to assess the impact of replacing the 6‐min walk test (6MWT) with the peak 02 uptake evaluated by the cardiopulmonary exercise test (CPET) on risk stratification by this scale. We included 180 prevalent patients with PAH from two reference hospitals in Spain, followed up between 2006 and 2022. Patients were included if all the variables of interest were available within a 3‐month period on the Spanish Registry of Pulmonary Arterial Hypertension (REHAP): functional class (FC); NT‐proBNP; 6MWT; and CPET. The original 4‐strata model (NT‐proBNP, 6MWT, FC) identified most patients at low or intermediate‐low risk (36.7% and 51.1%, respectively). Notably, the modified scale (NT‐proBNP, CPET, FC) improved the identification of patients at intermediate‐high risk up to 18.9%, and at high risk up to 1.1% in comparison with the previous 12.2% and 0.0% in the original scale. This new model increased the number of patients correctly classified into higher‐risk strata (positive NRI of 0.06), as well as classified more patients without events in lower‐risk strata (negative NRI of 0.04). The proposed score showed a slightly superior prognostic capacity compared with the original model (Harrel's C‐index 0.717 vs. 0.709). Using O2 uptake instead of distance walked in the 6MWT improves the identification of high‐risk patients using the 4‐strata scale. This change could have relevant prognostic implications and lead to changes in the specific treatment of PAH.

Published
2024
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4. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysisResearch in context

Author

Miquel Àngel Sastre-Femenia, Almudena Fernández-Muñoz, María Antonia Gomis-Font, Biel Taltavull, Carla López-Causapé, Jorge Arca-Suárez, Luis Martínez-Martínez, Rafael Cantón, Nieves Larrosa, Jesús Oteo-Iglesias, Laura Zamorano, Antonio Oliver, Fátima Galán-Sánchez, Irene Gracia-Ahufinger, Carmen Liébana-Martos, Carolina Roldán, Juan Manuel Sánchez-Calvo, Encarnación Clavijo, Laura Mora-Navas, Javier Aznar, José Antonio Lepe, Ángel Rodríguez-Villodres, Esther Recacha, Francisco Javier Casas-Círia, Carmen Martínez-Rubio, Marco Antonio Sempere-Alcocer, Lina Martín-Hita, Cristina Seral, Ana Isabel López-Calleja, Carmen Aspiroz, Marisa Monforte, Pedro de la Iglesia-Martínez, Gemma Jimenez-Guerra, Elena Riera-Pérez, Carmen Collado, Carmen Gallegos, Xavier Mulet, Miquel Àngel Sastre-Femenía, María Siller-Ruiz, Jorge Calvo, Dolores Quesada, Jun Hao Wang, Cristina Pitart, Francesc Marco, Nuria Prim, Juan Pablo Horcajada, Eduardo Padilla, Ester Del Barrio-Tofiño, Belen Viñado-Pérez, Fe Tubau, Silvia Capilla, Antonio Casabella, Mar Olga Pérez-Moreno, Emma Padilla, Mónica Ballestero, Alba Rivera, Ferrán Navarro, Fréderic Gómez-Bertomeu, Sergio Pardo-Granell, Ester Picó-Plana, Dolores Guerrero, Carolina Sarvisé-Buil, Alba Belles-Belles, Marta Fernández-Esgueva, María del Pilar Ortega-Lafont, Inmaculada García, Noelia Arenal-Andrés, Susana Hernando-Real, Rosario Ibáñez, Jesús Martínez, Federico Becerra, Carmen Aldea-Mansilla, Asmaa Alaoui-Sosse, José Carlos González, Julia Guzman-Puche, Miguel Ángel Blázquez-Andrada, Nora Mariela Martínez-Ramírez, Alicia Beteta, Bárbara Gomila-Sard, Salvador Giner Almaraz, Eugenio Garduño, Pedro Miguel Juiz-González, Javier Alba, Pilar Alonso, Ana Isabel Rodríguez, María Isabel Paz-Vidal, Marta García-Campello, Pablo Camacho, María de los Ángeles Pallarés, María Luisa Pérez del Molino, Amparo Coira, Gema Barbeito, Anniris Rincón, Francisco José Vasallo-Vidal, Laura Alonso-Acero, Laura Iglesias-Llorente, Ana Bordes-Benites, Laura Florén-Zabala, José Manuel Azcona, Carla Andrea Alonso, Yolanda Sáenz, Marta Lamata-Subero, David Molina, Ana González-Torralba, Jennifer Villa, Esther Viedma, Emilia Cercenado, Teresa Alarcón, Paula Vargas, María Díez, Patricia Ruiz, María Isabel Sánchez-Romero, Felipe Pérez-García, Genoveva Yagüe-Guirao, Amaia Concepción Oteiza, José Leiva, María Eugenia Portillo, Andrés Canut-Blasco, Matxalen Vidal, Iker Alonso, Maider Zuriarrain, and José Luis Barrios-Andrés

Subjects
Post-acute sequelae of SARS-CoV-2, PASC, COVID-19, SARS-CoV-2, Electronic health records, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: Pseudomonas aeruginosa healthcare-associated infections are one of the top antimicrobial resistance threats world-wide. In order to analyze the current trends, we performed a Spanish nation-wide high-resolution analysis of the susceptibility profiles, the genomic epidemiology and the resistome of P. aeruginosa over a five-year time lapse. Methods: A total of 3.180 nonduplicated P. aeruginosa clinical isolates from two Spanish nation-wide surveys performed in October 2017 and 2022 were analyzed. MICs of 13 antipseudomonals were determined by ISO-EUCAST. Multidrug resistance (MDR)/extensively drug resistance (XDR)/difficult to treat resistance (DTR)/pandrug resistance (PDR) profiles were defined following established criteria. All XDR/DTR isolates were subjected to whole genome sequencing (WGS). Findings: A decrease in resistance to all tested antibiotics, including older and newer antimicrobials, was observed in 2022 vs 2017. Likewise, a major reduction of XDR (15.2% vs 5.9%) and DTR (4.2 vs 2.1%) profiles was evidenced, and even more patent among ICU isolates [XDR (26.0% vs 6.0%) and DTR (8.9% vs 2.6%)] (p

Published
2023
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5. Elevated pulse pressure and cardiovascular risk associated in Spanish population attended in primary care: IBERICAN study

Author

Ana Moyá-Amengual, Antonio Ruiz-García, Vicente Pallarés-Carratalá, Adalberto Serrano-Cumplido, Miguel Ángel Prieto-Díaz, Antonio Segura-Fragoso, Sergio Cinza-Sanjurjo, the researchers of the IBERICAN study, Alfonso Barquilla García, Ángel Díaz Rodríguez, Carlos Escobar Cervantes, Francisco Javier Alonso Moreno, Jesús Vergara Martín, Juan José Badimón, José Polo García, Luis Rodríguez Padial, Miguel Ángel Prieto, Rafael Vidal Pérez, Sergio Cinza Sanjurjo, Sònia Miravet Jiménez, Sonsoles Velilla Zancada, José Ramón Banegas, Vicente Martín Sánchez, Vicente Pallares Carratalá, Antonio Segura Fragoso y Rafael Manuel Micó Pérez, Antonio López Téllez, Jesús Vergara Martin, María De Los Ángeles Ortega Osuna, Cristóbal Prieto Cid, Mª José Hidalgo Fajardo, José Lorente Serna, Ángel Domínguez Requena, Ricardo Alberola Cañizares, Manuel Ruiz Peña, Filomena Herrero Collado, Marcela Montes Vázquez, Rafael Ángel Carrascal Garrido, María Reyes Herrera Lozano, Beatriz Ortiz Oliva, Francisco José Anguita, Carmen Pérez Ibáñez, Carlos Alberto Cabrera Rodríguez, María José Cruz Rodríguez, Sandra Bonilla Ruiz, Rocio Reina González, Salome Abad Sánchez, Inmaculada Santana Martínez, Rafael Sánchez Jordán, Juan Mª Ramos Navas-Parejo, José Manuel Ramírez Torres, José María Beltrán Poveda, María Adoración De Cruz Benayas, Carmen Fernández Gil, Jon Iñaki Esturo Alcaine, Antonio Mora Quintero, Fernando Leiva Cepas, José Luis Carrasco Martín, Emilio García Criado, Mercedes Vázquez Blanco, Isabel Mora Ortiz, Leovigildo Ginel Mendoza, Juan Carlos Aguirre Rodríguez, Esperanza María Romero Rodríguez, José Acevedo Vázquez, Juan Gabriel García Ballesteros, María De La Paz Fernández Lara, Patricia Agüera Moreno, Eduardo Paños Maturana, Juan Manuel Ignacio Expósito, Noelia Carrillo Peñas, Carmen María Abad Faya, Ana Marina Almagro Duque, Rubén Torrescusa Camisón, Paloma Menéndez Polo, Marina Peña García, Cristina López Fernández, Ascensión Estepa Torres, Miguel Gutiérrez Jansen, Esperanza Loizaga González, Lisardo García Matarín, Enrique José Gamero De Luna, Javier Benítez Rivero, María José Gómez González, Carmen Gómez Montes, Juan Carlos Rodríguez Rodríguez, Juana María González Barranco, Josefa Ramírez Vizcaíno, María Ángeles Miranda Sánchez, Eva Trillo Calvo, Concepción Bayod Calvo, Susana Larripa De La Natividad, German Grasa Lambea, Emilio Jiménez Marín, Ana Cristina Navarro Gonzalvo, Antonio Pablo Martínez Barseló, Irene Peña León, Ángel González Pérez, Liliana Mahulea, María José Pérez Martínez, Ana Piera Carbonell, Margarita Alonso Fernández, María Montserrat Rueda Cuadrado, Rodrigo Abad Rodríguez, José Miguel Álvarez Cabo, Rubén Sánchez Rodríguez, Eva María Cano Cabo, Anny Romero Secin, Miguel Ángel Prieto Díaz, Juan Jesús García Fernández, Saúl Suárez García, Fernando García Romanos, Antonia Moreno González, María Lara Amengual Sastre, Susana Martínez Palli, José Alfonso Ramón Bauza, Jose Ortiz Bolinches, Carmen Fernández Fernández, María Isabel Orlandis Vázquez, Ana Sanchís Mezquita, Fernando Unceta Aramburu, Juan Fernando Peiró Morant, Ana Moyá Amengual, Matéu Seguí-Díaz, José Félix Zuazagoitia Nubla, Ana Echevarría Ituiño, Gregorio Mediavilla Tris, María Carmen Noriega Bosch, Esther González, María Luisa Ruiz Macho, Ruth Sendino Del Olmo, Asunción Olagorta De Prado, Ana López De Viñaspre Muguerza, Jesús Iturralde Iriso, Mª Rosario Virtus Iñurrieta, Lucas Ulloa Bahamonde, Isidro Godoy García, Fernando Rubio Sevillano, María Isabel González González, Marta Pérez Souto, Raquel De León Contreras, Sara Isabel Almeida González, Irene Almería Diez, Virginia Maria Mirabal Sánchez, Francisco José Escobar Lavado, Yoel Anta Pérez, Nayra Sánchez Hernández, Juan Luis Alonso Jerez, Ricardo Koch, Nayra Ramírez Mendoza, Héctor Suárez Hernández, Francisco Jesús Morales Escobar, E Lidia Gutiérrez Fernández, Fernando Andrés Mantecón, Ana Belén García Garrido, Asunción Vélez Escalante, Luisa Alonso Rentería, Jesús Sainz Jiménez, Guillermo Pombo Alles, Esperanza Rueda Alonso, Juan Antonio Divisón Garrote, Pedro Martínez Sotodosos, Juan Antonio Vivancos Fuster, María García Palencia, José Ambrosio Torres Moraleda, Sara González Ballesteros, Ana Carmen Gil Adrados, Antonio González Cabrera, Miguel Ángel Babiano Fernández, Guillermo Rico García, Juan José Criado-Álvarez, Pilar Torres Moreno, Francisco Javier Arribas Aguirregaviria, Alicia Sahuquillo Martínez, Lourdes Maria Santos Bejar, Miguel Laborda Peralta, Raúl Piedra Castro, Carlos Santos Altozano, Lucia González-Tarrio Polo, Pedro Valiente Maresca, Reinilda Mota Santana, Noemi Elizabeth Terrero Ledesma, Noelia Garrido Espada, Gabriela Delia Rosa Zambrana Calvi, Cristina de Castro Mesa, Blanca Cordero García, Pilar Sorrius Sitges, Ana María de Santiago Nocito, César Lozano Suárez, Juan Lorenzo Gutiérrez Montero, Juan Ignacio López Gil, María Dolores Fernández Ortega, Miren Elizari Roncal, María Ascensión López Serrano, Nuria Esther Adrián De La Fuente, Belén Angulo Fdez. De Larrea, Naiara Cubelos Fernández, Guiomar Luz Ferreiro Gómez, Diana Gómez Rodríguez, Sonia María Andrés Tuñón, María Ajenjo González, Serafín De Abajo Olea, Juan José León Regueras, César Manuel Gallego Nieto, Delio Vázquez Mallada, Maria De La O Gutiérrez García, Pablo Baz Rodríguez, José Ignacio Ferradal García, Blanca Delia De Román Martínez, Ana Arconada Pérez, Omar Mahmoud Atoui, Álvaro Morán Bayón, María Teresa Armenteros Del Olmo, Francisco Javier García-Norro Herreros, Enrique Méndez Rodríguez, Diana María Narganes Pineda, Verónica Ortiz Ainaga, Milagros Sonlei Sánchez Guevara, Laura Villota Ferreiro, M Teresa Grande Grande, Francisco Vicente Martínez Gracia, Jesús Palomo del Arco, María Dolores Moriano García, Beatriz Jiménez Muñoz, Gemma Rovira Marcelino, Diana Elizabeth Fernández Valverde, Roser Rodó Bernadó, Maria Teresa Ortiz Lupiañez, Najlaa Najih, José María Diéguez Parra, Mª Rosa Benedicto Acebo, Mari Luz Bravo Vicien, Alberto Ramón León Estella, Juan Antonio Muñoz Gómez, Alicia Mostazo Muntané, Isabel Ortega Abarca, Anna Gasol Fargas, Brenda Elizabeth Riesgo Escudero, Susana Elizabeth Riesgo, Edgar Zaballos Castellvi, Celia Cols Sagarra, Marta Herranz Fernández, Josep Alins Presas, Idaira Damas Pérez, Rosa M Alcolea Garcia, Ines Monte Collado, Roberto Genique Martínez, María José Guasch Villanueva, Teresa Rama Martínez, Lucio Pinto Pena, Josefa María Panisello Royo, Inés Gil Gil, Carlos Gómez Ruiz, Rita Sahun Font, Anna Fuentes Lloveras, Alberto Calderón Montero, María Del Mar Zamora Gómez, Elena Alarcón Cebrián, Mª José Piñero Acin, Celia Pecharroman Sacristán, M Soledad Mayayo Vicente, Mª Paz Pérez Unanua, Nuria Marañón Henrich, Saray Gómez Monreal, Sonia Redondo De Pedro, Blanca Sanz Pozo, Irene Moreno Martínez, Beatriz Lopez Uriarte, Carmelina Sanz Velasco, Amaya Gárriz Aguirre, Montserrat Rivera Teijido, German Reviriego Jaén, Jose Ignacio Aza Pascual-Salcedo, Josefa Vázquez Gallego, Julia Caballer Rodilla, Aida Herrera, Ezequiel Arranz Martínez, Ana María Gómez Calvo, Paula Morán Oliva, Mª Milagros González Béjar, Julio Antonio Heras Hitos, Olga García Vallejo, Manuel De Jesús Frías Vargas, María Jesús Castillejo Boguerin, Aurora García Lerín, Miguel Ángel María Tablado, Elena Concepción García García, Leticia De Miguel Acero, Carmen Zárate Oñate, Aránzazu Barranco Apoita, María Ester Montes Belloso, Ana María Huertas Velasco, Rafael Sáez Jiménez, Julia Natividad García Pascual, María Clemencia Zuluaga Zuluaga, Mª Cruz Díez Pérez, Antonio Ruiz García, Cristina Murillo Jelsbak, Virginia Lasso Oria, Amelia González Gamarra, Elena Rodilla Rodilla, Alberto Galgo Nafría, María Mestre de Juan, Mª Carmen García Albiñana, Mª del Pilar Moreno Cano, Paula Hernanz López, Paloma Casado Pérez, Jacinto Espinosa García, José Ignacio Prieto Romo, Leandro Fernández Fernández, Javier Sierratapia, Nieves Moreno Regidor, Francisco Javier Zaballos Sánchez, Ana Moreno Moreno, Francisco Carramiñana Barrera, Juan Jose Torres Vázquez, María José Gamero Samino, Miguel Ángel De Santiago Rodríguez, Pablo Rafael Gómez Martínez, Antonio Carlos Elías Becerra, Javier Soto Olivera, Víctor Cambero, Julián Domínguez Ávila, Andrés Simón Fuentes, Jorge Manuel De Nicolás Jiménez, Dimas Igual Fraile, Guadalupe Nieto Barco, Ignacio Araujo Ramos, Mª Luz Serrano Berrocal, Francisco Buitrago Ramírez, Minerva Gallego Marcos, Félix Suarez González, Victoriano Chavero Carrasco, Francisco Guerra Peguero, Francisco Javier Sánchez Vega, Manuel Tejero Mas, Alba Palmerín Donoso, Miguel Turégano Yedro, María Beatriz Esteban Rojas, Fátima Cabezudo Moreno, Nawson Elver Quevedo Saldaña, María Del Mar García Fenés, Timotea Garrote Florencio, José María Fernández Toro, Vicente Caballero Pajares, María José Gómez Barquero, Alejandra Rey Rañal, Elena García Del Río, Enrique Nieto Pol, Julio Álvarez Fernández, Pilar Alonso Álvarez, Mª Luisa Jorge Gómez, Antonio Calvo Guerrero, Isabel Celemín Colomina, Lucia Barreiro Casal, Juana Fernández Moreno, Mª Angelines Carballal Martínez, Nabor Díaz Rodríguez, Carlos Moral Paredes, Dolores Recarey García, Francisco Javier Iglesias Mato, Antonio Fouz Ulloa, Amparo Fidalgo González, Noelia Dios Parada, Patricia Conde Sabarís, Ana Isabel Rodríguez Pérez, Ana Inés García Palacio, Víctor Julio Quesada Varela, Lidia Romero Iglesias, Ángel Lado Llerena, Carmen Lires Rodríguez, María Luisa Carretero Díaz, José Carreira Arias, José Luís Vázquez Camino, María Del Carmen Torreiro Penas, Sandra Yáñez Freire, Daniel Rey Aldana, Carlos Piñeiro Díaz, Portal González Lorenzo, José Rodríguez Campos, Rubén Blanco Rodríguez, Manuel Portela Romero, Lucía Vilela de Castro, Sonsoles María Velilla Zancada, Rafael Crespo Sabarís, Oscar Fernando Isaula Jiménez, Jesús Manuel González Puga, Jorge Antonio Benaín Ávila, Óscar Del Toro González, Vicente Llorca Bueno, Ana María Ballesteros Pérez, Domingo J Rubira López, Mª Dolores Esteve Franco, Elena Sánchez Pablo, María Teresa Palacios López, Juan Castillo Meroño, José María Lobo Martínez, Isabel María Peral Martínez, J Eduardo Carrasco Carrasco, Armando Santo González, Juan Gomáriz García, Beatriz Ríos Morata, Laura Sánchez Iñigo, Inés Sanz Pérez, Vicente Pascual Fuster, Mª Dolores Aicart Bort, Natividad Vázquez Gómez, Carlos Lluna Gasco, Teresa Amorós Barber, Pedro Antonio Medina Cano, Miguel Monteagudo Moncho, María Jesús Larré Muñoz, Raquel Navarro Hernández, Francisco José Martínez Egea, Antonio Tramontano, Marta Ferrer Royo, Belén Persiva Saura, Juan A Contreras Torres, José Mª Tirado Moliner, Alejandro Salanova Penalba, Ariadna Cucó Alberola, Fernando María Navarro I Ros, Enrique Beltrán Llicer, Ana Seoane Novás, Inmaculada Martín Valls, Gracia Verdú Mahiques, Enrique Peña Forcada, Nieves Aguilar Gómez, Francisco Javier Sanz García, María Dolores Paradís Bueso, María Eugenia Alegre Romero, Antonio Francés Camus, María Amparo Antón Peinado, Rosa Latorre Santos, Mª Asunción Palomar Marín, María Carmen Botella García, Eva Sánchez Fresquet, Pedro Sala Paños, Tomás Sánchez Ruiz, Rosa Ana Valero Valero, María Seoane Vicente, Magdalena Martin Llinares, Antonio Masiá Alegre, José Luis Llisterri Caro, Irene Lluch Verdu, Vicente Pallarés Carratalá, Francisco Valls Roca, Rafael Manuel Micó Pérez, Carmen Barceló Dupuy, Elena Benages Vicente, María José Gimeno Tortajada, Mercedes Calleja del Ser, Martín Menéndez Rodríguez, and Rosalía Victoria Carbonell Castelló

Subjects
hypertension, pulse pressure, cardiovascular risk factors, subclinical target organ damage, hypertensive cardiovascular disease, cardiovascular disease, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

IntroductionElevated pulse pressure (ePP) is an independent marker of cardiovascular risk (CVR) in people older than 60, and a functional marker of subclinical target organ damage (sTOD) which can predict cardiovascular events in patients with hypertension (HTN), regardless of sTOD.ObjectiveTo evaluate the prevalence of ePP in adult population seen in primary care and its association with other vascular risk factors, sTOD and with cardiovascular disease (CVD).Materials and methodsObservational multicentre study conducted in Spain (8,066 patients, 54.5% women) from the prospective cohort study IBERICAN recruited in Primary Care. Pulse pressure (PP) was defined as the difference between the systolic blood pressure (SBP) and the diastolic blood pressure (DBP) ≥60 mmHg. Adjusted (for age and sex) ePP prevalence were determined. Bivariate and multivariate analyses of the possible variables associated with ePP were carried out.ResultsThe mean of PP was 52.35 mmHg, and was significantly higher (p

Published
2023
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6. Lack of concordance between the different exercise test measures used in the risk stratification of patients with pulmonary arterial hypertension

Author

Víctor M. Mora Cuesta, Amaya Martínez Meñaca, David Iturbe Fernández, Sandra Tello Mena, Pilar Alonso Lecue, Daniel Fernández Márquez, Begoña Sáinz‐Ezquerra Belmonte, María José Gallardo Ruiz, and José Manuel Cifrián Martínez

Subjects
cardiopulmonary exercise test, pulmonary arterial hypertension, risk assessment, 6‐min walking test, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779
Abstract

Abstract In pulmonary arterial hypertension (PAH) patients it is essential to perform a prognostic assessment to optimize the treatment. The aim of this study is to evaluate the risk stratification concordance assessed with different exercise test variables in a cohort of PAH patients. A retrospective analysis was performed using patient data registered in the PAH unit. Only those patients in whom the mean time elapsed between the 6‐min walking test (6MWT) and the cardiopulmonary exercise test (CPET) was a maximum of 6 months were selected. A total of 140 records from 40 patients were finally analyzed. When it came to assessing the concordance between the two exercise tests in the guidelines (CPET and 6MWT), up to 84.3% of the records did not coincide in terms of the risk stratification. Exclusively considering the CPET parameters, most of the records (75%) failed to include all three variables in the same risk category. When analyzing the VO2 alone, up to 40.7% of the tests yielded different risk classifications depending on whether the parameter was expressed. In conclusion, there is a low concordance between the two proposed exercise tests. These results should be a call for reflection on whether the cut‐off points set for the exercise tests proposed for the current risk stratification are adequate to achieve a correct risk stratification or whether they require an appropriate revision.

Published
2022
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8. Benchtop NMR-Based Metabolomics: First Steps for Biomedical Application

Author

Pilar Alonso-Moreno, Ignacio Rodriguez, and Jose Luis Izquierdo-Garcia

Subjects
nuclear magnetic resonance, metabolomics, benchtop, low field, diabetes, tuberculosis, Microbiology, QR1-502
Abstract

Nuclear magnetic resonance (NMR)-based metabolomics is a valuable tool for identifying biomarkers and understanding the underlying metabolic changes associated with various diseases. However, the translation of metabolomics analysis to clinical practice has been limited by the high cost and large size of traditional high-resolution NMR spectrometers. Benchtop NMR, a compact and low-cost alternative, offers the potential to overcome these limitations and facilitate the wider use of NMR-based metabolomics in clinical settings. This review summarizes the current state of benchtop NMR for clinical applications where benchtop NMR has demonstrated the ability to reproducibly detect changes in metabolite levels associated with diseases such as type 2 diabetes and tuberculosis. Benchtop NMR has been used to identify metabolic biomarkers in a range of biofluids, including urine, blood plasma and saliva. However, further research is needed to optimize the use of benchtop NMR for clinical applications and to identify additional biomarkers that can be used to monitor and manage a range of diseases. Overall, benchtop NMR has the potential to revolutionize the way metabolomics is used in clinical practice, providing a more accessible and cost-effective way to study metabolism and identify biomarkers for disease diagnosis, prognosis, and treatment.

Published
2023
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9. Antifungal Combination Eye Drops for Fungal Keratitis Treatment

Author

Victoria Díaz-Tomé, Carlos Bendicho-Lavilla, Xurxo García-Otero, Rubén Varela-Fernández, Manuel Martín-Pastor, José Llovo-Taboada, Pilar Alonso-Alonso, Pablo Aguiar, Miguel González-Barcia, Anxo Fernández-Ferreiro, and Francisco J. Otero-Espinar

Subjects
fungal keratitis, cyclodextrin, natamycin, voriconazole, PET/CT imaging, nuclear magnetic resonance, Pharmacy and materia medica, RS1-441
Abstract

Fungal keratitis (FK) is a corneal mycotic infection that can lead to vision loss. Furthermore, the severity of FK is aggravated by the emergence of resistant fungal species. There is currently only one FDA-approved formulation for FK treatment forcing hospital pharmacy departments to reformulate intravenous drug preparations with unknown ocular bioavailability and toxicity. In the present study, natamycin/voriconazole formulations were developed and characterized to improve natamycin solubility, permanence, and safety. The solubility of natamycin was studied in the presence of two cyclodextrins: HPβCD and HPγCD. The HPβCD was chosen based on the solubility results. Natamycin/cyclodextrin (HPβCD) inclusion complexes characterization and a competition study between natamycin and voriconazole were conducted by NMR (Nuclear Magnetic Resonance). Based on these results, several eye drops with different polymer compositions were developed and subsequently characterized. Permeability studies suggested that the formulations improved the passage of natamycin through the cornea compared to the commercial formulation Natacyn®. The ocular safety of the formulations was determined by BCOP and HET-CAM. The antifungal activity assay demonstrated the ability of our formulations to inhibit the in vitro growth of different fungal species. All these results concluded that the formulations developed in the present study could significantly improve the treatment of FK.

Published
2022
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10. Treatment planning considerations for 125I eye plaque brachytherapy

Author

David Miguel, Jesús María de Frutos, Francisco López-Lara, Pilar Alonso, Patricia Diezhandino, María Antonia Saornil, and Ciro García

Subjects
treatment planning optimization, episcleral brachytherapy, Medicine
Abstract

Effective cancer brachytherapy requires a treatment plan that delivers high-dose to tumor, while minimizing the dose to critical normal tissues. Therefore, an accurate knowledge of the sources and magnitude of the techniques is essential for producing robust and well optimized-plans. The purpose of this technical note is to establish general procedures and strategies for optimization and customization of the plaques loaded with radioactive seeds, particularly focusing on the definition of useful tactics to limit high doses to organs at risk and adapt the treatment time to the necessity of institution.

Published
2019
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11. Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease

Author

Sara Remuzgo-Martínez, Fernanda Genre, Verónica Pulito-Cueto, Belén Atienza-Mateo, Víctor Manuel Mora Cuesta, David Iturbe Fernández, Sonia María Fernández Rozas, Leticia Lera-Gómez, Pilar Alonso Lecue, María Piedad Ussetti, Rosalía Laporta, Cristina Berastegui, Amparo Solé, Virginia Pérez, Alicia De Pablo Gafas, Oreste Gualillo, José Manuel Cifrián, Raquel López-Mejías, and Miguel Ángel González-Gay

Subjects
interstitial lung disease, idiopathic interstitial pneumonia, vascular endothelial growth factor, biomarker, genetics, Biology (General), QH301-705.5
Abstract

The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients.

Published
2021
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12. Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic Slippage

Author

Ana Freije, Rut Molinuevo, Laura Ceballos, Marta Cagigas, Pilar Alonso-Lecue, René Rodriguez, Pablo Menendez, Daniel Aberdam, Ernesto De Diego, and Alberto Gandarillas

Subjects
Biology (General), QH301-705.5
Abstract

Tumor suppressor p53 is a major cellular guardian of genome integrity, and its inactivation is the most frequent genetic alteration in cancer, rising up to 80% in squamous cell carcinoma (SCC). By adapting the small hairpin RNA (shRNA) technology, we inactivated endogenous p53 in primary epithelial cells from the epidermis of human skin. We show that either loss of endogenous p53 or overexpression of a temperature-sensitive dominant-negative conformation triggers a self-protective differentiation response, resulting in cell stratification and expulsion. These effects follow DNA damage and exit from mitosis without cell division. p53 preserves the proliferative potential of the stem cell compartment and limits the power of proto-oncogene MYC to drive cell cycle stress and differentiation. The results provide insight into the role of p53 in self-renewal homeostasis and help explain why p53 mutations do not initiate skin cancer but increase the likelihood that cancer cells will appear.

Published
2014
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13. Árboles de clasificación de Potimirim mexicana (Decapoda: Caridea), organismo hermafrodita protándrico secuencial

Author

José Luis Bortolini, Pilar Alonso, and Fernando Alvarez

Subjects
árboles de clasificación, Potimirim mexicana, Atyidae, Caridea, Aquaculture. Fisheries. Angling, SH1-691, Oceanography, GC1-1581, Biology (General), QH301-705.5
Abstract

Se presenta un análisis estadístico de variables morfométricas del camarón de agua dulce Potimirim mexicana, que ha sido descrito como hermafrodita protándrico secuencial. El objetivo es probar estadísticamente, que los organismos pueden ser clasificados por sexo, analizando su longitud y otras variables morfológicas. Un total de 191 organismos fueron capturados en el río Máquinas, Veracruz, México. La técnica utilizada fue la de árboles de clasificación, que mediante probabilidades van determinando las variables significativas en la variable "respuesta", así como las que son necesarias para la discriminación. Esta técnica permitió corroborar la teoría que la longitud total del organismo es necesaria para la discriminación de la variable sexo, pero también generó el resultado que, estadísticamente, dos variables más son importantes en este proceso discriminatorio; el largo del segundo pleópodo y largo del carpo del tercer pereiópodo. La técnica generó un clasificación correcta de 82% utilizando las tres variables mencionadas. Lo significativo del proceso es que al generar los árboles de clasificación se muestran, de manera sencilla y práctica, las variables necesarias en este proceso, así como su nivel discriminatorio individual.

Published
2013

14. Claves para la comprensión y el aprendizaje del concepto de coherencia discursiva

Author

Pilar Alonso Rodríguez

Subjects
Language and Literature, Philology. Linguistics, P1-1091
Abstract

This article tackles the concept of discourse coherence, and its importance in the processes of language production and comprehension. It deals with the problems which may occur when the concept has to be explained to students of English as a foreign language, who may not be able to approach it intuitively. It proposes using seven key notions based on semantic discourse analysis to show how coherence is achieved and developed in English. The notions are explained and then applied to a real text in English.

Published
2013
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15. Los verbos modales ingleses : organización en contexto oracional libre y restringido

Author

María Jesús Sánchez and Pilar Alonso

Subjects
cognitiva, organización, verbos modales, inglés, pathfinder, contexto, enseñanza, aprendizaje, Language and Literature, Philology. Linguistics, P1-1091
Abstract

The aim of this paper is to study the cognitive organization which native and nonnative speakers of English present with regard to modal verbs in English This was inferred from the semantic networks, obtained with the Pathfinder procedure (Schvaneveldt 1990; Schvaneveldt, Durso and Dearholt, 1989; Schvaneveldt, Durso, Goldsmith, Breen, Cooke, Tucker and De Maio 1985; Thompson, Gomez and Schvaneveldt, 2000), of two groups of subjects (native and non-native speakers of English) in a task dealing with modal verbs in a limited sentential context and with another task: a multiple choice test containing modal verbs in a free sentential context (Leech and Svartvik, 1975). The results of this investigation show context (limited / free) as a help for a better conceptual understanding, which make students more similar to native speakers in their command of modal verbs. Context is also considered as an important factor to gain knowledge on subjects cognitiveorganization, which is useful to teach this lexical group in a more effective way.

Published
2013
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16. BUTIMBA: Intensifying the Hunt for Child TB in Swaziland through Household Contact Tracing.

Author

Anna Maria Mandalakas, Katherine Ngo, Pilar Alonso Ustero, Rachel Golin, Florence Anabwani, Bulisile Mzileni, Welile Sikhondze, and Robert Stevens

Subjects
Medicine, Science
Abstract

Limited data exists to inform contact tracing guidelines in children and HIV-affected populations. We evaluated the yield and additionality of household contact and source case investigations in Swaziland, a TB/HIV high-burden setting, while prioritizing identification of childhood TB.In partnership with 7 local TB clinics, we implemented standardized contact tracing of index cases (IC) receiving TB treatment. Prioritizing child contacts and HIV-affected households, screening officers screened contacts for TB symptoms and to identify risk factors associated with TB. We ascertained factors moderating the yield of contact tracing and measured the impact of our program by additional notifications.From March 2013 to November 2015, 3,258 ICs (54% bacteriologically confirmed; 70% HIV-infected; 85% adults) were enrolled leading to evaluation of 12,175 contacts (median age 18 years, IQR 24-42; 45% children; 9% HIV-infected). Among contacts, 196 TB cases (56% bacteriologically confirmed) were diagnosed resulting in a program yield of 1.6% for all forms of TB. The number needed to screen (NNS) to identify a bacteriologically confirmed TB case or all forms TB case traced from a child IC

Published
2017
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17. Conocimiento de las competencias y metodología ECTS en alumnos de Magisterio de Educación Física de la Universidad de Huelva

Author

Pilar Alonso Martín

Subjects
Competencias transversales, Magisterio, EEES, competencias instrumentales, Education (General), L7-991
Abstract

La convergencia de las universidades españolas hacia un Espacio Común Europeo supone cambios metodológicos y por ello es necesario realizar análisis de las competencias que adquieren los alumnos en nuestras universidades. En este estudio se analizan y se comparan las competencias profesionales que deberían tener, a juicio de los alumnos de 1.º y 3.º curso de la titulación de Magisterio en la especialidad de Educación Física con las que aparecen en el "Libro Blanco". Los resultados muestran un perfil "clásico" del docente, con gran peso en competencias instrumentales; excesivamente centrado en su contexto próximo de trabajo y poco preocupado por el panorama cambiante de la educación.

Published
2009

18. Estudio comparativo de la satisfacción laboral en el personal de administración

Author

PILAR ALONSO MARTÍN

Subjects
Psychology, BF1-990
Abstract

Partiendo del Modelo de las carencias del trabajador (Herzberg, 1959) se plantea analizar si existen diferencias en la percepción de la satisfacción laboral. Es un estudio descritivo- transversal con una muestra de 80 sujetos pertenecientes al Personal de Administración y Servicios de un Universidad pública. Se ha utilizado el cuestionario de Satisfacción en el trabajo (Warr, Cokk y Wall, 1979). Los resultados muestran un nivel más alto de satisfacción laboral en las mujeres, los trabajadores de más edad y los con un mayor nivel de antigüedad y con un contrato de interino. Se concluye que son los factores externos, más concretamente, las relaciones sociales con los mandos superiores los que producen menor satisfacción en esta muestra, independientemente de las distintas variables medidas. Se hace necesario acciones concretas para mejorar la comunicación vertical.

Published
2008

19. THE STUDY OF MODAL VERBS FROM A PEDAGOGICAL PERSPECTIVE: AN ANALYSIS OF TEXTBOOKS AND GRAMMARS

Author

María Jesús Sánchez, Pilar Alonso, and Ramiro Durán

Subjects
Modal verbs, EFL classroom, grammars, textbooks, semantic values, pragmatic uses, Philology. Linguistics, P1-1091
Abstract

This paper shows how the indiscriminate combination of the form-function criterion in the traditional presentation of modal verbs brings more confusion than light to the subject due mostly to the fact that the grammatical simplicity of modal verbs clashes with their semantic complexity. In order to verify the treatment of modals in the EFL classroom, both a reduced but representative sample of textbooks and English grammar books will be analysed. Based on the findings of research conducted in this field, this article concludes that when studying modals in the EFL classroom the pragmatic uses of modal verbs should be primed over potential polysemic often indeterminate semantic values and/or grammatical criteria based on a higher or lower rank of graded modality.

Published
2007
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20. The lexico-structural/semantic progression in discourse topic construction: evidence from commento articles

Author

Pilar Alonso

Subjects
Discourse topic, global topic, local topic, comment article, Philology. Linguistics, P1-1091
Abstract

In this article, Seuren’s notion of mod-proposition is taken as point of departure to address the question of discourse topic. Seuren distinguishes between the classic notion of proposition (flat-propositions) and modulated propositions (mod-propositions), and assigns to the latter a topic-comment modulated structure which becomes essential to decide on the information structure of discourse, especially in terms of incrementation. Drawing from this propositional modulated status, different theoretical approaches to the notion of topic at sentence level are reviewed and special attention is paid to the syntactic functions identified by these theoreticians as predominantly topical. Then the empirical analysis of a small corpus of comment articles in English is used to classify the linguistic strategies employed in the construction of a global discourse topic; this procedure makes it possible to focus on those topics which gradually acquire global projection by re-use, in opposition to those pieces of information which are topical only at the local level. Based on this evidence, our research shows the linguistic mechanisms which allow for re-used topical information to gradually acquire subject status as discourse progresses and proposes thinking in terms of intermediate information structures as subsumers of local information and builders of global topics.

Published
2013

21. A cell cycle role for the epigenetic factor CTCF-L/BORIS.

Author

Manuel Rosa-Garrido, Laura Ceballos, Pilar Alonso-Lecue, Cristina Abraira, M Dolores Delgado, and Alberto Gandarillas

Subjects
Medicine, Science
Abstract

CTCF is a ubiquitous epigenetic regulator that has been proposed as a master keeper of chromatin organisation. CTCF-like, or BORIS, is thought to antagonise CTCF and has been found in normal testis, ovary and a large variety of tumour cells. The cellular function of BORIS remains intriguing although it might be involved in developmental reprogramming of gene expression patterns. We here unravel the expression of CTCF and BORIS proteins throughout human epidermis. While CTCF is widely distributed within the nucleus, BORIS is confined to the nucleolus and other euchromatin domains. Nascent RNA experiments in primary keratinocytes revealed that endogenous BORIS is present in active transcription sites. Interestingly, BORIS also localises to interphase centrosomes suggesting a role in the cell cycle. Blocking the cell cycle at S phase or mitosis, or causing DNA damage, produced a striking accumulation of BORIS. Consistently, ectopic expression of wild type or GFP- BORIS provoked a higher rate of S phase cells as well as genomic instability by mitosis failure. Furthermore, down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis.

Published
2012
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22. Relations between Mexico and the European Community

Author

Pilar Alonso

Subjects
Political science
Abstract

Mexico-EC bilateral relations must be considered within the general relation ECLatin America which -as the author remarks, do not appear among EC's preferential relations.Latin America can benefit from the Generalized Preference System which is not discriminatory, without reciprocity and generalized, but has some restrictions: for some products as textile, leather or oil. This affects some Latin American countries and specifically Mexico.Mexico initiates its relation with the EC in 1960; in 1975 both parts sign the Agreement on Economic and Trade Cooperation which has been substituted by the new General Agreement on Cooperation signed on April26, 1991. A new factor that will condition this relation is the Free Trade Agreement recently signed between USA, Canada and Mexico.

Published
1992

23. La visión del fenómeno bullying en alumnos del Curso de Aptitud Pedagógica en los años 2005/06 y 2006/07: semejanzas y diferencias

Author

Pilar Alonso-Martín

Subjects
bullying, Curso de Aptitud Pedagógica (CAP), formación, prevención, Education
Abstract

El objetivo del estudio es descubrir las creencias, conocimientos, actuaciones de intervención y prevención de los futuros profesores de secundaria sobre la violencia escolar. Es un estudio transversal con una población de 422 sujetos del Curso de Aptitud Pedagógica (CAP) durante los años 2005/06 y 2006/07. Se les aplicó un cuestionario basado en Ortega y Mora Merchán (2000) y en el Estudio del Defensor del Pueblo (1999). Los resultados obtenidos son similares a otros estudios (Informe del Defensor del Pueblo, 2007; Oñate y Piñuel, 2006; Ortega y Mora-Merchán, 2000; Pareja, 2002; Ramírez, 2006). Se detecta una necesidad de formación específica sobre el bullying

Published
2009
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24. La formación en competencias del profesorado de Magisterio en la especialidad de Educación Física

Author

Pilar Alonso Martín

Subjects
competencias transversales, Magisterio, Espacio Europeo de Educación Superior (EEES), competencias instrumentales, Education (General), L7-991
Abstract

La convergencia de las universidades españolas en un espacio común europeo supone cambios metodológicos y, por ello, es necesario realizar análisis de las competencias que adquieren los alumnos en nuestras universidades. En este estudio, se analizan y se comparan las competencias profesionales que, según su propio juicio, deberían tener los estudiantes de primer y tercer curso de la titulación de Magisterio en la especialidad de Educación Física de la Universidad de Huelva, de acuerdo con lo que aparece en el libro blanco. Los resultados muestran un perfil «clásico» del docente con gran peso en competencias instrumentales, excesivamente centrado en su contexto próximo de trabajo y poco preocupado por el panorama cambiante de la educación.

Published
2008
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25. Grammatical Conceptualization as a Poetic Strategy in E. E. Cummings' yes is a pleasant country

Author

Pilar Alonso Rodríguez

Subjects
conceptual projections, mental spaces, conceptual integration, blending, metaphor, knowledge domains, Language and Literature
Abstract

This article applies the theoretical principles of cognitive linguistics to E.E. Cummings’ poetic composition yes is a pleasant country. It combines the perspectives of conceptual metaphor theory, blending theory and the conceptual integration network model to show how grammatical conceptualization may be used as a poetic strategy, due to the semantic potential of grammar, which, as cognitive linguistics contends, is meaningful and symbolic in nature. The article also shows how CIN proves to be a valid model of analysis for poetic works given the highly concentrated and involved type of conceptualization they tend to use. Furthermore, it demonstrates that metaphorical mappings and blending are different and combinable mental operations which form a part of the intricate projections found in complex conceptual networks.

Published
2003
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26. The Role of Intersentential Connectives in Complex Narrative Discourse: Katherine Mansfield's 'The Garden Party'

Author

Pilar Alonso Rodríguez

Subjects
Language and Literature
Abstract

This paper explores the role of intersentential connectives in complex narrative discourse so as to investigate the applicability of recent findings in the literature to more complex data than that usually found in theoretical studies of the phenomenon. For this purpose the function of connectives in Katherine Mansfield’s short story “The Garden Party” will be analysed, concentrating mainly on the intersentential connectives AND and BUT which are unusually salient and recurrent throughout the text. The analysis shows that both connectives provide a means of attaining local and global cohesion, and, most important, they efficiently serve as explicit signals for the development and construction of all participants’ mental representations of the story.

Published
1996
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27. Development of a Robotic Platform with Order Management for the Catering Sector

Author

González, Sergio García, García, David Cruz, Marcos, Sergio Fernández, Correa, Isabel Pilar Alonso, Silva, Luis Augusto, González, Gabriel Villarrubia, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, de la Iglesia, Daniel H., editor, de Paz Santana, Juan F., editor, and López Rivero, Alfonso J., editor

Published
2023
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28. Application of Educational Support Through Disruptive Technology in Deaf Student Learning

Author

Borges, Lucas, de Moraes, André F., de M. Speroni, Rafael, Correa, Isabel Pilar Alonso, Silva, Luis Augusto, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, de la Iglesia, Daniel H., editor, de Paz Santana, Juan F., editor, and López Rivero, Alfonso J., editor

Published
2023
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32. Prevalencia de la enfermedad renal crónica y factores asociados en la población asistida en atención primaria de España: resultados del estudio IBERICAN

Author

García, Alfonso Barquilla, Rodríguez, Ángel Díaz, Cervantes, Carlos Escobar, Moreno, Francisco Javier Alonso, Roca, Gustavo Cristóbal Rodríguez, Martín, Jesús Vergara, Caro, José Luis Llisterri, Badimón, Juan José, García, José Polo, Padial, Luis Rodríguez, Prieto, Miguel Ángel, Pérez, Rafael Vidal, Sanjurjo, Sergio Cinza, Jiménez, Sonia Miravet, Zancada, Sonsoles Velilla, Téllez, Antonio López, de Los Ángeles Ortega Osuna, Maria, Cid, Cristóbal Prieto, Fajardo, María José Hidalgo, Serna, José Lorente, Requena, Ángel Domínguez, Cañizares, Ricardo Alberola, Peña, Manuel Ruiz, Collado, Filomena Herrero, Vázquez, Marcela Montes, Garrido, Rafael Ángel Carrascal, Lozano, María Reyes Herrera, Oliva, Beatriz Ortiz, Anguita, Francisco José, Ibáñez, Carmen Pérez, Rodríguez, Carlos Alberto Cabrera, Rodríguez, María José Cruz, Ruiz, Sandra Bonilla, González, Rocío Reina, Sánchez, Salomé Abad, Martínez, Inmaculada Santana, Jordán, Rafael Sánchez, Navas-Parejo, Juan María Ramos, Torres, José Manuel Ramírez, Poveda, José María Beltrán, Benayas, María Adoración de Cruz, Gil, Carmen Fernandez, Alcaine, Jon Iñaki Esturo, Quintero, Antonio Mora, Cepas, Fernando Leiva, Martín, José Luis Carrasco, Criado, Emilio García, Blanco, Mercedes Vázquez, Ortiz, Isabel Mora, Mendoza, Leovigildo Ginel, Rodríguez, Juan Carlos Aguirre, Rodríguez, Esperanza María Romero, Vázquez, José Acevedo, Ballesteros, Juan Gabriel García, Lara, María de La Paz Fernández, Moreno, Patricia Agüera, Maturana, Eduardo Paños, Expósito, Juan Manuel Ignacio, Peñas, Noelia Carrillo, Faya, Carmen María Abad, Duque, Ana Marina Almagro, Camisón, Rubén Torrescusa, Polo, Paloma Menéndez, García, Marina Peña, Fernández, Cristina López, Torres, Ascensión Estepa, Jansen, Miguel Gutiérrez, González, Esperanza Loizaga, Matarin, Lisardo García, Luna, Enrique José Gamero de, Rivero, Javier Benítez, Gómez González, María José, Montes, Carmen Gómez, Calvo, Eva Trillo, Calvo, Concepción Bayod, Natividad, Susana Larripa de La, Lambea, Germán Grasa, Marín, Emilio Jiménez, Gonzalvo, Ana Cristina Navarro, Martínez Barseló, Antonio Pablo, León, Irene Peña, Fernández, E. Lidia Gutiérrez, Mantecón, Fernando Andrés, Garrido, Ana Belén García, Escalante, Asunción Velez, Rentería, Luisa Alonso, Jiménez, Jesús Sainz, Alles, Guillermo Pombo, Garrote, Juan Antonio Divison, Sotodosos, Pedro Martínez, Fuster, Juan Antonio Vivancos, Palencia, María García, Moraleda, José Ambrosio Torres, Ballesteros, Sara González, Adrados, Ana Carmen Gil, Cabrera, Antonio González, Fernández, Miguel Ángel Babiano, García, Guillermo Rico, Criado-Álvarez, Juan José, Moreno, Pilar Torres, Aguirregaviria, Francisco Javier Arribas, Martínez, Alicia Sahuquillo, Béjar, Lourdes María Santos, Peralta, Miguel Laborda, Castro, Raúl Piedra, Altozano, Carlos Santos, Polo, Lucía González-Tarrio, Maresca, Pedro Valiente, Santana, Reinilda Mota, Ledesma, Noemi Elizabeth Terrero, Espada, Noelia Garrido, Calvi, Gabriela Delia Rosa Zambrana, Montero, Juan Lorenzo Gutiérrez, Gil, Juan Ignacio López, Ortega, María Dolores Fernández, Roncal, Miren Elizari, Serrano, María Ascensión López, Fuente, Nuria Esther Adrián de La, Larrea, Belén Angulo Fdez. de, Fernández, Naiara Cubelos, Gómez, Guiomar Luz Ferreiro, Rodríguez, Diana Gómez, Tuñón, Sonia María Andrés, González, María Ajenjo, Olea, Serafín de Abajo, Regueras, Juan José León, Nieto, César Manuel Gallego, Mallada, Delio Vázquez, García, Maria de La O Gutiérrez, Rodríguez, Pablo Baz, García, José Ignacio Ferradal, Martínez, Blanca Delia de Román, Pérez, Ana Arconada, Atoui, Omar Mahmoud, Bayón, Álvaro Morán, Olmo, María Teresa Armenteros del, Herreros, Fco. Javier García-Norro, Rodríguez, Enrique Méndez, Pineda, Diana María Narganes, Ainaga, Verónica Ortiz, Guevara, Milagros Sonlei Sánchez, Ferreiro, Laura Villota, Grande, M. Teresa Grande, Gracía, Francisco Vicente Martínez, García, María Dolores Moriano, Muñoz, Beatriz Jiménez, Marcelino, Gemma Rovira, Valverde, Diana Elizabeth Fernández, Bernadó, Roser Rodó, Lupiáñez, María Teresa Ortiz, Najih, Najlaa, Parra, José María Diéguez, Acebo, María Rosa Benedicto, Vicien, Mari Luz Bravo, Estella, Alberto Ramón León, Gómez, Juan Antonio Muñoz, Muntané, Alicia Mostazo, Abarca, Isabel Ortega, Fargas, Anna Gasol, Escudero, Brenda Elizabeth Riesgo, Riesgo, Susana Elizabeth, Castellvi, Edgar Zaballos, Sagarra, Celia Cols, Fernández, Marta Herranz, Presas, Josep Alins, Pérez, Idaira Damas, García, Rosa M. Alcolea, Collado, Inés Monte, Martínez, Roberto Genique, Villanueva, María José Guasch, Martínez, Teresa Rama, Pena, Lucio Pinto, Royo, Josefa María Panisello, Gil, Inés Gil, Montero, Alberto Calderón, Gómez, María del Mar Zamora, Cebrián, Elena Alarcón, Acin, María José Piñero, Sacristán, Celia Pecharromán, Vicente, M. Soledad Mayayo, Unanua, María Paz Pérez, Henrich, Nuria Marañón, Monreal, Saray Gómez, Pedro, Sonia Redondo de, Pozo, Blanca Sanz, Martínez, Irene Moreno, Uriarte, Beatriz López, Velasco, Carmelina Sanz, Aguirre, Amaya Gárriz, Teijido, Montserrat Rivera, Jaén, Germán Reviriego, Pascual-Salcedo, José Ignacio Aza, Gallego, Josefa Vázquez, Rodilla, Julia Caballer, Herrera, Aida, Martínez, Ezequiel Arranz, Calvo, Ana María Gómez, Oliva, Paula Morán, Béjar, María Milagros González, Hitos, Julio Antonio Heras, Vallejo, Olga García, Vargas, Manuel de Jesús Frías, Boguerin, María Jesús Castillejo, Lerin, Aurora García, Tablado, Miguel Ángel María, García, Elena Concepción García, Acero, Leticia de Miguel, Oñate, Carmen Zárate, Apoita, Aránzazu Barranco, Belloso, María Ester Montes, Velasco, Ana María Huertas, Jiménez, Rafael Sáez, Pascual, Julia Natividad García, Zuluaga, María Clemencia Zuluaga, Perez, María Cruz Díez, García, Antonio Ruiz, Jelsbak, Cristina Murillo, Oria, Virginia Lasso, Gamarra, Amelia González, Fuster, Vicente Pascual, Bort, María Dolores Aicart, Gómez, Natividad Vázquez, Gasco, Carlos Lluna, Barber, Teresa Amoros, Cano, Pedro Antonio Medina, Moncho, Miguel Monteagudo, Muñoz, María Jesús Larré, Hernández, Raquel Navarro, Egea, Francisco José Martínez, Tramontano, Antonio, Royo, Marta Ferrer, Saura, Belén Persiva, Torres, Juan A. Contreras, Moliner, José María Tirado, Penalba, Alejandro Salanova, Alberola, Ariadna Cucó, Ros, Fernando María Navarro I., Llicer, Enrique Beltrán, Novás, Ana Seoane, Valls, Inmaculada Martín, Mahiques, Gracia Verdú, Forcada, Enrique Peña, Gómez, Nieves Aguilar, García, Francisco Javier Sanz, Bueso, M. Dolores Paradís, Romero, María Eugenia Alegre, Camus, Antonio Francés, Peinado, María Amparo Antón, Santos, Rosa Latorre, Marín, María Asunción Palomar, García, María Carmen Botella, Fresquet, Eva Sánchez, Paños, Pedro Sala, Ruiz, Tomás Sánchez, Valero, Rosa Ana Valero, Vicente, María Seoane, Llinares, Magdalena Martín, Alegre, Antonio Masiá, Verdú, Irene Lluch, Carratala, Vicente Pallares, Roca, Francisco Valls, Pérez, Rafael Manuel Micó, García, Jacinto Espinosa, Romo, José Ignacio Prieto, Fernández, Leandro Fernández, Sierratapia, Javier, Regidor, Nieves Moreno, Sánchez, Francisco Javier Zaballos, Moreno, Ana Moreno, Barrera, Francisco Carramiñana, Vázquez, Juan José Torres, Samino, María José Gamero, Rodríguez, Miguel Ángel de Santiago, Martínez, Pablo Rafael Gómez, Becerra, Antonio Carlos Elías, Olivera, Javier Soto, Cambero, Víctor, Ávila, Julián Domínguez, Fuentes, Andrés Simón, Jiménez, Jorge Manuel de Nicolás, Fraile, Dimas Igual, Barco, Guadalupe Nieto, Ramos, Ignacio Araujo, Berrocal, María Luz Serrano, Ramírez, Francisco Buitrago, Marcos, Minerva Gallego, González, Félix Suárez, Carrasco, Victoriano Chavero, Peguero, Francisco Guerra, Vega, Francisco Javier Sánchez, Mas, Manuel Tejero, Donoso, Alba Palmerín, Yedro, Miguel Turégano, Rojas, María Beatriz Esteban, Moreno, Fátima Cabezudo, Saldaña, Nawson Elver Quevedo, Fenés, María del Mar García, Florencio, Timotea Garrote, Toro, José María Fernández, Rañal, Alejandra Rey, Río, Elena García del, Pol, Enrique Nieto, Fernández, Julio Álvarez, Álvarez, Pilar Alonso, Gómez, María Luisa Jorge, Guerrero, Antonio Calvo, Colomina, Isabel Celemín, Casal, Lucía Barreiro, Moreno, Juana Fernández, Martínez, María Angelines Carballal, Rodríguez, Nabor Díaz, Paredes, Carlos Moral, García, Dolores Recarey, Mato, Fco. Javier Iglesias, Ulloa, Antonio Fouz, González, Amparo Fidalgo, Parada, Noelia Dios, Sabarís, Patricia Conde, Pérez, Ana Isabel Rodríguez, Palacio, Ana Inés García, Varela, Víctor Julio Quesada, Iglesias, Lidia Romero, Llerena, Ángel Lado, Rodríguez, Carmen Lires, Diaz, María Luisa Carretero, Arias, José Carreira, Camino, Jose Luis Vázquez, Penas, María del Carmen Torreiro, Freire, Sandra Yáñez, Aldana, Daniel Rey, Díaz, Carlos Piñeiro, Romanos, Fernando García, González, Antonia Moreno, Sastre, María Lara Amengual, Palli, Susana Martínez, Bauza, José Alfonso Ramón, Bolinches, José Ortiz, Fernández, Carmen Fernández, Vázquez, María Isabel Orlandis, Mezquita, Ana Sanchís, Aramburu, Fernando Unceta, Morant, Juan Fernando Peiró, Amengual, Ana Moyá, García, Isidro Godoy, Sevillano, Fernando Rubio, González, María Isabel González, Souto, Marta Pérez, Contreras, Raquel de León, González, Sara Isabel Almeida, Diez, Irene Almería, Sánchez, Virginia María Mirabal, Lavado, Francisco José Escobar, Pérez, Yoel Anta, Hernández, Nayra Sánchez, Jerez, Juan Luis Alonso, Koch, Ricardo, Mendoza, Nayra Ramírez, Hernández, Héctor Suárez, Escobar, Francisco Jesús Morales, Zancada, Sonsoles María Velilla, Sabarís, Rafael Crespo, Jiménez, Óscar Fernando Isaula, Puga, Jesús Manuel González, Ávila, Jorge Antonio Benaín, González, Óscar del Toro, Íñigo, Laura Sánchez, Pérez, Inés Sanz, Nubla, José Félix Zuazagoitia, Ituiño, Ana Echebarría, Tris, Gregorio Mediavilla, Bosch, María Carmen Noriega, González, Esther, Macho, María Luisa Ruiz, Olmo, Ruth Sendino del, Prado, Asunción Olagorta de, Muguerza, Ana López de Viñaspre, Iriso, Jesús Iturralde, Martínez, María José Pérez, Carbonell, Ana Piera, Fernández, Margarita Alonso, Cuadrado, María Montserrat Rueda, Rodríguez, Rodrigo Abad, Cabo, José Miguel Álvarez, Rodríguez, Rubén Sánchez, Cabo, Eva María Cano, Secin, Anny Romero, Díaz, Miguel Ángel Prieto, Fernández, Juan Jesús García, Bueno, Vicente Llorca, Pérez, Ana María Ballesteros, López, Domingo J. Rubira, Franco, María Dolores Esteve, Pablo, Elena Sánchez, López, María Teresa Palacios, Meroño, Juan Castillo, Martínez, José María Lobo, Martínez, Isabel María Peral, Carrasco, J. Eduardo Carrasco, González, Armando Santo, Llisterri, José Luis, Micó-Pérez, Rafael Manuel, Velilla-Zancada, Sonsoles, Rodríguez-Roca, Gustavo Cristóbal, Prieto-Díaz, Miguel Ángel, Martín-Sánchez, Vicente, Barquilla, Alfonso, Polo-García, José, Segura-Fragoso, Antonio, and Cinza-Sanjurjo, Sergio

Published
2021
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33. Evolution of Salmonella spp. isolated compared to those of Campylobacter spp. in faecal samples for 12 years.

Author

de Malet Pintos-Fonseca, Ana, Maseda, Susana Orol, Lopez, Isabel Lopez, Ferreiro, Rebeca Rodil, de Alegría Puig, Carlos Ruiz, and Garcia, Pilar Alonso

Subjects
CAMPYLOBACTER infections, GRAM-negative bacterial diseases, SALMONELLA diseases, ENTEROBACTERIACEAE diseases, PUBLIC health
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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36. El perfil del buen docente universitario desde una perspectiva del alumnado

Author

Pilar Alonso Martín

Subjects
Enseñanza superior, Personal docente, Valoración, Estudiante universitario, Education (General), L7-991
Abstract

Resumen La adaptación al Espacio Europeo de Educación Superior (EEES) está suponiendo un gran cambio en el rol del docente universitario. Este estudio aporta información sobre la importancia que otorgan los estudiantes de tercer curso de las titulaciones de Magisterio (primaria), Educación Social, Psicología y Psicopedagogía a las cualidades personales, profesionales y metodología que consideran que debe tener un buen profesor de universidad. Para ello se pasó un cuestionario a 269 estudiantes pertenecientes a las cuatro titulaciones de la Facultad de Ciencias de la Educación. Los resultados muestran que los alumnos valoran especialmente que el profesor universitario sea respetuoso, claro en las explicaciones, con dominio de la materia, buen comunicador, que utilice ejemplos prácticos y reales, prepare las clases, con capacidad de escucha y empatía. Existen diferencias significativas, a nivel estadístico, entre las valoraciones realizadas en función del sexo y de la titulación a la que pertenecen. El profesorado universitario debe tener una formación psicopedagógica que le ayude a ser un buen docente y más en el caso de facultades donde se formarán a futuros maestros y aquellas profesiones relacionadas con el aprendizaje.

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37. Species and biotypes of Streptococcus bovis causing infective endocarditis

Author

Eva Romay, Guillermo Cuervo, Fernando García-Garrote, Roman Pallares, Mª José García-Pais, Blanca Ayuso, Mª Pilar Alonso, Inma Grau, José Francisco García-Rodríguez, Juan Corredoira, Dàmaris Berbel, and Román Rabuñal

Subjects
Microbiology (medical), education.field_of_study, biology, business.industry, Incidence (epidemiology), Population, Retrospective cohort study, General Medicine, medicine.disease, Streptococcus bovis, biology.organism_classification, Microbiology, Infective endocarditis, parasitic diseases, medicine, Streptococcus gallolyticus, education, business
Abstract

Introduction Streptococcus bovis/equinus complex (SBEC) is a major cause of infective endocarditis (IE), although its incidence varies greatly depending on the geographical area. The characteristics of IE caused by Streptococcus gallolyticus susp. gallolyticus are well known; there are hardly any descriptions of IE caused by other species or biotypes. Methods Retrospective cohort study, from 1990 to 2019, of all SBEC IE in adults in three Spanish hospitals, Lugo (LH), Barcelona (BH) and Ferrol (FH) where the population is mainly rural, urban and mixed, respectively. The incidence of IE was analyzed in 3 areas. Clinical characteristics of IE (277 cases, 258 biotyped) were compared according to SBEC species and biotypes. Results There are significant differences between the incidence of SBEC IE in HL (27.9/106) vs. HF and HB (8.8 and 7,1, respectively, p Conclusions IE due to SBEC has geographical variations in incidence and different clinical characteristics among biotypes. The association with CRC was high.

Published
2023
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40. Tree-size heterogeneity modulates the forest age-dependent carbon density in biomass and top soil stocks on Mediterranean woodlands

Author

Héctor Hernández-Alonso, Jaime Madrigal-González, Lorién Tornos-Estupiña, Alberto Santiago-Rodríguez, Pilar Alonso-Rojo, Albert Morera-Beita, and Fernando Silla

Subjects
Soil Science, Plant Science
Abstract

Aims Carbon accumulation in terrestrial ecosystems is inherent to the vegetation development and ageing process. Primary productivity synthetize biomass which is constantly incorporated to soil. Vegetation community composition, and other ecological drivers, are known to mediate biomass production. However, links between forest developmental stage and ecological drivers of carbon stocks are unexplored. We address this topic under the prediction that species-rich and uneven-sized forests can improve carbon storage potential in biomass and topsoil fraction across its development. Methods The study was carried in forest stands growing under Mediterranean conditions in Central Spain. Carbon content in both above- and below-ground tree biomass and in topsoil organic matter (0–40 cm) was measured in 30 sampling plots of variable size (900–3000 m2). We also assessed Shannon species diversity index, Gini tree-size inequality index and forest developmental stage using dendrochronological procedures to derive the mean age of the oldest trees. First-order interaction terms between diversity factors and forest age were regressed against carbon density in compartment-independent regressions. Results Forest-age and tree-size heterogeneity coupling was the main factor driving carbon density of both compartments. The interaction showed that woodlands maximize density in aged forests composed by uneven-sized trees. Models gave not support to consider species diversity as a mediator of carbon stocks. Conclusion Our results shed light on how tree-size heterogeneity can regulate the temporal dimension of forest ageing to rise the carbon storage potential. Mature forests in semi-arid environments cannot store carbon due to their intrinsic ontogeny, they need to grow structurally diverse.

Published
2023
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43. Espondilodiscitis por Streptococcus suis: 2 nuevos casos y revisión bibliográfica

Author

Iria Iñiguez-Vázquez, Fernando García-Garrote, Juan Corredoira-Sánchez, Pablo Ventura-Valcárcel, Eva-María Romay-Lema, Ramón Rabuñal-Rey, María-José García-Pais, and María Pilar Alonso

Subjects
0301 basic medicine, Microbiology (medical), Spondylodiscitis, biology, business.industry, 030106 microbiology, Streptococcus suis, medicine.disease, biology.organism_classification, 03 medical and health sciences, 0302 clinical medicine, medicine, 030212 general & internal medicine, business, Humanities
Abstract

Resumen Introduccion La infeccion por Streptococcus suis (S. suis) es una zoonosis poco descrita en nuestro pais, que se relaciona con la exposicion al ganado porcino o su carne. La forma de presentacion mas frecuente es la meningitis, mientras que la afectacion de la columna vertebral es rara. Metodos Presentamos 2 casos de infeccion por S. suis y realizamos una revision sistematica de los trabajos publicados sobre espondilodiscitis por S. suis entre enero de 1994 y mayo de 2020 con el objetivo de definir las caracteristicas clinicas, sus factores predisponentes y su evolucion. Resultados Se describen 17 casos, el 76,5% varones con una edad media de 57,6 anos, generalmente sin enfermedad de base asociada. El enolismo fue un factor presente en casi el 17,6% de los pacientes. Un 70,6% presentaron exposicion a ganado porcino o su carne y un 20% heridas en manos. La duracion media de los sintomas fue de 10,2 dias y el segmento mas afectado fue el lumbar. Un 70,6% curso con meningitis. Todos se trataron con betalactamicos con una duracion media de 53,2 dias. Hubo una recidiva y ninguno fallecio. Conclusion Existen pocos casos de espondilodiscitis por S. suis en la literatura. Cuando ocurre, se asocia a otro tipo de infeccion en la mayoria de los casos. Presentan buena respuesta al tratamiento medico y buen pronostico.

Published
2022
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45. Research trends in Economic Geography : Bibliometric study of the Web of Science (1920-2020)

Author

Pilar Alonso Logroño, Nuria Bautista-Puig, and Ministerio de Ciencia e Innovación (MICIN). España

Subjects
Bibliometric analysis, Geografía Económica, Economic geography, Análisis bibliométrico, Web of Science, General Medicine, Topic modelling
Abstract

Una de las primeras tareas para abordar cualquier trabajo académico es revisar las publicaciones llevadas a cabo sobre el tema. En este artículo se presenta una metodología que permite analizar las tendencias científicas en una disciplina a través de un análisis bibliométrico. En concreto, se examina su utilidad para estudiar los trabajos en el campo de la Geografía Económica; para ello se ha elegido como base de datos para su análisis la Web of Science (WoS). Con un conjunto de 4,307 publicaciones se analizan varios indicadores bibliométricos como la evolución de la producción científica, los agentes involucrados (países y organizaciones) y temas abordados, con el objetivo de ver la trayectoria del volumen de trabajos y las especializaciones temáticas de la Geografía Económica desde 1920 a la actualidad. One of the first tasks to tackle any scientific publication is to review all the scientific literature on the subject. This article presents a methodology that allows analyzing scientific trends in a discipline through a bibliometric analysis. Specifically, the field of Economic Geography is used as a case study, Web of Science (WoS) has been chosen as the database for this analysis. With a set of 4,307 publications, various bibliometric indicators are analyzed, such as the evolution of scientific production, the agents involved (countries and organizations) and topics addressed, in order to see the evolution of the scientific output and the thematic specializations of Economic Geography from 1920 to the present. Se agradece el apoyo de financiación del proyecto “Innovación Socioeconómica y estrategias post-pandemia en los espacios metropolitanos de Valencia y Zaragoza” (PID2020-112734RB-C31), financiado por MCIN/ AEI/10.13039/501100011033/.

Published
2022
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46. Conservación de vidrieras históricas con tecnologías láser: el reto de limitar la acumulación de calor

Author

Evan Maina Maingi, María Pilar Alonso, Luis Alberto Angurel, Md Ashiqur Rahman, Rémy Chapoulie, Stéphan Dubernet, Germán Francisco de la Fuente, European Commission, Gobierno de Aragón, Universidad de Zaragoza, Consejo Superior de Investigaciones Científicas (España), and Universidad de Burgos

Subjects
Ultra-short pulsed-laser, Mechanics of Materials, Vidrieras, Acumulación de calor, Cultural heritage, Ceramics and Composites, Heat accumulation, Conservation, Industrial and Manufacturing Engineering, Láseres de pulsos ultracortos, Stained-glass
Abstract

[EN] Stained-glass windows form an important part of cultural heritage. Short pulse lasers open new opportunities for safe decontamination. In this work, and for the first time, the interaction of sub-nanosecond and femtosecond pulsed lasers with some contemporary stained-glasses has been analyzed exploring their applicability to safely clean stained-glass windows. The results show that, in these materials, damage can be induced using energy levels below damage thresholds due to the heat accumulation in the coating layer that is being eliminated. The latter generates significant thermal stresses on the glass volume, which induce crack formation. In consequence, in order to apply safe stained-glass cleaning protocols, laser parameters have to be selected to control the temperature increase within this layer. To achieve the latter goal, two alternative irradiation procedures were explored in this work. As a first option, a reduction of the effective pulse repetition frequency to values lower than 20 kHz was applied. A second alternative was used for lasers with pulse repetition rates in the hundreds of kHz. In this case, the burst mode was employed controlling the number of pulses emitted and combined with an adequate time lapse selection between two consecutive burst runs. A proof of concept demonstration was carried out on a stained-glass sample from the Cathedral of Cuenca, dated at the end of the XV century., [ES] Las vidrieras constituyen un elemento esencial de nuestro patrimonio cultural. Los láseres de pulsos ultracortos ofrecen nuevas oportunidades para desarrollar procesos de restauración seguros. En este trabajo, por primera vez, se estudia la interacción de láseres pulsados emitiendo pulsos en el rango de los subnanosegundos y femtosegundos con piezas de vidrieras contemporáneas, con el fin de explorar la posibilidad de desarrollar procesos seguros de restauración de vidrieras. Los resultados muestran que, en estos materiales, incluso trabajando con niveles de energía por debajo de los umbrales de daño, se puede generar deterioro por la acumulación de calor generada en la capa que se está eliminando, lo cual puede generar niveles de tensiones térmicas que provocan la ruptura del vidrio. Por tanto, para desarrollar protocolos de limpieza seguros, los parámetros de procesado deben escogerse de tal manera que se minimice la temperatura que se alcanza en esta capa. Se han explorado dos alternativas. Una es reducir la frecuencia de trabajo hasta valores por debajo de los 20 kHz. En el caso de láseres que trabajen a frecuencias más elevadas, la alternativa es trabajar en modo burst, limitando el número de pulsos en cada serie y estableciendo tiempos de espera entre dos series. Estas ideas se han aplicado sobre una pieza de vidriera de la Catedral de Cuenca de finales del siglo XV., This work was supported by European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement N.° 766311. Partial support is obtained from Gobierno de Aragón “Construyendo Europa desde Aragón” (research group T54_20R). The use of Servicio General de Apoyo a la Investigación at the University of Zaragoza is acknowledged. This work has been performed in the framework of the Unidad Asociada de I+D+I al CSIC “Vidrio y Materiales del Patrimonio Cultural (VIMPAC)”, by INMA (CSIC-University of Zaragoza) and University of Burgos.

Published
2022
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47. Water Erosion Risk Analysis in the Arribes del Duero Natural Park (Spain) Using RUSLE and GIS Techniques

Author

Leticia Merchán, Antonio Miguel Martínez-Graña, Pilar Alonso Rojo, and Marco Criado

Subjects
Renewable Energy, Sustainability and the Environment, Geography, Planning and Development, Building and Construction, water erosion, soil loss, RUSLE, GIS, Arribes del Duero, Management, Monitoring, Policy and Law
Abstract

Nowadays, soil erosion is a global problem of great environmental and social concern, affecting natural resources, natural spaces and agricultural production. Therefore, it is necessary to carry out an erosion risk analysis to estimate the amount of soil lost, as well as to establish possible conservation practices to mitigate this loss. One way of doing this is through the integration of empirical equations such as RUSLE and GIS techniques, giving rise to a mapping of potential and actual erosion, considering the factors that make up this equation. The results obtained indicate that the areas with extreme erosion levels in Arribes del Duero, that is, with the greatest losses (greater than 200 Tm/ha/year), correspond to areas with steep slopes, poorly developed soils such as Leptosols and Regosols and vegetation with little or no vegetation cover. On the other hand, areas with stable levels of erosion (up to 10 Tm/ha/year) are found in flat areas, with more developed soils, such as Alisols and Luvisols, and vegetation with a higher density and herbaceous cover. Finally, it is concluded that the integration of GIS techniques with parametric equations constitutes a simple and economic tool for estimating these losses and, together with land use, allows different mitigation measures to be established, which, in our study area, focus on reducing the length and gradient of the slope, such as contour cultivation, construction of terraces and “bancales”.

Published
2023
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48. Ultra-short pulse laser cleaning of contaminated pleistocene bone: A comprehensive study on the influence of pulse duration and wavelength

Author

Md. Ashiqur Rahman, Germán F. de la Fuente, José Miguel Carretero, Mª Pilar Alonso Abad, Rodrigo Alonso Alcalde, Rémy Chapoulie, Nick Schiavon, Luis A. Angurel, and European Commission

Subjects
Femtosecond laser, Archeology, Archaeological bone, Sub-nanosecond laser, Sima de los Huesos, Materials Science (miscellaneous), Wavelength, Cleaning, Pulse duration, Conservation
Abstract

This article belongs to the Special Issue Cleaning Strategies for Cultural Heritage., The impact of wavelength and pulse duration in laser cleaning of hard blackish contaminants crust from archaeologically significant Pleistocene bone is investigated in this research. The objective is to determine the practical cleaning procedures and identify adequate laser parameters for cleaning archaeological bone from Sima de los Huesos (Spain) based on conservation and restoration perspectives. Bone surface cleaning was performed utilizing two Q-switched Nd:YAG lasers: sub-nanosecond pulsed lasers with emission wavelengths at 355 nm and 1064 nm, respectively, and a Yb:KGW femtosecond pulsed laser with an emission wavelength in the third harmonic at 343 nm. In all experiments, the laser beam scanning mode was applied to measure cleaning efficiency in removing contaminants and degradation products while assessing the underlying substrate surface damage. Several properties, including wavelength-dependent absorption, pulse repetition rate, and thermal properties of the material, are analyzed when evaluating the ability of these lasers to boost the cleaning efficiency of the deteriorated bone surface. Bone surface morphology and composition were studied and compared before and after laser irradiation, using Optical Microscopy, Scanning Electron Microscopy with Energy Dispersive X-ray Spectrometry (SEM-EDS), Fourier Transform Infrared Spectroscopy (FTIR), and X-ray Photoelectron Spectroscopy (XPS) characterization methods. The results indicate that 238-femtosecond UV laser irradiation with 2.37 TWcm−2 is significantly safer and more efficient toward surface contaminant desorption than sub-nanosecond laser irradiation. The results herein presented suggest that these types of fs lasers may be considered for realistic laser conservation of valuable historic and archaeological museum artifacts., This research was funded by the H2020-MSCA-ITN-EJD/ED-ARCHMAT action funding under the Marie Skłodowska-Curie grant agreement, No 766311.

Published
2023

49. UV femtosecond laser cleaning of encrusted historical stained-glasses

Author

Evan Maina Maingi, María Pilar Alonso Abad, Germán F. de la Fuente, Stéphan Dubernet, Yannick Lefrais, Rémy Chapoulie, Elodie Vally, and Luis A. Angurel

Subjects
Ultra-short pulse lasers, Archeology, Chemistry (miscellaneous), Laser cleaning, Materials Science (miscellaneous), Cultural heritage, Conservation, General Economics, Econometrics and Finance, Spectroscopy, Stained-glass
Abstract

Laser irradiation enables the removal of unwanted surface deposits from different materials in a safe and controllable manner. Laser parameters should be carefully selected to achieve the removal of the target contaminants without inducing damage to the substrate. Ultra-short pulse lasers have opened new opportunities for safe and controlled decontamination of cultural heritage materials because the thickness of material that is affected by the laser is limited. In this study, an ultraviolet femtosecond pulsed laser was used for the removal of unwanted encrustation formed on the surface of an historical colourless stained-glass sample from the Cuenca Cathedral in Spain. One of the sides of this glass exhibits a reddish-brown grisaille that also has to be preserved. A laser cleaning process has been designed to avoid heat accumulation while controlling the thickness of ablated material. In this context, a multi-step process was selected in order to be able to eliminate, in a controlled way, the crust layer without damaging the grisaille layer, or the glass substrate. In this case, laser irradiation in beam scanning mode with a pulse repetition frequency of 10kHz proved to be effective for the safe cleaning of the glass. The latter was analysed before and after laser cleaning by optical and confocal microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray fluorescence, and Raman spectroscopy, confirming that the crust layer was effectively eliminated without damaging the surface.

Published
2023

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