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698 results on '"Pijnenburg, Yolande a.L."'

4. Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood

Author

Ferrari, Raffaele, Hernandez, Dena G., Nalls, Michael A., Rohrer, Jonathan D., Ramasamy, Adaikalavan, Kwok, John B.J., Dobson-Stone, Carol, Brooks, William S., Schofield, Peter R., Halliday, Glenda M., Hodges, John R., Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Haan, Eric, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Cruchaga, Carlos, Cairns, Nigel J., Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Waldö, Maria Landqvist, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian R.A., Hsiung, Ging-Yuek R., Mann, David M.A., Grafman, Jordan, Morris, Christopher M., Attems, Johannes, Griffiths, Timothy D., McKeith, Ian G., Thomas, Alan J., Pietrini, P., Huey, Edward D., Wassermann, Eric M., Baborie, Atik, Jaros, Evelyn, Tierney, Michael C., Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Diehl-Schmid, Janine, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Pinessi, Lorenzo, Rogaeva, Ekaterina, St. George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James B., Schlachetzki, Johannes C.M., Uphill, James, Collinge, John, Mead, Simon, Danek, Adrian, Van Deerlin, Vivianna M., Grossman, Murray, Trojanowski, John Q., van der Zee, Julie, Deschamps, William, Van Langenhove, Tim, Cruts, Marc, Van Broeckhoven, Christine, Cappa, Stefano F., Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E., Hjermind, Lena E., Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Gasparoni, Gilles, Pichler, Sabrina, Gu, Wei, Rossor, Martin N., Fox, Nick C., Warren, Jason D., Spillantini, Maria Grazia, Morris, Huw R., Rizzu, Patrizia, Heutink, Peter, Snowden, Julie S., Rollinson, Sara, Richardson, Anna, Gerhard, Alexander, Bruni, Amalia C., Maletta, Raffaele, Frangipane, Francesca, Cupidi, Chiara, Bernardi, Livia, Anfossi, Maria, Gallo, Maura, Conidi, Maria Elena, Smirne, Nicoletta, Rademakers, Rosa, Baker, Matt, Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Knopman, David, Josephs, Keith A., Boeve, Bradley F., Parisi, Joseph E., Seeley, William W., Miller, Bruce L., Karydas, Anna M., Rosen, Howard, van Swieten, John C., Dopper, Elise G.P., Seelaar, Harro, Pijnenburg, Yolande A.L., Scheltens, Philip, Logroscino, Giancarlo, Capozzo, Rosa, Novelli, Valeria, Puca, Annibale A., Franceschi, Massimo, Postiglione, Alfredo, Milan, Graziella, Sorrentino, Paolo, Kristiansen, Mark, Chiang, Huei-Hsin, Graff, Caroline, Pasquier, Florence, Rollin, Adeline, Deramecourt, Vincent, Lebert, Florence, Kapogiannis, Dimitrios, Ferrucci, Luigi, Pickering-Brown, Stuart, Singleton, Andrew B., Hardy, John, Momeni, Parastoo, Ge, Yi-Jun, Ou, Ya-Nan, Deng, Yue-Ting, Wu, Bang-Sheng, Yang, Liu, Zhang, Ya-Ru, Chen, Shi-Dong, Huang, Yu-Yuan, Dong, Qiang, Tan, Lan, and Yu, Jin-Tai

Published
2023
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6. The Benson Complex Figure Test detects deficits in visuoconstruction and visual memory in symptomatic familial frontotemporal dementia: A GENFI study

Author

Jiskoot, Lize C., Russell, Lucy L., Peakman, Georgia, Convery, Rhian S., Greaves, Caroline V., Bocchetta, Martina, Poos, Jackie M., Seelaar, Harro, Giannini, Lucia A.A., van Swieten, John C., van Minkelen, Rick, Pijnenburg, Yolande A.L., Rowe, James B., Borroni, Barbara, Galimberti, Daniela, Masellis, Mario, Tartaglia, Carmela, Finger, Elizabeth, Butler, Chris R., Graff, Caroline, Laforce, Robert, Jr, Sanchez-Valle, Raquel, de Mendonça, Alexandre, Moreno, Fermin, Synofzik, Matthis, Vandenberghe, Rik, Ducharme, Simon, le Ber, Isabelle, Levin, Johannes, Otto, Markus, Pasquier, Florence, Santana, Isabel, Cash, David M., Thomas, David, and Rohrer, Jonathan D.

Published
2023
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7. Spatial distributions of white matter hyperintensities on brain MRI: A pooled analysis of individual participant data from 11 memory clinic cohorts

Author

Coenen, Mirthe, Biessels, Geert Jan, DeCarli, Charles, Fletcher, Evan F., Maillard, Pauline M., Barkhof, Frederik, Barnes, Josephine, Benke, Thomas, Boomsma, Jooske M.F., P.L.H. Chen, Christopher, Dal-Bianco, Peter, Dewenter, Anna, Duering, Marco, Enzinger, Christian, Ewers, Michael, Exalto, Lieza G., Franzmeier, Nicolai, Groeneveld, Onno, Hilal, Saima, Hofer, Edith, Koek, Huiberdina L., Maier, Andrea B., McCreary, Cheryl R., Papma, Janne M., Paterson, Ross W., Pijnenburg, Yolande A.L., Rubinski, Anna, Schmidt, Reinhold, Schott, Jonathan M., Slattery, Catherine F., Smith, Eric E., Sudre, Carole H., Steketee, Rebecca M.E., van den Berg, Esther, van der Flier, Wiesje M., Venketasubramanian, Narayanaswamy, Vernooij, Meike W., Wolters, Frank J., Xin, Xu, Biesbroek, J. Matthijs, and Kuijf, Hugo J.

Published
2023
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9. Everyday functioning in young onset dementia: differences in diagnostic groups independent of disease stage.

Author

Weltings, Emma, Postema, Merel C., Tewolde, Mukrabe E., Duits, Flora H., Lemstra, Afina Willemina, van der Flier, Wiesje M., Pijnenburg, Yolande A.L., and Sikkes, Sietske A.M

Abstract

Background: Young onset dementia (YOD) is characterized by an atypical clinical manifestation, and it is unclear to what extent impairments in everyday functioning are part of this manifestation. This study aims to describe the prevalence and differences of difficulties in instrumental activities of daily living (IADL) in YOD. Methods: In this cross‐sectional study, 394 subjects with sporadic YOD (onset<65 years,mean(M)age 58.4±standard deviation(SD)4.4 years;49.2% female) were included from the Amsterdam Dementia Cohort (ADC). Diagnoses were established in multidisciplinary consensus meetings according to disease‐specific diagnostic criteria. Everyday functioning was assessed using the proxy‐based Amsterdam IADL Questionnaire (A‐IADL‐Q). Linear regression analyses were performed to assess differences between YOD subtypes in IADL with group (YOD subtypes with AD as reference group) and IADL as outcome, adjusted for age, sex, education and disease severity (Mini Mental State Examination). A bifactor analysis was performed to identify item clusters and explore differences between groups (using linear regression). Results: The majority of sporadic YOD were diagnosed with Alzheimer's Disease (AD,n = 291(74%)), followed by Dementia with Lewy Bodies (DLB,n = 25(6%)), behavioral variant Frontotemporal Dementia (bvFTD,n = 49(12%)), Primary Progressive Aphasia (PPA,n = 20(5%)) and semantic variant Primary Progressive Aphasia (svPPA,n = 9(2%)). Most IADL difficulties were observed in DLB ((M) A‐IADL‐Q 41.8±(SD)7.78, reflecting moderate problems), and the fewest in PPA ((M)59.9±(SD)6.62, reflecting no problems)(Figure 1). When compared to AD (reference group), multiple linear regression analysis confirmed lower IADL scores for DLB (β = ‐6.37, SE = 1.63,p≤0.001), and higher for PPA (β = 10.29, SE = 1.76, p≤0.001), and svPPA (β = 6.83, SE = 2.61,p = 0.009), after adjustment for all covariates and confirmed in post‐hoc testing (Table 1). The bifactor analysis showed good reliability of the A‐IADL‐Q (Omega (ω_total) = 0.833), suggesting the presence of an underlying unimodal construct. Additional item clusters (Table 1) showed differences across groups, e.g. bvFTD showed more impairments in household activities compared to AD (β[95%CI] = ‐3.12 [‐5.64 – ‐0.61]). Further activity‐level differences can be found in Figure 2. Conclusions: Our results suggest that YOD‐subtypes differ in everyday functioning difficulties, independent of disease stage. These findings contribute to the understanding of everyday functioning difficulties in YOD, ultimately contributing to earlier recognition of the disease and personalized care. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Comparing and linking the Mini-Mental State Examination and Montreal Cognitive Assessment in the Amsterdam Dementia Cohort.

Author

Dubbelman, Mark A., van de Beek, Marleen, van Gils, Aniek M., Leeuwis, Anna E., van der Vlies, Annelies E., Pijnenburg, Yolande A.L., Ponds, Rudolf, Sikkes, Sietske A.M., and van der Flier, Wiesje M.

Subjects
MONTREAL Cognitive Assessment, MILD cognitive impairment, MEDICAL scientists, ALZHEIMER'S disease, MEDICAL screening, MINI-Mental State Examination
Abstract

Objectives: We aimed to compare and link the total scores of the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), two common global cognitive screeners. Methods: 2,325 memory clinic patients (63.2 ± 8.6 years; 43% female) with a variety of diagnoses, including subjective cognitive decline, mild cognitive impairment, and dementia due to various etiologies completed the MMSE and MoCA concurrently. We described both screeners, including at the item level. Then, using linear regressions, we investigated how age, sex, education, and diagnosis affected total scores on both instruments. Next, in linear mixed models, we treated the two screeners as repeated measures and analyzed the influence of these characteristics on the relationship between the instruments' total scores. Finally, we linked total scores using equipercentile equating, accounting for relevant patient characteristics. Results: MMSE scores (mean ± standard deviation: 25.0 ± 4.6) were higher than MoCA scores (21.2 ± 5.4), and MMSE items generally showed less variation than MoCA items. Both instruments' scores were individually influenced by age, sex, education, and diagnosis. The relationship between the screeners was moderated by age (estimate = −0.01, 95% confidence interval = [−0.03, −0.00]), education (0.14 [0.10, 0.18]), and diagnosis. These were accounted for when producing crosswalk tables based on equipercentile equating. Conclusions: Accounting for the influence of patient characteristics, we created crosswalk tables to convert MMSE scores to MoCA scores, and vice versa. These tables may facilitate collaboration between clinicians and researchers and could allow larger, pooled analyses of global cognitive functioning in older adults. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Gene Expression Imputation Across Multiple Tissue Types Provides Insight Into the Genetic Architecture of Frontotemporal Dementia and Its Clinical Subtypes

Author

Ferrari, Raffaele, Hernandez, Dena G., Nalls, Michael A., Rohrer, Jonathan D., Ramasamy, Adaikalavan, Kwok, John B.J., Dobson-Stone, Carol, Brooks, William S., Schofield, Peter R., Halliday, Glenda M., Hodges, John R., Piguet, Olivier, Bartley, Lauren, Thompson, Elizabeth, Hernández, Isabel, Ruiz, Agustín, Boada, Mercè, Borroni, Barbara, Padovani, Alessandro, Cruchaga, Carlos, Cairns, Nigel J., Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Forloni, Gianluigi, Galimberti, Daniela, Fenoglio, Chiara, Serpente, Maria, Scarpini, Elio, Clarimón, Jordi, Lleó, Alberto, Blesa, Rafael, Waldö, Maria Landqvist, Nilsson, Karin, Nilsson, Christer, Mackenzie, Ian R.A., Hsiung, Ging-Yuek R., Mann, David M.A., Grafman, Jordan, Morris, Christopher M., Attems, Johannes, Griffiths, Timothy D., McKeith, Ian G., Thomas, Alan J., Pietrini, Pietro, Huey, Edward D., Wassermann, Eric M., Baborie, Atik, Jaros, Evelyn, Tierney, Michael C., Pastor, Pau, Razquin, Cristina, Ortega-Cubero, Sara, Alonso, Elena, Perneczky, Robert, Diehl-Schmid, Janine, Alexopoulos, Panagiotis, Kurz, Alexander, Rainero, Innocenzo, Rubino, Elisa, Pinessi, Lorenzo, Rogaeva, Ekaterina, St. George-Hyslop, Peter, Rossi, Giacomina, Tagliavini, Fabrizio, Giaccone, Giorgio, Rowe, James B., Schlachetzki, Johannes C.M., Uphill, James, Collinge, John, Mead, Simon, Danek, Adrian, Van Deerlin, Vivianna M., Grossman, Murray, Trojanowski, John Q., van der Zee, Julie, Van Broeckhoven, Christine, Cappa, Stefano F., Le Ber, Isabelle, Hannequin, Didier, Golfier, Véronique, Vercelletto, Martine, Brice, Alexis, Nacmias, Benedetta, Sorbi, Sandro, Bagnoli, Silvia, Piaceri, Irene, Nielsen, Jørgen E., Hjermind, Lena E., Riemenschneider, Matthias, Mayhaus, Manuel, Ibach, Bernd, Gasparoni, Gilles, Pichler, Sabrina, Gu, Wei, Rossor, Martin N., Fox, Nick C., Warren, Jason D., Spillantini, Maria Grazia, Morris, Huw R., Rizzu, Patrizia, Heutink, Peter, Snowden, Julie S., Rollinson, Sara, Richardson, Anna, Gerhard, Alexander, Bruni, Amalia C., Maletta, Raffaele, Frangipane, Francesca, Cupidi, Chiara, Bernardi, Livia, Anfossi, Maria, Gallo, Maura, Conidi, Maria Elena, Smirne, Nicoletta, Rademakers, Rosa, Baker, Matt, Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Knopman, David, Josephs, Keith A., Boeve, Bradley F., Parisi, Joseph E., Seeley, William W., Miller, Bruce L., Karydas, Anna M., Rosen, Howard, van Swieten, John C., Dopper, Elise G.P., Seelaar, Harro, Pijnenburg, Yolande A.L., Scheltens, Philip, Logroscino, Giancarlo, Capozzo, Rosa, Novelli, Valeria, Puca, Annibale A., Franceschi, Massimo, Postiglione, Alfredo, Milan, Graziella, Sorrentino, Paolo, Kristiansen, Mark, Chiang, Huei-Hsin, Graff, Caroline, Pasquier, Florence, Rollin, Adeline, Deramecourt, Vincent, Lebert, Florence, Kapogiannis, Dimitrios, Ferrucci, Luigi, Pickering-Brown, Stuart, Singleton, Andrew B., Hardy, John, Momeni, Parastoo, Reus, Lianne M., Pasaniuc, Bogdan, Posthuma, Danielle, Boltz, Toni, and Ophoff, Roel A.

Published
2021
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14. Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer’s disease subgroups

Author

Groot, Colin, Grothe, Michel J., Mukherjee, Shubhabrata, Jelistratova, Irina, Jansen, Iris, van Loenhoud, Anna Catharina, Risacher, Shannon L., Saykin, Andrew J., Mac Donald, Christine L., Mez, Jesse, Trittschuh, Emily H., Gryglewski, Gregor, Lanzenberger, Rupert, Pijnenburg, Yolande A.L., Barkhof, Frederik, Scheltens, Philip, van der Flier, Wiesje M., Crane, Paul K., and Ossenkoppele, Rik

Published
2021
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16. Distinctive cell-free DNA methylation characterizes presymptomatic genetic frontotemporal dementia

Author

Giannini, Lucia A.A., Boers, Ruben G., van der Ende, Emma L., Poos, Jackie M., Jiskoot, Lize C., Boers, Joachim B., van IJcken, Wilfred F.J., Dopper, Elise G., Pijnenburg, Yolande A.L., Seelaar, Harro, Meeter, Lieke H., van Rooij, Jeroen G.J., Scheper, Wiep, Gribnau, Joost, van Swieten, John C., Giannini, Lucia A.A., Boers, Ruben G., van der Ende, Emma L., Poos, Jackie M., Jiskoot, Lize C., Boers, Joachim B., van IJcken, Wilfred F.J., Dopper, Elise G., Pijnenburg, Yolande A.L., Seelaar, Harro, Meeter, Lieke H., van Rooij, Jeroen G.J., Scheper, Wiep, Gribnau, Joost, and van Swieten, John C.

Abstract

Objective: Methylation of plasma cell-free DNA (cfDNA) has potential as a marker of brain damage in neurodegenerative diseases such as frontotemporal dementia (FTD). Here, we study methylation of cfDNA in presymptomatic and symptomatic carriers of genetic FTD pathogenic variants, next to healthy controls. Methods: cfDNA was isolated from cross-sectional plasma of 10 presymptomatic carriers (4 C9orf72, 4 GRN, and 2 MAPT), 10 symptomatic carriers (4 C9orf72, 4 GRN, and 2 MAPT), and 9 healthy controls. Genome-wide methylation of cfDNA was determined using a high-resolution sequencing technique (MeD-seq). Cumulative scores based on the identified differentially methylated regions (DMRs) were estimated for presymptomatic carriers (vs. controls and symptomatic carriers), and reevaluated in a validation cohort (8 presymptomatic: 3 C9orf72, 3 GRN, and 2 MAPT; 26 symptomatic: 7 C9orf72, 6 GRN, 12 MAPT, and 1 TARDBP; 13 noncarriers from genetic FTD families). Results: Presymptomatic carriers showed a distinctive methylation profile compared to healthy controls and symptomatic carriers. Cumulative DMR scores in presymptomatic carriers enabled to significantly differentiate presymptomatic carriers from healthy controls (p < 0.001) and symptomatic carriers (p < 0.001). In the validation cohort, these scores differentiated presymptomatic carriers from symptomatic carriers (p ≤ 0.007) only. Transcription-start-site methylation in presymptomatic carriers, generally associated with gene downregulation, was enriched for genes involved in ubiquitin-dependent processes, while gene body methylation, generally associated with gene upregulation, was enriched for genes involved in neuronal cell processes. Interpretation: A distinctive methylation profile of cfDNA characterizes the presymptomatic stage of genetic FTD, and could reflect neuronal death in this stage.

Published
2024

17. Visual associative learning to detect early episodic memory deficits and distinguish Alzheimer's disease from other types of dementia.

Author

Dubbelman, Mark A., Tomassen, Jori, van der Landen, Sophie M., Bakker, Els, Kamps, Suzie, van Unnik, Annemartijn A.J.M., van de Glind, Marie-Christine A.B.J., van der Vlies, Annelies E., Koene, Ted, Leeuwis, Anna E., Barkhof, Frederik, van Harten, Argonde C., Teunissen, Charlotte, van de Giessen, Elsmarieke, Lemstra, Afina W., Pijnenburg, Yolande A.L., Ponds, Rudolf W.H., and Sikkes, Sietske A.M.

Subjects
ALZHEIMER'S disease, EPISODIC memory, MAGNETIC resonance imaging, VISUAL learning, ASSOCIATIVE learning
Abstract

Objective: We investigated how well a visual associative learning task discriminates Alzheimer's disease (AD) dementia from other types of dementia and how it relates to AD pathology. Methods: 3,599 patients (63.9 ± 8.9 years old, 41% female) from the Amsterdam Dementia Cohort completed two sets of the Visual Association Test (VAT) in a single test session and underwent magnetic resonance imaging. We performed receiver operating curve analysis to investigate the VAT's discriminatory ability between AD dementia and other diagnoses and compared it to that of other episodic memory tests. We tested associations between VAT performance and medial temporal lobe atrophy (MTA), and amyloid status (n = 2,769, 77%). Results: Patients with AD dementia performed worse on the VAT than all other patients. The VAT discriminated well between AD and other types of dementia (area under the curve range 0.70–0.86), better than other episodic memory tests. Six-hundred forty patients (17.8%) learned all associations on VAT-A, but not on VAT-B, and they were more likely to have higher MTA scores (odds ratios range 1.63 (MTA 0.5) through 5.13 for MTA ≥ 3, all p <.001) and to be amyloid positive (odds ratio = 3.38, 95%CI = [2.71, 4.22], p <.001) than patients who learned all associations on both sets. Conclusions: Performance on the VAT, especially on a second set administered immediately after the first, discriminates AD from other types of dementia and is associated with MTA and amyloid positivity. The VAT might be a useful, simple tool to assess early episodic memory deficits in the presence of AD pathology. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Rationale and Design of the “DIagnostic and Prognostic Precision Algorithm for behavioral variant Frontotemporal Dementia” (DIPPA-FTD) Study: A Study Aiming to Distinguish Early Stage Sporadic FTD from Late-Onset Primary Psychiatric Disorders

Author

de Boer, Sterre C.M., primary, Riedl, Lina, additional, Fenoglio, Chiara, additional, Rue, Ishana, additional, Landin-Romero, Ramon, additional, Matis, Sophie, additional, Chatterton, Zac, additional, Galimberti, Daniela, additional, Halliday, Glenda, additional, Diehl-Schmid, Janine, additional, Piguet, Olivier, additional, Pijnenburg, Yolande A.L., additional, and Ducharme, Simon, additional

Published
2023
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21. Differential Expression of Synaptic Biomarkers in the Cerebrospinal Fluid Differentiates Behavioural Variant of Frontotemporal Dementia from Primary Psychiatric Disorders and Alzheimer’s Disease

Author

Das, Shreyasee, primary, van Engelen, Marie‐Paule E., additional, Goossens, Julie, additional, Jacobs, Dirk, additional, Bongers, Bram, additional, Fieldhouse, Jay L.P., additional, Pijnenburg, Yolande A.L., additional, Teunissen, Charlotte E., additional, Vanmechelen, Eugeen, additional, and Verberk, Inge M.W., additional

Published
2023
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22. Automated FreeSurfer segmentation and visual quality control in 10,000 MRI scans from a large memory clinic cohort

Author

Bocancea, Diana I., primary, den Braber, Anouk, additional, Jiang, Chenyang, additional, Coomans, Emma M., additional, van Unnik, Annemartijn A. J. M., additional, van Veen, Julia M.L., additional, Ribberink, Marieke, additional, Reijner, Niels, additional, Saddal, Shalina, additional, Mastenbroek, Sophie E, additional, van Gils, Aniek M., additional, Kluin, Caro M., additional, de Leeuw, Diederick Martijn, additional, Vromen, Eleonora M., additional, Bekkers, Lotta, additional, Georgallidou, Margarita, additional, van der Landen, Sophie M., additional, Baumann, Jana M., additional, Heuvelink, Joost, additional, Reus, Lianne M., additional, Lorenzini, Luigi, additional, Kamps, Suzie, additional, Bouman, Sophie P.H., additional, Singleton, Ellen Hanna, additional, de Boer, Sterre C.M., additional, Rousset, Rebecca Z., additional, Kuijper, Bart, additional, Verhagen, Eline, additional, Smit, Dimas, additional, Rikken, Roos M., additional, Visser, Pieter Jelle, additional, Bouwman, Femke H., additional, Barkhof, Frederik, additional, Lemstra, Afina W., additional, Pijnenburg, Yolande A.L., additional, van der Flier, Wiesje M., additional, Venkatraghavan, Vikram, additional, and Tijms, Betty M., additional

Published
2023
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24. Individualised prognostic models using plasma biomarkers for clinical progression to Alzheimer’s disease dementia in non‐demented elderly

Author

Honey, Madison I. J., primary, van Maurik, Ingrid S., additional, van Harten, Argonde C., additional, Gouda, Mariam, additional, Kroeze, Lior A., additional, van Leeuwenstijn, Mardou S. S. A., additional, Mank, Arenda, additional, Trieu, Calvin, additional, Pijnenburg, Yolande A.L., additional, van der Flier, Wiesje M., additional, Wilson, David, additional, Teunissen, Charlotte E., additional, and Verberk, Inge M.W., additional

Published
2023
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25. CSF proteomics in autosomal dominant Alzheimer’s disease highlights parallels with sporadic disease

Author

van der Ende, Emma L., primary, in ’t Veld, Sjors G.J.G., additional, Hanskamp, Iris, additional, Van der lee, Sven J, additional, Dijkstra, Janna I.R., additional, van Swieten, John C., additional, Irwin, David J., additional, Chen‐Plotkin, Alice, additional, Hu, William T., additional, Lemstra, Afina W., additional, Pijnenburg, Yolande A.L., additional, van der Flier, Wiesje M., additional, del Campo, Marta, additional, Teunissen, Charlotte E., additional, and Vermunt, Lisa, additional

Published
2023
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28. Tau‐PET signal in Alzheimer’s disease is related to immune activation and synaptic signaling measured with CSF proteomics

Author

Rikken, Roos M., primary, Vromen, Eleonora M., additional, Coomans, Emma M., additional, Visser, Denise, additional, Barkhof, Frederik, additional, Boellaard, Ronald, additional, Golla, Sandeep S.V., additional, van Berckel, Bart N.M., additional, Ossenkoppele, Rik, additional, den Braber, Anouk, additional, Vijverberg, Everard G.B., additional, van der Flier, Wiesje M., additional, Pijnenburg, Yolande A.L., additional, Teunissen, Charlotte E., additional, Visser, Pieter Jelle, additional, van de Giessen, Elsmarieke, additional, and Tijms, Betty M., additional

Published
2023
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29. Visual rating scales of atrophy to differentiate Frontotemporal dementia from Primary psychiatric disorder: results from DIPPA study

Author

Fumagalli, Giorgio G, primary, Sorrentino, Federica, additional, de Boer, Sterre C.M., additional, Riedl, Lina, additional, Landin‐Romero, Ramon, additional, Matis, Sophie, additional, Southwood, Dean, additional, Chatterton, Zac, additional, Diehl‐Schmid, Janine, additional, Halliday, Glenda M, additional, Ducharme, Simon, additional, Piguet, Olivier, additional, Pijnenburg, Yolande A.L., additional, and Galimberti, Daniela, additional

Published
2023
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30. Plasma protein profiling reveals novel specific biomarkers reflecting the multifactorial nature of Alzheimer´s disease continuum

Author

Bellomo, Giovanni, primary, in ’t Veld, Sjors G.J.G., additional, Doecke, James D, additional, Quesada, Carlos, additional, Vermunt, Lisa, additional, Alcolea, Daniel, additional, Halbgebauer, Steffen, additional, Mattsson‐Carlgren, Niklas, additional, Veverova, Katerina, additional, Boonkamp, Lynn, additional, Hok‐A‐Hin, Yanaika S., additional, Fowler, Christopher J, additional, Fortea, Juan, additional, Gaetani, Lorenzo, additional, Toja, Andrea, additional, Pijnenburg, Yolande A.L., additional, Lemstra, Afina W., additional, van der Flier, Wiesje M., additional, Hort, Jakub, additional, Otto, Markus, additional, Hansson, Oskar, additional, Masters, Colin L, additional, Lleó, Alberto, additional, Parnetti, Lucilla, additional, Teunissen, Charlotte E., additional, and del Campo, Marta, additional

Published
2023
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31. Impact of sharing Alzheimer’s disease biomarker results with individuals without dementia: a systematic review and meta‐analysis of empirical data

Author

van der Schaar, Jetske, primary, Visser, Leonie N.C., additional, Ket, Johannes C.F., additional, Groot, Colin, additional, Pijnenburg, Yolande A.L., additional, Scheltens, Philip, additional, Bredenoord, Annelien L., additional, Hoven, Mariette A., additional, and van der Flier, Wiesje M., additional

Published
2023
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32. Computerized decision support is an effective approach to select memory clinic patients for amyloid‐PET

Author

Rhodius‐ Meester, Hanneke F.M., primary, van Maurik, Ingrid S., additional, Collij, Lyduine E., additional, van Gils, Aniek M., additional, Koikkalainen, Juha, additional, Tolonen, Antti, additional, Pijnenburg, Yolande A.L., additional, Barkhof, Frederik, additional, van de Giessen, Elsmarieke, additional, Lötjönen, Jyrki, additional, and van der Flier, Wiesje M., additional

Published
2023
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34. Mastermind of the Alzheimer’s blood‐based biomarkers: development of cutoffs and a visualization tool for use in clinical practice

Author

Verberk, Inge M.W., primary, Kingma, Maurice Y., additional, van Harten, Argonde C., additional, den Braber, Anouk, additional, Vigneswaran, Sinthujah, additional, Gouda, Mariam, additional, van Engelen, Marie‐Paule E., additional, Lemstra, Afina W., additional, Pijnenburg, Yolande A.L., additional, van der Flier, Wiesje M., additional, Schut, Martijn C., additional, Wilson, David, additional, and Teunissen, Charlotte E., additional

Published
2023
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35. Premorbid musical experience influences socio‐emotional functioning in behavioural variant frontotemporal dementia

Author

Hooft, Jochum J., primary, Benhamou, Elia, additional, Herreros, Claudia Albero, additional, Jiang, Jessica, additional, Levett, Benjamin, additional, Core, Lucy, additional, Requena‐Komuro, Mai‐Carmen, additional, Hardy, Chris JD, additional, Tijms, Betty M., additional, Pijnenburg, Yolande A.L., additional, and Warren, Jason D, additional

Published
2023
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36. Data driven criteria for genetic testing result in an efficient selection of patients with genetic dementia in a clinical setting

Author

Lee, Sven J, primary, Hulsman, Marc, additional, van Spaendonk, Rosalina M.L., additional, Schaar, Jetske, additional, Dijkstra, Janna I.R., additional, van der Flier, Wiesje M., additional, Elting, Mariet, additional, Reinders, Marcel JT, additional, Rojas, Itziar, additional, Haelst, Mieke M., additional, Geus, Christa, additional, Pijnenburg, Yolande A.L., additional, and Holstege, Henne, additional

Published
2023
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37. Data‐driven analysis of most common neurodegenerative dementias reveals atrophy patterns associated with overlapping cognitive symptoms

Author

Venkatraghavan, Vikram, primary, Bocancea, Diana I., additional, den Braber, Anouk, additional, Dubbelman, Mark A., additional, Jiang, Chenyang, additional, Coomans, Emma M., additional, van Unnik, Annemartijn A. J. M., additional, van Veen, Julia M.L., additional, Ribberink, Marieke, additional, Reijner, Niels, additional, Saddal, Shalina, additional, Mastenbroek, Sophie E, additional, van Gils, Aniek M., additional, Kluin, Caro M., additional, de Leeuw, Diederick Martijn, additional, Vromen, Eleonora M., additional, Bekkers, Lotta, additional, Georgallidou, Margarita, additional, van der Landen, Sophie M., additional, Baumann, Janna M., additional, Heuvelink, Joost, additional, Reus, Lianne M., additional, Lorenzini, Luigi, additional, Kamps, Suzie, additional, Bouman, Sophie P.H., additional, Singleton, Ellen Hanna, additional, de Boer, Sterre C.M., additional, Rousset, Rebecca Z., additional, Kuijper, Bart, additional, Verhagen, Eline, additional, Smit, Dimas, additional, Rikken, Roos M., additional, Sikkes, Sietske A.M., additional, Visser, Pieter Jelle, additional, Bouwman, Femke H., additional, Barkhof, Frederik, additional, Lemstra, Afina W., additional, Pijnenburg, Yolande A.L., additional, van der Flier, Wiesje M., additional, and Tijms, Betty M., additional

Published
2023
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38. Amygdala volume as neuroimaging marker of limbic‐predominant age‐related TDP‐43 encephalopathy (LATE) in neurodegenerative disease: a post‐mortem MRI and pathology study

Author

Wesseling, Alex, primary, Calandri, Ismael Luis, additional, Ossenkoppele, Rik, additional, van de Berg, Wilma D.J., additional, Rozemuller, Annemieke J.M., additional, Pijnenburg, Yolande A.L., additional, Hoozemans, Jeroen, additional, and Jonkman, Laura E., additional

Published
2023
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40. Factors modifying the association between blood‐based biomarkers for Alzheimer’s disease and amyloid status

Author

Vigneswaran, Sinthujah, primary, Verberk, Inge M.W., additional, Gouda, Mariam, additional, Trieu, Calvin, additional, Claessen, Thomas, additional, van de Giessen, Elsmarieke, additional, Lemstra, Afina W., additional, Wilson, David, additional, Pijnenburg, Yolande A.L., additional, van der Flier, Wiesje M., additional, Teunissen, Charlotte E., additional, and van Harten, Argonde C., additional

Published
2023
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41. Can escapees of familial AD help identify protective factors? A case report of an extremely resilient PSEN1 carrier

Author

Smulders, Michelle N.C.A., primary, Dijkstra, Janna I.R., additional, Visser, Denise, additional, Vermunt, Lisa, additional, Giessen, Elsmarieke, additional, Pijnenburg, Yolande A.L., additional, Holstege, Henne, additional, van der Flier, Wiesje M., additional, Ossenkoppele, Rik, additional, and van der Lee, Sven J, additional

Published
2023
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43. Motor neuron symptoms and pathology burden in de medulla oblongata of FTLD‐TDP brain donors

Author

Scarioni, Marta, primary, de Koning, Florianne, additional, Gami‐Patel, Priya, additional, Fiondella, Luigi, additional, Timar, Yannick, additional, Rozemuller, Annemieke J.M., additional, Hoozemans, Jeroen, additional, Aronica, Eleonora, additional, Raaphorst, Joost, additional, Pijnenburg, Yolande A.L., additional, and Dijkstra, Anke A., additional

Published
2023
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45. ABOARD Cohort; a national initiative to involve citizens in AD research

Author

Rhodius‐Meester, Hanneke F.M., primary, de Boer, Casper, additional, Handgraaf, Dédé, additional, Claassen, Jurgen A.H.R., additional, de Haan, Romy, additional, Hempenius, Liesbeth, additional, van Munster, Barbara C., additional, van Strien, Astrid M, additional, de Vugt, Marjolein, additional, Arts, Derk, additional, Kooistra, Minke, additional, de Rijke, Tanja J., additional, Beusink, Miriam, additional, Pijnenburg, Yolande A.L., additional, and van der Flier, Wiesje M., additional

Published
2023
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46. CSF proteome profiling identifies novel biomarkers for Frontotemporal Dementia and its pathological subtypes

Author

Hok‐A‐Hin, Yanaika S., primary, Vermunt, Lisa, additional, Peeters, Carel F.W., additional, van der Ende, Emma L., additional, de Boer, Sterre C.M., additional, Meeter, Lieke H., additional, van Swieten, John C., additional, Hu, William T., additional, Lleó, Alberto, additional, Alcolea, Daniel, additional, Engelborghs, Sebastiaan, additional, Sieben, Anne, additional, Chen‐Plotkin, Alice, additional, Irwin, David J., additional, van der Flier, Wiesje M., additional, Pijnenburg, Yolande A.L., additional, Teunissen, Charlotte E., additional, and del Campo, Marta, additional

Published
2023
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47. Plasma pTau181 and biomarker combinations to identify Alzheimer´s disease at any stage along the AD continuum compared with both controls and non‐AD dementia

Author

Doecke, James D, primary, Bellomo, Giovanni, additional, Vermunt, Lisa, additional, Alcolea, Daniel, additional, Halbgebauer, Steffen, additional, in ’t Veld, Sjors G.J.G., additional, Mattsson‐Carlgren, Niklas, additional, Veverova, Katerina, additional, Fowler, Christopher J, additional, Boonkamp, Lynn, additional, Koel‐Simmerlink, Marleen, additional, Hussainali, Zulaiga, additional, Ruiters, Daimy N., additional, Gaetani, Lorenzo, additional, Toja, Andrea, additional, Fortea, Juan, additional, Pijnenburg, Yolande A.L., additional, Lemstra, Afina W., additional, van der Flier, Wiesje M., additional, Hort, Jakub, additional, Otto, Markus, additional, Hansson, Oskar, additional, Parnetti, Lucilla, additional, Masters, Colin L, additional, Lleó, Alberto, additional, del Campo, Marta, additional, and Teunissen, Charlotte E., additional

Published
2023
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50. TREM2 AD risk variants impact pTau and microglia and astrocyte related biomarkers in cognitively unimpaired subjects

Author

Hsiao‐Nakamoto, Jennifer, primary, Davis, Sonnet, additional, Suh, Jung, additional, Model, Fabian, additional, Lee, Sven J, additional, van der Flier, Wiesje M., additional, Pijnenburg, Yolande A.L., additional, Van Bokhoven, Pieter, additional, Teunissen, Charlotte E., additional, Scearce‐Levie, Kimberly, additional, and Huang, Fen, additional

Published
2023
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