Search

Your search keyword '"Pignon, Jean-Pierre"' showing total 651 results
Start Over Author "Pignon, Jean-Pierre"
651 results on '"Pignon, Jean-Pierre"'

1. Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis

Author

Le Teuff, Gwénaël, Cozic, Nathalie, Boyer, Jean-Christophe, Boige, Valérie, Diasio, Robert B., Taieb, Julien, Meulendijks, Didier, Palles, Claire, Schwab, Matthias, Deenen, Maarten, Largiadèr, Carlo R., Marinaki, Anthony, Jennings, Barbara A., Wettergren, Yvonne, Di Paolo, Antonello, Gross, Eva, Budai, Barna, Ackland, Stephen P., van Kuilenburg, André B. P., McLeod, Howard L., Milano, Gérard, Thomas, Fabienne, Loriot, Marie-Anne, Kerr, David, Schellens, Jan H. M., Laurent-Puig, Pierre, Shi, Qian, Pignon, Jean-Pierre, and Etienne-Grimaldi, Marie-Christine

Published
2024
Full Text
View/download PDF

2. Standard versus fractionated high-dose cisplatin plus radiation for locally advanced head and neck cancer: Results of the CisFRad (GORTEC 2015-02) randomized phase II trial

Author

Borel, Christian, Sun, Xu-Shan, Coutte, Alexandre, Bera, Guillaume, Sire, Christian, Zanetta, Sylvie, Alfonsi, Marc, Janoray, Guillaume, Chatellier, Thierry, Garcia-Ramirez, Muriel, Gherga, Elisabeta, Hammoud, Yasser, Burgy, Mickaël, Etienne-Selloum, Nelly, Pechery, Adeline, Girard-Calais, Marie-Hélène, Velten, Michel, Pignon, Jean-Pierre, Wanneveich, Mathilde, and Bourhis, Jean

Published
2024
Full Text
View/download PDF

4. Hepatic arterial oxaliplatin plus intravenous 5-fluorouracil and cetuximab for first-line treatment of colorectal liver metastases: A multicenter phase II trial

Author

Malka, David, Verret, Benjamin, Faron, Matthieu, Guimbaud, Rosine, Caramella, Caroline, Edeline, Julien, Galais, Marie-Pierre, Bengrine-Lefevre, Leïla, Smith, Denis, Dupont-Bierre, Eric, De Baere, Thierry, Goéré, Diane, Dartigues, Peggy, Lacroix, Ludovic, Boige, Valérie, Gelli, Maximiliano, Pignon, Jean-Pierre, and Ducreux, Michel

Published
2023
Full Text
View/download PDF

5. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group

Author

Lacas, Benjamin, Carmel, Alexandra, Landais, Cécile, Wong, Stuart J, Licitra, Lisa, Tobias, Jeffrey S, Burtness, Barbara, Ghi, Maria Grazia, Cohen, Ezra EW, Grau, Cai, Wolf, Gregory, Hitt, Ricardo, Corvò, Renzo, Budach, Volker, Kumar, Shaleen, Laskar, Sarbani Ghosh, Mazeron, Jean-Jacques, Zhong, Lai-Ping, Dobrowsky, Werner, Ghadjar, Pirus, Fallai, Carlo, Zakotnik, Branko, Sharma, Atul, Bensadoun, René-Jean, Redda, Maria Grazia Ruo, Racadot, Séverine, Fountzilas, George, Brizel, David, Rovea, Paolo, Argiris, Athanassios, Nagy, Zoltán Takácsi, Lee, Ju-Whei, Fortpied, Catherine, Harris, Jonathan, Bourhis, Jean, Aupérin, Anne, Blanchard, Pierre, Pignon, Jean-Pierre, Group, MACH-NC Collaborative, Adelstein, DJ, Alfonsi, M, Belkacemi, Y, Bar-Ad, V, Bernier, J, Bratland, Å, Calais, G, Campbell, B, Caudell, J, Chabaud, S, Chamorey, E, Chaukar, D, Choi, KN, Choussy, O, Collette, L, Cruz, JJ, Dani, C, Dauzier, E, Forastiere, AA, Garaud, P, Gregoire, V, Hackshaw, A, Haddad, E, Haffty, BG, Hansen, A, Hayoz, S, Horiot, JC, Jeremic, B, Karrison, TG, Langendijk, JA, Lapeyre, M, Lartigau, E, Leong, T, Le, QT, Lee, PPY, Lewin, F, Lin, A, Lopes, A, Mehta, S, Moon, J, Moyal, E, Occéan, BV, Olmi, P, Orecchia, R, O'Sullivan, B, Overgaard, J, Petit, C, Quon, H, Sanguineti, G, Satar, T, Simes, J, Simon, C, Sire, C, Staar, S, Stromberger, C, Strojan, P, Temam, S, Thomson, D, Timochenko, A, Torri, V, and Tseroni, V

Subjects
Cancer, Clinical Trials and Supportive Activities, Rare Diseases, Clinical Research, 6.5 Radiotherapy and other non-invasive therapies, Evaluation of treatments and therapeutic interventions, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Chemotherapy, Adjuvant, Head and Neck Neoplasms, Humans, Induction Chemotherapy, Randomized Controlled Trials as Topic, Meta-analysis, Review, Individual Patient Data, Randomised Clinical Trials, Chemotherapy, Radiotherapy, Head and Neck Cancer, MACH-NC Collaborative Group, Other Physical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Background and purposeThe Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results.Materials and methodsPublished or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible. Individual patient data were collected and combined using a fixed-effect model. OS was the main endpoint.ResultsFor the main question, 101 trials (18951 patients, median follow-up of 6.5 years) were analyzed. For both questions, there were 16 new (2767 patients) and 11 updated trials. Around 90% of the patients had stage III or IV disease. Interaction between treatment effect on OS and the timing of CT was significant (p

Published
2021

6. Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis

Author

Aupérin, Anne, Blanchard, Pierre, Benhamou, Ellen, Bourhis, Jean, Carmel, Alexandra, Chakrabandhu, Somvilai, Chan, Anthony TC, Chen, Lei, Chen, Ming-Yuan, Chen, Qiu-Yan, Chen, Yong, Chappell, Richard J, Choi, Horace, Chua, Daniel TT, Chua, Melvien Lee Kiang, Fountzilas, George, Higgins, Julian, Hong, Ming Huang, Hong, Ruey-Long, Huang, Pei-Yu, Hui, Edwin Pun, Hsiao, Chin-Fu, Kam, Michael, Koliou, Georgia Angeliki, Kwong, Dora L W, Lacas, Benjamin, Lai, Shu-Chuan, Lam, Ka On, LeBlanc, Michael L, Lee, Anne WM, Lee, Ho Fun Victor, Li, Wen Fei, Lim, Yoke, Ma, Brigette, Ma, Jun, Mai, Hai-Qiang, Mo, Frankie, Moon, James, Ng, Wai Tong, Ngan, Roger, Ollivier, Camille, O'Sullivan, Brian, Petit, Claire, Pignon, Jean-Pierre, Poh, Sharon X, Rücker, Gerta, Sham, Jonathan, Soong, Yoke Lim, Sun, Ying, Tan, Terence, Tang, Lin-Quan, Tung, Yuk, Wee, Joseph, Wu, Xuang, Xu, Tingting, Zhang, Li, Zhang, Yuan, Zhu, Guopei, Lee, Anne, Chan, Anthony T C, Li, Wen-Fei, Ngan, Roger K C, Hui, Edwin P, and Auperin, Anne

Published
2023
Full Text
View/download PDF

8. Meta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients

Author

Aupérin, Anne, Blanchard, Pierre, Benhamou, Ellen, Bourhis, Jean, Carmel, Alexandra, Chakrabandhu, Somvilai, TC Chan, Anthony, Chen, Lei, Chen, Ming-Yuan, Chen, Qiu-Yan, Chen, Yong, Chappell, Richard J, Choi, Horace, TT Chua, Daniel, Lee Kiang Chua, Melvin, Fountzilas, George, Higgins, Julian, Hong, Ming-Huang, Hong, Ruey-Long, Huang, Pei-Yu, Pun Hui, Edwin, Hsiao, C.F., Kam, Michael, Angeliki Koliou, Georgia, LW Kwong, Dora, Lacas, Benjamin, Lai, Shu-Chuan, On Lam, Ka, LeBlanc, Michael L, WM Lee, Anne, Fun Victor Lee, Ho, Fei Li, Wen, Ma, Brigette, Ma, Jun, Mai, Hai-Qiang, Mo, Frankie, Moon, James, Tong Ng, Wai, Ngan, Roger, Ollivier, Camille, O'Sullivan, Brian, Petit, Claire, Pierre Pignon, Jean, Poh, Sharon X., Rücker, Gerta, Sham, Jonathan, Lim Soong, Yoke, Sun, Ying, Tan, Terence, Tang, Lin-Quan, Tung, Yuk, Wee, Joseph, Wu, Xuang, Xu, Tingting, Zhang, Li, Zhang, Yuan, Zhu, Guopei, Lee, Anne W.M., Wai Tong, Ng, Chan, Anthony T.C., Hong, Ruey Long, Li, Wen-Fei, Kwong, Dora L.W., Poh, Sharon S.X., and Pignon, Jean-Pierre

Published
2022
Full Text
View/download PDF

9. Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis

Author

Adelstein, D.J., Agarwal, J., Alfonsi, M., Argiris, A., Aupérin, A., Bacigalupo, A., Bar-Ad, V., Bartelink, H., Beadle, B., Belkacemi, Y., Bensadoun, R.J., Bernier, J., Blanchard, P., Bourhis, J., Bratland, Å., Brizel, D., Budach, V., Budach, W., Burtness, B., Calais, G., Campbell, B., Caudell, J., Chabaud, S., Chamorey, E., Chaukar, D., Cheugoua-Zanetsie, M., Cho, K.H., Choussy, O., Cruz Hernandez, J.J., Denham, J.W., Dobrowsky, W., Dominello, M.M, Driessen, C.M.L., Fallai, C., Forastiere, A.A., Fortpied, C., Fountzilas, G., Garaud, P., Garden, A.S., Gery, B., Ghadjar, P., Ghi, M.G., Ghosh Laskar, S., Graff-Cailleaud, P., Grau, C., Gregoire, V., Hackshaw, A., Haddad, E, Haffty, B.G., Hansen, A., Hay, J.H., Hayoz, S., Horiot, J.C., Hitt, R., Jeremic, B., Johansen, J., Jones, C., Julieron, M., Kristensen, C.A., Kumar, S., Lacas, B., Langendijk, J.A., Lapeyre, M., Lartigau, E., Licitra, L., Le, Q.T., Lee, J.W., Lee, P., Lewin, F., Li, Y., Lopes, A., Lotayef, M., Maciejewski, B., Mazeron, J.J., Mehta, S., Michalski, W., Moon, J., Moon, S.H., Moyal, E., Nankivell, M., Nilsson, P., Olmi, P., Orecchia, R., O'Sullivan, B., Overgaard, J., Parmar, M.K.B., Petit, C., Pignon, J.P., Pointreau, Y., Posner, M.R., Poulsen, M.G., Quon, H., Racadot, S., Rosenthal, D.I., Rovea, P., Ruo Redda, M.G., Sanguineti, G., Shenouda, G., Simes, J., Sharma, A., Simon, C., Sire, C., Skladowski, K., Spencer, S., Staar, S., Strojan, P., Stromberger, C., Suwinski, R., Szutkowski, Z., Takácsi-Nagy, Z., Tao, Y.G., Temam, S., Thomson, D., Tobias, J.S., Torres-Saavedra, P., Torri, V., Tripcony, L., Trotti, A., Tseroni, V., van Herpen, C., van Tinteren, H., Vermorken, J., Viegas, C.M.P., Vokes, E.E., Waldron, J., Wernecke, K.D, Widder, J., Wolf, G.T., Wong, S.J., Wu, J.S., Yamazaki, H., Zaktonik, B., Zackrisson, B., Zhong, L.P., Petit, Claire, Lacas, Benjamin, Pignon, Jean-Pierre, Le, Quynh Thu, Grégoire, Vincent, Grau, Cai, Hackshaw, Allan, Zackrisson, Björn, Parmar, Mahesh K B, Lee, Ju-Whei, Ghi, Maria Grazia, Sanguineti, Giuseppe, Temam, Stéphane, Cheugoua-Zanetsie, Maurice, O'Sullivan, Brian, Posner, Marshall R, Vokes, Everett E, Cruz Hernandez, Juan J, Szutkowski, Zbigniew, Lartigau, Eric, Budach, Volker, Suwiński, Rafal, Poulsen, Michael, Kumar, Shaleen, Ghosh Laskar, Sarbani, Mazeron, Jean-Jacques, Jeremic, Branislav, Simes, John, Zhong, Lai-Ping, Overgaard, Jens, Fortpied, Catherine, Torres-Saavedra, Pedro, Bourhis, Jean, Aupérin, Anne, and Blanchard, Pierre

Published
2021
Full Text
View/download PDF

10. Season of radiotherapy and outcomes of head & neck cancer patients in the MACH-NC & MARCH meta-analyses

Author

LIMKIN, Elaine, primary, BLANCHARD, Pierre, additional, LACAS, Benjamin, additional, BOURHIS, Jean, additional, PARMAR, Mahesh, additional, LICITRA, Lisa, additional, LE, Quynh-Thu, additional, YOM, Sue, additional, FORTPIED, Catherine, additional, LANGENDIJK, Johannes, additional, VERMORKEN, Jan B, additional, BERNIER, Jacques, additional, OVERGAARD, Jens, additional, HARRIS, Jonathan, additional, PIGNON, Jean-Pierre, additional, and AUPERIN, Anne, additional

Published
2023
Full Text
View/download PDF

11. Role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery: A subgroup analysis of the meta-analysis of chemotherapy in head and neck cancer

Author

Dauzier, Etienne, Lacas, Benjamin, Blanchard, Pierre, Le, Quynh-Thu, Simon, Christian, Wolf, Gregory, Janot, François, Horiuchi, Masatoshi, Tobias, Jeffrey S., Moon, James, Simes, John, Deshmane, Vinay, Mazeron, Jean-Jacques, Mehta, Samir, Zaktonik, Branko, Tamura, Minoru, Moyal, Elizabeth, Licitra, Lisa, Fortpied, Catherine, Haffty, Bruce G., Ghi, Maria Grazia, Gregoire, Vincent, Harris, Jonathan, Bourhis, Jean, Aupérin, Anne, and Pignon, Jean-Pierre

Published
2019
Full Text
View/download PDF

13. LACE-Bio: Validation of Predictive and/or Prognostic Immunohistochemistry/Histochemistry-based Biomarkers in Resected Non–small-cell Lung Cancer

Author

Seymour, Lesley, Le Teuff, Gwénaël, Brambilla, Elisabeth, Shepherd, Frances A., Soria, Jean-Charles, Kratzke, Robert, Graziano, Stephen, Douillard, Jean-Yves, Rosell, Rafael, Reiman, Anthony, Lacas, Benjamin, Lueza, Beranger, Aviel-Ronen, Sarit, McLeer, Anne, Le Chevalier, Thierry, Pirker, Robert, Filipits, Martin, Dunant, Ariane, Pignon, Jean-Pierre, and Tsao, Ming-Sound

Published
2019
Full Text
View/download PDF

14. The Accuracy of Clinical Staging of Stage I-IIIa Non-Small Cell Lung Cancer: An Analysis Based on Individual Participant Data

Author

Burdett, Sarah, Rydzewska, Larysa H.M., Tierney, Jayne F., Auperin, Anne, Le Chevalier, Thierry, Le Pechoux, Cécile, Pignon, Jean-Pierre, Arriagada, Rodrigo, Johnson, David H., van Meerbeeck, Jan, Parmar, Mahesh K.B., Stephens, Richard J., Stewart, Lesley A., Bunn, Paul A., Dautzenberg, Bertrand, Gilligan, David, Groen, Harry, Knuuttila, Aija, Vallieres, Eric, Rosell, Rafael, Roth, Jack, Scagliotti, Giorgio, Tsuboi, Masahiro, Waller, David, Westeel, Virginie, Wu, Yi-Long, Yang, Xue-Ning, Navani, Neal, and Fisher, David J.

Published
2019
Full Text
View/download PDF

17. Evaluation of heart murmurs in chinchillas (Chinchilla lanigera): 59 cases (1996-2009).

Author

Pignon, Charly, Sanchez-Migallon Guzman, David, Sinclair, Kristen, Baey, Charlotte, Pignon, Jean-Pierre, Mayer, Joerg, Kittleson, Mark D, and Paul-Murphy, Joanne

Subjects
Animals, Chinchilla, Female, Heart Murmurs: diagnosis, veterinary, Male, Odds Ratio, Retrospective Studies
Abstract

To determine the prevalence of heart murmurs in chinchillas (Chinchilla lanigera) and determine whether heart murmurs were associated with cardiac disease.Retrospective multi-institutional case series.260 chinchillas.Medical records of all chinchilla patients evaluated at the Tufts University Foster Hospital for Small Animals between 2001 and 2009, the University of California-Davis William R. Pritchard Veterinary Medical Teaching Hospital between 1996 and 2009, and the University of Wisconsin Veterinary Medical Teaching Hospital between 1998 and 2009 were reviewed.Prevalence of heart murmurs was 23% (59/260). Of 15 chinchillas with heart murmurs that underwent echocardiography, 8 had echocardiographic abnormalities, including dynamic right ventricular outflow tract obstruction, mitral regurgitation, hypertrophy of the left ventricle, tricuspid regurgitation, and hypovolemia. Echocardiographic abnormalities were approximately 29 times as likely (OR, 28.7) to be present in chinchillas with a murmur of grade 3 or higher than in chinchillas without a murmur.Results suggested that heart murmurs are common in chinchillas and that chinchillas with heart murmurs often have echocardiographic abnormalities, with valvular disease being the most common. On the basis of these results, we believe that echocardiography should be recommended for chinchillas with heart murmurs, especially older chinchillas with murmurs of grade 3 or higher. Further prospective studies are needed to accurately evaluate the prevalence of cardiac disease in chinchillas with heart murmurs.

Published
2012

18. Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis

Author

Petit, Claire, primary, Lee, Anne, additional, Ma, Jun, additional, Lacas, Benjamin, additional, Ng, Wai Tong, additional, Chan, Anthony T C, additional, Hong, Ruey-Long, additional, Chen, Ming-Yuan, additional, Chen, Lei, additional, Li, Wen-Fei, additional, Huang, Pei-Yu, additional, Tan, Terence, additional, Ngan, Roger K C, additional, Zhu, Guopei, additional, Mai, Hai-Qiang, additional, Hui, Edwin P, additional, Fountzilas, George, additional, Zhang, Li, additional, Carmel, Alexandra, additional, Kwong, Dora L W, additional, Moon, James, additional, Bourhis, Jean, additional, Auperin, Anne, additional, Pignon, Jean-Pierre, additional, Blanchard, Pierre, additional, Aupérin, Anne, additional, Benhamou, Ellen, additional, Chakrabandhu, Somvilai, additional, Chan, Anthony TC, additional, Chen, Qiu-Yan, additional, Chen, Yong, additional, Chappell, Richard J, additional, Choi, Horace, additional, Chua, Daniel TT, additional, Chua, Melvien Lee Kiang, additional, Higgins, Julian, additional, Hong, Ming Huang, additional, Hui, Edwin Pun, additional, Hsiao, Chin-Fu, additional, Kam, Michael, additional, Koliou, Georgia Angeliki, additional, Lai, Shu-Chuan, additional, Lam, Ka On, additional, LeBlanc, Michael L, additional, Lee, Anne WM, additional, Lee, Ho Fun Victor, additional, Li, Wen Fei, additional, Lim, Yoke, additional, Ma, Brigette, additional, Mo, Frankie, additional, Ngan, Roger, additional, Ollivier, Camille, additional, O'Sullivan, Brian, additional, Petit, Claire, additional, Poh, Sharon X, additional, Rücker, Gerta, additional, Sham, Jonathan, additional, Soong, Yoke Lim, additional, Sun, Ying, additional, Tang, Lin-Quan, additional, Tung, Yuk, additional, Wee, Joseph, additional, Wu, Xuang, additional, Xu, Tingting, additional, and Zhang, Yuan, additional

Published
2023
Full Text
View/download PDF

19. List of Contributors

Author

Au, Kwok Hung, primary, Baloche, Valentin, additional, Beadle, Beth M., additional, Blanchard, Pierre, additional, Busson, Pierre, additional, Chan, Jason W., additional, Chan, Jimmy Y.W., additional, Chan, Yap-Hang, additional, Chang, Amy T.Y., additional, Chen, Honglin, additional, Chen, Zhi-Jian, additional, Chiang, A.K.S., additional, Chiang, Chi Leung, additional, Choi, Horace C.W., additional, Chong, Vincent, additional, Chow, James C.H., additional, Dai, Wei, additional, Deng, W., additional, Futreal, Andy, additional, Han, Fei, additional, Ho, Sai-Yin, additional, Huang, S.C.M., additional, Huang, Shao Hui, additional, Hui, K.F., additional, Jain, Amit, additional, Ji, Mingfang, additional, Kam, Michael K.M., additional, Khong, Pek-Lan, additional, Khor, Damian, additional, Ko, Josephine Mun-Yee, additional, Kwong, Dora L.W., additional, Lai, Jessica W.Y., additional, Lam, Ka On, additional, Lam, Tai Chung, additional, Lam, Tai-Hing, additional, Le, Quynh-Thu, additional, Lee, Anne W.M., additional, Lee, Nancy Y., additional, Lee, Victor H.F., additional, Li, Kenneth W.S., additional, Lin, Jia-Huang, additional, Lin, W.T., additional, Liu, Fei-Fei, additional, Lo, K.W., additional, Lu, Taixiang, additional, Lung, H.L., additional, Li Lung, Maria, additional, Mai, Zhi-Ming, additional, Mak, N.K., additional, Middeldorp, Jaap M., additional, Ming Ip, Dennis Kai, additional, Ng, Alice W.Y., additional, Ng, Wai Tong, additional, Ngan, Roger K.C., additional, Nicholls, John M., additional, O'Sullivan, Brian, additional, Pan, Jian Ji, additional, Pignon, Jean Pierre, additional, Rickinson, A.B., additional, Rischin, Danny, additional, Rozali, Esdy, additional, Stanbridge, Eric, additional, Sze, Henry C.K., additional, Toh, Han Chong, additional, Tsang, C.M., additional, Tsao, S.W., additional, Vardhanabhuti, Vince, additional, Wang, Who-Whong, additional, Wei, William Ignace, additional, Ye, Weimin, additional, Yip, Timothy T.C., additional, Yip, Y.L., additional, Yom, Sue S., additional, Young, Lawrence S., additional, Yu, Yao, additional, Yuan, Hui, additional, Yuen, Kam Tong, additional, and Zong, Jing Feng, additional

Published
2019
Full Text
View/download PDF

21. Data from MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non–Small Cell Lung Carcinoma

Author

Voortman, Johannes, primary, Goto, Akiteru, primary, Mendiboure, Jean, primary, Sohn, Jane J., primary, Schetter, Aaron J., primary, Saito, Motonobu, primary, Dunant, Ariane, primary, Pham, Trung C., primary, Petrini, Iacopo, primary, Lee, Alan, primary, Khan, Mohammed A., primary, Hainaut, Pierre, primary, Pignon, Jean-Pierre, primary, Brambilla, Elisabeth, primary, Popper, Helmut H., primary, Filipits, Martin, primary, Harris, Curtis C., primary, and Giaccone, Giuseppe, primary

Published
2023
Full Text
View/download PDF

22. Supplementary Figure 1 from MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non–Small Cell Lung Carcinoma

Author

Voortman, Johannes, primary, Goto, Akiteru, primary, Mendiboure, Jean, primary, Sohn, Jane J., primary, Schetter, Aaron J., primary, Saito, Motonobu, primary, Dunant, Ariane, primary, Pham, Trung C., primary, Petrini, Iacopo, primary, Lee, Alan, primary, Khan, Mohammed A., primary, Hainaut, Pierre, primary, Pignon, Jean-Pierre, primary, Brambilla, Elisabeth, primary, Popper, Helmut H., primary, Filipits, Martin, primary, Harris, Curtis C., primary, and Giaccone, Giuseppe, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Tables 1-9 from MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non–Small Cell Lung Carcinoma

Author

Voortman, Johannes, primary, Goto, Akiteru, primary, Mendiboure, Jean, primary, Sohn, Jane J., primary, Schetter, Aaron J., primary, Saito, Motonobu, primary, Dunant, Ariane, primary, Pham, Trung C., primary, Petrini, Iacopo, primary, Lee, Alan, primary, Khan, Mohammed A., primary, Hainaut, Pierre, primary, Pignon, Jean-Pierre, primary, Brambilla, Elisabeth, primary, Popper, Helmut H., primary, Filipits, Martin, primary, Harris, Curtis C., primary, and Giaccone, Giuseppe, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Appendix 1 from MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non–Small Cell Lung Carcinoma

Author

Voortman, Johannes, primary, Goto, Akiteru, primary, Mendiboure, Jean, primary, Sohn, Jane J., primary, Schetter, Aaron J., primary, Saito, Motonobu, primary, Dunant, Ariane, primary, Pham, Trung C., primary, Petrini, Iacopo, primary, Lee, Alan, primary, Khan, Mohammed A., primary, Hainaut, Pierre, primary, Pignon, Jean-Pierre, primary, Brambilla, Elisabeth, primary, Popper, Helmut H., primary, Filipits, Martin, primary, Harris, Curtis C., primary, and Giaccone, Giuseppe, primary

Published
2023
Full Text
View/download PDF

25. Individual Participant Data Network Meta-Analysis of Neoadjuvant Chemotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Junction Carcinoma

Author

Faron, Matthieu, Cheugoua-Zanetsie, Maurice, Tierney, Jayne, Thirion, Pierre, Nankivell, Matthew, Winter, Kathryn, Yang, Hong, Shapiro, Joel, Vernerey, Dewi, Smithers, B. Mark, Walsh, Thomas, Piessen, Guillaume, Nilsson, Magnus, Boonstra, Jurjen, Ychou, Marc, Law, Simon, Cunningham, David, de Vathaire, Florent, Stahl, Michael, Urba, Susan, Valmasoni, Michele, Williaume, Danièle, Thomas, Janine, Lordick, Florian, Tepper, Joel, Roth, Jack, Gebski, Val, Burmeister, Bryan, Paoletti, Xavier, van Sandick, Johanna, Fu, Jianhua, Pignon, Jean Pierre, Ducreux, Michel, Michiels, Stefan, Faron, Matthieu, Cheugoua-Zanetsie, Maurice, Tierney, Jayne, Thirion, Pierre, Nankivell, Matthew, Winter, Kathryn, Yang, Hong, Shapiro, Joel, Vernerey, Dewi, Smithers, B. Mark, Walsh, Thomas, Piessen, Guillaume, Nilsson, Magnus, Boonstra, Jurjen, Ychou, Marc, Law, Simon, Cunningham, David, de Vathaire, Florent, Stahl, Michael, Urba, Susan, Valmasoni, Michele, Williaume, Danièle, Thomas, Janine, Lordick, Florian, Tepper, Joel, Roth, Jack, Gebski, Val, Burmeister, Bryan, Paoletti, Xavier, van Sandick, Johanna, Fu, Jianhua, Pignon, Jean Pierre, Ducreux, Michel, and Michiels, Stefan

Abstract

PURPOSE: The optimal neoadjuvant treatment for resectable carcinoma of the thoracic esophagus (TE) or gastroesophageal junction (GEJ) remains a matter of debate. We performed an individual participant data (IPD) network meta-analysis (NMA) of randomized controlled trials (RCTs) to study the effect of chemotherapy or chemoradiotherapy, with a focus on tumor location and histology subgroups. PATIENTS AND METHODS: All, published or unpublished, RCTs closed to accrual before December 31, 2015 and having compared at least two of the following strategies were eligible: upfront surgery (S), chemotherapy followed by surgery (CS), and chemoradiotherapy followed by surgery (CRS). All analyses were conducted on IPD obtained from investigators. The primary end point was overall survival (OS). The IPD-NMA was analyzed by a one-step mixed-effect Cox model adjusted for age, sex, tumor location, and histology. The NMA was registered in PROSPERO (CRD42018107158). RESULTS: IPD were obtained for 26 of 35 RCTs (4,985 of 5,807 patients) corresponding to 12 comparisons for CS-S, 12 for CRS-S, and four for CRS-CS. CS and CRS led to increased OS when compared with S with hazard ratio (HR) = 0.86 (0.75 to 0.99), P = .03 and HR = 0.77 (0.68 to 0.87), P < .001 respectively. The NMA comparison of CRS versus CS for OS gave a HR of 0.90 (0.74 to 1.09), P = .27 (consistency P = .26, heterogeneity P = .0038). For CS versus S, a larger effect on OS was observed for GEJ versus TE tumors (P = .036). For the CRS versus S and CRS versus CS, a larger effect on OS was observed for women (P = .003, .012, respectively). CONCLUSION:Neoadjuvant chemotherapy and chemoradiotherapy were consistently better than S alone across histology, but with some variation in the magnitude of treatment effect by sex for CRS and tumor location for CS. A strong OS difference between CS and CRS was not identified.

Published
2023

26. Impact of thoracic radiotherapy timing in limited-stage small-cell lung cancer: usefulness of the individual patient data meta-analysis

Author

De Ruysscher, D., Le Pechoux, C., Lueza, B., Paris, E., Pignon, J.P., Pijls-Johannesma, M., Veillard, A.S., Arriagada, Rodrigo, Baas, Paul, Blackstock, William, Chevret, Sylvie, Choy, Hak, Crawford, Jeffrey, Dafni, Urania, Dahlberg, Suzanne, De Ruysscher, Dirk, Hackshaw, Allan, Hasan, Baktiar, Johnson, David H., Le Pechoux, Cécile, Lebeau, Bernard, Lovato, James, Lueza, Béranger, Murray, Nevin, O’Brien, Mary, Paris, Emmanuelle, Pignon, Jean-Pierre, Pijls-Johannesma, Madelon, Price, Allan, Spiro, Stephen, Seymour, Lesley, Shibata, Taro, Skarlos, Dimosthenis, Takada, Minoru, Veillard, Anne-Sophie, Wang, Xiaofei, Le Péchoux, C., Johnson, D.H., O'Brien, M., Murray, N., Spiro, S., Wang, X., Takada, M., Lebeau, B., Blackstock, W., Skarlos, D., Baas, P., Choy, H., Price, A., Seymour, L., Arriagada, R., and Pignon, J.-P.

Published
2016
Full Text
View/download PDF

28. How individual participant data meta-analyses have influenced trial design, conduct, and analysis

Author

Alderson, P., Askie, L., Bennett, D., Burdett, S., Clarke, M., Dias, S., Emberson, J., Gueyffier, F., Iorio, A., Macleod, M., Mol, B.W., Moons, C., Parmar, M., Perera, R., Phillips, R., Pignon, J.P., Rees, J., Reitsma, H., Riley, R., Rovers, M., Rydzewska, L., Schmid, C., Shepperd, S., Stenning, S., Stewart, L., Tierney, J., Tudur Smith, C., Vale, C., Welge, J., White, I., Whiteley, W., Tierney, Jayne F., Pignon, Jean-Pierre, Gueffyier, Francois, Clarke, Mike, Askie, Lisa, Vale, Claire L., and Burdett, Sarah

Published
2015
Full Text
View/download PDF

29. Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis

Author

Blanchard, Pierre, Lee, Anne, Marguet, Sophie, Leclercq, Julie, Ng, Wai Tong, Ma, Jun, Chan, Anthony T C, Huang, Pei-Yu, Benhamou, Ellen, Zhu, Guopei, Chua, Daniel T T, Chen, Yong, Mai, Hai-Qiang, Kwong, Dora L W, Cheah, Shie Lee, Moon, James, Tung, Yuk, Chi, Kwan-Hwa, Fountzilas, George, Zhang, Li, Hui, Edwin Pun, Lu, Tai-Xiang, Bourhis, Jean, and Pignon, Jean Pierre

Published
2015
Full Text
View/download PDF

31. Gemcitabine and oxaliplatin with or without cetuximab in advanced biliary-tract cancer (BINGO): a randomised, open-label, non-comparative phase 2 trial

Author

Malka, David, Cervera, Pascale, Foulon, Stéphanie, Trarbach, Tanja, de la Fouchardière, Christelle, Boucher, Eveline, Fartoux, Laetitia, Faivre, Sandrine, Blanc, Jean-Frédéric, Viret, Frédéric, Assenat, Eric, Seufferlein, Thomas, Herrmann, Thomas, Grenier, Julien, Hammel, Pascal, Dollinger, Matthias, André, Thierry, Hahn, Philipp, Heinemann, Volker, Rousseau, Vanessa, Ducreux, Michel, Pignon, Jean-Pierre, Wendum, Dominique, Rosmorduc, Olivier, and Greten, Tim F

Published
2014
Full Text
View/download PDF

33. ANtiangiogenic Second-line Lung cancer Meta-Analysis on individual patient data in non-small cell lung cancer: ANSELMA

Author

Remon, Jordi, primary, Lacas, Benjamin, additional, Herbst, Roy, additional, Reck, Martin, additional, Garon, Edward B., additional, Scagliotti, Giorgio V., additional, Ramlau, Rodryg, additional, Hanna, Nasser, additional, Vansteenkiste, Johan, additional, Yoh, Kiyotaka, additional, Groen, Harry J.M., additional, Heymach, John V., additional, Mandrekar, Sumithra J., additional, Okamoto, Isamu, additional, Neal, Joel W., additional, Heist, Rebecca S., additional, Planchard, David, additional, Pignon, Jean-Pierre, additional, Besse, Benjamin, additional, Besse, B., additional, Lacas, B., additional, Pignon, J.P., additional, Remon, J., additional, Berghmans, T., additional, Dahlberg, S., additional, Felip, E., additional, Berghmans, Thierry, additional, Dahlberg, Suzanne, additional, Felip, Enriqueta, additional, Garon, Edward, additional, Adjei, Alex A., additional, Heist, Rebecca, additional, and Remon, Jordi, additional

Published
2022
Full Text
View/download PDF

34. Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients' data

Author

Mauguen, Audrey, Pignon, Jean-Pierre, Burdett, Sarah, Domerg, Caroline, Fisher, David, Paulus, Rebecca, Mandrekar, Samithra J, Belani, Chandra P, Shepherd, Frances A, Eisen, Tim, Pang, Herbert, Collette, Laurence, Sause, William T, Dahlberg, Suzanne E, Crawford, Jeffrey, O'Brien, Mary, Schild, Steven E, Parmar, Mahesh, Tierney, Jayne F, Pechoux, Cécile Le, and Michiels, Stefan

Published
2013
Full Text
View/download PDF

36. Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000–05): an open-label, randomised, phase 3 trial

Author

Ducreux, Michel, Malka, David, Mendiboure, Jean, Etienne, Pierre-Luc, Texereau, Patrick, Auby, Dominique, Rougier, Philippe, Gasmi, Mohamed, Castaing, Marine, Abbas, Moncef, Michel, Pierre, Gargot, Dany, Azzedine, Ahmed, Lombard-Bohas, Catherine, Geoffroy, Patrick, Denis, Bernard, Pignon, Jean-Pierre, Bedenne, Laurent, and Bouché, Olivier

Published
2011
Full Text
View/download PDF

40. Meta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients

Author

Blanchard, Pierre, primary, Lee, Anne W.M., additional, Carmel, Alexandra, additional, Wai Tong, Ng, additional, Ma, Jun, additional, Chan, Anthony T.C., additional, Hong, Ruey Long, additional, Chen, Ming-Yuan, additional, Chen, Lei, additional, Li, Wen-Fei, additional, Huang, Pei-Yu, additional, Kwong, Dora L.W., additional, Poh, Sharon S.X., additional, Ngan, Roger, additional, Mai, Hai-Qiang, additional, Ollivier, Camille, additional, Fountzilas, George, additional, Zhang, Li, additional, Bourhis, Jean, additional, Aupérin, Anne, additional, Lacas, Benjamin, additional, Pignon, Jean-Pierre, additional, Blanchard, Pierre, additional, Benhamou, Ellen, additional, Chakrabandhu, Somvilai, additional, TC Chan, Anthony, additional, Chen, Qiu-Yan, additional, Chen, Yong, additional, Chappell, Richard J, additional, Choi, Horace, additional, TT Chua, Daniel, additional, Lee Kiang Chua, Melvin, additional, Higgins, Julian, additional, Hong, Ming-Huang, additional, Hong, Ruey-Long, additional, Pun Hui, Edwin, additional, Hsiao, C.F., additional, Kam, Michael, additional, Angeliki Koliou, Georgia, additional, LW Kwong, Dora, additional, Lai, Shu-Chuan, additional, On Lam, Ka, additional, LeBlanc, Michael L, additional, WM Lee, Anne, additional, Fun Victor Lee, Ho, additional, Fei Li, Wen, additional, Ma, Brigette, additional, Mo, Frankie, additional, Moon, James, additional, Tong Ng, Wai, additional, O'Sullivan, Brian, additional, Petit, Claire, additional, Pierre Pignon, Jean, additional, Poh, Sharon X., additional, Rücker, Gerta, additional, Sham, Jonathan, additional, Lim Soong, Yoke, additional, Sun, Ying, additional, Tan, Terence, additional, Tang, Lin-Quan, additional, Tung, Yuk, additional, Wee, Joseph, additional, Wu, Xuang, additional, Xu, Tingting, additional, Zhang, Yuan, additional, and Zhu, Guopei, additional

Published
2022
Full Text
View/download PDF

42. Individual patient data meta-analysis of neoadjuvant chemotherapy followed by surgery versus upfront surgery for carcinoma of the oesophagus or the gastro-oesophageal junction

Author

Faron, Matthieu, primary, Cheugoua-Zanetsie, Armel Maurice, additional, Thirion, Pierre, additional, Nankivell, Matthew, additional, Winter, Kathryn, additional, Cunningham, David, additional, Van der Gaast, Ate, additional, Law, Simon, additional, Langley, Ruth, additional, de Vathaire, Florent, additional, Valmasoni, Michele, additional, Mauer, Muriel, additional, Roth, Jack, additional, Gebski, Val, additional, Burmeister, Bryan H., additional, Paoletti, Xavier, additional, van Sandick, Johanna, additional, Fu, Jianhua, additional, Ducreux, Michel, additional, Blanchard, Pierre, additional, Tierney, Jayne, additional, Pignon, Jean-Pierre, additional, and Michiels, Stefan, additional

Published
2021
Full Text
View/download PDF

43. Prognostic and Predictive Effect of TP53 Mutations in Patients with Non–Small Cell Lung Cancer from Adjuvant Cisplatin–Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis

Author

Ma, Xiaoli, Le Teuff, Gwénaël, Lacas, Benjamin, Tsao, Ming Sound, Graziano, Stephen, Pignon, Jean-Pierre, Douillard, Jean-Yves, Le Chevalier, Thierry, Seymour, Lesley, Filipits, Martin, Pirker, Robert, Jänne, Pasi A., Shepherd, Frances A., Brambilla, Elisabeth, Soria, Jean-Charles, and Hainaut, Pierre

Published
2016
Full Text
View/download PDF

48. Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis

Author

Petit, Claire, primary, Lacas, Benjamin, additional, Pignon, Jean-Pierre, additional, Le, Quynh Thu, additional, Grégoire, Vincent, additional, Grau, Cai, additional, Hackshaw, Allan, additional, Zackrisson, Björn, additional, Parmar, Mahesh K B, additional, Lee, Ju-Whei, additional, Ghi, Maria Grazia, additional, Sanguineti, Giuseppe, additional, Temam, Stéphane, additional, Cheugoua-Zanetsie, Maurice, additional, O'Sullivan, Brian, additional, Posner, Marshall R, additional, Vokes, Everett E, additional, Cruz Hernandez, Juan J, additional, Szutkowski, Zbigniew, additional, Lartigau, Eric, additional, Budach, Volker, additional, Suwiński, Rafal, additional, Poulsen, Michael, additional, Kumar, Shaleen, additional, Ghosh Laskar, Sarbani, additional, Mazeron, Jean-Jacques, additional, Jeremic, Branislav, additional, Simes, John, additional, Zhong, Lai-Ping, additional, Overgaard, Jens, additional, Fortpied, Catherine, additional, Torres-Saavedra, Pedro, additional, Bourhis, Jean, additional, Aupérin, Anne, additional, Blanchard, Pierre, additional, Adelstein, D.J., additional, Agarwal, J., additional, Alfonsi, M., additional, Argiris, A., additional, Aupérin, A., additional, Bacigalupo, A., additional, Bar-Ad, V., additional, Bartelink, H., additional, Beadle, B., additional, Belkacemi, Y., additional, Bensadoun, R.J., additional, Bernier, J., additional, Blanchard, P., additional, Bourhis, J., additional, Bratland, Å., additional, Brizel, D., additional, Budach, V., additional, Budach, W., additional, Burtness, B., additional, Calais, G., additional, Campbell, B., additional, Caudell, J., additional, Chabaud, S., additional, Chamorey, E., additional, Chaukar, D., additional, Cheugoua-Zanetsie, M., additional, Cho, K.H., additional, Choussy, O., additional, Cruz Hernandez, J.J., additional, Denham, J.W., additional, Dobrowsky, W., additional, Dominello, M.M, additional, Driessen, C.M.L., additional, Fallai, C., additional, Forastiere, A.A., additional, Fortpied, C., additional, Fountzilas, G., additional, Garaud, P., additional, Garden, A.S., additional, Gery, B., additional, Ghadjar, P., additional, Ghi, M.G., additional, Ghosh Laskar, S., additional, Graff-Cailleaud, P., additional, Grau, C., additional, Gregoire, V., additional, Hackshaw, A., additional, Haddad, E, additional, Haffty, B.G., additional, Hansen, A., additional, Hay, J.H., additional, Hayoz, S., additional, Horiot, J.C., additional, Hitt, R., additional, Jeremic, B., additional, Johansen, J., additional, Jones, C., additional, Julieron, M., additional, Kristensen, C.A., additional, Kumar, S., additional, Lacas, B., additional, Langendijk, J.A., additional, Lapeyre, M., additional, Lartigau, E., additional, Licitra, L., additional, Le, Q.T., additional, Lee, J.W., additional, Lee, P., additional, Lewin, F., additional, Li, Y., additional, Lopes, A., additional, Lotayef, M., additional, Maciejewski, B., additional, Mazeron, J.J., additional, Mehta, S., additional, Michalski, W., additional, Moon, J., additional, Moon, S.H., additional, Moyal, E., additional, Nankivell, M., additional, Nilsson, P., additional, Olmi, P., additional, Orecchia, R., additional, O'Sullivan, B., additional, Overgaard, J., additional, Parmar, M.K.B., additional, Petit, C., additional, Pignon, J.P., additional, Pointreau, Y., additional, Posner, M.R., additional, Poulsen, M.G., additional, Quon, H., additional, Racadot, S., additional, Rosenthal, D.I., additional, Rovea, P., additional, Ruo Redda, M.G., additional, Sanguineti, G., additional, Shenouda, G., additional, Simes, J., additional, Sharma, A., additional, Simon, C., additional, Sire, C., additional, Skladowski, K., additional, Spencer, S., additional, Staar, S., additional, Strojan, P., additional, Stromberger, C., additional, Suwinski, R., additional, Szutkowski, Z., additional, Takácsi-Nagy, Z., additional, Tao, Y.G., additional, Temam, S., additional, Thomson, D., additional, Tobias, J.S., additional, Torres-Saavedra, P., additional, Torri, V., additional, Tripcony, L., additional, Trotti, A., additional, Tseroni, V., additional, van Herpen, C., additional, van Tinteren, H., additional, Vermorken, J., additional, Viegas, C.M.P., additional, Vokes, E.E., additional, Waldron, J., additional, Wernecke, K.D, additional, Widder, J., additional, Wolf, G.T., additional, Wong, S.J., additional, Wu, J.S., additional, Yamazaki, H., additional, Zaktonik, B., additional, Zackrisson, B., additional, and Zhong, L.P., additional

Published
2021
Full Text
View/download PDF

49. Individual patient data meta-analysis of prophylactic cranial irradiation in locally advanced non-small cell lung cancer

Author

Witlox, Willem J.A., primary, Ramaekers, Bram L.T., additional, Lacas, Benjamin, additional, Le Pechoux, Cecile, additional, Pignon, Jean-Pierre, additional, Sun, Alexander, additional, Wang, Si-Yu, additional, Hu, Chen, additional, Redman, Mary, additional, van der Noort, Vincent, additional, Li, Ning, additional, Guckenberger, Matthias, additional, van Tinteren, Harm, additional, Groen, Harry J.M., additional, Joore, Manuela A., additional, and De Ruysscher, Dirk K.M., additional

Published
2021
Full Text
View/download PDF

50. Tumour-infiltrating lymphocyte density is associated with favourable outcome in patients with advanced non-small cell lung cancer treated with immunotherapy.

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Gataa, Ithar, Mezquita, Laura, Rossoni, Caroline, Auclin, Edouard, Kossai, Myriam, Aboubakar Nana, Frank, Le Moulec, Sylvestre, Massé, Julie, Masson, Morgane, Radosevic-Robin, Nina, Alemany, Pierre, Rouanne, Mathieu, Bluthgen, Virginia, Hendriks, Lizza, Caramella, Caroline, Gazzah, Anas, Planchard, David, Pignon, Jean-Pierre, Besse, Benjamin, Adam, Julien, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Gataa, Ithar, Mezquita, Laura, Rossoni, Caroline, Auclin, Edouard, Kossai, Myriam, Aboubakar Nana, Frank, Le Moulec, Sylvestre, Massé, Julie, Masson, Morgane, Radosevic-Robin, Nina, Alemany, Pierre, Rouanne, Mathieu, Bluthgen, Virginia, Hendriks, Lizza, Caramella, Caroline, Gazzah, Anas, Planchard, David, Pignon, Jean-Pierre, Besse, Benjamin, and Adam, Julien

Abstract

BACKGROUND: The established role of morphological evaluation of tumour-infiltrating lymphocytes (TILs) with immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC) is unknown. We aimed to determine TIL association with the outcome for ICIs and for chemotherapy in advanced NSCLC. METHODS: This is a multicenter retrospective study of a nivolumab cohort of 221 patients treated between November 2012 and February 2017 and a chemotherapy cohort of 189 patients treated between June 2009 and October 2016. Patients with available tissue for stromal TIL evaluation were analysed. The presence of a high TIL count (high-TIL) was defined as ≥10% density. The primary end-point was overall survival (OS). RESULTS: Among the nivolumab cohort, 64% were male, with median age of 63 years, 82.3% were smokers, 77% had performance status ≤1 and 63% had adenocarcinoma histology. High-TIL was observed in 22% patients and associated with OS (hazard ratio [HR] 0.48; 95% confidence interval [95% CI]: 0.28-0.81) and progression-free survival [PFS] (HR = 0.40; 95% CI: 0.25-0.64). Median PFS was 13.0 months (95% CI: 5.0-not reached) with high-TIL versus 2.2 months (95% CI: 1.7-3.0) with the presence of a low TIL count (low-TIL). Median OS for high-TIL was not reached (95% CI: 12.2-not reached) versus 8.4 months (95% CI: 5.0-11.6) in the low-TIL group. High-TIL was associated with the overall response rate (ORR) and disease control rate (DCR) (both, P < .0001). Among the chemotherapy cohort, 69% were male, 89% were smokers, 86% had performance status ≤1 and 90% had adenocarcinoma histology. High-TIL was seen in 37%. Median PFS and OS were 5.7 months (95% CI: 4.9-6.7) and 11.7 months (95% CI: 9.3-13.0), respectively, with no association with TILs. CONCLUSIONS: High-TIL was associated with favourable outcomes in a real-world immunotherapy cohort of patients with NSCLC, but not with chemotherapy, suggesting that TILs may be useful in selecting patients for immunotherapy.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results