152 results on '"Pignatelli, D"'
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2. Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries
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Donmez, A, Goswami, A, Raheja, A, Bhadani, A, El Kady, A, Alniemi, A, Awad, A, Aladl, A, Younis, A, Alwali, A, Khalil, A, Mansour, A, Elkhouly, A, Rashad Temerik, A, Hasan, A, Chied, A, Abdraba, A, Hrora, A, Abdelshafi, A, Maraqa, A, Ghaffar, A, Chekfa, A, Al Balushi, A, Quddus, A, Hammadieh, A, Muntaka, A, Asekun, A, Alshahrani, A, Jowharji, A, Alshukre, A, Khair Etareig, A, Abubakar Abdulkarim, A, Ashiru, A, Alailesh, A, Al-Mallah, A, Baydoun, A, Chaudhry, A, Askin, A, Almutairi, A, Belkhair, A, Abdllah, A, Alhammali, A, Basalim, A, Abouelnagah, A, Ghazal, A, Mohammed, A, Qasem, A, Anadani, A, Jimoh, A, Lawal, A, Khaity, A, Elzoubi, A, Sheshe, A, Cetisli, A, Oyedele, A, Aljahdali, A, Aboelnasr, A, Demessie, A, Bhargava, A, Sonkar, A, Bavaharan, A, Khan, A, Campbell, A, Oyelekan, A, Okunlola, A, Ojewuyi, A, Ekerin, A, Saleh, A, Khairy, A, Muthunayagam, A, Botha, A, Teshome Sahilemariam, A, Nawawi, A, Muhammad, A, Dahiru, A, Yahaya, A, Abdelmalik, A, Anuar, A, Ousseini, A, Leon -Del- Angel, A, Frankel, A, Gyedu, A, Lim, A, Lukac, A, Peckham-Cooper, A, Sabbah, A, Varga, A, Sanou, A, Issaka, A, Ningi, A, Yeshitila, A, Yingess, A, Olugbami, A, Damola-Okesiji, A, Ojo, A, Hashmi, A, Fakoya, A, Ishola, A, Abiodun, A, Ajayi, A, Mouffokes, A, Bonelli, A, Adekoya, A, Akeem Aderogba, A, Ozcan, A, Ayoade, A, Adeyeye, A, Agbaje, A, Talabi, A, Ademuyiwa, A, Adewumiya, A, Aderounmu, A, Adisa, A, Oke, A, Ragab, A, Alzadjali, A, Baksi, A, Jayapalan, A, Md Yunos, A, Pisanu, A, Salazar, A, Salinas Barragan, A, Fox, A, Stollberg, A, Franco, A, Neves, A, Vricheva, A, Hodonou, A, Aghayeva, A, Liaquat, A, Alsultan, A, Morad, A, Kalidis, A, Gkouniaroudi, A, Karakosta, A, Lovi, A, Yevide, A, Duro, A, Rodriguez Gonzalez, A, Tariq, A, Abaidalla, A, Abuhammad, A, Abuhantash, A, Ahmad Zaidi, A, Alahmad Alismael, A, Alayed, A, Alfarwan, A, Alhaj, A, Ali, A, Alroobi, A, Alsheikh, A, Alusef, A, Alzu'Bi, A, Kayali, A, Bouhuwaish, A, Doghaim, A, El-Sherbiney, A, Ramly, A, Raza, A, Qureshi, A, Arnaout, A, Abdelhamid, A, Abuthaher, A, Adel, A, Ahmayda, A, Al-Mouahhed, A, Alagha, A, Albalawi, A, Albhaisi, A, Alrifaee, A, Azam, A, Barakat, A, Al-Hajjaj, A, Dawoud, A, El Shamarka, A, El-Bastwesy, A, Elghrieb, A, Elkhalifa, A, Elmosalamy, A, Elshazli Mahmoud, A, Montaser, A, Gbeadese, A, Haty, A, K. 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Enti, D, Venskutonis, D, Rukavina, D, Caruso, D, Herappe, D, Lee, D, Ofosuhene, D, Hajela, A, Badwan, B, Kulkarni, D, Dhawan, D, Dhillon, J, Mehmood, M, Mahmood, N, Nikam, N, Ramchandani, R, Thind, R, Riazhussain, D, Maqsood, S, Alalawi, Y, Tyagi, H, Kshirsagar, S, Ahmed, H, Juan Carlos, L, Kone, D, Omar, D, Alves, D, Subasinghe, D, Ommi, D, Joshiba, D, Chakarov, D, Arkoh, E, Frimpong-Manso, E, Ada, E, Lincango, E, Lozada Hernandez, E, Hodzic, E, Di Marco, E, Baccalini, E, Baldini, E, Gonzalez Marin, E, Gutierrez, E, Sepulveda, E, Dainius, E, Zhang, E, Yenli, E, Antoniou, E, Kapasakis, E, Baili, E, Poulios, E, Kubiliute, E, Osaze, E, Afeikhena, E, Elshennawy, E, Athanasopoulou, E, Synekidou, E, Ekaladze, E, Tampaki, E, Adam, E, Adel Hamdoun Aziz, E, Yousuf, E, Gialamas, E, Spartalis, E, Bedzhanyan, E, Toma, E, Dauksaite, E, Desiato, E, Dvivedi, E, Hadzhieva, E, Marti Cunat, E, Montalban Martinez, E, Montanari, E, Signaroli, E, Efremidou, E, Gavriil, E, Karakeke, E, Mavrodimitraki, E, Papamattheou, E, Jose, E, Cianci, E, Ciccioli, E, Daleva, E, Locci, E, Lori, E, Silanos, E, Ayala, E, Bankart, E, Brolese, E, Efstathiou, E, Salloum, E, Colak, E, Terzi, E, Ametefe, E, Cagigal Ortega, E, Donnarumma, E, Mina, E, Reitano, E, Wallner, E, Moggia, E, Betz, E, Kontis, E, Anestiadou, E, Gimson, E, Lun, E, Fraser, E, Li, E, Torres De Anda, E, Murphy, E, O'Connell, E, Redondo, E, Francis, E, Haiden, E, Hamed, E, Alkhalifa, E, Dexter, E, Daketsey, E, Setsoafia, E, Mohamed, E, Mohammed, E, Hegab, E, Ay, E, Adinolfi, E, Mbanzabugabo, E, Chin, E, Ahmed, E, Younes, E, Basile, E, Gessa, E, Pontecorvi, E, Romairone, E, Hatangimana, E, Ndizeye, E, Ciofic, E, Dijan, E, Lopez-Negrete Cueto, E, Baker, E, Reid, E, Schmidt, E, Alic, E, Bicakcic, E, Agbowada, E, Colton, E, Downing, E, Haege, E, O'Neill, E, Roussos, E, Nachelleh, E, Adebunmi, E, Obiesie, E, Akakpo, E, Konlan, E, Nwangwu, E, Kafui Ayodeji, E, Ofori, E, Spanoudakis, E, Abate, E, Balik, E, Bozdag, E, Bozkurt, E, Karabulut, E, 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Skiljo, H, Miyasika, H, Altabbaa, H, Haj Freej, H, Abdelazim, H, Habiba, H, Kamal, H, Sabir, H, Zaigham, H, Pehlivan, H, Telci, H, Abuobaida, H, Tetley, H, Taher, H, Aguado Lopez, H, Askarpour, H, Sherif Farouk Ahmed Hassan, H, Devesa, H, Arbogast, H, Nunez Del Barrio, H, Abiyere, H, Delacave, H, Rice, H, Pleass, H, Bradly, H, Islam, H, Lule, H, Abozied, H, Le Roux, H, Hamdar, H, Yaghmour, H, Bileid Bakeer, H, Al Miskry, H, Ulman, H, Abdoun, H, Essalim, H, Yonekura, H, Kato, H, Amin-Tai, H, Kynaston, H, Perez Baca, H, Irfan Khan, H, Amir, H, Elghadban, H, Elfeki, H, Wain, H, Adjei, H, Dabrowski, H, Novak, H, Alzuhd, H, Capote, H, Gomez-Fernandez, H, Stark, H, Willy-Chidire, H, Aouagbe Behanzin, H, Oneizah, H, Dalati, H, Ebied, H, Mahajna, H, Ahmad, H, Altawati, H, Adi, H, Albalawi, H, Alfakeer, H, Embarek, H, Ibrahim, H, Malkawi, H, Ekwuazi, H, Psilopatis, I, Wasiu, I, Kereet, I, Suleiman, I, Fortune, I, Aburumman, I, Adel, I, Adham, I, Ali, I, Arnaout, I, Cakir, I, Fagiri, I, Hajmohammed, I, Ozata, I, Kandil, I, Ahmed, I, Tagreda, I, Garzali, I, Nadi, I, Ogundele, I, Pius Ogolekwu, I, Shariff, I, Jakaityte, I, Abdullah, I, Babajimi-Joseph, I, Guirguis, I, Orji, I, Okoro, I, Obianyo, I, Njere, I, Ugwueke, I, Nzenwa, I, Zerrouq, I, Clementi, I, Neri, I, Yavuz, I, Hoxhaj, I, Fakhradiyev, I, R Fakhradiyev, I, Gomatos, I, Fidoshev, I, Gouazar, I, Alnimer, I, Boudis, I, Boumakhlouf, I, Abdalla, I, Herrero, I, Osman, I, Nasser, I, Singh, I, P S, I, Borges Da Costa, I, Colaco, I, Lourenco, I, Mogarrio, I, Konigsrainer, I, Hamdun, I, Tanase, I, Bokos, I, Contis, I, Demiris, I, Gerogiannis, I, Gogoulis, I, Karatsolis, I, Katsaros, I, Kozadinos, I, Margaris, I, Maroulis, I, Papaconstantinou, I, Siannis, I, Sougkas, I, Spyridakis, I, Tierris, I, Tsakiridis, I, Imihteev, I, Negoi, I, Chatzis, I, Shahbaz, I, Didier, I, Pipia, I, Parwaiz, I, Duran Sanchez, I, Norman, I, Bakaweri, I, Santos, I, Mylona, I, De Haro Jorge, I, Cervera, I, Dajti, I, Datji, I, Matache, I, Russo, I, Aremu, I, Amankwaa, I, Caitens, I, Esparza Estrada, I, Mubezi, I, Gascon Ferrer, I, Serrano, I, Dong, I, Mondi, I, Serfontein, I, Rakshit, I, Kyei, I, Murshed, I, Cabrera, I, Abo Elhagag, I, Alsoubie, I, Lawani, I, Bilgin, I, Cholah, I, Hamzaoglu, I, Maharem, I, Shehadeh, I, Hagbevor, I, Bahikoro, I, Laopeamthong, I, Mikulic, I, Bacic, I, Rakvin, I, Separovic, I, Vidic, I, Conversano, I, Mrazkova, I, Yotsov, I, Ilieva, I, Coza, I, Aljada, I, Hussein, I, Tesfahun, I, Sadiq, I, Martinez Martin Del Campo, J, Mackenzie, J, Maida, J, Kaippally, J, Montero Garcia, J, Andreuccetti, J, Martellucci, J, Secchi, J, Van Niekerk, J, Saunders, J, Duffield, J, Tavares-Ortega, J, Orozco-Perez, J, Mihanovic, J, Wolesky, J, Bryan, J, Bundred, J, Cui, J, Glasbey, J, Casella Mariolo, J, Suliman, J, Mohammad Mohammad, J, Bolanowski, J, Goedeke, J, Grosek, J, Moravik, J, Ringers, J, Roman, J, Chew, J, Maritz, J, Martin, J, Velkoski, J, Wong, J, Garcia-Quijada, J, Tk, J, Siby, J, Mcnab-Hand, J, Gusa, J, 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S., Aljamoudi A., Cheung A. C. K., Gkoutoula A., Kalogeropoulou A., Sarafi A., Abo Al Shamat A., Sanon A. S. T., Sanon A. F., Hiller A., Costas-Chavarri A., Lombardero A., Fraile A., Bojazyah A., Kamal A., Gill A., Hada A., Gulla A., Maciulaityte A., Sukumar A., Landaluce-Olavarria A., Sainz Lete A., Pal A. K., Malik A. A., Horiguchi A., Kocaay A. F., Akinkuolie A., Olabode A., Fadipe A., Akinmade A., Darkwa Boateng A., Appiah-Kubi A. Y., Alkaseek A., Kadamani Abiyomaa A., Anand A., Oppong A., Opoku-Agyapong A., Asharaf A. A., Ahmed A. S., Andani A. -H. D., Alkharusi A. -S., Abd Elsattar A., Alragheai A., Alsalahat A. A., Hawarah A., Aldirani A. N., Shabkah A., Nixon Fulli A. F., Nguyen A., Mustafa A., Joseph A., Huws A., Aregawi A. B., Sanchez Gallego A., Torroella A., Vazquez Melero A., Dauksa A., Abreu Da Silva A., Brun-Peressut A., Barranquero A. G., Gegundez Simon A., Gerundo A., Navarrete-Peon A., Viacava A., Vilar A., Adam A. A., Jarimba A., Johnson A., Nunez Venzor A., Gonzalez Ojeda A., Romero De Diego A., Karamarkovic A., Butyrskii A., Edmundson A., Sidorova A., Thomas A., Tomazic A., Giuliani A., Iodice A., Marano A., Marello A., Ongaro A., Saba A., Anastasi A., Borello A., Broglia A., Carta A., Finocchio A., Francia A., Iacomino A., Izzo A., Ottaiano A., Spaziani A., Strumia A., Biancafarina A., D'Ignazio A., Davolio A., Morello A., Licciardello A., Mazzoni A., Wilkins A., Arekhandia A., Barlas A., Chamzin A., Demetriou A., Giakoustidis A., Kozadinos A., Kyriakidis A., Sarakatsanos A., Rojas A., Saridaki A., Litchinko A., Arnaud A. P., Binder A. -D., Yakubu A., Kavalakat A., Shamsutdinova A., Alberico A., Amendola A., Sanchez-Teran A. I., Lapergola A., Baiden Amissah A., Konigsrainer A., Twumasi A., Alhebshi A., Abbas A., Abdul Rahman A., Abidali A., Abu Tair A., Ahmad A., Al Mukhtar A., Sharq A. A., Alloush A., Amaigl A., Kheirkhah Vakilabad A. A., Bassma A., Hacioglu A. 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F., Ferreras Garcia C., Figueiredo C., Garcia-Salas C., Gonzalez C., Gonzalez Baez C., Gracia-Roche C., Guijarro Moreno C., Hernandez Diaz C., Ferrero C. I., Perez Rivera C. J., Jezieniecki C., Perez - Padron C. J., Leon-Espinoza C., Nuno-Guzman C. M., Macedo Cardoso De Oliveira C., Shiraishi Zapata C., Yanowsky-Gonzalez C., Sorrentino C., Tung C., Cardoso C., Chavarria Noya C., Coutinho C., Korzin C., Maya C., Moreno-Licea C., Panis C., Righetti C., Silva C., Soares-Aquino C., Golliez C., Chiam C., Kamphues C., Rahantasoa Finaritra C. F., Assis C., Henriques C., Quintela C., Rio Ferreira C., Rolo Santos C., Rodrigues C. S., Allmer C., Bradshaw C. J., Rukundo C., Seneza C., Raphael C., Guldogan C. E., Bilir C., Hacialioglu C., Ersavas C., Ozkan C., Huaroto Landeo C. F., Ginesta C., Infante C., Pastas C., Ciubotaru C., Narayan C., Mahakalkar C., Floros C., Demiri C., Chatzinikolaou C., Dempers C., Ansah Larbi C., Banka C., Cini C., Dally C., Doku C., Ntow-Boahen C. K., Nicholson C., Cornwell C., Stennard C., Lionel C., Azmat C. E., Nyampinga C., Tandup C., Agarwal C., Parmar C., Pun C., Un C. W., Baars C. A., Celano C., Fumagalli C., Marafante C., Zandonella C., Nwanmah C., Osuigwe C., Nwokoro C., Nwosu C., Nwosu C. D., Lim C. K., Onyeka C., Uche C., Jamieson-Grigg C., Ong C. S., Alphonse C., Bode C., Varghese C., Carrillo Sarango C., Esteo Verdu C., Krautz C., Mosca C., Nimbona C., Nikolaou C., Wiesner C., Kloppers C., Kourouniotis C., Seiler C., Knee C., Mpirimbanyi C., Aboah C., Amah C., Cheong C., Harmston C., Leung C., Seet C., Smart C., Chouliaras C., Damaskos C., Doudakmanis C., Kaselas C., Limas C., Ntagkas C., Papazacharias C., Stefanou C., Thrasyvoulou C., Tsalikidis C., Karagianni C., Kolla C. -C., Ugwunne C., Ilo C., Nwegbu C., Onwuzu C., Weadick C., De Martino C., Donohoe C., Gutierrez De La Rosa C. E., Florian Villa C. M., Petcu C. 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N., Ofosuhene D., Hajela A., Badwan B., Kulkarni D., Dhawan D., Dhillon J., Mehmood M., Mahmood N., Nikam N., Ramchandani R., Thind R. S., Riazhussain D. H., Maqsood S., Alalawi Y., Tyagi H., Kshirsagar S., Ahmed H., Juan Carlos L. C., Kone D., Omar D., Alves D. G., Subasinghe D., Ommi D., Joshiba D., Chakarov D., Arkoh E. A., Frimpong-Manso E., Ada E., Lincango E. P., Lozada Hernandez E. E., Hodzic E., Di Marco E., Baccalini E. A., Baldini E., Gonzalez Marin E., Gutierrez E., Sepulveda E., Dainius E., Zhang E., Yenli E. M. T. -A., Antoniou E., Kapasakis E., Baili E., Poulios E., Kubiliute E., Osaze E., Afeikhena E., Elshennawy E., Athanasopoulou E., Synekidou E., Ekaladze E., Tampaki E. C., Adam E., Adel Hamdoun Aziz E., Yousuf E., Gialamas E., Spartalis E., Bedzhanyan E., Toma E. 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A., Younes E., Basile E., Gessa E., Pontecorvi E., Romairone E., Hatangimana E., Ndizeye E., Ciofic E., Dijan E., Lopez-Negrete Cueto E., Baker E., Reid E., Schmidt E., Alic E., Bicakcic E., Agbowada E., Colton E., Downing E., Haege E., O'Neill E., Roussos E., Nachelleh E. A., Adebunmi E., Obiesie E. A., Akakpo E. B., Konlan E. D. F., Nwangwu E. I., Kafui Ayodeji E., Ofori E. O., Spanoudakis E., Abate E., Balik E., Bozdag E., Bozkurt E., Karabulut E. C., Ozoran E., Tunccan E., Tuzuner E., Halilovic E., Alabed E., Zidan E., Aybar E., Yildirim E. O., Wong E., Yhoshu E., Bisogno E., Andolfi E., Ferri E., Potenza E., Spalice E., Volpin E., Gonzalez E., Downes E., Gallo E., Kamer E., Naidoo E., Erginoz E., Bara E., Irungu E., Garcia-Villegas E. Y., Mazzotta E., Monati E., Chan E., Gomez Mejia E., Dylja E., Somuncu E., Yavuz E., Begunic E., Margelis E., Osei E. O., Saitoglou E., Agastra E., Mazumdar E., Soyer Guldogan E., Abu Siam E. 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P., Peters F., Re F., Brucchi F., Casti F., Coratti F., Ferrara F., Floris F., Izzo F., Maffei F., Palmieri F., Pata F., Porcelli F., Selvaggi F., Velluti F., Mulita F., Bello F., Caiquo F., Dossou F., Eshun F. J., Opoku Twene F., Tierenye F., Quayson F. W., Romo Rosales F. D., Ibanez Ortiz F., Leon Frutos F. J., Redondo Calvo F. J., Silva Rivera F. J., Barbosa Camacho F. J., Bujalance Cabrera F. M., Ruescas F., Irakiza F. F., Corvatta F., Pascual F. R., Roviello F., Roodt F., Gyamfi F. E., Olaniru F., Owusu F., Bader F. G., Anzinger F. -X., Agbodo F. D. A., Ris F., Agbemafoh F. M., Afonso F., Nazareth F., Berrevoet F., Hounde F., Demiral F., Hassooni F. R. H., Kafa G., Cardenas Rivera G., Ntwari G., Szydlo Shein G., Ambriz Gonzalez G., Nita G. E., Bellio G., Moitzi G., Urdang G., Marom G., Gallo G., Luglio G., Poillucci G., Singh G., Saletta G., Abouelnagah G., Yarovenko G., Kazobinka G., Ahmed G. M. G., Rahman G. A., Smith G., Pillai G., Saxena G., Gbessi G., Nkunguzi G., Jalal G., Chillarge G., Mevognon G., Getachew G., George G., De La Pena Gonzalez G., Martinez Izquierdo G., Grande G., Birikorang G., Weber G. F., Singer G., Ansong G., Bashour G., Brown G. D., Hneino G., Kavalieratos G., Kenchadze G., Nagy G., Pappas Gogos G., Skroubis G., Waiyaki G., Cox G., Zeringa G., De Wee G., Hart G., Bekakos G., Fragulidis G., Kapogiannatos G., Karakaidos G., Kokkinos G., Kostoulas G., Koukoulis G., Peros G., Rados G., Tsoulfas G., Verras G. -I., Berger G., Adoro G. A., Chamoso Mialdea G., Palmieri G., Procaccini G., Steenkamp G., Viscido G. R., Dajti G., Alemayehu G., Seyfu G., Birqeeq G., Alsheikh G., Alrayyes G., El Hunjul G. N., Zaza G., Matroud G., Alhadwah G., Maltinti G., Awais G., Shamsi G., Calini G., Carganico G., Zanus G., Canu G. L., Mendiola G., Ibero Casadiego G. P., Cocorullo G., Baronio G., Pellino G., Zanni G., Poto G. E., Gravante G., Aduroja G., Almogy G., Bond-Smith G., Natchagande G., Bechara G., Brachini G., Riccioli G., Ercolani G., Farris G., Giraudo G., Mammolo G., Pavone G., Sgarzini G., Aprea G., Fonsi G. B., Boroni G., De Angeli G., De Palma G. D., Emiliani G., Grava G., Guercio G., De Carlo G., Del Corpo G., Duranti G., Galatioto G., Grassi G., Graziano G., Marini G. M. F., Munzi G., Tarantino G., Borda-Luque G., Pellicano' G. A., Canonico G., Carollo G., Ietto G., Palomba G., Pascarella G., Salamone G., Sica G., Sorrentino G., Orlando G., Pignata G., Pisarevi G., Akcakoca G., Owusu G., Yohanna Abrak G., Kurtoglu G. K., Kurtoglugk G. K., Alici G., Kurtoglu G. M., Delgado Hernandez G., Augustin G., Bhat G. A., Sundaram Venkatesan G., Chang G., Eke G., Lee G., Massarra G., Travaglini G., Scialandrone G., Stavrou G. A., Di Franco G., Charalambous G., Christodoulidis G., Kouraklis G., Goodwin G. R., Devidze G., Fialho G., Santos G., Cabezudo G., Garcia-Santos G., Pou G., Romero Reyna G., Yanowsky-Reyes G., Ozyuksel G., Karadeniz Cakmak G., Kucuk G. O., Bulbuloglu G. C., Sarp G., Kaur G., Nibogora G. D., Hamdan G., Ogundipe H., Yunes H., Ayesh H., Al Atassi H., Jalilehvand H., Masalma H., Jafarkhan H., Shahid H. H., Younus H., Al-Derume H., Shames H., Mimouni H. A., Aldare H., Odah Bashi H. O., Abusnina H., Altounsi H., Qayum H., Baysal H., Bolukbasi H., Yigitbas H., Alkhatib H., Afzal H., Mftah H., Oyinlola H., Tumer H., Dolo H., Braham H., Ozsahin H., Abu-Arish H., Al-Aamri H., Fadlalmola H. A., Abu Obead H., Al-Fahel H., Al-Zoubi H., Asaad H., Ejaz H., Jaber H., Bhatti H. W., Mohammadi Sardoo H., Farhat H., Idheiraj H., Zwaraa H., Al Sohabi H., Basharat H., Said H., Al-Abdallat H., Foad H., Daaboul H., Al Qadhi H., Elhallaq H., Alhusaini H., Lidbetter H., Reilly H., Moya-Ambriz H. B., Lederhuber H., Fehrer H. -J., Xiao H., Iswariah H., Kaur H., Cheema H. K., Foda H., Chauhan H., Sagar H., Unwin H., Panga H., Gupta H., Prabhakar H. K., Anand H., Pahwa H. S., Abbadi H., Amoudi H., Zaini H. H. Z., Skiljo H., Miyasika H., Altabbaa H., Haj Freej H., Abdelazim H., Habiba H., Kamal H., Sabir H., Zaigham H., Pehlivan H., Telci H., Abuobaida H., Tetley H., Taher H., Aguado Lopez H., Askarpour H., Sherif Farouk Ahmed Hassan H., Devesa H., Arbogast H., Nunez Del Barrio H., Abiyere H., Delacave H., Rice H. E., Pleass H., Bradly H., Islam H., Lule H., Abozied H., Le Roux H., Hamdar H., Yaghmour H., Bileid Bakeer H., Al Miskry H., Ulman H., Abdoun H., Essalim H., Yonekura H., Kato H., Amin-Tai H., Kynaston H., Perez Baca H. D. J., Irfan Khan H., Amir H., Elghadban H., Elfeki H., Wain H., Adjei H., Dabrowski H., Novak H., Alzuhd H., Capote H., Gomez-Fernandez H., Stark H., Willy-Chidire H., Aouagbe Behanzin H., Oneizah H. M. A., Dalati H., Ebied H., Mahajna H., Ahmad H., Altawati H., Adi H., Albalawi H., Alfakeer H., Embarek H., Ibrahim H., Malkawi H., Ekwuazi H., Psilopatis I., Wasiu I., Kereet I. M., Suleiman I., Fortune I., Aburumman I., Adel I., Adham I., Ali I., Arnaout I., Cakir I., Suleiman I. E., Fagiri I., Hajmohammed I., Ozata I. H., Kandil I., Ahmed I. M. G., Tagreda I., Garzali I. U., Nadi I., Ogundele I., Pius Ogolekwu I., Shariff I., Jakaityte I., Abdullah I., Babajimi-Joseph I., Guirguis I., Orji I., Okoro I., Ahmed I., Obianyo I., Njere I., Ugwueke I., Nzenwa I. C., Zerrouq I., Clementi I., Neri I., Yavuz I. E., Hoxhaj I., Fakhradiyev I., R Fakhradiyev I., Gomatos I., Fidoshev I., Gouazar I., Alnimer I., Boudis I. E., Boumakhlouf I. E., Abdalla I., Herrero I., Osman I., Nasser I., Singh I., P S I., Borges Da Costa I., Colaco I., Lourenco I. M., Mogarrio I., Konigsrainer I., Hamdun I. H. S., Tanase I., Bokos I., Contis I., Demiris I., Gerogiannis I., Gogoulis I., Karatsolis I., Katsaros I., Kozadinos I., Margaris I., Maroulis I., Papaconstantinou I., Siannis I., Sougkas I., Spyridakis I., Tierris I., Tsakiridis I., Imihteev I., Negoi I., Chatzis I., Shahbaz I., Didier I., Pipia I., Parwaiz I., Duran Sanchez I. I., Norman I., Bakaweri I. N., Santos I., Mylona I. C., De Haro Jorge I., Cervera I., Dajti I., Datji I., Matache I. M., Russo I. S., Aremu I. I., Amankwaa I., Caitens I., Esparza Estrada I., Mubezi I., Gascon Ferrer I., Serrano I., Dong I., Mondi I., Serfontein I., Rakshit I., Kyei I., Murshed I., Cabrera I., Abo Elhagag I., Alsoubie I., Lawani I., Bilgin I. A., Cholah I., Hamzaoglu I., Maharem I., Shehadeh I., Hagbevor I., Bahikoro I. W., Laopeamthong I., Mikulic I., Bacic I., Rakvin I., Separovic I., Vidic I., Conversano I., Mrazkova I., Yotsov I., Ilieva I., Coza I., Aljada I., Hussein I., Tesfahun I., Sadiq I., Martinez Martin Del Campo J. 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O., Omer M., Osman M., Zaazou M., Zahed Abdalla M., Melouane M. -S., Abed M., Sawaftah M. A. M., Al-Masri M., Al-Qannas M., Ali-Hassanzadeh M., Yunus M. A., Aloulou M., Alrantisi M., Araydah M., Bani Hani M., Barakat M., Durrani M., Khan M. F., Dwikat M. F., Hasan M., Nabhan M. H., Hijazi M., Abu Albahrain M. K., Barakat M. M., Mubarak M., Omar M., Pourfridoni M., Mslmani M. R., Salah M., Tanashat M., Yahmad M., Elmujtaba M., Abd Al-Fattah M., Abdelkabir M., Abosedra M., Sarker M. A. K., Abudabbous M., Abuwarda M., Elgak M. A., Al Hinai M., Al Zebda M., Al-Shehari M., Alharthi M., Ali M., Ismael Alamin M. A., Alqadasi M., Alshanwani M., Alshehri M., Asaad M., Bashir M., Bohlala M., Meghaizerou M. E. A., Albanna M. E. H., Ghunaim M., Goga M., Hajhamad M., Hamada Takrouney M., Hammoda M., Hamoud Almahly M., Muragi M., Mohammed M. M. H., Obaid M., Said M., Saleh Khatab M., Aliyu M. 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N., Roukounakis N., Stamos N., Tasis N., Tsakiridis N., Vlachakos N., Zampitis N., Kouzakos N., Borner N., Dimitriou N., Dafnios N., Banerjee N., Klammer N., Maharjan N., Rabai N., Oscar N., Harrison N., Kheyrbek N., Kansakar N., Bhat N., Krishnappa N., Pahuja N., Paul Ambrose N., Renovat N., Musawa N., Nwanne N., Steve N., Chidumije N., Nwafulume N., Celestine N., Duru N., Lopez Bernal N. E., Laquatra N., Pasqua N., Awwad N. A. -D., Ali N., Hielscher N., Trabulsi N., Huser N., Munoz Montes N., Eshak N. -S., Rajab N., Lahnaoui N., Ouachou N., Dadoush N., Fazili N., Theophile N., Ntanzi N., Bibila N. S., Alwaer N., Naabo N., Jiagge N., Freitas Oliveira N. M., Pratas N., Morricone N., Franco N. F., Binti Yusri N. A., Ramli N. N., Abd Ghani N. S., Umar N., Aly N. K., Lakhanov N., Al-Hroub N., Kiziltoprak N., Chavarrias N., Maulenov N., Akinbami N., Abdulraheem N. T., Karunaratne N., Jeannette N., Altobaishat O., Egwuonwu O. A., Enciu O., Cohen-Arazi O., Pheiffer O., Okoye O. 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K., Mashlah Q., Sabbah Q., Sethi R., Robitsek R. J., Jubran R. E., Raheem Attallah Al-obaidy R., Michael R., Abela R., Colbran R., Geow R., Titcombe R., Soglonou R., Ait Ben Addi R., Jayakrishnan R., Acharya R., Salim R., Guzman Lambert R., Donchev R., Drasovean R., Andreou R., Perez-Soto R. H., Santana Ortiz R., Villalobos Mori R., Sokratous R., Smolinski Kurek R. L., Solecki R., Basile R., Abd Elkareem R., Yousef Yassin R., Faisal R., Abd Alkareem R., Hegy R., Jaba'Teh R., Sharma R. D., Gupta R., Saxena R., Sinha R., Varshney R., Ripoll I Palmes R., Lunevicius R., Raghunath R., Redkar R., Sharma R., Philip Sridhar R., Krishna Raj R., Nathani R., Kottayasamy Seenivasagam R., Ahmed R., Handa R., Vakil R., Armah R., Attaf R., Elazary R., Alkhatib R., Alzu'Bi R., Raddad R., Kaur R., Nataraja R., Hussam Yacoub Hattar R., Ben Hmida R., Chaudhary R., Ramirez Calas R. 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N., Dawo S., Ng S., Nofal S., Ahmed S., Amahmid S., Elnoamany S., Fakhouri S., Selim S., Abrayik S., Di Saverio S., Kassad S., Carrabetta S., Costa S., Gargiulo S., Schirone S., Sorrenti S., Beavis S., Lawday S., Alananzeh S., Arafa S., Bani Amer S., Mamduh S., Omar S., Altaf S., Dos Santos Rocha Ferreira S., Quoy S., Emile S., Abu Salem S., Al Athath S., Yigman S., Eldirdiri S., Imam S., Jomaa S., Errami S., Kessab S., Muhammad S., Delibegovic S., Kanaan S., Aliozor S., Olori S., Sani S. A., Anim S., Bennett S., Debrah S., Ghattas S., Brenu S. G., Robinson S. J. A., Arthur S. J., Mcclintock S., Mensah S., Ogunlade S., Tingle S., Jabeen S., Borrego Canovaca S., De La Cruz Ahufinger S., Tsoti S. M., Paterna-Lopez S., Sanz S., Tsatsu S., Hugli S., Yunusa S. A., Aji S. A., Katragadda S., Edem S., Irrinki S., Shivashankar Chikkanayakanahalli S., Bertone S., Karmarkar S., Abbas S., Alashhab S., Alsaeiti S., Andrade S., Egreara S., Elfallah S., Galati S., Garcia Lopez S., Giovampietro S., Ismail S., Kamari S., Lauricella S., Marzorati S., Mohammed S., Moschella S., Mostafa Yassin S., Patrocinio S., Massa S. T., Vertaldi S., Abdelmohsen S., Al Sharie S., Barbosa Castelo Branco S., Bowman S., Condron S., Elfurdag S., Ellouzy S., Fennelly S., Mansour S., Molfino S., Qwyder S., Rennie S., Robinson S., Segnitome S., Staight S., Yassin S., Alsibai S., Khan S., Khurana S., Rafiq S., Malhi S. S., Dognia S., D A S., Babu S., Subbiah Nagaraj S., Meena S. P., Vasquez S., Bradulskis S., Mikalauskas S., Laura S. G., Verhage S. S., Simeonidis S., Sarwary S. H., Naidu S., Schimpke S., Davis S., Stevens S., Sierra S., Dos Santos S., Strachan S., Bektas S., Atupra S. A. A., Kreid S., Bugren S., Saudi-Moro S., Ashini S., Aboseif S., Abdul Rahman S. -A., Karim S., Ozturk S., Akuffo S., Awad S., Srishankar S., Tobome S. R., Malek S., Quartarone S., Grimaldi S., Guarriello S., Kalenga S., Katorkin S., Trujillo Ponce S. A., Villeda S. A., Intini S. G., Vazquez-Sanchez S. J., Salido S., Valeri S., Yilmaz S., Meric S., Bensalem S., Sucu S., Uludag S. S., Torres Rodriguez S. T., Ooi S., Luciano S., Houndji S. F. A., Agordjor S., Ward S., Samardali S., Altoume S., Mahfoud S., Razaq S., Husanov S., Islam S., Waqar S. H., Kumaran S., Magrhi S., Zhang S., Kashyap S., Karandikar S., Sundaramurthy S., Chowdhury S., Jayasekara S., Laura S., Shanker S., Ababneh S., Gilbert S., Kenworthy S., Ng S. H. M., Mackenzie S., Salindera S., Khattak S., Loke S. N., Manzoor S. V., Alwardi S., Allam S., Tawfik S., Francis S., Cai S., Dindyal S., Pandya S., Chopra S., Ingley S., Kulkarni S., Kosna S., Nayak S., Ahuja S., Hariharan S., Karuppusamy Krishnasamy S., Khare S., Handa S., Amin Omar Alsiddig S., Alqurashi S., Al-Tahayneh S. -A., Sibiya S., Perretta S., Ibarra Camargo S. A., Montisci S., Mungo S., Puddu S., Severi S., Agudelo Mendoza S. V., Makkai-Popa S. T., Boyes S., Monkhouse S., Stock S., Alberti S., Meneghini S., Giudici S., Guadagni S., Birolo S. L., Novello S., Oliveira S., Gumede S., Dhole S., Budhwani S. S., Ramjit S., Yumurtacilar S., Mahendra S. N., Abeykoon S., Moh Pauzi S. F., Rajendra S., Sundararajan S., Gananadha S., Kamarajah S. K., Marawu S., Basu S., Hassan S., Reddy S. M., Anaya Sanchez S., Gaspar Reis S., Gomez S., Gamba S. L., Pimentel Morais S., Ashry S., Abdullateef S., Bandyopadhyay S., Samadi S., Pathan S. R., Lakew S., Ohri S., Alonso Marcos S., Amoza Pais S., Fortuna Martins S., Gill S., Matthiess S., Sabbatini S., Soto Schutte S., Engel S., Eam S., Botaitis S., Lawani S., Jamil S., Kondpan S., Oum S., Govender S., Christodoulou S., Davakis S., Vernadakis S., Gkogkos S., Gobishangar S., Suresh S., Vembar S., M S., Abdelrasoul Elnour Ismail S., Zourntou S. -E., Nwabuoku S. E., Ideh S., Charitonos S., Liapis S. C., Faber S., Piccioni S. A., Romano S., Silvestre S., Jarmusch S., Soelling S., Cardelli S., Chaifouroosh Mamagany S., Corso S., Basso S. M. M., Megna S., Bitsianis S., Tsatsos S., Morales S., Gerdes S., Goller S., Hanna S., Tabiri S., Agana S., Theivendran S. A., Kache S., Knight S. R., Smith S., Stonelake S., Wrenn S., Gopaul S., Vederaki S., Kapiris S., Kykalos S., Hlaing S. S., Chia S. Y. D., Abu Khousa S., M. Udwan S., Raul S., Chase S., Nair S., Joseph S., Singh S. K., Singh S., Timmalah S., Alsuwiyah S., Thalgaspitiya S. P. B., Sellahewa S., Neogi S., Burger S., Polat S., Alkadi S., Asiri S., Otho S., Mewa Kinoo S., Ebrahim S., Tontus S., Midya S., Thuraisamy Sarma S. I., Payyanur Thotan S., Kumar Venkatappa S., Techapongsatorn S., Kaur S., Jp S., Tan S., Djote S. M., Surendran S., Chilaka S., Lee S., Henriques S., Giridaran S., Achugatla S., Kumar S., Brincat S., Deshpande S., Batista S., Akharaekpanya T., Moges T. G., Turkmen T. B., Alhaj Hasan T., Alshawabkeh T., Majed T., Lawal T. A., Ibiyeye T. T., Rashid T., Kosir Bozic T., Mohammed T., Khewater T., Abelman T., Al Barhi T., Mogne T., Salazar-Lorenzana T. A., Akter T., Gomez Sanz T., Motiwala T., Valizadeh Elizeh T., Almahdi T., Albushary T. A., Abdulrahman T., Finlay T., Chouari T., Awad T., Sabra T., M. Abubasheer T., Alhusban T., Yilmaz T. E., Aloqaili T., Aldirawi T., Karahasanoglu T., Gulsen T., Jemal T., Nadeem T., Singh T. P., Alinger T., Longkumer T., Lo T., Gimenez Maurel T., Uprak T. K., Petropoulou T., Rawther T., Techapongsatorn T., Manickam T., Padioti T., Kozonis T., Sidiropoulos T., Tsirlis T., Theodosopoulos T., Hessou T. K., Uiyapat T., Agyen T., Harris T., Hugh T. J., Jorgensen T. W., Theivendrampillai T., Pham T. V., Branco T., Nagwamutse T. N., Tony V T., Devabalan Koil T., Pilia T., Abdulmola T. M. A., Oyeyemi T., Kebede T., Ibarra-Hurtado T. R., Reichelt T., Gach T., Stefura T., Wojewoda T., Soric T., Risteski T., Tridip T. D. B., Yotsov T., Doma Bhutia T., Girma T., Kwan T. Y., Ivanov T., Iahmo T. T., Ashkar T., Mabogoane T., Olobatoke T., Sholadoye T. T., Mishra T. S., Parker T., Ezomike U., Dilibe U., Kumbhar U., Una U. -A., Grossi U., Ezidiegwu U., Edith U., Daspal U., Kalu U. A., Dietz U., Ronellenfitsch U., Wirth U., Abdullah U., Rivolta U., Jayarajah U., Kanyan Kassim U. -H., Govindan U., Fernandes U., Akram U., Mohammed Bello U., Omara U., Naidoo U., Mahendravarman V., Negoita V. M., Mariottini V., Murzi V., Zucchini V., Agbakwuru V., Armenta Tapia V. E., Gentilino V., Borgogni V., Ng V., Wolfschluckner V., Silvestri V., Zufic V., Gunasaegaram V., Kamalathevan V., Pillay V., Neykov V., Kalles V., Mousafeiris V., Papadopoulos V., Tsaousis V., Tselepidis V., Vougas V., Georgilaki V., Nikolaou V., Themelidi V., Manchev V., Ioannou V., Jha V. S., Dragisic V., Sutharshan V., Alonso V., Brocco V., Ongil Rodriguez V., Schirinzi V., Budyakova V., Naunova V., Panduro-Correa V., Ruiz Lopez V. A., Bill V., Dassah V., Gonzabay V. E., Etwire V., Modekwe V., Serna-Alarcon V., De Donato V. U., Duque Mallen V., Liu V., Sharma V., Kumar V., Muralidharan V., Kakotkin V., Enemuo V., Kudoh V., Osoka V., Siepaal V., Granata V., Dinuzzi V. P., Lizzi V., Ricchiuti V., Mosca V., Kanna D V., Nair V. V., Ledda V., Michael V., Singh V., Govindasamy V., Kollengode V. V., Giordano V., Morinelli V., Lin V., Cuk V., Cijan V., Calik V., Bakshi V., Ten V., Ratheesh V., Alsado W., Mayo W., Yang W., Rehman W. U., Abbas W., Al-Khyatt W., Mabood W., Santucci W., Yew W. T., Tahir W., De Silva W. D. D., Wijenayake W., Almadhoun W. J. N., Alhroub W., Ebrahim W., Jablonski W., Krawczyk W., Bhatti W., Lai W. K. H., Petrushnko W., Afedo W., Kasetsermwiriya W., Serednicki W., Wysocki W., Zerefa W. A., Vagena X., Tarrado X., Papazarkadas X., Po X. Y., Ouadi Y., Myla Y., Haido Y., Hasan Y., Karatas Y., Carpio Colmenares Y., Galvan Felix Y., Balogun Y. L., Maktabi Y., Nerabani Y., Fulgence Y., De Silva Y., Asar Y., Samer Morsy Y., Ghaleb Y. S. S. M., Vashishth Y., M S Y., Manickchund Y., Sakaray Y., Kara Y., Tosun Y., Zwain Y., Farag Y., Jedidi Y., Seada Y., Aldebasi Y., Ashour Y., Badr Y., Sarpong Y., Alawneh Y., Aung Y. L., Orabi Y., Lam Y. H., Sen Y. K., Koyluoglu Y. O., Huang Y., Mintz Y., Perez Y., Chamara Y., Melkamu Y., Maestre Gonzalez Y., Dean Y., Metaferia Y. Y., Malki Y., Mohamed Y., A. Omar Y., Alhammoud Y., Allaoua Y., Tanas Y., El Okazy Y., Kerolous Y., Al-Junaidi Y., Lakdawala Y., Lu Y., Asano Y., Altinel Y., Aktimur Y. E., Fishman Y., Kudryavcev Y., Tandogan Y. I., Razafimandimby Y. M., Adofo-Asamoah Y., Senol Z., Odeh Z., Benamrouche Z. R., Alkhaier Z., Al-Sheikh Ali Z., Zaher Z. A., Alnajjar Z., Al-Balushi Z., Alkhuzaie Z., Khraim Z., Toutounji Z., Djama Z., Farraj Z., Shah Z. A., Khan Z., Abo Alarous Z. A., Asaad Z., Demetrashvili Z., Lorenc Z., Brekalo Z., Hannouneh Z. A., Robertson Z., Bady Z., Durna Z., Wong Z. Y., Fozo Z. A., Klib Z., Chin Z., Tamou Z. F., Johnson Z., Shabello Z., Orzeszko Z., Aljalabi Z., Al-Azher El-Hamel Z., Karampotaki Z. R., Valera Sanchez Z., Matkovic Z., Azhar Z., Qureshi Z., Correa Lopez Z. M., Balciscueta Z., Musilova Z., Katusic Z., Osama Z., Dauksa Z., Donmez, A, Goswami, A, Raheja, A, Bhadani, A, El Kady, A, Alniemi, A, Awad, A, Aladl, A, Younis, A, Alwali, A, Khalil, A, Mansour, A, Elkhouly, A, Rashad Temerik, A, Hasan, A, Chied, A, Abdraba, A, Hrora, A, Abdelshafi, A, Maraqa, A, Ghaffar, A, Chekfa, A, Al Balushi, A, Quddus, A, Hammadieh, A, Muntaka, A, Asekun, A, Alshahrani, A, Jowharji, A, Alshukre, A, Khair Etareig, A, Abubakar Abdulkarim, A, Ashiru, A, Alailesh, A, Al-Mallah, A, Baydoun, A, Chaudhry, A, Askin, A, Almutairi, A, Belkhair, A, Abdllah, A, Alhammali, A, Basalim, A, Abouelnagah, A, Ghazal, A, Mohammed, A, Qasem, A, Anadani, A, Jimoh, A, Lawal, A, Khaity, A, Elzoubi, A, Sheshe, A, Cetisli, A, Oyedele, A, Aljahdali, A, Aboelnasr, A, Demessie, A, Bhargava, A, Sonkar, A, Bavaharan, A, Khan, A, Campbell, A, Oyelekan, A, Okunlola, A, Ojewuyi, A, Ekerin, A, Saleh, A, Khairy, A, Muthunayagam, A, Botha, A, Teshome Sahilemariam, A, Nawawi, A, Muhammad, A, Dahiru, A, Yahaya, A, Abdelmalik, A, Anuar, A, Ousseini, A, Leon -Del- Angel, A, Frankel, A, Gyedu, A, Lim, A, Lukac, A, Peckham-Cooper, A, Sabbah, A, Varga, A, Sanou, A, Issaka, A, Ningi, A, Yeshitila, A, Yingess, A, Olugbami, A, Damola-Okesiji, A, Ojo, A, Hashmi, A, Fakoya, A, Ishola, A, Abiodun, A, Ajayi, A, Mouffokes, A, Bonelli, A, Adekoya, A, Akeem Aderogba, A, Ozcan, A, Ayoade, A, Adeyeye, A, Agbaje, A, Talabi, A, Ademuyiwa, A, Adewumiya, A, Aderounmu, A, Adisa, A, Oke, A, Ragab, A, Alzadjali, A, Baksi, A, Jayapalan, A, Md Yunos, A, Pisanu, A, Salazar, A, Salinas Barragan, A, Fox, A, Stollberg, A, Franco, A, Neves, A, Vricheva, A, Hodonou, A, Aghayeva, A, Liaquat, A, Alsultan, A, Morad, A, Kalidis, A, Gkouniaroudi, A, Karakosta, A, Lovi, A, Yevide, A, Duro, A, Rodriguez Gonzalez, A, Tariq, A, Abaidalla, A, Abuhammad, A, Abuhantash, A, Ahmad Zaidi, A, Alahmad Alismael, A, Alayed, A, Alfarwan, A, Alhaj, A, Ali, A, Alroobi, A, Alsheikh, A, Alusef, A, Alzu'Bi, A, Kayali, A, Bouhuwaish, A, Doghaim, A, El-Sherbiney, A, Ramly, A, Raza, A, Qureshi, A, Arnaout, A, Abdelhamid, A, Abuthaher, A, Adel, A, Ahmayda, A, Al-Mouahhed, A, Alagha, A, Albalawi, A, Albhaisi, A, Alrifaee, A, Azam, A, Barakat, A, Al-Hajjaj, A, Dawoud, A, El Shamarka, A, El-Bastwesy, A, Elghrieb, A, Elkhalifa, A, Elmosalamy, A, Elshazli Mahmoud, A, Montaser, A, Gbeadese, A, Haty, A, K. Ali, A, Kedwany, A, Khalleefah, A, Abbas, A, Allam, A, Maher, A, Elsayed, A, Mohamed Ibrahim Mohamed, A, Mostafa, A, Nabil, A, Nada, A, Ragheb, A, Abdelrahman, A, Sabry, A, Sakr, A, Elkhodary, A, Shaheen, A, Ammar, A, Hameed, A, Akmercan, A, Aslan, A, Barcin, A, Ciftci, A, Bozkurt, A, Sari, A, Yasar, A, Develioglu, A, Ozturk, A, Sanli, A, Rencuzogullari, A, Yildiz, A, Kaan, A, Toi, A, Aljamoudi, A, Cheung, A, Gkoutoula, A, Kalogeropoulou, A, Sarafi, A, Abo Al Shamat, A, Sanon, A, Hiller, A, Costas-Chavarri, A, Lombardero, A, Fraile, A, Bojazyah, A, Kamal, A, Gill, A, Hada, A, Gulla, A, Maciulaityte, A, Sukumar, A, Landaluce-Olavarria, A, Sainz Lete, A, Pal, A, Malik, A, Horiguchi, A, Kocaay, A, Akinkuolie, A, Olabode, A, Fadipe, A, Akinmade, A, Darkwa Boateng, A, Appiah-Kubi, A, Alkaseek, A, Kadamani Abiyomaa, A, Anand, A, Oppong, A, Opoku-Agyapong, A, Asharaf, A, Ahmed, A, Andani, A, Alkharusi, A, Abd Elsattar, A, Alragheai, A, Alsalahat, A, Hawarah, A, Aldirani, A, Shabkah, A, Nixon Fulli, A, Nguyen, A, Mustafa, A, Joseph, A, Huws, A, Aregawi, A, Sanchez Gallego, A, Torroella, A, Vazquez Melero, A, Dauksa, A, Abreu Da Silva, A, Brun-Peressut, A, Barranquero, A, Gegundez Simon, A, Gerundo, A, Navarrete-Peon, A, Viacava, A, Vilar, A, Adam, A, Jarimba, A, Johnson, A, Nunez Venzor, A, Gonzalez Ojeda, A, Romero De Diego, A, Karamarkovic, A, Butyrskii, A, Edmundson, A, Sidorova, A, Thomas, A, Tomazic, A, Giuliani, A, Iodice, A, Marano, A, Marello, A, Ongaro, A, Saba, A, Anastasi, A, Borello, A, Broglia, A, Carta, A, Finocchio, A, Francia, A, Iacomino, A, Izzo, A, Ottaiano, A, Spaziani, A, Strumia, A, Biancafarina, A, D'Ignazio, A, Davolio, A, Morello, A, Licciardello, A, Mazzoni, A, Wilkins, A, Arekhandia, A, Barlas, A, Chamzin, A, Demetriou, A, Giakoustidis, A, Kozadinos, A, Kyriakidis, A, Sarakatsanos, A, Rojas, A, Saridaki, A, Litchinko, A, Arnaud, A, Binder, A, Yakubu, A, Kavalakat, A, Shamsutdinova, A, Alberico, A, Amendola, A, Sanchez-Teran, A, Lapergola, A, Baiden Amissah, A, Konigsrainer, A, Twumasi, A, Alhebshi, A, Abdul Rahman, A, Abidali, A, Abu Tair, A, Ahmad, A, Al Mukhtar, A, Sharq, A, Alloush, A, Amaigl, A, Kheirkhah Vakilabad, A, Bassma, A, Hacioglu, A, Elzanaty, A, Fani, A, Farsi, A, Ghummied, A, Hajali, A, Al Sharqi, A, Hammed, A, Hewari, A, Isler, A, Marouf, A, Uysal, A, Murtada, A, Syed, A, Ozkomec, A, Sapmaz, A, Wassouf, A, Aldurssi, A, Polatbekov, A, Caltagirone, A, Gori, A, Bhatt, A, Maxwell, A, Kiyabayev, A, Eltayeb, A, Khamees, A, Abdalla, A, Pikarsky, A, Trigos Diaz, A, A Elhars, A, Alhaj Zain, A, Eltahir, A, Robin Valle De Lersundi, A, Sanad, A, Abdalhadi, A, Sparke, A, Maqsood-Shah, A, Ouachhou, A, Kezze, A, Dawson, A, Mohsen, A, Brar, A, Dembele, A, Tansawet, A, Obbeng, A, Chiappini, A, Davis, A, Awidan, A, Tibude, A, Shah, A, Hilder, A, Huremovic, A, Alamin, A, Egdeer, A, Gharib, A, Choudhary, A, Amin, A, Ibrahim Hassan, A, Rashid, A, Patel, A, Sebai, A, Asla, A, Ghanbari, A, Shweiki, A, Tursunovic, A, Aboshosha, A, Elbalal, A, Abdelhalim, A, Gupta, A, Sinha, A, Al-Fandi, A, Awwad, A, Belaid, A, Khatib, A, Al-Zubeidy, A, Niazi, A, Zamareh, A, Salam, A, Ayodele, A, Al Hammoud, A, Khouli, A, Crowe, A, Surkitt, A, Alshiteewi, A, Alvarez Cuinas, A, Cabral, A, Dupont, A, Faustino, A, Carreira-Marques, A, Preto Barreira, A, Minaya Bravo, A, Pinheiro Pereira, A, Minaya-Bravo, A, Lourenco, A, Mateus Loureiro, A, Sanchez Gollarte, A, Tvaladze, A, Veira, A, Perja, A, Dusabimana, A, Herewini, A, Fatima, A, Zafar, A, Bangar, A, Kutma, A, Mehta, A, Alqerem, A, Jaber, A, Mourtzouni, A, Theochari, A, Zarafidou, A, Smyrnis, A, Tsechpenakis, A, Zakaria, A, Cardoso Almeida, A, Pita, A, Torbey, A, Abreu, A, Barberis, A, Bartalini Cinughi De Pazzi, A, Belli, A, Sironi, A, Damigella, A, Manetti, A, Mingoli, A, Natili, A, Police, A, Razzore, A, Scacchi, A, Vazquez Fernandez, A, Luzzi, A, Brosin, A, Efstathiou, A, Kirschniak, A, Panagakis, A, Pilavas, A, Scheiwiller, A, Skarpas, A, Chitul, A, Trif, A, Ferreira, A, Silva, A, Subocius, A, Cembellin, A, Garcia Marin, A, Ang, A, Gray, A, Li, A, Skreka, A, Abdul Rahim, A, Bhangu, A, Moncy, A, Mwanjoka, A, Fernandez Camunas, A, De Jesus Gil, A, Molero, A, Sultana, A, Suarez Alvarez, A, Nava Franco, A, Autiak Ayii Chol, A, Serao, A, Nikolaou, A, Hassanin, A, Evans, A, Vu, A, Lala, A, Luther, A, Sundaram, A, Cerovac, A, Abgeko, A, Agbeko, A, Sharma, A, Jain, A, Attili, A, Alecci, A, D'Amore, A, Domenech Plana, A, Gut, A, John, A, Lareida, A, Pesce, A, Paspala, A, Sharp, A, Victor, A, Comandatore, A, Olsen, A, Yiallourou, A, Loizou, A, Asare Twumasi, A, Davor, A, Tabiim, A, Lin, A, Szpytko, A, Walfor, A, Oosterkamp, A, Kachi, A, Khoneisser, A, Bediako Bowan, A, Sumbaev, A, Deserra, A, Punzengruber, A, Thanasa, A, Azzinnaro, A, Castaldi, A, Curado Soriano, A, Garcia Dominguez, A, Lai, A, Martinez German, A, Masciandaro, A, Miele, A, Ramirez Beas, A, Ramos Bonilla, A, Ramos-De la Medina, A, Zerbinati, A, Athanasiou, A, Panagidis, A, Vezakis, A, Boynes, A, Mishra, A, Singh, A, Appukuttan, A, Alhamadi, A, Gusibat, A, Seidu, A, Fuertes Munoz, A, Shanker, A, Balta, A, Panagopoulos, A, Roslani, A, Tahir, A, Hernandez, A, Roumieh, A, Pinto, A, Khanduri, A, Isik, A, Dhinakar, A, Ioannidis, A, Tsiaka, A, Balconi, A, Petrungaro, A, Narin, A, Plastiras, A, Papadopoulos, A, Kontokostopoulos, A, Bang, A, Nikitaras, A, Akiba, A, Jindal, A, Bedzhanyan, A, Fajardo, A, Antinori, A, Galvan, A, Belarmino, A, Mathew, A, Pillai, A, Alrababah, A, Shoker, A, Hai, A, Bhatti, A, Nair, A, Prasath S V, A, Krishna, A, Abdulnabi, A, Aboumedian, A, Faisal, A, Haidar, A, J, A, Choudhry, A, Albager, A, Jha, A, Chhabra, A, Choudhrie, A, Kumar, A, Tirkey, A, Oommen, A, Al-Bahla, A, Bakri, A, Maghrabi, A, Mahendran, A, Das, A, Eisa, A, Comella, A, Shanmugalingam, A, Boztas Demir, A, Zubillaga-Mares, A, Altawaiha, A, Mitsala, A, Katsiou, A, Bakalis, A, Marinis, A, Migdanis, A, Soumpasis, A, Syllaios, A, Tampakis, A, Cakmak, A, Rahman, A, Suroy, A, L'Hostis, A, Parseliunas, A, Rakotondrainibe, A, Goliath, A, Arustamyan, A, Sukhdev Jadhav, A, Chaudhary, A, Denz, A, Al Kaddah, A, Alaqtash, A, Ehab, A, Essamei, A, Kelzia, A, Farrag, A, Myintmo, A, Bibi, A, Iqbal, A, Irshad, A, Sinjab, A, Izgis, A, Almugaddami, A, Albatanony, A, Ayeni, A, Williams, A, Abunemer, A, Benmansour, A, Nidali, A, Vig, A, Emran, A, Ekpeti, A, Janjua, A, Fathi, A, Alzahrani, A, Rehmani, B, Ayoade, B, Mustapha, B, L, B, Alsharari, B, Balaravi Pillai, B, Balagobi, B, Mohamad, B, Ibrahim, B, Ali, B, Alqahtani, B, Paul, B, Yigit, B, Reverien, B, Dweik, B, Yacoub, B, Alzoubi, B, Chkir, B, M. J. Alhaj, B, Binda, B, Carvalho, B, Demurtas, B, Dieck, B, Freire, B, Gama, B, Habrat, B, Tinoco, B, Hernandez Cervantes, B, East, B, Maguire, B, Mckay, B, Zaczek, B, Dawud, B, Allbakosh, B, Yunusa, B, Aminu, B, Ibi, B, D'Souza, B, Alazabi, B, Algettawi, B, Sharaf Eldin, B, Hameed, B, Abboud, B, Al Soudi, B, Fahmy, B, Ranjous, B, Bereket Araya, B, Eyduran, B, Alsaid, B, Guerra, B, Markowska, B, De Zolt Ponte, B, Robertson-Jones, B, Sperotto, B, Cordeiro, B, Cuneo, B, De Andres-Asenjo, B, Louro, B, Estraviz, B, Khan, B, Abdennour, B, Calcano, B, Kigwe, B, Boakye, B, Agca, B, Togay, B, Esposito, B, Chiman, B, Lulham-Robinson, B, Martin, B, Peter, B, Ozcan, B, Seshie, B, Maanikuu, B, Lopes Patricio, B, Khattab, B, Johnson, B, Mcdermott, B, Neall, B, Wang, B, Roopavathan, A, Fosh, B, Sarang, B, Sv, B, R Budihal, B, Devkaran, B, Van Zyl, B, Kharga, B, Al-Sarireh, B, Duman, B, Baca, B, Down, B, Mengesha, B, Owusu Ansah, B, Radja, B, Sime, B, Capdevila Vilaro, B, Izedomi, B, Hao, B, Nimako, B, Phakathi, B, Sehgal, B, Cakpo, B, Alrayes, B, Mao, B, Bogdan-Gabriel, B, Bengaly, B, Williams, B, Cismasiu, B, Helou, B, Davies, B, Arya, B, Cirillo, B, Nardo, B, Pinto, B, Scotto, B, Vieira, B, Kadir, B, Albaihani, B, Calik, B, Citgez, B, Celik, B, Azhar, B, Alshaikh, B, Kum, B, Killoran, C, Nwachukwu, C, Hidalgo Salinas, C, Brasset, C, Bertoglio, C, Vasquez Maya, C, Zapata Syro, C, Akgun, C, Yurttas, C, Semeraro, C, Lategan, C, Boven, C, Uwakunda, C, Leal Ferrandis, C, Margiani, C, Piras, C, Samojeden, C, Vitiello, C, Feo, C, Boto, C, Roman Ortega, C, Ferreras Garcia, C, Figueiredo, C, Garcia-Salas, C, Gonzalez, C, Gonzalez Baez, C, Gracia-Roche, C, Guijarro Moreno, C, Hernandez Diaz, C, Ferrero, C, Perez Rivera, C, Jezieniecki, C, Perez - Padron, C, Leon-Espinoza, C, Nuno-Guzman, C, Macedo Cardoso De Oliveira, C, Shiraishi Zapata, C, Yanowsky-Gonzalez, C, Sorrentino, C, Tung, C, Cardoso, C, Chavarria Noya, C, Coutinho, C, Korzin, C, Maya, C, Moreno-Licea, C, Panis, C, Righetti, C, Silva, C, Soares-Aquino, C, Golliez, C, Chiam, C, Kamphues, C, Rahantasoa Finaritra, C, Assis, C, Henriques, C, Quintela, C, Rio Ferreira, C, Rolo Santos, C, Rodrigues, C, Allmer, C, Bradshaw, C, Rukundo, C, Seneza, C, Raphael, C, Guldogan, C, Bilir, C, Hacialioglu, C, Ersavas, C, Ozkan, C, Huaroto Landeo, C, Ginesta, C, Infante, C, Pastas, C, Ciubotaru, C, Narayan, C, Mahakalkar, C, Floros, C, Demiri, C, Chatzinikolaou, C, Dempers, C, Ansah Larbi, C, Banka, C, Cini, C, Dally, C, Doku, C, Ntow-Boahen, C, Nicholson, C, Cornwell, C, Stennard, C, Lionel, C, Azmat, C, Nyampinga, C, Tandup, C, Agarwal, C, Parmar, C, Pun, C, Un, C, Baars, C, Celano, C, Fumagalli, C, Marafante, C, Zandonella, C, Nwanmah, C, Osuigwe, C, Nwokoro, C, Nwosu, C, Lim, C, Onyeka, C, Uche, C, Jamieson-Grigg, C, Ong, C, Alphonse, C, Bode, C, Varghese, C, Carrillo Sarango, C, Esteo Verdu, C, Krautz, C, Mosca, C, Nimbona, C, Nikolaou, C, Wiesner, C, Kloppers, C, Kourouniotis, C, Seiler, C, Knee, C, Mpirimbanyi, C, Aboah, C, Amah, C, Cheong, C, Harmston, C, Leung, C, Seet, C, Smart, C, Chouliaras, C, Damaskos, C, Doudakmanis, C, Kaselas, C, Limas, C, Ntagkas, C, Papazacharias, C, Stefanou, C, Thrasyvoulou, C, Tsalikidis, C, Karagianni, C, Kolla, C, Ugwunne, C, Ilo, C, Nwegbu, C, Onwuzu, C, Weadick, C, De Martino, C, Donohoe, C, Gutierrez De La Rosa, C, Florian Villa, C, Petcu, C, Cecconi, C, Banal, C, Brandi, C, Hossu, C, Onuoha, C, Osime, C, Shelton, C, Fuentes Orozco, C, Adumah, C, Dina, C, Nastos, C, Aguero, C, Markin, C, Hoogerboord, C, Da Lio, C, Saviello, C, Bezede, C, Distefano, C, Elliot-Wilson, C, Bokossa, C, Lupercio Figueroa, C, Riboni, C, Meola, C, Costa, C, Gas, C, Larotonda, C, Soddu, C, Vacca, C, Vera Mansilla, C, Li, C, Agbonrofo, C, Akli-Nartey, C, Molewa, C, Nelly Rosine, C, Rega, D, Koike, D, Wickramasinghe, D, Clarke, D, Fry, D, Hannedige, D, Powell, D, Kasasbeh, D, Samardali, D, Sharl Ajami, D, Badran, D, Adjei, D, Muhie, D, Perez Munoz, D, Alifoe, D, Aparicio-Lopez, D, Banos Mendez, D, Cristian, D, Eaton, D, Gero, D, Makary, D, Montwedi, D, Munoz, D, Patterson, D, Reim, D, Agbley, D, Patino Garcia, D, Di Pietrantonio, D, Pais, D, Rosado, D, Tavares, D, Alberti, D, Fusario, D, Massaro, D, Paglione, D, Pironi, D, Kurochka, D, Centonze, D, Hackner, D, Herrera, D, Amangaliyev, D, Silva-Cano, D, Chaudhry, D, Palmisano, D, Ribero, D, Vukosav, D, Misca, D, Lowen, D, Rattray, D, Walia, D, Maan, D, Muyenzi, D, Verdi, D, Bardsley, D, Reyes Rodriguez, D, Fra Corral, D, Garcia Lopez De Goicoechea, D, Gavit, D, Gomez, D, Idowu, D, Konkin, D, Labadah, D, Liu, D, Merlini, D, Mitchell, D, Moro-Valdezate, D, Osifo, D, Proud, D, Ridder, D, Gobatti, D, Muschitiello, D, Pertile, D, Zulian, D, Mengiste, D, Mikami, D, Mohanty, D, Chatterjee, D, Komolafe, D, Scotto Di Carlo, D, Wright, D, Rahme, D, Talreja, D, Jain, D, Rajput, D, Singh, D, Anbu, D, Ibrahim, D, Phom, D, Hili, D, Osei, D, Daary, D, Kyeremeh, D, Shen, D, Uymaz, D, Cianflocca, D, Ashitey, D, Evripidou, D, Papageorgouli, D, Kaushal, D, Abeysirigunawardana, D, Dugar, D, Mallik, D, Ghosh, D, Houmran, D, Abdulrahman, D, Pantoja Pachajoa, D, Cardona Gomez, D, Fenner, D, Gonzalez, D, Siriwardena, D, Garces Palacios, D, Stoian, D, Zuikyte, D, Sosa Mendez, D, Wickramarathna, D, Mutter, D, Palma Portillo, D, Chavez Fernandez, D, Cordova Garcia, D, Enjuto, D, Giulitti, D, Sasia, D, Visconti, D, Yigit, D, George, D, Rabaia, D, Georgiev, D, Hadzhiev, D, Alexandrou, D, Balalis, D, Giakoustidis, D, Manatakis, D, Korkolis, D, Lytras, D, Massaras, D, Moris, D, Politis, D, Sampanis, D, Schizas, D, Tsiardas, D, Vardakostas, D, Kotsaris, D, Khattab, D, M. Awad, D, Alrokh, D, Schippers, D, Waleed, D, Salinovic, D, Goncalves Murias Gomes, D, Silva, D, Vaz Acosta, D, Morton, D, Panagopoulos, D, Kelgiorgi, D, Dellaportas, D, Prevezanos, D, Joshi, D, Ozal, D, Chimkaomasiri, D, Jabbar, D, Nepogodiev, D, Belekar, D, Abdalaziz, D, Abunemer, D, Attia, D, Elkafrawy, D, Dimitrov, D, Pignatelli, D, Merlicco, D, Soriero, D, Zerbo, D, Atouguia, D, Fairbrass, D, T. Enti, D, Venskutonis, D, Rukavina, D, Caruso, D, Herappe, D, Lee, D, Ofosuhene, D, Hajela, A, Badwan, B, Kulkarni, D, Dhawan, D, Dhillon, J, Mehmood, M, Mahmood, N, Nikam, N, Ramchandani, R, Thind, R, Riazhussain, D, Maqsood, S, Alalawi, Y, Tyagi, H, Kshirsagar, S, Ahmed, H, Juan Carlos, L, Kone, D, Omar, D, Alves, D, Subasinghe, D, Ommi, D, Joshiba, D, Chakarov, D, Arkoh, E, Frimpong-Manso, E, Ada, E, Lincango, E, Lozada Hernandez, E, Hodzic, E, Di Marco, E, Baccalini, E, Baldini, E, Gonzalez Marin, E, Gutierrez, E, Sepulveda, E, Dainius, E, Zhang, E, Yenli, E, Antoniou, E, Kapasakis, E, Baili, E, Poulios, E, Kubiliute, E, Osaze, E, Afeikhena, E, Elshennawy, E, Athanasopoulou, E, Synekidou, E, Ekaladze, E, Tampaki, E, Adam, E, Adel Hamdoun Aziz, E, Yousuf, E, Gialamas, E, Spartalis, E, Bedzhanyan, E, Toma, E, Dauksaite, E, Desiato, E, Dvivedi, E, Hadzhieva, E, Marti Cunat, E, Montalban Martinez, E, Montanari, E, Signaroli, E, Efremidou, E, Gavriil, E, Karakeke, E, Mavrodimitraki, E, Papamattheou, E, Jose, E, Cianci, E, Ciccioli, E, Daleva, E, Locci, E, Lori, E, Silanos, E, Ayala, E, Bankart, E, Brolese, E, Efstathiou, E, Salloum, E, Colak, E, Terzi, E, Ametefe, E, Cagigal Ortega, E, Donnarumma, E, Mina, E, Reitano, E, Wallner, E, Moggia, E, Betz, E, Kontis, E, Anestiadou, E, Gimson, E, Lun, E, Fraser, E, Li, E, Torres De Anda, E, Murphy, E, O'Connell, E, Redondo, E, Francis, E, Haiden, E, Hamed, E, Alkhalifa, E, Dexter, E, Daketsey, E, Setsoafia, E, Mohamed, E, Mohammed, E, Hegab, E, Ay, E, Adinolfi, E, Mbanzabugabo, E, Chin, E, Ahmed, E, Younes, E, Basile, E, Gessa, E, Pontecorvi, E, Romairone, E, Hatangimana, E, Ndizeye, E, Ciofic, E, Dijan, E, Lopez-Negrete Cueto, E, Baker, E, Reid, E, Schmidt, E, Alic, E, Bicakcic, E, Agbowada, E, Colton, E, Downing, E, Haege, E, O'Neill, E, Roussos, E, Nachelleh, E, Adebunmi, E, Obiesie, E, Akakpo, E, Konlan, E, Nwangwu, E, Kafui Ayodeji, E, Ofori, E, Spanoudakis, E, Abate, E, Balik, E, Bozdag, E, Bozkurt, E, Karabulut, E, Ozoran, E, Tunccan, E, Tuzuner, E, Halilovic, E, Alabed, E, Zidan, E, Aybar, E, Yildirim, E, Wong, E, Yhoshu, E, Bisogno, E, Andolfi, E, Ferri, E, Potenza, E, Spalice, E, Volpin, E, Gonzalez, E, Downes, E, Gallo, E, Kamer, E, Naidoo, E, Erginoz, E, Bara, E, Irungu, E, Garcia-Villegas, E, Mazzotta, E, Monati, E, Chan, E, Gomez Mejia, E, Dylja, E, Somuncu, E, Yavuz, E, Begunic, E, Margelis, E, Osei, E, Saitoglou, E, Agastra, E, Mazumdar, E, Soyer Guldogan, E, Abu Siam, E, Abdelbaset, E, Abdu, E, Adel Mahmod Sultan, E, Nubi Mohamed, E, Abuobaida Banaga Hag El Tayeb, E, Ali, E, Page-Taylor, E, Marra, E, Garcia Santos, E, Elsheikh, E, Unal, E, Tan, E, De Leo, E, Borges, E, Gaspar, E, Ruiz-Daum, E, Apostolopoulos, E, Samara, E, Barkolias, E, Fradelos, E, Hopping, E, Romo Ascencio, E, Sosa Ferreira, E, Shestakov, E, Tyurina, E, Hristova, E, Efthymiou, E, Tokidis, E, Harrison, E, Dontoh, E, Mansour, E, Yeshialem, E, Dabbagh, E, Amer, E, Manasci, F, Gomes, F, Medas, F, D'Acapito, F, Vassallo, F, Haddad, F, Elhabishi, F, Akhtar, F, Tauheed, F, Al Abbood, F, Gareb, F, Ghazali, F, Alnazawi, F, Ondago, F, Rasoaherinomenjanahary, F, Wiese, F, Gonzalez Ponce, F, Georgiades, F, Ali, F, Galley, F, Huda, F, Amir, F, Ashraf, F, Alfarsi, F, Ayasra, F, Mahmoud, F, Aliskander, F, Tahir Lwdie, F, Buyuker, F, Aguilar Del Castillo, F, Mohammed Daoud, F, Alowjaly, F, Oni, F, Rauf, F, Elkhafeefi, F, Hourri, F, Monib, F, Alshreef, F, Benghalbon, F, Ntirenganya, F, Chahrour, F, Ahmad, F, Parray, F, Philips, F, Campus, F, Di Marco, F, Ferraina, F, Frongia, F, Maffeis, F, Natali, F, Pederiva, F, Scolari, F, Tofani, F, Marin, F, Biolchini, F, Cappellacci, F, Corronca, F, Mazzola, F, Suldrup, F, Nyarko, F, Casas J, F, Zapata, F, Aigner, F, Alakaloko, F, Amoako, F, Camacho, F, Hammett, F, Kuubetersob, B, Alahmad, F, Alnimri, F, Gool, F, Castro, F, Diaz, F, Lucero, F, Vovola, F, Mahnic, F, Mercado Sanchez, F, Prieto La Noire, F, Soggiu, F, Tsige, F, Brzeszczynski, F, Rudisch, F, Valente Costa Pinto, F, Ramalho De Almeida, F, Banchini, F, Palomino Escalante, F, Fadzlullah, F, Terefe, F, Sulo, F, Ciccarone, F, Tirelli, F, Kramer, F, Grama, F, Spanos, F, Solimene, F, Akinwande, F, Osman, F, Stefou, F, Kyramargios, F, Stavratis, F, Alassani, F, Ascari, F, Cammelli, F, D'Agostino, F, Tropeano, F, Peters, F, Re, F, Brucchi, F, Casti, F, Coratti, F, Ferrara, F, Floris, F, Izzo, F, Maffei, F, Palmieri, F, Pata, F, Porcelli, F, Selvaggi, F, Velluti, F, Mulita, F, Bello, F, Caiquo, F, Dossou, F, Eshun, F, Opoku Twene, F, Tierenye, F, Quayson, F, Romo Rosales, F, Ibanez Ortiz, F, Leon Frutos, F, Redondo Calvo, F, Silva Rivera, F, Barbosa Camacho, F, Bujalance Cabrera, F, Ruescas, F, Irakiza, F, Corvatta, F, Pascual, F, Roviello, F, Roodt, F, Gyamfi, F, Olaniru, F, Owusu, F, Bader, F, Anzinger, F, Agbodo, F, Ris, F, Agbemafoh, F, Afonso, F, Nazareth, F, Berrevoet, F, Hounde, F, Demiral, F, Hassooni, F, Kafa, G, Cardenas Rivera, G, Ntwari, G, Szydlo Shein, G, Ambriz Gonzalez, G, Nita, G, Bellio, G, Moitzi, G, Urdang, G, Marom, G, Gallo, G, Luglio, G, Poillucci, G, Singh, G, Saletta, G, Abouelnagah, G, Yarovenko, G, Kazobinka, G, Ahmed, G, Rahman, G, Smith, G, Pillai, G, Saxena, G, Gbessi, G, Nkunguzi, G, Jalal, G, Chillarge, G, Mevognon, G, Getachew, G, George, G, De La Pena Gonzalez, G, Martinez Izquierdo, G, Grande, G, Birikorang, G, Weber, G, Singer, G, Ansong, G, Bashour, G, Brown, G, Hneino, G, Kavalieratos, G, Kenchadze, G, Nagy, G, Pappas Gogos, G, Skroubis, G, Waiyaki, G, Cox, G, Zeringa, G, De Wee, G, Hart, G, Bekakos, G, Fragulidis, G, Kapogiannatos, G, Karakaidos, G, Kokkinos, G, Kostoulas, G, Koukoulis, G, Peros, G, Rados, G, Tsoulfas, G, Verras, G, Berger, G, Adoro, G, Chamoso Mialdea, G, Palmieri, G, Procaccini, G, Steenkamp, G, Viscido, G, Dajti, G, Alemayehu, G, Seyfu, G, Birqeeq, G, Alsheikh, G, Alrayyes, G, El Hunjul, G, Zaza, G, Matroud, G, Alhadwah, G, Maltinti, G, Awais, G, Shamsi, G, Calini, G, Carganico, G, Zanus, G, Canu, G, Mendiola, G, Ibero Casadiego, G, Cocorullo, G, Baronio, G, Pellino, G, Zanni, G, Poto, G, Gravante, G, Aduroja, G, Almogy, G, Bond-Smith, G, Natchagande, G, Bechara, G, Brachini, G, Riccioli, G, Ercolani, G, Farris, G, Giraudo, G, Mammolo, G, Pavone, G, Sgarzini, G, Aprea, G, Fonsi, G, Boroni, G, De Angeli, G, De Palma, G, Emiliani, G, Grava, G, Guercio, G, De Carlo, G, Del Corpo, G, Duranti, G, Galatioto, G, Grassi, G, Graziano, G, Marini, G, Munzi, G, Tarantino, G, Borda-Luque, G, Pellicano', G, Canonico, G, Carollo, G, Ietto, G, Palomba, G, Pascarella, G, Salamone, G, Sica, G, Sorrentino, G, Orlando, G, Pignata, G, Pisarevi, G, Akcakoca, G, Owusu, G, Yohanna Abrak, G, Kurtoglu, G, Kurtoglugk, G, Alici, G, Delgado Hernandez, G, Augustin, G, Bhat, G, Sundaram Venkatesan, G, Chang, G, Eke, G, Lee, G, Massarra, G, Travaglini, G, Scialandrone, G, Stavrou, G, Di Franco, G, Charalambous, G, Christodoulidis, G, Kouraklis, G, Goodwin, G, Devidze, G, Fialho, G, Santos, G, Cabezudo, G, Garcia-Santos, G, Pou, G, Romero Reyna, G, Yanowsky-Reyes, G, Ozyuksel, G, Karadeniz Cakmak, G, Kucuk, G, Bulbuloglu, G, Sarp, G, Kaur, G, Nibogora, G, Hamdan, G, Ogundipe, H, Yunes, H, Ayesh, H, Al Atassi, H, Jalilehvand, H, Masalma, H, Jafarkhan, H, Shahid, H, Younus, H, Al-Derume, H, Shames, H, Mimouni, H, Aldare, H, Odah Bashi, H, Abusnina, H, Altounsi, H, Qayum, H, Baysal, H, Bolukbasi, H, Yigitbas, H, Alkhatib, H, Afzal, H, Mftah, H, Oyinlola, H, Tumer, H, Dolo, H, Braham, H, Ozsahin, H, Abu-Arish, H, Al-Aamri, H, Fadlalmola, H, Abu Obead, H, Al-Fahel, H, Al-Zoubi, H, Asaad, H, Ejaz, H, Jaber, H, Bhatti, H, Mohammadi Sardoo, H, Farhat, H, Idheiraj, H, Zwaraa, H, Al Sohabi, H, Basharat, H, Said, H, Al-Abdallat, H, Foad, H, Daaboul, H, Al Qadhi, H, Elhallaq, H, Alhusaini, H, Lidbetter, H, Reilly, H, Moya-Ambriz, H, Lederhuber, H, Fehrer, H, Xiao, H, Iswariah, H, Kaur, H, Cheema, H, Foda, H, Chauhan, H, Sagar, H, Unwin, H, Panga, H, Gupta, H, Prabhakar, H, Anand, H, Pahwa, H, Abbadi, H, Amoudi, H, Zaini, H, Skiljo, H, Miyasika, H, Altabbaa, H, Haj Freej, H, Abdelazim, H, Habiba, H, Kamal, H, Sabir, H, Zaigham, H, Pehlivan, H, Telci, H, Abuobaida, H, Tetley, H, Taher, H, Aguado Lopez, H, Askarpour, H, Sherif Farouk Ahmed Hassan, H, Devesa, H, Arbogast, H, Nunez Del Barrio, H, Abiyere, H, Delacave, H, Rice, H, Pleass, H, Bradly, H, Islam, H, Lule, H, Abozied, H, Le Roux, H, Hamdar, H, Yaghmour, H, Bileid Bakeer, H, Al Miskry, H, Ulman, H, Abdoun, H, Essalim, H, Yonekura, H, Kato, H, Amin-Tai, H, Kynaston, H, Perez Baca, H, Irfan Khan, H, Amir, H, Elghadban, H, Elfeki, H, Wain, H, Adjei, H, Dabrowski, H, Novak, H, Alzuhd, H, Capote, H, Gomez-Fernandez, H, Stark, H, Willy-Chidire, H, Aouagbe Behanzin, H, Oneizah, H, Dalati, H, Ebied, H, Mahajna, H, Ahmad, H, Altawati, H, Adi, H, Albalawi, H, Alfakeer, H, Embarek, H, Ibrahim, H, Malkawi, H, Ekwuazi, H, Psilopatis, I, Wasiu, I, Kereet, I, Suleiman, I, Fortune, I, Aburumman, I, Adel, I, Adham, I, Ali, I, Arnaout, I, Cakir, I, Fagiri, I, Hajmohammed, I, Ozata, I, Kandil, I, Ahmed, I, Tagreda, I, Garzali, I, Nadi, I, Ogundele, I, Pius Ogolekwu, I, Shariff, I, Jakaityte, I, Abdullah, I, Babajimi-Joseph, I, Guirguis, I, Orji, I, Okoro, I, Obianyo, I, Njere, I, Ugwueke, I, Nzenwa, I, Zerrouq, I, Clementi, I, Neri, I, Yavuz, I, Hoxhaj, I, Fakhradiyev, I, R Fakhradiyev, I, Gomatos, I, Fidoshev, I, Gouazar, I, Alnimer, I, Boudis, I, Boumakhlouf, I, Abdalla, I, Herrero, I, Osman, I, Nasser, I, Singh, I, P S, I, Borges Da Costa, I, Colaco, I, Lourenco, I, Mogarrio, I, Konigsrainer, I, Hamdun, I, Tanase, I, Bokos, I, Contis, I, Demiris, I, Gerogiannis, I, Gogoulis, I, Karatsolis, I, Katsaros, I, Kozadinos, I, Margaris, I, Maroulis, I, Papaconstantinou, I, Siannis, I, Sougkas, I, Spyridakis, I, Tierris, I, Tsakiridis, I, Imihteev, I, Negoi, I, Chatzis, I, Shahbaz, I, Didier, I, Pipia, I, Parwaiz, I, Duran Sanchez, I, Norman, I, Bakaweri, I, Santos, I, Mylona, I, De Haro Jorge, I, Cervera, I, Dajti, I, Datji, I, Matache, I, Russo, I, Aremu, I, Amankwaa, I, Caitens, I, Esparza Estrada, I, Mubezi, I, Gascon Ferrer, I, Serrano, I, Dong, I, Mondi, I, Serfontein, I, Rakshit, I, Kyei, I, Murshed, I, Cabrera, I, Abo Elhagag, I, Alsoubie, I, Lawani, I, Bilgin, I, Cholah, I, Hamzaoglu, I, Maharem, I, Shehadeh, I, Hagbevor, I, Bahikoro, I, Laopeamthong, I, Mikulic, I, Bacic, I, Rakvin, I, Separovic, I, Vidic, I, Conversano, I, Mrazkova, I, Yotsov, I, Ilieva, I, Coza, I, Aljada, I, Hussein, I, Tesfahun, I, Sadiq, I, Martinez Martin Del Campo, J, Mackenzie, J, Maida, J, Kaippally, J, Montero Garcia, J, Andreuccetti, J, Martellucci, J, Secchi, J, Van Niekerk, J, Saunders, J, Duffield, J, Tavares-Ortega, J, Orozco-Perez, J, Mihanovic, J, Wolesky, J, Bryan, J, Bundred, J, Cui, J, Glasbey, J, Casella Mariolo, J, Suliman, J, Mohammad Mohammad, J, Bolanowski, J, Goedeke, J, Grosek, J, Moravik, J, Ringers, J, Roman, J, Chew, J, Maritz, J, Martin, J, Velkoski, J, Wong, J, Garcia-Quijada, J, Tk, J, Siby, J, Mcnab-Hand, J, Gusa, J, 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A., Jarimba A., Johnson A., Nunez Venzor A., Gonzalez Ojeda A., Romero De Diego A., Karamarkovic A., Butyrskii A., Edmundson A., Sidorova A., Thomas A., Tomazic A., Giuliani A., Iodice A., Marano A., Marello A., Ongaro A., Saba A., Anastasi A., Borello A., Broglia A., Carta A., Finocchio A., Francia A., Iacomino A., Izzo A., Ottaiano A., Spaziani A., Strumia A., Biancafarina A., D'Ignazio A., Davolio A., Morello A., Licciardello A., Mazzoni A., Wilkins A., Arekhandia A., Barlas A., Chamzin A., Demetriou A., Giakoustidis A., Kozadinos A., Kyriakidis A., Sarakatsanos A., Rojas A., Saridaki A., Litchinko A., Arnaud A. P., Binder A. -D., Yakubu A., Kavalakat A., Shamsutdinova A., Alberico A., Amendola A., Sanchez-Teran A. I., Lapergola A., Baiden Amissah A., Konigsrainer A., Twumasi A., Alhebshi A., Abbas A., Abdul Rahman A., Abidali A., Abu Tair A., Ahmad A., Al Mukhtar A., Sharq A. A., Alloush A., Amaigl A., Kheirkhah Vakilabad A. A., Bassma A., Hacioglu A. 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C., Damigella A., Manetti A., Mingoli A., Natili A., Police A., Razzore A., Scacchi A., Vazquez Fernandez A., Luzzi A. -P., Brosin A., Efstathiou A., Kirschniak A., Panagakis A., Pilavas A., Scheiwiller A., Skarpas A., Chitul A., Trif A., Ferreira A., Silva A., Subocius A., Cembellin A., Garcia Marin A., Ang A., Gray A., Li A., Skreka A. -M., Abdul Rahim A. A., Bhangu A., Moncy A., Mwanjoka A., Fernandez Camunas A., De Jesus Gil A., Molero A., Sultana A., Suarez Alvarez A. A., Nava Franco A. M., Autiak Ayii Chol A., Serao A., Nikolaou A. I., Hassanin A., Evans A., Vu A., Lala A. K., Luther A., Sundaram A., Cerovac A., Abgeko A. E., Agbeko A. E., Sharma A., Jain A., Attili A., Alecci A., D'Amore A., Domenech Plana A., Gut A. E., John A., Lareida A., Pesce A. L., Paspala A., Sharp A., Victor A., Comandatore A., Olsen A., Yiallourou A., Loizou A., Asare Twumasi A., Davor A., Tabiim A. J., Lin A., Szpytko A., Walfor A., Oosterkamp A., Kachi A., Khoneisser A., Bediako Bowan A., Sumbaev A., Deserra A., Punzengruber A., Thanasa A., Azzinnaro A., Castaldi A., Curado Soriano A., Garcia Dominguez A., Lai A., Martinez German A., Masciandaro A., Miele A., Pesce A., Ramirez Beas A., Ramos Bonilla A., Ramos-De la Medina A., Zerbinati A., Athanasiou A., Panagidis A., Vezakis A., Boynes A., Mishra A., Singh A., Appukuttan A., Alhamadi A., Gusibat A., Seidu A. S., Fuertes Munoz A. N., Shanker A., Balta A., Panagopoulos A., Roslani A., Tahir A., Hernandez A., Roumieh A., Pinto A., Khanduri A., Isik A., Dhinakar A. S. P., Ioannidis A., Tsiaka A., Balconi A., Petrungaro A., Narin A. 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A., Smith G., Pillai G., Saxena G., Gbessi G., Nkunguzi G., Jalal G., Chillarge G., Mevognon G., Getachew G., George G., De La Pena Gonzalez G., Martinez Izquierdo G., Grande G., Birikorang G., Weber G. F., Singer G., Ansong G., Bashour G., Brown G. D., Hneino G., Kavalieratos G., Kenchadze G., Nagy G., Pappas Gogos G., Skroubis G., Waiyaki G., Cox G., Zeringa G., De Wee G., Hart G., Bekakos G., Fragulidis G., Kapogiannatos G., Karakaidos G., Kokkinos G., Kostoulas G., Koukoulis G., Peros G., Rados G., Tsoulfas G., Verras G. -I., Berger G., Adoro G. A., Chamoso Mialdea G., Palmieri G., Procaccini G., Steenkamp G., Viscido G. R., Dajti G., Alemayehu G., Seyfu G., Birqeeq G., Alsheikh G., Alrayyes G., El Hunjul G. N., Zaza G., Matroud G., Alhadwah G., Maltinti G., Awais G., Shamsi G., Calini G., Carganico G., Zanus G., Canu G. L., Mendiola G., Ibero Casadiego G. P., Cocorullo G., Baronio G., Pellino G., Zanni G., Poto G. 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R., Devidze G., Fialho G., Santos G., Cabezudo G., Garcia-Santos G., Pou G., Romero Reyna G., Yanowsky-Reyes G., Ozyuksel G., Karadeniz Cakmak G., Kucuk G. O., Bulbuloglu G. C., Sarp G., Kaur G., Nibogora G. D., Hamdan G., Ogundipe H., Yunes H., Ayesh H., Al Atassi H., Jalilehvand H., Masalma H., Jafarkhan H., Shahid H. H., Younus H., Al-Derume H., Shames H., Mimouni H. A., Aldare H., Odah Bashi H. O., Abusnina H., Altounsi H., Qayum H., Baysal H., Bolukbasi H., Yigitbas H., Alkhatib H., Afzal H., Mftah H., Oyinlola H., Tumer H., Dolo H., Braham H., Ozsahin H., Abu-Arish H., Al-Aamri H., Fadlalmola H. A., Abu Obead H., Al-Fahel H., Al-Zoubi H., Asaad H., Ejaz H., Jaber H., Bhatti H. W., Mohammadi Sardoo H., Farhat H., Idheiraj H., Zwaraa H., Al Sohabi H., Basharat H., Said H., Al-Abdallat H., Foad H., Daaboul H., Al Qadhi H., Elhallaq H., Alhusaini H., Lidbetter H., Reilly H., Moya-Ambriz H. B., Lederhuber H., Fehrer H. -J., Xiao H., Iswariah H., Kaur H., Cheema H. 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A., Dalati H., Ebied H., Mahajna H., Ahmad H., Altawati H., Adi H., Albalawi H., Alfakeer H., Embarek H., Ibrahim H., Malkawi H., Ekwuazi H., Psilopatis I., Wasiu I., Kereet I. M., Suleiman I., Fortune I., Aburumman I., Adel I., Adham I., Ali I., Arnaout I., Cakir I., Suleiman I. E., Fagiri I., Hajmohammed I., Ozata I. H., Kandil I., Ahmed I. M. G., Tagreda I., Garzali I. U., Nadi I., Ogundele I., Pius Ogolekwu I., Shariff I., Jakaityte I., Abdullah I., Babajimi-Joseph I., Guirguis I., Orji I., Okoro I., Ahmed I., Obianyo I., Njere I., Ugwueke I., Nzenwa I. C., Zerrouq I., Clementi I., Neri I., Yavuz I. E., Hoxhaj I., Fakhradiyev I., R Fakhradiyev I., Gomatos I., Fidoshev I., Gouazar I., Alnimer I., Boudis I. E., Boumakhlouf I. E., Abdalla I., Herrero I., Osman I., Nasser I., Singh I., P S I., Borges Da Costa I., Colaco I., Lourenco I. M., Mogarrio I., Konigsrainer I., Hamdun I. H. S., Tanase I., Bokos I., Contis I., Demiris I., Gerogiannis I., Gogoulis I., Karatsolis I., Katsaros I., Kozadinos I., Margaris I., Maroulis I., Papaconstantinou I., Siannis I., Sougkas I., Spyridakis I., Tierris I., Tsakiridis I., Imihteev I., Negoi I., Chatzis I., Shahbaz I., Didier I., Pipia I., Parwaiz I., Duran Sanchez I. I., Norman I., Bakaweri I. N., Santos I., Mylona I. C., De Haro Jorge I., Cervera I., Dajti I., Datji I., Matache I. M., Russo I. S., Aremu I. I., Amankwaa I., Caitens I., Esparza Estrada I., Mubezi I., Gascon Ferrer I., Serrano I., Dong I., Mondi I., Serfontein I., Rakshit I., Kyei I., Murshed I., Cabrera I., Abo Elhagag I., Alsoubie I., Lawani I., Bilgin I. A., Cholah I., Hamzaoglu I., Maharem I., Shehadeh I., Hagbevor I., Bahikoro I. W., Laopeamthong I., Mikulic I., Bacic I., Rakvin I., Separovic I., Vidic I., Conversano I., Mrazkova I., Yotsov I., Ilieva I., Coza I., Aljada I., Hussein I., Tesfahun I., Sadiq I., Martinez Martin Del Campo J. 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A., Omoike O., cancar O., Ekwunife O. H., Emuze O., Eljizoly O. A., Al Hamdani O., Emadeldeen O., Morgan O., Olajumoke O., Popoola O., Ajiboye O., Olasehinde O., Jolayemi O., Babatunde O., Balogun O., Olajide O., Lisin O., Bellou O., Juric O., Ladlow O., Whitehurst O., Camilleri O., Montano Angeles O., Pryer O., Ray O., Gabom O., Ndizeye O., Ojewuyi O., Oluyemi O., Elebute O., Ogunsua O., Fasiku O. K., Fasoro O., Fatudimu O., Osunlusi O., Owolanke O., Oso O., Alaba O., Ojo O., Oluseye O., Oyinloye O., Al Alyani O., Okrah O., Agha O., Al-Fahel O., Almomani O., Alruwaili O., Ibarra O., Ibrahim O., Khalil O., Kouli O., Lima Azurdia O., Mansour O., Mohamed Mokbel O., Omar O., Bedak O., Ozkan O. F., Yalkin O., Mohamed O., Ayandipo O., Faboya O., Williams O. M., Irowa O., Attawodi O., Salako O., Ioannidis O., Agcaoglu O., Martin Sole O., Webster O., Abouhiekal O., Al Shaqran O., Bahsas-Zaky O., Nubi O. G., Hany O., Matar O., Mahafdah O. R., Sarhan O., Osagie O., Soublett Rivas O. 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B., Sellahewa S., Neogi S., Burger S., Polat S., Alkadi S., Asiri S., Otho S., Mewa Kinoo S., Ebrahim S., Tontus S., Midya S., Thuraisamy Sarma S. I., Payyanur Thotan S., Kumar Venkatappa S., Techapongsatorn S., Kaur S., Jp S., Tan S., Djote S. M., Surendran S., Chilaka S., Lee S., Henriques S., Giridaran S., Achugatla S., Kumar S., Brincat S., Deshpande S., Batista S., Akharaekpanya T., Moges T. G., Turkmen T. B., Alhaj Hasan T., Alshawabkeh T., Majed T., Lawal T. A., Ibiyeye T. T., Rashid T., Kosir Bozic T., Mohammed T., Khewater T., Abelman T., Al Barhi T., Mogne T., Salazar-Lorenzana T. A., Akter T., Gomez Sanz T., Motiwala T., Valizadeh Elizeh T., Almahdi T., Albushary T. A., Abdulrahman T., Finlay T., Chouari T., Awad T., Sabra T., M. Abubasheer T., Alhusban T., Yilmaz T. E., Aloqaili T., Aldirawi T., Karahasanoglu T., Gulsen T., Jemal T., Nadeem T., Singh T. P., Alinger T., Longkumer T., Lo T., Gimenez Maurel T., Uprak T. 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- Abstract
Background: Timely and safe elective health care facilitates return to normal activities for patients and prevents emergency admissions. Surgery is a cornerstone of elective care and relies on complex pathways. This study aimed to take a whole-system approach to evaluating access to and quality of elective health care globally, using inguinal hernia as a tracer condition. Methods: This was a prospective, international, cohort study conducted between Jan 30 and May 21, 2023, in which any hospital performing inguinal hernia repairs was eligible to take part. Consecutive patients of any age undergoing primary inguinal hernia repair were included. A measurement set mapped to the attributes of WHO's Health System Building Blocks was defined to evaluate access (emergency surgery rates, bowel resection rates, and waiting times) and quality (mesh use, day-case rates, and postoperative complications). These were compared across World Bank income groups (high-income, upper-middle-income, lower-middle-income, and low-income countries), adjusted for hospital and country. Factors associated with postoperative complications were explored with a three-level multilevel logistic regression model. Findings: 18 058 patients from 640 hospitals in 83 countries were included, of whom 1287 (7·1%) underwent emergency surgery. Emergency surgery rates increased from high-income to low-income countries (6·8%, 9·7%, 11·4%, 14·2%), accompanied by an increase in bowel resection rates (1·2%, 1·4%, 2·3%, 4·2%). Overall waiting times for elective surgery were similar around the world (median 8·0 months from symptoms to surgery), largely because of delays between symptom onset and diagnosis rather than waiting for treatment. In 14 768 elective operations in adults, mesh use decreased from high-income to low-income countries (97·6%, 94·3%, 80·6%, 61·0%). In patients eligible for day-case surgery (n=12 658), day-case rates were low and variable (50·0%, 38·0%, 42·1%, 44·5%). Complications occurred in 2
- Published
- 2024
3. Assessment of fetal head station with transperineal ultrasound: automatic approach versus expert operator evaluation
- Author
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Giovanna DI Trani, MARIA, primary, Morello, R., additional, Vimercati, A., additional, Conversano, F., additional, Pignatelli, D., additional, Pisani, P., additional, Di Paola, M., additional, and Casciaro, S., additional
- Published
- 2024
- Full Text
- View/download PDF
4. Von Hippel–Lindau disease: a single gene, several hereditary tumors
- Author
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Crespigio, J., Berbel, L. C. L., Dias, M. A., Berbel, R. F., Pereira, S. S., Pignatelli, D., and Mazzuco, T. L.
- Published
- 2017
- Full Text
- View/download PDF
5. Post-Operative Patients' Satisfaction and Quality of Life Assessment in Adult Patients with Obstructive Sleep Apnea Syndrome (OSAS)
- Author
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Rossi, D.S., Goker, F., Cullati, F., Baj, A., Pignatelli, D., Gianni, A.B., and Del Fabbro, M.
- Subjects
Adult ,Sleep Apnea, Obstructive ,Sleep Apnea ,Obstructive ,Orthognathic Surgical Procedures ,orthognathic surgery ,bi-maxillary surgery ,Settore MED/50 - Scienze Tecniche Mediche Applicate ,OSAS ,Settore MED/29 - Chirurgia Maxillofacciale ,Sleep Apnea Syndromes ,maxillomandibular advancement surgery ,Humans ,Patient Satisfaction ,Quality of Life ,Settore MED/28 - Malattie Odontostomatologiche - Abstract
The treatment for severe OSAS includes maxillomandibular advancement surgical option in selected cases. The aim of this study was to evaluate the post-operative impact of bimaxillary surgery on satisfaction and consequently the quality of life of these patients.This study included 18 patients with severe OSAS who received maxillomandibular advancement surgery. Patients were divided into Group A (operated by CAD/CAM) and Group B (conventional surgery). The impact of bimaxillary surgery on satisfaction and quality of life of these patients was evaluated by utilizing post-operative life quality and Rustemeyer's patient-satisfaction-based survey.A total of 18 adult OSAS patients (Group A: 11 patients, Group B: 7 patients) with a mean age of 44.39 years (SD ± 9.43) were included. Mean follow-up period was 32.64 months (SD ± 21.91). No intra-operative complications were seen in any patients. Post-operative complication was seen in one patient and the mandible did not integrate. According to the results, overall post-operative satisfaction score was 79.72% (SD ± 9.96). There was no significant difference among those in Group A and Group B.Maxillomandibular advancement surgery seems to be beneficial in terms of patients' satisfaction in severe adult OSAS patients and can be considered as a valuable option in selected cases.
- Published
- 2022
6. A novel artificial intelligence approach for the automatic differentiation of fetal occiput anterior and non‐occiput anterior positions during labor
- Author
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Ghi, T, Conversano, F, Ramirez Zegarra, R, Pisani, P, Dall′Asta, A, Lanzone, A, Lau, W, Vimercati, A, Iliescu, Dg, Mappa, I, Rizzo, G, Casciaro, S, Morello, R, Schera, Gbl, Franchini, R, Fieni, S, Di Trani, Mg, Pignatelli, D, Sirico, A, Hung, C, Dîră, L, Levy, R, Vaisbuch, E, Lees, C, Usman, S, Iurlaro, E, Tondo, M, Winkler, A, Hassan, Wa, Taylor, S, Wiafe, Ya, Eggebø, Tm, Henrich, W, Hinkson, L, and Vaso, E
- Subjects
Adult ,Automatic differentiation ,Ultrasonography, Prenatal ,Labor Presentation ,Fetus ,Artificial Intelligence ,Labor Stage, Second ,Pregnancy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Fetal head ,Prospective Studies ,Stage (cooking) ,Prospective cohort study ,Radiological and Ultrasound Technology ,business.industry ,Cephalic presentation ,Obstetrics and Gynecology ,Occiput ,General Medicine ,Gold standard (test) ,Obstetric Labor Complications ,medicine.anatomical_structure ,Reproductive Medicine ,Settore MED/40 ,Area Under Curve ,Female ,Nuclear medicine ,business ,Head ,Kappa - Abstract
OBJECTIVES The aim of this study is to develop a Machine Learning (ML) algorithm for an automatic classification of fetal occiput position at transperineal ultrasound (TPU) during the second stage of labor. METHODS Prospective cohort study including singleton term pregnancies (> 37 weeks of gestation) in the second stage of labor, with the fetus in cephalic presentation. Transabdominal ultrasound was preliminarily performed to assess the actual fetal occiput position, which was labeled as occiput anterior (OA) or non-occiput anterior (non-OA). Subsequently, for each case, one sonographic image of the fetal head was acquired on the axial plane using TPU and archived on a cloud for remote analysis. Using the transabdominal sonographic diagnosis as the gold standard, a ML algorithm based on a pattern recognition feed-forward neural network was trained on the transperineal images to discriminate between OA and non-OA cases. In the training phase the model tuned its parameters in order to approximate correctly the training data - i.e., the training dataset - in order to correctly assess the fetal head position, by exploiting geometric, morphological and intensity-based features of the images. In the testing phase, the diagnostic performance of the algorithm was evaluated on unlabeled data, which represented the testing dataset. On this group the ability of the ML algorithm to differentiate the OA from the non-OA fetal positions was assessed in terms of diagnostic accuracy. The F1 -score and Precision-Recall Area Under the Curve (PR-AUC) were also calculated to assess the algorithm's performance. The Cohen's kappa (k) was finally added to evaluate the agreement between the algorithm and the gold standard. RESULTS Over a period of 24 months, 1219 women in the second stage of labor were enrolled. They were classified as OA (n=801 or 65.7%) or non-OA (n=418 or 34.3%) on the basis of transabdominal ultrasound. From both the sub-groups (OA and non-OA), 70% of the patients were randomly assigned to the training dataset (824 patients) while the remaining 30% (395 patients) were used as testing dataset. On the latter group the ML based algorithm yielded a correct classification of the fetal occiput position in 90.6% of cases (357 out of 395), including 224 out of 246 OA (91.0%) and of 133 out of 149 non-OA images (89.3%). Moreover, for the evaluation the algorithm's performance we found a F1 -score=88.7% and PR-AUC=85.4%. The algorithm showed a balanced performance in the recognition of both anterior and non-anterior occiput positions. Eventually, the robustness of the proposed algorithm was confirmed by a high agreement with the gold standard method (k = 0.81; p
- Published
- 2022
7. Stimulating living cells with air DBD plasma
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Favia, P., Pignatelli, D., Dilecce, G., Pistillo, B. R., Nardulli, M., and Gristina, R.
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- 2012
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8. New technique for automatic sonographic measurement of change in head–perineum distance and angle of progression during active phase of second stage of labor
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Angeli, L., primary, Conversano, F., additional, Dall'Asta, A., additional, Volpe, N., additional, Simone, M., additional, Di Pasquo, E., additional, Pignatelli, D., additional, Schera, G. B. L., additional, Di Paola, M., additional, Ricciardi, P., additional, Ferretti, A., additional, Frusca, T., additional, Casciaro, S., additional, and Ghi, T., additional
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- 2020
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9. Analysis and comparison of quality of life and patients’ satisfaction between dental-skeletal dysmorphisms and Obstructive Sleep Apnea (OSA) patients following orthognathic surgery.
- Author
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ROSSI, D. S., GOKER, F., CULLATI, F., BAJ, A., PIGNATELLI, D., BELTRAMINI, G., RUSSILLO, A., GIANNÌ, A. B., LUCCHINA, A. G., MORTELLARO, C., and DEL FABBRO, M.
- Abstract
OBJECTIVE: The aim of this study was to evaluate the impact of orthognathic surgery on the patients’ satisfaction and quality of life (QoL) in patients with dental skeletal dysmorphisms and Obstructive Sleep Apnea (OSA). SUBJECTS AND METHODS: Patients were grouped into two cohorts, patients with OSA (G1) and patients with dento-skeletal dysmorphisms (G2). SF-36 questionnaire was obtained from all subjects before interventions. A standardized follow-up protocol, including a second SF-36 questionnaire was planned as at least 6 months after surgery. The impact of surgery on satisfaction was evaluated by post-operative patient satisfaction-based survey. RESULTS: 61 patients were included as: 21 OSA (G1), 12 Class II (G2-a) and 28 Class III (G2-b) patients. The mean post-operative follow-up was 65.47±26.36 months. In the SF-36 results, when pre and post operative surveys were compared, the quality of life increased significantly for G1 in all items except for body pain. In G2, when pre and post operative surveys were compared, the quality of life increased significantly in items related to emotional well-being, health transition, role limitations due to emotional problems, while other parameters did not significantly change. When groups were compared, there was no difference among them except for physical functioning which was improved for OSA patients. According to the Rustemeyer results, overall post-operative satisfaction score was 84.92±14.72%. There was a significant difference for patient satisfaction considering facial aesthetics in both groups. For chewing function there was no difference for patient satisfaction in G1, but there was a significant difference in G2 patients. CONCLUSIONS: Orthognathic surgery seems to be beneficial in terms of patients’ satisfaction and patients’ satisfaction for both dental skeletal dysmorphism and OSA patients. [ABSTRACT FROM AUTHOR]
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- 2022
10. Metabolic Perspectives for Non-classical Congenital Adrenal Hyperplasia With Relation to the Classical Form of the Disease
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Macut, D. Zdravković, V. Bjekić-Macut, J. Mastorakos, G. Pignatelli, D.
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congenital, hereditary, and neonatal diseases and abnormalities ,endocrine system diseases ,nutritional and metabolic diseases ,urologic and male genital diseases ,female genital diseases and pregnancy complications - Abstract
Non-classical congenital adrenal hyperplasia (NC-CAH) represents mild form of CAH with the prevalence of 0. 6 to 9% in women with androgen excess. Clinical and hormonal findings in females with NC-CAH are overlapping with other hyperandrogenic entities such as polycystic ovary syndrome hence causing difficulties in diagnostic approach. Metabolic consequences in subjects with NC-CAH are relatively unknown. We are lacking longitudinal follow of these patients regarding natural course of the disease or the therapeutic effects of the different drug regiments. Patients with NC-CAH similarly to those with classical form are characterized with deteriorated cardiovascular risk factors that are probably translated into cardiometabolic diseases and events. An increased preponderance of obesity and insulin resistance in patients with NC-CAH begin at young age could result in increased rates of metabolic sequelae and cardiovascular disease later during adulthood in both sexes. On the other hand, growth disorder was not proven in patients with NC-CAH in comparison to CAH patients of both gender characterized with reduced final adult height. Similarly, decreased bone mineral density and osteoporosis are not constant findings in patients with NC-CAH and could depend on the sex, and type or dose of corticosteroids applied. It could be concluded that NC-CAH represent a particular form of CAH that is characterized with specificities in clinical presentation, diagnosis, therapeutic approach and metabolic outcomes. © Copyright © 2019 Macut, Zdravković, Bjekić-Macut, Mastorakos and Pignatelli.
- Published
- 2019
11. Reproductive Outcome of Women with 21-Hydroxylase-Deficient Nonclassic Adrenal Hyperplasia
- Author
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Moran, C, Azziz, R, Weintrob, N, Witchel, S F., Rohmer, V, Dewailly, D, Marcondes, J A. M., Pugeat, M, Speiser, P W., Pignatelli, D, Mendonca, B B., Bachega, T A. S., Escobar-Morreale, H F., Carmina, E, Fruzzetti, F, and Kelestimur, F
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- 2006
12. Developing and evaluating rare disease educational materials co-created by expert clinicians and patients: the paradigm of congenital hypogonadotropic hypogonadism
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COST Action BM1105, Badiu, C, Bonomi, M, Borshchevsky, I, Cools, M, Craen, M, Ghervan, C, Hauschild, M, Hershkovitz, E, Hrabovszky, E, Juul, A, Kim, S, Kumanov, P, Lecumberri, B, Lemos, MC, Neocleous, V, Niedziela, M, Pekic, S, Persani, L, Phan-Hug, F, Pignatelli, D, Pitteloud, N, Popovic, V, Quinton, R, Skordis, N, Smith, N, Stefanija, MA, Xu, C, Young, J, and Dwyer, AA
- Abstract
Background\ud \ud Patients with rare diseases face health disparities and are often challenged to find accurate information about their condition. We aimed to use the best available evidence and community partnerships to produce patient education materials for congenital hypogonadotropic hypogonadism (CHH) and the olfacto-genital (Kallmann) syndrome (i.e., CHH and defective sense of smell), and to evaluate end-user acceptability. Expert clinicians, researchers and patients co-created the materials in a multi-step process. Six validated algorithms were used to assess reading level of the final product. Comprehensibility and actionability were measured using the Patient Education Materials Assessment Tool via web-based data collection. Descriptive statistics were employed to summarize data and thematic analysis for analyzing open-ended responses. Subsequently, translation and cultural adaption were conducted by clinicians and patients who are native speakers.\ud Results\ud \ud Co-created patient education materials reached the target 6th grade reading level according to 2/6 (33%) algorithms (range: grade 5.9–9.7). The online survey received 164 hits in 2 months and 63/159 (40%) of eligible patients completed the evaluation. Patients ranged in age from 18 to 66 years (median 36, mean 39 ± 11) and 52/63 (83%), had adequate health literacy. Patients scored understandability at 94.2% and actionability at 90.5%. The patient education materials were culturally adapted and translated into 20 languages (available in Additional file 1).\ud Conclusions\ud \ud Partnering with patients enabled us to create patient education materials that met patient- identified needs as evidenced by high end-user acceptability, understandability and actionability. The web-based evaluation was effective for reaching dispersed rare disease patients. Combining dissemination via traditional healthcare professional platforms as well as patient-centric sites can facilitate broad uptake of culturally adapted translations. This process may serve as a roadmap for creating patient education materials for other rare diseases.
- Published
- 2017
13. Gastroenterite Aguda por Salmonella Não Tifoide em Crianças: Revisão de 10 Anos
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Pignatelli, D, Leal, E, Lito, D, Dâmaso, C, Rodrigues, M, and Cunha, F
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Infecções por Salmonella ,Salmonella ,Gastroenterite ,Bacteriemia ,HDE PED ,Criança ,Resistência Bacteriana aos Antibióticos ,Resistência antibiótica - Abstract
Introdução: A Salmonella não tifoide é o agente mais frequente das toxinfeções alimentares nos países desenvolvidos. Em Portugal, são notificados em média 450 casos por ano, 80% dos quais em crianças. Métodos: Revisão casuística dos casos confirmados por coprocultura, internados num hospital do grupo I, na região de Lisboa e Vale do Tejo, entre 1999 e 2008. Análise estatística no programa SPSS® v16.0, com aplicação do teste de Spearman e significância estatística para p< 0,05. Resultados: Identificaram-se 213 internamentos. A mediana anual foi de 21 internamentos, 39% ocorrendo no verão. A mediana das idades foi de 4,2 anos, com doze casos em lactentes até aos três meses. Houve um predomínio no sexo masculino (57%). A mediana do total de leucócitos foi de 9300/mL e da proteína C reativa de 8,8 mg/dL, não se relacionando com a ocorrência de bacteriemia. A duração média do internamento foi de 5,2 dias. As principais complicações foram desidratação (117/213), bacteriemia (8/213), convulsão febril (6/213), síndrome de Mallory-Weiss (5/213) e apendicite aguda (3/213). Os serotipos mais isolados foram: S. Enteritidis (76%), S. Typhimurium (19%), outros (S. O4,5:i-, S. Derby, S. Hayfa, S. Menden, S. Rissen) (5%). Encontraram-se 27% de resistências à ampicilina e 15% ao trimetoprim-sulfametoxazol, sem resistências ao ceftriaxone. Conclusões: Nos 10 anos estudados, o número de casos manteve-se elevado, com morbilidade relevante e resistências significativas aos antibióticos de primeira linha.
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- 2014
14. Von Hippel-Lindau disease: a single gene, several hereditary tumors.
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Crespigio, J., Berbel, L., Dias, M., Berbel, R., Pereira, S., Pignatelli, D., and Mazzuco, T.
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- 2018
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15. Comorbilidades microvasculares da Diabetes Mellitus: Implicações na percepção da qualidade de vida relacionada com a saúde
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Sepúlveda, E., Poínhos, Rui, Constante, M., Pais-Ribeiro, J., Freitas, P., Pignatelli, D., Carvalho, D., and Faculdade de Ciências da Nutrição e Alimentação
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Health sciences, Medical and Health sciences ,Ciências médicas e da saúde ,Medical and Health sciences ,Ciências da Saúde, Ciências médicas e da saúde - Abstract
[resumo] [abstract]
- Published
- 2012
16. CO032. ASSOCIAÇÃO ENTRE A AUTOVIGILÂNCIA E A ADESÃO TERAPÊUTICA EM DIABÉTICOS TIPO 2 E A PERCEPÇÃO DA QUALIDADE DE VIDA
- Author
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Sepúlveda, E., primary, Poínhos, R., additional, Fernandes, G., additional, Freitas, P., additional, Pignatelli, D., additional, and Carvalho, D., additional
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- 2012
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17. Remote and Direct Plasma Processing of Cells: How to Induce a Desired Behavior
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Gristina, Roberto, primary, Nardulli, M., additional, Sardella, E., additional, Intranuovo, F., additional, Salama, R.A., additional, Pignatelli, D., additional, Pistillo, B.R., additional, Dilecce, G., additional, D'Agostino, R., additional, and Favia, Pietro, additional
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- 2012
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18. Risco de diabetes mellitus em familiares de diabéticos tratados com insulina
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Barros, H, Pignatelli, D, Pereira, S, Oliveira, J P, and Maia, J C
- Published
- 1994
19. Mutational Characterization of Steroid 21-Hydroxylase Gene in Portuguese patients with Congenital Adrenal Hyperplasia
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Marques, C. J., primary, Pignatelli, D., additional, Carvalho, B., additional, Barceló, J., additional, Almeida, A. C., additional, Fernandes, S., additional, Witchel, S. F., additional, Sousa, M., additional, Oliveira, M. J., additional, Freitas, P., additional, Fontoura, M., additional, Carvalho, D., additional, Barros, A., additional, and Carvalho, F., additional
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- 2009
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20. Reproductive Outcome of Women With 21-Hydroxylase-Deficient Nonclassic Adrenal Hyperplasia
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Moran, C, primary, Azziz, R, additional, Weintrob, N, additional, Witchel, S F., additional, Rohmer, V, additional, Dewailly, D, additional, Marcondes, J A. M., additional, Pugeat, M, additional, Speiser, P W., additional, Pignatelli, D, additional, Mendonca, B B., additional, Bachega, T A. S., additional, Escobar-Morreale, H F., additional, Carmina, E, additional, Fruzzetti, F, additional, and Kelestimur, F, additional
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- 2007
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21. A Comparison of Insulin Action Between Women With 21-Hydroxylase-Deficient Nonclassic Adrenal Hyperplasia (NCAH) and Polycystic Ovary Syndrome (PCOS)
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Pall, M., primary, Pignatelli, D., additional, Beires, J., additional, and Azziz, R., additional
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- 2005
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22. Change in the diagnosis of patients with idiopathic hirsutism (IH) to Polycystic Ovary Syndrome (PCOS) due to the use of the 2003 Rotterdam criteria
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Kumar, A.V., primary, Pignatelli, D., additional, Decherney, A.H., additional, and Azziz, R., additional
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- 2004
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23. ACTH Modulates ERK Phosphorylation in the Adrenal Gland in a Time‐Dependent Manner
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Ferreira, J. G., primary, Cruz, C., additional, Vinson, G. P., additional, and Pignatelli, D., additional
- Published
- 2004
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24. PROLIFERATION OF CAPSULAR STEM CELLS INDUCED BY ACTH IN THE RAT ADRENAL CORTEX
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Pignatelli, D., primary, Ferreira, J., additional, Vendeira, P., additional, Magalhães, M. C., additional, and Vinson, G. P., additional
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- 2002
- Full Text
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25. Effects of prolonged infusion of basic fibroblast growth factor and IGF-I on adrenocortical differentiation in the autotransplanted adrenal: an immunohistochemical study
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Vendeira, P, primary, Pignatelli, D, additional, Neves, D, additional, Magalhaes, MM, additional, Magalhaes, MC, additional, and Vinson, GP, additional
- Published
- 1999
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26. The development of the adrenal gland zona glomerulosa in the rat. A morphological, immunohistochemical and biochemical study
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Pignatelli, D, primary, Pinto, P, additional, Magalhães, M.M, additional, and Magalhães, M.C, additional
- Published
- 1998
- Full Text
- View/download PDF
27. Direct Effects of Stress on Adrenocortical Function
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Pignatelli, D., primary and Magalhães, M., additional
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- 1998
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28. Acute stress effects on the adrenal cortex in the rat. A biochemical and immunohistochemical study.
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Pignatelli, D., primary, Pinto, P., additional, Azevedo, M. E., additional, Magalhães, M. M., additional, and Magalhães, M. C., additional
- Published
- 1996
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29. New insights into zonal differentiation of adrenal autotransplants in the rat: an immunohistochemical study
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Vendeira, P, primary, Pignatelli, D, additional, Neves, D, additional, Magalhães, M M, additional, Magalhães, M C, additional, Ho, M M, additional, and Vinson, G P, additional
- Published
- 1996
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30. Clinical Experience with Somatrem in Growth Hormone Deficiency.
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CARVALHO, D., FIGUEIREDO, S., PIGNATELLI, D., FONSECA, M., CASTEDO, J.L., BACELAR, C., COELHO, B., PORTOCARRERO, M.C., BALDAQUE-FARIA, A., SOUSA, G., VILA-COVA, L., and HARGREAVES, M.P.
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- 1988
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31. Importance of serum frutosamine assessment in monitoring the metabolic status of diabetic patients,IMPORTANCIA DO DOSEAMENTO SERICO DA FRUTOSAMINA NA MONITORIZACAO DO EQUILIBRIO METABOLICO DO DIABETICO
- Author
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Alves, V., Carvalho, M., Davide Carvalho, Pignatelli, D., Vinha, E., M Edina, J. L., and Pessanha Moreira, J.
32. Postnatal maturation of primary afferent terminations in the substantia gelatinosa of the rat spinal cord. An electron microscopic study
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Pignatelli, D., primary, Ribeiro-da-Silva, A., additional, and Coimbra, A., additional
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- 1989
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33. Rexed's laminae and the acid phosphatase (FRAP)-band in the superficial dorsal horn of the neonatal rat spinal cord
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Coimbra, A., primary, Ribeiro-Da-Silva, A., additional, and Pignatelli, D., additional
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- 1986
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34. Subcutaneous insulin pump therapy in a diabetic patient submitted to major surgery
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Reis, J P L, primary, Pignatelli, D, additional, Madeira, D, additional, Castedo, J L, additional, and de Oliveira, M C, additional
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- 1988
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35. Etomidate and Cushing's syndrome
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COSTA, J., primary, RAMOS, D., additional, MASSAVA, S., additional, CARVALHO, D., additional, and PIGNATELLI, D., additional
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- 1986
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36. Città, fondazioni e moneta: una questione controversa
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R. Vitale, N. Busino, P. Carfora, D. Carmosino, A. Casalboni, G. Celato, M. Cesarano, S. Conti, F. Delle Donne, A. Di Muro, T. D'Urso, M. Ginatempo, L. Petracca, M.G. Pezone, G. Pignatelli, D. Proietti, G. Renda, M. Rinaldi, M. Rotili, R. Vitale, N. Busino, D. Proietti, and Vitale, R.
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città, monetazione antica, istituzioni, Magna Grecia - Published
- 2023
37. Androgens and Severe Insulin Resistance States: Basic and Clinical Aspects
- Author
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L. Zanotti, Alessandra Gambineri, Daniela Ibarra-Gasparini, Pasquali, R, Pignatelli, D, Gambineri A., Zanotti L., and Ibarra-Gasparini D.
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medicine.medical_specialty ,business.industry ,Insulin ,medicine.medical_treatment ,Hyperandrogenism ,Adipose tissue ,030209 endocrinology & metabolism ,Biochemical biomarkers ,medicine.disease ,Polycystic ovary ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Internal medicine ,Medicine ,NA ,Signal transduction ,business ,Gene screening - Abstract
Hyperandrogenism with or without polycystic ovary syndrome can be sustained by an extreme form of insulin resistance (IR), and is thus a secondary form of hyperandrogenism, which may be due to a defect in insulin signal transduction or in the adipose tissue. Severe IR due to adipose tissue dysfunction is the most frequent form, which may be the result of a deficiency in the adipose tissue, that is, the lipodystrophies, or to the unrestrained accumulation of adipose tissue. These forms are in some cases produced by a single-gene defect. The diagnosis remains predominantly clinical by examining patients in their underwear and looking out for clinical hallmarks, supported by biochemical biomarkers. Gene screening is necessary to corroborate the diagnosis of some forms. Clinicians who deal with hyperandrogenic disorders should be alerted to the forms that are secondary to severe IR, as they are not as uncommon as often imagined and frequently respond to tailored therapies.
- Published
- 2019
38. Reproductive outcome of women with 21-hydroxylase-deficient nonclassic adrenal hyperplasia
- Author
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N. Weintrob, Enrico Carmina, Didier Dewailly, Phyllis W. Speiser, Fahrettin Kelestimur, Tânia A.S.S. Bachega, Ricardo Azziz, Franca Fruzzetti, Duarte Pignatelli, José Antonio Miguel Marcondes, Vincent Rohmer, Héctor F. Escobar-Morreale, C. Moran, Selma F. Witchel, Michel Pugeat, Berenice B. Mendonca, MORAN C, AZZIZ R, WEINTROB N, WITCHEL SF, ROHMER V, DEWAILLY D, MARCONIDES JA, PUGEAT M, SPEISER PW, PIGNATELLI D, MENDONCA BB, BACHEGA TA, ESCOBAR-MORREALE HF, CARMINA E, FRUZZETTI F, and KELESTIMUR F
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Referral ,Genotype ,Offspring ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Context (language use) ,Asymptomatic ,Biochemistry ,Endocrinology ,Pregnancy ,Internal medicine ,Prevalence ,Medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Adrenal Hyperplasia ,Retrospective Studies ,biology ,Adrenal Hyperplasia, Congenital ,business.industry ,Incidence (epidemiology) ,Hyperandrogenism ,Biochemistry (medical) ,21-Hydroxylase ,Infant, Newborn ,Obstetrics and Gynecology ,Infant ,Retrospective cohort study ,General Medicine ,Hyperplasia ,medicine.disease ,Glucocorticoid therapy ,Child, Preschool ,biology.protein ,Female ,Steroid 21-Hydroxylase ,medicine.symptom ,Live birth ,business - Abstract
Many women with 21-hydroxylase (21-OH)-deficient nonclassic adrenal hyperplasia (NCAH) carry at least one allele containing a severe mutation of CYP21, and as such are at risk for giving birth to an infant having classic adrenal hyperplasia (CAH). Infants with NCAH typically are asymptomatic at birth, in contrast to those with CAH, but they do develop symptoms of hyperandrogenism later in childhood or as adults. This international multicenter study, conducted both retrospectively and prospectively, was an attempt to determine how often mothers with 21-OH-deficient NCAH bear infants having CAH or NCAH. The 101 women entering the study had a total of 203 pregnancies that could be evaluated. Fourteen tertiary referral centers in nine countries participated in the study. The diagnosis of 21-OH-deficient NCAH was based on a baseline or post-ACTH level of 17-hydroxyprogesterone exceeding 10 ng/mL. Where feasible, the offspring underwent genotypic analysis. Nearly half the women with NCAH presented with oligomenorrhea, and four had primary amenorrhea. More than two-thirds of pregnancies took place before the mother was diagnosed as having NCAH. Spontaneous miscarriages occurred in one-fourth of 138 pregnancies before NCAH was diagnosed but in only four of 65 pregnancies occurring after the diagnosis (6%). The incidence of CAH in 162 live births was 2.5%. Twenty-four children (15%) have been diagnosed as having NCAH. Five other female infants developed signs of hyperandrogenism but did not meet hormonal criteria for a diagnosis of NCAH. Three of the four live-bom CAH children were White Jewish or Hispanic, as were two of three NCAH mothers giving birth to a CAH child. In this international study, a woman with NCAH had a 2.5% chance of giving birth to a child having CAH and a 15% chance of having a child with NCAH. Preconception screening for 21-OH-deficient NCAH is especially important for hyperandrogenic or oligoovulatory women who wish to become pregnant. Glucocorticoid therapy before conception and/or before birth may favorably influence the outcome.
- Published
- 2006
39. What do we know about abnormally low prolactin levels in polycystic ovary syndrome? A narrative review.
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Cera N, Pinto J, and Pignatelli D
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- Humans, Female, Hyperprolactinemia blood, Hyperprolactinemia metabolism, Polycystic Ovary Syndrome metabolism, Polycystic Ovary Syndrome blood, Prolactin blood, Prolactin metabolism
- Abstract
Hyper and hypoprolactinemia seem to be related to the occurrence of metabolic alterations in PCOS patients. In contrast, between significantly elevated and significantly low, prolactin levels seem to be protective against metabolic consequences. In the present review, we found 4 studies investigating hypoprolactinemia in patients with PCOS. We also identified 6 additional studies that reported low levels of PRL in PCOS patients. Although its prevalence is not considered high (13.2-13.9%), its contribution is certainly significant to the metabolic alterations observed in PCOS (insulin resistance, obesity, diabetes mellitus, and fatty liver disease). Dopamine inhibits the secretion of prolactin and GnRH. If dopamine levels are low or the dopamine receptor is less expressed or mutated, the levels of prolactin and GnRH increase, and consequently, LH also increases. On the other hand, hyperprolactinemia, in prolactinomas-typical levels, acting through kisspeptin inhibition causes GnRH suppression and hypogonadotropic hypogonadism. In situations of hypoprolactinemia due to excessive dopamine agonist treatment, dosage reduction is important to minimize the decrease in prolactin levels. Nevertheless, there is a lack of prospective studies confirming these hypotheses, as well as randomized clinical trials with appropriate drugs targeting both hyperprolactin and hypoprolactin in patients with PCOS., Competing Interests: Declarations. Institutional Review Board Statement: Not applicable. Informed consent: Not applicable. Financial interests: The authors declare that they have no financial interests. Non-financial interests: None. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)
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- 2024
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40. Genetic architecture of congenital hypogonadotropic hypogonadism: insights from analysis of a Portuguese cohort.
- Author
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Carriço JN, Gonçalves CI, Al-Naama A, Syed N, Aragüés JM, Bastos M, Fonseca F, Borges T, Pereira BD, Pignatelli D, Carvalho D, Cunha F, Saavedra A, Rodrigues E, Saraiva J, Ruas L, Vicente N, Martin Martins J, De Sousa Lages A, Oliveira MJ, Castro-Correia C, Melo M, Martins RG, Couto J, Moreno C, Martins D, Oliveira P, Martins T, Martins SA, Marques O, Meireles C, Garrão A, Nogueira C, Baptista C, Gama-de-Sousa S, Amaral C, Martinho M, Limbert C, Barros L, Vieira IH, Sabino T, Saraiva LR, and Lemos MC
- Abstract
Study Question: What is the contribution of genetic defects in Portuguese patients with congenital hypogonadotropic hypogonadism (CHH)?, Summary Answer: Approximately one-third of patients with CHH were found to have a genetic cause for their disorder, with causal pathogenic and likely pathogenic germline variants distributed among 10 different genes; cases of oligogenic inheritance were also included., What Is Known Already: CHH is a rare and genetically heterogeneous disorder characterized by deficient production, secretion, or action of GnRH, LH, and FSH, resulting in delayed or absent puberty, and infertility., Study Design Size Duration: Genetic screening was performed on a cohort of 81 Portuguese patients with CHH (36 with Kallmann syndrome and 45 with normosmic hypogonadotropic hypogonadism) and 263 unaffected controls., Participants/materials Setting Methods: The genetic analysis was performed by whole-exome sequencing followed by the analysis of a virtual panel of 169 CHH-associated genes. The main outcome measures were non-synonymous rare sequence variants (population allele frequency <0.01) classified as pathogenic, likely pathogenic, and variants of uncertain significance (VUS)., Main Results and the Role of Chance: A genetic cause was identified in 29.6% of patients. Causal pathogenic and likely pathogenic variants were distributed among 10 of the analysed genes. The most frequently implicated genes were GNRHR , FGFR1 , ANOS1 , and CHD7 . Oligogenicity for pathogenic and likely pathogenic variants was observed in 6.2% of patients. VUS and oligogenicity for VUS variants were observed in 85.2% and 54.3% of patients, respectively, but were not significantly different from that observed in controls., Large Scale Data: N/A., Limitations Reasons for Caution: The identification of a large number of VUS presents challenges in interpretation and these may require reclassification as more evidence becomes available. Non-coding and copy number variants were not studied. Functional studies of the variants were not undertaken., Wider Implications of the Findings: This study highlights the genetic heterogeneity of CHH and identified several novel variants that expand the mutational spectrum of the disorder. A significant proportion of patients remained without a genetic diagnosis, suggesting the involvement of additional genetic, epigenetic, or environmental factors. The high frequency of VUS underscores the importance of cautious variant interpretation. These findings contribute to the understanding of the genetic architecture of CHH and emphasize the need for further studies to elucidate the underlying mechanisms and identify additional causes of CHH., Study Funding/competing Interests: This research was funded by the Portuguese Foundation for Science and Technology (grant numbers PTDC/SAU-GMG/098419/2008, UIDB/00709/2020, CEECINST/00016/2021/CP2828/CT0002, and 2020.04924.BD) and by Sidra Medicine-a member of the Qatar Foundation (grant number SDR400038). The authors declare no competing interests., Competing Interests: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.)
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- 2024
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41. European survey of diagnosis and management of the polycystic ovary syndrome: full report on the ESE PCOS Special Interest Group's 2023 Questionnaire.
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Livadas S, Yildiz BO, Mastorakos G, Gambineri A, Pignatelli D, Giorgino F, Andersen MS, Obermayer-Pietsch B, and Macut D
- Subjects
- Humans, Female, Adult, Europe epidemiology, Surveys and Questionnaires, Middle Aged, Young Adult, Endocrinologists, Endocrinology methods, Metformin therapeutic use, Polycystic Ovary Syndrome diagnosis, Polycystic Ovary Syndrome therapy
- Abstract
Background: Although polycystic ovary syndrome (PCOS) is a very common endocrinopathy, there are several issues related to this disorder which perplex clinicians in their everyday practice., Objective: To determine the current state of knowledge among European endocrinologists concerning the full spectrum of PCOS., Methods: An online survey comprising 41 items covering various aspects of PCOS diagnosis and management was distributed to members of the European Society of Endocrinology., Results: A total of 505 European endocrinologists (64% females), with a mean age of 47 ± 11.6 years, participated in the survey. The Rotterdam criteria were the primary diagnostic tool for 85% of respondents. Most referrals (87.1%) occurred between ages 20 and 40 years. Twenty-five percent of physicians have access to mass spectrometry for the evaluation of androgen levels. While an extended metabolic profile was commonly employed as part of the workup, there was uncertainty regarding chronic anovulation diagnosis. Diabetes, including gestational or type 2, was recognized as a significant risk factor with universal screening irrespective of BMI status. Lifestyle modification and metformin were considered as standard interventions by all participants alongside oral contraceptives, though there was significant discrepancy in treatment duration., Conclusions: The Rotterdam diagnostic criteria are widely adopted for PCOS diagnosis among European endocrinologists. The current updated survey shows an emphasis on steroid profiling as an important part of diagnostic workup and a strong position held for recognition of PCOS as a metabolic condition with potentially serious implications. Current therapy thus shifted to the demand for prioritizing lifestyle interventions and metabolic therapies, either as monotherapy or in combination with standard hormone compounds., Competing Interests: Conflict of interest: Coauthor A.G. is on the editorial board of EJE. A.G. was not involved in the review or editorial process for this paper, on which A.G. is listed as an author. The other authors have nothing to disclose., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
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- 2024
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42. The Complex Role Played by the Default Mode Network during Sexual Stimulation: A Cluster-Based fMRI Meta-Analysis.
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Pinto J, Comprido C, Moreira V, Maccarone MT, Cogoni C, Faustino R, Pignatelli D, and Cera N
- Abstract
The default mode network (DMN) is a complex network that plays a significant and active role during naturalistic stimulation. Previous studies that have used naturalistic stimuli, such as real-life stories or silent or sonorous films, have found that the information processing involved a complex hierarchical set of brain regions, including the DMN nodes. The DMN is not involved in low-level features and is only associated with high-level content-related incoming information. The human sexual experience involves a complex set of processes related to both external context and inner processes. Since the DMN plays an active role in the integration of naturalistic stimuli and aesthetic perception with beliefs, thoughts, and episodic autobiographical memories, we aimed at quantifying the involvement of the nodes of the DMN during visual sexual stimulation. After a systematic search in the principal electronic databases, we selected 83 fMRI studies, and an ALE meta-analysis was calculated. We performed conjunction analyses to assess differences in the DMN related to stimulus modalities, sex differences, and sexual orientation. The results show that sexual stimulation alters the topography of the DMN and highlights the DMN's active role in the integration of sexual stimuli with sexual schemas and beliefs.
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- 2024
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43. EndoBridge 2023: highlights and pearls.
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Yildiz BO, Boguszewski CL, da Silva Boguszewski MC, Busetto L, Celik O, Fuleihan GE, Goulis DG, Hammer GD, Haymart MR, Kaltsas G, Law JR, Lim AYL, Luger A, Macut D, McGowan B, McClung M, Miras AD, Patti ME, Peeters RP, Pignatelli D, Saeed H, Sipos J, Stratakis CA, Tsoli M, van der Lely AJ, Witchel SF, and Yazici D
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- Humans, Endocrinology history, Osteoporosis therapy, Endocrine System Diseases therapy
- Abstract
EndoBridge 2023 took place on October 20-22, 2023, in Antalya, Turkey. Accredited by the European Council, the 3-day scientific program of the 11
th Annual Meeting of EndoBridge included state-of-the-art lectures and interactive small group discussion sessions incorporating interesting and challenging clinical cases led by globally recognized leaders in the field and was well attended by a highly diverse audience. Following its established format over the years, the program provided a comprehensive update across all aspects of endocrinology and metabolism, including topics in pituitary, thyroid, bone, and adrenal disorders, neuroendocrine tumors, diabetes mellitus, obesity, nutrition, and lipid disorders. As usual, the meeting was held in English with simultaneous translation into Russian, Arabic, and Turkish. The abstracts of clinical cases presented by the delegates during oral and poster sessions have been published in JCEM Case Reports. Herein, we provide a paper on highlights and pearls of the meeting sessions covering a wide range of subjects, from thyroid nodule stratification to secondary osteoporosis and from glycemic challenges in post-bariatric surgery to male hypogonadism. This report emphasizes the latest developments in the field, along with clinical approaches to common endocrine issues. The 12th annual meeting of EndoBridge will be held on October 17-20, 2024 in Antalya, Turkey., (© 2024. The Author(s), under exclusive licence to Hellenic Endocrine Society.)- Published
- 2024
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44. The Role of Oxytocin in Polycystic Ovary Syndrome: A Systematic Review.
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Cera N, Pinto J, and Pignatelli D
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Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age, representing the primary cause of anovulatory infertility. The nonapeptide oxytocin (OT) plays an important role in cognitive, emotional, and reproductive functions in human beings. Oxytocin receptors are expressed in several body parts, including the ovaries. Despite this, the possible role played by oxytocin in symptoms of PCOS is not clear. The present systematic review aimed at understanding the presence of possible oxytocin level alterations in PCOS, the connection between alterations of OT levels and the symptoms of PCOS, and the effect of oxytocin administration in PCOS. After a systematic search in the principal databases, eight studies, five human and three animal, were included. Four human studies and one animal study highlighted the role played by oxytocin in fertility issues related to PCOS. Three human and two animal studies investigated the role of body weight and OT levels. Studies that analyzed oxytocin basal levels in women agreed that PCOS is associated with a reduction in the serum level of oxytocin. Two human studies and one animal study agreed about lower levels of oxytocin, confirming a possible implication of the dysfunction of OT in the pathogenesis of PCOS.
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- 2024
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45. Fetomaternal hemorrhage: a clue to intraplacental choriocarcinoma and neonatal malignancy.
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Simões M, Vale G, Lacerda C, Pais P, and Pignatelli D
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- Pregnancy, Infant, Newborn, Female, Humans, Fetomaternal Transfusion complications, Fetomaternal Transfusion diagnosis, Choriocarcinoma complications, Choriocarcinoma diagnosis, Choriocarcinoma pathology, Anemia, Neonatal complications, Fetal Diseases
- Abstract
Fetomaternal hemorrhage (FMH) is a known cause of neonatal anemia due to fetal blood loss to the maternal circulation, occurring when the maternal-fetal barrier is disrupted. Several causes must be considered, although in most cases the etiology remains unknown. Intraplacental choriocarcinoma (ICC) is a rare entity and has been related with massive FMH, intrauterine fetal demise, severe neonatal anemia and metastatic choriocarcinoma in both mother and infant. There are 25 cases of histopathologically confirmed ICC complicated with FMH described in the literature. Because FMH occurs unexpectedly and the majority of patients with ICC are asymptomatic, this diagnosis may be missed. Once FMH is confirmed, underlying malignancy should be kept in mind. The authors present a case report of severe neonatal anemia following FMH related to ICC and highlight the importance of serum β-hCG monitoring in cases of massive FMH.
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- 2022
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46. NOS1 mutations cause hypogonadotropic hypogonadism with sensory and cognitive deficits that can be reversed in infantile mice.
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Chachlaki K, Messina A, Delli V, Leysen V, Maurnyi C, Huber C, Ternier G, Skrapits K, Papadakis G, Shruti S, Kapanidou M, Cheng X, Acierno J, Rademaker J, Rasika S, Quinton R, Niedziela M, L'Allemand D, Pignatelli D, Dirlewander M, Lang-Muritano M, Kempf P, Catteau-Jonard S, Niederländer NJ, Ciofi P, Tena-Sempere M, Garthwaite J, Storme L, Avan P, Hrabovszky E, Carleton A, Santoni F, Giacobini P, Pitteloud N, and Prevot V
- Subjects
- Animals, Cognition, Gonadotropin-Releasing Hormone genetics, Gonadotropin-Releasing Hormone metabolism, Humans, Mice, Mutant Proteins, Mutation genetics, Nitric Oxide Synthase Type I genetics, Nitrites, Hypogonadism complications, Hypogonadism congenital, Hypogonadism genetics, Nitric Oxide
- Abstract
The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for reproduction. We hypothesized that a disruption of neuronal NO synthase (NOS1) activity underlies some forms of hypogonadotropic hypogonadism. Whole-exome sequencing was performed on a cohort of 341 probands with congenital hypogonadotropic hypogonadism to identify ultrarare variants in NOS1 . The activity of the identified NOS1 mutant proteins was assessed by their ability to promote nitrite and cGMP production in vitro. In addition, physiological and pharmacological characterization was carried out in a Nos1 -deficient mouse model. We identified five heterozygous NOS1 loss-of-function mutations in six probands with congenital hypogonadotropic hypogonadism (2%), who displayed additional phenotypes including anosmia, hearing loss, and intellectual disability. NOS1 was found to be transiently expressed by GnRH neurons in the nose of both humans and mice, and Nos1 deficiency in mice resulted in dose-dependent defects in sexual maturation as well as in olfaction, hearing, and cognition. The pharmacological inhibition of NO production in postnatal mice revealed a critical time window during which Nos1 activity shaped minipuberty and sexual maturation. Inhaled NO treatment at minipuberty rescued both reproductive and behavioral phenotypes in Nos1 -deficient mice. In summary, lack of NOS1 activity led to GnRH deficiency associated with sensory and intellectual comorbidities in humans and mice. NO treatment during minipuberty reversed deficits in sexual maturation, olfaction, and cognition in Nos1 mutant mice, suggesting a potential therapy for humans with NO deficiency.
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- 2022
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47. Modulation of Autophagy in Adrenal Tumors.
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Sousa D, Pereira SS, and Pignatelli D
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- Autophagy physiology, Cell Death, Humans, Adrenal Cortex Neoplasms drug therapy, Adrenal Gland Neoplasms drug therapy, Adrenal Gland Neoplasms pathology, Adrenocortical Carcinoma drug therapy
- Abstract
Adrenal masses are one of the most common tumors in humans. The majority are benign and non-functioning and therefore do not require immediate treatment. In contrast, the rare adrenal malignant tumors are often highly aggressive and with poor prognosis. Besides usually being detected in advanced stages, often already with metastases, one of the reasons of the unfavorable outcome of the patients with adrenal cancer is the absence of effective treatments. Autophagy is one of the intracellular pathways targeted by several classes of chemotherapeutics. Mitotane, the most commonly used drug for the treatment of adrenocortical carcinoma, was recently shown to also modulate autophagy. Autophagy is a continuous programmed cellular process which culminates with the degradation of cellular organelles and proteins. However, being a dynamic mechanism, understanding the autophagic flux can be highly complex. The role of autophagy in cancer has been described paradoxically: initially described as a tumor pro-survival mechanism, different studies have been showing that it may result in other outcomes, namely in tumor cell death. In adrenal tumors, this dual role of autophagy has also been addressed in recent years. Studies reported both induction and inhibition of autophagy as a treatment strategy of adrenal malignancies. Importantly, most of these studies were performed using cell lines. Consequently clinical studies are still required. In this review, we describe what is known about the role of autophagy modulation in treatment of adrenal tumors. We will also highlight the aspects that need further evaluation to understand the paradoxical role of autophagy in adrenal tumors., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Sousa, Pereira and Pignatelli.)
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- 2022
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48. Ang-Tie Angiogenic Pathway Is Distinctively Expressed in Benign and Malignant Adrenocortical Tumors.
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Oliveira S, Pereira SS, Costa MM, Monteiro MP, and Pignatelli D
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- Humans, Immunohistochemistry, Neovascularization, Pathologic genetics, Neovascularization, Pathologic metabolism, Vascular Endothelial Growth Factor A metabolism, Adrenal Cortex Neoplasms pathology, Adrenocortical Carcinoma pathology
- Abstract
The differential diagnosis between adrenocortical adenomas (ACAs) and adrenocortical carcinomas (ACCs) relies on unspecific clinical, imaging and histological features, and, so far, no single molecular biomarker has proved to improve diagnostic accuracy. Similarly, prognostic factors have an insufficient capacity to predict the heterogeneity of ACC clinical outcomes, which consequently lead to inadequate treatment strategies. Angiogenesis is a biological process regulated by multiple signaling pathways, including VEGF and the Ang-Tie pathway. Many studies have stressed the importance of angiogenesis in cancer development and metastasis. In the present study, we evaluated the expression of VEGF and Ang-Tie pathway mediators in adrenocortical tumors (ACTs), with the ultimate goal of assessing whether these molecules could be useful biomarkers to improve diagnostic accuracy and/or prognosis prediction in ACC. The expression of the proteins involved in angiogenesis, namely CD34, VEGF, VEGF-R2, Ang1, Ang2, Tie1 and Tie2, was assessed by immunohistochemistry in ACC ( n = 22), ACA with Cushing syndrome ( n = 8) and non-functioning ACA ( n = 13). ACC presented a significantly higher Ang1 and Ang2 expression when compared to ACA. Tie1 expression was higher in ACC with venous invasion and in patients with shorter overall survival. In conclusion, although none of these biomarkers showed to be useful for ACT diagnosis, the Ang-Tie pathway is active in ACT and may play a role in regulating ACT angiogenesis.
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- 2022
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49. A new standard scoring for interstitial pneumonia based on quantitative analysis of ultrasonographic data: A study on COVID-19 patients.
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Lombardi FA, Franchini R, Morello R, Casciaro E, Ianniello S, Serra M, Satriano F, Mojoli F, Mongodi S, Pignatelli D, Di Paola M, and Casciaro S
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, COVID-19 complications, Databases, Factual, Female, Humans, Lung Diseases, Interstitial classification, Lung Diseases, Interstitial complications, Male, Middle Aged, Sensitivity and Specificity, Surveys and Questionnaires, Young Adult, COVID-19 diagnostic imaging, Lung diagnostic imaging, Lung Diseases, Interstitial diagnostic imaging, Research Design standards, Ultrasonography methods
- Abstract
Objective: To assess the effectiveness of 3 novel lung ultrasound (LUS)-based parameters: Pneumonia Score and Lung Staging for pneumonia staging and COVID Index, indicating the probability of SARS-CoV-2 infection., Methods: Adult patients admitted to the emergency department with symptoms potentially related to pneumonia, healthy volunteers and clinical cases from online accessible databases were evaluated. The patients underwent a clinical-epidemiological questionnaire and a LUS acquisition, following a 14-zone protocol. For each zone, a Pneumonia score from 0 to 4 was assigned by the algorithm and by an expert operator (kept blind with respect to the algorithm results) on the basis of the identified imaging signs and the patient Lung Staging was derived as the highest observed score. The output of the operator was considered as the ground truth. The algorithm calculated also the COVID Index by combining the automatically identified LUS markers with the questionnaire answers and compared with the nasopharyngeal swab results., Results: Overall, 556 patients were analysed. A high agreement between the algorithm assignments and the expert operator evaluations was observed, both for Pneumonia Score and Lung Staging, with the latter having sensitivity and specificity over 92% both in the discrimination between healthy/sick patients and between sick patients with mild/severe pneumonia. Regarding the COVID Index, an area under the curve of 0.826 was observed for the classification of patients with/without SARS-CoV-2., Conclusion: The proposed methodology allowed the identification and staging of patients suffering from pneumonia with high accuracy. Moreover, it provided the probability of being infected by SARS-CoV-2., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Published
- 2021
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50. Pheochromocytomas and paragangliomas in von Hippel-Lindau disease: not a needle in a haystack.
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Castro-Teles J, Sousa-Pinto B, Rebelo S, and Pignatelli D
- Abstract
Objective: Pheochromocytomas are a hallmark feature of von Hippel-Lindau disease (vHL). To our knowledge, this is the first systematic review with meta-analysis evaluating the frequency of pheochromocytomas and/or paragangliomas (PPGLs) in patients with vHL, as well as among patients with different vHL subtypes., Design: Systematic review with meta-analysis., Methods: We searched on MEDLINE, Scopus, and Web of Science. We included primary studies assessing participants with vHL and reporting on the frequency of PPGL. We performed random-effects meta-analysis to quantitatively assess the frequency of PPGL, followed by meta-regression and subgroup analysis. Risk of bias analysis was performed to assess primary studies' methodological quality., Results: We included 80 primary studies. In 4263 patients with vHL, the pooled frequency of PPGL was 19.4% (95% CI = 15.9-23.6%, I2 = 86.1%). The frequency increased to 60.0% in patients with vHL type 2 (95% CI = 53.4-66.3%, I2 = 54.6%) and was determined to be of 58.2% in patients with vHL type 2A (95% CI = 49.7-66.3%, I2 = 36.2%), compared to 49.8% in vHL type 2B (95% CI = 39.9-59.7%, I2 = 42.7%), and 84.1% in vHL type 2C (95% CI = 75.1-93.1%, I2 = 0%). In meta-regression analysis, more recent studies were associated with a higher frequency of PPGL. All studies had at least one internal validity item classified as 'high risk of bias,' with 13% studies having low risk of bias in all external validity items., Conclusions: PPGLs are a common manifestation of vHL. Despite methodological limitations and differences across primary studies, our results point to the importance of PPGL screening in patients with vHL.
- Published
- 2021
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