401 results on '"Pietrzik, Claus U"'
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2. A novel mouse model for N-terminal truncated Aβ2-x generation through meprin β overexpression in astrocytes
3. The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
4. Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress
5. Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1
6. The Blood-Brain Barrier in Alzheimer’s Disease
7. LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease
8. Preparation and characterization of poly(ethylene glycol)-b-poly(tert-butyl methacrylate) micelles as potential nanocarriers for donepezil.
9. PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier
10. Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease
11. Brain endothelial LRP1 maintains blood–brain barrier integrity
12. The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM
13. The LepR-mediated leptin transport across brain barriers controls food reward
14. Degradome of soluble ADAM10 and ADAM17 metalloproteases
15. The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease
16. Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells
17. The Blood-Brain Barrier in Alzheimer’s Disease
18. Meprin β: A novel regulator of blood–brain barrier integrity
19. Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway
20. Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration
21. Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease: Theme: Drug Discovery, Development and Delivery in Alzheimer’s Disease Guest Editor: Davide Brambilla
22. Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model
23. Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing
24. Endothelial LRP1 transports amyloid-[β.sub.1-42] across the blood-brain barrier
25. Antibody‐mediated inhibition of tissue‐type plasminogen activator binding to the low‐density lipoprotein receptor‐related protein 1 as a potential beneficial modulator for stroke therapy.
26. Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells
27. The Metalloprotease Meprin β Generates Amino Terminal-truncated Amyloid β Peptide Species
28. Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo
29. Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation.
30. Expression of the ALS-Causing Variant hSOD1G93A Leads to an Impaired Integrity and Altered Regulation of Claudin-5 Expression in an in Vitro Blood–Spinal Cord Barrier Model
31. The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
32. The role of lipoprotein receptors on the physiological function of APP
33. The physiological functions of the β-amyloid precursor protein APP
34. APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms
35. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease
36. Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase
37. The Functional Role of the Second NPXY Motif of the LRP1 β-Chain in Tissue-type Plasminogen Activator-mediated Activation of N-Methyl-D-aspartate Receptors
38. LRP1 modulates APP trafficking along early compartments of the secretory pathway
39. Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription
40. Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis
41. Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
42. Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
43. Insensitivity to Aβ42-lowering Nonsteroidal Anti-inflammatory Drugs and γ-Secretase Inhibitors Is Common among Aggressive Presenilin-1 Mutations
44. The cytoplasmic domain of the LDL receptor‐related protein regulates multiple steps in APP processing
45. Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein
46. Cellular Prion Protein Participates in Amyloid-β Transcytosis across the Blood—Brain Barrier
47. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
48. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimerʼs disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure
49. Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures
50. Meprin β: A novel regulator of blood–brain barrier integrity
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