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20 results on '"Pietroboni, Anna Margherita"'

1. CSF sphingolipids are correlated with neuroinflammatory cytokines and differentiate neuromyelitis optica spectrum disorder from multiple sclerosis.

Author

Shi, Lisa, Ghezzi, Laura, Fenoglio, Chiara, Pietroboni, Anna Margherita, Galimberti, Daniela, Pace, Francesca, Hardy, Todd A., Piccio, Laura, and Don, Anthony S.

Subjects
NEUROMYELITIS optica, CHRONIC inflammatory demyelinating polyradiculoneuropathy, LDL cholesterol, NEUROLOGICAL disorders, MACROPHAGE migration inhibitory factor, FALSE discovery rate, OXIDATIVE phosphorylation
Published
2025
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7. A "glympse" into neurodegeneration: Diffusion MRI and cerebrospinal fluid aquaporin‐4 for the assessment of glymphatic system in Alzheimer's disease and other dementias.

Author

Sacchi, Luca, D'Agata, Federico, Campisi, Corrado, Arcaro, Marina, Carandini, Tiziana, Örzsik, Balázs, Dal Maschio, Vera Pacoova, Fenoglio, Chiara, Pietroboni, Anna Margherita, Ghezzi, Laura, Serpente, Maria, Pintus, Manuela, Conte, Giorgio, Triulzi, Fabio, Lopiano, Leonardo, Galimberti, Daniela, Cercignani, Mara, Bozzali, Marco, and Arighi, Andrea

Subjects
DIFFUSION magnetic resonance imaging, DIFFUSION tensor imaging, MAGNETIC resonance imaging, ALZHEIMER'S disease, AQUAPORINS
Abstract

The glymphatic system (GS) is a whole‐brain perivascular network, consisting of three compartments: the periarterial and perivenous spaces and the interposed brain parenchyma. GS dysfunction has been implicated in neurodegenerative diseases, particularly Alzheimer's disease (AD). So far, comprehensive research on GS in humans has been limited by the absence of easily accessible biomarkers. Recently, promising non‐invasive methods based on magnetic resonance imaging (MRI) along with aquaporin‐4 (AQP4) quantification in the cerebrospinal fluid (CSF) were introduced for an indirect assessment of each of the three GS compartments. We recruited 111 consecutive subjects presenting with symptoms suggestive of degenerative cognitive decline, who underwent 3 T MRI scanning including multi‐shell diffusion‐weighted images. Forty nine out of 111 also underwent CSF examination with quantification of CSF‐AQP4. CSF‐AQP4 levels and MRI measures—including perivascular spaces (PVS) counts and volume fraction (PVSVF), white matter free water fraction (FW‐WM) and mean kurtosis (MK‐WM), diffusion tensor imaging analysis along the perivascular spaces (DTI‐ALPS) (mean, left and right)—were compared among patients with AD (n = 47) and other neurodegenerative diseases (nAD = 24), patients with stable mild cognitive impairment (MCI = 17) and cognitively unimpaired (CU = 23) elderly people. Two runs of analysis were conducted, the first including all patients; the second after dividing both nAD and AD patients into two subgroups based on gray matter atrophy as a proxy of disease stage. Age, sex, years of education, and scanning time were included as confounding factors in the analyses. Considering the whole cohort, patients with AD showed significantly higher levels of CSF‐AQP4 (exp(b) = 2.05, p =.005) and FW‐WM FW‐WM (exp(b) = 1.06, p =.043) than CU. AQP4 levels were also significantly higher in nAD in respect to CU (exp(b) = 2.98, p <.001). CSF‐AQP4 and FW‐WM were significantly higher in both less atrophic AD (exp(b) = 2.20, p =.006; exp(b) = 1.08, p =.019, respectively) and nAD patients (exp(b) = 2.66, p =.002; exp(b) = 1.10, p =.019, respectively) compared to CU subjects. Higher total (exp(b) = 1.59, p =.013) and centrum semiovale PVS counts (exp(b) = 1.89, p =.016), total (exp(b) = 1.50, p =.036) and WM PVSVF (exp(b) = 1.89, p =.005) together with lower MK‐WM (exp(b) = 0.94, p =.006), mean and left ALPS (exp(b) = 0.91, p =.043; exp(b) = 0.88, p =.010 respectively) were observed in more atrophic AD patients in respect to CU. In addition, more atrophic nAD patients exhibited higher levels of AQP4 (exp(b) = 3.39, p =.002) than CU. Our results indicate significant changes in putative MRI biomarkers of GS and CSF‐AQP4 levels in AD and in other neurodegenerative dementias, suggesting a close interaction between glymphatic dysfunction and neurodegeneration, particularly in the case of AD. However, the usefulness of some of these biomarkers as indirect and standalone indices of glymphatic activity may be hindered by their dependence on disease stage and structural brain damage. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Association between enlarged perivascular spaces and cerebrospinal fluid aquaporin-4 and tau levels: report from a memory clinic

Author

Sacchi, Luca, primary, Arcaro, Marina, additional, Carandini, Tiziana, additional, Pietroboni, Anna Margherita, additional, Fumagalli, Giorgio Giulio, additional, Fenoglio, Chiara, additional, Serpente, Maria, additional, Sorrentino, Federica, additional, Visconte, Caterina, additional, Pintus, Manuela, additional, Conte, Giorgio, additional, Contarino, Valeria Elisa, additional, Scarpini, Elio, additional, Triulzi, Fabio, additional, Galimberti, Daniela, additional, and Arighi, Andrea, additional

Published
2023
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9. Banks of the Superior Temporal Sulcus in Alzheimer’s Disease: A Pilot Quantitative Susceptibility Mapping Study

Author

Sacchi, Luca, primary, Contarino, Valeria Elisa, additional, Siggillino, Silvia, additional, Carandini, Tiziana, additional, Fumagalli, Giorgio Giulio, additional, Pietroboni, Anna Margherita, additional, Arcaro, Marina, additional, Fenoglio, Chiara, additional, Orunesu, Eva, additional, Castellani, Massimo, additional, Casale, Silvia, additional, Conte, Giorgio, additional, Liu, Chunlei, additional, Triulzi, Fabio, additional, Galimberti, Daniela, additional, Scarpini, Elio, additional, and Arighi, Andrea, additional

Published
2023
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10. Teaching NeuroImage: Crowned Dens Syndrome

Author

Francia, Alessandro, primary, Conte, Giorgio, additional, Platania, Giulia, additional, Arighi, Andrea, additional, Pietroboni, Anna Margherita, additional, Fumagalli, Giorgio Giulio, additional, Floro, Stefano, additional, Scarpini, Elio, additional, Galimberti, Daniela, additional, Saetti, Maria Cristina, additional, and Carandini, Tiziana, additional

Published
2022
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11. Association of Superficial White Matter Alterations with Cerebrospinal Fluid Biomarkers and Cognitive Decline in Neurodegenerative Dementia

Author

Beeldverwerking ISI, Brain, Cancer, Contarino, Valeria Elisa, Siggillino, Silvia, Arighi, Andrea, Scola, Elisa, Fumagalli, Giorgio Giulio, Conte, Giorgio, Rotondo, Emanuela, Galimberti, Daniela, Pietroboni, Anna Margherita, Carandini, Tiziana, Leemans, Alexander, Bianchi, Anna Maria, Triulzi, Fabio Maria, Beeldverwerking ISI, Brain, Cancer, Contarino, Valeria Elisa, Siggillino, Silvia, Arighi, Andrea, Scola, Elisa, Fumagalli, Giorgio Giulio, Conte, Giorgio, Rotondo, Emanuela, Galimberti, Daniela, Pietroboni, Anna Margherita, Carandini, Tiziana, Leemans, Alexander, Bianchi, Anna Maria, and Triulzi, Fabio Maria

Published
2022

12. Unravelling the Association Between Amyloid-PET and Cerebrospinal Fluid Biomarkers in the Alzheimer’s Disease Spectrum: Who Really Deserves an A+?

Author

Sacchi, Luca, primary, Carandini, Tiziana, additional, Fumagalli, Giorgio Giulio, additional, Pietroboni, Anna Margherita, additional, Contarino, Valeria Elisa, additional, Siggillino, Silvia, additional, Arcaro, Marina, additional, Fenoglio, Chiara, additional, Zito, Felicia, additional, Marotta, Giorgio, additional, Castellani, Massimo, additional, Triulzi, Fabio, additional, Galimberti, Daniela, additional, Scarpini, Elio, additional, and Arighi, Andrea, additional

Published
2022
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13. Association of Superficial White Matter Alterations with Cerebrospinal Fluid Biomarkers and Cognitive Decline in Neurodegenerative Dementia

Author

Contarino, Valeria Elisa, primary, Siggillino, Silvia, additional, Arighi, Andrea, additional, Scola, Elisa, additional, Fumagalli, Giorgio Giulio, additional, Conte, Giorgio, additional, Rotondo, Emanuela, additional, Galimberti, Daniela, additional, Pietroboni, Anna Margherita, additional, Carandini, Tiziana, additional, Leemans, Alexander, additional, Bianchi, Anna Maria, additional, and Triulzi, Fabio Maria, additional

Published
2022
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14. Alemtuzumab in multiple sclerosis during the COVID-19 pandemic: A mild uncomplicated infection despite intense immunosuppression

Author

Carandini, Tiziana, primary, Pietroboni, Anna Margherita, additional, Sacchi, Luca, additional, De Riz, Milena Alessandra, additional, Pozzato, Mattia, additional, Arighi, Andrea, additional, Fumagalli, Giorgio Giulio, additional, Martinelli Boneschi, Filippo, additional, Galimberti, Daniela, additional, and Scarpini, Elio, additional

Published
2020
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15. MSJ926459_supplementary_material – Supplemental material for Alemtuzumab in multiple sclerosis during the COVID-19 pandemic: A mild uncomplicated infection despite intense immunosuppression

Author

Carandini, Tiziana, Pietroboni, Anna Margherita, Sacchi, Luca, Riz, Milena Alessandra De, Pozzato, Mattia, Arighi, Andrea, Fumagalli, Giorgio Giulio, Boneschi, Filippo Martinelli, Galimberti, Daniela, and Scarpini, Elio

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, MSJ926459_supplementary_material for Alemtuzumab in multiple sclerosis during the COVID-19 pandemic: A mild uncomplicated infection despite intense immunosuppression by Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Milena Alessandra De Riz, Mattia Pozzato, Andrea Arighi, Giorgio Giulio Fumagalli, Filippo Martinelli Boneschi, Daniela Galimberti and Elio Scarpini in Multiple Sclerosis Journal

Published
2020
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16. Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?

Author

Arighi, Andrea, primary, Di Cristofori, Andrea, additional, Fenoglio, Chiara, additional, Borsa, Stefano, additional, D’Anca, Marianna, additional, Fumagalli, Giorgio Giulio, additional, Locatelli, Marco, additional, Carrabba, Giorgio, additional, Pietroboni, Anna Margherita, additional, Ghezzi, Laura, additional, Carandini, Tiziana, additional, Colombi, Annalisa, additional, Scarioni, Marta, additional, De Riz, Milena Alessandra, additional, Serpente, Maria, additional, Rampini, Paolo Maria, additional, Scarpini, Elio, additional, and Galimberti, Daniela, additional

Published
2019
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17. Behavioral and Neurophysiological Effects of Transcranial Direct Current Stimulation (tDCS) in Fronto-Temporal Dementia

Author

Ferrucci, Roberta, primary, Mrakic-Sposta, Simona, additional, Gardini, Simona, additional, Ruggiero, Fabiana, additional, Vergari, Maurizio, additional, Mameli, Francesca, additional, Arighi, Andrea, additional, Spallazzi, Marco, additional, Barocco, Federica, additional, Michelini, Giovanni, additional, Pietroboni, Anna Margherita, additional, Ghezzi, Laura, additional, Fumagalli, Giorgio Giulio, additional, D'Urso, Giordano, additional, Caffarra, Paolo, additional, Scarpini, Elio, additional, Priori, Alberto, additional, and Marceglia, Sara, additional

Published
2018
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18. Word and Picture Version of the Free and Cued Selective Reminding Test (FCSRT): Is There Any Difference?

Author

Arighi, Andrea, primary, Carandini, Tiziana, additional, Mercurio, Matteo, additional, Carpani, Giovanni, additional, Pietroboni, Anna Margherita, additional, Fumagalli, Giorgio, additional, Ghezzi, Laura, additional, Basilico, Paola, additional, Calvi, Alberto, additional, Scarioni, Marta, additional, De Riz, Milena, additional, Fenoglio, Chiara, additional, Scola, Elisa, additional, Triulzi, Fabio, additional, Galimberti, Daniela, additional, and Scarpini, Elio, additional

Published
2017
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19. Word and Picture Version of the Free and Cued Selective Reminding Test (FCSRT): Is There Any Difference?

Author

Arighi, Andrea, Carandini, Tiziana, Mercurio, Matteo, Carpani, Giovanni, Pietroboni, Anna Margherita, Fumagalli, Giorgio, Ghezzi, Laura, Basilico, Paola, Calvi, Alberto, Scarioni, Marta, De Riz, Milena, Fenoglio, Chiara, Scola, Elisa, Triulzi, Fabio, Galimberti, Daniela, and Scarpini, Elio

Subjects
MAGNETIC resonance imaging, NEURODEGENERATION, ALZHEIMER'S disease, NEUROLOGIC examination, COGNITION disorders, NEUROPSYCHOLOGY, MILD cognitive impairment, DIGITAL image processing, LEARNING, NEUROPSYCHOLOGICAL tests, MEMORY, VOCABULARY, PROMPTS (Psychology)
Abstract

The Free and Cued Selective Reminding Test (FCSRT) is the most commonly used neuropsychological test to evaluate episodic memory. Two variants of FCSRT exist, using the recall of words (FCSRT-w) or pictures (FCSRT-p). Fourteen patients with mild cognitive impairment underwent neuropsychological evaluation and brain magnetic resonance. We found differences in FCSRT-w and FCSRT-p variants scores. FCSRT-p was correlated with atrophy in areas involved in visual stimuli processing while FCSRT-w was correlated to hippocampal atrophy. Our study suggests that FCSRT-w and FCSRT-p scores are not equivalent, but a larger cohort of patients is needed to validate these results. [ABSTRACT FROM AUTHOR]

Published
2018
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20. Behavioral and neurophysiological effects of transcranial direct current stimulation (tDCS) in fronto-temporal dementia

Author

Roberta Ferrucci, Simona Mrakic-Sposta, Simona Gardini, Fabiana Ruggiero, Maurizio Vergari, Francesca Mameli, Andrea Arighi, Marco Spallazzi, Federica Barocco, Giovanni Michelini, Anna Margherita Pietroboni, Laura Ghezzi, Giorgio Giulio Fumagalli, Giordano D'Urso, Paolo Caffarra, Elio Scarpini, Alberto Priori, Sara Marceglia, Ferrucci, Roberta, Mrakic-Sposta, Simona, Gardini, Simona, Ruggiero, Fabiana, Vergari, Maurizio, Mameli, Francesca, Arighi, Andrea, Spallazzi, Marco, Barocco, Federica, Michelini, Giovanni, Pietroboni, Anna Margherita, Ghezzi, Laura, Fumagalli, Giorgio Giulio, D'Urso, Giordano, Caffarra, Paolo, Scarpini, Elio, Priori, Alberto, and Marceglia, Sara

Subjects
medicine.medical_specialty, medicine.medical_treatment, Cognitive Neuroscience, EEG, Fronto-temporal dementia, Neuromodulation, Neuropsychiatric inventory, Reaction time, Transcranial direct current stimulation (tDCS), Neuropsychology and Physiological Psychology, Behavioral Neuroscience, Behavioral neuroscience, Cognitive neuroscience, Electroencephalography, Audiology, 050105 experimental psychology, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, Dementia, 0501 psychology and cognitive sciences, Effects of sleep deprivation on cognitive performance, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, medicine.diagnostic_test, Transcranial direct-current stimulation, business.industry, 05 social sciences, Cognition, medicine.disease, Brain stimulation, business, 030217 neurology & neurosurgery, Neuroscience
Abstract

Fronto-temporal dementia (FTD) is the clinical-diagnostic term that is now preferred to describe patients with a range of progressive dementia syndromes associated with focal atrophy of the frontal and anterior temporal cerebral regions. Currently available FTD medications have been used to control behavioral symptoms, even though they are ineffective in some patients, expensive and may induce adverse effects. Alternative therapeutic approaches are worth pursuing, such as non-invasive brain stimulation with transcranial direct current (tDCS). tDCS has been demonstrated to influence neuronal excitability and reported to enhance cognitive performance in dementia. The aim of this study was to investigate whether applying Anodal tDCS (2 mA intensity, 20 min) over the fronto-temporal cortex bilaterally in five consecutive daily sessions would improve cognitive performance and behavior symptoms in FTD patients, also considering the neuromodulatory effect of stimulation on cortical electrical activity measured through EEG. We recruited 13 patients with FTD and we tested the effect of Anodal and Sham (i.e., placebo) tDCS in two separate experimental sessions. In each session, at baseline (T0), after 5 consecutive days (T1), after 1 week (T2), and after 4 weeks (T3) from the end of the treatment, cognitive and behavioral functions were tested. EEG (21 electrodes, 10–20 international system) was recorded for 5 min with eyes closed at the same time points in nine patients. The present findings showed that Anodal tDCS applied bilaterally over the fronto-temporal cortex significantly improves (1) neuropsychiatric symptoms (as measured by the neuropsychiatric inventory, NPI) in FTD patients immediately after tDCS treatment, and (2) simple visual reaction times (sVRTs) up to 1 month after tDCS treatment. These cognitive improvements significantly correlate with the time course of the slow EEG oscillations (delta and theta bands) measured at the same time points. Even though further studies on larger samples are needed, these findings support the effectiveness of Anodal tDCS over the fronto-temporal regions in FTD on attentional processes that might be correlated to a normalized EEG low-frequency pattern.

Published
2018
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