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Aims The aim of this study was to assess the morphological characteristics and prognostic implications of the optical coherence tomography (OCT)-derived lipid core burden index (LCBI). Methods and results OCT-LCBI was assessed in 1003 patients with 1-year follow-up from the CLIMA multicentre registry using a validated software able to automatically obtain a maximum OCT-LCBI in 4 mm (maxOCT-LCBI4mm). Primary composite clinical endpoint included cardiac death, myocardial infarction, and target-vessel revascularization. A secondary analysis using clinical outcomes of CLIMA study was performed. Patients with a maxOCT-LCBI4mm ≥ 400 showed higher prevalence of fibrous cap thickness (FCT) <75 μm [odds ratio (OR) 1.43, 95% confidence interval (CI) 1.03–1.99; P = 0.034], lipid pool arc >180° (OR 3.93, 95%CI 2.97–5.21; P < 0.001), minimum lumen area <3.5 mm2 (OR 1.5, 95%CI 1.16–1.94; P = 0.002), macrophage infiltration (OR 2.38, 95%CI 1.81–3.13; P < 0.001), and intra-plaque intimal vasculature (OR 1.34, 95%CI 1.05–1.72; P = 0.021). A maxOCT-LCBI4mm ≥400 predicted the primary endpoint [adjusted hazard ratio (HR) 1.86, 95%CI 1.1–3.2; P = 0.019] as well as the CLIMA endpoint (HR 2.56, 95%CI 1.24–5.29; P = 0.011). Patients with high lipid content and thin FCT < 75 µm were at higher risk for adverse events (HR 4.88, 95%CI 2.44–9.72; P < 0.001). Conclusions A high maxOCT-LCBI4mm was related to poor outcome and vulnerable plaque features. This study represents a step further in the automated assessment of the coronary plaque risk profile. [ABSTRACT FROM AUTHOR]

Graph A 52-year-old gentleman, with systemic arterial hypertension, dyslipidaemia, diabetes mellitus, chronic coronary syndrome, and recent severe anaemia episode was referred to our hospital for ischaemic stroke. Cardiac-MR concluded for an uncertain lesion ( I Panel A and B i ), so vitamin K antagonist therapy was started and was stopped when PET-CT diagnosed the mass as a tumour. An angio-cerebral-CT showed numerous micro-ischaemic lesions. [Extracted from the article]

We report electroluminescence from ion-gel gated, field-effecttransistors based on the conjugated polymer, poly(9,9′-dioctylfluorene-co-benzothiadiazole)gated by an 1-ethyl-3-methylimidazoliumbis (trifluoromethylsulfonyl)imide/poly (styrene-block-ethylene oxide-block-styrene) ion gel, andinvestigate the mechanism for light emission. The devices emit lightfrom near the electron-injecting drain electrode when the drain sourcevoltage exceeds approximately the energy gap of the polymer (Vds> Eg/e). Charge accumulation spectroscopy is used to demonstratethe significantpenetration of the negative TFSI–ions into theF8BT assisted by the application of negative gate voltages, wherethey lead to significant p-type doping of the bulk of the F8BT film.In contrast, no evidence for diffusion of positive ions with positivegate voltages is observed, and this is consistent with the locationof the recombination zone in the proximity of electron injecting electrodeand the absence of a comparable electron current at positive gatevoltages. We conclude that in the light-emission regime the devicesoperate more akin to a hole-current dominated light-emitting electrochemicalcell than a transistor. [ABSTRACT FROM AUTHOR]