21 results on '"Pietila, Mikko"'
Search Results
2. Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch: the Nordic-Baltic Bifurcation Study IV
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Kumsars, Indulis, primary, Holm, Niels Ramsing, additional, Niemelä, Matti, additional, Erglis, Andrejs, additional, Kervinen, Kari, additional, Christiansen, Evald Høj, additional, Maeng, Michael, additional, Dombrovskis, Andis, additional, Abraitis, Vytautas, additional, Kibarskis, Aleksandras, additional, Trovik, Thor, additional, Latkovskis, Gustavs, additional, Sondore, Dace, additional, Narbute, Inga, additional, Terkelsen, Christian Juhl, additional, Eskola, Markku, additional, Romppanen, Hannu, additional, Laine, Mika, additional, Jensen, Lisette Okkels, additional, Pietila, Mikko, additional, Gunnes, Pål, additional, Hebsgaard, Lasse, additional, Frobert, Ole, additional, Calais, Fredrik, additional, Hartikainen, Juha, additional, Aarøe, Jens, additional, Ravkilde, Jan, additional, Engstrøm, Thomas, additional, Steigen, Terje K, additional, Thuesen, Leif, additional, and Lassen, Jens F, additional
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- 2020
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3. Determinants of functional recovery after myocardial infarction of patients treated with bone marrow-derived stem cells after thrombolytic therapy
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Miettinen, Johanna A., Ylitalo, Kari, Hedberg, Pirjo, Jokelainen, Jari, Kervinen, Kari, Niemela, Matti, Saily, Marjaana, Koistinen, Pirjo, Savolainen, Eeva-Riitta, Ukkonen, Heikki, Pietila, Mikko, Airaksinen, K.E. Juhani, Knuuti, Juhani, Vuolteenaho, Olli, Makikallio, Timo H., and Huikuri, Heikki V.
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Heart attack -- Care and treatment ,Heart attack -- Patient outcomes ,Stem cells -- Usage ,Stem cells -- Health aspects ,Thrombolytic therapy -- Usage ,Thrombolytic therapy -- Patient outcomes ,Health - Published
- 2010
4. European Society of Cardiology: Cardiovascular Disease Statistics 2017
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Timmis, Adam, Townsend, Nick, Gale, Chris, Grobbee, Rick, Maniadakis, Nikos, Flather, Marcus, Wilkins, Elizabeth, Wright, Lucy, Vos, Rimke, Bax, Jeroen, Blum, Maxim, Logstrup, Susanne, Pinto, Fausto J., Vardas, Panos, Goda, Artan, Demiraj, Aurel F, Weidinger, Franz, Metzler, Bernard, Ibrahimov, Firdovsi, Pasquet, Agnes A, Claeys, Marc, Thorton, Yolanda, Kusljugic, Zumreta, Smajic, Elnur, Velchev, Vasil, Ivanov, Nikolay, Antoniades, Loizos, Agathangelou, Petros, Táborský, Miloš, Gerdes, Christian, Viigima, Margus, Juhani, Pietila Mikko, Juilliere, Yves, Cattan, Simon, Aladashvili, Alexander, Hamm, Christian, Kuck, Karl-Heinz, Papoutsis, Konstantinos, Bestehorn, Kurt, Foussas, Stefanos, Giannoulidou, Georgia, Varounis, Christos, Kallikazaros, Ioannis, Kiss, Robert Gabor, Czétényi, Tunde, Becker, Dávid, Gudnason, Thorarinn, Kearney, Peter, McDonald, Kenneth, Rozenman, Yoseph, Ziv, Batia, Bolognese, Leonardo, Luciolli, Paola, Boriani, Giuseppe, Berkinbayev, Salim, Rakisheva, Amina, Mirrakhimov, Erkin, Erglis, Andrejs, Jegere, Sandra, Marinskis, Germanas, Beissel, Jean, Marchal, Nathalie, Kedev, Sasko, Xuereb, Robert G, Tilney, Terence, Felice, Tiziana, Popovici, Mihail, Mulder, Barbara, Simoons, Maarten, Elsendoorn, Moniek, Steigen, Terje K, Atar, Dan, Kalarus, Zbigniew, Tendera, Michal, Cardoso, Jose Silva, Ribeiro, José, Mateus, Cristina, Tatu-Chitoiu, Gabriel, Seferovic, Petar, Beleslin, Branko, Simkova, Iveta, Durcikova, Petra, Belicova, Veronica, Fras, Zlatko, Radelj, Sasa, Gonzalez Juanatey, Jose Ramon, Legendre, Sharon, Braunschweig, Frieder, Kaufmann, Urs Philipp, Rudiger-Sturchler, Marjam, Tokgozoglu, Lale, Unver, Ahmet, Kovalenko, Volodymir, Nesukay, Elena, Naum, Anastasia, de Courtelary, Paola Thellung, Martin, Stephan, Sebastiao, David, Ghislain, Daval, Bardinet, Isabel, and Repositório da Universidade de Lisboa
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medicine.medical_specialty ,Inequality ,media_common.quotation_subject ,Health infrastructure ,Disease ,030204 cardiovascular system & hematology ,European Society of Cardiology ,03 medical and health sciences ,0302 clinical medicine ,Economic indicator ,Internal medicine ,Health care ,Statistics ,medicine ,Cardiovascular disease ,Morbidity ,Mortality ,Risk factors ,Service provision ,Cardiology and Cardiovascular Medicine ,030212 general & internal medicine ,Disease burden ,Cause of death ,media_common ,business.industry ,medicine.disease ,Obesity ,Years of potential life lost ,Cardiology ,business - Abstract
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com., Aims: The European Society of Cardiology (ESC) Atlas has been compiled by the European Heart Agency to document cardiovascular disease (CVD) statistics of the 56 ESC member countries. A major aim of this 2017 data presentation has been to compare high-income and middle-income ESC member countries to identify inequalities in disease burden, outcomes, and service provision. Methods and results: The Atlas utilizes a variety of data sources, including the World Health Organization, the Institute for Health Metrics and Evaluation, and the World Bank to document risk factors, prevalence, and mortality of cardiovascular disease and national economic indicators. It also includes novel ESC-sponsored survey data of health infrastructure and cardiovascular service provision provided by the national societies of the ESC member countries. Data presentation is descriptive with no attempt to attach statistical significance to differences observed in stratified analyses. Important differences were identified between the high-income and middle-income member countries of the ESC with regard to CVD risk factors, disease incidence, and mortality. For both women and men, the age-standardized prevalence of hypertension was lower in high-income countries (18% and 27%) compared with middle-income countries (24% and 30%). Smoking prevalence in men (not women) was also lower (26% vs. 41%) and together these inequalities are likely to have contributed to the higher CVD mortality in middle-income countries. Declines in CVD mortality have seen cancer becoming a more common cause of death in a number of high-income member countries, but in middle-income countries declines in CVD mortality have been less consistent where CVD remains the leading cause of death. Inequalities in CVD mortality are emphasized by the smaller contribution they make to potential years of life lost in high-income countries compared with middle-income countries both for women (13% vs. 23%) and men (20% vs. 27%). The downward mortality trends for CVD may, however, be threatened by the emerging obesity epidemic that is seeing rates of diabetes increasing across all the ESC member countries. Survey data from the National Cardiac Societies showed that rates of cardiac catheterization and coronary artery bypass surgery, as well as the number of specialist centres required to deliver them, were greatest in the high-income member countries of the ESC. The Atlas confirmed that these ESC member countries, where the facilities for the contemporary treatment of coronary disease were best developed, were often those in which declines in coronary mortality have been most pronounced. Economic resources were not the only driver for delivery of equitable cardiovascular health care, as some middle-income ESC member countries reported rates for interventional procedures and device implantations that matched or exceeded the rates in wealthier member countries. Conclusion: In documenting national CVD statistics, the Atlas provides valuable insights into the inequalities in risk factors, health care delivery, and outcomes of CVD across the ESC member countries. The availability of these data will underpin the ESC’s ambitious mission ‘to reduce the burden of cardiovascular disease’ not only in its member countries but also in nation states around the world.
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- 2018
5. Computed tomography versus invasive coronary angiography: design and methods of the pragmatic randomised multicentre DISCHARGE trial
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Napp, Adriane E., Haase, Robert, Laule, Michael, Schuetz, Georg M., Rief, Matthias, Dreger, Henryk, Feuchtner, Gudrun, Friedrich, Guy, Spacek, Miloslav, Suchanek, Vojtech, Kofoed, Klaus Fuglsang, Engstroem, Thomas, Schroeder, Stephen, Drosch, Tanja, Gutberlet, Matthias, Woinke, Michael, Maurovich-Horvat, Pal, Merkely, Bela, Donnelly, Patrick, Ball, Peter, Dodd, Jonathan D., Quinn, Martin, Saba, Luca, Porcu, Maurizio, Francone, Marco, Mancone, Massimo, Erglis, Andrejs, Zvaigzne, Ligita, Jankauskas, Antanas, Sakalyte, Gintare, Haran, Tomasz, Ilnicka-Suckiel, Malgorzata, Bettencourt, Nuno, Gama-Ribeiro, Vasco, Condrea, Sebastian, Benedek, Imre, Adjic, Nada Cemerlic, Adjic, Oto, Rodriguez-Palomares, Jose, del Blanco, Bruno Garcia, Roditi, Giles, Berry, Colin, Davis, Gershan, Thwaite, Erica, Knuuti, Juhani, Pietila, Mikko, Kepka, Cezary, Kruk, Mariusz, Vidakovic, Radosav, Neskovic, Aleksandar N., Diez, Ignacio, Lecumberri, Inigo, Geleijns, Jacob, Kubiak, Christine, Strenge-Hesse, Anke, Do, The-Hoang, Fromel, Felix, Gutierrez-Ibarluzea, Inaki, Benguria-Arrate, Gaizka, Keiding, Hans, Katzer, Christoph, Mueller-Nordhorn, Jacqueline, Rieckmann, Nina, Walther, Mario, Schlattmann, Peter, Dewey, Marc, and DISCHARGE Trial Grp
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Male ,Cost-Benefit Analysis ,invasive coronary angiography ,Pilot Projects ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Chest pain ,Coronary Angiography ,Coronary artery disease ,0302 clinical medicine ,Outcome Assessment, Health Care ,angiography ,030212 general & internal medicine ,Myocardial infarction ,Computed tomography ,Computed tomography angiography ,Neuroradiology ,media_common ,medicine.diagnostic_test ,Angiography ,General Medicine ,Middle Aged ,Comparative effectiveness ,3. Good health ,Pre- and post-test probability ,Europe ,Female ,Radiology ,medicine.symptom ,medicine.medical_specialty ,comparative effectiveness ,nuclear medicine and imaging ,03 medical and health sciences ,medicine ,media_common.cataloged_instance ,Humans ,Radiology, Nuclear Medicine and imaging ,European union ,Aged ,Retrospective Studies ,business.industry ,Invasive coronary angiography ,computed tomography ,medicine.disease ,adverse events ,radiology ,radiology, nuclear medicine and imaging ,Adverse events ,Quality of Life ,business ,Tomography, X-Ray Computed ,Follow-Up Studies - Abstract
More than 3.5 million invasive coronary angiographies (ICA) are performed in Europe annually. Approximately 2 million of these invasive procedures might be reduced by noninvasive tests because no coronary intervention is performed. Computed tomography (CT) is the most accurate noninvasive test for detection and exclusion of coronary artery disease (CAD). To investigate the comparative effectiveness of CT and ICA, we designed the European pragmatic multicentre DISCHARGE trial funded by the 7th Framework Programme of the European Union (EC-GA 603266). In this trial, patients with a low-to-intermediate pretest probability (10–60 %) of suspected CAD and a clinical indication for ICA because of stable chest pain will be randomised in a 1-to-1 ratio to CT or ICA. CT and ICA findings guide subsequent management decisions by the local heart teams according to current evidence and European guidelines. Major adverse cardiovascular events (MACE) defined as cardiovascular death, myocardial infarction and stroke as a composite endpoint will be the primary outcome measure. Secondary and other outcomes include cost-effectiveness, radiation exposure, health-related quality of life (HRQoL), socioeconomic status, lifestyle, adverse events related to CT/ICA, and gender differences. The DISCHARGE trial will assess the comparative effectiveness of CT and ICA. • Coronary artery disease (CAD) is a major cause of morbidity and mortality. • Invasive coronary angiography (ICA) is the reference standard for detection of CAD. • Noninvasive computed tomography angiography excludes CAD with high sensitivity. • CT may effectively reduce the approximately 2 million negative ICAs in Europe. • DISCHARGE addresses this hypothesis in patients with low-to-intermediate pretest probability for CAD.
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- 2017
6. Cost-effectiveness analysis of stand-alone or combined non-invasive imaging tests for the diagnosis of stable coronary artery disease: results from the EVINCI study.
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Lorenzoni, Valentina, Bellelli, Stefania, Caselli, Chiara, Knuuti, Juhani, Underwood, Stephen Richard, Neglia, Danilo, Turchetti, Giuseppe, For the EVINCI Investigators, Pietila, Mikko, Mäki, Maija, Teresinska, Anna, Aguadé-Bruix, Santiago, Pizzi, Maria Nazarena, Todiere, Giancarlo, Gimelli, Alessia, Lombardi, Massimo, Puzzuoli, Stefano, Mangione, Maurizio, Marcheschi, Paolo, and Schroeder, Stephen
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CORONARY disease ,COMPUTED tomography ,CORONARY angiography ,MEDICAL care ,PATIENTS ,COST effectiveness ,RESEARCH funding ,ANIMALS - Abstract
Aim: This study aimed at evaluating the cost-effectiveness of different non-invasive imaging-guided strategies for the diagnosis of obstructive coronary artery disease (CAD) in a European population of patients from the Evaluation of Integrated Cardiac Imaging in Ischemic Heart Disease (EVINCI) study.Methods and Results: Cost-effectiveness analysis was performed in 350 patients (209 males, mean age 59 ± 9 years) with symptoms of suspected stable CAD undergoing computed tomography coronary angiography (CTCA) and at least one cardiac imaging stress-test prior to invasive coronary angiography (ICA) and in whom imaging exams were analysed at dedicated core laboratories. Stand-alone stress-tests or combined non-invasive strategies, when the first exam was uncertain, were compared. The diagnostic end-point was obstructive CAD defined as > 50% stenosis at quantitative ICA in the left main or at least one major coronary vessel. Effectiveness was defined as the percentage of correct diagnosis (cd) and costs were calculated using country-specific reimbursements. Incremental cost-effectiveness ratios (ICERs) were obtained using per-patient data and considering "no-imaging" as reference. The overall prevalence of obstructive CAD was 28%. Strategies combining CTCA followed by stress ECHO, SPECT, PET, or stress CMR followed by CTCA, were all cost-effective. ICERs values indicated cost saving from - 969€/cd for CMR-CTCA to - 1490€/cd for CTCA-PET, - 3092€/cd for CTCA-SPECT and - 3776€/cd for CTCA-ECHO. Similarly when considering early revascularization as effectiveness measure.Conclusion: In patients with suspected stable CAD and low prevalence of disease, combined non-invasive strategies with CTCA and stress-imaging are cost-effective as gatekeepers to ICA and to select candidates for early revascularization. [ABSTRACT FROM AUTHOR]- Published
- 2019
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7. Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population
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Liga, Riccardo, primary, Vontobel, Jan, additional, Rovai, Daniele, additional, Marinelli, Martina, additional, Caselli, Chiara, additional, Pietila, Mikko, additional, Teresinska, Anna, additional, Aguadé-Bruix, Santiago, additional, Pizzi, Maria Nazarena, additional, Todiere, Giancarlo, additional, Gimelli, Alessia, additional, Chiappino, Dante, additional, Marraccini, Paolo, additional, Schroeder, Stephen, additional, Drosch, Tanja, additional, Poddighe, Rosa, additional, Casolo, Giancarlo, additional, Anagnostopoulos, Constantinos, additional, Pugliese, Francesca, additional, Rouzet, Francois, additional, Le Guludec, Dominique, additional, Cappelli, Francesco, additional, Valente, Serafina, additional, Gensini, Gian Franco, additional, Zawaideh, Camilla, additional, Capitanio, Selene, additional, Sambuceti, Gianmario, additional, Marsico, Fabio, additional, Filardi, Pasquale Perrone, additional, Fernández-Golfín, Covadonga, additional, Rincón, Luis M., additional, Graner, Frank P., additional, de Graaf, Michiel A., additional, Stehli, Julia, additional, Reyes, Eliana, additional, Nkomo, Sandy, additional, Mäki, Maija, additional, Lorenzoni, Valentina, additional, Turchetti, Giuseppe, additional, Carpeggiani, Clara, additional, Puzzuoli, Stefano, additional, Mangione, Maurizio, additional, Marcheschi, Paolo, additional, Giannessi, Daniela, additional, Nekolla, Stephan, additional, Lombardi, Massimo, additional, Sicari, Rosa, additional, Scholte, Arthur J.H.A., additional, Zamorano, José L., additional, Underwood, S. Richard, additional, Knuuti, Juhani, additional, Kaufmann, Philipp A., additional, Neglia, Danilo, additional, and Gaemperli, Oliver, additional
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- 2016
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8. TCT-25 Randomized Comparison of Final Kissing Balloon Dilatation Versus No Final Kissing Balloon Dilatation in Patients With Coronary Bifurcation Lesions Treated With Main Vessel Stenting. Five Year Clinical Outcome in The Nordic-Baltic Bifurcation Study III
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Niemela, Matti J., primary, Holm, Niels R., additional, Kervinen, Kari, additional, Erglis, Andrejs, additional, Maeng, Michael, additional, Kumsars, Indulis, additional, Jegere, Sanda, additional, Steigen, Terje, additional, Eskola, Markku J., additional, Makikallio, Timo H., additional, Aaberge, Lars, additional, Jensen, Lisette Okkels, additional, Airaksinen, Juhani, additional, Pietila, Mikko, additional, Frobert, Ole, additional, Ravkilde, Jan, additional, Jensen, Svend Eggert, additional, Jensen, Jan S., additional, Helqvist, Steffen, additional, James, Stefan, additional, Miettinen, Heikki, additional, Lassen, Jens F., additional, Thuesen, Leif, additional, and Christiansen, Evald H., additional
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- 2015
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9. Detection of Significant Coronary Artery Disease by Noninvasive Anatomical and Functional Imaging
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Neglia, Danilo, primary, Rovai, Daniele, additional, Caselli, Chiara, additional, Pietila, Mikko, additional, Teresinska, Anna, additional, Aguadé-Bruix, Santiago, additional, Pizzi, Maria Nazarena, additional, Todiere, Giancarlo, additional, Gimelli, Alessia, additional, Schroeder, Stephen, additional, Drosch, Tanja, additional, Poddighe, Rosa, additional, Casolo, Giancarlo, additional, Anagnostopoulos, Constantinos, additional, Pugliese, Francesca, additional, Rouzet, Francois, additional, Le Guludec, Dominique, additional, Cappelli, Francesco, additional, Valente, Serafina, additional, Gensini, Gian Franco, additional, Zawaideh, Camilla, additional, Capitanio, Selene, additional, Sambuceti, Gianmario, additional, Marsico, Fabio, additional, Perrone Filardi, Pasquale, additional, Fernández-Golfín, Covadonga, additional, Rincón, Luis M, additional, Graner, Frank P, additional, de Graaf, Michiel A., additional, Fiechter, Michael, additional, Stehli, Julia, additional, Gaemperli, Oliver, additional, Reyes, Eliana, additional, Nkomo, Sandy, additional, Mäki, Maija, additional, Lorenzoni, Valentina, additional, Turchetti, Giuseppe, additional, Carpeggiani, Clara, additional, Marinelli, Martina, additional, Puzzuoli, Stefano, additional, Mangione, Maurizio, additional, Marcheschi, Paolo, additional, Mariani, Fabio, additional, Giannessi, Daniela, additional, Nekolla, Stephan, additional, Lombardi, Massimo, additional, Sicari, Rosa, additional, Scholte, Arthur J.H.A., additional, Zamorano, José L., additional, Kaufmann, Philipp A., additional, Underwood, S. Richard, additional, and Knuuti, Juhani, additional
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- 2015
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10. NONINVASIVE FRACTIONAL FLOW RESERVE DERIVED FROM QUANTITATIVE PERFUSION POSITRON EMISSION TOMOGRAPHY
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Stuijfzand, Wijnand, primary, Uusitalo, Valtteri, additional, Kero, Tanja, additional, Danad, Ibrahim, additional, Saraste, Antti, additional, Raijmakers, Pieter, additional, Lammertsma, Adriaan, additional, Marques, Koen, additional, Kajander, Sami, additional, Pietila, Mikko, additional, Sorensen, Jens, additional, Van Royen, Niels, additional, Knuuti, Juhani, additional, and Knaapen, Paul, additional
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- 2014
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11. Response to Letters Regarding Article, “Bacterial Signatures in Thrombus Aspirates of Patients With Myocardial Infarction”
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Pessi, Tanja, primary, Karhunen, Vesa, additional, Karjalainen, Pasi P., additional, Ylitalo, Antti, additional, Airaksinen, Juhani K., additional, Niemi, Matti, additional, Pietila, Mikko, additional, Lounatmaa, Kari, additional, Haapaniemi, Teppo, additional, Lehtimäki, Terho, additional, Laaksonen, Reijo, additional, Karhunen, Pekka J., additional, and Mikkelsson, Jussi, additional
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- 2013
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12. TCT-26 Randomized Comparison Of Final Kissing Balloon Dilatation Versus No Final Kissing Balloon Dilatation In Patients With Coronary Bifurcation Lesions Treated With Main Vessel Stenting. Three Year Clinical Outcome In The Nordic-Baltic Bifurcation Study III
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Holm, Niels R., primary, Kervinen, Kari, additional, Niemela, Matti J., additional, Erglis, Andrejs, additional, Kumsars, Indulis, additional, Steigen, Terje, additional, Christiansen, Evald H., additional, Eskola, Markku, additional, Romppanen, Hannu, additional, Dombrovskis, Andis, additional, Frobert, Ole, additional, Åberge, Lars, additional, Gunnes, Pål, additional, Airaksinen, Juhani, additional, Hervold, Anders, additional, Jegere, Sanda, additional, Trovik, Thor, additional, Jensen, Lisette Okkels, additional, Maeng, Michael, additional, Makikallio, Timo, additional, Pietila, Mikko, additional, Sjögren, Iwar, additional, Thayssen, Per, additional, Vikman, Saila, additional, Lassen, Jens F., additional, and Thuesen, Leif, additional
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- 2013
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13. Bacterial Signatures in Thrombus Aspirates of Patients With Myocardial Infarction
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Pessi, Tanja, primary, Karhunen, Vesa, additional, Karjalainen, Pasi P., additional, Ylitalo, Antti, additional, Airaksinen, Juhani K., additional, Niemi, Matti, additional, Pietila, Mikko, additional, Lounatmaa, Kari, additional, Haapaniemi, Teppo, additional, Lehtimäki, Terho, additional, Laaksonen, Reijo, additional, Karhunen, Pekka J., additional, and Mikkelsson, Jussi, additional
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- 2013
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14. Cardiac positron emission tomography imaging with [11C]hydroxyephedrine, a specific tracer for sympathetic nerve endings, and its functional correlates in congestive heart failure.
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Vesalainen, Risto K., Pietila, Mikko, Vesalainen, R K, Pietilä, M, Tahvanainen, K U, Jartti, T, Teräs, M, Någren, K, Lehikoinen, P, Huupponen, R, Ukkonen, H, Saraste, M, Knuuti, J, and Voipio-Pulkki, L M
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CONGESTIVE heart failure , *EPHEDRINE - Abstract
The integrative mechanisms of autonomic dysfunction in congestive heart failure (CHF) remain poorly understood. We sought to study cardiac retention of [11C]hydroxyephedrine (HED), a specific tracer for sympathetic presynaptic innervation, and its functional correlates in CHF. Thirty patients with mild to moderate heart failure underwent resting cardiac HED positron emission tomography imaging, spectrum analysis testing of systolic pressure and heart rate variability in the resting supine and 70 degrees head-up tilt positions, and testing of baroreflex sensitivity. Compared with control subjects, global myocardial HED retention index was reduced by 30% (p <0.01) in patients with CHF. The HED retention index did not correlate significantly with heart rate variability. However, it correlated with baroreflex sensitivity at rest (r = 0.43, p = 0.05) and with systolic pressure low-frequency (0.03 to 0.15 Hz) variability at head-up tilt (r = 0.76, p <0.01), as well as with low-frequency systolic pressure variability response from baseline to tilt (r = 0.75, p <0.01). We conclude that cardiac HED retention is reduced in patients with CHF. This correlates with blunted vascular sympathetic effector responses during posture-induced reflex activation and baroreflex control of heart rate, suggesting an interdependence between cardiac presynaptic innervation abnormalities and neural mechanisms important to blood pressure maintenance in CHF. [ABSTRACT FROM AUTHOR]
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- 1999
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15. Correction to: Cost‑effectiveness analysis of stand‑alone or combined non‑invasive imaging tests for the diagnosis of stable coronary artery disease: results from the EVINCI study.
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Lorenzoni, Valentina, Bellelli, Stefania, Caselli, Chiara, Knuuti, Juhani, Underwood, Stephen Richard, Neglia, Danilo, Turchetti, Giuseppe, For the EVINCI Investigators, Pietila, Mikko, Mäki, Maija, Teresinska, Anna, Aguadé-Bruix, Santiago, Pizzi, Maria Nazarena, Todiere, Giancarlo, Gimelli, Alessia, Lombardi, Massimo, Puzzuoli, Stefano, Mangione, Maurizio, Marcheschi, Paolo, and Schroeder, Stephen
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CORONARY disease ,MEDICAL care - Abstract
In the Published article, the value in the abstract has been published incorrectly. The correct abstract section is as follows. [ABSTRACT FROM AUTHOR]
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- 2019
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16. Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population
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Liga, Riccardo, Vontobel, Jan, Rovai, Daniele, Marinelli, Martina, Caselli, Chiara, Pietila, Mikko, Teresinska, Anna, Aguadé-Bruix, Santiago, Pizzi, Maria Nazarena, Todiere, Giancarlo, Gimelli, Alessia, Chiappino, Dante, Marraccini, Paolo, Schroeder, Stephen, Drosch, Tanja, Poddighe, Rosa, Casolo, Giancarlo, Anagnostopoulos, Constantinos, Pugliese, Francesca, Rouzet, Francois, Le Guludec, Dominique, Cappelli, Francesco, Valente, Serafina, Gensini, Gian Franco, Zawaideh, Camilla, Capitanio, Selene, Sambuceti, Gianmario, Marsico, Fabio, Filardi, Pasquale Perrone, Fernández-Golfín, Covadonga, Rincón, Luis M., Graner, Frank P., de Graaf, Michiel A., Stehli, Julia, Reyes, Eliana, Nkomo, Sandy, Mäki, Maija, Lorenzoni, Valentina, Turchetti, Giuseppe, Carpeggiani, Clara, Puzzuoli, Stefano, Mangione, Maurizio, Marcheschi, Paolo, Giannessi, Daniela, Nekolla, Stephan, Lombardi, Massimo, Sicari, Rosa, Scholte, Arthur J.H.A., Zamorano, José L., Underwood, S. Richard, Knuuti, Juhani, Kaufmann, Philipp A., Neglia, Danilo, Gaemperli, Oliver, and Investigators, The EVINCI Study
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Aims Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting.Methods and results Fourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with fractional flow reserve (FFR). Hybrid MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab analyses were performed for CTCA, MPS, QCA and hybrid datasets. Hemodynamically significant CAD was ruled-in non-invasively in the presence of a matched finding (myocardial perfusion defect co-localized with stenosed coronary artery) and ruled-out with normal findings (both CTCA and MPS normal). Overall prevalence of significant CAD on QCA (>70% stenosis or 30-70% with FFR≤0.80) was 37%. Of 1004 pathological myocardial segments on MPS, 246 (25%) were reclassified from their standard coronary distribution to another territory by hybrid imaging. In this respect, in 45/252 (18%) patients, hybrid imaging reassigned an entire perfusion defect to another coronary territory, changing the final diagnosis in 42% of the cases. Hybrid imaging allowed non-invasive CAD rule-out in 41%, and rule-in in 24% of patients, with a negative and positive predictive value of 88% and 87%, respectively.Conclusion In patients at intermediate risk of CAD, hybrid imaging allows non-invasive co-localization of myocardial perfusion defects and subtending coronary arteries, impacting clinical decision-making in almost one every five subjects.- Published
- 2016
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17. Abnormalities of cardiac autonomic function and 11 C-hydroxyephedrine PET coincide in heart failure
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Voipio-Pulkki, Liisa-Maria, Vesalainen, Risto, Pietila¨, Mikko, Jartti, Tuomas, Ukkonen, Heikki, Tera¨s, Mike, Na˚gren, Kjell, Lehikoinen, Pertti, Knuuti, Juhani, and Tahvanainen, Kari
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- 1996
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18. Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population
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Danilo Neglia, Valentina Lorenzoni, Rosa Poddighe, Francesco Cappelli, Arthur J.H.A. Scholte, Anna Teresinska, María Nazarena Pizzi, Riccardo Liga, Juhani Knuuti, Luis M. Rincón, Chiara Caselli, Philipp A. Kaufmann, Giancarlo Todiere, Stefano Puzzuoli, Stephen Schroeder, Jan Vontobel, Julia Stehli, Pasquale Perrone Filardi, Daniela Giannessi, Michiel A. de Graaf, Eliana Reyes, Sandy Nkomo, Selene Capitanio, Constantinos Anagnostopoulos, Alessia Gimelli, José Luis Zamorano, Covadonga Fernández-Golfín, Frank P. Graner, Dante Chiappino, Gianmario Sambuceti, Maija Mäki, Maurizio Mangione, Paolo Marraccini, Daniele Rovai, Fabio Marsico, Giuseppe Turchetti, Serafina Valente, Oliver Gaemperli, Martina Marinelli, Francesca Pugliese, Clara Carpeggiani, Massimo Lombardi, P. Marcheschi, Tanja Drosch, Santiago Aguadé-Bruix, Dominique Le Guludec, Gian Franco Gensini, François Rouzet, Mikko Pietilä, Stephan G. Nekolla, Camilla Zawaideh, S. Richard Underwood, Giancarlo Casolo, Rosa Sicari, Liga, Riccardo, Vontobel, Jan, Rovai, Daniele, Marinelli, Martina, Caselli, Chiara, Pietila, Mikko, Teresinska, Anna, Aguadé-Bruix, Santiago, Pizzi, Maria Nazarena, Todiere, Giancarlo, Gimelli, Alessia, Chiappino, Dante, Marraccini, Paolo, Schroeder, Stephen, Drosch, Tanja, Poddighe, Rosa, Casolo, Giancarlo, Anagnostopoulos, Constantino, Pugliese, Francesca, Rouzet, Francoi, Le Guludec, Dominique, Cappelli, Francesco, Valente, Serafina, Gensini, Gian Franco, Zawaideh, Camilla, Capitanio, Selene, Sambuceti, Gianmario, Marsico, Fabio, Filardi, Pasquale Perrone, Fernández-Golfn, Covadonga, Rincón, Luis M., Graner, Frank P., De Graaf, Michiel A., Stehli, Julia, Reyes, Eliana, Nkomo, Sandy, Mäki, Maija, Lorenzoni, Valentina, Turchetti, Giuseppe, Carpeggiani, Clara, Puzzuoli, Stefano, Mangione, Maurizio, Marcheschi, Paolo, Giannessi, Daniela, Nekolla, Stephan, Lombardi, Massimo, Sicari, Rosa, Scholte, Arthur J. H. A., Zamorano, Jose L., Underwood, S. Richard, Knuuti, Juhani, Kaufmann, Philipp A., Neglia, Danilo, and Gaemperli, Oliver
- Subjects
Male ,Radiology, Nuclear Medicine and Imaging ,Internationality ,Computed Tomography Angiography ,CT coronary angiography ,Myocardial Ischemia ,Fractional flow reserve ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Myocardial perfusion scintigraphy ,Multimodal Imaging ,Coronary artery disease ,EVINCI Study Investigators ,030218 nuclear medicine & medical imaging ,Cohort Studies ,Computer-Assisted ,0302 clinical medicine ,Retrospective Studie ,Tomography ,Cardiac imaging ,health care economics and organizations ,Computed tomography angiography ,Observer Variation ,education.field_of_study ,medicine.diagnostic_test ,Statistics ,Myocardial Perfusion Imaging ,General Medicine ,Middle Aged ,Fractional Flow Reserve ,3. Good health ,Europe ,Fractional Flow Reserve, Myocardial ,medicine.anatomical_structure ,Cardiology ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,Population ,Sensitivity and Specificity ,Hybrid imaging ,Aged ,Humans ,Positron-Emission Tomography ,Retrospective Studies ,Statistics, Nonparametric ,Tomography, Emission-Computed, Single-Photon ,Image Interpretation, Computer-Assisted ,03 medical and health sciences ,Myocardial perfusion imaging ,Internal medicine ,medicine ,Medical imaging ,Myocardial ,Nonparametric ,education ,Image Interpretation ,business.industry ,Original Articles ,ta3121 ,medicine.disease ,Coronary arteries ,Emission-Computed ,Cohort Studie ,business ,Single-Photon - Abstract
Aims Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting. Methods and results Fourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with fractional flow reserve (FFR). Hybrid MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab analyses were performed for CTCA, MPS, QCA and hybrid datasets. Hemodynamically significant CAD was ruled-in non-invasively in the presence of a matched finding (myocardial perfusion defect colocalized with stenosed coronary artery) and ruled-out with normal findings (both CTCA and MPS normal). Overall prevalence of significant CAD on QCA (.70% stenosis or 30-70% with FFR≤0.80) was 37%. Of 1004 pathological myocardial segments on MPS, 246 (25%) were reclassified from their standard coronary distribution to another territory by hybrid imaging. In this respect, in 45/252 (18%) patients, hybrid imaging reassigned an entire perfusion defect to another coronary territory, changing the final diagnosis in 42% of the cases. Hybrid imaging allowed non-invasive CAD rule-out in 41%, and rule-in in 24% of patients, with a negative and positive predictive value of 88% and 87%, respectively. Conclusion In patients at intermediate risk of CAD, hybrid imaging allows non-invasive co-localization of myocardial perfusion defects and subtending coronary arteries, impacting clinical decision-making in almost one every five subjects. -------------------------------------------------------------------------------------------------------------------------------
- Published
- 2016
19. A New Integrated Clinical-Biohumoral Model to PredictFunctionally Significant Coronary Artery Disease inPatients With Chronic Chest Pain
- Author
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Caselli, C., Rovai, D., Lorenzoni, V., Carpeggiani, C., Teresinska, A., Aguade, S., Todiere, G., Gimelli, A., Schroeder, S., Casolo, G., Poddighe, R., Pugliese, F., Guludec, D. le, Valente, S., Sambuceti, G., Perrone-Filardi, P., Ry, S. del, Marinelli, M., Nekolla, S., Pietila, M., Lombardi, M., Sicari, R., Scholte, A., Zamorano, J., Kaufmann, P.A., Underwood, S.R., Knuuti, J., Giannessi, D., Neglia, D., EVINCI Study Investigators, Caselli, Chiara, Rovai, Daniele, Lorenzoni, Valentina, Carpeggiani, Clara, Teresinska, Anna, Aguade, Santiago, Todiere, Giancarlo, Gimelli, Alessia, Schroeder, Stephen, Casolo, Giancarlo, Poddighe, Rosa, Pugliese, Francesca, Le Guludec, Dominique, Valente, Serafina, Sambuceti, Gianmario, PERRONE FILARDI, Pasquale, Del Ry, Silvia, Marinelli, Martina, Nekolla, Stephan, Pietila, Mikko, Lombardi, Massimo, Sicari, Rosa, Scholte, Arthur, Zamorano, José, Kaufmann, Philipp A, Underwood, S. Richard, Knuuti, Juhani, Giannessi, Daniela, and Neglia, Danilo
- Subjects
Male ,Predictive Value of Test ,Coronary Disease ,Fractional flow reserve ,Chest pain ,Coronary Angiography ,Severity of Illness Index ,Coronary artery disease ,Cohort Studies ,Prospective Studies ,Prospective cohort study ,Multivariate Analysi ,biology ,Medicine (all) ,Angina Pectori ,Middle Aged ,Fractional Flow Reserve ,Aged ,Analysis of Variance ,Angina Pectoris ,Aspartate Aminotransferases ,Biomarkers ,C-Reactive Protein ,Chest Pain ,Cholesterol, HDL ,Chronic Disease ,Female ,Fractional Flow Reserve, Myocardial ,Humans ,Multivariate Analysis ,Predictive Value of Tests ,ROC Curve ,Reproducibility of Results ,Risk Assessment ,Sex Factors ,Cardiology and Cardiovascular Medicine ,Pre- and post-test probability ,Cholesterol ,Biological Markers ,Predictive value of tests ,Cardiology ,medicine.symptom ,Human ,medicine.medical_specialty ,HDL ,Reproducibility of Result ,Internal medicine ,Severity of illness ,medicine ,Myocardial ,business.industry ,C-reactive protein ,Aspartate Aminotransferase ,Biomarker ,ta3121 ,medicine.disease ,Prospective Studie ,biology.protein ,Cohort Studie ,business - Abstract
In patients with chronic angina-like chest pain, the probability of coronary artery disease (CAD) is estimated by symptoms, age, and sex according to the Genders clinical model. We investigated the incremental value of circulating biomarkers over the Genders model to predict functionally significant CAD in patients with chronic chest pain.In 527 patients (60.4 years, standard deviation, 8.9 years; 61.3% male participants) enrolled in the European Evaluation of Integrated Cardiac Imaging (EVINCI) study, clinical and biohumoral data were collected.Functionally significant CAD-ie, obstructive coronary disease seen at invasive angiography causing myocardial ischemia at stress imaging or associated with reduced fractional flow reserve (FFR0.8), or both-was present in 15.2% of patients. High-density lipoprotein (HDL) cholesterol, aspartate aminotransferase (AST) levels, and high-sensitivity C-reactive protein (hs-CRP) were the only independent predictors of disease among 31 biomarkers analyzed. The model integrating these biohumoral markers with clinical variables outperformed the Genders model by receiver operating characteristic curve (ROC) (area under the curve [AUC], 0.70 [standard error (SE), 0.03] vs 0.58 [SE, 0.03], respectively, P0.001) and reclassification analysis (net reclassification improvement, 0.15 [SE, 0.07]; P = 0.04). Cross-validation of the ROC analysis confirmed the discrimination ability of the new model (AUC, 0.66). As many as 56% of patients who were assigned to a higher pretest probability by the Genders model were correctly reassigned to a low probability class (15%) by the new integrated model.The Genders model has a low accuracy for predicting functionally significant CAD. A new model integrating HDL cholesterol, AST, and hs-CRP levels with common clinical variables has a higher predictive accuracy for functionally significant CAD and allows the reclassification of patients from an intermediate/high to a low pretest likelihood of CAD.
- Published
- 2015
20. Multicentre multi-device hybrid imaging study of coronary artery disease: results from the EValuation of INtegrated Cardiac Imaging for the Detection and Characterization of Ischaemic Heart Disease (EVINCI) hybrid imaging population.
- Author
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Liga R, Vontobel J, Rovai D, Marinelli M, Caselli C, Pietila M, Teresinska A, Aguadé-Bruix S, Pizzi MN, Todiere G, Gimelli A, Chiappino D, Marraccini P, Schroeder S, Drosch T, Poddighe R, Casolo G, Anagnostopoulos C, Pugliese F, Rouzet F, Le Guludec D, Cappelli F, Valente S, Gensini GF, Zawaideh C, Capitanio S, Sambuceti G, Marsico F, Filardi PP, Fernández-Golfín C, Rincón LM, Graner FP, de Graaf MA, Stehli J, Reyes E, Nkomo S, Mäki M, Lorenzoni V, Turchetti G, Carpeggiani C, Puzzuoli S, Mangione M, Marcheschi P, Giannessi D, Nekolla S, Lombardi M, Sicari R, Scholte AJ, Zamorano JL, Underwood SR, Knuuti J, Kaufmann PA, Neglia D, and Gaemperli O
- Subjects
- Aged, Cohort Studies, Computed Tomography Angiography methods, Coronary Angiography methods, Coronary Artery Disease physiopathology, Europe, Female, Humans, Internationality, Male, Middle Aged, Myocardial Ischemia physiopathology, Myocardial Perfusion Imaging methods, Observer Variation, Positron-Emission Tomography methods, Retrospective Studies, Sensitivity and Specificity, Statistics, Nonparametric, Tomography, Emission-Computed, Single-Photon methods, Coronary Artery Disease diagnostic imaging, Fractional Flow Reserve, Myocardial physiology, Image Interpretation, Computer-Assisted, Multimodal Imaging methods, Myocardial Ischemia diagnostic imaging
- Abstract
Aims: Hybrid imaging provides a non-invasive assessment of coronary anatomy and myocardial perfusion. We sought to evaluate the added clinical value of hybrid imaging in a multi-centre multi-vendor setting., Methods and Results: Fourteen centres enrolled 252 patients with stable angina and intermediate (20-90%) pre-test likelihood of coronary artery disease (CAD) who underwent myocardial perfusion scintigraphy (MPS), CT coronary angiography (CTCA), and quantitative coronary angiography (QCA) with fractional flow reserve (FFR). Hybrid MPS/CTCA images were obtained by 3D image fusion. Blinded core-lab analyses were performed for CTCA, MPS, QCA and hybrid datasets. Hemodynamically significant CAD was ruled-in non-invasively in the presence of a matched finding (myocardial perfusion defect co-localized with stenosed coronary artery) and ruled-out with normal findings (both CTCA and MPS normal). Overall prevalence of significant CAD on QCA (>70% stenosis or 30-70% with FFR≤0.80) was 37%. Of 1004 pathological myocardial segments on MPS, 246 (25%) were reclassified from their standard coronary distribution to another territory by hybrid imaging. In this respect, in 45/252 (18%) patients, hybrid imaging reassigned an entire perfusion defect to another coronary territory, changing the final diagnosis in 42% of the cases. Hybrid imaging allowed non-invasive CAD rule-out in 41%, and rule-in in 24% of patients, with a negative and positive predictive value of 88% and 87%, respectively., Conclusion: In patients at intermediate risk of CAD, hybrid imaging allows non-invasive co-localization of myocardial perfusion defects and subtending coronary arteries, impacting clinical decision-making in almost one every five subjects., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.)
- Published
- 2016
- Full Text
- View/download PDF
21. Neointimal coverage and vasodilator response to titanium-nitride-oxide-coated bioactive stents and everolimus-eluting stents in patients with acute coronary syndrome: insights from the BASE-ACS trial.
- Author
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Karjalainen P, Kiviniemi TO, Lehtinen T, Nammas W, Ylitalo A, Saraste A, Mikkelsson J, Pietila M, Biancari F, and Airaksinen JK
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- Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome physiopathology, Coronary Circulation, Echocardiography, Doppler, Color, Echocardiography, Doppler, Pulsed, Everolimus, Humans, Hyperplasia, Percutaneous Coronary Intervention adverse effects, Predictive Value of Tests, Prospective Studies, Prosthesis Design, Single-Blind Method, Sirolimus administration & dosage, Time Factors, Treatment Outcome, Acute Coronary Syndrome therapy, Cardiovascular Agents administration & dosage, Coated Materials, Biocompatible, Coronary Vessels diagnostic imaging, Coronary Vessels pathology, Coronary Vessels physiopathology, Drug-Eluting Stents, Neointima, Percutaneous Coronary Intervention instrumentation, Sirolimus analogs & derivatives, Stents, Titanium, Tomography, Optical Coherence, Vasodilation
- Abstract
Incomplete stent endothelialization is associated with late and very late stent thrombosis. In a post hoc analysis of the BASE-ACS trial, we sought to assess neointimal coverage and coronary flow reserve (CFR) 9 months after implantation of titanium-nitride-oxide-coated bioactive stents (BAS) versus everolimus-eluting stents (EES) in patients with acute coronary syndrome (ACS). In the BASE-ACS trial, 827 patients with ACS were randomized to receive either BAS or EES. In the current study, we examined neointimal growth and strut coverage by optical coherence tomography and CFR by trans-thoracic echocardiography in 28 consecutive non-diabetic patients with the culprit lesion in the left anterior descending coronary artery. The primary endpoints were binary stent strut coverage and CFR at 9-month follow-up. A total of 13 patients were included in the BAS group (2,033 struts); 15 in the EES group (2,898 struts). Binary stent strut coverage was higher and malapposed struts lower with BAS versus EES (99.4 vs 89.2, and 0.2 vs 4.6%, respectively, p < 0.001 for both). Neointimal hyperplasia thickness was greater with BAS versus EES (274.2 vs 100.1 μm, respectively, p < 0.001). CFR was lower with EES versus BAS (2.2 ± 0.8 vs. 3.0 ± 0.5, respectively, p = 0.001). Abnormal CFR (<2.5) were detected in 10 patients in the EES group versus one in the BAS group (p = 0.002). The current study demonstrated that in patients with ACS, BAS resulted in improved neointimal stent strut coverage and better coronary vasodilator function as compared with EES at 9-month follow-up.
- Published
- 2013
- Full Text
- View/download PDF
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