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Your search keyword '"Pieter van de Woestijne"' showing total 6 results
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6 results on '"Pieter van de Woestijne"'

1. An unusual case of redo tricuspid valve replacement and repair of a previously unidentified anomalous pulmonary venous return in a patient with congenitally corrected transposition of the great arteries

Author

Amir H. Sadeghi, Pieter Van de Woestijne, Yannick J.H.J. Taverne, Arie P. J. Van Dijk, and Ad J. J. C. Bogers

Subjects
congenitally corrected transposition of the great arteries, congenital cardiac malformation, partial anomalous pulmonary venous return, redo cardiac surgery, Medicine, Medicine (General), R5-920
Abstract

Abstract Associated cardiovascular malformations in congenitally corrected transposition of the great arteries (CCTGA) should not be missed when a patient requires surgical correction. We present a case of an adult CCTGA patient who required redo surgery for recurrent tricuspid (left atrioventricular) valve regurgitation and previously unidentified partial anomalous pulmonary venous return.

Published
2020
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2. An IL-1β driven neutrophil-stromal cell axis fosters a BAFF-rich microenvironment in multiple myeloma

Author

Madelon M.E. de Jong, Cathelijne Fokkema, Natalie Papazian, Teddie van Heusden, Michael Vermeulen, Remco Hoogenboezem, Gregory van Beek, Sabrin Tahri, Mathijs A. Sanders, Pieter van de Woestijne, Francesca Gay, Philippe Moreau, Maike Büttner-Herold, Heiko Bruns, Mark van Duin, Annemiek Broijl, Pieter Sonneveld, and Tom Cupedo

Abstract

SummaryThe bone marrow permanently harbors high numbers of neutrophils, and a tumor-supportive bias of these cells could significantly impact bone marrow-confined malignancies. In multiple myeloma, the bone marrow is characterized by inflammatory stromal cells with the potential to influence neutrophils. We investigated myeloma-associated alterations in marrow neutrophils and the impact of stromal inflammation on neutrophil function. Mature neutrophils in myeloma marrow are activated and tumor-supportive, transcribing increased levels of IL-1β, and myeloma cell survival factor BAFF. Interactions with inflammatory stromal cells can induce neutrophil activation, including BAFF secretion, in a STAT3-dependent manner and once activated, neutrophils gain the ability to reciprocally induce stromal activation. After first-line myeloid-depleting treatment, patient bone marrow retains residual stromal inflammation and newly-formed neutrophils are reactivated. Combined, we identify a neutrophil-stromal cell feed-forward loop driving tumor-supportive inflammation that persists after treatment and warrants novel strategies to target both stromal and immune microenvironments in multiple myeloma.

Published
2023
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4. OAB-029: Single-cell transcriptomic analysis reveals reduction of cytotoxic NK cells in a subset of newly diagnosed multiple myeloma patients impacting outcome after daratumumab therapy

Author

Sabrin Tahri, Madelon de Jong, Cathelijne Fokkema, Natalie Papazian, Zoltan Kellermayer, Chelsea Den Hollander, Michael Vermeulen, Mark van Duin, Pieter van de Woestijne, Kazem Nasserinejad, Elona Saraci, Mattia D’Agostino, Francesca Gay, Vincent Van der Velden, Sonja Zweegman, Niels W.C.J. van de Donk, Annemiek Broijl, Pieter Sonneveld, and Tom Cupedo

Subjects
Cancer Research, Oncology, Hematology
Published
2022
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