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pnd - rethinking planning 2021(2), 29-44 (2021). doi:10.18154/RWTH-2021-10415 special issue: "Digital Citymakers : Co-creating the City in Times of Digital Transformation = Digitale Stadtmacher : Gemeinsam Stadt machen in Zeiten digitaler Transformation / edited by Martin Bangratz and Agnes F��rster", Published by Rektor der RWTH Aachen University, Aachen

This paper presents the findings from a case study of a grants programme aimed at growing service design practice within a mental health network. The case study employed a ‘grants plus’ model, offering both money and coaching support, to promote the use of service design and build ‘communities of practice’ around this common approach within the organisation. The authors reflect on the findings from two grants programmes and share the advantages and challenges of building a design community through a funded model. This offers learning for those trying to scale Service Design practice across organisations or communities, as well as anyone trying to encourage the use of the process with other teams or organisations where there is a perceived power imbalance.

This paper will reflect on the role of design approaches, in a time of austerity and a time when this practice is more and more used by Governments and communities around the world to influence what next for our societies. By building on the case study of Mind, a UK based mental health charity, and their vision of embedding Design in the organisation, the paper will present and reflect on the opportunities and risks of introducing collaborative forms of design in public services and in society.

Service Design in Mind (SDiM) is a programme run by Mind, the national mental health charity. The programme aims to embed service design techniques and methods into a network of local voluntary organisations that deliver mental health services. This case study describes how the programme, based on the idea that everybody designs and everyone can be a designer, aimed to create a diffused design culture (Manzini, 2015) across the charity and its network. By capitalising on existing internal design expertise and sensibility, Mind developed a bespoke design approach and a set of resources, as well as skills and capabilities to improve and transform mental health services.

BACKGROUND AND AIMS It is paramount to identify predictors of treatment failure with direct antiviral agents in 'field-practice' patients, including people who inject drugs (PWID). Data on the efficacy of glecaprevir/pibrentasvir (GLE/PIB) in a field-practice scenario are scant. The multicentre MISTRAL study enrolled 1177 patients, including PWID, to assess real-life efficacy and safety of GLE/PIB and to identify the predictive factors for this treatment. METHODS This was a prospective, longitudinal study. The outcome variable was the rate of sustained virological response (SVR) at week 12. RESULTS A total of 123 patients (10%) were infected from hepatitis C virus (HCV) 3. METAVIR fibrosis score was F4 in 104 subjects (9%); 118 patients (10%) were PWID. Overall, 1163/1177 (99%) patients achieved SVR. The baseline clinical factors discriminating between treatment success and treatment failure were age at treatment (P = 0.031) and creatinine level (P = 0.034). SVR rates were not influenced by gender, substance abuse, previous treatment, treatment duration, fibrosis or chronic kidney disease stage. Compared with non-substance users, the 118 PWID exhibited a significantly different genotype pattern distribution (χ2