152 results on '"Pieper PG"'
Search Results
2. Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect
- Author
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Yap, S-C, Drenthen, W, Meijboom, FJ, Moons, P, Mulder, BJM, Vliegen, HW, van Dijk, APJ, Jaddoe, VWV, Steegers, EAP, Roos-Hesselink, JW, and Pieper, PG
- Published
- 2009
- Full Text
- View/download PDF
3. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
- Author
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Regitz-Zagrosek, V, Roos-Hesselink, JW, Bauersachs, J, Blomström-Lundqvist, C, Cífková, R, De Bonis, M, Iung, B, Johnson, MR, Kintscher, U, Kranke, P, Lang, IM, Morais, J, Pieper, PG, Presbitero, P, Price, S, Rosano, GMC, Seeland, U, Simoncini, T, Swan, L, Warnes, CA, Deaton, C, Simpson, IA, Aboyans, V, Agewall, S, Barbato, E, Calda, P, Coca, A, Coman, IM, De Backer, J, Delgado, V, Di Salvo, G, Fitzsimmons, S, Fitzsimons, D, Garbi, M, Gevaert, S, Hindricks, G, Jondeau, G, Kluin, J, Lionis, C, McDonagh, TA, Meier, P, Moons, P, Pantazis, A, Piepoli, MF, Rocca, B, Roffi, M, Rosenkranz, S, Sarkozy, A, Shlyakhto, E, Silversides, CK, Sliwa, K, Sousa-Uva, M, Tamargo, J, Thorne, S, Van de Velde, M, Williams, B, Zamorano, JL, Windecker, S, Bueno, H, Collet, J-P, Dean, V, Gaemperli, O, Jüni, P, Katus, HA, Knuuti, J, Lancellotti, P, Leclercq, C, Ponikowski, P, Richter, DJ, Hammoudi, N, Piruzyan, A, Mascherbauer, J, Samadov, F, Prystrom, A, Pasquet, A, Caluk, J, Gotcheva, N, Skoric, B, Heracleous, H, Vejlstrup, N, Maser, M, Kaaja, RJ, Srbinovska-Kostovska, E, Mounier-Vehier, C, Vakhtangadze, T, Rybak, K, Giannakoulas, G, Kiss, RG, Thrainsdottir, IS, Erwin, RJ, Porter, A, Geraci, G, Ibrahimi, P, Lunegova, O, Mintale, I, Kadri, Z, Benlamin, H, Barysiene, J, Banu, CA, Caruana, M, Gratii, C, Haddour, L, Bouma, BJ, Estensen, M-E, Hoffman, P, Petris, AO, Moiseeva, O, Bertelli, L, Tesic, BV, Dubrava, J, Koželj, M, Prieto-Arévalo, R, Furenäs, E, Schwerzmann, M, Mourali, MS, Ozer, N, Mitchenko, O, Nelson-Piercy, C, Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomstrom-Lundqvist, C., Cifkova, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., Lang, I. M., Morais, J., Pieper, P. G., Presbitero, P., Price, S., Rosano, G. M. C., Seeland, U., Simoncini, T., Swan, L., Warnes, C. A., Regitz-Zagrosek, Vera, Roos-Hesselink, Jolien W, Bauersachs, Johann, Blomström-Lundqvist, Carina, Cífková, Renata, De Bonis, Michele, Iung, Bernard, Johnson, Mark Richard, Kintscher, Ulrich, Kranke, Peter, Lang, Irene Marthe, Morais, Joao, Pieper, Petronella G, Presbitero, Patrizia, Price, Susanna, Rosano, Giuseppe MC, Seeland, Ute, Simoncini, Tommaso, Swan, Lorna, Warnes, Carole A, and Cardiology
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Counseling ,Prenatal Diagnosi ,030204 cardiovascular system & hematology ,Guideline ,Cardiovascular ,0302 clinical medicine ,Pregnancy ,Prenatal Diagnosis ,030212 general & internal medicine ,1102 Cardiorespiratory Medicine and Haematology ,Societies, Medical ,Risk assessment ,Advisory Committee ,Advisory Committees ,Cardiology ,Cardiovascular Agents ,Europe ,Female ,Humans ,Poland ,Pregnancy Complications, Cardiovascular ,Practice Guidelines as Topic ,valvular heart disease ,Cardiovascular disease ,Management ,Hypertension ,Drug therapy ,Cardiology and Cardiovascular Medicine ,Arrhythmia ,Human ,medicine.medical_specialty ,Settore BIO/14 - FARMACOLOGIA ,Cardiomyopathy ,Heart failure ,Cardiovascular therapy ,Pulmonary hypertension ,Aortic pathology ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Medical ,medicine ,Cardiovascular diagnosis ,Intensive care medicine ,Congenital heart disease ,Pharmacology ,business.industry ,ta3121 ,medicine.disease ,Valvular heart disease ,Pregnancy Complications ,Cardiovascular System & Hematology ,Cardiovascular Agent ,Societies ,business - Published
- 2019
4. Uteroplacental Doppler flow and pregnancy outcome in women with tetralogy of Fallot
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Kampman, MAM, Siegmund, AS, Bilardo, CM, Veldhuisen, DJ, Balci, A, Oudijk, MA, Groen, H, Mulder, BJM, Roos - Hesselink, Jolien, Sieswerda, G, de Laat, MWM, Sollie-Szarynska, KM, Pieper, PG, Reproductive Origins of Adult Health and Disease (ROAHD), Cardiovascular Centre (CVC), Methods in Medicines evaluation & Outcomes research (M2O), Value, Affordability and Sustainability (VALUE), Amsterdam Reproduction & Development (AR&D), Obstetrics and Gynaecology, Cardiology, APH - Personalized Medicine, APH - Aging & Later Life, and ACS - Heart failure & arrhythmias
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CONGENITAL HEART-DISEASE ,PREECLAMPSIA ,COMPLICATIONS ,pregnancy outcome ,CARDIAC-FUNCTION ,BLOOD-FLOW ,UTERINE ARTERY DOPPLER ,REPAIRED TETRALOGY ,utcroplacental Doppler flow ,congenital heart disease ,DYSFUNCTION ,SURGICAL-CORRECTION ,REFERENCE RANGES - Abstract
Pregnancy in women with surgically corrected tetralogy of Fallot (ToF) is associated with cardiac, obstetric and neonatal complications. We compared uteroplacental Doppler flow (UDF) measurements and pregnancy outcome in women with ToF and in healthy women and aimed to assess whether a relationship exists between cardiac function and UDF in women with ToF. We evaluated prospectively pregnant women with ToF and healthy pregnant women from the ZAHARA studies. Clinical evaluation, standardized echocardiography and UDF measurements were performed at 20 and 32 weeks' gestation. We included 62 women with ToF and 69 healthy controls. Cardiac complications, mostly arrhythmia, occurred in 8.1% of women with ToF. There was a higher incidence of small-for-gestational age (21.0% vs 4.4%, P = 0.004) and low birth weight (16.1% vs 2.9%, P = 0.009) in the group of women with ToF than in healthy controls. In women with ToF, early diastolic notching of uterine artery waveform at 20 and 32 weeks occurred more frequently (9.8% vs 1.5%, P = 0.034 and 7.0% vs 0%, P = 0.025, respectively) and the umbilical artery pulsatility index at 32 weeks was higher (1.02 ± 0.20 vs 0.94 ± 0.17, P = 0.015) than in healthy controls. Right ventricular function parameters prepregnancy and at 20 weeks' gestation were significantly associated with abnormal UDF. UDF parameters were associated with adverse neonatal outcome. The majority of women with surgically corrected ToF tolerate pregnancy well. However, UDF indices are more frequently abnormal in these women, suggesting impaired placentation. The association of impaired right ventricular function parameters with abnormal UDF suggests that cardiac dysfunction contributes to defective placentation or placental perfusion mismatch and may explain the increased incidence of obstetric and neonatal complications. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd
- Published
- 2017
5. Proposal for a Revised Definition of Dilated Cardiomyopathy and its Implications for Clinical Practice: A Position Statement of the ESC Working Group on Myocardial and Pericardial Diseases
- Author
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Pinto, Ym, Elliott, Pm, Arbustini, E, Adler, Y, Anastasakis, A, Böhm, M, Duboc, D, Gimeno, J, de Groote, P, Imazio, M, Heymans, S, Klingel, K, Komajda, M, Limongelli, G, Linhart, A, Mogensen, J, Moon, J, Pieper, Pg, Seferovic, Pm, Schueler, S, Zamorano, Jl, Caforio, A, and Charron, P.
- Published
- 2016
6. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010)
- Author
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Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Gatzoulis MA, Gohlke Baerwolf C, Kaemmerer H, Kilner P, Meijboom F, Mulder BJ, Oechslin E, Oliver JM, Serraf A, Szatmari A, Thaulow E, Vouhe PR, Walma E, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck Brentano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P, Swan L, Andreotti F, Beghetti M, Borggrefe M, Bozio A, Brecker S, Budts W, Hess J, Hirsch R, Jondeau G, Kokkonen J, Kozelj M, Kucukoglu S, Laan M, Lionis C, Metreveli I, Moons P, Pieper PG, Pilossoff V, Popelova J, Price S, Roos Hesselink J, Uva MS, Tornos P, Trindade PT, Ukkonen H, Walker H, Webb GD, Westby J, Task Force on the Management of Grown up Congenital Heart Disease of the European Society of Cardiology, GALIE', NAZZARENO, Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Galie N, Gatzoulis MA, Gohlke-Baerwolf C, Kaemmerer H, Kilner P, Meijboom F, Mulder BJ, Oechslin E, Oliver JM, Serraf A, Szatmari A, Thaulow E, Vouhe PR, Walma E, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck-Brentano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P, Swan L, Andreotti F, Beghetti M, Borggrefe M, Bozio A, Brecker S, Budts W, Hess J, Hirsch R, Jondeau G, Kokkonen J, Kozelj M, Kucukoglu S, Laan M, Lionis C, Metreveli I, Moons P, Pieper PG, Pilossoff V, Popelova J, Price S, Roos-Hesselink J, Uva MS, Tornos P, Trindade PT, Ukkonen H, Walker H, Webb GD, Westby J, and Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC)
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CONGENITAL HEART DISEASE ,GUIDELINES ,management - Abstract
not available
- Published
- 2010
7. Aangeboren hartafwijkingen bij volwassen
- Author
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Meijboom, FJ (Folkert), Bogers, Ad, Mulder, BJM, Pieper, PG, Meijboom, FJ, Hamer, JPM, Cardiology, and Cardiothoracic Surgery
- Published
- 2013
8. Guidelines on the management of valvular heart disease (version 2012): The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)
- Author
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Vahanian, A, Alfieri, O, Andreotti, F, Antunes, Mj, Barón Esquivias, G, Baumgartner, H, Borger, Ma, Carrel, Tp, De Bonis, M, Evangelista, A, Falk, V, Iung, B, Lancellotti, P, Pierard, L, Price, S, Schäfers, Hj, Schuler, G, Stepinska, J, Swedberg, K, Takkenberg, J, Von Oppell UO, Windecker, S, Zamorano, Jl, Zembala, M, ESC Committee for Practice Guidelines, Bax, Jj, Ceconi, Claudio, Dean, V, Deaton, C, Fagard, R, Funck Brentano, C, Hasdai, D, Hoes, A, Kirchhof, P, Knuuti, J, Kolh, P, Mcdonagh, T, Moulin, C, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Tendera, M, Torbicki, A, Document, Reviewers, Von Segesser, L, Badano, Lp, Bunc, M, Claeys, Mj, Drinkovic, N, Filippatos, G, Habib, G, Kappetein, Ap, Kassab, R, Lip, Gy, Moat, N, Nickenig, G, Otto, Cm, Pepper, J, Piazza, N, Pieper, Pg, Rosenhek, R, Shuka, N, Schwammenthal, E, Schwitter, J, Mas, Pt, Trindade, Pt, and Walther, T.
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NO - Published
- 2012
9. ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC)
- Author
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Regitz Zagrosek, V, Blomstrom Lundqvist, C, Borghi, C, Cifkova, R, Ferreira, R, Foidart, Jm, Gibbs, Js, Gohlke Baerwolf, C, Gorenek, B, Iung, B, Kirby, M, Maas, Ah, Morais, J, Nihoyannopoulos, P, Pieper, Pg, Presbitero, P, Roos Hesselink JW, Schaufelberger, M, Seeland, U, Torracca, L, ESC Committee for Practice Guidelines, Bax, J, Auricchio, A, Baumgartner, H, Ceconi, Claudio, Dean, V, Deaton, C, Fagard, R, Funck Brentano, C, Hasdai, D, Hoes, A, Knuuti, J, Kolh, P, Mcdonagh, T, Moulin, C, Poldermans, D, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Torbicki, A, Vahanian, A, Windecker, S, Document, Reviewers, Aguiar, C, Al Attar, N, Garcia, Aa, Antoniou, A, Coman, I, Elkayam, U, Gomez Sanchez MA, Gotcheva, N, Hilfiker Kleiner, D, Kiss, Rg, Kitsiou, A, Konings, Kt, Lip, Gy, Manolis, A, Mebaaza, A, Mintale, I, Morice, Mc, Mulder, Bj, Pasquet, A, Price, S, Priori, Sg, Salvador, Mj, Shotan, A, Silversides, Ck, Skouby, So, Stein, Ji, Tornos, P, Vejlstrup, N, Walker, F, Warnes, C., ACS - Amsterdam Cardiovascular Sciences, and Cardiology
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Counseling ,medicine.medical_specialty ,Peripartum cardiomyopathy ,Heart disease ,Heart Diseases ,Pregnancy Complications, Cardiovascular ,Aortic Diseases ,Coronary artery disease ,Pregnancy ,Internal medicine ,Prenatal Diagnosis ,Medicine ,Humans ,cardiovascular diseases ,Pregnancy Complications, Infectious ,Framingham Risk Score ,business.industry ,Contraindications ,valvular heart disease ,Atrial fibrillation ,Abortion, Induced ,Cardiovascular Agents ,Prenatal Care ,Venous Thromboembolism ,medicine.disease ,Heart failure ,Cardiovascular agent ,Hypertension ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Table 1. Classes of recommendation Table 2. Levels of evidence Table 3. Estimated fetal and maternal effective doses for various diagnostic and interventional radiology procedures Table 4. Predictors of maternal cardiovascular events and risk score from the CARPREG study Table 5. Predictors of maternal cardiovascular events identified in congential heart diseases in the ZAHARA and Khairy study Table 6. Modified WHO classification of maternal cardiovascular risk: principles Table 7. Modified WHO classification of maternal cardiovascular risk: application Table 8. Maternal predictors of neonatal events in women with heart disease Table 9. General recommendations Table 10. Recommendations for the management of congenital heart disease Table 11. Recommendations for the management of aortic disease Table 12. Recommendations for the management of valvular heart disease Table 13. Recommendations for the management of coronary artery disease Table 14. Recommendations for the management of cardiomyopathies and heart failure Table 15. Recommendations for the management of arrhythmias Table 16. Recommendations for the management of hypertension Table 17. Check list for risk factors for venous thrombo-embolism Table 18. Prevalence of congenital thrombophilia and the associated risk of venous thrombo-embolism during pregnancy Table 19. Risk groups according to risk factors: definition and preventive measures Table 20. Recommendations for the prevention and management of venous thrombo-embolism in pregnancy and puerperium Table 21. Recommendations for drug use ABPM : ambulatory blood pressure monitoring ACC : American College of Cardiology ACE : angiotensin-converting enzyme ACS : acute coronary syndrome AF : atrial fibrillation AHA : American Heart Association aPTT : activated partial thromboplastin time ARB : angiotensin receptor blocker AS : aortic stenosis ASD : atrial septal defect AV : atrioventricular AVSD : atrioventricular septal defect BMI : body mass index BNP : B-type natriuretic peptide BP : blood pressure CDC : Centers for Disease Control CHADS : congestive heart failure, hypertension, age (>75 years), diabetes, stroke CI : confidence interval CO : cardiac output CoA : coarction of the aorta CT : computed tomography CVD : cardiovascular disease DBP : diastolic blood pressure DCM : dilated cardiomyopathy DVT : deep venous thrombosis ECG : electrocardiogram EF : ejection fraction ESC : European Society of Cardiology ESH : European Society of Hypertension ESICM : European Society of Intensive Care Medicine FDA : Food and Drug Administration HCM : hypertrophic cardiomyopathy ICD : implantable cardioverter-defibrillator INR : international normalized ratio i.v. : intravenous LMWH : low molecular weight heparin LV : left ventricular LVEF : left ventricular ejection fraction LVOTO : left ventricular outflow tract obstruction MRI : magnetic resonance imaging MS : mitral stenosis NT-proBNP : N-terminal pro B-type natriuretic peptide NYHA : New York Heart Association OAC : oral anticoagulant PAH : pulmonary arterial hypertension PAP : pulmonary artery pressure PCI : percutaneous coronary intervention PPCM : peripartum cardiomyopathy PS : pulmonary valve stenosis RV : right ventricular SBP : systolic blood pressure SVT : supraventricular tachycardia TGA : complete transposition of the great arteries TR : tricuspid regurgitation UFH : unfractionated heparin VSD : ventricular septal defect VT : ventricular tachycardia VTE : venous thrombo-embolism WHO : World Health Organization Guidelines summarize and evaluate all available evidence, at the time of the writing process, on a particular issue with the aim of assisting physicians in selecting the best management strategies for an individual patient, with a given condition, taking into account the impact on outcome, as well as the risk–benefit ratio of particular diagnostic or therapeutic means. Guidelines are no substitutes but are complements for textbooks and cover the European Society of Cardiology (ESC) Core Curriculum topics. Guidelines and recommendations should help the …
- Published
- 2011
10. Pregnancy outcome in women with repaired versus unrepaired isolated ventricular septal defect
- Author
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Yap, Sing, Drenthen, W, Pieper, PG, Moons, P, Mulder, BJM, Vliegen, HW, van Dijk, APJ, Meijboom, FJ (Folkert), Jaddoe, Vincent, Steegers, Eric, Boersma, Eric, Roos - Hesselink, Jolien, Cardiology, Erasmus MC other, and Obstetrics & Gynecology
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities - Abstract
Objective To compare the risks of pregnancy complications in women with repaired and unrepaired isolated ventricular septal defect (VSD). Design A retrospective multicentre study. Setting Tertiary centres in the Netherlands and Belgium. Methods Women were identified using two congenital heart disease registries. Eighty-eight women were identified who had experienced 202 pregnancies, including 46 miscarriages and nine terminations of pregnancy. Information on each completed pregnancy (n = 147; unrepaired VSD, n = 104; repaired VSD, n = 43) was obtained using medical records and telephone interviews. Data from the Generation R database (prospective cohort study; n = 9667) were used to determine the background risk (controls). Odds ratios and 95% CI were estimated using general estimation equation analysis adjusted for multiple pregnancies per woman, maternal age and parity status. Main outcome measures Adjusted odds ratios (AORs) for developing pregnancy complications in relation to corrective status. Results Pregnancies in women with an unrepaired VSD were associated with a higher risk of pre-eclampsia (AOR 4.59, 95% CI 2.01-10.5, P < 0.001) compared with controls. No differences were observed when comparing women with repaired VSD and controls. Pregnancies in women with repaired VSD were associated with a higher risk of premature labour (AOR 4.02, 95% CI 1.12-14.4, P = 0.03) and small-for-gestational-age (SGA) births (AOR 4.09, 95% CI 1.27-13.2, P = 0.02) compared with women with unrepaired VSD. Conclusions Women with unrepaired VSD are at increased risk of pre-eclampsia, which suggests that it is not a benign condition. In addition, women with repaired VSD are at increased risk of premature labour and SGA births compared with women with unrepaired VSD.
- Published
- 2010
11. Inheritance of congenital heart disease
- Author
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Roos - Hesselink, Jolien, Kerstjens-Frederikse, WS, Meijboom, FJ (Folkert), Pieper, PG, and Cardiology
- Published
- 2005
12. Aangeboren hartafwijking en zwangerschap
- Author
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Pieper, PG, Roos - Hesselink, Jolien, and Cardiology
- Published
- 2004
13. Successful pregnancy after an arterial switch procedure for complete transposition of the great arteries
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Ploeg, M, primary, Drenthen, W, additional, Van Dijk, A, additional, and Pieper, PG, additional
- Published
- 2006
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14. Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial.
- Author
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van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, and Mulder BJ
- Published
- 2013
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15. Implantable cardioverter defibrillator therapy in adults with congenital heart disease: who is at risk of shocks?
- Author
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Koyak Z, de Groot JR, Van Gelder IC, Bouma BJ, van Dessel PF, Budts W, van Erven L, van Dijk AP, Wilde AA, Pieper PG, Sieswerda GT, and Mulder BJ
- Published
- 2012
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16. Systematic review of pregnancy in women with inherited cardiomyopathies.
- Author
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Krul SP, van der Smagt JJ, van den Berg MP, Sollie KM, Pieper PG, and van Spaendonck-Zwarts KY
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- 2011
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17. Gender and outcome in adult congenital heart disease.
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Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Vliegen HW, van Dijk AP, Bouma BJ, Grobbee DE, and Mulder BJ
- Published
- 2008
18. Off-pump connection of the hepatic to the azygos vein through a lateral thoracotomy for relief of arterio-venous fistulas after a Kawashima procedure.
- Author
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Lopez FE, van den Heuvel F, Pieper PG, Waterbolk TW, and Ebels T
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- 2008
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19. Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)
- Author
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Authors, Task Force Members, Vahanian, Alec, Alfieri, Ottavio, Andreotti, Felicita, Antunes, Manuel J, Barón-Esquivias, Gonzalo, Baumgartner, Helmut, Borger, Michael Andrew, Carrel, Thierry P, De Bonis, Michele, Evangelista, Arturo, Falk, Volkmar, Lung, Bernard, Lancellotti, Patrizio, Pierard, Luc, Price, Susanna, Schäfers, Hans-Joachim, Schuler, Gerhard, Stepinska, Janina, Swedberg, Karl, Takkenberg, Johanna, Von Oppell, Ulrich Otto, Windecker, Stephan, Zamorano, Jose Luis, Zembala, Marian, ESC Committee for Practice Guidelines, CPG, Bax, Jeroen J, Ceconi, Claudio, Dean, Veronica, Deaton, Christi, Fagard, Robert, Funck-Brentano, Christian, Hasdai, David, Hoes, Arno, Kirchhof, Paulus, Knuuti, Juhani, Kolh, Philippe, McDonagh, Theresa, Moulin, Cyril, Popescu, Bogdan A, Reiner, Zeljko, Sechtem, Udo, Sirnes, Per Anton, Tendera, Michal, Torbicki, Adam, Document, Reviewers, Von Segesser, Ludwig, Badano, Luigi P, Bunc, Matjaz, Claeys, Marc J, Drinkovic, Niksa, Filippatos, Gerasimos, Habib, Gilbert, Kappetein, A Pieter, Kassab, Roland, Lip, Gregory Y H, Moat, Neil, Nickenig, Georg, Otto, Catherine M, Pepper, John, Piazza, Nicolo, Pieper, Petronella G, Rosenhek, Raphael, Shuka, Naltin, Schwammenthal, Ehud, Schwitter, Juerg, Mas, Pilar Tornos, Trindade, Pedro T, Walther, Thomas, Authors/Task Force, Member, Vahanian, A, Alfieri, Ottavio, Andreotti, F, Antunes, Mj, Baron Esquivias, G, Baumgartner, H, Borger, Ma, Carrel, Tp, DE BONIS, Michele, Evangelista, A, Falk, V, Iung, B, Lancellotti, P, Pierard, L, Price, S, Schafers, Hj, Schuler, G, Stepinska, J, Swedberg, K, Takkenberg, J, Von Oppell, Uo, Windecker, S, Zamorano, Jl, Zembala, M, ESC Committee for Practice, Guideline, Bax, Jj, Ceconi, C, Dean, V, Deaton, C, Fagard, R, Funck Brentano, C, Hasdai, D, Hoes, A, Kirchhof, P, Knuuti, J, Kolh, P, Mcdonagh, T, Moulin, C, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Tendera, M, Torbicki, A, Document, Reviewer, Von Segesser, L, Badano, Lp, Bunc, M, Claeys, Mj, Drinkovic, N, Filippatos, G, Habib, G, Kappetein, Ap, Kassab, R, Lip, Gy, Moat, N, Nickenig, G, Otto, Cm, Pepper, J, Piazza, N, Pieper, Pg, Rosenhek, R, Shuka, N, Schwammenthal, E, Schwitter, J, Mas, Pt, Trindade, Pt, and Walther, T.
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610 Medicine & health - Published
- 2012
20. Cardiovascular determinants of impaired placental function in women with cardiac dysfunction.
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Siegmund AS, Pieper PG, Bilardo CM, Gordijn SJ, Khong TY, Gyselaers W, van Veldhuisen DJ, and Dickinson MG
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- Female, Humans, Infant, Newborn, Lung, Pregnancy, Uterine Artery physiology, Vascular Remodeling, Heart Diseases, Placenta blood supply, Placenta physiology
- Abstract
Female heart disease has for a long time been an underrecognized problem in the field of cardiology. With an ever-growing number of these patients getting pregnant, cardiac dysfunction during pregnancy is an increasingly large medical problem. Previous work has shown that maternal heart disease may have an adverse effect on pregnancy outcome in both mother and child. The placenta forms the connection and it is postulated that cardiac dysfunction negatively affects the placenta, and consequently, neonatal outcome. Given the paucity of data in this field, more research on the influence of cardiac (mal)function on placental (mal)function is needed. The present review describes placental function in women with various types of cardiac dysfunction, thereby aiming to provide more insight into possible underlying mechanisms of placental malfunction. Organ dysfunction in patients with heart failure is for an important part based on reduced perfusion and venous congestion. This has been shown in other organs such as kidneys, liver and brain. In pregnant women with cardiac dysfunction, placental dysfunction may follow similar patterns. Moreover, other factors, such as pre-existing hypertension and chronic hypoxia may lead to further impairment of placental function, through abnormal vascular remodeling of the uterine spiral arteries. The pathophysiology of placental dysfunction in pregnant women with cardiac dysfunction may thus be multifactorial. It is therefore important to monitor closely cardiac and placental function in such high-risk pregnancies. Gaining a better understanding of the underlying pathophysiological mechanisms may have important clinical implications in terms of pregnancy counseling, monitoring and outcome., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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21. Bleeding and thrombotic risk in pregnant women with Fontan physiology.
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Girnius A, Zentner D, Valente AM, Pieper PG, Economy KE, Ladouceur M, Roos-Hesselink JW, Warshak C, Partington SL, Gao Z, Ollberding N, Faust M, Girnius S, Kaemmerer H, Nagdyman N, Cohen S, Canobbio M, Akagi T, Grewal J, Bradley E, Buber Y, Palumbo J, Walker N, Aboulhosn J, Oechslin E, Baumgartner H, Kurdi W, Book WM, Mulder BJM, and Veldtman GR
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- Adult, Chemoprevention methods, Chemoprevention statistics & numerical data, Drug Monitoring methods, Female, Humans, International Cooperation, Pregnancy, Fibrinolytic Agents administration & dosage, Fibrinolytic Agents adverse effects, Fibrinolytic Agents classification, Fontan Procedure adverse effects, Hemorrhage chemically induced, Hemorrhage epidemiology, Hemorrhage prevention & control, Hemorrhage therapy, Pregnancy Complications, Cardiovascular blood, Pregnancy Complications, Cardiovascular epidemiology, Pregnancy Complications, Cardiovascular etiology, Pregnancy Complications, Cardiovascular therapy, Pregnancy Complications, Hematologic epidemiology, Pregnancy Complications, Hematologic etiology, Pregnancy Complications, Hematologic physiopathology, Pregnancy Complications, Hematologic therapy, Risk Adjustment methods, Thrombophilia drug therapy, Thrombophilia etiology, Thrombosis epidemiology, Thrombosis etiology, Thrombosis therapy
- Abstract
Background/objectives: Pregnancy may potentiate the inherent hypercoagulability of the Fontan circulation, thereby amplifying adverse events. This study sought to evaluate thrombosis and bleeding risk in pregnant women with a Fontan., Methods: We performed a retrospective observational cohort study across 13 international centres and recorded data on thrombotic and bleeding events, antithrombotic therapies and pre-pregnancy thrombotic risk factors., Results: We analysed 84 women with Fontan physiology undergoing 108 pregnancies, average gestation 33±5 weeks. The most common antithrombotic therapy in pregnancy was aspirin (ASA, 47 pregnancies (43.5%)). Heparin (unfractionated (UFH) or low molecular weight (LMWH)) was prescribed in 32 pregnancies (30%) and vitamin K antagonist (VKA) in 10 pregnancies (9%). Three pregnancies were complicated by thrombotic events (2.8%). Thirty-eight pregnancies (35%) were complicated by bleeding, of which 5 (13%) were severe. Most bleeds were obstetric, occurring antepartum (45%) and postpartum (42%). The use of therapeutic heparin (OR 15.6, 95% CI 1.88 to 129, p=0.006), VKA (OR 11.7, 95% CI 1.06 to 130, p=0.032) or any combination of anticoagulation medication (OR 13.0, 95% CI 1.13 to 150, p=0.032) were significantly associated with bleeding events, while ASA (OR 5.41, 95% CI 0.73 to 40.4, p=0.067) and prophylactic heparin were not (OR 4.68, 95% CI 0.488 to 44.9, p=0.096)., Conclusions: Current antithrombotic strategies appear effective at attenuating thrombotic risk in pregnant women with a Fontan. However, this comes with high (>30%) bleeding risk, of which 13% are life threatening. Achieving haemostatic balance is challenging in pregnant women with a Fontan, necessitating individualised risk-adjusted counselling and therapeutic approaches that are monitored during the course of pregnancy., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2021
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22. Early N-terminal pro-B-type natriuretic peptide is associated with cardiac complications and function during pregnancy in congenital heart disease.
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Siegmund AS, Pieper PG, Bouma BJ, Rosenberg FM, Groen H, Bilardo CM, van Veldhuisen DJ, and Dickinson MG
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Background: Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at 20 weeks' gestation predict adverse cardiovascular (CV) complications during pregnancy in women with congenital heart disease (CHD). To improve early risk assessment in these women, we investigated the predictive value of first-trimester NT-proBNP for CV complications and its association with ventricular function during pregnancy., Methods: Pregnant women with CHD, previously enrolled in a prospective national study or evaluated by an identical protocol, were included. Clinical data, echocardiographic evaluation and NT-proBNP measurements were obtained at 12, 20 and 32 weeks' gestation. Elevated NT-proBNP was defined as > 235 pg/ml (95th percentile reference value of healthy pregnant women in the literature)., Results: We examined 126 females (mean age 29 years). Elevated NT-proBNP at 12 weeks was associated with CV complications (n = 7, 5.6%, odds ratio 10.9, p = 0.004). Arrhythmias were the most common complication (71%). The negative predictive value of low NT-proBNP to exclude CV complications was 97.2%. In women with CV complications, NT-proBNP levels remained high throughout pregnancy, while a decrease was seen in women without CV complications (p < 0.001 for interaction between group and time). At 12 weeks, higher NT-proBNP levels were associated with impaired subpulmonary ventricular function (p < 0.001) and also with a decline in subpulmonary ventricular function later in pregnancy (p = 0.012)., Conclusions: In this study, first-trimester NT-proBNP levels were associated with adverse CV complications and a decline in subpulmonary ventricular function later in pregnancy in women with CHD. Early NT-proBNP evaluation is useful for tailored care in pregnant women with CHD.
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- 2021
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23. Reduced right ventricular function on cardiovascular magnetic resonance imaging is associated with uteroplacental impairment in tetralogy of Fallot.
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Siegmund AS, Willems TP, Pieper PG, Bilardo CM, Gorter TM, Bouma BJ, Jongbloed MRM, Sieswerda GT, Roos-Hesselink JW, van Dijk APJ, van Veldhuisen DJ, and Dickinson MG
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- Adult, Blood Flow Velocity, Female, Humans, Predictive Value of Tests, Pregnancy, Prenatal Diagnosis, Retrospective Studies, Risk Factors, Tetralogy of Fallot complications, Tetralogy of Fallot diagnostic imaging, Tetralogy of Fallot physiopathology, Ultrasonography, Doppler, Umbilical Arteries diagnostic imaging, Uterine Artery diagnostic imaging, Ventricular Dysfunction, Right etiology, Ventricular Dysfunction, Right physiopathology, Cardiac Surgical Procedures adverse effects, Magnetic Resonance Imaging, Cine, Placental Circulation, Tetralogy of Fallot surgery, Umbilical Arteries physiopathology, Uterine Artery physiopathology, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Function, Right
- Abstract
Background: Maternal right ventricular (RV) dysfunction (measured by echocardiography) is associated with impaired uteroplacental circulation, however echocardiography has important limitations in the assessment of RV function. We therefore aimed to investigate the association of pre-pregnancy RV and left ventricular (LV) function measured by cardiovascular magnetic resonance with uteroplacental Doppler flow parameters in pregnant women with repaired Tetralogy of Fallot (ToF)., Methods: Women with repaired ToF were examined, who had been enrolled in a prospective multicenter study of pregnant women with congenital heart disease. Clinical data and CMR evaluation before pregnancy were compared with uteroplacental Doppler parameters at 20 and 32 weeks gestation. In particular, pulsatility index (PI) of uterine and umbilical artery were studied., Results: We studied 31 women; mean age 30 years, operated at early age. Univariable analyses showed that reduced RV ejection fraction (RVEF; P = 0.037 and P = 0.001), higher RV end-systolic volume (P = 0.004) and higher LV end-diastolic and end-systolic volume (P = 0.001 and P = 0.003, respectively) were associated with higher uterine or umbilical artery PI. With multivariable analyses (corrected for maternal age and body mass index), reduced RVEF before pregnancy remained associated with higher umbilical artery PI at 32 weeks (P = 0.002). RVEF was lower in women with high PI compared to women with normal PI during pregnancy (44% vs. 53%, p = 0.022). LV ejection fraction was not associated with uterine or umbilical artery PI., Conclusions: Reduced RV function before pregnancy is associated with abnormal uteroplacental Doppler flow parameters. It could be postulated that reduced RV function on pre-pregnancy CMR (≤2 years) is a predisposing factor for impaired placental function in women with repaired ToF.
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- 2020
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24. Doppler gradients, valve area and ventricular function in pregnant women with aortic or pulmonary valve disease: Left versus right.
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Siegmund AS, Pieper PG, Mulder BJM, Sieswerda GT, van Dijk APJ, Roos-Hesselink JW, Jongbloed MRM, Konings TC, Bouma BJ, Groen H, Sollie-Szarynska KM, Kampman MAM, Bilardo CM, van Veldhuisen DJ, and Aalberts JJJ
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- Aortic Valve, Female, Humans, Pregnancy, Pregnant Women, Prospective Studies, Stroke Volume, Ventricular Function, Left, Aortic Valve Stenosis, Heart Valve Diseases diagnostic imaging, Heart Valve Diseases epidemiology, Pulmonary Valve diagnostic imaging
- Abstract
Objective: Little is known about the course of echocardiographic parameters used for the evaluation of valvular heart disease (VHD) during pregnancy, hampering interpretation of possible changes (physiological vs. pathophysiological). Therefore we studied the course of these parameters and ventricular function in pregnant women with aortic and pulmonary VHD., Methods: The cohort comprised 66 pregnant women enrolled in the prospective ZAHARA studies or evaluated by an identical protocol who had pulmonary VHD or aortic VHD (stenosis/prosthetic valve). The control group comprised 46 healthy pregnant women. Echocardiography was performed preconception, during pregnancy and 1 year postpartum. Peak gradient, mean gradient, aortic valve area (AVA)/effective orifice area (EOA), left ventricular ejection fraction (LVEF) and right ventricular function (RVF; TAPSE) were assessed., Results: Peak and mean gradients increased during pregnancy compared to preconception in women with aortic VHD and controls (p < 0.0125), but not in women with pulmonary VHD. AVA/EOA remained unchanged. Preconception and postpartum gradients were comparable in all groups. Mean LVEF was normal in pregnant women with VHD and controls. Mean TAPSE was lower (p < 0.001) in women with pulmonary VHD compared to women with aortic VHD and controls (<20 mm vs. ≥23 mm; p < 0.001). In women with pulmonary VHD a decrease of TAPSE was observed during pregnancy (p = 0.005)., Conclusion: Physiological changes during pregnancy lead to increased Doppler gradients in women with aortic VHD. This increase was not found in women with pulmonary VHD, probably caused by impaired RVF. Therefore, evaluation of RVF during pregnancy might be important to prevent underestimation of the degree of stenosis., Competing Interests: Declaration of competing interest The authors report no relationships that could be construed as a conflict of interest., (Copyright © 2019 Elsevier B.V. All rights reserved.)
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- 2020
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25. Maternal mortality due to cardiovascular disease in the Netherlands: a 21-year experience.
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Lameijer H, Schutte JM, Schuitemaker NWE, van Roosmalen JJM, and Pieper PG
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Objective: Cardiovascular disorders are the leading cause of indirect maternal mortality in Europe. The aim of this study is to present an extensive overview concerning the specific cardiovascular causes of maternal death and to identify avoidable contributing care factors related to these deaths., Methods: We assessed all cases of maternal death due to cardiovascular disorders collected by a systematic national confidential enquiry of maternal deaths published by the Dutch Maternal Mortality and Morbidity Committee on behalf of the Netherlands Society of Obstetrics and Gynaecology over a 21-year period (1993-2013) in the Netherlands., Results: There were 96 maternal cardiovascular deaths (maternal mortality rate due to cardiovascular diseases 2.4/100,000 liveborn children). Causes were aortic dissection (n = 20, 21%), ischaemic heart disease (n = 17, 18%), cardiomyopathies (including peripartum cardiomyopathy and myocarditis, n = 20, 21%) and (unexplained) sudden death (n = 27, 28%). Fifty-five percent of the deaths occurred postpartum (n = 55, 55%). Care factors that may have contributed to the adverse outcome were identified in 27 cases (28%). These factors were patient-related in 40% (pregnancy against medical advice, underestimation of symptoms) and healthcare-provider-related in 60% (symptoms not recognised, delay in diagnosis, delay in referral)., Conclusion: The maternal cardiovascular mortality ratio is low in the Netherlands and the main causes of maternal cardiovascular mortality are in line with other European reports. In a minority of cases, care factors that were possibly preventable were identified. Women with cardiovascular disease should be properly counselled about the risks of pregnancy and the symptoms of complications. Education of care providers regarding the incidence, presentation and diagnosis of cardiovascular disease during pregnancy is recommended.
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- 2020
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26. Quality of Life Among Patients With Congenital Heart Disease After Valve Replacement.
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Pragt H, Pieper PG, van Slooten YJ, Freling HG, van Dijk APJ, Sieswerda GTJ, Bouma BJ, Post MC, Jongbloed MRM, Willems TP, Ebels T, and van Melle JP
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- Adult, Aged, Cross-Sectional Studies, Exercise Tolerance, Female, Health Status, Heart Defects, Congenital diagnosis, Heart Defects, Congenital physiopathology, Heart Defects, Congenital psychology, Heart Valves physiopathology, Hemodynamics, Humans, Life Expectancy, Male, Middle Aged, Netherlands, Recovery of Function, Retrospective Studies, Risk Factors, Social Behavior, Treatment Outcome, Ventricular Function, Young Adult, Heart Defects, Congenital surgery, Heart Valve Prosthesis Implantation adverse effects, Heart Valves surgery, Quality of Life
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Most studies concerning valve replacement in congenital heart disease (CHD) focus on surgical morbidity and mortality. However, with the increased life expectancy of these patients, the focus shifts to quality of life (QOL). The aim of this study was to report and compare the QOL of CHD patients after valve replacement with the general population and to find factors associated with QOL. In a multicenter cross-sectional observational study of adults with CHD, QOL was measured with the RAND-36 questionnaire (a health-related QOL questionnaire, with 8 domains scoring from 0 to 100; higher scores indicate a better QOL). Functional status was measured with exercise capacity testing. Uni- and multivariable linear regression was used to find associations with QOL. In total, 324 patients with CHD and a prosthetic valve were included in this study. CHD patients with a valve replacement scored significantly lower than the general population on the general health, vitality, and social functioning domains (P < 0.05). On the bodily pain domain, they scored significantly higher (less pain) (P < 0.001). Higher NYHA class was associated with a lower QOL for all domains, reflecting the importance of functional capacity. Other variables related to aspects of QOL were age, gender, exercise capacity, and employment status. Adult patients with CHD and a prosthetic valve have lower scores on the QOL domains general health, vitality, and social functioning as compared to the general population. NYHA class was negatively associated with all QOL domains. Health care professionals should be aware of these patterns in counseling patients., (Copyright © 2019 Elsevier Inc. All rights reserved.)
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- 2019
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27. Maternal right ventricular function, uteroplacental circulation in first trimester and pregnancy outcome in women with congenital heart disease.
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Siegmund AS, Kampman MAM, Oudijk MA, Mulder BJM, Sieswerda GTJ, Koenen SV, Hummel YM, de Laat MWM, Sollie-Szarynska KM, Groen H, van Dijk APJ, van Veldhuisen DJ, Bilardo CM, and Pieper PG
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- Adult, Female, Humans, Pregnancy, Pregnancy Outcome, Prospective Studies, Pulsatile Flow physiology, Uterine Artery physiology, Vascular Resistance physiology, Heart Defects, Congenital physiopathology, Placental Circulation physiology, Pregnancy Complications, Cardiovascular physiopathology, Pregnancy Trimester, First, Pregnant Women, Ventricular Function, Right
- Abstract
Objective: Pregnant women with congenital heart disease (CHD) have an increased risk of abnormal uteroplacental flow, measured from the second trimester onwards, which is associated with pregnancy complications affecting the mother and the fetus. Maternal right ventricular (RV) dysfunction has been suggested as a predisposing factor for impaired uteroplacental flow in these women. The aim of this study was to investigate the association of first-trimester uteroplacental flow measurements with prepregnancy maternal cardiac function and pregnancy complications in women with CHD, with particular focus on the potential role of RV (dys)function., Methods: This study included 138 pregnant women with CHD from the prospective ZAHARA III study (Zwangerschap bij Aangeboren HARtAfwijkingen; Pregnancy and CHD). Prepregnancy clinical and echocardiographic data were collected. Clinical evaluation, echocardiography (focused on RV function, as assessed by tricuspid annular plane systolic excursion (TAPSE)) and uterine artery (UtA) pulsatility index (PI) measurements were performed at 12, 20 and 32 weeks of gestation. Univariable and multivariable regression analyses were performed to assess the association between prepregnancy variables and UtA-PI during pregnancy. The association between UtA-PI at 12 weeks and cardiovascular, obstetric and neonatal complications was also assessed., Results: On multivariable regression analysis, prepregnancy TAPSE was associated negatively with UtA-PI at 12 weeks of gestation (β = -0.026; P = 0.036). Women with lower prepregnancy TAPSE (≤ 20 mm vs > 20 mm) had higher UtA-PI at 12 weeks (1.5 ± 0.5 vs 1.2 ± 0.6; P = 0.047). Increased UtA-PI at 12 weeks was associated with obstetric complications (P = 0.003), particularly hypertensive disorders (pregnancy-induced hypertension and pre-eclampsia, P = 0.019 and P = 0.026, respectively)., Conclusions: In women with CHD, RV dysfunction before pregnancy seems to impact placentation, resulting in increased resistance in UtA flow, which is detectable as early as in the first trimester. This, in turn, is associated with pregnancy complications. Early monitoring of uteroplacental flow might be of value in women with CHD with pre-existing subclinical RV dysfunction to identify pregnancies that would benefit from close obstetric surveillance. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd., (Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.)
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- 2019
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28. Pregnancy in women with pre-existent ischaemic heart disease: a systematic review with individualised patient data.
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Lameijer H, Burchill LJ, Baris L, Ruys TP, Roos-Hesselink JW, Mulder BJM, Silversides CK, van Veldhuisen DJ, and Pieper PG
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- Adult, Female, Humans, Live Birth, Myocardial Ischemia mortality, Myocardial Ischemia physiopathology, Myocardial Ischemia therapy, Pregnancy, Pregnancy Complications mortality, Pregnancy Complications physiopathology, Pregnancy Complications therapy, Risk Assessment, Risk Factors, Treatment Outcome, Myocardial Ischemia epidemiology, Pregnancy Complications epidemiology
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Introduction: Studies on pregnancy risk in women with ischaemic heart disease (IHD) have mainly excluded pregnancies in women with pre-existent IHD. There is a need for better information about the pregnancy risks in these women and their offspring., Methods: We performed a systematic review searching the PubMed/MEDLINE public database for pregnancy in women with pre-existent IHD analysing the cardiac, obstetric and fetal/neonatal outcome of pregnancy in women with pre-existing IHD. Individual patient data were requested from large series. The primary outcome endpoints was a composite of ischaemic complications including maternal death, acute coronary syndrome and ventricular tachycardia., Results: 116 women with pre-existent IHD had 124 pregnancies including one twin pregnancy. They had a 21% chance of having an uncomplicated pregnancy (completed pregnancy without cardiovascular, obstetric or fetal/neonatal complications, n=26). Primary (ischaemic) endpoints occurred in 9% (n=11). Women with atherosclerosis had more cardiovascular complications compared with pregnancies in women with other underlying pathology for IHD (50%vs23%, P=0.02) but no significant difference in occurrence of primary endpoints (13% vs 9%, P=0.53). There were two maternal cardiac deaths (2%), one of which occurred in the 18th week of pregnancy and the other postpartum. Obstetric complications occurred in 58% (n=65) of pregnancies and fetal/neonatal complications in 42% (n=47)., Conclusion: Pregnancies in women with pre-existing IHD are high-risk pregnancies. These women have a high risk of ischaemic cardiovascular complications including 2% maternal mortality. The risk of ischaemic complications is especially high among women with atherosclerotic coronary artery disease., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2019
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29. Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicenter randomized controlled trial.
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van Dissel AC, Winter MM, van der Bom T, Vliegen HW, van Dijk APJ, Pieper PG, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJM, and Bouma BJ
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- Adult, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Time Factors, Treatment Outcome, Ventricular Dysfunction, Right diagnosis, Young Adult, Antihypertensive Agents administration & dosage, Valsartan administration & dosage, Ventricular Dysfunction, Right drug therapy, Ventricular Dysfunction, Right mortality
- Abstract
Objectives: In the VAL-SERVE (Valsartan in Systemic Right Ventricle) trial, three-year valsartan treatment improved systemic ventricular function only in symptomatic patients with congenitally or with an atrial switch corrected transposition of the great arteries. The aim of the current study was to investigate the longer-term clinical outcomes after valsartan treatment., Methods: From 2006 to 2009, 88 adults were randomly allocated 1:1 to either valsartan or placebo for three consecutive years. Endpoints were defined as overall survival and freedom from clinical events (arrhythmia, heart failure, tricuspid valve surgery, death)., Results: Cardiac drug use and median follow-up after trial close-out (8.3 years) was similar between the randomization groups. Six patients (valsartan n = 3, placebo n = 3) died in 364 and 365 person-years (P = 0.999). No difference in the composite or separate clinical endpoints was found between the randomization groups, with corresponding long-term event-free survival rates of 50% and 34%. Nevertheless, in symptomatic patients valsartan significantly reduced the risk for events compared to placebo (HR 0.37, 95% CI 0.17-0.92). Analysis for repeated events and on-treatment analysis with any renin-angiotensin-aldosterone-system-inhibitor did not alter these results., Conclusions: Valsartan treatment in systemic RV patients did not result in improved survival at longer-term follow-up, but was associated with decreased risk of events in symptomatic patients., (Copyright © 2018. Published by Elsevier B.V.)
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- 2019
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30. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy.
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Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomstrom-Lundqvist C, Cifkova R, De Bonis M, Iung B, Johnson MR, Kintscher U, Kranke P, Lang IM, Morais J, Pieper PG, Presbitero P, Price S, Rosano GMC, Seeland U, Simoncini T, Swan L, and Warnes CA
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- Advisory Committees standards, Cardiovascular Agents therapeutic use, Counseling methods, Europe, Female, Humans, Poland, Pregnancy, Societies, Medical standards, Cardiology standards, Practice Guidelines as Topic, Pregnancy Complications, Cardiovascular diagnosis, Pregnancy Complications, Cardiovascular therapy, Prenatal Diagnosis methods
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- 2019
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31. Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease.
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Lameijer H, van Slooten YJ, Jongbloed MRM, Oudijk MA, Kampman MAM, van Dijk AP, Post MC, Mulder BJ, Sollie KM, van Veldhuisen DJ, Ebels T, van Melle JP, and Pieper PG
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- Adult, Bioprosthesis trends, Cohort Studies, Female, Heart Defects, Congenital epidemiology, Heart Valve Diseases epidemiology, Heart Valve Prosthesis trends, Humans, Netherlands epidemiology, Postoperative Complications epidemiology, Pregnancy, Pregnancy Complications, Cardiovascular epidemiology, Pregnancy Outcome epidemiology, Retrospective Studies, Young Adult, Bioprosthesis adverse effects, Heart Defects, Congenital surgery, Heart Valve Diseases surgery, Heart Valve Prosthesis adverse effects, Postoperative Complications etiology, Pregnancy Complications, Cardiovascular surgery
- Abstract
Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease., Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV., Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) ≥20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19, ≤20 weeks) occurred more frequently in women using anticoagulation (P < .05). During 42% of pregnancies of women with mechanical PHV a combined low molecular weight heparin (LMWH) vitamin-K-antagonist anticoagulation regime was used (n = 8). Overall, cardiovascular, obstetric and fetal/neonatal complications occurred in 17% (n = 13), 68% (n = 42) and 42% (n = 27) of the pregnancies. Women with mechanical PHV had significantly higher cardiovascular (12% vs 32%, P < .05), obstetric (59% vs 85%, P = .02) and fetal/neonatal (34% vs 61%, P < .05) complication rates than women with biological PHV. This was related to PHV thrombosis (n = 3, P < .02), post-partum hemorrhage (P < .02), cesarean section (P < .02), low birth weight and small for gestational age (both P < .05). PHV thrombosis occurred in 3 pregnancies, including 2/5 pregnancies with pulmonary mechanical PHV. PHV thrombosis was related to necessary cessation of anticoagulation therapy or insufficient monitoring of LMWH. Other cardiovascular complications occurred equally frequent in both groups., Conclusion: Complications occur more often in pregnancies of women with a mechanical PHV than in women with a biological PHV, mainly caused by PHV thrombosis and bleeding complications. Meticulous monitoring of anticoagulation in pregnant women is necessary. Women with a pulmonary mechanical PHV are at high risk of complications., (Copyright © 2018. Published by Elsevier B.V.)
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- 2018
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32. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy.
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Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist C, Cífková R, De Bonis M, Iung B, Johnson MR, Kintscher U, Kranke P, Lang IM, Morais J, Pieper PG, Presbitero P, Price S, Rosano GMC, Seeland U, Simoncini T, Swan L, and Warnes CA
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- 2018
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33. Efficacy and safety of direct oral anticoagulants during pregnancy; a systematic literature review.
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Lameijer H, Aalberts JJJ, van Veldhuisen DJ, Meijer K, and Pieper PG
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- Administration, Oral, Anticoagulants administration & dosage, Anticoagulants adverse effects, Female, Humans, Pregnancy, Pregnancy Complications, Cardiovascular prevention & control, Pregnancy Outcome, Rivaroxaban administration & dosage, Rivaroxaban adverse effects, Venous Thromboembolism prevention & control, Anticoagulants therapeutic use, Pregnancy Complications, Cardiovascular drug therapy, Rivaroxaban therapeutic use, Venous Thromboembolism drug therapy
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Introduction: Direct oral anticoagulants (DOACs) are increasingly used for anticoagulation or prevention of thromboembolic events in conditions that may co-occur with pregnancy. However, evidence regarding efficacy and safety during pregnancy is scarce., Aim: To review the current literature concerning the efficacy, safety and outcome of DOACs during pregnancy in humans., Methods: We systematically searched the MedLine public database for all studies describing the use of DOACs during pregnancy published up to July 4th 2017., Results: 236 cases of DOAC use during pregnancy were reported. Rivaroxaban was the most reported DOAC (n = 178). DOACs were mostly used for prophylaxis or treatment of venous thromboembolism (n = 91). DOACs were discontinued within the first 2 months of pregnancy in 84%, maximum reported duration of use was 26 weeks. Pregnancy outcome data were available for 140 pregnancies. Thirty-nine pregnancies were electively terminated. In the remaining 101 pregnancies total miscarriage rate was 31% (n = 31) and live birth rate was 68% (n = 69, 1 missing). Foetal and neonatal abnormalities were reported in 8 pregnancies, of which at least half were suspected to be related to rivaroxaban use during the 1st trimester of pregnancy. In only 18% of cases (n = 42), the presence or absence of thrombotic and bleeding complications was reported., Conclusion: The limited available evidence raises concern regarding embryo-foetal safety, with high incidence of miscarriages and a 4% rate of anomalies with the use of rivaroxaban. Not enough data are available to judge safety and efficacy of the use of DOACs during pregnancy.
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- 2018
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34. Cardiovascular biochemical risk factors among women with spontaneous preterm delivery.
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Heida KY, Kampman MA, Franx A, De Laat MW, Mulder BJ, Van der Post JA, Bilardo CM, Pieper PG, Sollie KM, Sieswerda GT, Ris-Stalpers C, and Oudijk MA
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- Adult, Body Mass Index, Female, Gestational Age, Humans, Infant, Newborn, Netherlands, Pregnancy, Prospective Studies, Risk Factors, Term Birth, Triglycerides blood, Young Adult, Cardiovascular Diseases epidemiology, Premature Birth epidemiology
- Abstract
Objective: To determine whether women delivering preterm have unfavorable cardiovascular profiles as compared with women who deliver at term., Methods: A prospective observational cohort study enrolled 165 women with spontaneous preterm delivery (sPTD) at 24
+0 and 36+6 gestational weeks in three perinatal care centers in The Netherlands between August 2012 and August 2014. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, apolipoprotein, glucose, and homocysteine were measured within 24 hours after delivery. Lipids and cardiovascular biochemical risk factors were compared between women with sPTD and an external comparison group of 30 women with term delivery via analysis of covariance., Results: Mean gestational age at delivery was 30.7 ± 3.6 weeks in the sPTD group and 40.3 ± 1.3 weeks in the reference group. Data were adjusted for body mass index, age, and center. As compared with the reference group, total cholesterol and LDL-cholesterol levels were lower and glucose levels were higher among women with sPTD., Conclusion: An association between sPTD and unfavorable lipids and cardiovascular biochemical risk factors was not established. The higher levels of glucose in the sPTD group might be due to increased insulin resistance, which is associated with a higher risk of sPTD., (© 2017 International Federation of Gynecology and Obstetrics.)- Published
- 2018
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35. Quality of life and sexual well-being in patients with a Fontan circulation: An explorative pilot study with a mixed method design.
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Wolff D, van de Wiel HBM, de Muinck Keizer ME, van Melle JP, Pieper PG, Berger RMF, Ebels T, and Weijmar Schultz WCM
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- Adolescent, Adult, Child, Cross-Sectional Studies, Female, Heart Defects, Congenital physiopathology, Heart Defects, Congenital surgery, Humans, Male, Middle Aged, Pilot Projects, Postoperative Period, Surveys and Questionnaires, Young Adult, Fontan Procedure, Health Status, Heart Defects, Congenital psychology, Quality of Life, Sexual Behavior psychology
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Objective: To get an impression of the quality of life (QOL) and sexual well-being in the Fontan population, and to generate hypotheses for future research., Methods: For this cross-sectional pilot study, questionnaires regarding health-related QOL, sexual function and fertility/pregnancy were completed by 21 patients with a Fontan circulation >16 years old, followed at the University Medical Center Groningen, the Netherlands. Semi-structured qualitative interviews were conducted in 8 patients., Results: Fontan patients scored significantly lower on general health than their healthy peers (t(19)=-3.0, P = .008), whereas their scores on other QOL domains and sexual well-being were comparable to normal values. During childhood, most patients experienced physical limitations and the feeling of being an outsider, and frequently faced bullying. Regarding sexual well-being, large interindividual differences were noted. Four interviewed patients (25-30 years) reported a good sexual well-being, whereas the other interviewed patients (33-47 years) reported erectile dysfunction, low self-esteem and avoidance of sexual intercourse. Both the QOL domains mental health and role restrictions due to emotional problems were associated with female avoidance (P = .083, respectively, P = .089) and dyspareunia (P = ns respectively P = .094). In males, role restrictions due to physical problems and health change were related to sexual dissatisfaction (P = .056) respectively nonsensuality (P = .025)., Conclusions: Overall, Fontan patients have a relatively preserved quality of life and sexual wellbeing but face more social isolation and bullying during childhood/adolescence than their healthy peers. Sexual problems were mainly associated with physical limitations in males and with psychosocial limitations in females. Finally, sexual dysfunction was more common in older Fontan patients, and future research has to clarify whether progressive attrition of the Fontan circulation affects the patients' QOL and sexual well-being., (© 2018 The Authors. Congenital Heart Disease published by Wiley Periodicals, Inc.)
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- 2018
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36. Pregnancy in women with corrected aortic coarctation: Uteroplacental Doppler flow and pregnancy outcome.
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Siegmund AS, Kampman MAM, Bilardo CM, Balci A, van Dijk APJ, Oudijk MA, Mulder BJM, Roos-Hesselink JW, Sieswerda GT, Koenen SV, Sollie-Szarynska KM, Ebels T, van Veldhuisen DJ, and Pieper PG
- Subjects
- Adult, Aortic Coarctation diagnostic imaging, Aortic Coarctation surgery, Cohort Studies, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Complications, Cardiovascular diagnostic imaging, Pregnancy Complications, Cardiovascular surgery, Prospective Studies, Retrospective Studies, Aortic Coarctation physiopathology, Laser-Doppler Flowmetry trends, Placental Circulation physiology, Pregnancy Complications, Cardiovascular physiopathology, Pregnancy Outcome
- Abstract
Objective: Women with repaired coarctation of the aorta (rCoA) are at risk of hypertensive disorders and other complications during pregnancy. Hypertensive disorders in pregnant women are associated with inadequate uteroplacental flow, which is related to adverse offspring outcome. The aim of this study was to investigate the relationship of maternal cardiac function, placental function and pregnancy complications in women with rCoA., Methods: We included 49 pregnant women with rCoA and 69 controls from the prospective ZAHARA-studies (Zwangerschap bij Aangeboren HARtAfwijkingen, pregnancy in congenital heart disease). Clinical evaluation, echocardiography and uteroplacental Doppler flow (UDF) measurements were performed at 20 and 32weeks gestation. Univariable regression analysis was performed., Results: Comparison of rCoA and healthy women. In women with rCoA, tricuspid annular plane systolic excursion (TAPSE) decreased during pregnancy (25.7mm to 22.8mm, P=0.006). UDF indices and pregnancy complication rates were similar in both groups. Offspring of rCoA women had lower birth weight (3233g versus 3578g, P=0.001), which was associated with β-blocker use during pregnancy (β=-418.0, P=0.01). Association of cardiac function and UDF. Right ventricular (RV) function before pregnancy (TAPSE) and at 20weeks gestation (TAPSE and RV fractional area change) were associated with impaired UDF indices (umbilical artery pulsatility index at 20weeks β=-0.02, P=0.01, resistance index at 20 and 32weeks β=-0.01, P=0.02 and β=-0.02, P=0.01 and uterine artery pulsatility and resistance index at 20weeks gestation β=-0.02, P=0.05 and β=-0.01, P=0.02)., Conclusions: Women with rCoA tolerate pregnancy well. However, RV function is altered and is associated with impaired placentation., (Copyright © 2017 Elsevier B.V. All rights reserved.)
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- 2017
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37. Diagnostic value of Doppler echocardiography for identifying hemodynamic significant pulmonary valve regurgitation in tetralogy of Fallot: comparison with cardiac MRI.
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Beurskens NEG, Gorter TM, Pieper PG, Hoendermis ES, Bartelds B, Ebels T, Berger RMF, Willems TP, and van Melle JP
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- Adolescent, Adult, Area Under Curve, Female, Humans, Male, Predictive Value of Tests, Pulmonary Valve physiopathology, Pulmonary Valve Insufficiency etiology, Pulmonary Valve Insufficiency physiopathology, ROC Curve, Reproducibility of Results, Retrospective Studies, Tetralogy of Fallot diagnostic imaging, Tetralogy of Fallot physiopathology, Tetralogy of Fallot surgery, Young Adult, Echocardiography, Doppler, Color, Echocardiography, Doppler, Pulsed, Hemodynamics, Magnetic Resonance Imaging, Cine, Pulmonary Valve diagnostic imaging, Pulmonary Valve Insufficiency diagnostic imaging, Tetralogy of Fallot complications
- Abstract
Quantification of pulmonary regurgitation (PR) is essential in the management of patients with repaired tetralogy of Fallot (TOF). We sought to evaluate the accuracy of first-line Doppler echocardiography in comparison with cardiac magnetic resonance imaging (MRI) to identify hemodynamic significant PR. Paired cardiac MRI and echocardiographic studies (n = 97) in patients with repaired TOF were retrospectively analyzed. Pressure half time (PHT) and pulmonary regurgitation index (PRi) were measured using continuous wave Doppler. The ratio of the color flow Doppler regurgitation jet width to pulmonary valve (PV) annulus (jet/annulus ratio) and diastolic to systolic time velocity integral (DSTVI; pulsed wave Doppler) were assessed. Accuracy of echocardiographic measurements was tested to identify significant PR as determined by phase-contrast MRI (PR fraction [PRF] ≥ 20%). Mean PRF was 29.4 ± 15.7%. PHT < 100 ms had a sensitivity of 93%, specificity 75%, positive predictive value (PPV) 92% and negative predictive value (NPV) 78% for identifying significant PR (C-statistic 0.82). PRi < 0.77 had sensitivity and specificity of 66% and 54%, respectively (C-statistic 0.63). Jet/annulus ratio ≥1/3 had sensitivity 96%, specificity 75%, PPV 92% and NPV 82% (C-statistic 0.87). DSTVI had sensitivity 84%, specificity 33%, PPV 84% and NPV 40%, (C-statistic 0.56). Combined jet/annulus ratio ≥1/3 and PHT < 100 ms was highly accurate in identifying PRF ≥ 20%, with sensitivity 97% and specificity 100%. PHT and jet/annulus ratio on Doppler echocardiography, especially when combined, are highly accurate in identifying significant PR and therefore seem useful in the follow-up of patients with repaired TOF.
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- 2017
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38. Mechanical valves in the pulmonary position: An international retrospective analysis.
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Pragt H, van Melle JP, Javadikasgari H, Seo DM, Stulak JM, Knez I, Hörer J, Muñoz-Guijosa C, Dehaki MG, Shin HJ, Dearani JA, Dehaki MG, Pieper PG, Eulenburg C, Dos L, and Ebels T
- Subjects
- Adolescent, Adult, Austria, Germany, Humans, Iran, Netherlands, Reoperation, Republic of Korea, Retrospective Studies, Spain, Treatment Outcome, Young Adult, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Pulmonary Valve surgery
- Abstract
Objective: Life expectancy of patients with congenital heart disease has improved over the past decades, increasing the need for a durable pulmonary prosthetic valve. Biological valves in various forms have become the valve of choice for pulmonary valve replacement (PVR), but structural valve deterioration is unavoidable in the long term. Use of a mechanical valve could be an alternative, but data on long-term outcomes are sparse., Methods: We retrospectively collected and analyzed data on 364 patients with mechanical valves implanted in the pulmonary position between 1965 and 2014. The data originate from medical centers in Barcelona (Spain), Graz (Austria), Groningen (the Netherlands), Munich (Germany), Rochester (United States), Seoul (Republic of Korea), and Tehran (Iran)., Results: Median follow-up duration was 4.26 years (range, 0-27 years), mean age at implantation was 27.16 ± 12.2 years. Tetralogy of Fallot was the most common primary cardiac diagnosis, with a subgroup of 69.8%. Freedom from valvular thrombosis was 91% (95% confidence interval [CI], 87%-94%) at 5 years and 86% (95% CI, 81%-91%) at 10 years post-PVR. With a success rate up to 88%, thrombolysis was a successful therapy. Freedom from reoperation was 97% (95% CI, 94%-99%) at 5 years post-PVR and 91% (95% CI, 85%-95%) at 10 years., Conclusions: Mechanical PVR is associated with a limited risk of valvular thrombosis. Thrombolysis was an effective treatment in the majority., (Copyright © 2017 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.)
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- 2017
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39. Pregnancy in women with hypertrophic cardiomyopathy: data from the European Society of Cardiology initiated Registry of Pregnancy and Cardiac disease (ROPAC).
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Goland S, van Hagen IM, Elbaz-Greener G, Elkayam U, Shotan A, Merz WM, Enar SC, Gaisin IR, Pieper PG, Johnson MR, Hall R, Blatt A, and Roos-Hesselink JW
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- Adult, Cesarean Section statistics & numerical data, Female, Global Health, Humans, Pregnancy, Pregnancy Outcome epidemiology, Prospective Studies, Registries, Cardiomyopathy, Hypertrophic epidemiology, Pregnancy Complications, Cardiovascular epidemiology
- Abstract
Aims: We report the maternal and foetal outcomes at birth and after 6 months in a cohort of pregnant women with hypertrophic cardiomyopathy (HCM). Although most women with HCM tolerate pregnancy well, there is an increased risk of obstetric and cardiovascular complications., Methods and Results: All pregnant women with HCM entered into the prospective worldwide Registry of Pregnancy and Cardiac disease (ROPAC) were included in this analysis. The primary endpoint was a major adverse cardiovascular event (MACE), which included death, heart failure (HF), thrombo-embolic event, and arrhythmia. Baseline and outcome data were analysed and compared for patients with MACE vs. without MACE and for patients with obstructive HCM vs. non-obstructive HCM. Sixty pregnant women (mean age 30.4 ± 6.0 years) with HCM (41.7% obstructive) were included. No maternal mortality occurred in this cohort. In 14 (23%) patients at least one MACE occurred: 9 (15.0%) HF and 7 (12%) an arrhythmia (6 ventricular and 1 atrial fibrillation). MACE occurred most commonly during the 3rd trimester and postpartum period. In total, 3 (5.0%) women experienced foetal loss. Women with MACE had a higher rate of emergency Caesarean delivery for cardiac reasons (21.4% vs. 0%, P = 0.01). No significant differences in pregnancy outcome were found between women with obstructive and non-obstructive HCM. NYHA functional class of ≥II and signs of HF before pregnancy, were associated with MACE., Conclusion: Although most women with HCM tolerated pregnancy well, cardiovascular complications were not uncommon and predicted by pre-pregnancy status facilitating pre-pregnancy counselling and targeted antenatal care., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.)
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- 2017
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40. Chance of surgery in adult congenital heart disease.
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Verheugt CL, Uiterwaal CS, Vaartjes I, van der Velde ET, Zomer AC, Meijboom FJ, Pieper PG, Post MC, Vliegen HW, Hazekamp MG, Grobbee DE, and Mulder BJ
- Subjects
- Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Disease Progression, Female, Follow-Up Studies, Heart Defects, Congenital epidemiology, Humans, Incidence, Male, Middle Aged, Netherlands epidemiology, Risk Factors, Young Adult, Cardiac Surgical Procedures standards, Forecasting, Health Transition, Heart Defects, Congenital surgery, Registries, Risk Assessment
- Abstract
Background Young patients with congenital heart disease reaching adulthood face mandatory transition to adult cardiology. Their new cardiologist needs to assess the chances of major future events such as surgery. Using a large national registry, we assessed if patient characteristics at the age of 18 years could predict the chance of congenital heart surgery in adulthood. Design and methods Of 10,300 patients from the CONCOR national registry, we used general patient characteristics at age 18 years, underlying congenital heart defect, history of complications, and interventions in childhood as potential predictors of congenital heart surgery occurring from age 18 years up to age 40 and 60 years. Cox regression was used to calculate hazard ratios with 95% confidence intervals. Analyses were performed separately for all congenital heart surgery and for valvular surgery alone. Results Altogether 2427 patients underwent congenital heart surgery after age 18 years, 1389 of whom underwent valvular surgery. Underlying heart defect, male sex, multiple defects, childhood endocarditis, supraventricular arrhythmia, aortic complications and paediatric cardiovascular surgery, independently predicted adult congenital heart surgery. The mean chance of congenital heart surgery was 22% up to age 40 and 43% up to age 60 years; individual chances spanned from 9-68% up to age 40 and from 19-93% up to age 60 years. Conclusion At the time of transition from paediatric to adult cardiology, an easily obtainable set of characteristics of patients with congenital heart disease can meaningfully inform cardiologists about the patient's individual chance of surgery in adulthood. Our findings warrant validation in other cohorts.
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- 2017
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41. Pregnancy-related myocardial infarction.
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Lameijer H, Lont MC, Buter H, van Boven AJ, Boonstra PW, and Pieper PG
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Introduction: The risk of acute myocardial infarction in young women is low, but increases during pregnancy due to the physiological changes in pregnancy, including hypercoagulability. Ischaemic heart disease during pregnancy is not only associated with increased maternal morbidity and mortality, but also with high neonatal complications. Advancing maternal age and other risk factors for cardiovascular diseases may further increase the risk of ischaemic heart disease in young women., Methods: We searched the coronary angiography database of a Dutch teaching hospital to identify women with acute myocardial infarction who presented during pregnancy or postpartum between 2011 and 2013., Results: We found two cases. Both women were in their early thirties and both suffered from myocardial infarction in the postpartum period. Acute myocardial infarction was due to coronary stenotic occlusion in one patient and due to coronary artery dissection in the other patient. Coronary artery dissection is a relatively frequent cause of myocardial infarction during pregnancy. Both women were treated by percutaneous coronary intervention and survived., Conclusion: Physicians should be aware of the increased risk of myocardial infarction when encountering pregnant or postpartum women presenting with chest pain.
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- 2017
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42. Uteroplacental Doppler flow and pregnancy outcome in women with tetralogy of Fallot.
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Kampman MA, Siegmund AS, Bilardo CM, van Veldhuisen DJ, Balci A, Oudijk MA, Groen H, Mulder BJ, Roos-Hesselink JW, Sieswerda G, de Laat MW, Sollie-Szarynska KM, and Pieper PG
- Subjects
- Adult, Arrhythmias, Cardiac diagnostic imaging, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Prospective Studies, Tetralogy of Fallot complications, Tetralogy of Fallot surgery, Echocardiography, Doppler methods, Placenta diagnostic imaging, Tetralogy of Fallot diagnostic imaging, Ultrasonography, Prenatal methods
- Abstract
Objective: Pregnancy in women with surgically corrected tetralogy of Fallot (ToF) is associated with cardiac, obstetric and neonatal complications. We compared uteroplacental Doppler flow (UDF) measurements and pregnancy outcome in women with ToF and in healthy women and aimed to assess whether a relationship exists between cardiac function and UDF in women with ToF., Methods: We evaluated prospectively pregnant women with ToF and healthy pregnant women from the ZAHARA studies. Clinical evaluation, standardized echocardiography and UDF measurements were performed at 20 and 32 weeks' gestation., Results: We included 62 women with ToF and 69 healthy controls. Cardiac complications, mostly arrhythmia, occurred in 8.1% of women with ToF. There was a higher incidence of small-for-gestational age (21.0% vs 4.4%, P = 0.004) and low birth weight (16.1% vs 2.9%, P = 0.009) in the group of women with ToF than in healthy controls. In women with ToF, early diastolic notching of uterine artery waveform at 20 and 32 weeks occurred more frequently (9.8% vs 1.5%, P = 0.034 and 7.0% vs 0%, P = 0.025, respectively) and the umbilical artery pulsatility index at 32 weeks was higher (1.02 ± 0.20 vs 0.94 ± 0.17, P = 0.015) than in healthy controls. Right ventricular function parameters prepregnancy and at 20 weeks' gestation were significantly associated with abnormal UDF. UDF parameters were associated with adverse neonatal outcome., Conclusion: The majority of women with surgically corrected ToF tolerate pregnancy well. However, UDF indices are more frequently abnormal in these women, suggesting impaired placentation. The association of impaired right ventricular function parameters with abnormal UDF suggests that cardiac dysfunction contributes to defective placentation or placental perfusion mismatch and may explain the increased incidence of obstetric and neonatal complications. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd., (Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.)
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- 2017
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43. NT-proBNP and exercise capacity in adult patients with congenital heart disease and a prosthetic valve: a multicentre PROSTAVA study.
- Author
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Schoonbeek RC, Pieper PG, van Slooten YJ, Freling HG, Sieswerda GT, van Dijk AP, Jongbloed MR, Post MC, Bouma BJ, Berger RM, Ebels T, and van Melle JP
- Abstract
Objectives: N-terminal B‑type natriuretic peptide (NT-proBNP) is an important biomarker for the detection of heart failure. Adults with congenital heart disease (ACHD) and a prosthetic heart valve are at risk for heart failure. This study aimed to determine the value of NT-proBNP in ACHD patients with a prosthetic valve and investigate its relationship with cardiac function and exercise capacity., Methods: In this multi-centre cross-sectional observational study, data regarding medical history, echocardiography, exercise testing (VO
2 peak) and laboratory blood evaluation (including NT-proBNP) were collected in ACHD patients with a single prosthetic valve (either homografts, heterografts or mechanical valves)., Results: A total of 306 ACHD patients with pulmonary valve replacement (PVR, n = 139), aortic valve replacement (n = 141), mitral valve replacement (n = 21) or tricuspid valve replacement (n = 5) were investigated. The majority of patients (77 %) were in NYHA class I or II. Elevated NT-proBNP levels (cut-off ≥125 pg/ml) were found in 50 % of the patients, with the highest levels in patients with mitral valve replacements. In this study population, NT-proBNP levels were associated with gender (p = 0.029) and VO2 max (p < 0.001). In PVR patients, NT-proBNP levels were associated with lower VO2 peak, also after adjustment for age, gender and age at valve replacement in a multivariate model (p = 0.015)., Conclusions: In patients with ACHD and a prosthetic valve, elevated NT-proBNP levels are frequently observed despite preserved NYHA class. In PVR patients, a higher NT-proBNP level was associated with a lower VO2 peak. These results may be of importance in the ongoing discussion about the timing of valve replacement in patients with CHD., Competing Interests: Conflict of interestR. C. Schoonbeek, P. G. Pieper, Y. J. van Slooten, H. G. Freling, G. T. Sieswerda, A. P. J. van Dijk, M. R. M. Jongbloed, M. C. Post, B. J. Bouma, R. M. F. Berger, T. Ebels and J. P. van Melle state that they have no competing interest.- Published
- 2016
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44. Cardiac adaption during pregnancy in women with congenital heart disease and healthy women.
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Kampman MA, Valente MA, van Melle JP, Balci A, Roos-Hesselink JW, Mulder BJ, van Dijk AP, Oudijk MA, Jongbloed MR, van Veldhuisen DJ, and Pieper PG
- Subjects
- Adaptation, Physiological, Adult, Echocardiography, Female, Heart diagnostic imaging, Heart Defects, Congenital diagnostic imaging, Humans, Netherlands, Pregnancy, Pregnancy Complications, Cardiovascular diagnostic imaging, Prospective Studies, Retrospective Studies, Stroke Volume, Time Factors, Ultrasonography, Prenatal methods, Ventricular Function, Left, Ventricular Function, Right, Heart physiopathology, Heart Defects, Congenital physiopathology, Pregnancy Complications, Cardiovascular physiopathology
- Abstract
Objective: Pregnancy in women with congenital heart disease (CHD) is associated with deterioration in cardiac function. However, longitudinal data are scarce. This study describes serial changes in cardiac dimensions and function during pregnancy in women with CHD and compares these with healthy pregnant women (controls)., Methods: Eight tertiary centres prospectively enrolled 125 pregnant women with CHD (pregnancy duration <20 weeks). Controls (N=49) were recruited from low-risk midwife practices. Standardised echocardiography at 20 and 32 weeks gestation and 1 year postpartum was performed., Results: Age and parity were comparable between both groups (p>0.1). Left ventricular ejection fraction (LVEF) <45% was present in 3.2% of women with CHD and 14.4% had tricuspid annular plane systolic excursion (TAPSE) <16 mm. Absolute values of ventricular function parameters and diameters were less favourable in women with CHD. No permanent changes occurred in right and left ventricular function parameters and dimensions in women with CHD. The patterns of change in cardiac function and dimensions were comparable between women with CHD and controls, except for LVEF (p=0.026). In women with right-sided CHD the pattern of TAPSE over time differed from controls (p=0.043) (no decrease in TAPSE postpregnancy in CHD). In women with left-sided CHD left ventricular end-diastolic diameter (LVEDD) tended to increase compared with controls (p=0.045)., Conclusions: Absolute levels of ventricular function parameters and diameters differ between CHD and controls, but changes during and after pregnancy are generally comparable. However, different patterns over time seen for TAPSE and LVEDD in women with right-sided and left-sided CHD, respectively, compared with controls indicate the importance of echocardiographic follow-up during pregnancy in women with CHD., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)
- Published
- 2016
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45. High-Risk Cardiac Disease in Pregnancy: Part II.
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Elkayam U, Goland S, Pieper PG, and Silversides CK
- Abstract
Heart disease continues to be the leading cause of nonobstetric maternal morbidity and mortality. Early diagnosis and appropriate care can lead to prevention of complications and improvement of pregnancy outcome. This paper continues the review and provides recommendations for the approach to high-risk cardiovascular conditions during gestation., (Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)
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- 2016
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46. Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases.
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Pinto YM, Elliott PM, Arbustini E, Adler Y, Anastasakis A, Böhm M, Duboc D, Gimeno J, de Groote P, Imazio M, Heymans S, Klingel K, Komajda M, Limongelli G, Linhart A, Mogensen J, Moon J, Pieper PG, Seferovic PM, Schueler S, Zamorano JL, Caforio AL, and Charron P
- Subjects
- Cardiomyopathies etiology, Cardiomyopathies therapy, Cardiomyopathy, Dilated diagnosis, Cardiomyopathy, Dilated etiology, Cardiomyopathy, Dilated therapy, Diagnosis, Differential, Early Diagnosis, Humans, Multimodal Imaging methods, Myocarditis diagnosis, Pedigree, Risk Factors, Cardiomyopathies diagnosis
- Abstract
In this paper the Working Group on Myocardial and Pericardial Disease proposes a revised definition of dilated cardiomyopathy (DCM) in an attempt to bridge the gap between our recent understanding of the disease spectrum and its clinical presentation in relatives, which is key for early diagnosis and the institution of potential preventative measures. We also provide practical hints to identify subsets of the DCM syndrome where aetiology directed management has great clinical relevance., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.)
- Published
- 2016
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47. Pulmonary Valve Replacement After Repair of Pulmonary Stenosis Compared With Tetralogy of Fallot.
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Bokma JP, Winter MM, Oosterhof T, Vliegen HW, van Dijk AP, Pieper PG, Meijboom FJ, Groenink M, Mulder BJM, and Bouma BJ
- Subjects
- Adult, Female, Humans, Male, Pulmonary Valve Stenosis congenital, Abnormalities, Multiple, Cardiac Surgical Procedures methods, Pulmonary Valve surgery, Pulmonary Valve Stenosis surgery, Tetralogy of Fallot surgery
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- 2016
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48. Clinical and psychological characteristics predict future healthcare use in adults with congenital heart disease.
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Schoormans D, Sprangers MA, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, and Mulder BJ
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Surveys and Questionnaires, Type D Personality, Young Adult, Attitude to Health, Heart Defects, Congenital psychology, Patient Acceptance of Health Care psychology, Patients psychology, Quality of Life psychology
- Abstract
Background: To deliver adequate care to patients with congenital heart disease (CHD), it is important to know which patients use what type of care. This knowledge is valuable, as modification of these factors may be used as means to regulate healthcare use. Our objective was to examine the predictive value of psychological characteristics for future healthcare use, independent of clinical characteristics., Methods: In total 845 adult CHD-patients participated in a longitudinal questionnaire study, with a two-year follow-up period. Linear regression analyses with negative binomial log link function were performed predicting healthcare used during the previous year. Psychological predictors were Type D personality, quality of life (QoL), depressive symptoms, trait-anxiety, happiness, optimism, and illness perceptions, independent of the number of co-morbidities, disease complexity and functional status. To control for clustering we included the variable type of centre (regional versus tertiary referral)., Results: Patients who reported more healthcare use had a complex defect, a poor functional status, no Type D personality, and a poor QoL. They moreover felt their CHD had a severe impact on their life and believed their CHD could be managed by themselves or treatment., Conclusions: Healthcare use is not entirely determined by disease complexity and functional status but also by psychological patient characteristics. It can by hypothesised that reducing the negative impact experienced and informing patients about strategies to manage their CHD, will modify their future healthcare use. Additional research is necessary to examine this possibility., (© The European Society of Cardiology 2014.)
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- 2016
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49. Aortic valve prosthesis-patient mismatch and exercise capacity in adult patients with congenital heart disease.
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van Slooten YJ, van Melle JP, Freling HG, Bouma BJ, van Dijk AP, Jongbloed MR, Post MC, Sieswerda GT, Huis In 't Veld A, Ebels T, Voors AA, and Pieper PG
- Subjects
- Adult, Aortic Valve physiopathology, Aortic Valve surgery, Bicuspid Aortic Valve Disease, Exercise Test methods, Female, Heart Valve Prosthesis Implantation methods, Humans, Male, Middle Aged, Netherlands epidemiology, Postoperative Complications diagnosis, Postoperative Complications epidemiology, Postoperative Complications physiopathology, Prevalence, Treatment Outcome, Exercise Tolerance, Heart Defects, Congenital diagnosis, Heart Defects, Congenital etiology, Heart Defects, Congenital physiopathology, Heart Defects, Congenital surgery, Heart Valve Diseases diagnosis, Heart Valve Diseases etiology, Heart Valve Diseases physiopathology, Heart Valve Diseases surgery, Heart Valve Prosthesis adverse effects, Heart Valve Prosthesis standards, Heart Valve Prosthesis Implantation adverse effects, Prosthesis Failure etiology, Registries
- Abstract
Objectives: To report the prevalence of aortic valve prosthesis-patient mismatch (PPM) in an adult population with congenital heart disease (CHD) and its impact on exercise capacity. Adults with congenital heart disease (ACHD) with a history of aortic valve replacement may outgrow their prosthesis later in life. However, the prevalence and clinical consequences of aortic PPM in ACHD are presently unknown., Methods: From the national Dutch Congenital Corvitia (CONCOR) registry, we identified 207 ACHD with an aortic valve prosthesis for this cross-sectional cohort study. Severe PPM was defined as an indexed effective orifice area ≤0.65 cm2/m2 and moderate PPM as an indexed orifice area ≤0.85 cm2/m2 measured using echocardiography. Exercise capacity was reported as percentage of predicted exercise capacity (PPEC)., Results: Of the 207 patients, 68% was male, 71% had a mechanical prosthesis and mean age at inclusion was 43.9 years ±11.4. The prevalence of PPM was 42%, comprising 23% severe PPM and 19% moderate PPM. Prevalence of PPM was higher in patients with mechanical prostheses (p<0.001). PPM was associated with poorer exercise capacity (mean PPEC 84% vs. 92%; p=0.048, mean difference =-8.3%, p=0.047). Mean follow-up was 2.6±1.1 years during which New York Heart Association (NYHA) class remained stable in most patients. PPM showed no significant effect on death or hospitalisation during follow-up (p=0.218)., Conclusions: In this study we report a high prevalence (42%) of PPM in ACHD with an aortic valve prosthesis and an independent association of PPM with diminished exercise capacity., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/)
- Published
- 2016
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50. [Estimation of the jugular venous pressure].
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Hamer JP, Pieper PG, and van den Brink RB
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- Blood Pressure Determination methods, Diagnosis, Differential, Dyspnea diagnosis, Edema diagnosis, Edema etiology, Heart Failure therapy, Humans, Jugular Veins physiology, Treatment Outcome, Central Venous Pressure physiology, Dyspnea etiology, Subclavian Vein physiology
- Abstract
Estimation of jugular venous pressure (JVP) is valuable for the differentiation between dyspnoea of cardiac or pulmonary origin, and for determining the cause of oedema. JVP assessments are useful for evaluation of treatment of right ventricular failure. The correlation between non-invasive JVP and invasive measurement of the central venous pressure (CVP) is remarkably better than previously reported. Correlation between JVP - determined via the external jugular vein - and CVP is excellent when the outcomes are categorised into low, normal and elevated pressure. Optimal measurement configurations include: extended expiration (without Valsalva manoeuvre), and during ventricular diastole. In the literature, these measurement configurations concerning the respiratory cycle and cardiac cycle have not been applied uniformly. To investigate in detail the correlation between JVP and CVP, the methods need to be standardized, and tests performed simultaneously and correctly.
- Published
- 2016
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