691 results on '"Pieper, Karen S."'
Search Results
2. Rhythm versus rate control in patients with newly diagnosed atrial fibrillation – Observations from the GARFIELD-AF registry
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Pope, Marita Knudsen, Hall, Trygve S., Virdone, Saverio, Atar, Dan, John Camm, A., Pieper, Karen S, Jansky, Petr, Haas, Sylvia, Goto, Shinya, Panchenko, Elizaveta, Baron-Esquivias, Gonzalo, Angchaisuksiri, Pantep, and Kakkar, Ajay K
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- 2023
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3. Outcomes of Oral Anticoagulation in Atrial Fibrillation Patients With or Without Comorbid Vascular Disease: Insights From the GARFIELD-AF Registry
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Verheugt, Freek W.A., Fox, Keith A.A., Virdone, Saverio, Ambrosio, Giuseppe, Gersh, Bernard J., Haas, Sylvia, Pieper, Karen S., Kayani, Gloria, Camm, A. John, Parkhomenko, Alexandr, Misselwitz, Frank, Ragy, Hany, ten Cate, Hugo, Keltai, Matyas, and Kakkar, Ajay K.
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- 2023
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4. Residual stroke risk despite oral anticoagulation in patients with atrial fibrillation
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Carlisle, Matthew A., Shrader, Peter, Fudim, Marat, Pieper, Karen S., Blanco, Rosalia G., Fonarow, Gregg C., Naccarelli, Gerald V., Gersh, Bernard J., Reiffel, James A., Kowey, Peter R., Steinberg, Benjamin A., Freeman, James V., Ezekowitz, Michael D., Singer, Daniel E., Allen, Larry A., Chan, Paul S., Pokorney, Sean D., Peterson, Eric D., and Piccini, Jonathan P.
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- 2022
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5. Stroke prevention in patients from Latin American countries with non‐valvular atrial fibrillation: Insights from the GARFIELD‐AF registry
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Jerjes‐Sanchez, Carlos, Corbalan, Ramon, Barretto, Antonio CP, Luciardi, Hector L, Allu, Jagan, Illingworth, Laura, Pieper, Karen S, Kayani, Gloria, and Investigators, for the GARFIELD‐AF
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Hematology ,Heart Disease ,Stroke ,Cardiovascular ,Clinical Research ,Prevention ,Good Health and Well Being ,Aged ,Anticoagulants ,Atrial Fibrillation ,Drug Prescriptions ,Drug Utilization ,Female ,Hemorrhage ,Humans ,Male ,Mexico ,Middle Aged ,Practice Patterns ,Physicians' ,Prospective Studies ,Registries ,Retrospective Studies ,Risk Factors ,South America ,Treatment Outcome ,GARFIELD-AF Investigators ,Latin American ,antithrombotic treatment ,atrial fibrillation ,outcomes ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology - Abstract
BackgroundAtrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular AF (NVAF) from Latin American countries are poorly described.MethodsUsing data from the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF), we examined the stroke prevention strategies and the 1-year outcomes in patients from four Latin American countries: Argentina, Brazil, Chile, and Mexico.ResultsA total of 4162 patients (2010-2014) were included in this analysis. At the time of AF diagnosis, 39.9% of patients were prescribed vitamin K antagonists (VKA) ± antiplatelet (AP) therapy, 21.8% non-VKA oral anticoagulant (NOAC) ± AP, 24.1% AP only and 14.1% no antithrombotic treatment. The proportion of moderate-high risk patients receiving no AC therapy at participating centers was highest in Mexico (46.4%) and lowest in Chile (14.3%). During 1-year follow-up, the rates of all-cause mortality, stroke/SE and major bleeding were: 5.77 (95% CI) (5.06-6.56), 1.58 (1.23-2.02), and 0.99 (0.72-1.36) and per 100 person-years, respectively, which are higher than the global rates across all countries in GARFIELD-AF. Unadjusted rates of all-cause mortality were highest in Argentina, 6.95 (5.43-8.90), and lowest in Chile, 4.01 (2.92-5.52).ConclusionsGARFIELD-AF results describes the marked variation in the baseline characteristics and patterns of antithrombotic treatments in patients with NVAF in four Latin American countries. Over one-third of patients with a moderate-to-high risk of stroke received no AC therapy, highlighting the need for improved management of patients according to national guideline. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
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- 2019
6. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Sawhney, Jitendra PS, Kothiwale, Veerappa A, Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, Allu, Jagan, Pieper, Karen S, Camm, A John, Kakkar, Ajay K, Bassand, Jean-Pierre, Fitzmaurice, David A, Goldhaber, Samuel Z, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G, Misselwitz, Frank, Turpie, Alexander GG, van Eickels, Martin, Verheugt, Freek WA, Kayani, Gloria, Fox, Keith AA, Gersh, Bernard J, Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J, Spyropoulos, Alex, Eikelboom, John, Corbalan, Ramon, Hu, Dayi, Jansky, Petr, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Le Heuzey, Jean-Yves, Darius, Harald, Keltai, Matyas, Kakkar, Sanjay, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Díaz, Carlos Jerjes Sánchez, Cate, Hugo Ten, Atar, Dan, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Mahmeed, Wael Al, Fitzmaurice, David, Hu, DY, Chen, KN, Zhao, YS, Zhang, HQ, Chen, JZ, Cao, SP, Wang, DW, Yang, YJ, Li, WH, Yin, YH, Tao, GZ, Yang, P, Chen, YM, He, SH, Wang, Ying, Wang, Yong, Fu, GS, Li, X, Wu, TG, Cheng, XS, Yan, XW, Zhao, RP, Chen, MS, Xiong, LG, and Chen, P
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Hematology ,Prevention ,Cardiovascular ,Clinical Research ,Heart Disease ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Aged ,Atrial Fibrillation ,Electrocardiography ,Female ,Follow-Up Studies ,Humans ,Incidence ,India ,Male ,Prevalence ,Prognosis ,Prospective Studies ,Registries ,Risk Assessment ,Risk Factors ,Survival Rate ,Thromboembolism ,Time Factors ,Anticoagulant therapy ,Arrhythmia ,Atrial fibrillation ,GARFIELD-AF ,GARFIELD-AF Investigators ,Cardiovascular System & Hematology - Abstract
BackgroundThe Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry.Methods and resultsA total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
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- 2018
7. The importance of the design of observational studies in comparative effectiveness research: Lessons from the GARFIELD-AF and ORBIT-AF registries
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Farjat, Alfredo E., Virdone, Saverio, Thomas, Laine E., Kakkar, Ajay K., Pieper, Karen S., and Piccini, Jonathan P.
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- 2022
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8. Risks associated with discontinuation of oral anticoagulation in newly diagnosed patients with atrial fibrillation: Results from the GARFIELD‐AF Registry
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Cools, Frank, Johnson, Dana, Camm, Alan J., Bassand, Jean‐Pierre, Verheugt, Freek W.A., Yang, Shu, Tsiatis, Anastasios, Fitzmaurice, David A., Goldhaber, Samuel Z., Kayani, Gloria, Goto, Shinya, Haas, Sylvia, Misselwitz, Frank, Turpie, Alexander G.G., Fox, Keith A.A., Pieper, Karen S., and Kakkar, Ajay K.
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- 2021
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9. Bleeding and related mortality with NOACs and VKAs in newly diagnosed atrial fibrillation: results from the GARFIELD-AF registry
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Bassand, Jean-Pierre, Virdone, Saverio, Badoz, Marc, Verheugt, Freek W.A., Camm, A. John, Cools, Frank, Fox, Keith A.A., Goldhaber, Samuel Z., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Kayani, Gloria, Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G.G., van Eickels, Martin, and Kakkar, Ajay K.
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- 2021
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10. Rhythm versus rate control in patients with newly diagnosed atrial fibrillation – Observations from the GARFIELD-AF registry
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Knudsen Pope, Marita, primary, Hall, Trygve S., additional, Virdone, Saverio, additional, Atar, Dan, additional, John Camm, A., additional, Pieper, Karen S, additional, Jansky, Petr, additional, Haas, Sylvia, additional, Goto, Shinya, additional, Panchenko, Elizaveta, additional, Baron-Esquivias, Gonzalo, additional, Angchaisuksiri, Pantep, additional, and Kakkar, Ajay K, additional
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- 2023
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11. Embolic and Other Adverse Outcomes in Symptomatic Versus Asymptomatic Patients With Atrial Fibrillation (from the ORBIT-AF Registry)
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Thind, Munveer, Holmes, DaJuanicia N., Badri, Marwan, Pieper, Karen S., Singh, Amitoj, Blanco, Rosalia G., Steinberg, Benjamin A., Fonarow, Gregg C., Gersh, Bernard J., Mahaffey, Kenneth W., Peterson, Eric D., Reiffel, James A., Piccini, Jonathan P., and Kowey, Peter R.
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- 2018
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12. Determinants and clinical outcomes of patients who refused anticoagulation: findings from the global GARFIELD-AF registry
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Apenteng, Patricia, primary, Virdone, Saverio, additional, Camm, John, additional, Fox, Keith A A, additional, Bassand, Jean-Pierre, additional, Turpie, Alexander G G, additional, Oh, Seil, additional, Brodmann, Marianne, additional, Cools, Frank, additional, Barretto, Antonio C P, additional, Nielsen, Jørn, additional, Haas, Sylvia, additional, Kayani, Gloria, additional, Pieper, Karen S, additional, and Kakkar, Ajay K, additional
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- 2023
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13. Predictors of intracranial hemorrhage in patients with atrial fibrillation treated with oral anticoagulants: Insights from the GARFIELD‐AF and ORBIT‐AF registries.
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Lim, Toon Wei, Camm, Alan John, Virdone, Saverio, Singer, Daniel E., Bassand, Jean P., Fonarow, Gregg C., Fox, Keith A. A., Ezekowitz, Michael, Gersh, Bernard J., Kayani, Gloria, Hylek, Elaine M., Kakkar, Ajay K., Mahaffey, Kenneth W., Pieper, Karen S., Peterson, Eric D., and Piccini, Jonathan P.
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ATRIAL fibrillation ,ORAL medication ,INTRACRANIAL hemorrhage ,TRANSIENT ischemic attack ,ANTICOAGULANTS - Abstract
Background: An unmet need exists to reliably predict the risk of intracranial hemorrhage (ICH) in patients with atrial fibrillation (AF) treated with oral anticoagulants (OACs). Hypothesis: An externally validated model improves ICH risk stratification. Methods: Independent factors associated with ICH were identified by Cox proportional hazard modeling, using pooled data from the GARFIELD‐AF (Global Anticoagulant Registry in the FIELD‐Atrial Fibrillation) and ORBIT‐AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation) registries. A predictive model was developed and validated by bootstrap sampling and by independent data from the Danish National Patient Register. Results: In the combined training data set, 284 of 53 878 anticoagulated patients had ICH over a 2‐year period (0.31 per 100 person‐years; 95% confidence interval [CI]: 0.28–0.35). Independent predictors of ICH included: older age, prior stroke or transient ischemic attack, concomitant antiplatelet (AP) use, and moderate‐to‐severe chronic kidney disease (CKD). Vitamin K antagonists (VKAs) were associated with a significantly higher risk of ICH compared with non‐VKA oral anticoagulants (NOACs) (adjusted hazard ratio: 1.61; 95% CI: 1.25–2.08; p =.0002). The ability of the model to discriminate individuals in the training set with and without ICH was fair (optimism‐corrected C‐statistic: 0.68; 95% CI: 0.65–0.71) and outperformed three previously published methods. Calibration between predicted and observed ICH probabilities was good in both training and validation data sets. Conclusions: Age, prior ischemic events, concomitant AP therapy, and CKD were important risk factors for ICH in anticoagulated AF patients. Moreover, ICH was more frequent in patients receiving VKA compared to NOAC. The new validated model is a step toward mitigating this potentially lethal complication. [ABSTRACT FROM AUTHOR]
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- 2023
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14. Outcomes of Cardiac Catheterization in Patients With Atrial Fibrillation on Anticoagulation in Contemporary in Practice: An Analysis of the ORBIT II Registry
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Sherwood, Matthew W., Piccini, Jonathan P., Holmes, DaJuanicia N., Pieper, Karen S., Steinberg, Benjamin A., Fonarow, Gregg C., Allen, Larry A., Naccarelli, Gerald V., Kowey, Peter R., Gersh, Bernard J., Mahaffey, Kenneth W., Singer, Daniel E., Ansell, Jack E., Freeman, James V., Chan, Paul S., Reiffel, James A., Blanco, Rosalia, Peterson, Eric D., and Rao, Sunil V.
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- 2020
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15. Outcomes and Anticoagulation Use After Catheter Ablation for Atrial Fibrillation
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Freeman, James V., Shrader, Peter, Pieper, Karen S., Allen, Larry A., Chan, Paul S., Fonarow, Gregg C., Gersh, Bernard J., Kowey, Peter R., Mahaffey, Kenneth W., Naccarelli, Gerald, Reiffel, James A., Singer, Daniel E., Go, Alan S., Hylek, Elaine M., Steinberg, Benjamin A., Peterson, Eric D., and Piccini, Jonathan P.
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- 2019
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16. Rhythm versus rate control in patients with newly diagnosed atrial fibrillation – Observations from the GARFIELD-AF registry
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Thrombosis Research Institute (UK), Pope, Marita Knudsen, Hall, Trygve S., Virdone, Saverio, Atar, Dan, Camm, A. John, Pieper, Karen S., Jansky, Petr, Haas, Sylvia, Goto, Shinya, Panchenko, Elizaveta, Barón Esquivias, G., Angchaisuksiri, Pantep, Kakkar, Ajay K., GARFIELD-AF Investigators, Thrombosis Research Institute (UK), Pope, Marita Knudsen, Hall, Trygve S., Virdone, Saverio, Atar, Dan, Camm, A. John, Pieper, Karen S., Jansky, Petr, Haas, Sylvia, Goto, Shinya, Panchenko, Elizaveta, Barón Esquivias, G., Angchaisuksiri, Pantep, Kakkar, Ajay K., and GARFIELD-AF Investigators
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[Background] Investigate real-world outcomes of early rhythm versus rate control in patients with recent onset atrial fibrillation., [Methods] The Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF) is an international multi-centre, non-interventional prospective registry of newly diagnosed (≤6 weeks’ duration) atrial fibrillation patients at risk for stroke. Patients were stratified according to treatment initiated at baseline (≤48 days post enrolment), and outcome risks evaluated by overlap propensity weighted Cox proportional-hazards models., [Results] Of 45,382 non-permanent atrial fibrillation patients, 23,858 (52.6 %) received rhythm control and 21,524 (47.4 %) rate control. Rhythm-controlled patients had lower median age (68.0 [Q1;Q3: 60.0;76.0] versus 73.0 [65.0;79.0]), fewer histories of stroke/transient ischemic attack/systemic embolism (9.4 % versus 13.0 %), and lower expected probabilities of death (median GARFIELD-AF death score 4.0 [2.3;7.5] versus 5.1 [2.8;9.2]). The two groups had the same median CHA2DS2-VASc scores (3.0 [2.0;4.0]) and similar proportions of anticoagulated patients (rhythm control: 66.0 %, rate control: 65.5 %). The propensity-score-weighted hazard ratios of rhythm vs rate control (reference) were 0.85 (95 % CI: 0.79–0.92, p-value < 0.0001) for all-cause mortality, 0.84 (0.72–0.97, p-value 0.020) for non-haemorrhagic stroke/systemic embolism and 0.90 (0.78–1.04, p-value 0.164) for major bleeding., [Conclusion] Rhythm control strategy was initiated in about half of the patients with newly diagnosed non-valvular non-permanent atrial fibrillation. After balancing confounders, significantly lower risks of all-cause mortality and non-haemorrhagic stroke were observed in patients who received early rhythm control.
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- 2023
17. Frequency, Regional Variation, and Predictors of Undetermined Cause of Death in Cardiometabolic Clinical Trials: A Pooled Analysis of 9259 Deaths in 9 Trials
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Fanaroff, Alexander C., Clare, Robert, Pieper, Karen S., Mahaffey, Kenneth W., Melloni, Chiara, Green, Jennifer B., Alexander, John H., Jones, W. Schuyler, Harrison, Robert W., Mehta, Rajendra H., Povsic, Thomas J., Moreira, Humberto G., Al-Khatib, Sana M., Roe, Matthew T., Kong, David F., Mathews, Robin, Tricoci, Pierluigi, Holman, Rury R., Wallentin, Lars, Held, Claes, Califf, Robert M., Alexander, Karen P., and Lopes, Renato D.
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- 2019
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18. Early Risks of Death, Stroke/Systemic Embolism, and Major Bleeding in Patients With Newly Diagnosed Atrial Fibrillation: Results From the GARFIELD-AF Registry
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Bassand, Jean-Pierre, Virdone, Saverio, Goldhaber, Samuel Z., Camm, A. John, Fitzmaurice, David A., Fox, Keith A.A., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Kayani, Gloria, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G.G., van Eickels, Martin, Verheugt, Freek W.A., and Kakkar, Ajay K.
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- 2019
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19. Sitagliptin does not reduce the risk of cardiovascular death or hospitalization for heart failure following myocardial infarction in patients with diabetes: observations from TECOS
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Nauck, Michael A., McGuire, Darren K., Pieper, Karen S., Lokhnygina, Yuliya, Strandberg, Timo E., Riefflin, Axel, Delibasi, Tuncay, Peterson, Eric D., White, Harvey D., Scott, Russell, and Holman, Rury R.
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- 2019
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20. Oral anticoagulation across diabetic subtypes in patients with newly diagnosed atrial fibrillation: A report from the GARFIELD‐AF registry.
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Bassand, Jean‐Pierre, Virdone, Saverio, Camm, A. John, Fox, Keith A. A., Goldhaber, Samuel Z., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Kayani, Gloria, Keltai, Matyas, Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G. G., Verheugt, Freek W. A., and Kakkar, Ajay K.
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ATRIAL fibrillation ,PEOPLE with diabetes ,STROKE ,ANTICOAGULANTS - Abstract
Aims: This study aims to describe both management and prognosis of patients with diabetes mellitus (DM) and newly diagnosed atrial fibrillation (AF), overall as well as by antidiabetic treatment, and to assess the influence of oral anticoagulation (OAC) on outcomes by DM status. Methods: The study population comprised 52 010 newly diagnosed patients with AF, 11 542 DM and 40 468 non‐DM, enrolled in the GARFIELD‐AF registry. Follow‐up was truncated at 2 years after enrolment. Comparative effectiveness of OAC versus no OAC was assessed by DM status using a propensity score overlap weighting scheme and weights were applied to Cox models. Results: Patients with DM [39.3% oral antidiabetic drug (OAD), 13.4% insulin ± OAD, 47.2% on no antidiabetic drug] had higher risk profile, OAC use, and rates of clinical outcomes compared with patients without DM. OAC use was associated in patients without DM and patients with DM with lower risk of all‐cause mortality [hazard ratio 0.75 (0.69‐0.83), 0.74 (0.64‐0.86), respectively] and stroke/systemic embolism (SE) [0.69 (0.58‐0.83), 0.70 (0.53‐0.93), respectively]. The risk of major bleeding with OAC was similarly increased in patients without DM and those with DM [1.40 (1.14‐1.71), 1.37 (0.99‐1.89), respectively]. Patients with insulin‐requiring DM had a higher risk of all‐cause mortality and stroke/SE [1.91 (1.63‐2.24)], [1.57 (1.06‐2.35), respectively] compared with patients without DM, and experienced significant risk reductions of all‐cause mortality and stroke/SE with OAC [0.73 (0.53‐0.99); 0.50 (0.26‐0.97), respectively]. Conclusions: In both patients with DM and patients without DM with AF, OAC was associated with lower risk of all‐cause mortality and stroke/SE. Patients with insulin‐requiring DM derived significant benefit from OAC. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Healthcare Resource Utilization in Patients with Newly Diagnosed Atrial Fibrillation: A Global Analysis from the GARFIELD-AF Registry
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Mantovani, Lorenzo G., Cozzolino, Paolo, Ferrara, Pietro, Virdone, Saverio, Camm, A. John, Verheugt, Freek W. A., Bassand, Jean-Pierre, Turpie, Alexander G. G., Hacke, Werner, Kayani, Gloria, Goldhaber, Samuel Z., Goto, Shinya, Pieper, Karen S., Gersh, Bernard J., Fox, Keith A. A., Haas, Sylvia, Eickels, Martin van, Kakkar, Ajay K., Investigators, on behalf of the GARFIELD-AF Investigators on behalf of the GARFIELD-AF, Mantovani, L, Cozzolino, P, Ferrara, P, Virdone, S, Camm, A, Verheugt, F, Bassand, J, Turpie, A, Hacke, W, Kayani, G, Goldhaber, S, Goto, S, Pieper, K, Gersh, B, Fox, K, Haas, S, van Eickels, M, and Kakkar, A
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Health Information Management ,Leadership and Management ,Health Policy ,Health Informatics ,Article ,atrial fibrillation ,healthcare resource utilization ,inpatient care ,outpatient care ,ddc - Abstract
The management of atrial fibrillation (AF), the most common sustained arrhythmia, impacts healthcare resource utilization (HCRU). This study aims to estimate global resource use in AF patients, using the GARFIELD-AF registry. A prospective cohort study was conducted to characterize HCRU in AF patients enrolled in sequential cohorts from 2012 to 2016 in 35 countries. Components of HCRU studied were hospital admissions, outpatient care visits, and diagnostic and interventional procedures occurring during follow-up. AF-related HCRU was reported as the percentage of patients demonstrating at least one event and was quantified as rate-per-patient-per-year (PPPY) over time. A total of 49,574 patients was analyzed, having an overall median follow-up of 719 days. Almost all patients (99.5%) had at least one outpatient care visit, while hospital admissions were the second most frequent medical contact, with similar proportions in North America (37.5%) and Europe (37.2%), and slightly higher in the other GARFIELD-AF countries (42.0%; namely Australia, Egypt, and South Africa). Asia and Latin America showed lower percentages of hospitalizations, outpatient care visits, and diagnostic and interventional procedures. Analyses of GARFIELD-AF highlighted the vast AF-related HCRU, underlying significant geographical differences in the type, quantity, and frequency of AF-related HCRU. These differences were likely attributable to health service availability and differing models of care.
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- 2023
22. Apixaban following acute coronary syndromes in patients with prior stroke: Insights from the APPRAISE-2 trial
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Sherwood, Matthew W., Lopes, Renato D., Sun, Jie Lena, Liaw, Danny, Harrington, Robert A., Wallentin, Lars, Laskowitz, Daniel T., James, Stefan K., Goodman, Shaun G., Darius, Harald, Lewis, Basil S., Gibson, Michael C., Pieper, Karen S., and Alexander, John H.
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- 2018
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23. Why are outcomes different for registry patients enrolled prospectively and retrospectively? Insights from the global anticoagulant registry in the FIELD-Atrial Fibrillation (GARFIELD-AF)
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Fox, Keith A A, Accetta, Gabriele, Pieper, Karen S, Bassand, Jean-Pierre, Camm, A John, Fitzmaurice, David A, Kayani, Gloria, and Kakkar, Ajay K
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- 2018
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24. Abstract 13544: Race, Ethnicity and Use of Non-Vitamin K Oral Anticoagulants in Patients With AF: The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II)
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Essien, Utibe R, Jackson, Larry R, II, Simon, DaJuanicia N, Ansell, Jack, Blanco, Rosalia, Fonarow, Gregg C, Gersh, Bernard, Kowey, Peter R, Mahaffey, Kenneth W, Pieper, Karen S, Piccini, Jon, Peterson, Eric D, and Singer, Daniel E
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- 2017
25. Guideline-directed medical therapies for comorbidities among patients with atrial fibrillation: results from GARFIELD-AF.
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Camm, Alan John, Steffel, Jan, Virdone, Saverio, Bassand, Jean-Pierre, Fox, Keith A A, Goldhaber, Samuel Z, Goto, Shinya, Haas, Sylvia, Turpie, Alexander G G, Verheugt, Freek W A, Misselwitz, Frank, Herreros, Ramón Corbalán, Kayani, Gloria, Pieper, Karen S, and Kakkar, Ajay K
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ATRIAL fibrillation ,PROPORTIONAL hazards models ,PERIPHERAL vascular diseases ,ORAL medication ,CORONARY artery disease - Abstract
Aims: This study aimed to identify relationships in recently diagnosed atrial fibrillation (AF) patients with respect to anticoagulation status, use of guideline-directed medical therapy (GDMT) for comorbid cardiovascular conditions (co-GDMT), and clinical outcomes. The Global Anticoagulant Registry in the FIELD (GARFIELD)-AF is a prospective, international registry of patients with recently diagnosed non-valvular AF at risk of stroke (NCT01090362). Methods and results: Guideline-directed medical therapy was defined according to the European Society of Cardiology guidelines. This study explored co-GDMT use in patients enrolled in GARFIELD-AF (March 2013–August 2016) with CHA
2 DS2 -VASc ≥ 2 (excluding sex) and ≥1 of five comorbidities—coronary artery disease, diabetes mellitus, heart failure, hypertension, and peripheral vascular disease (n = 23 165). Association between co-GDMT and outcome events was evaluated with Cox proportional hazards models, with stratification by all possible combinations of the five comorbidities. Most patients (73.8%) received oral anticoagulants (OACs) as recommended; 15.0% received no recommended co-GDMT, 40.4% received some, and 44.5% received all co-GDMT. At 2 years, comprehensive co-GDMT was associated with a lower risk of all-cause mortality [hazard ratio (HR) 0.89 (0.81–0.99)] and non-cardiovascular mortality [HR 0.85 (0.73–0.99)] compared with inadequate/no GDMT, but cardiovascular mortality was not significantly reduced. Treatment with OACs was beneficial for all-cause mortality and non-cardiovascular mortality, irrespective of co-GDMT use; only in patients receiving all co-GDMT was OAC associated with a lower risk of non-haemorrhagic stroke/systemic embolism. Conclusion: In this large prospective, international registry on AF, comprehensive co-GDMT was associated with a lower risk of mortality in patients with AF and CHA2 DS2 -VASc ≥ 2 (excluding sex); OAC therapy was associated with reduced all-cause mortality and non-cardiovascular mortality, irrespective of co-GDMT use. Clinical Trial Registration: Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362. Graphical abstract [ABSTRACT FROM AUTHOR]- Published
- 2023
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26. Two-year outcomes of UK patients newly diagnosed with atrial fibrillation : findings from the prospective observational cohort study GARFIELD-AF
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Apenteng, Patricia N., Virdone, Saverio, Hobbs, F. D. Richard, Camm, A. John, Fox, Keith A. A., Pieper, Karen S., Kayani, Gloria, Fitzmaurice, David, HASH(0x5651c9816d00), and investigators*, GARFIELD UK
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RM ,Family Practice ,RC - Abstract
BackgroundThe outcomes of patients newly diagnosed with atrial fibrillation (AF) following the introduction of direct-acting oral anticoagulants are not well known.AimTo determine the 2-year outcomes of patients newly diagnosed with AF, and the effectiveness of oral anticoagulants in everyday practice.Design and settingThis was a prospective observational cohort study in UK primary care.MethodIn total, 3574 patients aged ≥18 years with a new AF diagnosis were enrolled. A propensity score was applied using an overlap weighting scheme to obtain unbiased estimates of the treatment effect of anticoagulation versus no anticoagulation on the occurrence of death, non-haemorrhagic stroke/systemic embolism, and major bleeding within 2 years of diagnosis.ResultsOverall, 65.8% received anticoagulant therapy, 20.8% received an antiplatelet only, and 13.4% received neither. During the study period, the overall incidence rates of all-cause mortality, non-haemorrhagic stroke/systemic embolism, and major bleeding were 4.15 (95% confidence interval [CI] = 3.69 to 4.65), 1.45 (95% CI = 1.19 to 1.77), and 1.21 (95% CI = 0.97 to 1.50) per 100 person–years, respectively. Anticoagulation treatment compared with no anticoagulation treatment was associated with significantly lower all-cause mortality adjusted hazard ratio (aHR) 0.70 (95% CI = 0.53 to 0.93), significantly lower risk of non-haemorrhagic stroke/systemic embolism (aHR 0.39, 95% CI = 0.24 to 0.62), and a non-significant higher risk of major bleeding (aHR 1.31, 95% CI = 0.77 to 2.24).ConclusionThe data support a benefit of anticoagulation in reducing stroke and death, without an increased risk of a major bleed in patients with new-onset AF. Anticoagulation treatment in patients at high risk of stroke who are not receiving anticoagulation may further improve outcomes.
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- 2022
27. Secondary Prevention of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus: International Insights From the TECOS Trial (Trial Evaluating Cardiovascular Outcomes With Sitagliptin)
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Pagidipati, Neha J., Navar, Ann Marie, Pieper, Karen S., Green, Jennifer B., Bethel, M. Angelyn, Armstrong, Paul W., Josse, Robert G., McGuire, Darren K., Lokhnygina, Yuliya, Cornel, Jan H., Halvorsen, Sigrun, Strandberg, Timo E., Delibasi, Tuncay, Holman, Rury R., and Peterson, Eric D.
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- 2017
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28. Serious Infection After Acute Myocardial Infarction: Incidence, Clinical Features, and Outcomes
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Truffa, Adriano A.M., Granger, Christopher B., White, Kyle R., Newby, L. Kristin, Mehta, Rajendra H., Hochman, Judith S., Patel, Manesh R., Pieper, Karen S., Al-Khalidi, Hussein R., Armstrong, Paul W., and Lopes, Renato D.
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- 2012
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29. Comparison of Incidence of Bleeding and Mortality of Men Versus Women With ST-Elevation Myocardial Infarction Treated With Fibrinolysis
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Mehta, Rajendra H., Stebbins, Amanda S., Lopes, Renato D., Califf, Robert M., Pieper, Karen S., Armstrong, Paul W., Van de Werf, Frans, Hochman, Judith S., White, Harvey D., Topol, Eric J., Alexander, John H., and Granger, Christopher B.
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- 2012
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30. Relationship of sustained ventricular tachyarrhythmias to outcomes in patients undergoing primary percutaneous coronary intervention with varying underlying baseline risk
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Mehta, Rajendra H., Starr, Aijing Z., Lopes, Renato D., Piccini, Jonathan P., Patel, Manesh R., Pieper, Karen S., Armstrong, Paul W., and Granger, Christopher B.
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- 2011
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31. Recalibration of the Global Registry of Acute Coronary Events risk score in a multiethnic Asian population
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Chan, Mark Y., Shah, Bimal R., Gao, Fei, Sim, Ling Ling, Chua, Terrance, Tan, Huay Cheem, Yeo, Tiong Cheng, Ong, Hean Yee, Foo, David, Goh, Ping Ping, Surrun, Soondal K., Pieper, Karen S., Granger, Christopher B., Koh, Tian Hai, Salim, Agus, and Tai, E. Shyong
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- 2011
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32. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE)
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Fox, Keith A A, Dabbous, Omar H, Goldberg, Robert J, Pieper, Karen S, Eagle, Kim A, Van de Werf, Frans, Avezum, Álvaro, Goodman, Shaun G, Flather, Marcus D, Anderson, Frederick A, and Granger, Christopher B
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- 2006
33. Challenges and Solutions to Pre- and Post-Randomization Subgroup Analyses
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Desai, Manisha, Pieper, Karen S., and Mahaffey, Ken
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- 2014
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34. Pooled analysis of adverse event collection from 4 acute coronary syndrome trials
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Zimerman, André, Lopes, Renato D., Stebbins, Amanda L., Guimarães, Patrícia O., Haque, Ghazala, Melloni, Chiara, Trollinger, Kathleen, James, Stefan K., Alexander, John H., Tricoci, Pierluigi, Roe, Matthew T., Ohman, Erik Magnus, Mahaffey, Kenneth W., Held, Claes, Tinga, Brian, Pieper, Karen S., and Alexander, Karen P.
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- 2016
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35. Association of standard clinical and laboratory variables with red blood cell distribution width
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Guimarães, Patrícia O., Sun, Jie-Lena, Kragholm, Kristian, Shah, Svati H., Pieper, Karen S., Kraus, William E., Hauser, Elizabeth R., Granger, Christopher B., and Newby, Kristin L.
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- 2016
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36. Renal failure in patients with ST-segment elevation acute myocardial infarction treated with primary percutaneous coronary intervention: Predictors, clinical and angiographic features, and outcomes
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Vavalle, John P., van Diepen, Sean, Clare, Robert M., Hochman, Judith S., Weaver, Douglas W., Mehta, Rajendra H., Pieper, Karen S., Patel, Manesh R., Patel, Uptal D., Armstrong, Paul W., Granger, Christopher B., and Lopes, Renato D.
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- 2016
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37. Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus
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Thompson, Alexander J., Muir, Andrew J., Sulkowski, Mark S., Ge, Dongliang, Fellay, Jacques, Shianna, Kevin V., Urban, Thomas, Afdhal, Nezam H., Jacobson, Ira M., Esteban, Rafael, Poordad, Fred, Lawitz, Eric J., McCone, Jonathan, Shiffman, Mitchell L., Galler, Greg W., Lee, William M., Reindollar, Robert, King, John W., Kwo, Paul Y., Ghalib, Reem H., Freilich, Bradley, Nyberg, Lisa M., Zeuzem, Stefan, Poynard, Thierry, Vock, David M., Pieper, Karen S., Patel, Keyur, Tillmann, Hans L., Noviello, Stephanie, Koury, Kenneth, Pedicone, Lisa D., Brass, Clifford A., Albrecht, Janice K., Goldstein, David B., and McHutchison, John G.
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- 2010
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38. Patterns of discharge antiplatelet therapy and late outcomes among 8,582 patients with bleeding during acute coronary syndrome: A pooled analysis from PURSUIT, PARAGON-A, PARAGON-B, and SYNERGY
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Chan, Mark Y., Sun, Jie L., Wang, Tracy Y., Lopes, Renato D., Jolicoeur, Marc E., Pieper, Karen S., Rao, Sunil V., Newby, L. Kristin, Mahaffey, Kenneth W., Harrington, Robert A., and Peterson, Eric D.
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- 2010
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39. Cardioversion in patients with newly diagnosed non-valvular atrial fibrillation: observational study using prospectively collected registry data
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Pope, Marita Knudsen, primary, Hall, Trygve S, additional, Schirripa, Valentina, additional, Radic, Petra, additional, Virdone, Saverio, additional, Pieper, Karen S, additional, Le Heuzey, Jean-Yves, additional, Jansky, Petr, additional, Fitzmaurice, David A, additional, Cappato, Riccardo, additional, Atar, Dan, additional, Camm, A John, additional, and Kakkar, Ajay K, additional
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- 2021
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40. Early Risks of Death, Stroke/Systemic Embolism, and Major Bleeding in Patients With Newly Diagnosed Atrial Fibrillation
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Voelkel-Babyesiza, R., Chen, D. D., Jaufeerally, F. R., Lee, Y. M., Lim, G., Lim, W. T., Thng, S., Yap, S. Y., Yeo, C., Oh, S., Pak, H. N., Kim, J-B, Kim, J. H., Jang, S-W, Kim, D. H., Ryu, D. R., Park, S. W., Kim, D-K, Choi, D. J., Oh, Y. S., Cho, M-C, Kim, S-H, Jeon, H-K, Shin, D-G, Park, J. S., Park, H. K., Han, S-J, Sung, J. H., Nam, G-B, On, Y. K., Lim, H. E., Kwak, J. J., Cha, T-J, Hong, T. J., Park, S. H., Yoon, J. H., Kim, N-H, Kim, K-S, Jung, B. C., Hwang, G-S, Kim, C-J, Worthy, V, Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V, Orosco, C., Mooso, B., Minardo, J., Merritt, D., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Jasinski, S., Hicks, T., Herrick, C., Henson, L., Headlee, M., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Gentry, P., Fielder, D., Ferdinand, K., Felpel, S., Evans, L., Eley, M., Dickerson, A., DePauw, J., Congal, S., Cervellione, K., Cassidy, D., Canova, M., Cameron-Watts, J., Browne, A., Brown, A., Bowers, S., Bentley, M., Bartlett, M., Asafu-Adjaye, N., Treasure, C., Nishijima, D., Pitta, S., Duffy, P., Noveck, H., Ison, R., Alberts, M., Remmel, K., Theodoro, D., Diercks, D., Delafontaine, P., Ahmed, W., Reddy, R., Haque, I, Gutowski, T., Alfieri, A., Beach, S., Miller, S., Williams, M., Mendelson, R., Falkowski, S., Franco, M., Cox, M., Kutayli, W. M., Ferrick, K., Quick, A., Wilson, V, Mullen, P., Garcia, J., Blumberg, E., Rama, P., Canosa, R., Goldhaber, S. Z., Thanzeel, M., Sharma, R., Sharma, N., Mohamed, R., Maqsood, I, Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Abu-Mahfouz, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V, Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Siebert, H., Bayat, J., Kettles, D., Zaatout, E., Tawfik, M., Taha, N., Soliman, A., Sobhy, M., Setiha, M., Samir, S., Sami, N., Salem, H., Reda, M., Reda, A., Ohanissian, A., Nawar, M., Mowafy, A., Khairy, T., Katta, A., Elkhadem, M., El-Etreby, A., Elbahry, A., El Etriby, S., El Din, M. G., Abou Seif, S. K., Abd El-Aziz, A., Ragy, H., Wright, D., Wong, S., Trahey, T., Stevenson, J., Spearson, S., Snell, L., Schulman, S., Sas, G., Robinson, M., Roberts, P., Raines, M., Pinter, A., Petrie, F., Pandey, M., Otis, R., Otis, J., Neas, I, Navratil, J., Moor, R., Mangat, I, Lewis, S., Lewis, C., Largy, J., Kwan, L., Kornder, J., Korley, V, Kim, R., Kelly, S., Kahlon, R., Jethoo, G., Jean, C., Jackson, A. M., Hines, K., Hines, C., Haveman, K., Gulliver, W., Grenier, M-C, Fox, B., Fournier, D., Ferleyko, L., Fearon, A., Farquhar, D., Ewert, A., Dunnigan, J., Douglass, S., Dorian, P., Djaidani, Z., Denis, I, Dehghani, P., Daheb, S., Cleveland, T., Clarke, B., Carroll, L., Burke, E., Breakwell, L., Bignell, N., Bigcanoe, J., Bergeron, C., Beaudry, K., Aves, T., Aro, L., Ahmad, K., Bonet, J., Ramjattan, B., Cha, J., Lavoie, A., Parkash, R., Fikry, S., Vizel, S., MacDonald, P., Angaran, P., Coutu, B., Schweitzer, B., Hruczkowski, T., Dhillon, R., Dresser, G., Nadeau, R., Du Preez, M., Poirier, G., Heath, J., Berlingieri, J., Ayala-Paredes, F., Beaudry, P., Leader, R., Cheung, S., Pandey, A. S., Gupta, M., Luton, R., Eikelboom, J., Spyropoulos, A., Connolly, S. J., Wong, K., Wilford, E., Wallis, L., Waldman, A., Vorster, M., Tsay, I. M., Thompson, S., Tarrant, J., Swaraj, K., Sutcliffe, S., Stoyanov, N., Singleton, C., Singh, C., Shrestha, P., Shone, S., Setio, H., Seremetkoska, M., Sanders, L., Rose, J., Raynes, S., Ratcliffe, M., Rashad, H., Preston, S., Plotz, M., Paul, V, Patching, T., Patching, K., Parsons, L., Palmer, J., O'May, V, Oldfield, G., Nagalingam, V, Myers, J-D, Mussap, C., Morrison, H., McKeon, L., McIntosh, C., McCarthy, C., MacKenzie, M., Mackay, S., Leung, D., Lehman, S., Lehman, M., Lawlor, V, Kassam, I, Juergens, C., Johnson, K., Jacobson, B., Hoffmann, B., Hesketh, L., Hegde, M. P., Hayes, K., Modi, M. H., Grabek, T., Gibbs, J., Geraghty, R., Fitzpatrick, D., Fetahovic, T., Ferreira-Jardim, A., Eslick, R., Eskandari, M., Duroux, M., Dolman, M., Dixon, S., Dimitri, H., Cresp, D., Conway, B., Connelly, A., Carlton, L., Campo, M., Buckley, E., Boys, J., Bonner, M., Black, A., Beveridge, R., Batta, C., Barry, L., Aggarwala, A., Faunt, J., Carroll, P., Starmer, G., Rogers, J., Lee, A., Binnekamp, M., Jepson, N., Arstall, M., Astridge, P., Choi, A., O'Donnell, D., Crimmins, D., Blombery, P., Phan, T., Ayres, B., Zimmett, L., French, J., Eccleston, D., Kiat, H., Colquhoun, D., Catanchin, A., Coulshed, D., Kilian, J., Roberts-Thomson, P., Lehman, R., Abhayaratna, W., Van Gaal, W., Singh, B., Blenkhorn, A., Gibbs, H., Thomson, A., Thomas, N., Sword, A., Stoddart, H., Simper, H., Simmons, P., Shewring, J., Seamark, C., Saunders, P. B., Rogers, G., Rickenbach, M., Reed, R., Redpath, D., Randfield, S., Powell, K., Nadaph, M., Muvva, R., Munro, I, Lomax, L., Jeffers, L., Jacobs, P., Hay, A., Halpin, A., Goram, J., Fox, R., Flynn, A., Dooldeniya, C., Dobson, S., Cartwright, S., Bennett, J., Ayers, J., A'Court, C., Ahmad, S., Pugsley, M., Gunasegaram, J., Wong, M., Cooke, P., Beattie, A., McEleny, P., Wastling, R., McGinty, P., Bandrapalli, M., Liley, C., Vinson, P., Zaman, K., Davies, T., Forshaw, K., Veale, R., Wilkinson, J., Geatch, D., Estifano, S., Myhill, T., Lucraft, L., Batson, R., Choi, H., Stephenson, T., Hargreaves, N., Schatzberger, T., Davies, S., Baron, R. T., Haria-Shah, R., Bunney, R., Boon, M., Wong, T., Sterry, M., Shepherd, D., Walton, S., Jackson, D., Ward, B., Coates, S., Heer, A., Roberts, N., Coulson, W., Peters, S., Wilson, A., Khalaque, S., Choudhary, F., Sabir, A., Rothwell, A. C., Kim, D. B., Edwards, D., Braddick, M., Mannion, S., Aylward, M., Oliver, R., Hawkins, C., Galloway, S., Sharma, P., Heath, R., Danielsen, M., Neden, C. A., Stuart, E., Davies, R., Hart, N., Ali, A., Patel, J. R. A., Pinnock, H., Roome, P. C., Vercoe, S., Hodgins, I, Webster, J., Dau, H. S., Kamath, R., Lowe, S., Smith, R. N., Burns, G., Conn, P., Warke, A., Mulholland, C., Poland, K., McLeod, A. J., Glencross, S., Gibbons, L., Haq, I. U., Little, H., Barrow, S., Butter, K. C., Howard, M., Zaidi, S. M. A., Chigbo, C., Thompson, R., Walls, N., Hutton, C., Jacobs, M., Abushal, S., Davies, E., Oliver, J. L., Priyadharshan, R., Rogers, S., Milne, K., Parfitt, M., Wakeling, J., Alborough, E., Kelsall, A. R., Fooks, T., Fisher, E., Litchfield, J., Bisatt, J., Clark, M., Gray, D., Bird, N., Vishwanathan, B., Howitt, A., Strieder, E., Gilliland, A., de Kare-Silver, N., Sathananthan, S., Cairns, J., Willcock, W., Ahmad, N., Sarai, B., Watson, E., Thomas, M. J., Jones, K. P., Van Zon, G., Bradshaw, C., Cumberlidge, D. F., Douglas, K., Ladha, K., Saigol, M., Wong, S. W., Patel, R. P., Lumley, L., Murdoch, W., Kernick, D., Eden, J., Weeks, P., Jones, C. P., Ainsworth, P., Davies, J. A., Russell, D., Sinha, B., Railton, T., Gallagher, A., Pandya, P., Matthews, J., Wadeson, P., Thurston, S., West, R., Stipp, Y., Macey, N., Scouller, F., Evans, P., Lumb, W., Wetherwell, S., Aldegather, J., Oginni, O., Giles, C., Jones, H., Sharp, H., Jefferies, A., Richardson, M., Paul, C., Seamark, D., Tragen, D., Taylor, G., St Joseph, V, Thompson, J., Fairhead, S., Franklin, S., Wilson, P., Ramesh, C., Aziz, M., Paul, N., Stokes, M., Wakeman, A., Hutchinson, P., Bilas, R., Sircar, S., Singal, A., Suryani, S., Wagner, H., Gooding, T., Williams, A., McDonnell, J., Pickavance, G., Kainth, M. S., Ross, A., Jhittay, P. S., Leese, J., Evans, R., Saunders, P., Goodwin, D., Chauhan, N., Fitzmaurice, D., Varenov, V., Todoriuk, L., Stets, R., Shumakov, O., Sapatyi, A., Romanova, O., Romanenko, O., Rasputina, L., Pyvovar, S., Proshak, O., Plevak, D., Petrovskyy, R., Pavelko, M., Palamarchuk, O., Ovdiienko, T., Nemtsova, V, Mospan, M., Mochonyi, V, Medentseva, O., Matova, O., Kizim, S., Khyzhnyak, O., Kaplan, P., Kamenska, E., Ivanov, A., Daniuk, I, Chabanna, O., Burdeuna, L., Berko, G., Belegai, R., Fushtey, I, Tykhonova, S., Yagensky, A., Kraydashenko, O., Stanislavchuk, M., Sychov, O., Svyshchenko, Y., Kovalskyi, I, Koval, O., Ushakov, O., Mostovoy, Y., Serediuk, N., Kupnovytska, I, Kraiz, I, Zhurba, S., Karpenko, O., Tseluyko, V, Rudyk, I, Parkhomenko, A., Winnik, S., Saga, E., Henriette, I, Guinand, A., Grau, A., Elise, G., Bruegger, J., Amstutz, D., Debrunner, J., Beer, J. H., Steffel, J., Thorsen, C., Stjernberg, M., Skoglund, K., Shayesteh, M., Samuelsson, J., Rosenberg, K., Risbecker, K., Pedersen, A., Osberg, A., Olofsson, A., Ohlin, A-M, Nilsson, C., Millborg, M., Mansson, K., Mannermyr, A., Lindholm, C-J, Lindberg, A., Lettenstrom, A., Kusiak, D., Koch, A., Kangert, R-M, Jansson, J-H, Jansson, B., Jaensson, P., Hahn, S., Grassjo, C., Floren, K., Eriksson, G-B, Ekstrand, A-B, Dzeletovic, S., Bonkowski, G., Al-Khalili, F., Ahlmark, H., Ahbeck, E., Aaroe, H., Stalby, P., Hot-Bjelac, A., Thulin, J., Engdahl, J., Bernsten, F., Martinsson, B., Malmqvist, L., Andersson, A., Jensen, S. A., Karlsson, J-E, Crisby, M., Romberg, K., Timberg, I, Eriksson, B., Platonov, P., Handel, H., Thorne, K., Svensson, P., Lindvall, H., Ohlsson, A., Ericsson, M., Kadir, K., Hajimirsadeghi, A., Bothin, C., Benson, L., Andersson, L. (Lisbeth), Andersson, L. (Lars), Gustavsson, M., Olsson, L-B, Lindh, A., Liu, B., Svard, G., Borjesson, U., Egilsson, A., Elmersson, M., Henriksson, K., Linden, J., Wirdby, A., Rosenqvist, M., Ubeda Pastor, M., Torres Marques, J., Torres, C., Tobajas, G., Terns Riera, M., Teixido Fontanillas, M., Sorribes Lopez, J., Simon Valero, C., Sierra, N., Serralvo, E., Seoane Blanco, A., Senan Sanz, M. R., Santolaya, C., Sanchez Parra, S., Sanchez Mendez, L., Sanchez Calderon, P., Saez Jimenez, S., Rodriguez Garcia, M., Rodriguez, E., Rodrigo, C., Roca Saumell, C., Roca, M., Robiro Robiro, X., Rivera, R., Riquelme Sola, L., Rios, V, Rincon Diaz, L. M., Quintern, V, Prieto, I, Perez Carasa, M., Pereda Armayor, M., Pena Garcia, E., Pareja Ibar, I., Palomo Merchan, N., Otero Tomera, D., Ortiz Cortes, C., Ortega, V. M., Orellana Figueroa, H. N., Negrete Palma, A., Munoz Munoz, R. B., Moure Gonzalez, M., Montes, D., Montero Alia, P., Molina, M., Millan, G., Mendez Zurita, F., Mazon, P., Martinez Mena, M., Martin Vila, A., Marcus, S., Mara Guerra, J., Manzanal Rey, A., Lopez, M., Llobet Molina, M., Lezcano Gort, L. E., Lasuncion, I, Lage Bouzamayor, M. B., Juan Salvadores, P., Jimenez Fernandez, M. J., Iglesias Garcia, A., Hevia Rodriguez, E., Herrero Maeso, B., Gutierrez del Val, M. del C., Guerrero Molina, A., Grigorian, L., Gonzalez, P., Gonzales Segovia, A., Gomez Perez, Y., Gomez, C., Gines Garcia, C., Gavira Saenz, M., Garcia Millan, V, Garcia Bermudez, M., Fosch, J., Ferrer, A., Fernandez Mas, E., Fernandez Escobar, E., Fernandez, M., Espallargas, A., Elorriaga Madariaga, A., Domenech Borras, A., Diaz Lopez, C. M., Dachs, M., Cotilla Marco, M., Costas, S., Prego de Faria, J. Costa Pinto, Cortada Cabrera, A., Codinachs Alsina, R., Cebollada del Misterio, M., Castro Fernandez, D., Ahn, J. J., Chow, J. H., Foo, C. G., Ching, C. K., Lim, T. 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(Kazuki), Sasaki, T., Sasaki, A., Sasaguri, H., Sasagawa, Y., Samejima, Y., Sakamoto, Y., Sakamoto, N., Sakai, H., Saito, Y., Otaki, E., Ota, A., Oriso, S., Pearce, Y. Onuki, Ono, T., Ono, H., Okuyama, M., Okita, H., Okamoto, K., Okada, M., Ohara, N., Ogawa, T., Nozoe, M., Nomura, S., Nomura, K., Niwa, I, Nishizawa, K., Nishioka, H., Nishino, K., Nishihata, Y., Nishida, Y., Niinuma, H., Niijima, Y., Nariyama, J., Nanke, T., Nakazato, R., Nakayama, T., Nakanishi, N., Nakamura, R., Nakamura, M., Nakahara, S., Nakagomi, A., Nagata, H., Nagata, E., Nagai, S. (Shunichi), Nagai, S. 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B., Marquand, A., Destrac, S., Gutknecht, P., Guziewicz, M., Jackun-Podlesna, A., Jaguszewska, G., Jankielewicz, J., Jaremczuk-Kaczmarczyk, A., Orlov, Y., Jargiello-Baszak, M., Jarzebowski, A., Osmolovskaya, Y., Jaskulska-Niedziela, E., Ovsannikova, A., Jaworska-Drozdowska, M., Kabat, J., Piot, O., Platonov, D., Rachkova, S., Sinitsina, O., Delarche, N., Cebron, J-P, Speshilova, S., Suslova, O., Ushakov, A., Kaczmarzyk-Radka, A., Kalin, K., Boveda, S., Guenoun, M., Kaliszczak, R., Kiliszek, M., Klata, M., Kluczewski, M., Guedj-Meynier, D., Galley, D., Ohayon, J., Assouline, S., Zuber, M., Amarenco, P., Ellie, E., Kadouch, J., Fournier, P-Y, Huberman, J-P, Lemaire, M., Rodier, G., Milandre, L., Vandamme, X., Sibon, I, Neau, J-P, Mahagne, M. H., Mielot, A., Bonnefoy, M., Churet, J-B, Navarre, V, Sellem, F., Monniot, G., Boyes, J-P, Doucet, B., Martelet, M., Obadia, D., Crousillat, B., Mouallem, J., Bearez, E., Nazeyrollas, P., Brugnaux, J. P., Fedorowsky, A., Casassus, F., Berneau, J-B, Chemin, F., Falvo, N., Perron, J-M, Poulard, J-E, Barreau, A., Beltra, C., Corrihons, E., Decarsin, N., Dubois, B., Ducasse, E., Giry, X., Kemmel, A., Ledure, S., Lemaire, N., Robin, F., Rosolin, N., Sanchez, D., Suissa, A., Darius, H., Koeniger, G., Purr, J., Gerbaulet, U., Kellner, B-T, Kopf, A., Schaefer, T., Zauzig, H., Riegel, P., Hohensee, H., Eissfeller, E., Eder, W., Rehling, G., Glatzel, D., Zutz, S., Heinz, G-U, Menke, H., Pustelnik, A., Sandow, P., Ludwig, N., Wiswedel, H., Wildenauer, W., Axthelm, C., Schwarz, T., Babyesiza, A., Stuchlik, G., Zimny, H-H, Kropp, M., Kahl, F., Caspar, A., Omankowsky, S., Laessig, T., Hartmann, H-J, Lehmann, G., Bindig, H-W, Hergdt, G., Reimer, D., Hauk, J., Dorsch, W., Dshabrailov, J., Michel, H., Rapp, K-A, Vormann, R., Mayer, P., Horstmeier, U., Kobielusz-Gembala, I, Kochanska, E., Kociolek, D., Eissing, V, Hey, H., Leuchtgens, H., Lilienweiss, V, Kolitsch, K., Schubert, C., Lauer, H., Buchner, T., Brauer, G., Kamin, S., Mueller, K., Abdel-Qader, M., Baumbach, S., Ebert, H-H, Schwencke, C., Schellong, S., Bernhardt, P., Karolyi, L., Sievers, B., Haverkamp, W., Salbach, P., Roehnisch, J-U, Schoen, S., Erdle, W., Mueller, T., Mueller, H., Mitrovic, V, Babjakova, Z., Bergner, K., Claussen, H., Boehme, S., Ausen, K., Bonin, K., Buckert, D., Busch, F., Dichristin, U., Diez, S., Fleck, A., Flint, K., Fritz, C., Frommhold, R., Antonsen, H., Gehre, J., Geyer, J., Grytzmann, A., Hahn, M., Helgert, K., Berg-Johansen, J., Hubert, K., Henrichsen, S. Hoegh, Oien, T., Christersson, P., Kolodzinska, A., Kirchner-Volker, K., Svilaas, A., Klein, V, Kroll, D., Ghezai, B., Krueger, A., Lehmann, R., Mann, L., Maselli, A., Menken, G., Mikes, K., Mortan, H., Nasser, N., Nicolaus, D., Plauskat, A., Pomper, L., Quietzsch, A., Ravenhorst, C., Komlo, A., Konopka, A., Korczowska, E., Kowal, E., Kowalczyk, H. K., Kremis, E., Kruczyk, D., Krzesiak-Lodyga, A., Krzyzanowski, M., Kurdzielewicz, W., Kustrzycka-Kratochwil, D., Lesniewska-Krynska, D., Leszczynski, J., Lewicka, E., Lichota, E., Lip, K., Loboz-Rudnicka, M., Luka, J., Volodicheva, O., Zemlianskaia, O., Zhirov, I, Lysek-Jozefowicz, A., Machnikowska, M., Majewska, K., Mariankowski, R., Ostrem, A., Skjelvan, G., Hallaraker, A., Markiewicz, A., Erga, K., Hole, T., Gjertsen, E., Sirnes, P. A., Mazur, M., Metzgier-Gumiela, A., Berge, E., Atar, D., Westerman, L., van Putten, J. J., van Leeuwen, G., van der Kley, T., Miedlar, E., van de Loo, R., Mielcarek, M., Neubauer-Geryk, J., Monako, G., Medvedeva, T., Machilskaya, O., Lileeva, E., Lebedeva, O., Niedek, J., Niemirycz-Makurat, A., Kuvanova, M., Kurylo, B., Kupriyanova, T., Kungurtseva, O., Kuchuk, P., Kropova, O., Nowak, A., Nowak, S., Zhuravleva, E., Zotova, I, Korneeva, O., Konyushenko, D., Vinolas, X., Alvarez Garcia, P., Kolesova, T., Ivanova, Y., Lopez Fernandez, M. F., Gurmach, M., Tercedor, L., Gubanov, A., Tranche Iparraguirre, S., Toran Monserrat, P., Marquez Contreras, E., Isart Rafecas, J., Motero Carrasco, J., Gorshkova, T., Opielowska-Nowak, B., Garcia Pavia, P., Gomez Pajuelo, C., Moro Serrano, C., Gorbunova, E., Iglesias Alonso, L. F., Erofeeva, S., Grande Ruiz, A., Ozgowicz, M., Pawelska-Buczen, A., Merce Klein, J., Gonzalez Juanatey, J. R., Baron Esquivias, G., Monte Collado, I, Palacin Piquero, H., Brotons Cuixart, C., Rodriguez Morato, M., Llibre, J. Bayo, Corros Vicente, C., Vida Gutierrez, M., Epelde Gonzalo, F., Almeida Fernandez, C. A., Del Val Plana, N., Escriva Montserrat, E., Montero Alia, J. J., Barreda Gonzalez, M., Moleiro Oliva, M. A., Iglesias Sanmartin, J., Jimenez Gonzalez, M., Dumikyan, A., Rodriguez Alvarez, M., Herreros Melenchon, J., Ripoll Vera, T., Ridocci Soriano, F., Garcia Riesco, L., Marco Macian, M. D., Quiles Granado, J., Jimenez Navarro, M., Cosin Sales, J., Vaquer Perez, J. V., Pawlik-Rak, E., Chugunnaya, S., Vazquez Caamano, M., Arcocha Torres, M. F., Marcos Gomez, G., Iniguez Romo, A., Prieto Diaz, M. A., Bitakova, F., Alonso, C. (Carmela), Alonso, C. (Concepcion), Alvarez, D., Alvarez, M., Belenkova, Y., Amaro, M., Andere, N., Aracil Villar, J., Batalov, R., Armitano Ochoa, R., Austria, A., Agakhanyan, A., Barbeira, S., Barraquer Feu, E., Uppelschoten, B., Reichelt, C., Piotrowicz, R., Tonino, P., Reimer, C., Schaefer, B., Scharrer, S., Schirmer, K., Schmidt, K., Schoene, R., Schulze, J., Schuppe, M., Simon, S., Sommer, S., Spranger, K., Talkenberger, A., Tauber, K., Tetlak, A., Toennishoff, T., Bartes, A., Voigts, B., Weiser, U., Wesendorf, S., Wildenauer, S., Wolf, T., Wurziger, J., Zak, J., Zauzig, H-D, te Kaat, J., Ziefle, S., Zincke, S., Keltai, M., Vangel, S., Szalai, G., Merkely, B., Kancz, S., Boda, Z., Nagy, A., Laszlo, Z., Matoltsy, A., Gaszner, B., Polgar, P., Habon, T., Noori, E., Juhasz, G., Kanakaridisz, N., Szentpeteri, I, Juhasz, F., Vertes, A., Papp, A., May, Z., Stallinga-de Vos, A., Ferenczi, J., Egyutt, M., Engelthaler, G., Fulop, E., Gombos, P., Gulyas, D., Jen, P., Edin, A., Becerra Munoz, V, Gyorke, E. Kiralyhazine, Kovacs, M., Levang, S. Kovacsne, Marianna, S., Radics, Z., Bermudez Jimenez, F. J., Branjovich Tijuan, A., Cabeza Ramirez, J., Cabrera Ramos, M., Calvo Martinez, E., Campo Moreno, M., Cancho Corchado, G., Casanova Gil, M., Castillo Orive, M., Pronk, A., Ptaszynski, P., Raczynska, A., Rogowski, W., Mulder, R., Melman, P., Romanek, J., Romaszkiewicz, R., Krikken, J., Rostoff, P., Roszczyk, N., Rozewska-Furmanek, D., Rychta, J., Koomen, E. M., Rzyczkowska, B., Sidor, A., Skalska, J., Smichura, M., Splawski, M., Staneta, P., Staniszewska, E., Starak-Marciniak, J., Stopyra-Poczatek, M., Sukiennik-Kujawa, M., Szafranski, J., Szalecki, P., Szczepanska, A., Szkrobka, W., Szuchnik, E., Szulowska, A., Kloosterman, T., Kelderman, M., Szumczyk-Muszytowska, G., Szwoch, M., Jetten, W., Traczyk, T., Troszczynska, M., Trzcinski, G., Tybura, S., Walasik, P., Wegrzynowska, M., Wesolowska, K., Wieczorek, W., Wierzbicka, A., Wilczewski, P., Wilgat-Szecowka, M., Wojewoda, P., Wojnowski, L., Wrobel, M., Zakutynska-Kowalczyk, K., Zyczynska-Szmon, M., Panchenko, E., Eltishcheva, V, Libis, R., Tereshchenko, S., Popov, S., Kamalov, G., Belenky, D., Zateyshchikova, A., Kropacheva, E., Kolesnikova, A., Nikolaev, K., Egorova, L., Khokhlov, A., Yakupov, E., Poltavskaya, M., Zateyshchikov, D., Drapkina, O., Vishnevsky, A., Barbarash, O., Miller, O., Aleksandrova, E., Chizhov, P., Sydo, N., Szalo, R., Szilagyi, A., Sergeev, M., Sztanyik, F., Shutemova, E., Vandrus, B., Agnelli, G., Mazur, E., Ambrosio, G., Tiraferri, E., Santoro, R., Testa, S., Di Minno, G., Moia, M., Caimi, T. M., Martini, G., Tessitori, M., Cappelli, R., Poli, D., Quintavalla, R., Melone, F., Cosmi, F., Pizzini, A., Piseddu, G., Fanelli, R., Latella, C., Santi, R., Pancaldi, L., De Cristofaro, R., Palareti, G., De Blasio, A., Zrazhevskiy, K., Novikova, T., Kostenko, V, Moiseeva, Y., Polkanova, E., Uriarte, J. Salerno, Minetti, F., Pogliani, E. M., Lonati, L. M., Accogli, M., Ciampani, N., Malengo, S., Feola, M., Raisaro, A., Fattore, L., Grilli, P., Germini, F., Settimi, M., Alunni, M., Sobolev, K., Rossovskaya, M., Duranti, G., Tedeschi, L., Zubeeva, G., Shapovalova, Y., Baglioni, G., Avanzino, G., Berardi, M., Pannacci, V, Giombolini, A., Nicoli, S., Scarponi, T., Allasia, B., Ricciarini, P., Nasorri, R., Argena, A., Bossolasco, P., Ronchini, P., Filippi, A., Tradati, F., Bulla, C., Donzelli, L., Foppa, L., Bottarelli, M. L., Tomasello, A., Mauric, A., Femiano, C., Reggio, R., Lillo, F., Mariani, A., Forcignano, F., Volpe, M., D'Avino, M., Yildirim, E., Yildirim, R., Bongiorni, M. G., Severi, S., Capucci, A., Lodigiani, C., Salomone, E., Serviddio, G., Tondo, C., Golino, P., Mazzone, C., Iacopino, S., Pengo, V, Galvani, M., Moretti, L., Ambrosino, P., Banfi, E., Biagioli, V, Bianchi, A., Boggian, G., Breschi, M., Brusorio, S., Ball, K., Calcagnoli, F., Campagna, G., Page, M., Renom, R., Jimeno Besa, B., Carpenedo, M., Ciabatta, C., Ciliberti, G., Kis, E., Cimmino, G., Ramos Gonzalez, M., Vieira Torres, L. G., Sucu, M., Chattranukulchai, P., Cho, J-G, D'Arienzo, C., Di Gennaro, L., Fedele, M., Ferrini, P. M., Jerzewski, A., Gorrebeeck, K., Geerlings, F., Dols, S., Debordes, M., de Graauw, J., De Graaf, J., Granzow, K., Danse, I, Bruin, S., Bosschaert, M., Bosman, F., Boersma-Slootweg, M., Boersma, L. V. A., Buiks, C., Terpstra, W., Groenemeijer, B. E., Nagibovich, O., Hermans, W., Guazzaloca, G., Hoogslag, P. A. M., Nierop, P. R., Guerra, F., The, S. H. K., Adriaansen, H., Lucassen, A., Lochorn, G., Herrman, J-P, Guldener, C., Pieterse, M. G. C., Bongaerts, M., Klomps, H., Ruiter, J. H., ten Cate, H., Zecca, C., Villani, R., Sottilota, G., Segreti, L., Scarone, C., Scaccianoce, A., Salomone, L., Rangel, G., Oriana, V, Occhilupo, P., Poeta, E. Mollica, Mesolella, E., Macellari, F., Longo, S., Lo Buglio, A., Tao, G. Z., Rosenqvist, Marten, Kasala, L., Oto, Ali, He, X. A., Zhou, B., Vinolas, Xavier, Kakkar, Ajay K., Fitzmaurice, David A., Fox, Keith A. A., Kayani, Gloria, Virdone, Saverio, Camm, A. John, and Pieper, Karen S.
- Subjects
medicine.medical_specialty ,business.industry ,Systemic embolism ,Atrial fibrillation ,Newly diagnosed ,Meth ,ta3121 ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Physiology (medical) ,Internal medicine ,Antithrombotic ,Cardiology ,Medicine ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,Major bleeding - Abstract
Background: Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. Methods: We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their relation to the time after diagnosis of atrial fibrillation in 52 014 patients prospectively enrolled in the GARFIELD-AF registry (Global Anticoagulant Registry in the FIELD–Atrial Fibrillation) between March 2010 and August 2016. Results: Over 12 months, 2140 patients died (mortality rate, 4.3; 95% CI, 4.2–4.5 per 100 person-years), of whom 288 (13.5%) died in the first month (6.8; 95% CI, 6.1–7.6). Over 12 months, 657 patients had a stroke/systemic embolism (1.3; 95% CI, 1.2–1.4) and 411 had a major bleeding (0.8; 95% CI, 0.8–0.9). During the first month, the rates (per 100 person-years) of stroke/systemic embolism and major bleed were 2.3 (95% CI, 1.9–2.8) and 1.5 (95% CI, 1.2–1.9), respectively. The elevated 1-month mortality rate was mostly attributable to cardiovascular mortality (3.5; 95% CI, 3.0–4.1), in particular, heart failure, sudden death, and acute coronary syndromes (1.0 [95% CI, 0.8–1.4], 0.6 [95% CI, 0.4–0.8], and 0.5 [95% CI, 0.3–0.8], respectively). Age, heart failure, prior stroke, history of cirrhosis, vascular disease, moderate-to-severe kidney disease, diabetes mellitus, and living in North or Latin America were independent predictors of a higher risk of early death, whereas anticoagulation and living in Europe or Asia were independent predictors of a lower risk of early death. A predictive model developed for the 1-month risk of death had a C-statistic of 0.81 (95% CI, 0.78–0.83). Conclusions: The increased hazard of early events, in particular, cardiovascular mortality, in newly diagnosed atrial fibrillation points to the importance of comprehensive care for such patients and should alert clinicians to detect warning signs of possible early mortality. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01090362.
- Published
- 2019
41. Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan ― Insights From GARFIELD-AF ―
- Author
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Kolesova, T., Yilmaz, MEHMET BİRHAN, Kakkar, Ajay K., Allu, Jagan, Worthy, V., Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Minardo, J., Merritt, D., Merliss, A., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Johnson, K., Jasinski, S., Hicks, T., Herrick, C., Henson, L., Headlee, M., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Gentry, P., Fielder, D., Ferdinand, K., Felpel, S., Evans, L., Eley, M., Dickerson, A., DePauw, J., Congal, S., Cervellione, K., Cassidy, D., Canova, M., Browne, A., Brown, A., Bowers, S., Bentley, M., Bartlett, M., Ball, K., Asafu-Adjaye, N., Treasure, C., Nishijima, D., Pitta, S., Duffy, P., Noveck, H., Ison, R., Alberts, M., Remmel, K., Theodoro, D., Diercks, D., Delafontaine, P., Ahmed, W., Reddy, R., Haque, I., Gutowski, T., Alfieri, A., Sharma, N., Beach, S., Miller, S., Williams, M., Mendelson, R., Falkowski, S., Franco, M., Cox, M., Kutayli, W. M., Ferrick, K., Quick, A., Wilson, V., Mullen, P., Garcia, J., Blumberg, E., Rama, P., Canosa, R., Goldhaber, S. Z., Thanzeel, M., Sharma, R., Mohamed, R., Maqsood, I., Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V., Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Hines, C., Haveman, K., Gulliver, W., Grenier, M. -C., Fox, B., Fournier, D., Ferleyko, L., Fearon, A., Farquhar, D., Ewert, A., Dunnigan, J., Douglass, S., Djaidani, Z., Denis, I., Dehghani, P., Daheb, S., Cleveland, T., Clarke, B., Carroll, L., Burke, E., Breakwell, L., Bignell, N., Bigcanoe, J., Bergeron, C., Beaudry, K., Aves, T., Aro, L., Angaran, P., Ahmad, K., Bonet, J., Ramjattan, B., Cha, J., Lavoie, A., Parkash, R., Fikry, S., Vizel, S., MacDonald, P., Coutu, B., Schweitzer, B., Hruczkowski, T., Dhillon, R., Dresser, G., Nadeau, R., Du Preez, M., Poirier, G., Heath, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V., Orosco, C., Mooso, B., Berlingieri, J., Ayala-Paredes, F., Beaudry, P., Leader, R., Cheung, S., Pandey, A. 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N., Pontoriero, J., Perez Prados, G., Novas, V., Navarro, A., Munguia, R., Meirino, A., Mautner, B., Matkovich, J., Martinelli, C., Martinelli, A., Maffei, L., Maehara, G., Lopez, A., Ingratta, M., Hrabar, A. D., Hansen, V., Tsuji, T., Tsuchiya, Y., Toru, S., Tohyo, S., Teragawa, H., Taya, K., Tanabe, G., Tana, T., Takenaka, K., Takei, K., Takeda, H., Take, S., Takanaka, C., Takai, H., Takahashi, S., Takahashi, K., Takagi, Y., Takagi, T., Taguchi, A., Tada, M., Ogawa, T., Nozoe, M., Nomura, S., Niwa, I., Nishizawa, K., Nishioka, H., Nishino, K., Nishihata, Y., Nishida, Y., Niinuma, H., Niijima, Y., Nariyama, J., Nanke, T., Nakazato, R., Nakayama, T., Nakanishi, N., Nakamura, R., Nakamura, M., Nakahara, S., Nakagomi, A., Nagata, H., Nagata, E., Nagai, S. (Shunichi), Nagai, S. (Sho), Murai, O., Morishita, K., Moriai, O., Mori, T., Mizuno, A., Mizuguchi, I., Miyata, S., Miyashita, A., Miyamoto, H., Miyajima, S., Miyaguchi, S., Miura, N., Mitsuhashi, H., Mineoi, K., Matsuura, Y., Matsushita, K., Matsui, S., Maruyama, Y., Maeda, K., Maeda, I., Kumazaki, T., Kumai, Y., Kozuka, T., Kotani, T., Koshibu, Y., Komatsu, I., Komatsu, H., Kojima, J., Koeda, T., Kobayashi, T., Kito, T., Kitazumi, H., Kitazawa, H., Kira, T., Kawano, S., Kawamoto, T., Kawakami, S., Kawakami, K., Kawai, K., Kawada, Y., Kato, Y., Kato, T., Kasai, T., Kano, H., Kaneko, M., Kanda, H., Kanai, H., Kamata, J., Kakuda, H., Iwase, T., Ito, N., Inoue, T., Inaba, H., Imaizumi, M., Ikeoka, K., Ikeda, K., Ikeda, H., Iiji, O., Ido, T., Horie, H. (Hideki), Honda, M., Hirota, S., Hirose, M., Hirayama, H., Hirasawa, K., Higuchi, K., Hayashi, Y., Hatsuno, T., Hasegawa, K., Hanazono, N., Hamaoka, M., Goto, T., Furumoto, W., Furukawa, T., Furukawa, N., Fukui, T., Fukuda, T., Fujisawa, Y., Fujisawa, A., Fujii, Y., Endo, M., Emura, Y., Doiuchi, J., Betsuyaku, T., Baba, T., Azuma, J., Asano, T., Asano, H., Arino, T., Aoyama, T., Aoki, K., Amano, T., Akahane, K., Adachi, T., Adachi, S. (Susumu), Adachi, S. (Sen), Abe, Y., Nagasaka, S., Okuda, F., Mukawa, H., Wada, M., Minagawa, T., Ishiguro, M., Mizuguchi, M., Yoshida, T. (Tomoki), Fujiura, Y., Kawano, Y., Abe, M., Mizuno, Y., Kanamori, S., Mori, E., Shirakawa, K., Ishioka, N., Noguchi, H., Nobuhito, Y., Shiga, Y., Toyota, F., Nakamura, T., Nakamura, Y., Okamoto, Y., Miyoshi, H., Shinohara, H., Shigekiyo, M., Miyamoto, Y., Ota, A., Okada, M., Yoshida, T., Iseki, F., Katsuya, T., Shindo, T., Suzuki, S., Shiraiwa, T., Ono, T., Otaki, E., Sato, K., Saito, K., Suzuki, K., Kodera, K., Pearce, Onuki Y., Sezaki, K., Ubukata, S., Honzawa, T., Sasaki, T., Seta, Y., Saito, Y., Oriuchi, T., Suzuki, Y., Suzuki, S. (Susumu), Suzuki, S. (Shunji), Suzuki, S. (Shu), Suzuki, K. (Keita), Suzuki, K. (Kazuo), Sugimoto, C., Suga, T., Shozawa, Y., Shirai, T., Shinozuka, T., Shinohe, R., Shimoyama, Y., Shimono, H., Shiina, Y., Shibata, N., Sekine, Y., Seki, S., Sawano, M., Sato, K. (Kiyoharu), Sato, K. (Kazuki), Sasaki, A., Sasaguri, H., Sasagawa, Y., Samejima, Y., Sakamoto, Y., Sakamoto, N., Sakai, H., Oriso, S., Pearce, Y. Onuki, Ono, H., Okuyama, M., Okita, H., Okamoto, K., Ohara, N., Misumi, I., Shah, S., Purayil, M. Padinhare, Pothiwala, R. A., Chandwani, P., Kulkarni, G., Kishore, R., Chopda, M., Roy, D., Srinivas, A., Sarma, R., Bhargava, K., Rajput, R. K., Shankar, A. G. Ravi, Durgaprasad, R., Jadhav, P., Sawhney, J. P. S., Kakkar, S., Zhu, X. Y., Zhou, Z. H., Zhou, B., Zheng, W. Y., Zhang, Y., Zhang, R., Zhang, Q., Zhang, G. S., Zhan, Q., Zhai, H., Yu, T., Yu, J. H., Yu, H. Y., Ye, Y., Yang, Y. J., Yang, Q., Yang, L. L., Yang, J. S., Xu, R. Y., Xie, Q., Wu, R. N., Wang, L., Wang, K., Tian, G., Sun, Y. H., Shi, X. J., Sheng, X., Peng, J. Q., Ma, T. Y., Luo, X. L., Lu, Z. C., Liu, Y. Y., Liu, W. L., Liu, T. T., Li, Y. H., Li, L., Li, J., Li, B., Huang, X. F., Hu, X. S., He, X. A., He, R. H., Guo, W. N., Gao, X. J., Fu, Q. H., Feng, S., Chen, X., Chen, J. Y., Chen, J., Bai, C. L., Yang, Z. M., Wang, F. Z., Xue, L., Guo, Y., Jiao, Y., Chen, P., Xiong, L. G., Chen, M. S., Zhao, R. P., Yan, X. W., Cheng, X. S., Wu, T. G., Li, X., Wang, Y. ( Yong), Wang, Y. (Ying), He, S. H., Chen, Y. M., Yang, P., Tao, G. Z., Yin, Y. H., Li, W. H., Wang, D. W., Cao, S. P., Chen, J. Z., Zhang, H. Q., Zhao, Y. S., Chen, K. N., Hu, D. Y., Fitzmaurice, David, Al Mahmeed, Wael, Parkhomenko, Alex, Oto, Ali, Angchaisuksiri, Pantep, Steffel, Jan, Rosenqvist, Marten, Vinolas, Xavier, Oh, Seil, Jacobson, Barry, Lim, Toon Wei, Panchenko, Elizaveta, Stepinska, Janina, Atar, Dan, Ten Cate, Hugo, Sanchez Diaz, Carlos Jerjes, Koretsune, Yukihiro, Ambrosio, Giuseppe, Agnelli, Giancarlo, Sawhney, Jitendra Pal Singh, Kakkar, Sanjay, Keltai, Matyas, Darius, Harald, Le Heuzey, Jean-Yves, Raatikainen, Pekka, Ragy, Hany, Nielsen, Jorn Dalsgaard, Jansky, Petr, Hu, Dayi, Corbalan, Ramon, Eikelboom, John, Spyropoulos, Alex, Connolly, Stuart J., Pereira Barretto, Antonio Carlos, Cools, Frank, Brodmann, Marianne, Gibbs, Harry, Lucas Luciardi, Hector, Oda, H., Sato, A., Fujimoto, S., Tsubokura, T., Goda, T., Maeda, I, Takamura, I, Agata, J., Yokota, Naoto, Ando, Shin-ichi, Shibuya, Mitsuhiro, Eshima, Kenichi, Sakuma, Ichiro, Kumeda, Kenshi, Suetsugu, Tetsuro, Katsuda, Yousuke, Etoh, Takuma, Abu-Mahfouz, M., Sadamatsu, K., Katsuda, Y., Kumagai, K., Koretsune, Y., Panse, S. G., Vanajakshamma, V., Suresh, S., Singhal, S., Shiva, P., Sharma, M., Sadhu, N., Rao, N. M., Rao, M., Prashanth, K., Naik, D., More, P., Meena, R., Madarkar, N., Lokesh, B., Lawande, A., Krishnappa, S., Kaur, S., Kasala, L., Karthikeyan, R., Jain, V., Giradkar, S., Ganatra, A., Earath, M., Duhan, S., Dhyani, V., Dhakrao, P., Deshpande, B., Davies, D., Dargude, M., Bhattacharjee, P., Begum, H., Barai, A., Adak, D., Abraham, S., Jain, D., Kumar, S., Gupta, J. B., Khan, A., Bisne, V., Bantwal, G., Vijan, V. M., Vijayaraghavan, G., Raghuraman, B., Kothiwale, V. A., Chawla, K., Inagaki, K., Anno, T., Iseki, A., Horie, H., Narumi, J., Owari, M., Mizuguchi, I, Furukawa, Y., Matsumoto, N., Dorian, P., Tarrant, J., Cameron-Watts, J., Hegde, M. P., Dumikyan, A., Figura-Chmielewska, M., Alborough, E., Sabir, A., Reimer, D., Hergdt, G., Nierop, P. R., Baglioni, G., Viana, T., Vargas, T., Ely Pizzato, P., Drummond Wainstein, A. P., Ikitimur, B., Genc, D., Yoshida, T. (Tetsuro), Nagamalesh, U. M., Ishihara, A., Fu, G. S., Fox, Keith A. A., Flint, K., and Roesch, H.
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,Embolism ,Administration, Oral ,Hemorrhage ,Newly diagnosed ,030204 cardiovascular system & hematology ,Risk Assessment ,Risk profile ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Registries ,Stroke ,Aged ,Aged, 80 and over ,Fibrillation ,business.industry ,Anticoagulant ,Anticoagulants ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Stroke prevention ,Cohort ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Platelet Aggregation Inhibitors ,030217 neurology & neurosurgery - Abstract
Background Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke prevention in patients with newly diagnosed non-valvular AF (NAVF) that is being conducted in 35 countries. Methods and Results: A total of 52,081 patients with a new diagnosis of NVAF were enrolled prospectively in GARFIELD-AF. Of these, 4859 (9.3%) were recruited in Japan (2010-2016). In cohort 1 (2010-2011), few patients were on non-vitamin K antagonist oral anticoagulants (NOAC) globally. From cohort 2 onwards (2011-2016), however, there was a rapid increase in NOAC use around the globe, especially in Japan. By the last year of enrolment (2015-2016), 67.9% of patients in Japan and 43.1% of patients globally were on NOAC±antiplatelet therapy (AP). In Japan and globally, 17.0% and 12.2% of patients, respectively, did not receive stroke prevention treatment. Few patients in Japan (5.7%) received AP only. Compared with the other countries, the unadjusted rates of all-cause mortality and major bleeding were low, while rates of stroke/systemic embolism were similar after 1 year of follow-up. Conclusions GARFIELD-AF continues to provide important information on the homogeneity and heterogeneity of baseline characteristics and treatment patterns in patients with newly diagnosed NVAF. This diversity reflects the differences in outcomes in Japan compared with the rest of the world.
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- 2018
42. Effect of operator and institutional volume on clinical outcomes after percutaneous coronary interventions performed in Canada and the United States: A brief report from the Enhanced Suppression of the Platelet glycoprotein IIb/IIIa Receptor with Integrilin Therapy (ESPRIT) study
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Madan, Mina, Nikhil, Janarthan, Hellkamp, Anne S., Pieper, Karen S., Labinaz, Marino, Cohen, E.A., Buller, Christopher E., Cantor, Warren J., Seidelin, Peter, Ducas, John, Carere, Ronald G., Natarajan, Madhu K., Conor O'Shea, J., and Tcheng, James E.
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- 2009
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43. Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study
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Becker, Richard C, Moliterno, David J, Jennings, Lisa K, Pieper, Karen S, Pei, Jinglan, Niederman, Alan, Ziada, Khaled M, Berman, Gail, Strony, John, Joseph, Diane, Mahaffey, Kenneth W, Van de Werf, Frans, Veltri, Enrico, and Harrington, Robert A
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- 2009
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44. Predictors of 30-day mortality in patients with refractory cardiogenic shock following acute myocardial infarction despite a patent infarct artery
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Katz, Jason N., Stebbins, Amanda L., Alexander, John H., Reynolds, Harmony R., Pieper, Karen S., Ruzyllo, Witold, Werdan, Karl, Geppert, Alexander, Dzavik, Vladimir, Van de Werf, Frans, and Hochman, Judith S.
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- 2009
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45. Validity of a risk-prediction tool for hospital mortality: The Global Registry of Acute Coronary Events
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Pieper, Karen S., Gore, Joel M., FitzGerald, Gordon, Granger, Christopher B., Goldberg, Robert J., Steg, Gabriel, Eagle, Kim A., Anderson, Frederick A., Budaj, Andrzej, and Fox, Keith A.A.
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- 2009
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46. Comparison of Site-Reported and Core Laboratory-Reported Creatine Kinase-MB Values in Non–ST-Segment Elevation Acute Coronary Syndrome (from the International Trial SYNERGY)
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Linefsky, Jason P., Lin, Min, Pieper, Karen S., Reist, Craig J., Berdan, Lisa G., Antman, Elliott M., Goodman, Shaun G., French, John K., Guneri, Sema, Roe, Matthew T., Newby, L. Kristin, Harrington, Robert A., Ferguson, James J., Califf, Robert M., and Mahaffey, Kenneth W.
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- 2009
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47. Extent, Location, and Clinical Significance of Non–Infarct-Related Coronary Artery Disease Among Patients With ST-Elevation Myocardial Infarction
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Park, Duk-Woo, Clare, Robert M., Schulte, Phillip J., Pieper, Karen S., Shaw, Linda K., Califf, Robert M., Ohman, Magnus E., Van de Werf, Frans, Hirji, Sameer, Harrington, Robert A., Armstrong, Paul W., Granger, Christopher B., Jeong, Myung-Ho, and Patel, Manesh R.
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- 2014
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48. Cardioversion in patients with newly diagnosed non-valvular atrial fibrillation: Observational study using prospectively collected registry data
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Pope, Marita Knudsen, Hall, Trygve S, Schirripa, Valentina, Radic, Petra, Virdone, Saverio, Pieper, Karen S, Le Heuzey, Jean-Yves, Jansky, Petr, Fitzmaurice, David A, Cappato, Riccardo, Atar, Dan, Camm, A John, Kakkar, Ajay K, Bassand, Jean-Pierre, Fox, Keith A A, Gersh, Bernard J, Goldhaber, Samuel Z, Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G, Misselwitz, Frank, Turpie, Alexander G G, van Eickels, Martin, Verheugt, Freek W A, Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J, Eikelboom, John, Corbalan, Ramon, Jing, Zhi-Cheng, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Darius, Harald, Keltai, Matyas, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Sánchez Díaz, Carlos Jerjes, Ten Cate, Hugo, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Hu, Dayi, Chen, Kangning, Zhao, Yusheng, Zhang, Huaiqin, Chen, Jiyan, Cao, Shiping, Wang, Daowen, Yang, Yuejin, Li, Weihua, Li, Hui, Yin, Yuehui, Tao, Guizhou, Yang, Ping, Chen, Yingmin, He, Shenghu, Wang, Yong, Fu, Guosheng, Li, Xin, Wu, Tongguo, Cheng, Xiaoshu, Yan, Xiaowei, Zhao, Ruiping, Chen, Moshui, Xiong, Longgen, Chen, Ping, Jiao, Yang, Guo, Ying, Xue, Li, Yang, Zhiming, Jadhavm, Praveen, Sarma, Raghava, Kulkarni, Govind, Chandwani, Prakash, Pothiwala, Rasesh Atulbhai, Purayil, Mohanan Padinhare, Chawla, Kamaldeep, Kothiwale, Veerappa Annasaheb, Raghuraman, Bagirath, Vijan, Vinod Madan, Sawhney, Jitendra, Bantwal, Ganapathi, Khan, Aziz, Meena, Ramdhan, Chopada, Manojkumar, Abraham, Sunitha, Bisne, Vikas, Vijayaraghavan, Govindan, Roy, Debabrata, Durgaprasad, Rajashekhar, Shankar, A G Ravi, Kumar, Sunil, Jain, Dinesh, Bhargava, Kartikeya, Kumar, Vinay, Nagamalesh, Udigala Madappa, Rajput, Rajeeve Kumar, Kanamori, Seishu, Yamamoto, Kenichi, Kumagai, Koichiro, Katsuda, Yosuke, Yoshida, Keiki, Toyota, Fumitoshi, Mizuno, Yuji, Misumi, Ikuo, Noguchi, Hiroo, Ando, Shinichi, Suetsugu, Tetsuro, Minamoto, Masahiro, Oda, Hiroyuki, Adachi, Susumu, Chiba, Kei, Norita, Hiroaki, Tsuruta, Makoto, Koyanagi, Takeshi, Yamamoto, Kunihiko, Ando, Hiroshi, Higashi, Takayuki, Okada, Megumi, Azakami, Shiro, Komaki, Shinichiro, Kumeda, Kenshi, Murayama, Takashi, Matsumura, Jun, Oba, Yurika, Sonoda, Ryuji, Goto, Kazuo, Minoda, Kotaro, Haraguchi, Yoshikuni, Suefuji, Hisakazu, Miyagi, Hiroo, Kato, Hitoshi, Nakamura, Tsugihiro, Nakamura, Tadashi, Nandate, Hidekazu, Zaitsu, Ryuji, Fujiura, Yoshihisa, Yoshimura, Akira, Numata, Hiroyuki, Ogawa, Jun, Kamogawa, Yasuyuki, Murakami, Kinshiro, Wakasa, Yutaka, Yamasawa, Masanori, Maekawa, Hiromitsu, Abe, Sumihisa, Kihara, Hajime, Tsunoda, Satoru, Saito, Katsumi, Tachibana, Hiroki, Oba, Ichiro, Kuwahata, Takashi, Higa, Satoshi, Gushiken, Masamichi, Eto, Takuma, Chibana, Hidetoshi, Fujisawa, Kazuaki, Shiga, Yuhei, Sumi, Hirokuni, Nagatomo, Toshihisa, Atsuchi, Yoshihiko, Nagoshi, Toshiro, Sanno, Kazuhisa, Hoshino, Fumihiro, Yokota, Naoto, Kameko, Masahiro, Tabuchi, Toshifumi, Ishizawa, Munesumi, Fujiura, Yoshitake, Ikeda, Daisuke, Seto, Taku, Iwao, Tetsu, Ishioka, Norio, Oshiro, Koichi, Tsuchida, Keizo, Hatori, Yutaka, Takeuchi, Motoshi, Takezawa, Hiroto, Nagano, Shinjiro, Iwaki, Masaaki, Nakamura, Yuichiro, Miyamoto, Naomasa, Taguchi, Toshifumi, Ashida, Ko, Yoshizawa, Naoto, Agata, Jun, Matsukawa, Seishiro, Arasaki, Osamu, Fukuoka, Shuji, Murakami, Hirofumi, Mishima, Kazuya, Hata, Yoshiki, Sakuma, Ichiro, Obunai, Kotaro, Takamura, Ichiro, Akutsu, Mitsuyuki, Unoki, Toshihide, Go, Yoshinori, Ikemura, Makoto, Morii, Shoji, Marusaki, Shigeru, Doi, Hideo, Tanaka, Mitsuru, Kusumoto, Takaaki, Kakinoki, Shigeo, Ogurusu, Chiga, Murata, Kazuya, Shimoyama, Masaki, Nakatsuka, Masami, Kitami, Yutaka, Nakamura, Yoichi, Oda, Hiroshi, Oyama, Rikimaru, Ageta, Masato, Mita, Teruaki, Nagao, Kazuhiko, Mito, Takafumi, Minami, Junichi, Abe, Mitsunori, Fujii, Masako, Okawa, Makoto, Fujito, Tsuneo, Taniguchi, Toshiya, Ko, Tenei, Kubo, Hiroshi, Imamaki, Mizuho, Akiyama, Masahiro, Ueda, Takashi, Odakura, Hironori, Inagaki, Masahiko, Katsube, Yoshiki, Nakata, Atsuyuki, Tomimoto, Shinobu, Shibuya, Mitsuhiro, Nakano, Masayuki, Ito, Kenichiro, Matsuta, Masahiro, Ishiguro, Motoyuki, Minagawa, Taro, Wada, Masamichi, Mukawa, Hiroaki, Mizuguchi, Masato, Okuda, Fumio, Kimura, Teruaki, Taga, Kuniaki, Techigawara, Masaaki, Igarashi, Morio, Watanabe, Hiroshi, Seo, Toshihiko, Hiramitsu, Shinya, Hosokawa, Hiroaki, Hoshiai, Mitsumoto, Hibino, Michitaka, Miyagawa, Koichi, Horie, Hideki, Sugishita, Nobuyoshi, Shiga, Yukio, Soma, Akira, Neya, Kazuo, Yoshida, Tetsuro, Akahane, Kunio, Adachi, Sen, Takanaka, Chiei, Matsui, Saori, Kanda, Hirofumi, Kaneko, Masanori, Nagasaka, Shiro, Taguchi, Atsushi, Toru, Shuta, Saito, Kazuyuki, Miyashita, Akiko, Sasaguri, Hiroki, Nariyama, Jin, Hatsuno, Taketo, Iwase, Takash, Sato, Kazuki, Kawai, Kazuya, Kotani, Tomobumi, Tsuji, Tsuyoshi, Sakai, Hirosumi, Nishino, Kiyoshi, Ikeda, Kenichi, Maeda, Kazuo, Shinozuka, Tomohiro, Inoue, Takeshi, Kawakami, Koichi, Kitazumi, Hiromichi, Takagi, Tsutomu, Hamaoka, Mamoru, Kojima, Jisho, Sasaki, Akitoshi, Tsuchiya, Yoshihiro, Betsuyaku, Tetsuo, Higuchi, Koji, Honda, Masaaki, Hasegawa, Koichi, Baba, Takao, Mineoi, Kazuaki, Koeda, Toshihiko, Hirasawa, Kunihiko, Kumazaki, Toshihide, Nakagomi, Akira, Otaki, Eiji, Shindo, Takashi, Hirayama, Hiroyoshi, Sugimoto, Chikako, Yamagishi, Takashi, Mizuguchi, Ichiro, Sezaki, Kazunori, Niwa, Isamu, Takenaka, Ken, Iiji, Osamu, Taya, Koichi, Kitazawa, Hitoshi, Ueda, Samu, Kakuda, Hirokazu, Ono, Takuya, Oriso, Seizo, Kamata, Junya, Nanke, Toshihiko, Maeda, Itaru, Matsuura, Yoshifusa, Teragawa, Hiroki, Maruyama, Yasuyuki, Takei, Kazuo, Horie, Hajime, Kito, Tetsutaro, Asano, Hiroshi, Matsushita, Koji, Nakamura, Masaichi, Washizuka, Takashi, Yoshida, Tomoki, Sawano, Masato, Arima, Shinichi, Arai, Hidekazu, Shinohara, Hisanori, Takai, Hiroyuki, Furukawa, Nobufusa, Ota, Akira, Yamamoto, Kentaro, Aoki, Kenji, Yamamoto, Taku, Kasai, Takeaki, Suzuki, Shunji, Suzuki, Shu, Shibata, Nitaro, Watanabe, Masayuki, Nishihata, Yosuke, Arino, Toru, Okuyama, Masaki, Wakiyama, Tetsushi, Kato, Tomoko, Sasagawa, Yasuo, Tana, Takeshi, Hayashi, Yoshihito, Hirota, Shinichi, Abe, Yukihiko, Saito, Yoshihiro, Uchiyama, Hirohide, Takeda, Hiroshi, Ono, Hiroshi, Tohyo, Shuichi, Hanazono, Naoto, Miyajima, Seiichi, Shimono, Hisashi, Aoyama, Takuma, Shozawa, Yasunobu, Niijima, Yawara, Murai, Osamu, Inaba, Hideko, Nomura, Katsumasa, Nozoe, Masatsugu, Suzuki, Kazuo, Furukawa, Toshiyuki, Shiraiwa, Toshihiko, Ito, Nobuhisa, Nagai, Shunichi, Sato, Kiyoharu, Nakahara, Shiro, Shimoyama, Yujin, Ohara, Naoko, Kozuka, Teruhiko, Okita, Hideaki, Endo, Masato, Goto, Tsutomu, Hirose, Makoto, Nagata, Emiko, Nakanishi, Noriyuki, Mori, Toshizumi, Seki, Shuichi, Okamoto, Katsuhiro, Moriai, Osamu, Emura, Yoko, Fukuda, Tsuyoshi, Date, Haruhiko, Kawakami, Shuichi, Nagai, Sho, Ueyama, Yuya, Fudo, Tetsuro, Imaizumi, Mitsuru, Ogawa, Takuo, Take, Shunsuke, Ikeda, Hideo, Nishioka, Hiroaki, Sakamoto, Norihiko, Ikeoka, Kiyomitsu, Wakaki, Nobuo, Abe, Masatake, Doiuchi, Junji, Kira, Tetsuya, Tada, Masato, Tsuzaki, Ken, Miura, Naoya, Fujisawa, Yasuaki, Furumoto, Wataru, Suzuki, Susumu, Fujisawa, Akinori, Nakamura, Ryosai, Komatsu, Hiroyasu, Fujiki, Rei, Kawano, Shuichi, Nishizawa, Keijiro, Kato, Yoji, Azuma, Junya, Yasui, Kiyoshi, Amano, Toshio, Sekine, Yasuhiro, Honzawa, Tatsuo, Koshibu, Yuichiro, Sakamoto, Yasuhide, Seta, Yukihiro, Miyaguchi, Shingo, Morishita, Kojuro, Samejima, Yasuko, Sasaki, Toyoshi, Iseki, Fumiko, Kobayashi, Toshiyuki, Kano, Hiroshi, Kim, Jaeyoung, Yamaguchi, Hiroshi, Takagi, Yoichi, Pearce, Yoko Onuki, Suzuki, Yasuyuki, Fukui, Takayuki, Nakayama, Toru, Kanai, Hideaki, Kawano, Yoshiyuki, Ino, Tetsuji, Miyoshi, Hironori, Miyamoto, Yasufumi, Shigekiyo, Masahito, Ono, Shimato, Okamoto, Yutaka, Ubukata, Satoshi, Kodera, Kojiro, Oriuchi, Tatsuo, Matsumoto, Naoki, Inagaki, Koichi, Iseki, Atsushi, Yoshida, Tomohiro, Goda, Toshihiro, Katsuki, Tsukasa, Sato, Atsushi, Mori, Etsuo, Tsubokura, Toshio, Shudo, Hiroshi, Fujimoto, Shunichi, Katsuya, Tomohiro, Furukawa, Yoshiyuki, Hosokawa, Hiroshi, Narumi, Jun, Yamamoto, Kiichiro, Owari, Masaki, Inakura, Takuya, Anno, Takafumi, Shirakawa, Kazuyuki, Ching, Chi Keong, Foo, David, Wong, Kelvin, Yuyang, Tan, Park, Hui Nam, Kim, Woo-Shik, Lee, HyeYoung, Jang, Sung-Won, Kim, Dae Hyeok, Kim, Jun, Ryu, DongRyeol, Shim, Jaemin, Kim, Dae-Kyeong, Choi, Dong Ju, Oh, Yong Seog, Cho, Myeong-Chan, Kim, Hack-Lyoung, Jeon, Hui-Kyung, Shin, Dong-Gu, Park, Sang Weon, Park, Hoon Ki, Han, Sang-Jin, Sung, Jung Hoon, Park, Hyung-Wook, Nam, Gi-Byoung, On, Young Keun, Lim, Hong Euy, Kwak, JaeJin, Cha, Tae-Joon, Hong, Taek Jong, Park, Seong Hoon, Yoon, Jung Han, Kim, Nam-Ho, Kim, Kee-Sik, Jung, Byung Chun, Hwang, Gyo-Seung, Kim, Chong-Jin, Rungaramsin, Sakda, Katekangplu, Peerapat, Khunrong, Porames, Bunyapipat, Thanita, Wongcharoen, Wanwarang, Kaewsuwanna, Pinij, Siriwattana, Khanchai, Tiyanon, Waraporn, Pattanaprichakul, Supalerk, Likittanasombat, Khanchit, Cholsaringkarl, Doungrat, Boonyapisit, Warangkana, Cheewatanakornkul, Sirichai, Silaruks, Songkwan, Hutayanon, Pisit, Chawanadelert, Seksan, Chattranukulchai, Pairoj, Chatlaong, Boonsert, Santanakorn, Yingsak, Kanokphatcharakun, Khompiya, Mongkolwongroj, Piya, Jai-Aue, Sasivimon, Komson, Ongkarn, Altun, Armagan, Aydinlar, Ali, Topsakal, Ramazan, Ongen, Zeki, Acikel, Sadik, Sahin, Durmus Yildiray, Yilmaz, Ozcan, Yilmaz, Mehmet Birhan, Pekdemir, Hasan, Demir, Mesut, Sucu, Murat, Sahiner, Levent, Ersanli, Murat, Okuyan, Ertugrul, Aras, Dursun, Rolandi, Florencia, Ingaramo, Adrian Cesar, Sambadaro, Gustavo Alberto, Caputi, Vanina Fernandez, Luciardi, Hector, Berman, Sofia Graciela, Dragotto, Pablo, Kleiban, Andres Javier, Centurion, Nestor, 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Muñoz, Ernesto Cardona, Hernandez, Norberto Matadamas, Rendon, Adolfo Leyva, Hernandez, Norberto Garcia, de los Rios Ibarra, Manuel, Carrillo, Luis Ramon Virgen, Villezca, David Lopez, Herrera, Carlos Hernandez, Lopez Prieto, Juan Jose, Rodriguez, Rodolfo Gaona, Espinosa, Efrain Villeda, Martinez, David Flores, Barcena, Jose Velasco, Fierro, Omar Fierro, Briones, Ignacio Rodriguez, Leiva Pons, Jose Luis, Lopez, Humberto Alvarez, Ruiz, Rafael Olvera, Brito, Carlos Gerardo Cantu, Valenzuela, Eduardo Julian Jose Roberto Chuquiure, Sanchez, Roxana Reyes, Bazzoni Ruiz, Alberto Esteban, Lopez Ruiz, Oscar Martin, Nava, Roberto Arriaga, Morales Cerda, Jesus David, Campos, Pedro Fajardo, Gonzalez, Mario Benavides, Lenz, Kurt, Hagn, Claus, Foechterle, Johannes, Drexel, Heinz, Huber, Kurt, Podczeck-Schweighofer, Andrea, Winkler, Michael, Schneeweiss, Bruno, Gegenhuber, Alfons, Lang, Wilfried, Eichinger-Hasenauer, Sabine, Kaserer, Peter, Sykora, Josef, Rasch, Heribert, Strohmer, Bernhard, Capiau, 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Mertz, Jacob, Schou, Morten, Olsen, Michael, Airaksinen, K E Juhani, Paganelli, Franck, Ohayon, Joël, Casassus, Frédéric, Galinier, Michel, Gottwalles, Yannick, Loiselet, Philippe, Muller, Jean-Joseph, Koujan, Mohamed Bassel, Marquand, André, Destrac, Sylvain, Piot, Olivier, Delarche, Nicolas, Cebron, Jean-Pierre, Guenoun, Maxime, Guedj-Meynier, Dominique, Lokesh, A G, Zuber, Mathieu, Amarenco, Pierre, Ellie, Emmanuel, Kadouch, James, Fournier, Pierre-Yves, Huberman, Jean-Pierre, Lemaire, Nestor, Rodier, Gilles, Vandamme, Xavier, Sibon, Igor, Neau, Jean-Philippe, Mahagne, Marie Hélène, Mielot, Antoine, Bonnefoy, Marc, Churet, Jean-Baptiste, Navarre, Vincent, Sellem, Frederic, Monniot, Gilles, Boyes, Jean-Paul, Doucet, Bernard, Martelet, Michel, Obadia, Désiré, Crousillat, Bernard, Mouallem, Joseph, Bearez, Etienne, Brugnaux, Jean Philippe, Fedorowsky, Alain, Nazeyrollas, Pierre, Berneau, Jean-Baptiste, Chemin, Frédéric, Schellong, Sebastien, Koeniger, Georg, Kopf, Andreas, Gerbaulet, 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Mauro, Raisaro, Arturo, Fattore, Luciano, Mauric, Andrea, Germini, Fabrizio, Tedeschi, Luca, Settimi, Maria, Nicoli, Sergio, Ricciarini, Paolo, Argena, Antonio, Ronchini, Paolo, Bulla, Claudio, Tradati, Filippo, Volpe, Massimo, D’Avino, Maria, Bongiorni, Maria Grazia, Severi, Silva, Capucci, Alessandro, Lodigiani, Corrado, Salomone, Enrico, Serviddio, Gaetano, Tondo, Claudio, Golino, Paolo, Mazzone, Carmine, Iacopino, Saverio, ten Cate, Hugo, Ruiter, J H, Lucassen, Andreas, Adriaansen, Henk, Bongaerts, Maarten, Pieterse, Mathijs, van Guldener, Coen, Herrman, Johannes, Nierop, S H K P R, Hoogslag, Pieter, Hermans, Walter, Groenemeijer, B E, Terpstra, W, Buiks, Cees, Boersma, L V A, Berge, Eivind, Sirnes, Per Anton, Gjertsen, Erik, Hole, Torstein, Erga, Knut, Hallaråker, Arne, Skjelvan, Gunnar, Østrem, Anders, Ghezai, Beraki, Svilaas, Arne, Christersson, Peter, Øien, Torbjørn, Henrichsen, Svein Høegh, Otterstad, Jan Erik, Berg-Johansen, Jan, Gieroba, Andrzej, Biedrzycka, Malgorzata, 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Bayo i Llibre, Joan, Vicente, Cecilia Corros, Gutierrez, Manuel Vida, Gonzalo, Francisco Epelde, Almeida Fernandez, Carlos Alexandre, Navarro, Encarnacion Martinez, Alia, Juan Jose Montero, Gonzalez, Maria Barreda, Oliva, Maria Angels Moleiro, Sanmartin, Jose Iglesias, Gonzalez, Mercedes Jimenez, Alvarez, Maria del Mar Rodriguez, Melenchon, Juan Herreros, Vera, Tomas Ripoll, Navarro, Manuel Jimenez, Caamano, Maria Vazquez, Arcocha Torres, Maria Fe, Gomez, Gonzalo Marcos, Romo, Andres Iniguez, Prieto Diaz, Miguel Angel, Rosenqvist, Mårten, Wirdby, Alexander, Lindén, Jan, Henriksson, Kerstin, Elmersson, Micael, Egilsson, Arnor, Börjesson, Ulf, Svärd, Gunnar, Liu, Bo, Lindh, Anders, Olsson, Lars-Bertil, Gustavsson, Mikael, Andersson, Lars, Benson, Lars, Bothin, Claes, Hajimirsadeghi, Ali, Martinsson, Björn, Ericsson, Marianne, Ohlsson, Åke, Lindvall, Håkan, Svensson, Peter, Thörne, Katarina, Händel, Hans, Platonov, Pyotr, Bernsten, Fredrik, Timberg, Ingar, Crisby, Milita, Karlsson, 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Wakeman, Anne, Stokes, Michael, Kirby, Graham, Vishwanathan, Bhaskhar, Bird, Nigel, Evans, Paul, Clark, M, Bisatt, John, Litchfield, Jennifer, Fisher, E, Fooks, Tim, Kelsall, Richard, Paul, Neil, Alborough, Elizabeth, Aziz, Michael, Ramesh, C, Wilson, Pete, Franklin, Simon, Fairhead, Sue, Thompson, Julian, Chowan, Hasan, Taylor, Gary, Tragen, Dawn, Parfitt, Matt, Seamark, Claire, Paul, Carolyn, Richardson, Mark, Jefferies, Angus, Sharp, Helen, Jones, Hywel, Giles, Claire, Bramley, Matthew, Williams, Philip, Aldegather, Jehad, Wetherell, Simon, Lumb, William, Evans, Phil, Scouller, Frances, Macey, Neil, Rogers, Stephen, Stipp, Yvette, West, Richard, Pinney, Philip, Wadeson, Paul, Matthews, John, Pandya, Preeti, Gallagher, Andrew, Railton, T, Davies, Emyr, McClure, Jonathan, Jacobs, Marc, Hutton, Claire, Thompson, R, Sinha, Bijoy, Butter, Keith, Barrow, Susan, Little, Helen, Russell, David, Choudhary, Ulka, Haq, Ikram, Ainsworth, Paul, Jones, Claire, Weeks, Phil, Eden, Jane, Gibbons, 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Mike, Pugsley, Mark, Dooldeniya, Chaminda, Rogers, Greg, Bennett, James, Jacobs, Polly, Muvva, Rajesh, Adam, Matthew, Fox, Robin, Thomas, Nicolas, Cartwright, Simon, Reed, Rory, Randfield, Simon, A’Court, Christine, Flynn, Ann, Halpin, Andrew, Dobson, Simon, Lomax, Louise, Nadaph, Minnal, Munro, Iain, Goram, Jane, Stoddart, Helen, Simmons, Phil, Shewring, John, Bowen-Simpkins, Emma, Rickenbach, Mark, Blenkhorn, Adam, Singh, Bhuwanendu, Astridge, Penny, van Gaal, William, Abhayaratna, Walter, Thomson, Philip, Lehman, Ron, Kilian, Jens, Coulshed, David, Catanchin, Andrei, Colquhoun, David, Kiat, Hosen, Eccleston, David, French, John, Ayres, Bronte, Blombery, Peter, Phan, Thanh, Rogers, James, O’Donnell, David, Bae, Sang Cheol, Carroll, Patrick, Starmer, Greg, Arstall, Margaret, Binnekamp, Maurits, Lee, Astin, Luton, Robert, Gupta, Milan, Pandey, Amritanshu Shekhar, Cheung, Stephen, Leader, Rolland, Beaudry, Philippe, Ayala-Paredes, Félix, Berlingieri, Joseph, Heath, John, Poirier, Germain, du Preez, Miranda, Schweitzer, Bradley, Nadeau, Reginald, Dhillon, Ripple, Hruczkowski, Tomasz, Lavoie, Andrea, Parkash, Ratika, Cha, James, Coutu, Benoit, MacDonald, Paul, Ramjattan, Brian, Bonet, Jorge, Vizel, Saul, Angaran, Paul, Fikry, Sameh, Mowafy, Ahmed, Katta, Azza, Tawfik, Mazen, Nawar, Moustafa, Sobhy, Mohamed, Abou Seif, Seif Kamal, Khairy, Tarek, El-Aziz, Ahmed Abd, Taha, Nasser, Reda, Ashraf, Elbahry, Atef, Setiha, Mohamed, El Din, Mohamed Gamal, Elkhadem, Magdi, El-Etreby, Adel, Kettles, David, Bayat, Junaid, Siebert, Heidi, Horak, Adrian, Kelfkens, Ynez, Garda, Riaz, Pillay, Thayabran, Guerra, Michele, van Zyl, Louis, Theron, Hendrik, Murray, Andrew, Louw, Rikus, Greyling, Deon, Mntla, Pindile, Ismail, Siddique, Ahmed, Fayzal, Engelbrecht, Johannes, Maharajh, Shambu, Oosthuysen, Wessel, Loghdey, Rehana, Ueckermann, Veronica, Al Naeemi, Abdullah, Yousef, Ghazi, Bazargani, Nooshin, AlOmairi, Munther, Maruthanayagam, Rajan, Singh, Rupesh, Naguib, Ahmed, Ibrahim, Mohamed, Agrawal, Amrish, Nathani, Mukesh, Esheiba, Ehab M, Wassef, Adel, Gupta, Rajeev, Cox, Michael, Beach, Scott, Duffy, Peter, Falkowski, Stephen, Ferrick, Kevin, Franco, Miguel, Kutayli, W Michael, Quick, Annette, Sharma, Niraj, Wilson, Vance, Miller, Stephen, Alberts, Mark, Blumberg, Edwin, Canosa, Roddy, Gutowski, Ted, Ison, Rodney, Garcia, Jorge, Mullen, Paul, Noveck, Howard, Rama, Pamela, Reddy, Rajneesh, Williams, Marcus, Nishijima, Daniel, Ferdinand, Keith, Haque, Ihsan, Mendelson, Robert, Pitta, Sridevi, Theodoro, Daniel, Treasure, Charles, Moustafa, Moustafa, Cader, Cas, Pharr, Walter, Oropallo, Alisha, Platt, George, Gujral, Jaspal, Welker, James, and Koura, Firas
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Electric Countershock ,Therapeutics ,Cardioversion ,Lower risk ,Cause of Death ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Prospective Studies ,Registries ,Propensity Score ,Stroke ,Aged ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Research ,Anticoagulant ,Hazard ratio ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Propensity score matching ,Cardiology ,Female ,business ,RC - Abstract
OBJECTIVE To investigate the clinical outcomes of patients who underwent cardioversion compared with those who did not have cardioverson in a large dataset of patients with recent onset non-valvular atrial fibrillation. DESIGN Observational study using prospectively collected registry data (Global Anticoagulant Registry in the FIELD-AF-GARFIELD-AF). SETTING 1317 participating sites in 35 countries. PARTICIPANTS 52 057 patients aged 18 years and older with newly diagnosed atrial fibrillation (up to six weeks' duration) and at least one investigator determined stroke risk factor. MAIN OUTCOME MEASURES Comparisons were made between patients who received cardioversion and those who had no cardioversion at baseline, and between patients who received direct current cardioversion and those who had pharmacological cardioversion. Overlap propensity weighting with Cox proportional hazards models was used to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagic stroke or systemic embolism, and major bleeding), adjusting for baseline risk and patient selection. RESULTS 44 201 patients were included in the analysis comparing cardioversion and no cardioversion, and of these, 6595 (14.9%) underwent cardioversion at baseline. The propensity score weighted hazard ratio for all cause mortality in the cardioversion group was 0.74 (95% confidence interval 0.63 to 0.86) from baseline to one year follow-up and 0.77 (0.64 to 0.93) from one year to two year follow-up. Of the 6595 patients who had cardioversion at baseline, 299 had a follow-up cardioversion more than 48 days after enrolment. 7175 patients were assessed in the analysis comparing type of cardioversion: 2427 (33.8%) received pharmacological cardioversion and 4748 (66.2%) had direct current cardioversion. During one year follow-up, event rates (per 100 patient years) for all cause mortality in patients who received direct current and pharmacological cardioversion were 1.36 (1.13 to 1.64) and 1.70 (1.35 to 2.14), respectively. OBJECTIVE To investigate the clinical outcomes of patients who underwent cardioversion compared with those who did not have cardioverson in a large dataset of patients with recent onset non-valvular atrial fibrillation. DESIGN Observational study using prospectively collected registry data (Global Anticoagulant Registry in the FIELD-AF-GARFIELD-AF). SETTING 1317 participating sites in 35 countries. PARTICIPANTS 52 057 patients aged 18 years and older with newly diagnosed atrial fibrillation (up to six weeks' duration) and at least one investigator determined stroke risk factor. MAIN OUTCOME MEASURES Comparisons were made between patients who received cardioversion and those who had no cardioversion at baseline, and between patients who received direct current cardioversion and those who had pharmacological cardioversion. Overlap propensity weighting with Cox proportional hazards models was used to evaluate the effect of cardioversion on clinical endpoints (all cause mortality, non-haemorrhagic stroke or systemic embolism, and major bleeding), adjusting for baseline risk and patient selection. RESULTS 44 201 patients were included in the analysis comparing cardioversion and no cardioversion, and of these, 6595 (14.9%) underwent cardioversion at baseline. The propensity score weighted hazard ratio for all cause mortality in the cardioversion group was 0.74 (95% confidence interval 0.63 to 0.86) from baseline to one year follow-up and 0.77 (0.64 to 0.93) from one year to two year follow-up. Of the 6595 patients who had cardioversion at baseline, 299 had a follow-up cardioversion more than 48 days after enrolment. 7175 patients were assessed in the analysis comparing type of cardioversion: 2427 (33.8%) received pharmacological cardioversion and 4748 (66.2%) had direct current cardioversion. During one year follow-up, event rates (per 100 patient years) for all cause mortality in patients who received direct current and pharmacological cardioversion were 1.36 (1.13 to 1.64) and 1.70 (1.35 to 2.14), respectively. CONCLUSION In this large dataset of patients with recent onset non-valvular atrial fibrillation, a small proportion were treated with cardioversion. Direct current cardioversion was performed twice as often as pharmacological cardioversion, and there appeared to be no major difference in outcome events for these two cardioversion modalities. For the overall cardioversion group, after adjustments for confounders, a significantly lower risk of mortality was found in patients who received early cardioversion compared with those who did not receive early cardioversion. STUDY REGISTRATION ClinicalTrials.gov NCT01090362.
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- 2021
49. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, Sawhney, Jitendra Ps, Kothiwale, Veerappa A, Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, Allu, Jagan, Pieper, Karen S, John Camm, A, Kakkar, Ajay K, GARFIELD-AF Investigators, Xhaet, Olivier, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, Sawhney, Jitendra Ps, Kothiwale, Veerappa A, Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, Allu, Jagan, Pieper, Karen S, John Camm, A, Kakkar, Ajay K, GARFIELD-AF Investigators, and Xhaet, Olivier
- Abstract
The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoag
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- 2021
50. Highlights from the III International Symposium of Thrombosis and Anticoagulation (ISTA), October 14–16, 2010, São Paulo, Brazil
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Lopes, Renato D., Becker, Richard C., Alexander, John H., Armstrong, Paul W., Califf, Robert M., Chan, Mark Y., Crowther, Mark, Granger, Christopher B., Harrington, Robert A., Hylek, Elaine M., James, Stefan K., Jolicoeur, E. Marc, Mahaffey, Kenneth W., Newby, L. Kristin, Peterson, Eric D., Pieper, Karen S., Van de Werf, Frans, Wallentin, Lars, White, Harvey D., Carvalho, Antonio C., Giraldez, Roberto R., Guimaraes, Helio P., Nader, Helena B., Kalil, Renato A. K., Bizzachi, Joyce M. A., Lopes, Antonio C., and Garcia, David A.
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- 2011
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