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352 results on '"Piel, M"'

1. Geometric friction directs cell migration

Author

Berre, M. Le, Liu, Yan-Jun, Hu, J., Maiuri, P., Bénichou, O., Voituriez, R., Chen, Y., and Piel, M.

Subjects
Condensed Matter - Soft Condensed Matter, Quantitative Biology - Cell Behavior
Abstract

In the absence of environmental cues, a migrating cell performs an isotropic random motion. Recently, the breaking of this isotropy has been observed when cells move in the presence of asymmetric adhesive patterns. However, up to now the mechanisms at work to direct cell migration in such environments remain unknown. Here, we show that a non-adhesive surface with asymmetric micro-geometry consisting of dense arrays of tilted micro-pillars can direct cell motion. Our analysis reveals that most features of cell trajectories, including the bias, can be reproduced by a simple model of active Brownian particle in a ratchet potential, which we suggest originates from a generic elastic interaction of the cell body with the environment. The observed guiding effect, independent of adhesion, is therefore robust and could be used to direct cell migration both in vitro and in vivo., Comment: To appear in PRL. Supplementary Information file available on request

Published
2013
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2. Spontaneous contractility--mediated cortical flow generates cell migration in 3-dimensional environments

Author

Hawkins, R. J., Poincloux, R., Bénichou, O., Piel, M., Chavrier, P., and Voituriez, R.

Subjects
Quantitative Biology - Cell Behavior, Condensed Matter - Soft Condensed Matter
Abstract

We present a generic model of cell motility generated by acto-myosin contraction of the cell cortex. We identify analytically dynamical instabilities of the cortex and show that they trigger spontaneous cortical flows which in turn can induce cell migration in 3-dimensional (3D) environments as well as bleb formation. This contractility--based mechanism, widely independent of actin treadmilling, appears as an alternative to the classical picture of lamellipodial motility on flat substrates. Theoretical predictions are compared to experimental data of tumor cells migrating in 3D matrigel and suggest that this mechanism could be a general mode of cell migration in 3D environments., Comment: 4 pages, 4 figures

Published
2010
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3. Pushing off the walls: a mechanism of cell motility in confinement

Author

Hawkins, R. J., Piel, M., Faure-Andre, G., Lennon-Dumenil, A. M., Joanny, J. F., Prost, J., and Voituriez, R.

Subjects
Condensed Matter - Soft Condensed Matter, Quantitative Biology - Cell Behavior
Abstract

We propose a novel mechanism of cell motility, which relies on the coupling of actin polymerization at the cell membrane to geometric confinement. We consider a polymerizing viscoelastic cytoskeletal gel confined in a narrow channel, and show analytically that spontaneous motion occurs. Interestingly, this does not require specific adhesion with the channel walls, and yields velocities potentially larger than the polymerization velocity. The contractile activity of myosin motors is not necessary to trigger motility in this mechanism, but is shown quantitatively to increase the velocity. Our model qualitatively accounts for recent experiments which show that cells without specific adhesion proteins are motile only in confined environments while they are unable to move on a flat surface, and could help in understanding the mechanisms of cell migration in more complex confined geometries such as living tissues., Comment: 4 pages, 3 figures

Published
2009
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5. Author Correction: Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer (Nature Materials, (2022), 10.1038/s41563-022-01431-x)

Author

Frittoli E., Palamidessi A., Iannelli F., Zanardi F., Villa S., Barzaghi L., Abdo H., Cancila V., Beznoussenko G. V., Della Chiara G., Pagani M., Malinverno C., Bhattacharya D., Pisati F., Yu W., Galimberti V., Bonizzi G., Martini E., Mironov A. A., Gioia U., Ascione F., Li Q., Havas K., Magni S., Lavagnino Z., Pennacchio F. A., Maiuri P., Caponi S., Mattarelli M., Martino S., d'Adda di Fagagna F., Rossi C., Lucioni M., Tancredi R., Pedrazzoli P., Vecchione A., Petrini C., Ferrari F., Lanzuolo C., Bertalot G., Nader G., Foiani M., Piel M., Cerbino R., Giavazzi F., Tripodo C., Scita G., Frittoli E., Palamidessi A., Iannelli F., Zanardi F., Villa S., Barzaghi L., Abdo H., Cancila V., Beznoussenko G.V., Della Chiara G., Pagani M., Malinverno C., Bhattacharya D., Pisati F., Yu W., Galimberti V., Bonizzi G., Martini E., Mironov A.A., Gioia U., Ascione F., Li Q., Havas K., Magni S., Lavagnino Z., Pennacchio F.A., Maiuri P., Caponi S., Mattarelli M., Martino S., d'Adda di Fagagna F., Rossi C., Lucioni M., Tancredi R., Pedrazzoli P., Vecchione A., Petrini C., Ferrari F., Lanzuolo C., Bertalot G., Nader G., Foiani M., Piel M., Cerbino R., Giavazzi F., Tripodo C., and Scita G.

Subjects
c-gas, Settore MED/05 - Patologia Clinica, Settore MED/08 - Anatomia Patologica
Abstract

In the version of this article initially published, the first name of Flora Ascione was listed as “Floriana”; the error has been corrected in the HTML and PDF versions of the article.

Published
2023

15. On the consensus nomenclature rules for radiopharmaceutical chemistry – reconsideration of radiochemical conversion

Author

Herth, M., Ametamey, S., Antuganov, D., Bauman, A., Berndt, M., Brooks, A., Bormans, G., Choe, Y., Gillings, N., Häfeli, U., James, M., Kopka, K., Kramer, V., Krasikova, R., Madsen, J., Mu, L., Neumaier, B., Piel, M., Rösch, F., Ross, T., Schibli, R., Scott, P., Shalgunov, V., Vasdev, N., Wadsak, W., Zeglis, B., Herth, M., Ametamey, S., Antuganov, D., Bauman, A., Berndt, M., Brooks, A., Bormans, G., Choe, Y., Gillings, N., Häfeli, U., James, M., Kopka, K., Kramer, V., Krasikova, R., Madsen, J., Mu, L., Neumaier, B., Piel, M., Rösch, F., Ross, T., Schibli, R., Scott, P., Shalgunov, V., Vasdev, N., Wadsak, W., and Zeglis, B.

Abstract

Radiochemical conversion is an important term to be included in the “Consensus nomenclature rules for radiopharmaceutical chemistry”. Radiochemical conversion should be used to define reaction efficiency by measuring the transformation of components in a crude reactionmixture at a given time,whereas radiochemical yield is better suited to define the efficiency of an entire reaction process including, for example, separation, isolation, filtration, and formulation.

Published
2021

17. The nucleus acts as a ruler tailoring cell responses to spatial constraints

Author

Lomakin, A. J., primary, Cattin, C. J., additional, Cuvelier, D., additional, Alraies, Z., additional, Molina, M., additional, Nader, G. P. F., additional, Srivastava, N., additional, Sáez, P. J., additional, Garcia-Arcos, J. M., additional, Zhitnyak, I. Y., additional, Bhargava, A., additional, Driscoll, M. K., additional, Welf, E. S., additional, Fiolka, R., additional, Petrie, R. J., additional, De Silva, N. S., additional, González-Granado, J. M., additional, Manel, N., additional, Lennon-Duménil, A. M., additional, Müller, D. J., additional, and Piel, M., additional

Published
2020
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19. The nucleus acts as a ruler tailoring cell responses to spatial constraints

Author

Lomakin, A.J., primary, Cattin, C.J., additional, Cuvelier, D., additional, Alraies, Z., additional, Molina, M., additional, Nader, G., additional, Srivastava, N., additional, Garcia-Arcos, J.M., additional, Zhitnyak, I.Y., additional, Bhargava, A., additional, Driscoll, M.K., additional, Welf, E.S., additional, Fiolka, R., additional, Petrie, R.J., additional, Manel, N., additional, Lennon-Duménil, A.M., additional, Müller, D.J., additional, and Piel, M., additional

Published
2019
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20. LINC complex-Lisl interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

Author

Infante E, Castagnino A, Ferrari R, Monteiro P, Aguera-Gonzalez S, Paul-Gilloteaux P, Domingues MJ, Maiuri P, Raab M, Shanahan CM, Baffet A, Piel M, Gomes ER, Chavrier P, Infante, E, Castagnino, A, Ferrari, R, Monteiro, P, Aguera-Gonzalez, S, Paul-Gilloteaux, P, Domingues, Mj, Maiuri, P, Raab, M, Shanahan, Cm, Baffet, A, Piel, M, Gomes, Er, and Chavrier, P

Abstract

Cancer cells' ability to migrate through constricting pores in the tissue matrix is limited by nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating confined migration. Here, we show that modulation of matrix pore size or of lamin A expression known to modulate nuclear stiffness directly impinges on levels of MT1-MMP-mediated pericellular collagenolysis by cancer cells. A component of this adaptive response is the centrosome-centered distribution of MT1-MMP intracellular storage compartments ahead of the nucleus. We further show that this response, including invadopodia formation in association with confining matrix fibrils, requires an intact connection between the nucleus and the centrosome via the linker of nucleoskeleton and cytoskeleton (LINC) complex protein nesprin-2 and dynein adaptor Lis1. Our results uncover a digest-on-demand strategy for nuclear translocation through constricted spaces whereby confined migration triggers polarization of MT1-MMP storage compartments and matrix proteolysis in front of the nucleus depending on nucleus-microtubule linkage.

Published
2018

22. Synthesis and evaluation of (S)-2-(2-[ 18F]fluoroethoxy)-4-([3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl-carbamoyl]-methyl)-benzoic acid ([ 18F]repaglinide): a promising radioligand for quantification of pancreatic β-cell mass with positron emission tomography (PET)

Author

Wängler, B, Schneider, S, Thews, O, Schirrmacher, E, Comagic, S, Feilen, P, Schwanstecher, C, Schwanstecher, M, Shiue, C.-Y, Alavi, A, Höhnemann, S, Piel, M, Rösch, F, and Schirrmacher, R

Published
2004
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30. Neurotransmitter receptor density changes in Pitx3AK mice - a model relevant to Parkinson's disease

Author

Cremer, J.N., Amunts, K., Graw, J., Piel, M., Rösch, F., and Zilles, K.

Subjects
Parkinson’s Disease, Pitx3(ak), Mouse Model, Neurotransmitter Receptor
Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by alterations of nigrostriatal dopaminergic neurotransmission. Compared to the wealth of data on the impairment of the dopamine system, relatively limited evidence is available concerning the role of major non-dopaminergic neurotransmitter systems in PD. Therefore, we comprehensively investigated the density and distribution of neurotransmitter receptors for glutamate, GABA, acetylcholine, adrenaline, serotonin, dopamine and adenosine in brains of homozygous aphakia mice being characterized by mutations affecting the Pitx3 gene. This genetic model exhibits crucial hallmarks of PD on the neuropathological, symptomatic and pharmacological level. Quantitative receptor autoradiography was used to characterize 19 different receptor binding sites in eleven brain regions in order to understand receptor changes on a systemic level. We demonstrated striking differential changes of neurotransmitter receptor densities for numerous receptor types and brain regions, respectively. Most prominent, a strong up-regulation of GABA receptors and associated benzodiazepine binding sites in different brain regions and concomitant down-regulations of striatal nicotinic acetylcholine and serotonergic receptor densities were found. Furthermore, the densities of glutamatergic kainate, muscarinic acetylcholine, adrenergic α1 and dopaminergic D2/D3 receptors were differentially altered. These results present novel insights into the expression of neurotransmitter receptors in Pitx3(ak) mice supporting findings on PD pathology in patients and indicating on the possible underlying mechanisms. The data suggest Pitx3(ak) mice as an appropriate new model to investigate the role of neurotransmitter receptors in PD. Our study highlights the relevance of non-dopaminergic systems in PD and for the understanding of its molecular pathology.

Published
2015

31. Mixed Copolymer Adlayers Allowing Reversible Thermal Control of Single Cell Aspect Ratio

Author

Dalier, F., Dubacheva, G. V., Coniel, M., Zanchi, D., Galtayries, A., Piel, M., Marie, E., and Tribet, C.

Abstract

Dynamic guidance of living cells is achieved by fine-tuning and spatiotemporal modulation on artificial polymer layers enabling reversible peptide display. Adjustment of surface composition and interactions is obtained by coadsorption of mixed poly(lysine) derivatives, grafted with either repellent PEG, RGD adhesion peptides, or T-responsive poly(N-isopropylacrylamide) strands. Deposition of mixed adlayers provides a straightforward mean to optimize complex substrates, which is here implemented to achieve (1) thermal control of ligand accessibility and (2) adjustment of relative adhesiveness between adjacent micropatterns, while preserving cell attachment during thermal cycles. The reversible polarization of HeLa cells along orthogonal stripes mimics guidance along natural matrices.

Published
2024
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39. Developers Track of the ESUG International Smalltalk Conference

Author

Bouraqadi, N., Piel, M., Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Lille Douai), Institut Mines-Télécom [Paris] (IMT), Hydrologie hydraulique fluviale et souterraine (UR HHAN), and Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF)

Subjects
[INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; abstract simple

Published
2006

44. Geometric Friction Directs Cell Migration

Author

Le Berre, M., primary, Liu, Yan-Jun, additional, Hu, J., additional, Maiuri, Paolo, additional, Bénichou, O., additional, Voituriez, R., additional, Chen, Y., additional, and Piel, M., additional

Published
2013
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