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216 results on '"Picon, Felipe A."'

1. Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder

Author

Vidor, Marcos Vinícius, Vitola, Eduardo Schneider, Bandeira, Cibele Edom, Martins, Alexandre Ribeiro, de Araujo Tavares, Maria Eduarda, Cupertino, Renata Basso, Panzenhagen, Alana Castro, da Silva, Bruna Santos, Falkenberg, Isabel Ghirardi, Barreto, Pedro Olavo, Teche, Stefania Pigatto, Picon, Felipe Almeida, Rohde, Luis Augusto, Rovaris, Diego L., Bau, Claiton Henrique Dotto, and Grevet, Eugenio Horacio

Published
2024
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2. The course of attention-deficit/hyperactivity disorder through midlife

Author

Grevet, Eugenio Horacio, Bandeira, Cibele Edom, Vitola, Eduardo Schneider, de Araujo Tavares, Maria Eduarda, Breda, Vitor, Zeni, Gregory, Teche, Stefania Pigatto, Picon, Felipe Almeida, Salgado, Carlos Alberto Iglesias, Karam, Rafael Gomes, da Silva, Bruna Santos, Sibley, Margaret H., Rohde, Luis Augusto, Cupertino, Renata Basso, Rovaris, Diego Luiz, and Bau, Claiton Henrique Dotto

Published
2024
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3. Refining patterns of MEF2C effects in white matter microstructure and psychiatric features

Author

de Araujo Tavares, Maria Eduarda, Cupertino, Renata Basso, Bandeira, Cibele Edom, da Silva, Bruna Santos, Vitola, Eduardo Schneider, Salgado, Carlos Alberto Iglesias, dos Santos Soares, Robson, Picon, Felipe Almeida, Rohde, Luis Augusto, Rovaris, Diego Luiz, Grevet, Eugenio Horacio, and Bau, Claiton Henrique Dotto

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Biomedical Imaging, Clinical Research, Genetics, Neurosciences, Mental Health, Human Genome, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Mental health, Humans, White Matter, MEF2 Transcription Factors, Brain, Magnetic Resonance Imaging, Attention Deficit Disorder with Hyperactivity, Anisotropy, MEF2C, Fractional anisotropy, Neuroimaging, MRI, ADHD, Neurology & Neurosurgery, Biological psychology
Abstract

Several GWAS reported Myocyte Enhancer Factor 2 C (MEF2C) gene associations with white matter microstructure and psychiatric disorders, and MEF2C involvement in pathways related to neuronal development suggests a common biological factor underlying these phenotypes. We aim to refine the MEF2C effects in the brain relying on an integrated analysis of white matter and psychiatric phenotypes in an extensively characterized sample. This study included 870 Brazilian adults (47% from an attention-deficit/hyperactivity disorder outpatient clinic) assessed through standardized psychiatric interviews, 139 of which underwent a magnetic resonance imaging scan. We evaluated variants in the MEF2C region using two approaches: 1) a gene-wide analysis, which uses the sum of polymorphism effects, and 2) SNP analyses, restricted to the independent variants within the gene. The outcomes included psychiatric phenotypes and fractional anisotropy for brain images. Results: The gene-wide analyses pointed to a nominal association between MEF2C and the Temporal Portion of the Superior Longitudinal Fasciculus (SLFTEMP). The SNP analysis identified four independent variants significantly associated with SLFTEMP and one (rs4218438) with Substance Use Disorder. Our findings showing specific associations of MEF2C variants with temporal-frontal circuitry components may help to elucidate how the MEF2C gene underlies a broad range of psychiatric phenotypes since these regions are relevant to executive and cognitive functions.

Published
2023

4. A magnetic resonance imaging-based morphometric and structural covariance network study of Brazilian adolescents stratified by depression risk

Author

Rohrsetzer, Fernanda, Balardin, Joana Bisol, Picon, Felipe, Sato, João Ricardo, Battel, Lucas, Viduani, Anna, Manfro, Pedro Henrique, Yoon, Leehyun, Kohrt, Brandon A, Fisher, Helen L, Mondelli, Valeria, Swartz, Johnna R, and Kieling, Christian

Subjects
Paediatrics, Biomedical and Clinical Sciences, Brain Disorders, Clinical Research, Neurosciences, Pediatric, Mental Health, Depression, Mental health, adolescent, depression, risk factors, methods, neuroimaging/structural, Adolescent, Clinical Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

ObjectiveTo explore differences in regional cortical morphometric structure between adolescents at risk for depression or with current depression.MethodsWe analyzed cross-sectional structural neuroimaging data from a sample of 150 Brazilian adolescents classified as low-risk (n=50) or high-risk for depression (n=50) or with current depression (n=50) through a vertex-based approach with measurements of cortical volume, surface area and thickness. Differences between groups in subcortical volumes and in the organization of networks of structural covariance were also explored.ResultsNo significant differences in brain structure between groups were observed in whole-brain vertex-wise cortical volume, surface area or thickness. Also, no significant differences in subcortical volume were observed between risk groups. In relation to the structural covariance network, there was an indication of an increase in the hippocampus betweenness centrality index in the high-risk group network compared to the low-risk and current depression group networks. However, this result was only statistically significant when applying false discovery rate correction for nodes within the affective network.ConclusionIn an adolescent sample recruited using an empirically based composite risk score, no major differences in brain structure were detected according to the risk and presence of depression.

Published
2023

5. Baseline brain volume predicts home-based transcranial direct current stimulation effects on inattention in adults with attention-deficit/hyperactivity disorder

Author

Rodrigues da Silva, Pedro Henrique, Leffa, Douglas T., Luethi, Matthias S., Silva, Roberta F., Ferrazza, Carolina Prietto, Picon, Felipe Almeida, Grevet, Eugenio Horacio, Bau, Claiton Henrique Dotto, Rovaris, Diego Luiz, Razza, Lais B., Caumo, Wolnei, Camprodon, Joan A., Rohde, Luis Augusto Paim, and Brunoni, André R.

Published
2024
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7. Analysis of structural brain asymmetries in attention‐deficit/hyperactivity disorder in 39 datasets

Author

Postema, Merel C, Hoogman, Martine, Ambrosino, Sara, Asherson, Philip, Banaschewski, Tobias, Bandeira, Cibele E, Baranov, Alexandr, Bau, Claiton HD, Baumeister, Sarah, Baur‐Streubel, Ramona, Bellgrove, Mark A, Biederman, Joseph, Bralten, Janita, Brandeis, Daniel, Brem, Silvia, Buitelaar, Jan K, Busatto, Geraldo F, Castellanos, Francisco X, Cercignani, Mara, Chaim‐Avancini, Tiffany M, Chantiluke, Kaylita C, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Cubillo, Ana I, Cupertino, Renata B, de Zeeuw, Patrick, Doyle, Alysa E, Durston, Sarah, Earl, Eric A, Epstein, Jeffery N, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas J, Faraone, Stephen V, Frodl, Thomas, Gabel, Matt C, Gogberashvili, Tinatin, Grevet, Eugenio H, Haavik, Jan, Harrison, Neil A, Hartman, Catharina A, Heslenfeld, Dirk J, Hoekstra, Pieter J, Hohmann, Sarah, Høvik, Marie F, Jernigan, Terry L, Kardatzki, Bernd, Karkashadze, Georgii, Kelly, Clare, Kohls, Gregor, Konrad, Kerstin, Kuntsi, Jonna, Lazaro, Luisa, Lera‐Miguel, Sara, Lesch, Klaus‐Peter, Louza, Mario R, Lundervold, Astri J, Malpas, Charles B, Mattos, Paulo, McCarthy, Hazel, Namazova‐Baranova, Leyla, Nicolau, Rosa, Nigg, Joel T, Novotny, Stephanie E, Weiss, Eileen Oberwelland, Tuura, Ruth L O'Gorman, Oosterlaan, Jaap, Oranje, Bob, Paloyelis, Yannis, Pauli, Paul, Picon, Felipe A, Plessen, Kerstin J, Ramos‐Quiroga, J Antoni, Reif, Andreas, Reneman, Liesbeth, Rosa, Pedro GP, Rubia, Katya, Schrantee, Anouk, Schweren, Lizanne JS, Seitz, Jochen, Shaw, Philip, Silk, Tim J, Skokauskas, Norbert, Vila, Juan C Soliva, Stevens, Michael C, Sudre, Gustavo, Tamm, Leanne, Tovar‐Moll, Fernanda, van Erp, Theo GM, Vance, Alasdair, Vilarroya, Oscar, Vives‐Gilabert, Yolanda, von Polier, Georg G, Walitza, Susanne, Yoncheva, Yuliya N, Zanetti, Marcus V, Ziegler, Georg C, Glahn, David C, and Jahanshad, Neda

Subjects
Biological Psychology, Psychology, Pediatric, Brain Disorders, Mental Health, Neurosciences, Attention Deficit Hyperactivity Disorder (ADHD), Pediatric Research Initiative, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Autism Spectrum Disorder, Brain, Caudate Nucleus, Child, Humans, Magnetic Resonance Imaging, Attention&#8208, deficit, hyperactivity disorder, brain asymmetry, brain laterality, structural MRI, large&#8208, scale data, ENIGMA ADHD Working Group, Attention-deficit, large-scale data, Clinical Sciences, Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Applied and developmental psychology, Clinical and health psychology
Abstract

ObjectiveSome studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.MethodsWe analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.ResultsThere was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward asymmetry of the total hemispheric surface area compared to controls (t = 2.1, p = .04). Lower rightward asymmetry of medial orbitofrontal cortex surface area in ADHD (t = 2.7, p = .01) was similar to a recent finding for autism spectrum disorder. There were also some differences in cortical thickness asymmetry across age groups. In adults with ADHD, globus pallidus asymmetry was altered compared to those without ADHD. However, all effects were small (Cohen's d from -0.18 to 0.18) and would not survive study-wide correction for multiple testing.ConclusionPrior studies of altered structural brain asymmetry in ADHD were likely underpowered to detect the small effects reported here. Altered structural asymmetry is unlikely to provide a useful biomarker for ADHD, but may provide neurobiological insights into the trait.

Published
2021

8. Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

Author

Li, Ting, van Rooij, Daan, Mota, Nina Roth, Buitelaar, Jan K, Ambrosino, Sara, Banaschewski, Tobias, Bandeira, Cibele E, Bau, Claiton HD, Baumeister, Sarah, Baur‐Streubel, Ramona, Bellgrove, Mark A, Biederman, Joseph, Bralten, Janita, Bramati, Ivanei E, Brandeis, Daniel, Berm, Silvia, Busatto, Geraldo F, Calvo, Anna, Castellanos, Francisco X, Cercignani, Mara, Chantiluke, Kaylita C, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Cubillo, Ana I, Cupertino, Renata B, de Zeeuw, Parick, Durston, Sarah, Earl, Eric A, Epstein, Jeffery N, Ethofer, Thomas, Fallgatter, Andreas J, Fair, Damien A, Faraone, Stephen V, Frodl, Thomas, Gabel, Matt C, Gogberashvili, Tinatin, Grevet, Eugenio H, Haavik, Jan, Harrison, Neil A, Hartman, Catharina A, Heslenfeld, Dirk J, Hoekstra, Pieter J, Høvik, Marie F, Jahanshad, Neda, Kardatzki, Bernd, Karkashadze, Georgii, Kelly, Clare, Kohls, Gregor, Konrad, Kerstin, Kuntsi, Jonna, Lazaro, Luisa, Lera‐Miguel, Sara, Lesch, Klaus‐Peter, Louza, Mario R, Lundervold, Astri J, Malpas, Charles B, Mattos, Paulo, McCarthy, Hazel, Nicolau, Rosa, Nigg, Joel T, Tuura, Ruth L O'Gorman, Oosterlaan, Jaap, Oranje, Bob, Paloyelis, Yannis, Pauli, Paul, Picon, Felipe A, Plessen, Kerstin J, Ramos‐Quiroga, J Antoni, Reif, Andreas, Reneman, Liesbeth, Rosa, Pedro GP, Rubia, Katya, Schrantee, Anouk, Schweren, Lizanne JS, Seitz, Jochen, Shaw, Philip, Silk, Tim J, Skokauskas, Norbert, Vila, Juan Carlos Soliva, Soloveva, Anastasiia, Stevens, Michael C, Sudre, Gustavo, Tamm, Leanne, Thompson, Paul M, Tovar‐Moll, Fernanda, van Erp, Theo GM, Vance, Alasdair, Vilarroya, Oscar, Vives‐Gilabert, Yolanda, von Polier, Georg G, Walitza, Susanne, Yoncheva, Yuliya N, Zanetti, Marcus V, Ziegler, Georg C, Anikin, Anatoly, Asherson, Philip, Baranov, Alexandr, Chaim‐Avanicini, Tiffany, and Dale, Anders M

Subjects
Biological Psychology, Psychology, Mental Health, Pediatric, Brain Disorders, Attention Deficit Hyperactivity Disorder (ADHD), Clinical Research, Neurosciences, Adult, Attention Deficit Disorder with Hyperactivity, Brain, Case-Control Studies, Female, Humans, Magnetic Resonance Imaging, Male, Thalamus, ADHD, subcortical volume, neuroanatomic heterogeneity, community detection, effect sizes, ENIGMA ADHD Working Group, Clinical Sciences, Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Applied and developmental psychology, Clinical and health psychology
Abstract

BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes.MethodsUsing the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks.ResultsExploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men.ConclusionsOur results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups.

Published
2021

9. Emerging findings of glutamate–glutamine imbalance in the medial prefrontal cortex in attention deficit/hyperactivity disorder: systematic review and meta-analysis of spectroscopy studies

Author

Vidor, Marcos Vinícius, Panzenhagen, Alana Castro, Martins, Alexandre Ribeiro, Cupertino, Renata Basso, Bandeira, Cibele Edom, Picon, Felipe Almeida, da Silva, Bruna Santos, Vitola, Eduardo Schneider, Rohde, Luis Augusto, Rovaris, Diego Luiz, Bau, Claiton Henrique Dotto, and Grevet, Eugênio Horácio

Published
2022
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12. Association between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence

Author

Rebello, Keila, Moura, Luciana M., Xavier, Gabriela, Spindola, Leticia M., Carvalho, Carolina Muniz, Hoexter, Marcelo Queiroz, Gadelha, Ary, Picon, Felipe, Pan, Pedro Mario, Zugman, André, Grassi-Oliveira, Rodrigo, Brietzke, Elisa, Belangero, Sintia I., Salum, Giovanni Abrahão, Rohde, Luis Augusto, Miguel, Eurípedes Constantino, Bressan, Rodrigo, Jackowski, Andrea, and Sato, João Ricardo

Published
2019
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13. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence

Author

de Araujo, Celia Maria, Zugman, Andre, Swardfager, Walter, Belangero, Sintia Iole Nogueira, Ota, Vanessa Kiyomi, Spindola, Leticia Maria, Hakonarson, Hakon, Pellegrino, Renata, Gadelha, Ary, Salum, Giovanni Abrahão, Pan, Pedro Mario, de Moura, Luciana Monteiro, Del Aquilla, Marco, Picon, Felipe Almeida, Amaro, Edson, Jr., Sato, João Ricardo, Brietzke, Elisa, Grassi-Oliveira, Rodrigo, Rohde, Luis Augusto P., Miguel, Euripedes Constantino, Bressan, Rodrigo A., and Jackowski, Andrea Parolin

Published
2018
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14. Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence

Author

Moura, Luciana Monteiro, Kempton, Matthew, Barker, Gareth, Salum, Giovanni, Gadelha, Ary, Pan, Pedro Mario, Hoexter, Marcelo, Del Aquilla, Marco Antonio Gomes, Picon, Felipe Almeida, Anés, Mauricio, Otaduy, Maria Concepcion Garcia, Amaro, Edson, Jr, Rohde, Luis Augusto, McGuire, Philip, Bressan, Rodrigo Affonseca, Sato, João Ricardo, and Jackowski, Andrea Parolin

Published
2016
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16. An MRI-based morphometric and structural covariance network study of Brazilian adolescents stratified by depression risk

Author

Rohrsetzer, Fernanda, primary, Balardin, Joana Bisol, additional, Picon, Felipe, additional, Sato, João Ricardo, additional, Battel, Lucas, additional, Viduani, Anna, additional, Manfro, Pedro Henrique, additional, Yoon, Leehyun, additional, Kohrt, Brandon A., additional, Fisher, Helen L., additional, Mondelli, Valeria, additional, Swartz, Johnna R., additional, and Kieling, Christian, additional

Published
2023
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17. Primary somatosensory cortex and periaqueductal gray functional connectivity as a marker of the dysfunction of the descending pain modulatory system in fibromyalgia

Author

Soldatelli, Matheus, primary, Franco, Álvaro de Oliveira, additional, Picon, Felipe, additional, Duarte, Juliana Ávila, additional, Scherer, Ricardo, additional, Bandeira, Janete, additional, Zortea, Maxciel, additional, Torres, Iraci Lucena da Silva, additional, Fregni, Felipe, additional, and Caumo, Wolnei, additional

Published
2023
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18. The course of attention-deficit/hyperactivity disorder through midlife

Author

Grevet, Eugenio Horacio, primary, Bandeira, Cibele Edom, additional, Vitola, Eduardo Schneider, additional, de Araujo Tavares, Maria Eduarda, additional, Breda, Vitor, additional, Zeni, Gregory, additional, Teche, Stefania Pigatto, additional, Picon, Felipe Almeida, additional, Salgado, Carlos Alberto Iglesias, additional, Karam, Rafael Gomes, additional, da Silva, Bruna Santos, additional, Sibley, Margaret H., additional, Rohde, Luis Augusto, additional, Cupertino, Renata Basso, additional, Rovaris, Diego Luiz, additional, and Bau, Claiton Henrique Dotto, additional

Published
2022
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19. Age effects on the default mode and control networks in typically developing children

Author

Sato, João Ricardo, Salum, Giovanni Abrahão, Gadelha, Ary, Picon, Felipe Almeida, Pan, Pedro Mario, Vieira, Gilson, Zugman, André, Hoexter, Marcelo Queiroz, Anés, Mauricio, Moura, Luciana Monteiro, Gomes Del'Aquilla, Marco Antonio, Amaro, Edson, Junior, McGuire, Philip, Crossley, Nicolas, Lacerda, Acioly, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Bressan, Rodrigo Affonseca, and Jackowski, Andrea Parolin

Published
2014
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20. Transcranial Direct Current Stimulation vs Sham for the Treatment of Inattention in Adults With Attention-Deficit/Hyperactivity Disorder

Author

Leffa, Douglas Teixeira, primary, Grevet, Eugenio Horacio, additional, Bau, Claiton Henrique Dotto, additional, Schneider, Maitê, additional, Ferrazza, Carolina Prietto, additional, da Silva, Roberta Francieli, additional, Miranda, Marina Silva, additional, Picon, Felipe, additional, Teche, Stefania Pigatto, additional, Sanches, Paulo, additional, Pereira, Danton, additional, Rubia, Katya, additional, Brunoni, André Russowsky, additional, Camprodon, Joan A., additional, Caumo, Wolnei, additional, and Rohde, Luis Augusto, additional

Published
2022
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21. Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Author

Patel, Yash, primary, Shin, Jean, additional, Abé, Christoph, additional, Agartz, Ingrid, additional, Alloza, Clara, additional, Alnæs, Dag, additional, Ambrogi, Sonia, additional, Antonucci, Linda A., additional, Arango, Celso, additional, Arolt, Volker, additional, Auzias, Guillaume, additional, Ayesa-Arriola, Rosa, additional, Banaj, Nerisa, additional, Banaschewski, Tobias, additional, Bandeira, Cibele, additional, Başgöze, Zeynep, additional, Cupertino, Renata Basso, additional, Bau, Claiton H.D., additional, Bauer, Jochen, additional, Baumeister, Sarah, additional, Bernardoni, Fabio, additional, Bertolino, Alessandro, additional, Bonnin, Caterina del Mar, additional, Brandeis, Daniel, additional, Brem, Silvia, additional, Bruggemann, Jason, additional, Bülow, Robin, additional, Bustillo, Juan R., additional, Calderoni, Sara, additional, Calvo, Rosa, additional, Canales-Rodríguez, Erick J., additional, Cannon, Dara M., additional, Carmona, Susanna, additional, Carr, Vaughan J., additional, Catts, Stanley V., additional, Chenji, Sneha, additional, Chew, Qian Hui, additional, Coghill, David, additional, Connolly, Colm G., additional, Conzelmann, Annette, additional, Craven, Alexander R., additional, Crespo-Facorro, Benedicto, additional, Cullen, Kathryn, additional, Dahl, Andreas, additional, Dannlowski, Udo, additional, Davey, Christopher G., additional, Deruelle, Christine, additional, Díaz-Caneja, Covadonga M., additional, Dohm, Katharina, additional, Ehrlich, Stefan, additional, Epstein, Jeffery, additional, Erwin-Grabner, Tracy, additional, Eyler, Lisa T., additional, Fedor, Jennifer, additional, Fitzgerald, Jacqueline, additional, Foran, William, additional, Ford, Judith M., additional, Fortea, Lydia, additional, Fuentes-Claramonte, Paola, additional, Fullerton, Janice, additional, Furlong, Lisa, additional, Gallagher, Louise, additional, Gao, Bingchen, additional, Gao, Si, additional, Goikolea, Jose M., additional, Gotlib, Ian, additional, Goya-Maldonado, Roberto, additional, Grabe, Hans J., additional, Green, Melissa, additional, Grevet, Eugenio H., additional, Groenewold, Nynke A., additional, Grotegerd, Dominik, additional, Gruber, Oliver, additional, Haavik, Jan, additional, Hahn, Tim, additional, Harrison, Ben J., additional, Heindel, Walter, additional, Henskens, Frans, additional, Heslenfeld, Dirk J., additional, Hilland, Eva, additional, Hoekstra, Pieter J., additional, Hohmann, Sarah, additional, Holz, Nathalie, additional, Howells, Fleur M., additional, Ipser, Jonathan C., additional, Jahanshad, Neda, additional, Jakobi, Babette, additional, Jansen, Andreas, additional, Janssen, Joost, additional, Jonassen, Rune, additional, Kaiser, Anna, additional, Kaleda, Vasiliy, additional, Karantonis, James, additional, King, Joseph A., additional, Kircher, Tilo, additional, Kochunov, Peter, additional, Koopowitz, Sheri-Michelle, additional, Landén, Mikael, additional, Landrø, Nils Inge, additional, Lawrie, Stephen, additional, Lebedeva, Irina, additional, Luna, Beatriz, additional, Lundervold, Astri J., additional, MacMaster, Frank P., additional, Maglanoc, Luigi A., additional, Mathalon, Daniel H., additional, McDonald, Colm, additional, McIntosh, Andrew, additional, Meinert, Susanne, additional, Michie, Patricia T., additional, Mitchell, Philip, additional, Moreno-Alcázar, Ana, additional, Mowry, Bryan, additional, Muratori, Filippo, additional, Nabulsi, Leila, additional, Nenadić, Igor, additional, O'Gorman Tuura, Ruth, additional, Oosterlaan, Jaap, additional, Overs, Bronwyn, additional, Pantelis, Christos, additional, Parellada, Mara, additional, Pariente, Jose C., additional, Pauli, Paul, additional, Pergola, Giulio, additional, Piarulli, Francesco Maria, additional, Picon, Felipe, additional, Piras, Fabrizio, additional, Pomarol-Clotet, Edith, additional, Pretus, Clara, additional, Quidé, Yann, additional, Radua, Joaquim, additional, Ramos-Quiroga, J. Antoni, additional, Rasser, Paul E., additional, Reif, Andreas, additional, Retico, Alessandra, additional, Roberts, Gloria, additional, Rossell, Susan, additional, Rovaris, Diego Luiz, additional, Rubia, Katya, additional, Sacchet, Matthew D., additional, Salavert, Josep, additional, Salvador, Raymond, additional, Sarró, Salvador, additional, Sawa, Akira, additional, Schall, Ulrich, additional, Scott, Rodney, additional, Selvaggi, Pierluigi, additional, Silk, Tim, additional, Sim, Kang, additional, Skoch, Antonin, additional, Spalletta, Gianfranco, additional, Spaniel, Filip, additional, Stein, Dan J., additional, Steinsträter, Olaf, additional, Stolicyn, Aleks, additional, Takayanagi, Yoichiro, additional, Tamm, Leanne, additional, Tavares, Maria, additional, Teumer, Alexander, additional, Thiel, Katharina, additional, Thomopoulos, Sophia I., additional, Tomecek, David, additional, Tomyshev, Alexander S., additional, Tordesillas-Gutiérrez, Diana, additional, Tosetti, Michela, additional, Uhlmann, Anne, additional, Van Rheenen, Tamsyn, additional, Vazquez-Bourgón, Javier, additional, Vernooij, Meike W., additional, Vieta, Eduard, additional, Vilarroya, Oscar, additional, Weickert, Cynthia, additional, Weickert, Thomas, additional, Westlye, Lars T., additional, Whalley, Heather, additional, Willinger, David, additional, Winter, Alexandra, additional, Wittfeld, Katharina, additional, Yang, Tony T., additional, Yoncheva, Yuliya, additional, Zijlmans, Jendé L., additional, Hoogman, Martine, additional, Franke, Barbara, additional, van Rooij, Daan, additional, Buitelaar, Jan, additional, Ching, Christopher R.K., additional, Andreassen, Ole A., additional, Pozzi, Elena, additional, Veltman, Dick, additional, Schmaal, Lianne, additional, van Erp, Theo G.M., additional, Turner, Jessica, additional, Castellanos, F. Xavier, additional, Pausova, Zdenka, additional, Thompson, Paul, additional, and Paus, Tomas, additional

Published
2022
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22. Cognitive Deficits in Adults with ADHD Go beyond Comorbidity Effects

Author

Silva, Katiane L., Guimaraes-da-Silva, Paula O., Grevet, Eugenio H., Victor, Marcelo M., Salgado, Carlos A. I., Vitola, Eduardo S., Mota, Nina R., Fischer, Aline G., Contini, Veronica, Picon, Felipe A., Karam, Rafael G., Belmonte-de-Abreu, Paulo, Rohde, Luis A., and Bau, Claiton H. D.

Abstract

Objective: This study addresses if deficits in cognitive, attention, and inhibitory control performance in adults with ADHD are better explained by the disorder itself or by comorbid conditions. Method Adult patients with ADHD ("n" = 352) and controls ("n" = 94) were evaluated in the ADHD program of a tertiary hospital. The diagnostic process for ADHD and comorbidities was based on "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.; "DSM-IV") criteria. Stepwise regression analyses evaluated the effect of ADHD, demographics, and comorbidities on the scores from Wechsler Adult Intelligence Scale-Revised, Continuous Performance Test, and Stroop Color and Word Test. Results: Patients with ADHD of both genders had worse performance on neuropsychological domains, even after adjustment for comorbidities. The presence of comorbid bipolar disorder and specific phobia are associated with more Stroop errors, whereas patients with generalized anxiety disorder present a longer execution time in Stroop. Conclusion: Neuropsychological deficits in adults with ADHD go beyond comorbidity. Specific comorbid disorders may influence the neuropsychological functioning in adults with ADHD. (Contains 2 tables.)

Published
2013
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23. Associations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children

Author

Rebello, Keila, primary, Moura, Luciana Monteiro, additional, Bueno, Ana Paula Arantes, additional, Picon, Felipe Almeida, additional, Pan, Pedro Mario, additional, Gadelha, Ary, additional, Miguel, Euripedes Constatino, additional, Bressan, Rodrigo Affonseca, additional, Rohde, Luis Augusto, additional, and Sato, João Ricardo, additional

Published
2022
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24. P73. Transcranial Direct Current Stimulation for the Treatment of Inattention in Adult Patients With ADHD: Results From the TUNED Trial

Author

Leffa, Douglas, primary, Schneider, Maitê, additional, Ferraza, Carolina, additional, Francieli, Roberta, additional, Miranda, Marina, additional, Bau, Claiton, additional, Grevet, Eugenio, additional, Picon, Felipe, additional, Caumo, Wolnei, additional, Júnior, Danton Pereira, additional, Sanches, Paulo, additional, Rubia, Katya, additional, Brunoni, André, additional, Camprodon-Gimenez, Joan, additional, and Rohde, Luis, additional

Published
2022
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25. Virtual ontogeny of cortical growth preceding mental illness

Author

German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne University of Technology, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Medical Research Foundation, Society for Mental Health Research (Australia), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute (Australia), European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia [0000-0002-2897-358X], Banaschewski, Tobias [0000-0003-4595-1144], Bandeira, Cibele Edom [0000-0003-0681-1309], Cupertino, Renata [0000-0002-3452-0632], Calderoni, Sara [0000-0002-6250-5739], Cannon, Dara [0000-0001-7378-3411], Carr, Vaughan [0000-0002-8907-5804], Chew, Qian Hui [0000-0003-0969-7994], Coghill, David [0000-0003-3017-9737], Cullen, Kathryn [0000-0001-9631-3770], Dahl, Andreas [0000-0002-8097-2082], Epstein, Jeffery [0000-0003-3464-5256], Foran, William [0000-0001-7491-9798], Fortea, Lydia [0000-0001-6778-2316], Fuentes-Claramonte, Paola [0000-0002-1428-7976], Fullerton, Janice M. [0000-0003-4014-4490], Furlong, Lisa [0000-0001-6196-4565], Gallagher, Louise [0000-0001-9462-2836], Gao, Si [0000-0002-4473-1142], Gotlib, Ian [0000-0002-3622-3199], Haavik, Jan [0000-0001-7865-2808], Henskens, Frans [0000-0003-2358-5630], Hilland, Eva [0000-0002-7102-8372], Hoekstra, Pieter J [0000-0001-7260-4119], Howells, Fleur M [0000-0001-9759-2556], Ipser, Jonathan [0000-0003-1272-0032], Jørgensen, Jes Kristian [0000-0001-9133-1670], Karantonis, James A. [0000-0003-2281-0912], Lawrie, Stephen [0000-0002-2444-5675], Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Gruber, Oliver, Haavik, Jan, McDonald, Colm, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, King, Joseph A., Vernooij, Meike W., Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., McIntosh, Andrew, Ipser, Jonathan C., Meinert, Susanne, Hoogman, Martine, Kircher, Tilo, Kochunov, Peter, Vieta, Eduard, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Michie, Patricia T., Ayesa Arriola, Rosa, Mitchell, Philip, Moreno-Alcázar, Ana, Franke, Barbara, Mowry, Bryan, Bau, Claiton H. D., Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Banaj, Nerisa, Parellada, Mara, van Rooij, Daan, Vilarroya, Oscar, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Banaschewski, Tobias, Weickert, Cynthia, Buitelaar, Jan, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Weickert, Thomas, Sacchet, Matthew, Ching, Christopher R. K., Bandeira, Cibele, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Westlye, Lars T., Silk, Tim, Sim, Kang, Andreassen, Ole A., Skoch, Antonin, Başgöze, Zeynep, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Whalley, Heather, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Pozzi, Elena, Teumer, Alexander, Thiel, Katharina, Cupertino, Renata Basso, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Willinger, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Veltman, Dick, Vázquez-Bourgon, Javier, Schmaal, Lianne, Jahanshad, Neda, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Bauer, Jochen, Zijlmans, Jendé L., Baumeister, Sarah, Lebedeva, Irina, van Erp, Theo G. M., Turner, Jessica, Jakobi, Babette, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Luna, Beatriz, Brem, Silvia, Jansen, Andreas, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Lundervold, Astri J., Janssen, Joost, Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Jonassen, Rune, MacMaster, Frank P., Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Kaiser, Anna, Fedor, Jennifer, Maglanoc, Luigi A., Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Kaleda, Vasiliy, Gao, Bingchen, Gao, Si, Mathalon, Daniel H., Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Karantonis, James, Grotegerd, Dominik., German Research Foundation, University of Münster, National Health and Medical Research Council (Australia), University of Cape Town, National Research Foundation (South Africa), Swinburne University of Technology, Jack Brockhoff Foundation, University of Melbourne, Barbara Dicker Brain Sciences Foundation, Rebecca L. Cooper Medical Research Foundation, Society for Mental Health Research (Australia), Swedish Research Council, Swedish Foundation for Strategic Research, Swedish Brain Foundation, Health Research Board (Ireland), Russian Foundation for Basic Research, University of Zurich, Pratt Foundation, Ramsay Health Care, Viertel Charitable Foundation, Schizophrenia Research Institute (Australia), European Commission, Australian Research Council, Instituto de Salud Carlos III, National Institute for Health and Care Research (US), National Institute for Health Research (UK), Ministry of Health of the Czech Republic, Bill & Melinda Gates Foundation, South African Medical Research Council, Carnegie Corporation of New York, Wellcome Trust, Medical Research Council (UK), Medical Research Scotland, Netherlands Organization for Scientific Research, Ambrogi, Sonia [0000-0002-2897-358X], Banaschewski, Tobias [0000-0003-4595-1144], Bandeira, Cibele Edom [0000-0003-0681-1309], Cupertino, Renata [0000-0002-3452-0632], Calderoni, Sara [0000-0002-6250-5739], Cannon, Dara [0000-0001-7378-3411], Carr, Vaughan [0000-0002-8907-5804], Chew, Qian Hui [0000-0003-0969-7994], Coghill, David [0000-0003-3017-9737], Cullen, Kathryn [0000-0001-9631-3770], Dahl, Andreas [0000-0002-8097-2082], Epstein, Jeffery [0000-0003-3464-5256], Foran, William [0000-0001-7491-9798], Fortea, Lydia [0000-0001-6778-2316], Fuentes-Claramonte, Paola [0000-0002-1428-7976], Fullerton, Janice M. [0000-0003-4014-4490], Furlong, Lisa [0000-0001-6196-4565], Gallagher, Louise [0000-0001-9462-2836], Gao, Si [0000-0002-4473-1142], Gotlib, Ian [0000-0002-3622-3199], Haavik, Jan [0000-0001-7865-2808], Henskens, Frans [0000-0003-2358-5630], Hilland, Eva [0000-0002-7102-8372], Hoekstra, Pieter J [0000-0001-7260-4119], Howells, Fleur M [0000-0001-9759-2556], Ipser, Jonathan [0000-0003-1272-0032], Jørgensen, Jes Kristian [0000-0001-9133-1670], Karantonis, James A. [0000-0003-2281-0912], Lawrie, Stephen [0000-0002-2444-5675], Patel, Yash, Shin, Jean, Abé, Christoph, Agartz, Ingrid, Alloza, Clara, Alnæs, Dag, Ambrogi, Sonia, Antonucci, Linda A., Arango, Celso, Arolt, Volker, Auzias, Guillaume, Gruber, Oliver, Haavik, Jan, McDonald, Colm, Hahn, Tim, Harrison, Ben J., Heindel, Walter, Henskens, Frans, Heslenfeld, Dirk J., Hilland, Eva, King, Joseph A., Vernooij, Meike W., Hoekstra, Pieter J., Hohmann, Sarah, Holz, Nathalie, Howells, Fleur M., McIntosh, Andrew, Ipser, Jonathan C., Meinert, Susanne, Hoogman, Martine, Kircher, Tilo, Kochunov, Peter, Vieta, Eduard, Koopowitz, Sheri-Michelle, Landén, Mikael, Landrø, Nils Inge, Lawrie, Stephen, Michie, Patricia T., Ayesa Arriola, Rosa, Mitchell, Philip, Moreno-Alcázar, Ana, Franke, Barbara, Mowry, Bryan, Bau, Claiton H. D., Muratori, Filippo, Nabulsi, Leila, Nenadić, Igor, O'Gorman Tuura, Ruth, Oosterlaan, Jaap, Overs, Bronwyn, Pantelis, Christos, Banaj, Nerisa, Parellada, Mara, van Rooij, Daan, Vilarroya, Oscar, Pariente, Jose C., Pauli, Paul, Pergola, Giulio, Piarulli, Francesco Maria, Picon, Felipe, Piras, Fabrizio, Pomarol-Clotet, Edith, Pretus, Clara, Quidé, Yann, Banaschewski, Tobias, Weickert, Cynthia, Buitelaar, Jan, Radua, Joaquim, Ramos-Quiroga, J. Antoni, Rasser, Paul E., Reif, Andreas, Retico, Alessandra, Roberts, Gloria, Rossell, Susan, Rovaris, Diego Luiz, Rubia, Katya, Weickert, Thomas, Sacchet, Matthew, Ching, Christopher R. K., Bandeira, Cibele, Salavert, Josep, Salvador, Raymond, Sarró, Salvador, Sawa, Akira, Schall, Ulrich, Scott, Rodney, Selvaggi, Pierluigi, Westlye, Lars T., Silk, Tim, Sim, Kang, Andreassen, Ole A., Skoch, Antonin, Başgöze, Zeynep, Spalletta, Gianfranco, Spaniel, Filip, Stein, Dan J., Steinsträter, Olaf, Stolicyn, Aleks, Whalley, Heather, Takayanagi, Yoichiro, Tamm, Leanne, Tavares, Maria, Pozzi, Elena, Teumer, Alexander, Thiel, Katharina, Cupertino, Renata Basso, Thomopoulos, Sophia I., Tomecek, David, Tomyshev, Alexander S., Willinger, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Uhlmann, Anne, Van Rheenen, Tamsyn, Veltman, Dick, Vázquez-Bourgon, Javier, Schmaal, Lianne, Jahanshad, Neda, Winter, Alexandra, Wittfeld, Katharina, Yang, Tony T., Yoncheva, Yuliya, Bauer, Jochen, Zijlmans, Jendé L., Baumeister, Sarah, Lebedeva, Irina, van Erp, Theo G. M., Turner, Jessica, Jakobi, Babette, Castellanos, F. Xavier, Pausova, Zdenka, Thompson, Paul, Paus, Tomas, Bernardoni, Fabio, Bertolino, Alessandro, Bonnin, Caterina Del Mar, Brandeis, Daniel, Luna, Beatriz, Brem, Silvia, Jansen, Andreas, Bruggemann, Jason, Bülow, Robin, Bustillo, Juan R., Calderoni, Sara, Calvo, Rosa, Canales-Rodríguez, Erick J., Cannon, Dara M., Carmona, Susanna, Carr, Vaughan J., Lundervold, Astri J., Janssen, Joost, Catts, Stanley V., Chenji, Sneha, Chew, Qian Hui, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Craven, Alexander R., Crespo-Facorro, Benedicto, Cullen, Kathryn, Dahl, Andreas, Jonassen, Rune, MacMaster, Frank P., Dannlowski, Udo, Davey, Christopher G., Deruelle, Christine, Díaz-Caneja, Covadonga M., Dohm, Katharina, Ehrlich, Stefan, Epstein, Jeffery, Erwin-Grabner, Tracy, Eyler, Lisa T., Kaiser, Anna, Fedor, Jennifer, Maglanoc, Luigi A., Fitzgerald, Jacqueline, Foran, William, Ford, Judith M., Fortea, Lydia, Fuentes-Claramonte, Paola, Fullerton, Janice, Furlong, Lisa, Gallagher, Louise, Kaleda, Vasiliy, Gao, Bingchen, Gao, Si, Mathalon, Daniel H., Goikolea, Jose M., Gotlib, Ian, Goya-Maldonado, Roberto, Grabe, Hans J., Green, Melissa, Grevet, Eugenio H., Groenewold, Nynke A., Karantonis, James, and Grotegerd, Dominik.

Abstract

[Background]: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life., [Methods]: Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed., [Results]: Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth., [Conclusions]: Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.

Published
2022

29. Predictors of gaming disorder in Brazilian children and adolescents: a school-based study

Author

Ferreira, Felipe de M., Bambini, Beatriz B., Tonsig, Gabriela K., Fonseca, Lais, Picon, Felipe A., Pan, Pedro M., Salum, Giovanni A., Jackowski, Andrea, Miguel, Eurípedes C., Rohde, Luis A., Bressan, Rodrigo A., and Gadelha, Ary

Subjects
game genres, Internet, Schools, Adolescent, Gaming disorder, online games, Brief Communication, mental disorders, Behavior, Addictive, Disruptive, Impulse Control, and Conduct Disorders, predictors, Video Games, Humans, Child, human activities, Brazil, gaming session
Abstract

Objective: To determine whether psychiatric and gaming pattern variables are associated with gaming disorder in a school-based sample. Methods: We analyzed data from the Brazilian High-Risk Cohort for Psychiatric Disorders, a community sample aged 10 to 18, using questionnaires on gaming use patterns. We applied the Gaming Addiction Scale to diagnose gaming disorder and the Development and Well-Being Behavior Assessment for other diagnoses. Results: Out of 407 subjects, 83 (20.4%) fulfilled the criteria for gaming disorder. More role-playing game players were diagnosed with gaming disorder that any other genre. Gaming disorder rates increased proportionally to the number of genres played. Playing online, being diagnosed with a mental disorder, and more hours of non-stop gaming were associated with higher rates of gaming disorder. When all variables (including age and gender) were considered in a logistic regression model, the number of genres played, the number of non-stop hours, the proportion of online games, and having a diagnosed mental disorder emerged as significant predictors of gaming disorder. Conclusion: Each variable seems to add further risk of gaming disorder among children and adolescents. Monitoring the length of gaming sessions, the number and type of genres played, time spent gaming online, and behavior changes may help parents or guardians identify unhealthy patterns of gaming behavior.

Published
2020

32. SYT1 Gene-Wide Analysis on White Matter Microstructure in Adulthood ADHD

Author

Cupertino, Renata Basso, primary, Silva, Bruna Santos da, additional, Schuch, Jaqueline Bohrer, additional, Bandeira, Cibele Edom, additional, Tavares, Maria Eduarda, additional, Cunha, Pamela Ferreira da, additional, Picon, Felipe Almeida, additional, Vitola, Eduardo Schneider, additional, Rovaris, Diego Luiz, additional, Grevet, Eugenio Horacio, additional, and Bau, Claiton Henrique Dotto, additional

Published
2021
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35. Default mode network maturation and psychopathology in children and adolescents

Author

Sato, João Ricardo, Salum, Giovanni Abrahão, Gadelha, Ary, Crossley, Nicolas, Vieira, Gilson, Manfro, Gisele Gus, Zugman, André, Picon, Felipe Almeida, Pan, Pedro Mario, Hoexter, Marcelo Queiroz, Anés, Mauricio, Moura, Luciana Monteiro, DelʼAquilla, Marco Antonio Gomes, Jr, Edson Amaro, McGuire, Philip, Lacerda, Acioly Luiz Tavares, Rohde, Luis Augusto, Miguel, Euripedes Constantino, Jackowski, Andrea Parolin, and Bressan, Rodrigo Affonseca

Published
2016
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36. TU1. POLYGENIC RISK SCORE ANALYSES FOR ATTENTION-DEFICIT/HYPERACTIVITY DISORDER TRAJECTORIES IN ADULTS

Author

Bandeira, Cibele Edom, primary, Grevet, Eugenio Horacio, additional, Vitola, Eduardo S., additional, Tavares, Maria Eduarda, additional, Breda, Vitor, additional, Zeni, Gregory, additional, Teche, Stefania Pigatto, additional, Picon, Felipe Almeida, additional, da Silva, Bruna Santos, additional, Rohde, Luis Augusto, additional, Cupertino, Renata Basso, additional, Rovaris, Diego Luiz, additional, and Bau, Claiton H.D., additional

Published
2021
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37. TH52. REFINING PATTERNS OF MEF2C ASSOCIATIONS WITH WHITE MATTER MICROSTRUCTURE AND PSYCHIATRIC FEATURES

Author

Tavares, Maria de Araujo, primary, Cupertino, Renata Basso, additional, Bandeira, Cibele Edom, additional, da Silva, Bruna Santos, additional, Vitola, Eduardo S., additional, Salgado, Carlos A.I., additional, Soares, Robson dos Santos, additional, Picon, Felipe Almeida, additional, Rovaris, Diego Luiz, additional, Grevet, Eugênio H., additional, and Bau, Claiton H.D., additional

Published
2021
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38. Long‐term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence

Author

Sato, João Ricardo, primary, Biazoli, Claudinei Eduardo, additional, Zugman, André, additional, Pan, Pedro Mario, additional, Bueno, Ana Paula Arantes, additional, Moura, Luciana Monteiro, additional, Gadelha, Ary, additional, Picon, Felipe Almeida, additional, Amaro, Edson, additional, Salum, Giovanni Abrahão, additional, Miguel, Euripedes Constantino, additional, Rohde, Luis Augusto, additional, Bressan, Rodrigo Affonseca, additional, and Jackowski, Andrea Parolin, additional

Published
2021
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41. Predictors of gaming disorder in children and adolescents: a school-based study

Author

Ferreira, Felipe de M., primary, Bambini, Beatriz B., additional, Tonsig, Gabriela K., additional, Fonseca, Lais, additional, Picon, Felipe A., additional, Pan, Pedro M., additional, Salum, Giovanni A., additional, Jackowski, Andrea, additional, Miguel, Eurípedes C., additional, Rohde, Luis A., additional, Bressan, Rodrigo A., additional, and Gadelha, Ary, additional

Published
2021
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42. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders

Author

Committee, Writing, Disorder, Autism Spectrum, French, Leon, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Guerrero-Pedraza, Amalia, Gur, Raquel E, Gur, Ruben C, Haar, Shlomi, Haarman, Bartholomeus C M, Thomopoulos, Sophia I, Haavik, Jan, Hahn, Tim, Hajek, Tomas, Harrison, Benjamin J, Harrison, Neil A, Hartman, Catharina A, Whalley, Heather C, Heslenfeld, Dirk J, Hibar, Derrek P, Hilland, Eva, Pozzi, Elena, Hirano, Yoshiyuki, Ho, Tiffany C, Hoekstra, Pieter J, Hoekstra, Liesbeth, Hohmann, Sarah, Hong, L. E., Höschl, Cyril, Høvik, Marie F, Howells, Fleur M, Nenadic, Igor, Abe, Yoshinari, Jalbrzikowski, Maria, James, Anthony C, Janssen, Joost, Jaspers-Fayer, Fern, Xu, Jian, Jonassen, Rune, Karkashadze, Georgii, King, Joseph A, Kircher, Tilo, Kirschner, Matthias, Abé, Christoph, Koch, Kathrin, Kochunov, Peter, Kohls, Gregor, Konrad, Kerstin, Krämer, Bernd, Krug, Axel, Kuntsi, Jonna, Kwon, Jun Soo, Landén, Mikael, Landrø, Nils I, Anticevic, Alan, Lazaro, Luisa, Lebedeva, Irina S, Leehr, Elisabeth J, Lera-Miguel, Sara, Lesch, Klaus-Peter, Lochner, Christine, Louza, Mario R, Luna, Beatriz, Lundervold, Astri J, MacMaster, Frank P, Alda, Martin, Maglanoc, Luigi A, Malpas, Charles B, Portella, Maria J, Marsh, Rachel, Martyn, Fiona M, Mataix-Cols, David, Mathalon, Daniel H, McCarthy, Hazel, McDonald, Colm, McPhilemy, Genevieve, Aleman, Andre, Meinert, Susanne, Menchón, José M, Minuzzi, Luciano, Mitchell, Philip B, Moreno, Carmen, Morgado, Pedro, Muratori, Filippo, Murphy, Clodagh M, Murphy, Declan, Mwangi, Benson, Alloza, Clara, Nabulsi, Leila, Nakagawa, Akiko, Nakamae, Takashi, Namazova, Leyla, Narayanaswamy, Janardhanan, Jahanshad, Neda, Nguyen, Danai D, Nicolau, Rosa, O'Gorman Tuura, Ruth L, O'Hearn, Kirsten, Alonso-Lana, Silvia, Oosterlaan, Jaap, Opel, Nils, Ophoff, Roel A, Oranje, Bob, García de la Foz, Victor Ortiz, Overs, Bronwyn J, Paloyelis, Yannis, Pantelis, Christos, Parellada, Mara, Pauli, Paul, Disorder, Bipolar, Ameis, Stephanie H, Picó-Pérez, Maria, Picon, Felipe A, Piras, Fabrizio, Piras, Federica, Plessen, Kerstin J, Pomarol-Clotet, Edith, Preda, Adrian, Puig, Olga, Quidé, Yann, Radua, Joaquim, Anagnostou, Evdokia, Ramos-Quiroga, J Antoni, Rasser, Paul E, Rauer, Lisa, Reddy, Janardhan, Redlich, Ronny, Reif, Andreas, Reneman, Liesbeth, Repple, Jonathan, Retico, Alessandra, Richarte, Vanesa, McIntosh, Andrew A, Richter, Anja, Rosa, Pedro G P, Rubia, Katya K, Hashimoto, Ryota, Sacchet, Matthew D, Salvador, Raymond, Santonja, Javier, Sarink, Kelvin, Sarró, Salvador, Satterthwaite, Theodore D, Arango, Celso, Sawa, Akira, Schall, Ulrich, Schofield, Peter R, Schrantee, Anouk, Seitz, Jochen, Serpa, Mauricio H, Setién-Suero, Esther, Shaw, Philip, Shook, Devon, Silk, Tim J, Arnold, Paul D, Sim, Kang, Simon, Schmitt, Simpson, Helen Blair, Singh, Aditya, Skoch, Antonin, Skokauskas, Norbert, Soares, Jair C, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Asherson, Philip, Spaniel, Filip, Lawrie, Stephen M, Stern, Emily R, Stewart, S Evelyn, Takayanagi, Yoichiro, Temmingh, Henk S, Tolin, David F, Tomecek, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Assogna, Francesca, Uhlmann, Anne, van Amelsvoort, Therese, van der Wee, Nic J A, van der Werff, Steven J A, van Haren, Neeltje E M, van Wingen, Guido A, Vance, Alasdair, Vázquez-Bourgon, Javier, Vecchio, Daniela, Venkatasubramanian, Ganesan, Auzias, Guillaume, Vieta, Eduard, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle N, Völzke, Henry, von Polier, Georg G, Walton, Esther, Weickert, Thomas W, Weickert, Cynthia Shannon, Weideman, Andrea S, Ayesa-Arriola, Rosa, Wittfeld, Katharina, Wolf, Daniel H, Wu, Mon-Ju, Yang, T. T., Yang, Sikun, Yoncheva, Yuliya, Yun, Je-Yeon, Cheng, Yuqi, Zanetti, Marcus V, Ziegler, Georg C, Bakker, Geor, Franke, Barbara, Hoogman, Martine, Buitelaar, Jan K, van Rooij, Daan, Andreassen, Ole A, Ching, Christopher R K, Veltman, Dick J, Schmaal, Lianne, Stein, Dan J, van den Heuvel, Odile A, Disorder, Major Depressive, Banaj, Nerisa, Turner, Jessica A, van Erp, Theo G M, Pausova, Zdenka, Thompson, Paul M, Paus, Tomáš, Attention-Deficit/Hyperactivity Disorder, Banaschewski, Tobias, Bandeira, Cibele E, Baranov, Alexandr, Bargalló, Núria, Bau, Claiton H D, Baumeister, Sarah, Baune, Bernhard T, Bellgrove, Mark A, Benedetti, Francesco, Disorder, Obsessive-Compulsive, Bertolino, Alessandro, Boedhoe, Premika S W, Boks, Marco, Bollettini, Irene, Del Mar Bonnin, Caterina, Borgers, Tiana, Borgwardt, Stefan, Brandeis, Daniel, Brennan, Brian P, Bruggemann, Jason M, Groups, Schizophrenia ENIGMA Working, Bülow, Robin, Busatto, Geraldo F, Calderoni, Sara, Calhoun, Vince D, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carr, Vaughan J, Cascella, Nicola, Cercignani, Mara, Patel, Yash, Chaim-Avancini, Tiffany M, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Crespo-Facorro, Benedicto, Cubillo, Ana I, Cullen, Kathryn R, Cupertino, Renata B, Daly, Eileen, Dannlowski, Udo, Parker, Nadine, Davey, Christopher G, Denys, Damiaan, Deruelle, Christine, Di Giorgio, Annabella, Dickie, Erin W, Dima, Danai, Dohm, Katharina, Ehrlich, Stefan, Ely, Benjamin A, Erwin-Grabner, Tracy, Shin, Jean, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas, Faraone, Stephen V, Fatjó-Vilas, Mar, Fedor, Jennifer M, Fitzgerald, Kate D, Ford, Judith M, Frodl, Thomas, Fu, Cynthia H Y, Howard, Derek, Fullerton, Janice M, Gabel, Matt C, Glahn, David C, Roberts, Gloria, Gogberashvili, Tinatin, Goikolea, Jose M, Gotlib, Ian H, Goya-Maldonado, Roberto, Grabe, Hans, Green, Melissa J, Patel, Y., Parker, N., Shin, J., Howard, D., French, L., Thomopoulos, S. I., Pozzi, E., Abe, Y., Abe, C., Anticevic, A., Alda, M., Aleman, A., Alloza, C., Alonso-Lana, S., Ameis, S. H., Anagnostou, E., Mcintosh, A. A., Arango, C., Arnold, P. D., Asherson, P., Assogna, F., Auzias, G., Ayesa-Arriola, R., Bakker, G., Banaj, N., Banaschewski, T., Bandeira, C. E., Baranov, A., Bargallo, N., Bau, C. H. D., Baumeister, S., Baune, B. T., Bellgrove, M. A., Benedetti, F., Bertolino, A., Boedhoe, P. S. W., Boks, M., Bollettini, I., Del Mar Bonnin, C., Borgers, T., Borgwardt, S., Brandeis, D., Brennan, B. P., Bruggemann, J. M., Bulow, R., Busatto, G. F., Calderoni, S., Calhoun, V. D., Calvo, R., Canales-Rodriguez, E. J., Cannon, D. M., Carr, V. J., Cascella, N., Cercignani, M., Chaim-Avancini, T. M., Christakou, A., Coghill, D., Conzelmann, A., Crespo-Facorro, B., Cubillo, A. I., Cullen, K. R., Cupertino, R. B., Daly, E., Dannlowski, U., Davey, C. G., Denys, D., Deruelle, C., Di Giorgio, A., Dickie, E. W., Dima, D., Dohm, K., Ehrlich, S., Ely, B. A., Erwin-Grabner, T., Ethofer, T., Fair, D. A., Fallgatter, A. J., Faraone, S. V., Fatjo-Vilas, M., Fedor, J. M., Fitzgerald, K. D., Ford, J. M., Frodl, T., Fu, C. H. Y., Fullerton, J. M., Gabel, M. C., Glahn, D. C., Roberts, G., Gogberashvili, T., Goikolea, J. M., Gotlib, I. H., Goya-Maldonado, R., Grabe, H. J., Green, M. J., Grevet, E. H., Groenewold, N. A., Grotegerd, D., Gruber, O., Gruner, P., Guerrero-Pedraza, A., Gur, R. E., Gur, R. C., Haar, S., Haarman, B. C. M., Haavik, J., Hahn, T., Hajek, T., Harrison, B. J., Harrison, N. A., Hartman, C. A., Whalley, H. C., Heslenfeld, D. J., Hibar, D. P., Hilland, E., Hirano, Y., Ho, T. C., Hoekstra, P. J., Hoekstra, L., Hohmann, S., Hong, L. E., Hoschl, C., Hovik, M. F., Howells, F. M., Nenadic, I., Jalbrzikowski, M., James, A. C., Janssen, J., Jaspers-Fayer, F., Xu, J., Jonassen, R., Karkashadze, G., King, J. A., Kircher, T., Kirschner, M., Koch, K., Kochunov, P., Kohls, G., Konrad, K., Kramer, B., Krug, A., Kuntsi, J., Kwon, J. S., Landen, M., Landro, N. I., Lazaro, L., Lebedeva, I. S., Leehr, E. J., Lera-Miguel, S., Lesch, K. -P., Lochner, C., Louza, M. R., Luna, B., Lundervold, A. J., Macmaster, F. P., Maglanoc, L. A., Malpas, C. B., Portella, M. J., Marsh, R., Martyn, F. M., Mataix-Cols, D., Mathalon, D. H., Mccarthy, H., Mcdonald, C., Mcphilemy, G., Meinert, S., Menchon, J. M., Minuzzi, L., Mitchell, P. B., Moreno, C., Morgado, P., Muratori, F., Murphy, C. M., Murphy, D., Mwangi, B., Nabulsi, L., Nakagawa, A., Nakamae, T., Namazova, L., Narayanaswamy, J., Jahanshad, N., Nguyen, D. D., Nicolau, R., O'Gorman Tuura, R. L., O'Hearn, K., Oosterlaan, J., Opel, N., Ophoff, R. A., Oranje, B., Garcia De La Foz, V. O., Overs, B. J., Paloyelis, Y., Pantelis, C., Parellada, M., Pauli, P., Pico-Perez, M., Picon, F. A., Piras, F., Plessen, K. J., Pomarol-Clotet, E., Preda, A., Puig, O., Quide, Y., Radua, J., Ramos-Quiroga, J. A., Rasser, P. E., Rauer, L., Reddy, J., Redlich, R., Reif, A., Reneman, L., Repple, J., Retico, A., Richarte, V., Richter, A., Rosa, P. G. P., Rubia, K. K., Hashimoto, R., Sacchet, M. D., Salvador, R., Santonja, J., Sarink, K., Sarro, S., Satterthwaite, T. D., Sawa, A., Schall, U., Schofield, P. R., Schrantee, A., Seitz, J., Serpa, M. H., Setien-Suero, E., Shaw, P., Shook, D., Silk, T. J., Sim, K., Simon, S., Simpson, H. B., Singh, A., Skoch, A., Skokauskas, N., Soares, J. C., Soreni, N., Soriano-Mas, C., Spalletta, G., Spaniel, F., Lawrie, S. M., Stern, E. R., Stewart, S. E., Takayanagi, Y., Temmingh, H. S., Tolin, D. F., Tomecek, D., Tordesillas-Gutierrez, D., Tosetti, M., Uhlmann, A., Van Amelsvoort, T., Van Der Wee, N. J. A., Van Der Werff, S. J. A., Van Haren, N. E. M., Van Wingen, G. A., Vance, A., Vazquez-Bourgon, J., Vecchio, D., Venkatasubramanian, G., Vieta, E., Vilarroya, O., Vives-Gilabert, Y., Voineskos, A. N., Volzke, H., Von Polier, G. G., Walton, E., Weickert, T. W., Weickert, C. S., Weideman, A. S., Wittfeld, K., Wolf, D. H., Wu, M. -J., Yang, T. T., Yang, K., Yoncheva, Y., Yun, J. -Y., Cheng, Y., Zanetti, M. V., Ziegler, G. C., Franke, B., Hoogman, M., Buitelaar, J. K., Van Rooij, D., Andreassen, O. A., Ching, C. R. K., Veltman, D. J., Schmaal, L., Stein, D. J., Van Den Heuvel, O. A., Turner, J. A., Van Erp, T. G. M., Pausova, Z., Thompson, P. M., Paus, T., Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Pediatric surgery, Radiology and nuclear medicine, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Neurodegeneration, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Med Staf Spec Psychiatrie (9), Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, General Paediatrics, ARD - Amsterdam Reproduction and Development, Radiology and Nuclear Medicine, APH - Personalized Medicine, ANS - Brain Imaging, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, University of Zurich, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Clinical Neuropsychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Child and Adolescent Psychiatry / Psychology, IBBA, and Cognitive Psychology

Subjects
Male, Obsessive-Compulsive Disorder, Bipolar Disorder, Autism Spectrum Disorder, Autism, [SDV]Life Sciences [q-bio], Gene Expression, cytology [Cerebral Cortex], Cohort Studies, Fetal Development, physiology [Gene Expression], 2738 Psychiatry and Mental Health, 0302 clinical medicine, diagnostic imaging [Cerebral Cortex], SCHIZOPHRENIA, BRAIN, Child, Obsessive-compulsive disorder (OCD), Original Investigation, Aged, 80 and over, Cerebral Cortex, 0303 health sciences, pathology [Depressive Disorder, Major], Principal Component Analysis, Adolescent psychiatry, 10058 Department of Child and Adolescent Psychiatry, Middle Aged, diagnostic imaging [Obsessive-Compulsive Disorder], REGIONS, Magnetic Resonance Imaging, 3. Good health, FALSE DISCOVERY RATE, Psychiatry and Mental health, Autism spectrum disorder, Schizophrenia, growth & development [Cerebral Cortex], Child, Preschool, Major depressive disorder, diagnostic imaging [Schizophrenia], Esquizofrènia, Female, Psiquiatria infantil, Psiquiatria de l'adolescència, diagnostic imaging [Autism Spectrum Disorder], Adult, medicine.medical_specialty, Adolescent, Human Development, 610 Medicine & health, diagnostic imaging [Bipolar Disorder], pathology [Autism Spectrum Disorder], diagnostic imaging [Depressive Disorder, Major], 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Neuroimaging, SDG 3 - Good Health and Well-being, CEREBRAL-CORTEX, Child psychiatry, medicine, Attention deficit hyperactivity disorder, Humans, Bipolar disorder, ddc:610, Psychiatry, pathology [Schizophrenia], 030304 developmental biology, Aged, Depressive Disorder, Major, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, DENDRITE, Computational Biology, Correction, pathology [Attention Deficit Disorder with Hyperactivity], physiology [Fetal Development], medicine.disease, PATHOLOGY, pathology [Bipolar Disorder], pathology [Obsessive-Compulsive Disorder], 10036 Medical Clinic, Attention Deficit Disorder with Hyperactivity, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Case-Control Studies, DENSITY, ORIGINS, HIPPOCAMPUS, diagnostic imaging [Attention Deficit Disorder with Hyperactivity], pathology [Cerebral Cortex], Autisme, business, Neuroscience, 030217 neurology & neurosurgery, physiology [Human Development]
Abstract

[Importance] Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood., [Objective] To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia., [Design, Setting, and Participants] Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244., [Main Outcomes and Measures] Interregional profiles of group difference in cortical thickness between cases and controls., [Results] A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders., [Conclusions and Relevance] In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.

Published
2021

43. Predictors of gaming disorder in children and adolescents : a school-based study

Author

Ferreira, Felipe de M., Bambini, Beatriz B., Tonsig, Gabriela K., Fonseca, Laís, Picon, Felipe Almeida, Salum Junior, Giovanni Abrahão, Jackowski, Andrea Parolin, Miguel, Eurípedes Constantino, Rohde, Luis Augusto Paim, Bressan, Rodrigo Affonseca, and Gadelha, Ary

Subjects
Gaming disorder, Predictors, Prognóstico, Jogos de vídeo, Gaming session, Criança, Game genres, Mental disorders, Online games, Transtornos mentais, Adolescente
Abstract

Objective: To determine whether psychiatric and gaming pattern variables are associated with gaming disorder in a school-based sample. Methods: We analyzed data from the Brazilian High-Risk Cohort for Psychiatric Disorders, a community sample aged 10 to 18, using questionnaires on gaming use patterns. We applied the Gaming Addiction Scale to diagnose gaming disorder and the Development and Well-Being Behavior Assessment for other diagnoses. Results: Out of 407 subjects, 83 (20.4%) fulfilled the criteria for gaming disorder. More role-playing game players were diagnosed with gaming disorder that any other genre. Gaming disorder rates increased proportionally to the number of genres played. Playing online, being diagnosed with a mental disorder, and more hours of non-stop gaming were associated with higher rates of gaming disorder. When all variables (including age and gender) were considered in a logistic regression model, the number of genres played, the number of non-stop hours, the proportion of online games, and having a diagnosed mental disorder emerged as significant predictors of gaming disorder. Conclusion: Each variable seems to add further risk of gaming disorder among children and adolescents. Monitoring the length of gaming sessions, the number and type of genres played, time spent gaming online, and behavior changes may help parents or guardians identify unhealthy patterns of gaming behavior.

Published
2021

45. Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan

Author

Cupertino, Renata Basso, Grevet, Eugenio Horácio, Bandeira, Cibele Edom, Picon, Felipe Almeida, Tavares, Maria Eduarda de Araujo, Vitola, Eduardo Schneider, Breda, Vitor Carlos Thumé, Bau, Claiton Henrique Dotto, and Sprooten, Emma

Subjects
Substância branca, Lobo frontal, Fronto-striatal, White matter, Estudos de coortes, ADHD, Tensor-based morphometry, Anatomia humana, Independent component analysis, Transtorno do déficit de atenção com hiperatividade, Neuroimagem
Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) has been associated with altered brain anatomy in neuroimaging studies. However, small and heterogeneous study samples, and the use of region-of-interest and tissuespecific analyses have limited the consistency and replicability of these effects. We used a data-driven multivariate approach to investigate neuroanatomical features associated with ADHD in two independent cohorts: the Dutch NeuroIMAGE cohort (n = 890, 17.2 years) and the Brazilian IMpACT cohort (n = 180, 44.2 years). Using independent component analysis of whole-brain morphometry images, 375 neuroanatomical components were assessed for association with ADHD. In both discovery (corrected-p = 0.0085) and replication (p = 0.032) cohorts, ADHD was associated with reduced volume in frontal lobes, striatum, and their interconnecting whitematter. Current results provide further evidence for the role of the fronto-striatal circuit in ADHD in children, and for the first time show its relevance to ADHD in adults. The fact that the cohorts are from different continents and comprise different age ranges highlights the robustness of the findings.

Published
2020

47. Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan

Author

Cupertino, Renata Basso, primary, Soheili-Nezhad, Sourena, additional, Grevet, Eugenio Horacio, additional, Bandeira, Cibele Edom, additional, Picon, Felipe Almeida, additional, Tavares, Maria Eduarda de Araujo, additional, Naaijen, Jilly, additional, van Rooij, Daan, additional, Akkermans, Sophie, additional, Vitola, Eduardo Schneider, additional, Zwiers, Marcel P, additional, Rovaris, Diego Luiz, additional, Hoekstra, Pieter J., additional, Breda, Vitor, additional, Oosterlaan, Jaap, additional, Hartman, Catharina A, additional, Beckmann, Christian F, additional, Buitelaar, Jan K, additional, Franke, Barbara, additional, Bau, Claiton Henrique Dotto, additional, and Sprooten, Emma, additional

Published
2020
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48. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?

Author

de Araujo, Celia Maria, primary, Swardfager, Walter, additional, Zugman, Andre, additional, Cogo-Moreira, Hugo, additional, Belangero, Sintia I., additional, Ota, Vanessa K., additional, Spindola, Leticia M., additional, Hakonarson, Hakon, additional, Pellegrino, Renata, additional, Gadelha, Ary, additional, Salum, Giovanni A., additional, Pan, Pedro M., additional, Mansur, Rodrigo B., additional, Hoexter, Marcelo, additional, Picon, Felipe, additional, Sato, João R., additional, Brietzke, Elisa, additional, Grassi-Oliveira, Rodrigo, additional, Rohde, Luis A. P., additional, Miguel, Euripedes C., additional, Bressan, Rodrigo A., additional, and Jackowski, Andrea P., additional

Published
2019
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49. Neuroimaging Association Scores: reliability and validity of aggregate measures of brain structural features linked to mental disorders in youth.

Author

Axelrud, Luiza Kvitko, Simioni, André Rafael, Pine, Daniel Samuel, Winkler, Anderson Marcelo, Pan, Pedro Mario, Sato, João Ricardo, Zugman, André, Parker, Nadine, Picon, Felipe, Jackowski, Andrea, Hoexter, Marcelo Queiroz, IMAGEN Consortium, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Quinlan, Erin Burke, Desrivières, Sylvane, Flor, Herta, Grigis, Antoine, and Garavan, Hugh

Subjects
BRAIN anatomy, RESEARCH evaluation, COGNITION, MAGNETIC resonance imaging, CEREBRAL cortex anatomy, PATHOLOGICAL psychology, NEURORADIOLOGY, MENTAL illness
Abstract

In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6–14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS were derived by summing the product of each standardized brain feature by the effect size of the association of that brain feature with seven psychiatric disorders documented by previous meta-analyses. NAS were calculated for surface area, cortical thickness and subcortical volumes using T1-weighted scans. NAS reliability, temporal stability and psychopathology and cognition prediction were analyzed. NAS for surface area showed high internal consistency and 3-year stability and predicted general psychopathology and cognition with higher replicability than specific symptomatic domains for all samples. They also predicted general psychopathology with higher replicability than single structures alone, accounting for 1–3% of the variance, but without directionality. The NAS for cortical thickness and subcortical volumes showed lower internal consistency and less replicable associations with behavioural phenotypes. These findings indicate the NAS based on surface area might be replicable markers of general psychopathology, but these links are unlikely to be causal or clinically useful yet. [ABSTRACT FROM AUTHOR]

Published
2021
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