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1. A National Comparative Investigation of Twins With Congenital Heart Defects for Neurodevelopmental Outcomes and Quality of Life (Same Same, but Different?): Protocol for a Prospective Observational Study

Author

Remmele, Julia, Helm, Paul Christian, Oberhoffer-Fritz, Renate, Bauer, Ulrike MM, Pickardt, Thomas, Ewert, Peter, and Tutarel, Oktay

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundDue to the increased survival rates of patients with congenital heart defects (CHD), associated disorders are an increasing focus of research. Existing studies figured out an association between CHD and its treatment, and neurodevelopmental outcomes including motor competence impairments. All these studies, however, compared their test results with reference values or results of healthy control groups. This comparison is influenced by socioeconomic and genetic aspects, which do have a known impact on neurodevelopmental outcomes. ObjectiveThis study protocol describes a setting that aims to find out the role of CHD and its treatments on neurodevelopmental outcomes, excluding socioeconomic and genetic aspects. Only a twin comparison provides the possibility to exclude these confounding factors. MethodsIn a German-wide prospective cohort study, 129 twin siblings registered in the National Register for Congenital Heart Defects will undergo testing on cognitive function (Wechsler Intelligence Tests age-dependent: Wechsler Adult Intelligence Scale, fourth edition; Wechsler Intelligence Scale for Children, fifth edition; and Wechsler Preschool and Primary Scale of Intelligence, fourth edition) and motor competence (Movement Assessment Battery for Children, second edition). Additionally, the self-reported health-related quality of life (KINDL-R for children, Short Form 36 for adults) and the parent-reported strength and difficulties of the children (Strength and Difficulties Questionnaire, German version) will be assessed by standardized questionnaires. CHD data on the specific diagnosis, surgeries, transcatheter procedures, and additional medical information will be received from patient records. ResultsThe approval of the Medical Ethics Committee Charité Mitte was obtained in June 2018. After getting funded in April 2019, the first enrollment was in August 2019. The study is still ongoing until June 2022. Final results are expected in 2022. ConclusionsThis study protocol provides an overview of the study design’s technical details, offering an option to exclude confounding factors on neurodevelopmental outcomes in patients with CHD. This will enable a specific analysis focusing on CHD and clinical treatments to differentiate in terms of neurodevelopmental outcomes of patients with CHD compared to twin siblings with healthy hearts. Finally, we aim to clearly define what is important to prevent patients with CHD in terms of neurodevelopmental impairments to be able to develop targeted prevention strategies for patients with CHD. Trial RegistrationGerman Clinical Trials Register DRKS00021087; https://tinyurl.com/2rdw8w67 International Registered Report Identifier (IRRID)DERR1-10.2196/26404

Published
2021
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2. Le Cœur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot.

Author

Mîra, Anna, Lamata, Pablo, Pushparajah, Kuberan, Abraham, Georgina, Mauger, Charlène, McCulloch, Andrew, Omens, Jeffrey, Bissell, Malenka, Blair, Zach, Huffaker, Tyler, Tandon, Animesh, Engelhardt, Sandy, Koehler, Sven, Pickardt, Thomas, Beerbaum, Philipp, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Young, Alistair, and Hussain, Tarique

Subjects
Biomarker, Biventricular shape, Magnetic resonance imaging, Tetralogy of Fallot, Cardiac Surgical Procedures, Humans, Predictive Value of Tests, Pulmonary Valve Insufficiency, Tetralogy of Fallot, Ventricular Function, Right
Abstract

BACKGROUND: Maladaptive remodelling mechanisms occur in patients with repaired tetralogy of Fallot (rToF) resulting in a cycle of metabolic and structural changes. Biventricular shape analysis may indicate mechanisms associated with adverse events independent of pulmonary regurgitant volume index (PRVI). We aimed to determine novel remodelling patterns associated with adverse events in patients with rToF using shape and function analysis. METHODS: Biventricular shape and function were studied in 192 patients with rToF (median time from TOF repair to baseline evaluation 13.5 years). Linear discriminant analysis (LDA) and principal component analysis (PCA) were used to identify shape differences between patients with and without adverse events. Adverse events included death, arrhythmias, and cardiac arrest with median follow-up of 10 years. RESULTS: LDA and PCA showed that shape characteristics pertaining to adverse events included a more circular left ventricle (LV) (decreased eccentricity), dilated (increased sphericity) LV base, increased right ventricular (RV) apical sphericity, and decreased RV basal sphericity. Multivariate LDA showed that the optimal discriminative model included only RV apical ejection fraction and one PCA mode associated with a more circular and dilated LV base (AUC = 0.77). PRVI did not add value, and shape changes associated with increased PRVI were not predictive of adverse outcomes. CONCLUSION: Pathological remodelling patterns in patients with rToF are significantly associated with adverse events, independent of PRVI. Mechanisms related to incident events include LV basal dilation with a reduced RV apical ejection fraction.

Published
2022

3. Unsupervised Domain Adaptation from Axial to Short-Axis Multi-Slice Cardiac MR Images by Incorporating Pretrained Task Networks

Author

Koehler, Sven, Hussain, Tarique, Blair, Zach, Huffaker, Tyler, Ritzmann, Florian, Tandon, Animesh, Pickardt, Thomas, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Wolf, Ivo, and Engelhardt, Sandy

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Anisotropic multi-slice Cardiac Magnetic Resonance (CMR) Images are conventionally acquired in patient-specific short-axis (SAX) orientation. In specific cardiovascular diseases that affect right ventricular (RV) morphology, acquisitions in standard axial (AX) orientation are preferred by some investigators, due to potential superiority in RV volume measurement for treatment planning. Unfortunately, due to the rare occurrence of these diseases, data in this domain is scarce. Recent research in deep learning-based methods mainly focused on SAX CMR images and they had proven to be very successful. In this work, we show that there is a considerable domain shift between AX and SAX images, and therefore, direct application of existing models yield sub-optimal results on AX samples. We propose a novel unsupervised domain adaptation approach, which uses task-related probabilities in an attention mechanism. Beyond that, cycle consistency is imposed on the learned patient-individual 3D rigid transformation to improve stability when automatically re-sampling the AX images to SAX orientations. The network was trained on 122 registered 3D AX-SAX CMR volume pairs from a multi-centric patient cohort. A mean 3D Dice of $0.86\pm{0.06}$ for the left ventricle, $0.65\pm{0.08}$ for the myocardium, and $0.77\pm{0.10}$ for the right ventricle could be achieved. This is an improvement of $25\%$ in Dice for RV in comparison to direct application on axial slices. To conclude, our pre-trained task module has neither seen CMR images nor labels from the target domain, but is able to segment them after the domain gap is reduced. Code: https://github.com/Cardio-AI/3d-mri-domain-adaptation, Comment: Accepted for IEEE Transaction on Medical Imaging (TMI) 2021 on 13.01.2021

Published
2021
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4. Clinical course and follow-up of pediatric patients with COVID-19 vaccine-associated myocarditis compared to non–vaccine-associated myocarditis within the prospective multicenter registry—“MYKKE”

Author

Rolfs, Nele, Huber, Cynthia, Schwarzkopf, Eicke, Mentzer, Dirk, Keller-Stanislawski, Brigitte, Opgen-Rhein, Bernd, Frede, Wiebke, Rentzsch, Axel, Hecht, Tobias, Boehne, Martin, Grafmann, Maria, Kiski, Daniela, Graumann, Iva, Foth, Rudi, Voges, Inga, Schweigmann, Ulrich, Ruf, Bettina, Fischer, Marcus, Wiegand, Gesa, Klingel, Karin, Pickardt, Thomas, Friede, Tim, Messroghli, Daniel, Schubert, Stephan, and Seidel, Franziska

Published
2024
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5. How well do U-Net-based segmentation trained on adult cardiac magnetic resonance imaging data generalise to rare congenital heart diseases for surgical planning?

Author

Koehler, Sven, Tandon, Animesh, Hussain, Tarique, Latus, Heiner, Pickardt, Thomas, Sarikouch, Samir, Beerbaum, Philipp, Greil, Gerald, Engelhardt, Sandy, and Wolf, Ivo

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Planning the optimal time of intervention for pulmonary valve replacement surgery in patients with the congenital heart disease Tetralogy of Fallot (TOF) is mainly based on ventricular volume and function according to current guidelines. Both of these two biomarkers are most reliably assessed by segmentation of 3D cardiac magnetic resonance (CMR) images. In several grand challenges in the last years, U-Net architectures have shown impressive results on the provided data. However, in clinical practice, data sets are more diverse considering individual pathologies and image properties derived from different scanner properties. Additionally, specific training data for complex rare diseases like TOF is scarce. For this work, 1) we assessed the accuracy gap when using a publicly available labelled data set (the Automatic Cardiac Diagnosis Challenge (ACDC) data set) for training and subsequent applying it to CMR data of TOF patients and vice versa and 2) whether we can achieve similar results when applying the model to a more heterogeneous data base. Multiple deep learning models were trained with four-fold cross validation. Afterwards they were evaluated on the respective unseen CMR images from the other collection. Our results confirm that current deep learning models can achieve excellent results (left ventricle dice of $0.951\pm{0.003}$/$0.941\pm{0.007}$ train/validation) within a single data collection. But once they are applied to other pathologies, it becomes apparent how much they overfit to the training pathologies (dice score drops between $0.072\pm{0.001}$ for the left and $0.165\pm{0.001}$ for the right ventricle)., Comment: Accepted for SPIE Medical Imaging 2020

Published
2020

6. Self-supervised Motion Descriptor for Cardiac Phase Detection in 4D CMR Based on Discrete Vector Field Estimations

Author

Koehler, Sven, Hussain, Tarique, Hussain, Hamza, Young, Daniel, Sarikouch, Samir, Pickardt, Thomas, Greil, Gerald, Engelhardt, Sandy, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Camara, Oscar, editor, Puyol-Antón, Esther, editor, Qin, Chen, editor, Sermesant, Maxime, editor, Suinesiaputra, Avan, editor, Wang, Shuo, editor, and Young, Alistair, editor

Published
2022
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7. Clinical characteristics and outcome of biopsy-proven myocarditis in children – Results of the German prospective multicentre registry “MYKKE”

Author

Seidel, Franziska, Opgen-Rhein, Bernd, Rentzsch, Axel, Boehne, Martin, Wannenmacher, Bardo, Boecker, Dorotheé, Reineker, Katja, Grafmann, Maria, Wiegand, Gesa, Hecht, Tobias, Kiski, Daniela, Fischer, Marcus, Papakostas, Konstantin, Ruf, Bettina, Kramp, Jennifer, Khalil, Marcus, Kaestner, Michael, Steinmetz, Michael, Fischer, Gunther, Özcan, Sevinc, Freudenthal, Noa, Schweigmann, Ulrich, Hellwig, Regina, Pickardt, Thomas, Klingel, Karin, Messroghli, Daniel, and Schubert, Stephan

Published
2022
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8. Prognostic Value of Speckle Tracking Echocardiography-Derived Strain in Unmasking Risk for Arrhythmias in Children with Myocarditis.

Author

Rolfs, Nele, Huber, Cynthia, Opgen-Rhein, Bernd, Altmann, Isabell, Anderheiden, Felix, Hecht, Tobias, Fischer, Marcus, Wiegand, Gesa, Reineker, Katja, Voges, Inga, Kiski, Daniela, Frede, Wiebke, Boehne, Martin, Khedim, Malika, Messroghli, Daniel, Klingel, Karin, Schwarzkopf, Eicke, Pickardt, Thomas, Schubert, Stephan, and Lunze, Fatima I.

Subjects
SPECKLE tracking echocardiography, ARRHYTHMIA, ECHOCARDIOGRAPHY, MAJOR adverse cardiovascular events, ARTIFICIAL blood circulation
Abstract

Background/Objectives: Risk assessment in pediatric myocarditis is challenging, particularly when left ventricular ejection fraction (LVEF) is preserved. This study aimed to evaluate LV myocardial deformation using speckle-tracking echocardiography (STE)-derived longitudinal +strain (LS) and assessed its diagnostic and prognostic value in children with myocarditis. Methods: Retrospective STE-derived layer-specific LV LS analysis was performed on echocardiograms from patients within the multicenter, prospective registry for pediatric myocarditis "MYKKE". Age- and sex-adjusted logistic regression and ROC analysis identified predictors of cardiac arrhythmias (ventricular tachycardia, ventricular fibrillation, atrioventricular blockage III°) and major adverse cardiac events (MACE: need for mechanical circulatory support (MCS), cardiac transplantation, and/or cardiac death). Results: Echocardiograms from 175 patients (median age 15 years, IQR 7.9–16.5 years; 70% male) across 13 centers were included. Cardiac arrhythmias occurred in 36 patients (21%), and MACE in 28 patients (16%). Impaired LV LS strongly correlated with reduced LVEF (r > 0.8). Impaired layer-specific LV LS, reduced LVEF, LV dilatation, and increased BSA-indexed LV mass, were associated with the occurrence of MACE and cardiac arrhythmias. In patients with preserved LVEF, LV LS alone predicted cardiac arrhythmias (p < 0.001), with optimal cutoff values of −18.0% for endocardial LV LS (sensitivity 0.69, specificity 0.94) and –17.0% for midmyocardial LV LS (sensitivity 0.81, specificity 0.75). Conclusions: In pediatric myocarditis, STE-derived LV LS is not only a valuable tool for assessing systolic myocardial dysfunction and predicting MACE but also identifies patients at risk for cardiac arrhythmias, even in the context of preserved LVEF. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Relationship Between Shape and Contractile Function in Left Ventricles of Patients with Repaired Tetralogy of Fallot: Cardiac Mri-derived Computational Study

Author

Gusseva, Maria, primary, Hussain, Tarique, additional, Pickardt, Thomas, additional, Beerbaum, Philipp, additional, Sarikouch, Samir, additional, Latus, Heiner, additional, Greil, Gerald, additional, Chabiniok, Radomir, additional, Chapelle, Dominque, additional, Lamata, Pablo, additional, and Tandon, Animesh, additional

Published
2024
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12. Spatially Resolved Radiomics Feature Signatures in LGE MRI in Children and Adolescents with Myocarditis – Observations From the Multicenter Registry MYKKE

Author

Laube, Ann, primary, Huellebrand, Markus, additional, Ter-Minassian, Léa, additional, Schwarzkopf, Eicke, additional, Opgen-Rhein, Bernd, additional, Rolfs, Nele, additional, Anderheiden, Felix, additional, Wannenmacher, Bardo, additional, Wiegand, Gesa, additional, Boehne, Martin, additional, Uden, Theodor, additional, Reineker, Katja, additional, Rentzsch, Axel, additional, Fischer, Marcus, additional, Kaestner, Michael, additional, Hecht, Tobias, additional, Foth, Rudi, additional, Ruf, Bettina, additional, Pickardt, Thomas, additional, Schubert, Stephan, additional, Messroghli, Daniel, additional, Seidel, Franziska, additional, and Hennemuth, Anja, additional

Published
2024
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13. Clinical course and follow-up of pediatric patients with COVID-19 vaccine-associated myocarditis compared to non-vaccine-associated myocarditis within the prospective multi-center registry - “MYKKE”

Author

Rolfs, Nele, primary, Huber, Cynthia, additional, Schwarzkopf, Eicke, additional, Mentzer, Dirk, additional, Keller-Stanislawski, B, additional, Opgen-Rhein, Bernd, additional, Frede, Wiebke, additional, Rentzsch, Axel, additional, Hecht, Tobias, additional, Boehne, Martin, additional, Grafmann, Maria, additional, Kiski, Daniela, additional, Graumann, Iva, additional, Foth, Rudi, additional, Voges, Inga, additional, Schweigmann, Ulrich, additional, Ruf, Bettina, additional, Fischer, Marcus, additional, Wiegand, Gesa, additional, Klingel, Karin, additional, Pickardt, Thomas, additional, Friede, Tim, additional, Messroghli, Daniel, additional, Schubert, Stephan, additional, and Seidel, Franziska, additional

Published
2023
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14. Somatic Development in Children with Congenital Heart Defects

Author

Kerst, Gunter, Vazquez-Jimenez, Jaime F., Gkalpakiotis, Dimitrios, Schedifka, Andrea, Buheitel, Gernot, Streble, Joachim, II, Kececioglu, Deniz, Sandica, Eugen, Trusen, Burkhard, Berger, Felix, Miera, Oliver, Ovroutski, Stanislav, Peters, Björn, Schmitt, Katharina, Schubert, Stephan, Photiadis, Joachim, Opgen-Rhein, Bernd, Weiss, Katja, Berns, Christoph, Blumenthal-Barby, Carl-Christian, Boeckel, Thomas, Krusche, Susanne, Busse, Jürgen, Kästner, Andreas, Koch, Heike, Köpcke, Christian, Streichan, Frank, Timme, Jens, Franzbach, Birgit, Senft, Gabriela, Beyer, Frank, Winter, Klaus, Breuer, Johannes, Welz, Armin, Bahlmann, Jens, Griese, Eberhard, Lê, Trong Phi, Hebe, Joachim, Nürnberg, Jan-Hendrik, Magsaam, Annette, Müller, Ronald, Potthoff, Ludger, Voigt, Renate, Krüger, Tim, Gerleve, Hubert, Kleideiter, Ulrich, Schneider-Kulla, Dirk, Feil, Elmo, Menke, Thomas, Lehn, Martin, Grohmann, Martina, Tomczak, Helge, Krogmann, Otto N., Tarusinov, Gleb, Scheld, Michael, Mayatepek, Ertan, Pillekamp, Frank, Lichtenberg, Artur, Terpeluk, Christiane, von Jan, Veronika, Dittrich, Sven, Gundlach, Ulrike, Cesnjevar, Robert, Neudorf, Ulrich, Morf, Geert, Esmaeili, Anoosh, Backhoff, Stephan, Stiller, Brigitte, Beyersdorf, Friedhelm, Kroll, Johannes, Wildberg, Anke, Siaplaouras, Jannos, Masri-Zada, Antje, Jux, Christian, Böning, Andreas, Akintürk, Hakan, Paul, Thomas, Tirilomis, Theodor, Schürer, Gabriele, Hartmann, Johannes, Grabitz, Ralph, Liebaug, Uta, Rotzsch, Claudius, Kozlik-Feldmann, Rainer, Sachweh, Jörg, Riso, Arlindo, Petersen, Volker, Friedrich, Bernd, Schlobohm, Otmar, Beerbaum, Philipp, Böthig, Dietmar, Horke, Alexander, Bauersachs, Johann, Westhoff-Bleck, Mechthild, Gorenflo, Matthias, Karck, Matthias, Loukanov, Tsvetomir, Sebening, Christian, Schrüfer, Hermann, Wilken, Martin, Abdul-Khaliq, Hashim, Rädle-Hurst, Tanja, Rentzsch, Axel, Schäfers, Hans-Joachim, Reichert, Hagen, Kriebel, Thomas, Boysen, Arnulf, Kramer, Hans-Heiner, Cremer, Joachim Thomas, Scheewe, Jens, Buchholz-Berdau, Regina, Möller, Peter, Ram, Wolfgang, Brockmeier, Konrad, Bennink, Gerardus B.W.E., Gillor, Alex, Niehues, Tim, Terhoeven, Peter, Leidig, Steffen, Dähnert, Ingo, Kinzel, Peter, Kostelka, Martin, Kändler, Liane, Bethge, Martin, Köster, Stefan, Schröder, Christoph, Karstedt, Jens, Seitz, Uwe, Kampmann, Christoph, Vahl, Christian-Friedrich, Stahl, Frank, Barth, Helmut, Müller-Scholden, Joachim, Ewert, Peter, Hager, Alfred, Kaemmerer, Harald, Nagdyman, Nicole, Schoetzau, Jörg, Tutarel, Oktay, Lange, Rüdiger, Haas, Nikolaus A., Hakami, Lale, Hauser, Michael, Roithmaier, Alexander, Kehl, Hans Gerd, Malec, Edward, Baumgartner, Helmut, Diller, Gerhard, Bahle, Roswitha, Hofner, Gerald, Zink, Stefan, Reif, Roland, Parlasca, Christoph, Freund, Matthias W., Schumacher, Michael, Darrelmann, Christine, Motz, Reinald, Willmann, Olaf, Schmiedl, Norbert, Quick, Peter, Hillebrand, Dirk, Hirsemann, Petra, Eiselt, Stephan Michele, Nekarda, Torsten, Eberhard, Michael, Schneider, Martin, Asfour, Boulos, Baier, Georg, Uhlemann, Frank, Scheid, Michael, Beyer, Alexander, Binz, Gudrun, Teufel, Thomas, Handke, Ronald-Peter, Hofbeck, Michael, Kaulitz, Renate, Sieverding, Ludger, Schlensak, Christian, Apitz, Christian, Kupferschmid, Christoph, Holtvogt, Jürgen, Wippermann, Carl-Friedrich, Heusch, Andreas, Wirbelauer, Johannes, Brosi, Wolfgang, Poryo, Martin, Paes, Laura Antonia, Pickardt, Thomas, Bauer, Ulrike M.M., Meyer, Sascha, and Wagenpfeil, Stefan

Published
2018
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15. Myocarditis and sports in the young: data from a nationwide registry on myocarditis—“MYKKE-Sport”

Author

Schöffl, Isabelle, primary, Holler, Sophia, additional, Dittrich, Sven, additional, Pickardt, Thomas, additional, Opgen-Rhein, Bernd, additional, Boehne, Martin, additional, Wannenmacher, Bardo, additional, Reineke, Katja, additional, Wiegand, Gesa, additional, Hecht, Tobias, additional, Kaestner, Michael, additional, Messroghli, Daniel, additional, Schubert, Stephan, additional, Seidel, Franziska, additional, and Weigelt, Annika, additional

Published
2023
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16. Kiosk 6R-FC-03 - Spatially Resolved Radiomics Feature Signatures in LGE MRI in Children and Adolescents with Myocarditis – Observations From the Multicenter Registry MYKKE

Author

Laube, Ann, Huellebrand, Markus, Ter-Minassian, Léa, Schwarzkopf, Eicke, Opgen-Rhein, Bernd, Rolfs, Nele, Anderheiden, Felix, Wannenmacher, Bardo, Wiegand, Gesa, Boehne, Martin, Uden, Theodor, Reineker, Katja, Rentzsch, Axel, Fischer, Marcus, Kaestner, Michael, Hecht, Tobias, Foth, Rudi, Ruf, Bettina, Pickardt, Thomas, Schubert, Stephan, Messroghli, Daniel, Seidel, Franziska, and Hennemuth, Anja

Published
2024
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18. Myocarditis and sports in the young: data from a nationwide registry on myocarditis—'MYKKE-Sport'

Author

Schöffl, Isabelle, Holler, Sophia, Dittrich, Sven, Pickardt, Thomas, Opgen-Rhein, Bernd, Boehne, Martin, Wannenmacher, Bardo, Reineke, Katja, Wiegand, Gesa, Hecht, Tobias, Kaestner, Michael, Messroghli, Daniel, Schubert, Stephan, Seidel, Franziska, and Weigelt, Annika

Subjects
ddc:610
Abstract

Background Myocarditis represents one of the most common causes of Sudden Cardiac Death in children. Myocardial involvement during a viral infection is believed to be higher as a consequence of intensive exertion. Recommendations for return to sports are based on cohort and case studies only. This study aims to investigate the relationship between physical activity and myocarditis in the young. Patient Every patient in the MYKKE registry fulfilling criteria for suspicion of myocarditis was sent a questionnaire regarding the physical activity before, during and after the onset of myocarditis. Method This study is a subproject within the MYKKE registry, a multicenter registry for children and adolescents with suspected myocarditis. The observation period for this analysis was 93 months (September 2013–June 2021). Anamnestic, cardiac magnetic resonance images, echocardiography, biopsy and laboratory records from every patient were retrieved from the MYKKE registry database. Results 58 patients (mean age 14.6 years) were enrolled from 10 centers. Most patients participated in curricular physical activity and 36% in competitive sports before the onset of myocarditis. There was no significant difference of heart function at admission between the physically active and inactive subjects (ejection fraction of 51.8 ± 8.6% for the active group vs. 54.4 ± 7.7% for the inactive group). The recommendations regarding the return to sports varied widely and followed current guidelines in 45%. Most patients did not receive an exercise test before returning to sports. Conclusion Sports before the onset of myocarditis was not associated with a more severe outcome. There is still a discrepancy between current literature and actual recommendations given by health care providers. The fact that most participants did not receive an exercise test before being cleared for sports represents a serious omission.

Published
2023

19. Arterial tissue transcriptional profiles associate with tissue remodeling and cardiovascular phenotype in children with end-stage kidney disease

Author

Freise, Christian, Schaefer, Betti, Bartosova, Maria, Bayazit, Aysun, Bauer, Ulrike, Pickardt, Thomas, Berger, Felix, Rasmussen, Lars Melholt, Jensen, Pia Søndergaard, Laube, Guido, Mencarelli, Francesca, Arbeiter, Klaus, Büscher, Rainer, Habbig, Sandra, Möller, Kristina, Kirchner, Marietta, Schaefer, Franz, Schmitt, Claus Peter, and Querfeld, Uwe

Published
2019
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21. IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination

Author

Thurner, Lorenz, primary, Kessel, Christoph, additional, Fadle, Natalie, additional, Regitz, Evi, additional, Seidel, Franziska, additional, Kindermann, Ingrid, additional, Lohse, Stefan, additional, Kos, Igor, additional, Tschöpe, Carsten, additional, Kheiroddin, Parastoo, additional, Kiblboeck, Daniel, additional, Hoffmann, Marie-Christin, additional, Bette, Birgit, additional, Carbon, Gabi, additional, Cetin, Onur, additional, Preuss, Klaus-Dieter, additional, Christofyllakis, Konstantinos, additional, Bittenbring, Joerg T., additional, Pickardt, Thomas, additional, Fischer, Yvan, additional, Thiele, Holger, additional, Baldus, Stephan, additional, Stangl, Karl, additional, Steiner, Stephan, additional, Gietzen, Frank, additional, Kerber, Sebastian, additional, Deneke, Thomas, additional, Jellinghaus, Stefanie, additional, Linke, Axel, additional, Ibrahim, Karim, additional, Grabmaier, Ulrich, additional, Massberg, Steffen, additional, Thilo, Christian, additional, Greulich, Simon, additional, Gawaz, Meinrad, additional, Mayatepek, Ertan, additional, Meyer-Dobkowitz, Lars, additional, Kindermann, Michael, additional, Birk, Einat, additional, Birk, Merav, additional, Lainscak, Mitja, additional, Foell, Dirk, additional, Lepper, Philipp M., additional, Bals, Robert, additional, Krawczyk, Marcin, additional, Mevorach, Dror, additional, Hasin, Tal, additional, Keren, Andre, additional, Kabesch, Michael, additional, Abdul-Khaliq, Hashim, additional, Smola, Sigrun, additional, Bewarder, Moritz, additional, Thurner, Bernhard, additional, Böhm, Michael, additional, Pfeifer, Jochen, additional, and Klingel, Karin, additional

Published
2022
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22. Pathogenic Variants in Cardiomyopathy Disorder Genes Underlie Pediatric Myocarditis—Further Impact of Heterozygous Immune Disorder Gene Variants?

Author

Seidel, Franziska, primary, Laser, Kai Thorsten, additional, Klingel, Karin, additional, Dartsch, Josephine, additional, Theisen, Simon, additional, Pickardt, Thomas, additional, Holtgrewe, Manuel, additional, Gärtner, Anna, additional, Berger, Felix, additional, Beule, Dieter, additional, Milting, Hendrik, additional, Schubert, Stephan, additional, Klaassen, Sabine, additional, and Kühnisch, Jirko, additional

Published
2022
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24. Somatic Development in Children with Congenital Heart Defects

Author

Poryo, Martin, Paes, Laura Antonia, Pickardt, Thomas, Bauer, Ulrike M.M., Meyer, Sascha, Wagenpfeil, Stefan, Abdul-Khaliq, Hashim, Kerst, Gunter, Vazquez-Jimenez, Jaime F., Gkalpakiotis, Dimitrios, Schedifka, Andrea, Buheitel, Gernot, Streble, Joachim, II, Kececioglu, Deniz, Sandica, Eugen, Trusen, Burkhard, Berger, Felix, Miera, Oliver, Ovroutski, Stanislav, Peters, Björn, Schmitt, Katharina, Schubert, Stephan, Photiadis, Joachim, Opgen-Rhein, Bernd, Weiss, Katja, Berns, Christoph, Blumenthal-Barby, Carl-Christian, Boeckel, Thomas, Krusche, Susanne, Busse, Jürgen, Kästner, Andreas, Koch, Heike, Köpcke, Christian, Streichan, Frank, Timme, Jens, Franzbach, Birgit, Senft, Gabriela, Beyer, Frank, Winter, Klaus, Breuer, Johannes, Welz, Armin, Bahlmann, Jens, Griese, Eberhard, Lê, Trong Phi, Hebe, Joachim, Nürnberg, Jan-Hendrik, Magsaam, Annette, Müller, Ronald, Potthoff, Ludger, Voigt, Renate, Krüger, Tim, Gerleve, Hubert, Kleideiter, Ulrich, Schneider-Kulla, Dirk, Feil, Elmo, Menke, Thomas, Lehn, Martin, Grohmann, Martina, Tomczak, Helge, Krogmann, Otto N., Tarusinov, Gleb, Scheld, Michael, Mayatepek, Ertan, Pillekamp, Frank, Lichtenberg, Artur, Terpeluk, Christiane, von Jan, Veronika, Dittrich, Sven, Gundlach, Ulrike, Cesnjevar, Robert, Neudorf, Ulrich, Morf, Geert, Esmaeili, Anoosh, Backhoff, Stephan, Stiller, Brigitte, Beyersdorf, Friedhelm, Kroll, Johannes, Wildberg, Anke, Siaplaouras, Jannos, Masri-Zada, Antje, Jux, Christian, Böning, Andreas, Akintürk, Hakan, Paul, Thomas, Tirilomis, Theodor, Schürer, Gabriele, Hartmann, Johannes, Grabitz, Ralph, Liebaug, Uta, Rotzsch, Claudius, Kozlik-Feldmann, Rainer, Sachweh, Jörg, Riso, Arlindo, Petersen, Volker, Friedrich, Bernd, Schlobohm, Otmar, Beerbaum, Philipp, Böthig, Dietmar, Horke, Alexander, Bauersachs, Johann, Westhoff-Bleck, Mechthild, Gorenflo, Matthias, Karck, Matthias, Loukanov, Tsvetomir, Sebening, Christian, Schrüfer, Hermann, Wilken, Martin, Abdul-Khaliq, Hashim, Rädle-Hurst, Tanja, Rentzsch, Axel, Schäfers, Hans-Joachim, Reichert, Hagen, Kriebel, Thomas, Boysen, Arnulf, Kramer, Hans-Heiner, Cremer, Joachim Thomas, Scheewe, Jens, Buchholz-Berdau, Regina, Möller, Peter, Ram, Wolfgang, Brockmeier, Konrad, Bennink, Gerardus B.W.E., Gillor, Alex, Niehues, Tim, Terhoeven, Peter, Leidig, Steffen, Dähnert, Ingo, Kinzel, Peter, Kostelka, Martin, Kändler, Liane, Bethge, Martin, Köster, Stefan, Schröder, Christoph, Karstedt, Jens, Seitz, Uwe, Kampmann, Christoph, Vahl, Christian-Friedrich, Stahl, Frank, Barth, Helmut, Müller-Scholden, Joachim, Ewert, Peter, Hager, Alfred, Kaemmerer, Harald, Nagdyman, Nicole, Schoetzau, Jörg, Tutarel, Oktay, Lange, Rüdiger, Haas, Nikolaus A., Hakami, Lale, Hauser, Michael, Roithmaier, Alexander, Kehl, Hans Gerd, Malec, Edward, Baumgartner, Helmut, Diller, Gerhard, Bahle, Roswitha, Hofner, Gerald, Zink, Stefan, Reif, Roland, Parlasca, Christoph, Freund, Matthias W., Schumacher, Michael, Darrelmann, Christine, Motz, Reinald, Willmann, Olaf, Schmiedl, Norbert, Quick, Peter, Hillebrand, Dirk, Hirsemann, Petra, Eiselt, Stephan Michele, Nekarda, Torsten, Eberhard, Michael, Schneider, Martin, Asfour, Boulos, Baier, Georg, Uhlemann, Frank, Scheid, Michael, Beyer, Alexander, Binz, Gudrun, Teufel, Thomas, Handke, Ronald-Peter, Hofbeck, Michael, Kaulitz, Renate, Sieverding, Ludger, Schlensak, Christian, Apitz, Christian, Kupferschmid, Christoph, Holtvogt, Jürgen, Wippermann, Carl-Friedrich, Heusch, Andreas, Wirbelauer, Johannes, and Brosi, Wolfgang

Published
2018
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26. Additional file 1 of Le Cœur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot

Author

Mîra, Anna, Lamata, Pablo, Pushparajah, Kuberan, Abraham, Georgina, Mauger, Charlène A., McCulloch, Andrew D., Omens, Jeffrey H., Bissell, Malenka M., Blair, Zach, Huffaker, Tyler, Tandon, Animesh, Engelhardt, Sandy, Koehler, Sven, Pickardt, Thomas, Beerbaum, Philipp, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Young, Alistair A., and Hussain, Tarique

Abstract

Additional file 1. Additional data.

Published
2022
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27. Additional file 2 of Le Cœur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot

Author

Mîra, Anna, Lamata, Pablo, Pushparajah, Kuberan, Abraham, Georgina, Mauger, Charlène A., McCulloch, Andrew D., Omens, Jeffrey H., Bissell, Malenka M., Blair, Zach, Huffaker, Tyler, Tandon, Animesh, Engelhardt, Sandy, Koehler, Sven, Pickardt, Thomas, Beerbaum, Philipp, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Young, Alistair A., and Hussain, Tarique

Abstract

Additional file 2: Video S1. Animations of shape variations associated with adverse outcomes.

Published
2022
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29. Cardiovascular magnetic resonance in children with suspected myocarditis: current practice and applicability of adult protocols

Author

Pitak, Barbara, primary, Opgen-Rhein, Bernd, additional, Schubert, Stephan, additional, Reineker, Katja, additional, Wiegand, Gesa, additional, Boecker, Dorothée, additional, Rentzsch, Axel, additional, Ruf, Bettina, additional, Özcan, Sevinc, additional, Wannenmacher, Bardo, additional, Pickardt, Thomas, additional, Seidel, Franziska, additional, and Messroghli, Daniel, additional

Published
2022
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30. Le CÅ“ur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot

Author

Mîra, Anna, primary, Lamata, Pablo, additional, Pushparajah, Kuberan, additional, Abraham, Georgina, additional, Mauger, Charlène A., additional, McCulloch, Andrew D., additional, Omens, Jeffrey H., additional, Bissell, Malenka M., additional, Blair, Zach, additional, Huffaker, Tyler, additional, Tandon, Animesh, additional, Engelhardt, Sandy, additional, Koehler, Sven, additional, Pickardt, Thomas, additional, Beerbaum, Philipp, additional, Sarikouch, Samir, additional, Latus, Heiner, additional, Greil, Gerald, additional, Young, Alistair A., additional, and Hussain, Tarique, additional

Published
2022
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31. Myocarditis and Sports in the Young: Data from a Nationwide Registry on Myocarditis

Author

Schöffl, Isabelle, primary, Holler, Sophia, additional, Dittrich, Sven, additional, Pickardt, Thomas, additional, Opgen-Rhein, Bernd, additional, Boehne, Martin, additional, Wannenmacher, Bardo, additional, Reineker, Katja, additional, Wiegand, Gesa, additional, Hecht, Tobias, additional, Kaestner, Michael, additional, Messroghli, Daniel, additional, Schubert, Stephan, additional, Seidel, Franziska, additional, and Weigelt, Annika, additional

Published
2022
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32. Erratum: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease (PLoS Genetics (2021) 17:7 (e1009679) DOI: 10.1371/journal.pgen.1009679)

Author

Audain, Enrique, Wilsdon, Anna, Breckpot, Jeroen, Izarzugaza, Jose M. G., Fitzgerald, Tomas W., Kahlert, Anne-Karin, Sifrim, Alejandro, Wunnemann, Florian, Perez-Riverol, Yasset, Abdul-Khaliq, Hashim, Bak, Mads, Bassett, Anne S., Benson, D. Woodrow, Berger, Felix, Daehnert, Ingo, Devriendt, Koenraad, Dittrich, Sven, Daubeney, Piers Ef, Garg, Vidu, Hackmann, Karl, Hoff, Kirstin, Hofmann, Philipp, Dombrowsky, Gregor, Pickardt, Thomas, Bauer, Ulrike, Keavney, Bernard D., Klaassen, Sabine, Kramer, Hans-Heiner, Marshall, Christian R., Milewicz, Dianna M., Lemaire, Scott, Coselli, Joseph S., Mitchell, Michael E., Tomita-Mitchell, Aoy, Prakash, Siddharth K., Stamm, Karl, Stewart, Alexandre F. R., Silversides, Candice K., Siebert, Reiner, Stiller, Brigitte, Rosenfeld, Jill A., Vater, Inga, Postma, Alex V., Caliebe, Almuth, Brook, J. David, Andelfinger, Gregor, Hurles, Matthew E., Thienpont, Bernard, Larsen, Lars Allan, Hitz, Marc-Phillip, Human Genetics, Medical Biology, ACS - Heart failure & arrhythmias, ACS - Pulmonary hypertension & thrombosis, Amsterdam Cardiovascular Sciences, and Amsterdam Reproduction & Development (AR&D)

Abstract

The thirteenth author's name is spelled incorrectly. The correct name is: D. Woodrow Benson.

Published
2021

33. Abstract 8928: Le Coeur En Sabot: Shape and Regional Function Predict Adverse Outcome in Patients with Repaired Tetralogy of Fallot

Author

Mira, Anna, primary, Lamata, Pablo, additional, Young, Alistair, additional, Pickardt, Thomas, additional, Tandon, Animesh A, additional, Sarikouch, Samir, additional, Omens, Jeff, additional, Latus, Heiner, additional, Beerbaum, Philipp B, additional, Koehler, Sven, additional, Bissell, Malenka, additional, Blair, Zachary, additional, Huffaker, Tyler, additional, Pushparajah, Kuberan, additional, Mauger, Charlene, additional, Abraham, Georgina, additional, McCulloch, Andrew, additional, Greil, Gerald, additional, Engelhardt, Sandy, additional, and Hussain, Mohammad, additional

Published
2021
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34. Unsupervised Domain Adaptation From Axial to Short-Axis Multi-Slice Cardiac MR Images by Incorporating Pretrained Task Networks

Author

Koehler, Sven, primary, Hussain, Tarique, additional, Blair, Zach, additional, Huffaker, Tyler, additional, Ritzmann, Florian, additional, Tandon, Animesh, additional, Pickardt, Thomas, additional, Sarikouch, Samir, additional, Latus, Heiner, additional, Greil, Gerald, additional, Wolf, Ivo, additional, and Engelhardt, Sandy, additional

Published
2021
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35. Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

Author

Audain, Enrique, primary, Wilsdon, Anna, additional, Breckpot, Jeroen, additional, Izarzugaza, Jose M. G., additional, Fitzgerald, Tomas W., additional, Kahlert, Anne-Karin, additional, Sifrim, Alejandro, additional, Wünnemann, Florian, additional, Perez-Riverol, Yasset, additional, Abdul-Khaliq, Hashim, additional, Bak, Mads, additional, Bassett, Anne S., additional, Benson, D. Woodrow, additional, Berger, Felix, additional, Daehnert, Ingo, additional, Devriendt, Koenraad, additional, Dittrich, Sven, additional, Daubeney, Piers EF, additional, Garg, Vidu, additional, Hackmann, Karl, additional, Hoff, Kirstin, additional, Hofmann, Philipp, additional, Dombrowsky, Gregor, additional, Pickardt, Thomas, additional, Bauer, Ulrike, additional, Keavney, Bernard D., additional, Klaassen, Sabine, additional, Kramer, Hans-Heiner, additional, Marshall, Christian R., additional, Milewicz, Dianna M., additional, Lemaire, Scott, additional, Coselli, Joseph S., additional, Mitchell, Michael E., additional, Tomita-Mitchell, Aoy, additional, Prakash, Siddharth K., additional, Stamm, Karl, additional, Stewart, Alexandre F. R., additional, Silversides, Candice K., additional, Siebert, Reiner, additional, Stiller, Brigitte, additional, Rosenfeld, Jill A., additional, Vater, Inga, additional, Postma, Alex V., additional, Caliebe, Almuth, additional, Brook, J. David, additional, Andelfinger, Gregor, additional, Hurles, Matthew E., additional, Thienpont, Bernard, additional, Larsen, Lars Allan, additional, and Hitz, Marc-Phillip, additional

Published
2021
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36. Pathogenic Variants Associated With Dilated Cardiomyopathy Predict Outcome in Pediatric Myocarditis

Author

Seidel, Franziska, primary, Holtgrewe, Manuel, additional, Al-Wakeel-Marquard, Nadya, additional, Opgen-Rhein, Bernd, additional, Dartsch, Josephine, additional, Herbst, Christopher, additional, Beule, Dieter, additional, Pickardt, Thomas, additional, Klingel, Karin, additional, Messroghli, Daniel, additional, Berger, Felix, additional, Schubert, Stephan, additional, Kühnisch, Jirko, additional, and Klaassen, Sabine, additional

Published
2021
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37. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

Author

Audain, Enrique, primary, Wilsdon, Anna, additional, Breckpot, Jeroen, additional, Izarzugaza, Jose M. G., additional, Fitzgerald, Tomas W., additional, Kahlert, Anne-Karin, additional, Sifrim, Alejandro, additional, Wünnemann, Florian, additional, Perez-Riverol, Yasset, additional, Abdul-Khaliq, Hashim, additional, Bak, Mads, additional, Bassett, Anne S., additional, Benson, Woodrow D., additional, Berger, Felix, additional, Daehnert, Ingo, additional, Devriendt, Koenraad, additional, Dittrich, Sven, additional, Daubeney, Piers EF, additional, Garg, Vidu, additional, Hackmann, Karl, additional, Hoff, Kirstin, additional, Hofmann, Philipp, additional, Dombrowsky, Gregor, additional, Pickardt, Thomas, additional, Bauer, Ulrike, additional, Keavney, Bernard D., additional, Klaassen, Sabine, additional, Kramer, Hans-Heiner, additional, Marshall, Christian R., additional, Milewicz, Dianna M., additional, Lemaire, Scott, additional, Coselli, Joseph S., additional, Mitchell, Michael E., additional, Tomita-Mitchell, Aoy, additional, Prakash, Siddharth K., additional, Stamm, Karl, additional, Stewart, Alexandre F. R., additional, Silversides, Candice K., additional, Siebert, Reiner, additional, Stiller, Brigitte, additional, Rosenfeld, Jill A., additional, Vater, Inga, additional, Postma, Alex V., additional, Caliebe, Almuth, additional, Brook, J. David, additional, Andelfinger, Gregor, additional, Hurles, Matthew E., additional, Thienpont, Bernard, additional, Larsen, Lars Allan, additional, and Hitz, Marc-Phillip, additional

Published
2021
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38. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

Author

Audain, Enrique, Wilsdon, Anna, Breckpot, Jeroen, Izarzugaza, Jose M.G., Fitzgerald, Tomas W., Kahlert, Anne Karin, Sifrim, Alejandro, Wünnemann, Florian, Perez-Riverol, Yasset, Abdul-Khaliq, Hashim, Bak, Mads, Bassett, Anne S., Benson, Woodrow D., Berger, Felix, Daehnert, Ingo, Devriendt, Koenraad, Dittrich, Sven, Daubeney, Piers E.F., Garg, Vidu, Hackmann, Karl, Hoff, Kirstin, Hofmann, Philipp, Dombrowsky, Gregor, Pickardt, Thomas, Bauer, Ulrike, Keavney, Bernard D., Klaassen, Sabine, Kramer, Hans Heiner, Marshall, Christian R., Milewicz, Dianna M., Lemaire, Scott, Coselli, Joseph S., Mitchell, Michael E., Tomita-Mitchell, Aoy, Prakash, Siddharth K., Stamm, Karl, Stewart, Alexandre F.R., Silversides, Candice K., Siebert, Reiner, Stiller, Brigitte, Rosenfeld, Jill A., Vater, Inga, Postma, Alex V., Caliebe, Almuth, Brook, J. David, Andelfinger, Gregor, Hurles, Matthew E., Thienpont, Bernard, Larsen, Lars Allan, Hitz, Marc Phillip, Audain, Enrique, Wilsdon, Anna, Breckpot, Jeroen, Izarzugaza, Jose M.G., Fitzgerald, Tomas W., Kahlert, Anne Karin, Sifrim, Alejandro, Wünnemann, Florian, Perez-Riverol, Yasset, Abdul-Khaliq, Hashim, Bak, Mads, Bassett, Anne S., Benson, Woodrow D., Berger, Felix, Daehnert, Ingo, Devriendt, Koenraad, Dittrich, Sven, Daubeney, Piers E.F., Garg, Vidu, Hackmann, Karl, Hoff, Kirstin, Hofmann, Philipp, Dombrowsky, Gregor, Pickardt, Thomas, Bauer, Ulrike, Keavney, Bernard D., Klaassen, Sabine, Kramer, Hans Heiner, Marshall, Christian R., Milewicz, Dianna M., Lemaire, Scott, Coselli, Joseph S., Mitchell, Michael E., Tomita-Mitchell, Aoy, Prakash, Siddharth K., Stamm, Karl, Stewart, Alexandre F.R., Silversides, Candice K., Siebert, Reiner, Stiller, Brigitte, Rosenfeld, Jill A., Vater, Inga, Postma, Alex V., Caliebe, Almuth, Brook, J. David, Andelfinger, Gregor, Hurles, Matthew E., Thienpont, Bernard, Larsen, Lars Allan, and Hitz, Marc Phillip

Abstract

Numerous genetic studies have established a role for rare genomic variants in Congenital Heart Disease (CHD) at the copy number variation (CNV) and de novo variant (DNV) level. To identify novel haploinsufficient CHD disease genes, we performed an integrative analysis of CNVs and DNVs identified in probands with CHD including cases with sporadic thoracic aortic aneurysm. We assembled CNV data from 7,958 cases and 14,082 controls and performed a gene-wise analysis of the burden of rare genomic deletions in cases versus controls. In addition, we performed variation rate testing for DNVs identified in 2,489 parentoffspring trios. Our analysis revealed 21 genes which were significantly affected by rare CNVs and/or DNVs in probands. Fourteen of these genes have previously been associated with CHD while the remaining genes (FEZ1, MYO16, ARID1B, NALCN, WAC, KDM5B and WHSC1) have only been associated in small cases series or show new associations with CHD. In addition, a systems level analysis revealed affected protein-protein interaction networks involved in Notch signaling pathway, heart morphogenesis, DNA repair and cilia/centrosome function. Taken together, this approach highlights the importance of re-analyzing existing datasets to strengthen disease association and identify novel disease genes and pathways. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Published
2021

41. Clinical Characteristics and Outcome of Biopsy-Proven Myocarditis in Children – Results of the German Prospective Multicentre Registry 'MYKKE'

Author

Seidel, Franziska, primary, Opgen-Rhein, Bernd, additional, Rentzsch, Axel, additional, Boehne, Martin, additional, Wannenmacher, Bardo, additional, Boecker, Dorotheé, additional, Reineker, Katja, additional, Grafmann, Maria, additional, Wiegand, Gesa, additional, Hecht, Tobias, additional, Kiski, Daniela, additional, Fischer, Marcus, additional, Papakostas, Konstantin, additional, Ruf, Bettina, additional, Kramp, Jennifer, additional, Khalil, Marcus, additional, Kaestner, Michael, additional, Steinmetz, Michael, additional, Fischer, Gunther, additional, Özcan, Sevinc, additional, Freudenthal, Noa, additional, Schweigmann, Ulrich, additional, Hellwig, Regina, additional, Pickardt, Thomas, additional, Klingel, Karin, additional, Messroghli, Daniel, additional, and Schubert, Stephan, additional

Published
2021
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45. How well do U-Net-based segmentation trained on adult cardiac magnetic resonance imaging data generalize to rare congenital heart diseases for surgical planning?

Author

Koehler, Sven, primary, Tandon, Animesh, additional, Hussain, Tarique, additional, Latus, Heiner, additional, Pickardt, Thomas, additional, Sarikouch, Samir, additional, Beerbaum, Philipp, additional, Greil, Gerald, additional, Engelhardt, Sandy, additional, and Wolf, Ivo, additional

Published
2020
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48. Additional file 5: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Subjects
animal structures, embryonic structures, human activities
Abstract

Figure S5. Regulatory features and associations to UCSC gene regions among 168 differentially methylated atrial-ventricular CpGs. Regulatory features and UCSC gene regions of all 168 CpGs (‘overall’), of ventricular-hypo/atrial-hypermethylated CpGs (‘ventricle hypo/ atrium hyper’ n = 44 CpGs) and ventricular-hyper/atrial-hypomethylated CpGs (‘ventricle hyper/ atrium hypo’ n = 124 CpGs) of 450K array analysis are depicted. Highest percentage of overlap with regulatory features (ENCODE) could be shown in enhancer elements (ENH) (50% (84/168) of CpGs), CpG island shores (29% (48/168) of CpGs) and DNAse I hypersensitivity sites (DHS) with 14% (24/168). Associations to UCSC gene regions showed highest proportion in gene bodies (30% (51/168) of CpGs). Besides CpG island shores, which showed a higher proportion in ‘ventricle hypo/ atrium hyper’-CpGs as compared to ‘ventricle hyper/ atrium hypo’-CpGs, all other regulatory features or gene regions did not show any difference between heart tissues. Shore, 0–2 kb from of UCSC CpG island; shelf, 2–4 kb from UCSC CpG island. TSS200, 0–200 bases upstream of the transcriptional start site, TSS1500, 0.2–1.5 kb upstream of the TSS. DMR: differentially methylated region (RDMR: DMR in reprogrammed cells). Gene regions of the CpGs are given according to Illumina’s 450K array classifications and UCSC classifications. (PDF 299 kb)

Published
2019
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49. Additional file 6: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Abstract

Figure S6. Transcription factor binding sites subject to differential DNA methylation among 168 CpGs. Analysis of 168 differentially methylated CpGs between atrial and ventricular heart tissue revealed an overlap of 54% (90/168) of CpG loci being associated to TFBSs in various cell lines from ChIP-seq experiments performed by ENCODE (Factorbook Motifs [32]). The ten most common TFs showing TFBSs among the 168 CpGs are labelled: POLR2A, EZH2, EP300, GATA2, FOS, RUNX3, CEBPB, TCF7L2, MAX and TEAD4. Only TFBSs with Cluster Scores (out of 1000) >â 300 are listed (Additional file 15: Table S2). (PDF 354 kb)

Published
2019
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50. Additional file 1: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Subjects
cardiovascular system
Abstract

Figure S1. Principal component analysis of cardiac disease type among 448,814 loci. The segregation of β-values of 448,814 loci from 49 different cardiac tissue samples (mean values of biological replicates, for detailed information see Additional file 14: Table S1) that were subjected to 450K array DNA methylation analysis is depicted. Cardiac disease types are given in different colours and shapes: AVSD (red round dots), DCM (yellow triangles), HLHS (green solid squares), HRHS (blue crosses), LV-Aneurysm (purple squares). No differences in DNA methylation could be observed between different types of cardiac disease. (PDF 1442 kb)

Published
2019
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