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128 results on '"Piccolo, Giuseppe"'

1. Determinants of immunosuppressive therapy in renal transplant recipients: an Italian observational study (the CESIT project)

Author

Rosa, Alessandro C., Finocchietti, Marco, Agabiti, Nera, Menè, Paolo, Bracaccia, Maria Elena, Bellini, Arianna, Massari, Marco, Spila Alegiani, Stefania, Masiero, Lucia, Bedeschi, Gaia, Cardillo, Massimo, Lucenteforte, Ersilia, Piccolo, Giuseppe, Leoni, Olivia, Ferroni, Eliana, Pierobon, Silvia, Nordio, Maurizio, Ledda, Stefano, Garau, Donatella, Davoli, Marina, Addis, Antonio, and Belleudi, Valeria

Published
2023
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11. Determinants of immunosuppressive therapy in renal transplant recipients: an Italian observational study (the CESIT project)

Author

Rosa, Alessandro C., primary, Finocchietti, Marco, additional, Agabiti, Nera, additional, Menè, Paolo, additional, Bracaccia, Maria Elena, additional, Bellini, Arianna, additional, Massari, Marco, additional, Alegiani, Stefania Spila, additional, Masiero, Lucia, additional, Bedeschi, Gaia, additional, Cardillo, Massimo, additional, Lucenteforte, Ersilia, additional, Piccolo, Giuseppe, additional, Leoni, Olivia, additional, Ferroni, Eliana, additional, Pierobon, Silvia, additional, Nordio, Maurizio, additional, Ledda, Stefano, additional, Garau, Donatella, additional, Davoli, Marina, additional, Addis, Antonio, additional, and Belleudi, Valeria, additional

Published
2023
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13. Effectiveness and safety of immunosuppressive regimens used as maintenance therapy in kidney transplantation: The CESIT study.

Author

Bellini, Arianna, Finocchietti, Marco, Rosa, Alessandro Cesare, Nordio, Maurizio, Ferroni, Eliana, Massari, Marco, Spila Alegiani, Stefania, Masiero, Lucia, Bedeschi, Gaia, Cardillo, Massimo, Lucenteforte, Ersilia, Piccolo, Giuseppe, Leoni, Olivia, Pierobon, Silvia, Ledda, Stefano, Garau, Donatella, Davoli, Marina, Addis, Antonio, and Belleudi, Valeria

Subjects
KIDNEY transplantation, IMMUNOSUPPRESSIVE agents, CYCLOSPORINE, TACROLIMUS, RAPAMYCIN
Abstract

Maintenance immunosuppressive therapy used in kidney transplantation typically involves calcineurin inhibitors, such as tacrolimus or cyclosporine, in combination with mycophenolate or mechanistic target of rapamycin (mTORi) with or without corticosteroids. An Italian retrospective multicentre observational study was conducted to investigate the risk-benefit profile of different immunosuppressive regimens. We identified all subjects who underwent kidney transplant between 2009 and 2019, using healthcare claims data. Patients on cyclosporine and tacrolimus-based therapies were matched 1:1 based on propensity score, and effectiveness and safety outcomes were compared using Cox models (HR; 95%CI). Analyses were also conducted comparing mTORi versus mycophenolate among tacrolimus-treated patients. Patients treated with cyclosporine had a higher risk of rejection or graft loss (HR:1.69; 95%CI:1.16–2.46) and a higher incidence of severe infections (1.25;1.00–1.55), but a lower risk of diabetes (0.66;0.47–0.91) compared to those treated with tacrolimus. Among tacrolimus users, mTORi showed non-inferiority to MMF in terms of mortality (1.01;0.68–1.62), reject/graft loss (0.61;0.36–1.04) and severe infections (0.76;0.56–1.03). In a real-life setting, tacrolimus-based immunosuppressive therapy appeared to be superior to cyclosporine in reducing rejection and severe infections, albeit with an associated increased risk of diabetes. The combination of tacrolimus and mTORi may represent a valid alternative to the combination with mycophenolate, although further studies are needed to confirm this finding. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Temporal and spatial variability of immunosuppressive therapies in transplant patients: An observational study in Italy

Author

Marino, Maria Lucia, primary, Rosa, Alessandro C., additional, Finocchietti, Marco, additional, Bellini, Arianna, additional, Poggi, Francesca R., additional, Massari, Marco, additional, Spila Alegiani, Stefania, additional, Masiero, Lucia, additional, Ricci, Andrea, additional, Bedeschi, Gaia, additional, Puoti, Francesca, additional, Cardillo, Massimo, additional, Pierobon, Silvia, additional, Nordio, Maurizio, additional, Ferroni, Eliana, additional, Zanforlini, Martina, additional, Piccolo, Giuseppe, additional, Leoni, Olivia, additional, Ledda, Stefano, additional, Carta, Paolo, additional, Garau, Donatella, additional, Lucenteforte, Ersilia, additional, Davoli, Marina, additional, Addis, Antonio, additional, and Belleudi, Valeria, additional

Published
2023
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16. Interaction between calcineurin inhibitors and IL-28B rs12979860 C>T polymorphism and response to treatment for post-transplant recurrent hepatitis C

Author

Cmet, Sara, Cussigh, Annarosa, Viganò, Raffaella, Airoldi, Aldo, Pasulo, Luisa, Colpanij, Maria, De Martin, Eleonora, Gambato, Martina, Rigamonti, Cristina, Bitetto, Davide, De Feo, Tullia, Mantovani, Martina, Falleti, Edmondo, Fabris, Carlo, Belli, Luca Saverio, Fagiuoli, Stefano, Burra, Patrizia, Piccolo, Giuseppe, Donato, Maria Francesca, and Toniutto, Pierluigi

Published
2013
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18. The impact of the COVID-19 outbreak on liver transplantation programs in Northern Italy

Author

Maggi, Umberto, De Carlis, Luciano, Yiu, Daniel, Colledan, Michele, Regalia, Enrico, Rossi, Giorgio, Angrisani, Marco, Consonni, Dario, Fornoni, Gianluca, Piccolo, Giuseppe, DeFeo, T. Maria, Maggi, U, De Carlis, L, Yiu, D, Colledan, M, Regalia, E, Rossi, G, Angrisani, M, Consonni, D, Fornoni, G, Piccolo, G, and Defeo, T

Subjects
Male, Pediatrics, Basiliximab, medicine.medical_treatment, 030230 surgery, Liver transplantation, COVID-19 Testing, 0302 clinical medicine, Epidemiology, Immunology and Allergy, Pharmacology (medical), Young adult, Mortality rate, infection and infectious agents – viral, critical care/intensive care management, Middle Aged, Prognosis, Tissue Donors, Treatment Outcome, Italy, Female, epidemiology, Coronavirus Infections, medicine.drug, Adult, organ allocation, medicine.medical_specialty, Tissue and Organ Procurement, Adolescent, Pneumonia, Viral, Brief Communication, clinical research/practice, End Stage Liver Disease, Betacoronavirus, Young Adult, 03 medical and health sciences, medicine, Humans, Pandemics, Aged, Transplantation, Clinical Laboratory Techniques, SARS-CoV-2, business.industry, bronchoalveolar lavage (BAL), COVID-19, Outbreak, Postoperative complication, Liver Transplantation, COVID-19, Liver, Transplantation, business, liver transplantation/hepatology, Follow-Up Studies
Abstract

In January 2020, Novel Coronavirus Disease 2019 (COVID-19) resulted in a global pandemic, creating uncertainty towards the management of Liver Transplantation (LT) programmes. Lombardy has been the most affected region in Italy: The current mortality rate of COVID-19 patients is 18,3% (10022 deaths) (April 10th) with hospitals in Lombardy having to expand the total number of ICU beds from 724 to 1381 to accommodate infected patients. There has been a drastic decrease in liver donors. From February 23rd until April 10th, 17 LTs were performed in Lombardy. Mean donor age was 49 years (range 18-74) whereas mean recipient age was 55 (13-69); mean MELD Score was 12 (6-24). All donors underwent screening for SARS CoV-2 prior to LT. Two patients tested positive after LT, and one patient died for COVID on POD 30. 16 patients are alive after an average of 30 days post LT (range 3-46). 10 patients have been discharged. This study has found no specific reason concerning the safety of recipients, to stop liver transplantation programmes. Several Key-lessons from our experience are reported. However, due to the complex circumstances which surround the viral outbreak, the cessation or a reduction in LT activity is a pragmatic requirement.

Published
2020
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20. Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death

Author

Gregorini, Marilena, primary, Ticozzelli, Elena, additional, Abelli, Massimo, additional, Grignano, Maria A., additional, Pattonieri, Eleonora F., additional, Giacomoni, Alessandro, additional, De Carlis, Luciano, additional, Dell’Acqua, Antonio, additional, Caldara, Rossana, additional, Socci, Carlo, additional, Bottazzi, Andrea, additional, Libetta, Carmelo, additional, Sepe, Vincenzo, additional, Malabarba, Stefano, additional, Manzoni, Federica, additional, Klersy, Catherine, additional, Piccolo, Giuseppe, additional, and Rampino, Teresa, additional

Published
2022
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23. The 3-T Model of Informed Consent for Nonstandard Risk Donors: A Proposal for Transplant Clinical Practice

Author

Grossi, Alessandra Agnese, primary, Nicoli, Federico, additional, De Feo, Tullia Maria, additional, Cardillo, Massimo, additional, Biffa, Gabriella, additional, Pegoraro, Renzo, additional, Petrini, Carlo, additional, Torelli, Rosanna, additional, Puoti, Francesca, additional, Rossini, Giuseppe, additional, Piccolo, Giuseppe, additional, Vesconi, Sergio, additional, Minetti, Enrico, additional, Pozzo, Barbara, additional, Vanacore, Giuseppe, additional, Paredes, David, additional, Grossi, Paolo Antonio, additional, and Picozzi, Mario, additional

Published
2021
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24. Incidence and outcome of SARS-CoV-2 infection on solid organ transplantation recipients: A nationwide population-based study

Author

Trapani, Silvia, Masiero, Lucia, Puoti, Francesca, Rota, Maria C., Del Manso, Martina, Lombardini, Letizia, Riccardo, Flavia, Amoroso, Antonio, Pezzotti, Patrizio, Grossi, Paolo A., Brusaferro, Silvio, Cardillo, Massimo, Maccarone, Daniela, Giacon, Bruno, Saracino, Angelo, Mancini, Pellegrino, Corcione, Antonio, Sangiorgi, Gabriela, Peressutti, Roberto, Torlone, Nicola, Castiglione, Andrea G., Piccolo, Giuseppe, De Pace, Francesca, Besso, Federico G., Gesualdo, Loreto, D’Antonio, Lorenzo, Battaglia, Giorgio, Peris, Adriano, Pilati, Lucia, Dovas, Atanassios, and Feltrin, Giuseppe

Subjects
medicine.medical_specialty, infection and infectious agents, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), clinical research/practice, epidemiology, health services and outcomes research, infectious disease, organ transplantation in general, patient survival, Humans, Incidence, Italy, SARS-CoV-2, Transplant Recipients, COVID-19, Organ Transplantation, Age adjustment, Rate ratio, Organ transplantation, Internal medicine, Epidemiology, medicine, Immunology and Allergy, Cumulative incidence, Pharmacology (medical), Transplantation, business.industry, Incidence (epidemiology), Odds ratio, business
Abstract

Since February 21 2020, when the Italian National Institute of Health (Istituto Superiore di Sanità-ISS) reported the first autochthonous case of infection, a dedicated surveillance system for SARS-CoV-2-positive (COVID+) cases has been created in Italy. These data were cross-referenced with those inside the Information Transplant System in order to assess the cumulative incidence (CI) and the outcome of SARS-COV-2 infection in solid organ transplant recipients (SOTRs) who are assumed to be most at risk. We compared our results with those of COVID+ nontransplanted patients (Non-SOTRs) with follow-up through September 30, 2020. The CI of SARS-CoV-2 infection in SOTRs was 1.02%, higher than in COVID+ Non-SOTRs (0.4%, p .05) with a greater risk in the Lombardy region (2.89%). The CI by type of organ transplant was higher for heart (CI 1.57%, incidence rate ratio [IRR] 1.36) and lower for liver (CI 0.63%, IRR 0.54). The 60-day CI of mortality was 30.6%, twice as much that of COVID+ Non-SOTRs (15.4%) with a 60-day gender and age adjusted odds ratio (adjusted-OR) of 3.83 for COVID+ SOTRs (95% confidence interval [3.03-4.85]). The lowest 60-day adjusted-OR was observed in liver SOTRs (OR 0.46, 95% confidence interval [0.25-0.86]). More detailed studies on disease management and evolution will be necessary in these patients at greater risk of COVID-19.

Published
2021

30. La trasformazione dell’impianto fortificato della città di Nola tra Quattrocento e Cinquecento

Author

Mollo, Giuseppe, Piccolo, Giuseppe, Mollo, Giuseppe, and Piccolo, Giuseppe

Abstract

[EN] The study relating to the town walls of Nola (a city near Naples) is one of the most interesting among those about the Neapolitan military architecture between the fifteenth and sixteenth centuries. The building phases of the defensive walls allow us to retrace two main moments of the Renaissance military architecture. It is to say, from the original and most ancient example of a puntoni struts fortifications, about which we can relate thanks to the precious and detailed Ambrogio Leone de Nola’s description made at the beginning of 1500, to the renewed defensive rampart body designed by el comendador Luis Escrivà during the Toledian period. A thorough recon of the iconographic sources, the regarding of the specialistic historiography, the contemporary theoretical assumptions and, most of all, a thorough recon of the still visible traces in the urban fabric and those emerged during the recent archeological investigations enable us to propose a structured theory about the building of the walls of Nola.

Published
2020

33. Donation after circulatory death and liver transplantation: a cohort study.

Author

Passamonti, Serena Maria, Cannavò, Antonino, Panigada, Mauro, Trunzo, Valentina, Bottazzi, Andrea, Longobardi, Antonio, Buonocore, Ruggero, Fiorattini, Andrea, Torelli, Rosanna, Piccolo, Giuseppe, and De Feo, Tullia Maria

Subjects
LIVER transplantation, COHORT analysis, POISSON regression, REGRESSION analysis, CONFIDENCE intervals
Abstract

Summary: Donations after circulatory death (DCD) are still challenging in Italy because of prolonged ischemia time (tWIT) due to the law and logistical issues. This cohort study was primarily aimed at assessing the association between successful transplantation and DCD types in the North Italy Transplant program. Adjusted risk ratios (RR) and 95% confidence intervals (CIs) for type III versus type II DCD were estimated using a Poisson regression model with a robust error variance. All consecutive DCD between 2008 and 2020 were included. Among 142 DCD, 102 were eligible for liver donation, and 96 were proposed: 68/69 (99%) and 28/33 (85%) type III and II DCD, respectively. Sixty‐nine livers were recovered, 51/68 (75%) from type III and 18/28 (64%) from type II DCD, respectively (RR: 1.18; 95% CI: 0.87–1.60). After ex‐vivo perfusion, 50/68 (74%) and 14/28 (50%) livers from type III and type II DCD were transplanted (RR: 1.49; 95% CI: 1.01–2.19). The estimate decreased after further controlling for tWIT (RR: 1.11; 95% CI: 0.55–2.24). Five patients (7.8%) experienced a PNF, 3/50 and 2/14 from type III and type II DCD, respectively. Type III DCD livers were more likely to be transplanted than type II. Warm ischemia time might explain this difference. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Social violence and migration: the emergence of traumatic traces in a Photolangage® group

Author

Lo Piccolo, Giuseppe, Sanchis Zozaya, Javier, and Katz-Gilbert, Muriel

Subjects
group, migration, violence, trauma, mediation
Abstract

In a context of social violence and great precariousness, contemporary migratory flows call into question our care devices and in particular the individual setting. The issue regarding potential traumas due to forced migration put us in front of the complexity of the clinical picture in a transcultural context. Through an original device based on the use of image mediation in a group of asylum seekers, we will try to show how the use of group therapy, on the one hand, and photographic mediation, on the other, can give a crucial contribution to foster the associative and representation processes of the affections and the underlying traumatic traces.

Published
2018

38. Filiation catastrophique et travail de mémoire après la Shoah : quand la libre réalisation de l'arbre généalogique est au service de l'historicisation

Author

Katz-Gilbert, Muriel, Bourguignon, Manon, and Lo Piccolo, Giuseppe

Abstract

Cet article se propose de montrer comment un crime de masse tel que le génocide entraîne des répercussions psychiques sur plusieurs générations, ce que l’on peut considérer comme une catastrophe de la liation. Comment s’inscrire dans un lien de liation pour écrire son propre roman des origines lorsque l’horreur vécue musèle à jamais la vie de la mémoire, de la parole et de la transmission ? C’est à travers la médiation projective de la libre réalisa- tion de l’arbre généalogique que l’article tentera d’explorer ces questions par une étude de cas. Dans l’espace intermédiaire de la rencontre, tout en respec- tant les aménagements défensifs du sujet, le travail de perlaboration se rend possible. L’article montre comment la dimension médiatrice et projective du dispositif se met au service du travail d’historicisation et de remémoration de l’histoire familiale et collective chez un descendant d’un survivant de la Shoah.

Published
2016

45. Acceptance of noninvasive computed tomography coronary angiography: for a patient-friendly medicine

Author

La Grutta, Ludovico, primary, La Grutta, Sabina, additional, Galia, Massimo, additional, Lo Piccolo, Giuseppe, additional, Gentile, Giovanni, additional, La Tona, Giuseppe, additional, Epifanio, Maria Stella, additional, Maffei, Erica, additional, Cademartiri, Filippo, additional, Lo Baido, Rosa, additional, Lagalla, Roberto, additional, and Midiri, Massimo, additional

Published
2013
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46. Interaction between calcineurin inhibitors and IL-28B rs12979860 C>T polymorphism and response to treatment for post-transplant recurrent hepatitis C

Author

Bitetto, Davide, primary, De Feo, Tullia, additional, Mantovani, Martina, additional, Falleti, Edmondo, additional, Fabris, Carlo, additional, Belli, Luca Saverio, additional, Fagiuoli, Stefano, additional, Burra, Patrizia, additional, Piccolo, Giuseppe, additional, Donato, Maria Francesca, additional, Toniutto, Pierluigi, additional, Cmet, Sara, additional, Cussigh, Annarosa, additional, Viganò, Raffaella, additional, Airoldi, Aldo, additional, Pasulo, Luisa, additional, Colpanij, Maria, additional, De Martin, Eleonora, additional, Gambato, Martina, additional, and Rigamonti, Cristina, additional

Published
2013
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47. The Self-Locating Catheter: Clinical Experience and Follow-Up

Author

Di Paolo, Nicola, primary, Capotondo, Luigi, additional, Sansoni, Enrico, additional, Romolini, Valerio, additional, Simola, Matteo, additional, Gaggiotti, Enzo, additional, Bercia, Roberto, additional, Buoncristiani, Umberto, additional, Cantù, Paola, additional, Concetti, Massimo, additional, De Vecchi, Amedeo, additional, Fatuzzo, Pasquale, additional, Giannattasio, Michele, additional, La Rosa, Roberto, additional, Lopez, Teodoro, additional, Lo Piccolo, Giuseppe, additional, Melandri, Marcello, additional, Vezzoli, Giuseppe, additional, Orazi, Ersilia, additional, Pacitti, Alfonso, additional, Ramello, Adriano, additional, Russo, Franco, additional, Napoli, Marcello, additional, and Tessarin, Maria Cristina, additional

Published
2004
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50. The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions

Author

Kukic, Predrag, Lo Piccolo, Giuseppe Mattia, Nogueira, Marcela O, Svergun, Dmitri I, Vendruscolo, Michele, Felli, Isabella C, and Pierattelli, Roberta

Subjects
Human papillomavirus 16, Protein Domains, Papillomavirus E7 Proteins, Humans, Amino Acid Sequence, Molecular Dynamics Simulation, Nuclear Magnetic Resonance, Biomolecular, 3. Good health
Abstract

When present, structural disorder makes it very challenging to characterise the conformational properties of proteins. This is particularly the case of proteins, such as the oncogene protein E7 of human papillomavirus type 16, which contain both ordered and disordered domains, and that can populate monomeric and oligomeric states under physiological conditions. Nuclear magnetic resonance (NMR) spectroscopy is emerging as a powerful method to study these complex systems, most notably in combination with molecular dynamics simulations. Here we use NMR chemical shifts and residual dipolar couplings as structural restraints in replica-averaged molecular dynamics simulations to determine the free energy landscape of E7. This landscape reveals a complex interplay between a folded but highly dynamical C-terminal domain and a disordered N-terminal domain that forms transient secondary and tertiary structures, as well as an equilibrium between a high-populated (98%) dimeric state and a low-populated (2%) monomeric state. These results provide compelling evidence of the complex conformational heterogeneity associated with the behaviour and interactions of this disordered protein associated with disease.

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