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1. Neuroimaging Findings in Mild Cognitive Impairment

Author

Massa, Federico, Bauckneht, Matteo, Peira, Enrico, Lapucci, Caterina, Picco, Agnese, Capitanio, Selene, Arnaldi, Dario, Roccatagliata, Luca, Chincarini, Andrea, Nobili, Flavio, Dierckx, Rudi A. J. O., editor, Otte, Andreas, editor, de Vries, Erik F. J., editor, van Waarde, Aren, editor, and Leenders, Klaus L., editor

Published
2021
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2. Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer’s disease

Author

Ramusino, Matteo Cotta, Garibotto, Valentina, Bacchin, Ruggero, Altomare, Daniele, Dodich, Alessandra, Assal, Frederic, Mendes, Aline, Costa, Alfredo, Tinazzi, Michele, Morbelli, Silvia D., Bauckneht, Matteo, Picco, Agnese, Dottorini, Massimo E., Tranfaglia, Cristina, Farotti, Lucia, Salvadori, Nicola, Moretti, Davide, Savelli, Giordano, Tarallo, Anna, Nobili, Flavio, Parapini, Maura, Cavaliere, Carlo, Salvatore, Elena, Salvatore, Marco, Boccardi, Marina, and Frisoni, Giovanni B

Published
2020
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3. Neuroimaging Findings in Mild Cognitive Impairment

Author

Massa, Federico, primary, Bauckneht, Matteo, additional, Peira, Enrico, additional, Lapucci, Caterina, additional, Picco, Agnese, additional, Capitanio, Selene, additional, Arnaldi, Dario, additional, Roccatagliata, Luca, additional, Chincarini, Andrea, additional, and Nobili, Flavio, additional

Published
2020
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4. FDG-PET and CSF biomarker accuracy in prediction of conversion to different dementias in a large multicentre MCI cohort

Author

Parnetti, Lucilla, Eusebi, Paolo, Frisoni, Giovanni, Nobili, Flavio, Picco, Agnese, Scarpini, Elio, Caminiti, Silvia Paola, Ballarini, Tommaso, Sala, Arianna, Cerami, Chiara, Presotto, Luca, Santangelo, Roberto, Fallanca, Federico, Vanoli, Emilia Giovanna, Gianolli, Luigi, Iannaccone, Sandro, Magnani, Giuseppe, and Perani, Daniela

Published
2018
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5. The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study

Author

Bosco, Paolo, Redolfi, Alberto, Bocchetta, Martina, Ferrari, Clarissa, Mega, Anna, Galluzzi, Samantha, Austin, Mark, Chincarini, Andrea, Collins, D. Louis, Duchesne, Simon, Maréchal, Bénédicte, Roche, Alexis, Sensi, Francesco, Wolz, Robin, Alegret, Montserrat, Assal, Frederic, Balasa, Mircea, Bastin, Christine, Bougea, Anastasia, Emek-Savaş, Derya Durusu, Engelborghs, Sebastiaan, Grimmer, Timo, Grosu, Galina, Kramberger, Milica G., Lawlor, Brian, Mandic Stojmenovic, Gorana, Marinescu, Mihaela, Mecocci, Patrizia, Molinuevo, José Luis, Morais, Ricardo, Niemantsverdriet, Ellis, Nobili, Flavio, Ntovas, Konstantinos, O'Dwyer, Sarah, Paraskevas, George P., Pelini, Luca, Picco, Agnese, Salmon, Eric, Santana, Isabel, Sotolongo-Grau, Oscar, Spiru, Luiza, Stefanova, Elka, Popovic, Katarina Surlan, Tsolaki, Magda, Yener, Görsev G., Zekry, Dina, and Frisoni, Giovanni B.

Published
2017
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6. Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

Author

Frisoni, Giovanni B, Boccardi, Marina, Barkhof, Frederik, Blennow, Kaj, Cappa, Stefano, Chiotis, Konstantinos, Démonet, Jean-Francois, Garibotto, Valentina, Giannakopoulos, Panteleimon, Gietl, Anton, Hansson, Oskar, Herholz, Karl, Jack, Clifford R, Jr, Nobili, Flavio, Nordberg, Agneta, Snyder, Heather M, Ten Kate, Mara, Varrone, Andrea, Albanese, Emiliano, Becker, Stefanie, Bossuyt, Patrick, Carrillo, Maria C, Cerami, Chiara, Dubois, Bruno, Gallo, Valentina, Giacobini, Ezio, Gold, Gabriel, Hurst, Samia, Lönneborg, Anders, Lovblad, Karl-Olof, Mattsson, Niklas, Molinuevo, José-Luis, Monsch, Andreas U, Mosimann, Urs, Padovani, Alessandro, Picco, Agnese, Porteri, Corinna, Ratib, Osman, Saint-Aubert, Laure, Scerri, Charles, Scheltens, Philip, Schott, Jonathan M, Sonni, Ida, Teipel, Stefan, Vineis, Paolo, Visser, Pieter Jelle, Yasui, Yutaka, and Winblad, Bengt

Published
2017
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12. Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: A multicentric resting-state fMRI study

Author

Jovicich, Jorge, Minati, Ludovico, Marizzoni, Moira, Marchitelli, Rocco, Sala-Llonch, Roser, Bartrés-Faz, David, Arnold, Jennifer, Benninghoff, Jens, Fiedler, Ute, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio, Blin, Oliver, Bombois, Stephanie, Lopes, Renaud, Bordet, Régis, Sein, Julien, Ranjeva, Jean-Philippe, Didic, Mira, Gros-Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Bargalló, Núria, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Cavaliere, Carlo, Soricelli, Andrea, Parnetti, Lucilla, Tarducci, Roberto, Floridi, Piero, Tsolaki, Magda, Constantinidis, Manos, Drevelegas, Antonios, Rossini, Paolo Maria, Marra, Camillo, Schönknecht, Peter, Hensch, Tilman, Hoffmann, Karl-Titus, Kuijer, Joost P., Visser, Pieter Jelle, Barkhof, Frederik, and Frisoni, Giovanni B.

Published
2016
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16. Neuroimaging Findings in Mild Cognitive Impairment

Author

Nobili, Flavio, Arnaldi, Dario, Roccatagliata, Luca, Chincarini, Andrea, Accardo, Jennifer, Picco, Agnese, Ferrara, Michela, Buschiazzo, Ambra, Morbelli, Silvia, Dierckx, Rudi A.J.O., editor, Otte, Andreas, editor, de Vries, Erik F.J., editor, van Waarde, Aren, editor, and Leenders, Klaus L., editor

Published
2014
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17. Multisite longitudinal reliability of tract-based spatial statistics in diffusion tensor imaging of healthy elderly subjects

Author

Jovicich, Jorge, Marizzoni, Moira, Bosch, Beatriz, Bartrés-Faz, David, Arnold, Jennifer, Benninghoff, Jens, Wiltfang, Jens, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio, Blin, Oliver, Bombois, Stephanie, Lopes, Renaud, Bordet, Régis, Chanoine, Valérie, Ranjeva, Jean-Philippe, Didic, Mira, Gros-Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Bargalló, Núria, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Ragucci, Monica, Soricelli, Andrea, Salvadori, Nicola, Tarducci, Roberto, Floridi, Piero, Tsolaki, Magda, Constantinidis, Manos, Drevelegas, Antonios, Rossini, Paolo Maria, Marra, Camillo, Otto, Josephin, Reiss-Zimmermann, Martin, Hoffmann, Karl-Titus, Galluzzi, Samantha, and Frisoni, Giovanni B.

Published
2014
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24. Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques

Author

Marchitelli, Rocco, Minati, Ludovico, Marizzoni, Moira, Bosch, Beatriz, Bartrés-Faz, David, Müller, Bernhard W., Wiltfang, Jens, Fiedler, Ute, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio, Blin, Oliver, Bombois, Stephanie, Lopes, Renaud, Bordet, Régis, Sein, Julien, Ranjeva, Jean-Philippe, Didic, Mira, Gros-Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Bargalló, Núria, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Cavaliere, Carlo, Soricelli, Andrea, Parnetti, Lucilla, Tarducci, Roberto, Floridi, Piero, Tsolaki, Magda, Constantinidis, Manos, Drevelegas, Antonios, Rossini, Paolo Maria, Marra, Camillo, Schönknecht, Peter, Hensch, Tilman, Hoffmann, Karl-Titus, Kuijer, Joost P., Visser, Pieter Jelle, Barkhof, Frederik, Frisoni, Giovanni B., and Jovicich, Jorge

Published
2016
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25. Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly

Author

Marizzoni, Moira, Antelmi, Luigi, Bosch, Beatriz, Bartrés-Faz, David, Müller, Bernhard W., Wiltfang, Jens, Fiedler, Ute, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio, Blin, Olivier, Bombois, Stephanie, Lopes, Renaud, Sein, Julien, Ranjeva, Jean-Philippe, Didic, Mira, Gros-Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Bargalló, Núria, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Cavaliere, Carlo, Soricelli, Andrea, Salvadori, Nicola, Parnetti, Lucilla, Tarducci, Roberto, Floridi, Piero, Tsolaki, Magda, Constantinidis, Manos, Drevelegas, Antonios, Rossini, Paolo Maria, Marra, Camillo, Hoffmann, Karl-Titus, Hensch, Tilman, Schönknecht, Peter, Kuijer, Joost P., Visser, Pieter Jelle, Barkhof, Frederik, Bordet, Régis, Frisoni, Giovanni B., and Jovicich, Jorge

Published
2015
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27. Biomarkers validation in Alzheimer’s Disease and related pathologies

Author

PICCO, AGNESE

Subjects
Alzheimer's Disease Biomarker Dementia Mild Cognitive Impairment FDG PET Depressive Pseudodementia, Settore MED/26 - Neurologia
Abstract

The aim of this research project was to investigate biomarkers of Alzheimer?s disease (AD) and related pathologies. The future of these biomarkers relies in their proper validation in all settings (analytical and clinical). In the first two papers, I cooperated with a task force of expert in AD and oncology field, who adapted a framework for biomarkers development used in oncology to AD. We assessed existing evidence based on this framework for amyloid-PET; CSF Abeta42, tau/phospho-tau; FDG-PET; hippocampal atrophy, 123I-Ioflupane, 123I-MIBG, and neuropsychology. Then, I focused my PhD projects on one of the most reliable biomarkers of AD: brain metabolism by means of FDG PET and its clinical and validity among the phases of the roadmap framework. As FDG-PET rely its utility in AD not only as a diagnostic but also as a progression biomarker, we tried to use this powerful tool to clarify functional pattern able to predict future conversion to AD. One of the limitations of the latter studies was to have excluded from the sample patients with other disease than AD. This was done essentially for research purpose, but hampered the possibility to explore different metabolic patterns underpinning a mild cognitive impairment not due to AD. So, we explore the utility of FDGPET in the context of a relatively frequent syndrome who could mimic early symptoms of AD, DPD. Our results were: by means of strategic five-phase roadmap, sufficient evidence of analytical validity (phase 1) is available for all biomarkers, but their clinical validity (phases 2 and 3) and clinical utility (phases 4 and 5) are incomplete. In order to assess the accuracy of FDG PET in discriminating MCI patients who converted to AD from those who did not, we found that MCI patients not converting to AD within a minimum follow-up time of 5 years and MCI patients converting within 5 years, baseline FDG PET and volume based analysis identified those who converted with an accuracy of 89%. With the aim to identify the cortical regions where hypometabolism can predict the speed of conversion to dementia in MCIAD we found a diagnostic-pattern. This is a further, independent source of heterogeneity in MCI-AD and affects a primary-endpoint on interventional clinical trials (time of conversion to dementia). Finally, with the aim to explore the role of FDG PET in the diagnosis of DPD, we compared brain FDG-PET among DPD patients, patients with early AD and normal subjects. We found that DPD patients had a specific relative hypometabolism both on caudate nuclei and right anterior cingulate (BA 25). This study confirms the role of FDG PET in the diagnosis of DPD and pave the way of a better understanding of its underpinning biological alterations. In conclusion, during my PhD I explored the necessity to define the validity of biomarkers of AD and related pathologies in patients with MCI: from operative and analytic point of view, to clinical settings. Then I focused on the real clinical implication of one of the most useful and reliable biomarkers, FDG PET. Our findings support its role of a robust progression biomarker even in a naturalistic population, and underline its importance in the early diagnosis of AD.

Published
2020

28. Accuracy and reproducibility of automated white matter hyperintensities segmentation with lesion segmentation tool: A European multi-site 3T study

Author

Ribaldi, Federica, primary, Altomare, Daniele, additional, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Picco, Agnese, additional, Pizzini, Francesca Benedetta, additional, Soricelli, Andrea, additional, Mega, Anna, additional, Ferretti, Antonio, additional, Drevelegas, Antonios, additional, Bosch, Beatriz, additional, Müller, Bernhard W., additional, Marra, Camillo, additional, Cavaliere, Carlo, additional, Bartrés-Faz, David, additional, Nobili, Flavio, additional, Alessandrini, Franco, additional, Barkhof, Frederik, additional, Gros-Dagnac, Helene, additional, Ranjeva, Jean-Philippe, additional, Wiltfang, Jens, additional, Kuijer, Joost, additional, Sein, Julien, additional, Hoffmann, Karl-Titus, additional, Roccatagliata, Luca, additional, Parnetti, Lucilla, additional, Tsolaki, Magda, additional, Constantinidis, Manos, additional, Aiello, Marco, additional, Salvatore, Marco, additional, Montalti, Martina, additional, Caulo, Massimo, additional, Didic, Mira, additional, Bargallo, Núria, additional, Blin, Olivier, additional, Rossini, Paolo M, additional, Schonknecht, Peter, additional, Floridi, Piero, additional, Payoux, Pierre, additional, Visser, Pieter Jelle, additional, Bordet, Régis, additional, Lopes, Renaud, additional, Tarducci, Roberto, additional, Bombois, Stephanie, additional, Hensch, Tilman, additional, Fiedler, Ute, additional, Richardson, Jill C., additional, Frisoni, Giovanni B., additional, and Marizzoni, Moira, additional

Published
2021
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29. Una sfida per la scienza: Genesi ed evoluzione del pensiero di Cesare Lombroso sullo spiritismo.

Author

Picco, Agnese

Subjects
CRIMINAL anthropology, CRIMINAL psychology, SPIRITUALISM, OCCULTISM
Abstract

Spiritism is an historical phenomenon with specific features that can be defined and contextualised chronologically. Starting from 1872, the academic world became increasingly fascinated with spiritism. In Italy, Cesare Lombroso - the father of criminal anthropology - was one of its most dedicated inquirers. This research investigates the relationship between Lombroso and spiritism, and its evolution over time, starting from the systematic study of his correspondence and his journal Archivio di Psichiatria. By comparing such works with Lombroso’s public production, it is possible to reconstruct the progression of his participation in the spiritist movement. After an initial period of undecidedness, where he considered spiritist phenomena as a product of the medium’s mind, Lombroso gradually embraced them, until he accepted the existence of spirits as a fact. [ABSTRACT FROM AUTHOR]

Published
2022
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30. White Matter Hyperintensities Are No Major Confounder for Alzheimer’s Disease Cerebrospinal Fluid Biomarkers

Author

van Waalwijk van Doorn, Linda J.C., primary, Ghafoorian, Mohsen, additional, van Leijsen, Esther M.C., additional, Claassen, Jurgen A.H.R., additional, Arighi, Andrea, additional, Bozzali, Marco, additional, Cannas, Jorge, additional, Cavedo, Enrica, additional, Eusebi, Paolo, additional, Farotti, Lucia, additional, Fenoglio, Chiara, additional, Fortea, Juan, additional, Frisoni, Giovanni B., additional, Galimberti, Daniela, additional, Greco, Viviana, additional, Herukka, Sanna-Kaisa, additional, Liu, Yawu, additional, Lleó, Alberto, additional, de Mendonça, Alexandre, additional, Nobili, Flavio M., additional, Parnetti, Lucilla, additional, Picco, Agnese, additional, Pikkarainen, Maria, additional, Salvadori, Nicola, additional, Scarpini, Elio, additional, Soininen, Hilkka, additional, Tarducci, Roberto, additional, Urbani, Andrea, additional, Vilaplana, Eduard, additional, Meulenbroek, Olga, additional, Platel, Bram, additional, Verbeek, Marcel M., additional, and Kuiperij, H. Bea, additional

Published
2021
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31. Amygdalar nuclei and hippocampal subfields on MRI: Test‐retest reliability of automated segmentation in old and young healthy volunteers

Author

Quattrini, Giulia, primary, Pievani, Michela, additional, Jovicich, Jorge, additional, Aiello, Marco, additional, Bargalló, Nuria, additional, Barkhof, Frederik, additional, Bartrés‐Faz, David, additional, Beltramello, Alberto, additional, Pizzini, Francesca B, additional, Blin, Olivier, additional, Bordet, Régis, additional, Caulo, Massimo, additional, Constantinides, Manos, additional, Didic, Mira, additional, Drevelegas, Antonios, additional, Ferretti, Antonio, additional, Fiedler, Ute, additional, Floridi, Piero, additional, Gros‐Dagnac, Helene, additional, Hensch, Tilman, additional, Hoffmann, Karl‐Titus, additional, Kuijer, Joost, additional, Lopes, Renaud, additional, Marra, Camillo, additional, Müller, Bernhard W., additional, Nobili, Flavio, additional, Parnetti, Lucilla, additional, Payoux, Pierre, additional, Picco, Agnese, additional, Ranjeva, Jean‐Philippe, additional, Roccatagliata, Luca, additional, Rossini, Paolo Maria, additional, Salvatore, Marco, additional, Schonknecht, Peter, additional, Schott, Björn H, additional, Sein, Julien, additional, Soricelli, Andrea, additional, Tarducci, Roberto, additional, Tsolaki, Magda, additional, Visser, Pieter Jelle, additional, Wiltfang, Jens, additional, Richardson, Jill, additional, Frisoni, Giovanni B, additional, Marizzoni, Moira, additional, and Consortium, PharmaCog, additional

Published
2020
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32. Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors

Author

Quattrini, Giulia, primary, Pievani, Michela, additional, Jovicich, Jorge, additional, Aiello, Marco, additional, Bargalló, Núria, additional, Barkhof, Frederik, additional, Bartres-Faz, David, additional, Beltramello, Alberto, additional, Pizzini, Francesca B., additional, Blin, Olivier, additional, Bordet, Regis, additional, Caulo, Massimo, additional, Constantinides, Manos, additional, Didic, Mira, additional, Drevelegas, Antonios, additional, Ferretti, Antonio, additional, Fiedler, Ute, additional, Floridi, Piero, additional, Gros-Dagnac, Hélène, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost P., additional, Lopes, Renaud, additional, Marra, Camillo, additional, Müller, Bernhard W., additional, Nobili, Flavio, additional, Parnetti, Lucilla, additional, Payoux, Pierre, additional, Picco, Agnese, additional, Ranjeva, Jean-Philippe, additional, Roccatagliata, Luca, additional, Rossini, Paolo M., additional, Salvatore, Marco, additional, Schonknecht, Peter, additional, Schott, Björn H., additional, Sein, Julien, additional, Soricelli, Andrea, additional, Tarducci, Roberto, additional, Tsolaki, Magda, additional, Visser, Pieter J., additional, Wiltfang, Jens, additional, Richardson, Jill C., additional, Frisoni, Giovanni B., additional, and Marizzoni, Moira, additional

Published
2020
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34. Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer’s disease

Author

Ramusino, Matteo Cotta, primary, Garibotto, Valentina, additional, Bacchin, Ruggero, additional, Altomare, Daniele, additional, Dodich, Alessandra, additional, Assal, Frederic, additional, Mendes, Aline, additional, Costa, Alfredo, additional, Tinazzi, Michele, additional, Morbelli, Silvia D., additional, Bauckneht, Matteo, additional, Picco, Agnese, additional, Dottorini, Massimo E., additional, Tranfaglia, Cristina, additional, Farotti, Lucia, additional, Salvadori, Nicola, additional, Moretti, Davide, additional, Savelli, Giordano, additional, Tarallo, Anna, additional, Nobili, Flavio, additional, Parapini, Maura, additional, Cavaliere, Carlo, additional, Salvatore, Elena, additional, Salvatore, Marco, additional, Boccardi, Marina, additional, and Frisoni, Giovanni B, additional

Published
2019
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35. IC‐P‐006: THE INCREMENTAL VALUE OF AMYLOID PET VERSUS CSF BIOMARKERS FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE (INDIA–FBB STUDY)

Author

Ramusino, Matteo Cotta, primary, Altomare, Daniele, additional, Assal, Frederic, additional, Mendes, Aline, additional, Costa, Alfredo, additional, Morbelli, Silvia, additional, Bauckneht, Matteo, additional, Picco, Agnese, additional, Dottorini, Massimo Eugenio, additional, Farotti, Lucia, additional, Moretti, Davide, additional, Savelli, Giordano, additional, Tarallo, Anna, additional, Parnetti, Lucilla, additional, Nobili, Flavio Mariano, additional, Parapini, Maura, additional, Salvatore, Elena, additional, Salvatore, Marco, additional, Boccardi, Marina, additional, and Frisoni, Giovanni B., additional

Published
2018
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36. P1‐393: THE INCREMENTAL VALUE OF AMYLOID PET VERSUS CSF BIOMARKERS FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE (INDIA–FBB STUDY)

Author

Ramusino, Matteo Cotta, primary, Altomare, Daniele, additional, Assal, Frederic, additional, Mendes, Aline, additional, Costa, Alfredo, additional, Morbelli, Silvia, additional, Bauckneht, Matteo, additional, Picco, Agnese, additional, Dottorini, Massimo Eugenio, additional, Farotti, Lucia, additional, Moretti, Davide, additional, Savelli, Giordano, additional, Tarallo, Anna, additional, Parnetti, Lucilla, additional, Nobili, Flavio Mariano, additional, Parapini, Maura, additional, Salvatore, Elena, additional, Salvatore, Marco, additional, Boccardi, Marina, additional, and Frisoni, Giovanni B., additional

Published
2018
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37. IC‐P‐126: VOLUMETRIC ACCURACY OF A FULLY AUTOMATIC TOOL FOR WHITE MATTER HYPERINTENSITIES (WMHS) SEGMENTATION

Author

Ribaldi, Federica, primary, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Montalti, Martina, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Régis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargallo, Núria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, Frisoni, Giovanni B., additional, and Marizzoni, Moira, additional

Published
2018
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38. The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: An EADC study

Author

Bosco, Paolo, Redolfi, Alberto, Bocchetta, Martina, Engelborghs, Sebastiaan, Ferrari, Clarissa, Mega, Anna, Galluzzi, Samantha, Austin, Mark, Chincarini, Andrea, Collins, D. Louis, Duchesne, Simon, Marechal, Benedicte, Roche, Alexis, Sensi, Francesco, Wolz, Robin, Alegret, Montserrat, Assal, Frederic, Balasa, Mircea, Bastin, Christine, Bougea, Anastasia, Emek-Savas, Derya Durusu, Grimmer, Timo, Grosu, Galina, Kramberger, Milica G., Lawlor, Brian, Stojmenovic, Gorana Mandic, Marinescu, Mihaela, Mecocci, Patrizia, Molinuevo, Jose Luis, Morais, Ricardo, Niemantsverdriet, Ellis, Nobili, Flavio, Ntovas, Konstantinos, O'Dwyer, Sarah, Paraskevas, George P., Pelini, Luca, Picco, Agnese, Salmon, Eric, Santana, Isabel, Sotolongo-Grau, Oscar, Spiru, Luiza, Stefanova, Elka, Popovic, Katarina Surlan, Tsolaki, Magda, Yener, Gorsev G., Zekry, Dina, and Frisoni, Giovanni B.

Subjects
Epidemiology, Health Policy, Alzheimer's disease, Biomarkers, Diagnostic confidence of AD, Hippocampal volume, Medial temporal lobe atrophy, Developmental Neuroscience, Geriatrics and Gerontology, Neurology (clinical), Cellular and Molecular Neuroscience, Psychiatry and Mental Health, Human medicine
Abstract

Introduction: Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. Methods: Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini-Mental State Examination >= 20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed. Results: An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of 28.0% (95% credible interval: [211.5, 25.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18 F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (28.5, CrI: [211.5, 25.6]; 214.1, CrI: [219.3, 28.8]; 210.6, CrI: [214.6, 26.1], respectively). Discussion: There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Published
2017

39. FDG-PET and CSF biomarker accuracy in prediction of conversion to different dementias in a large multicentre MCI cohort

Author

Caminiti, Silvia Paola, primary, Ballarini, Tommaso, additional, Sala, Arianna, additional, Cerami, Chiara, additional, Presotto, Luca, additional, Santangelo, Roberto, additional, Fallanca, Federico, additional, Vanoli, Emilia Giovanna, additional, Gianolli, Luigi, additional, Iannaccone, Sandro, additional, Magnani, Giuseppe, additional, Perani, Daniela, additional, Parnetti, Lucilla, additional, Eusebi, Paolo, additional, Frisoni, Giovanni, additional, Nobili, Flavio, additional, Picco, Agnese, additional, and Scarpini, Elio, additional

Published
2018
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40. [IC-P-167]: ACROSS-SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI-SITE 3T STUDY

Author

Ribaldi, Federica, primary, Marizzoni, Moira, additional, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Regis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargalló, Nuria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo Maria, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, and Frisoni, Giovanni B., additional

Published
2017
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41. ACROSS-SESSION REPRODUCIBILITY OF AUTOMATIC WHITE MATTER HYPERINTENSITIES SEGMENTATION: A EUROPEAN MULTI-SITE 3T STUDY

Author

Ribaldi, Federica, primary, Marizzoni, Moira, additional, Jovicich, Jorge, additional, Ferrari, Clarissa, additional, Bosch, Beatriz, additional, Bartrés-Faz, David, additional, Müller, Bernhard W., additional, Wiltfang, Jens, additional, Fiedler, Ute, additional, Roccatagliata, Luca, additional, Picco, Agnese, additional, Nobili, Flavio, additional, Blin, Olivier, additional, Bombois, Stephanie, additional, Lopes, Renaud, additional, Bordet, Regis, additional, Sein, Julien, additional, Ranjeva, Jean-Philippe, additional, Didic, Mira, additional, Gros-Dagnac, Helene, additional, Payoux, Pierre, additional, Zoccatelli, Giada, additional, Alessandrini, Franco, additional, Beltramello, Alberto, additional, Bargallo, Núria, additional, Ferretti, Antonio, additional, Caulo, Massimo, additional, Aiello, Marco, additional, Cavaliere, Carlo, additional, Soricelli, Andrea, additional, Parnetti, Lucilla, additional, Tarducci, Robertto, additional, Floridi, Piero, additional, Tsolaki, Magda, additional, Constantinides, Manos, additional, Drevelegas, Antonios, additional, Rossini, Paolo Maria, additional, Marra, Camillo, additional, Schonknecht, Peter, additional, Hensch, Tilman, additional, Hoffmann, Karl-Titus, additional, Kuijer, Joost, additional, Visser, Pieter Jelle, additional, Barkhof, Frederik, additional, and Frisoni, Giovanni B., additional

Published
2017
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42. Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework

Author

Chiotis, Konstantinos, primary, Saint-Aubert, Laure, additional, Boccardi, Marina, additional, Gietl, Anton, additional, Picco, Agnese, additional, Varrone, Andrea, additional, Garibotto, Valentina, additional, Herholz, Karl, additional, Nobili, Flavio, additional, Nordberg, Agneta, additional, Frisoni, Giovanni B., additional, Winblad, Bengt, additional, and Jack, Clifford R, additional

Published
2017
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43. IC‐P‐006: THE INCREMENTAL VALUE OF AMYLOID PET VERSUS CSF BIOMARKERS FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE (INDIA–FBB STUDY).

Author

Ramusino, Matteo Cotta, Altomare, Daniele, Assal, Frederic, Mendes, Aline, Costa, Alfredo, Morbelli, Silvia, Bauckneht, Matteo, Picco, Agnese, Dottorini, Massimo Eugenio, Farotti, Lucia, Moretti, Davide, Savelli, Giordano, Tarallo, Anna, Parnetti, Lucilla, Nobili, Flavio Mariano, Parapini, Maura, Salvatore, Elena, Salvatore, Marco, Boccardi, Marina, and Frisoni, Giovanni B.

Published
2023
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44. Free water elimination improves test–retest reproducibility of diffusion tensor imaging indices in the brain: A longitudinal multisite study of healthy elderly subjects

Author

Albi, Angela, Pasternak, Ofer, Minati, Ludovico, Marizzoni, Moira, Bartrés Faz, David, Bargalló, Núria, Bosch, Beatriz, Rossini, Paolo Maria, Marra, Camillo, Müller, Bernhard, Fiedler, Ute, Wiltfang, Jen, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio Mariano, Blin, Oliver, Sein, Julien, Ranjeva, Jean Philippe, Didic, Mira, Bombois, Stephanie, Lopes, Renaud, Bordet, Régi, Gros Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Cavaliere, Carlo, Soricelli, Andrea, Parnetti, Lucilla, Tarducci, Roberto, Floridi, Piero, Tsolaki, Magda, Constantinidis, Mano, Drevelegas, Antonio, Frisoni, Giovanni, Jovicich, Jorge, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Marra, Camillo (ORCID:0000-0003-3994-4044), Albi, Angela, Pasternak, Ofer, Minati, Ludovico, Marizzoni, Moira, Bartrés Faz, David, Bargalló, Núria, Bosch, Beatriz, Rossini, Paolo Maria, Marra, Camillo, Müller, Bernhard, Fiedler, Ute, Wiltfang, Jen, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio Mariano, Blin, Oliver, Sein, Julien, Ranjeva, Jean Philippe, Didic, Mira, Bombois, Stephanie, Lopes, Renaud, Bordet, Régi, Gros Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Cavaliere, Carlo, Soricelli, Andrea, Parnetti, Lucilla, Tarducci, Roberto, Floridi, Piero, Tsolaki, Magda, Constantinidis, Mano, Drevelegas, Antonio, Frisoni, Giovanni, Jovicich, Jorge, Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), and Marra, Camillo (ORCID:0000-0003-3994-4044)

Abstract

Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not clear if these two models differ in their test–retest reproducibility. This study compares a bi-tensor model for FWE with DTI by extending a previous longitudinal-reproducibility 3T multisite study (10 sites, 7 different scanner models) of 50 healthy elderly participants (55–80 years old) scanned in two sessions at least 1 week apart. We computed the reproducibility of commonly used DTI metrics (FA: fractional anisotropy, MD: mean diffusivity, RD: radial diffusivity, and AXD: axial diffusivity), derived either using a DTI model or a FWE model. The DTI metrics were evaluated over 48 white-matter regions of the JHU-ICBM-DTI-81 white-matter labels atlas, and reproducibility errors were assessed. We found that relative to the DTI model, FWE significantly reduced reproducibility errors in most areas tested. In particular, for the FA and MD metrics, there was an average reduction of approximately 1% in the reproducibility error. The reproducibility scores did not significantly differ across sites. This study shows that FWE improves sensitivity and is thus promising for clinical applications, with the potential to identify more subtle changes. The increased reproducibility allows for smaller sample size or shorter trials in studies evaluating biomarkers of disease progression or treatment effects. Hum Brain Mapp 38:12–26, 2017. © 2016 Wiley Periodicals, Inc.

Published
2017

45. Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer’s Disease Patients and Controls after Correction for Ventricular Volumes

Author

van Waalwijk van Doorn, Linda J.C., primary, Gispert, Juan D., additional, Kuiperij, H. Bea, additional, Claassen, Jurgen A.H.R., additional, Arighi, Andrea, additional, Baldeiras, Inês, additional, Blennow, Kaj, additional, Bozzali, Marco, additional, Castelo-Branco, Miguel, additional, Cavedo, Enrica, additional, Emek-Savaş, Derya D., additional, Eren, Erden, additional, Eusebi, Paolo, additional, Farotti, Lucia, additional, Fenoglio, Chiara, additional, Ormaechea, Juan Fortea, additional, Freund-Levi, Yvonne, additional, Frisoni, Giovanni B., additional, Galimberti, Daniela, additional, Genc, Sermin, additional, Greco, Viviana, additional, Hampel, Harald, additional, Herukka, Sanna-Kaisa, additional, Liu, Yawu, additional, Lladó, Albert, additional, Lleó, Alberto, additional, Nobili, Flavio M., additional, Oguz, Kader K., additional, Parnetti, Lucilla, additional, Pereira, João, additional, Picco, Agnese, additional, Pikkarainen, Maria, additional, de Oliveira, Catarina Resende, additional, Saka, Esen, additional, Salvadori, Nicola, additional, Sanchez-Valle, Raquel, additional, Santana, Isabel, additional, Scarpini, Elio, additional, Scheltens, Philip, additional, Soininen, Hilkka, additional, Tarducci, Roberto, additional, Teunissen, Charlotte, additional, Tsolaki, Magda, additional, Urbani, Andrea, additional, Vilaplana, Eduard, additional, Visser, Pieter Jelle, additional, Wallin, Asa K., additional, Yener, Görsev, additional, Molinuevo, José L., additional, Meulenbroek, Olga, additional, and Verbeek, Marcel M., additional

Published
2017
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46. P3-209: Impact of Biomarkers On Diagnostic Confidence in Clinical Assessment of Patients with Suspected Alzheimer's Disease and High Diagnostic Uncertainty: An EADC Study

Author

Bosco, Paolo, primary, Redolfi, Alberto, additional, Bocchetta, Martina, additional, Ferrari, Clarissa, additional, Mega, Anna, additional, Galluzzi, Samantha, additional, Assal, Frederic, additional, Balasa, Mircea, additional, Bastin, Christine, additional, Bougea, Anastasia, additional, Emek-Savas, Derya Durusu, additional, Engelborghs, Sebastiaan, additional, Giannakopoulos, Panteleimon, additional, Gold, Gabriel, additional, Grimmer, Timo, additional, Grosu, Galina, additional, Kramberger, Milica G., additional, Lawlor, Brian, additional, Stojmenovic, Gorana Mandic, additional, Marinescu, Mihaela, additional, Mecocci, Patrizia, additional, Molinuevo, Jose Luis, additional, Morais, Ricardo, additional, Niemantsverdriet, Ellis, additional, Nobili, Flavio, additional, Ntovas, Konstantinos, additional, O'Dwyer, Sarah, additional, Paraskevas, George, additional, Pelini, Luca, additional, Picco, Agnese, additional, Salmon, Eric, additional, Santana, Isabel, additional, Sotolongo-Grau, Oscar, additional, Spiru, Luiza, additional, Stefanova, Elka, additional, Popovic, Katarina Surlan, additional, Tsolaki, Magda, additional, Yener, Görsev, additional, Zekry, Dina, additional, and Frisoni, Giovanni B., additional

Published
2016
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