1. Insulin-like growth factor-1 predicts cognitive functions at 2-year follow-up in early, drug-naïve Parkinson's disease
- Author
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Marianna Amboni, A. Colao, Paolo Barone, Gabriella Santangelo, Katia Longo, A. De Rosa, Claudia Pivonello, Rosario Pivonello, Marcello Moccia, Carmine Vitale, Roberto Erro, Lucia Santoro, G. De Michele, Marina Picillo, Maria Teresa Pellecchia, Pellecchia, Mt, Santangelo, G, Piccillo, M, Pivonello, Rosario, Longo, K, Pivonello, C, Vitale, C, Amboni, M, DE ROSA, Anna, Moccia, M, Erro, R, DE MICHELE, Giuseppe, Santoro, L, Colao, A, Barone, P., Pellecchia, M. T., Santangelo, G., Picillo, M., Pivonello, R., Longo, K., Pivonello, C., Vitale, C., Amboni, M., De Rosa, A., Moccia, M., Erro, R., De Michele, G., Santoro, L., and Colao, A.
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,cognitive functions ,early Parkinson's disease ,insulin-like growth factor-1 ,Acoustic Stimulation ,Analysis of Variance ,Cognition Disorders ,Female ,Humans ,Insulin-Like Growth Factor I ,Longitudinal Studies ,Neuropsychological Tests ,Parkinson Disease ,Regression Analysis ,Verbal Learning ,Longitudinal Studie ,Audiology ,Verbal learning ,behavioral disciplines and activities ,Regression Analysi ,Developmental psychology ,Cognition Disorder ,medicine ,business.industry ,Neuropsychology ,Early Parkinson's disease ,Cognition ,medicine.disease ,Drug-naïve ,Insulin-like growth factor-1 ,Neurology ,Neuropsychological Test ,Cognitive function ,Neurology (clinical) ,Analysis of variance ,Verbal memory ,business ,Human ,Stroop effect ,medicine.drug - Abstract
Background and purpose: Cognitive impairment is common in Parkinson's disease (PD), even in the early stages. We aimed to assess the relationship between insulin-like growth factor-1 (IGF-1) and cognitive functions in early, drug-naïve patients with PD. Methods: Serum IGF-1 was measured in 65 early, drug-naïve patients with PD that underwent a complete neuropsychological battery at baseline and after 2years. Linear regression analysis was used to evaluate the relationships between neuropsychological scores and IGF-1. Repeated-measures anova was applied to assess changes in neuropsychological variables over time. Results: At baseline, IGF-1 levels were related to phonological fluency. At follow-up, IGF-1 levels were associated with the Rey auditory verbal learning test (RAVLT) - immediate and delayed recall, Frontal Assessment Battery, verbal span and Benton judgement of the line orientation test. Patients with low IGF-1 levels at baseline showed a significantly faster decline of performances than patients with high IGF-1 levels on immediate and delayed recall of the RAVLT and interference task of the Stroop test. Conclusions: Low serum IGF-1 levels are related to poor performance on executive tasks in early, drug-naïve patients with PD, and may predict poor performance on attention/executive and verbal memory tasks after a 2-year follow-up. © 2013 The Author(s) European Journal of Neurology © 2013 EFNS.
- Published
- 2013