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5 results on '"Picchi, R"'

1. Pulmonary function in Williams-Beuren syndrome: Spirometric data of 22 Italian patients

Author

Pangallo, E, Cianci, P, Favuzza, F, Milani, D, Vimercati, C, Moretti, A, Picchi, R, De Paoli, A, Agosti, M, Selicorni, A, Pangallo, Elisabetta, Cianci, Paola, Favuzza, Filippo, Milani, Donatella, Vimercati, Chiara, Moretti, Alex, Picchi, Raffaella, De Paoli, Anita, Agosti, Massimo, Selicorni, Angelo, Pangallo, E, Cianci, P, Favuzza, F, Milani, D, Vimercati, C, Moretti, A, Picchi, R, De Paoli, A, Agosti, M, Selicorni, A, Pangallo, Elisabetta, Cianci, Paola, Favuzza, Filippo, Milani, Donatella, Vimercati, Chiara, Moretti, Alex, Picchi, Raffaella, De Paoli, Anita, Agosti, Massimo, and Selicorni, Angelo

Abstract

Williams–Beuren syndrome (WBS) is caused by an haploinsufficiency of the 7q11.2 region which involves the elastin gene (ELN). A deficiency of elastin is a known pathophysiological mechanism of emphysema/chronic obstructive pulmonary disease (COPD). A previous study hypothesized a higher risk of COPD in WBS patients. Herein, this phenomenon was further investigated looking for a possible correlation between COPD and WBS. Dynamic lung volumes (forced vital capacity [FVC], FEV1, FEV1/FVC) were measured in 22 patients (age range 18.9 ± 7.4 years) affected with WBS, genetically confirmed, correlating these parameters to respiratory risk factors. Dyspnea, cough and wheezing were detected in 6/22 (27%) patients. Obstructive and restrictive patterns were identified in 6/22 (27%) and 2/22 (9%) cases, respectively with no evidence of irreversible obstruction. CVF, FEV1 and FEV1/CVF mean values were all normal, with values of 91.3% (n.v. > 80%), 84.2% (n.v. > 80%) and 0.82 (n.v. > 0.7), respectively. The severity of the comorbidities did not show a cause-effect relation with the respiratory patterns, nevertheless patients treated with anti-hypertensive drugs had poorer pulmonary function. Our findings are in accordance with previous observations, showing that emphysema/COPD is not a typical finding in young patients with WBS. However, a respiratory function assessment should be included in the follow-up of WBS patients, especially in adolescents/young adults under treatment with anti-hypertensive drugs.

Published
2021

2. A recurrent ileitis

Author

Parma, B., primary, Ortisi, M.T., additional, Picchi, R., additional, Chierici, V., additional, and Abbagnato, L., additional

Published
2015
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4. Turing's unpublished algorithm for normal numbers

Author

Becher, V., Figueira, S., and Picchi, R.

Subjects
Computable absolutely normal numbers, Turing's unpublished manuscript, Normal numbers, Computable construction, Number theory, Lebesgue measure, Set theory, Turing machines, Error correction, Theorem proving, Manuscripts, Algorithms, Algorithm for normal numbers
Abstract

In an unpublished manuscript, Alan Turing gave a computable construction to show that absolutely normal real numbers between 0 and 1 have Lebesgue measure 1; furthermore, he gave an algorithm for computing instances in this set. We complete his manuscript by giving full proofs and correcting minor errors. While doing this, we recreate Turing's ideas as accurately as possible. One of his original lemmas remained unproved, but we have replaced it with a weaker lemma that still allows us to maintain Turing's proof idea and obtain his result. © 2007 Elsevier Ltd. All rights reserved. Fil:Becher, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Figueira, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.

Published
2007

5. Pulmonary function in Williams-Beuren syndrome: Spirometric data of 22 Italian patients

Author

Filippo Favuzza, Chiara Vimercati, Paola Cianci, Anita De Paoli, Raffaella Picchi, Alex Moretti, Donatella Milani, Angelo Selicorni, Elisabetta Pangallo, Massimo Agosti, Pangallo, E, Cianci, P, Favuzza, F, Milani, D, Vimercati, C, Moretti, A, Picchi, R, De Paoli, A, Agosti, M, and Selicorni, A

Subjects
Adult, Male, Williams Syndrome, Vital capacity, medicine.medical_specialty, Williams–Beuren syndrome, Adolescent, Vital Capacity, pulmonary function tests, chronic obstructive pulmonary disease, Pulmonary function testing, FEV1/FVC ratio, Pulmonary Disease, Chronic Obstructive, Young Adult, pulmonary function test, Risk Factors, Internal medicine, Genetics, medicine, Humans, Respiratory function, Lung volumes, spirometry examination, Respiratory system, Young adult, Child, Lung, Genetics (clinical), COPD, business.industry, Middle Aged, medicine.disease, elastin, emphysema, respiratory tract diseases, Elastin, Respiratory Function Tests, Italy, Pulmonary Emphysema, Spirometry, Cardiology, Female, business
Abstract

Williams–Beuren syndrome (WBS) is caused by an haploinsufficiency of the 7q11.2 region which involves the elastin gene (ELN). A deficiency of elastin is a known pathophysiological mechanism of emphysema/chronic obstructive pulmonary disease (COPD). A previous study hypothesized a higher risk of COPD in WBS patients. Herein, this phenomenon was further investigated looking for a possible correlation between COPD and WBS. Dynamic lung volumes (forced vital capacity [FVC], FEV1, FEV1/FVC) were measured in 22 patients (age range 18.9 ± 7.4 years) affected with WBS, genetically confirmed, correlating these parameters to respiratory risk factors. Dyspnea, cough and wheezing were detected in 6/22 (27%) patients. Obstructive and restrictive patterns were identified in 6/22 (27%) and 2/22 (9%) cases, respectively with no evidence of irreversible obstruction. CVF, FEV1 and FEV1/CVF mean values were all normal, with values of 91.3% (n.v. > 80%), 84.2% (n.v. > 80%) and 0.82 (n.v. > 0.7), respectively. The severity of the comorbidities did not show a cause-effect relation with the respiratory patterns, nevertheless patients treated with anti-hypertensive drugs had poorer pulmonary function. Our findings are in accordance with previous observations, showing that emphysema/COPD is not a typical finding in young patients with WBS. However, a respiratory function assessment should be included in the follow-up of WBS patients, especially in adolescents/young adults under treatment with anti-hypertensive drugs.

Published
2020

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