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2. The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium

Author

Loef, Bette, Boer, Jolanda M. A., Beekman, Marian, Campman, Sophie L., Hoogendijk, Emiel O., Huider, Floris, Pagen, Demi M. E., Splinter, Marije J., van der Velde, Jeroen H. P. M., Boomsma, Dorret I., Dagnelie, Pieter C., van Dongen, Jenny, de Geus, Eco J. C., Huisman, Martijn, Ikram, M. Arfan, Koster, Annemarie, Licher, Silvan, Mierau, Jochen O., de Mutsert, Renée, Picavet, H. Susan J., Rosendaal, Frits R., Schram, Miranda T., Slagboom, P. Eline, van der Spoel, Evie, Stronks, Karien, Verschuren, W. M. Monique, and van den Berg, Saskia W.

Published
2024
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4. Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts

Author

DiCorpo, Daniel, LeClair, Jessica, Cole, Joanne B, Sarnowski, Chloé, Ahmadizar, Fariba, Bielak, Lawrence F, Blokstra, Anneke, Bottinger, Erwin P, Chaker, Layal, Chen, Yii-Der I, Chen, Ye, de Vries, Paul S, Faquih, Tariq, Ghanbari, Mohsen, Gudmundsdottir, Valborg, Guo, Xiuqing, Hasbani, Natalie R, Ibi, Dorina, Ikram, M Arfan, Kavousi, Maryam, Leonard, Hampton L, Leong, Aaron, Mercader, Josep M, Morrison, Alanna C, Nadkarni, Girish N, Nalls, Mike A, Noordam, Raymond, Preuss, Michael, Smith, Jennifer A, Trompet, Stella, Vissink, Petra, Yao, Jie, Zhao, Wei, Boerwinkle, Eric, Goodarzi, Mark O, Gudnason, Vilmundur, Jukema, J Wouter, Kardia, Sharon LR, Loos, Ruth JF, Liu, Ching-Ti, Manning, Alisa K, Mook-Kanamori, Dennis, Pankow, James S, Picavet, H Susan J, Sattar, Naveed, Simonsick, Eleanor M, Verschuren, WM Monique, van Dijk, Ko Willems, Florez, Jose C, Rotter, Jerome I, Meigs, James B, Dupuis, Josée, and Udler, Miriam S

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Heart Disease, Prevention, Cardiovascular, Diabetes, Atherosclerosis, Digestive Diseases, Obesity, Nutrition, Genetics, Liver Disease, 2.1 Biological and endogenous factors, Metabolic and endocrine, Good Health and Well Being, Alleles, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Genetic Loci, Humans, Pharmaceutical Preparations, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveType 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D genetic loci using their associations with 47 diabetes-related traits and identified five clusters, termed β-cell, proinsulin, obesity, lipodystrophy, and liver/lipid. The relationship between these clusters and individual-level metabolic disease outcomes has not been assessed.Research design and methodsHere we constructed individual-level partitioned polygenic scores (pPS) for these five clusters in 12 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank (n = 454,193) and tested for cross-sectional association with T2D-related outcomes, including blood pressure, renal function, insulin use, age at T2D diagnosis, and coronary artery disease (CAD).ResultsDespite all clusters containing T2D risk-increasing alleles, they had differential associations with metabolic outcomes. Increased obesity and lipodystrophy cluster pPS, which had opposite directions of association with measures of adiposity, were both significantly associated with increased blood pressure and hypertension. The lipodystrophy and liver/lipid cluster pPS were each associated with CAD, with increasing and decreasing effects, respectively. An increased liver/lipid cluster pPS was also significantly associated with reduced renal function. The liver/lipid cluster includes known loci linked to liver lipid metabolism (e.g., GCKR, PNPLA3, and TM6SF2), and these findings suggest that cardiovascular disease risk and renal function may be impacted by these loci through their shared disease pathway.ConclusionsOur findings support that genetically driven pathways leading to T2D also predispose differentially to clinical outcomes.

Published
2022

8. Sociodemographic, lifestyle and clinical characteristics of energy-related depression symptoms: A pooled analysis of 13,965 depressed cases in 8 Dutch cohorts

Author

Vreijling, Sarah R., van Haeringen, Marije, Milaneschi, Yuri, Huider, Floris, Bot, Mariska, Amin, Najaf, Beulens, Joline W., Bremmer, Marijke A., Elders, Petra J., Galesloot, Tessel E., Kiemeney, Lambertus A., van Loo, Hanna M., Picavet, H. Susan J., Rutters, Femke, van der Spek, Ashley, van de Wiel, Anne M., van Duijn, Cornelia, Feskens, Edith J.M., Hartman, Catharina A., Oldehinkel, Albertine J., Smit, Jan H., Verschuren, W.M. Monique, Willemsen, Gonneke, de Geus, Eco J.C., Boomsma, Dorret I., Penninx, Brenda W.J.H., Lamers, Femke, and Jansen, Rick

Published
2023
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9. Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts

Author

Fraszczyk, Eliza, Spijkerman, Annemieke M. W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E. T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M. Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, and Snieder, Harold

Published
2022
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15. Association between metabolomics-based biomarker scores and 10-year cognitive decline in men and women. The Doetinchem Cohort Study.

Author

Smit, Annelot P, Herber, Gerrie-Cor M, Kuiper, Lieke M, Rietman, M Liset, Wesenhagen, Kirsten E J, Picavet, H Susan J, Slagboom, P Eline, and Verschuren, W M Monique

Subjects
LIPID metabolism, COGNITION disorders diagnosis, COGNITION disorder risk factors, MEN, RISK assessment, LIFESTYLES, WOMEN, RESEARCH funding, HEALTH status indicators, SEX distribution, COGNITIVE processing speed, MULTIPLE regression analysis, DESCRIPTIVE statistics, LONGITUDINAL method, COGNITION disorders, MEMORY, AGING, METABOLOMICS, MEDICAL care for older people, BIOMARKERS, COGNITIVE flexibility, COGNITION, PROTON magnetic resonance spectroscopy, PSYCHOSOCIAL factors, OLD age
Abstract

Background Metabolomic scores based on age (MetaboAge) and mortality (MetaboHealth) are considered indicators of overall health, but their association with cognition in the general population is unknown. Therefore, the association between MetaboAge/MetaboHealth and level and decline in cognition was studied, as were differences between men and women. Methods Data of 2821 participants (50% women, age range 45–75) from the Doetinchem Cohort Study was used. MetaboAge and MetaboHealth were calculated from 1H-NMR metabolomics data at baseline. Cognitive domain scores (memory, flexibility and processing speed) and global cognitive functioning were available over a 10-year period. The association between MetaboAge/MetaboHealth and level of cognitive functioning was studied using linear regressions while for the association between MetaboAge/MetaboHealth and cognitive decline longitudinal linear mixed models were used. Analyses were adjusted for demographics and lifestyle factors. Results Higher MetaboAge, indicating poorer metabolomic ageing, was only associated with lower levels of processing speed in men. Higher MetaboHealth, indicating poorer immune-metabolic health, was associated with lower levels of cognitive functioning for all three domains and global cognitive functioning in both men and women. Only in men, MetaboHealth was also associated with 10-year decline in flexibility, processing speed and global cognition. Metabolites that contributed to the observed associations were in men mainly markers of protein metabolism, and in women mainly markers of lipid metabolism and inflammatory metabolites. Conclusions MetaboHealth, not MetaboAge, was associated with cognitive functioning independent of conventional risk factors. Individual metabolites affect cognitive functioning differently in men and women, suggesting sex-specific pathophysiological pathways underlying cognitive functioning. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Self-Rated Health among Older Adults: Longitudinal Analyses Examining Sex Differences across Different Birth Cohorts and Educational Levels.

Author

Schaap, Laura A., Sialino, Lena D., de la Court, Feline, van Oostrom, Sandra H., Picavet, H. Susan J., Verschuren, W.M. Monique, Visser, Marjolein, and Wijnhoven, Hanneke A.H.

Subjects
OLDER people, GENERAL Health Questionnaire, COHORT analysis, EDUCATIONAL attainment, LONGITUDINAL method
Abstract

Introduction: Given the known female disadvantage in physical and mental health, this study aimed to investigate sex differences in self-rated health (SRH) among older adults, considering the longitudinal course by age, birth cohort, and educational level. Methods: Data from birth cohort 1911–1937 with baseline age 55–81 years (n = 3,107) and birth cohort 1938–1947 with baseline age 55–65 years (n = 1,002) from the Longitudinal Aging Study Amsterdam (LASA) were used. Mixed model analyses were used to examine sex differences in SRH (RAND General Health Perception Questionnaire [RAND-GHPQ], range 0–16) over the age course, testing for effect modification by the birth cohort and educational level (low, middle, high). Results: For both sexes, a decline in SRH was seen with increasing age. Over the age course, there was no significant sex difference in SRH within the older (1911–1937) birth cohort (0.13 lower score on SRH for women compared to men, 95% CI: −0.35 to 0.09) and only a small sex difference in the more recent (1938–1947) birth cohort (0.35 lower score on SRH for women compared to men [95% CI: −0.69 to −0.02], p = 0.04). There was no significant cohort difference in the size of the sex difference (p = 0.279). Those with a higher level of education reported a higher SRH, but between educational levels, there was no significant difference in the size of the sex difference in SRH. Discussion: In this study, no relevant sex difference in SRH over the age course was observed among older adults. Future research on SRH trajectories by sex during aging should take health-related, cognitive, psychosocial, and behavioral factors into account. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project

Author

Huider, Floris, primary, Milaneschi, Yuri, additional, Hottenga, Jouke-Jan, additional, Bot, Mariska, additional, Rietman, M. Liset, additional, Kok, Almar A.L., additional, Galesloot, Tessel E., additional, ‘t Hart, Leen M., additional, Rutters, Femke, additional, Blom, Marieke T., additional, Rhebergen, Didi, additional, Visser, Marjolein, additional, Brouwer, Ingeborg, additional, Feskens, Edith, additional, Hartman, Catharina A., additional, Oldehinkel, Albertine J., additional, de Geus, Eco J.C., additional, Kiemeney, Lambertus A., additional, Huisman, Martijn, additional, Picavet, H. Susan J., additional, Verschuren, W.M. Monique, additional, van Loo, Hanna M., additional, Penninx, Brenda W.J.H., additional, and Boomsma, Dorret I., additional

Published
2024
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20. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis

Author

Kocevska, Desana, Lysen, Thom S., Dotinga, Aafje, Koopman-Verhoeff, M. Elisabeth, Luijk, Maartje P. C. M., Antypa, Niki, Biermasz, Nienke R., Blokstra, Anneke, Brug, Johannes, Burk, Wiliam J., Comijs, Hannie C., Corpeleijn, Eva, Dashti, Hassan S., de Bruin, Eduard J., de Graaf, Ron, Derks, Ivonne P. M., Dewald-Kaufmann, Julia F., Elders, Petra J. M., Gemke, Reinoldus J. B. J., Grievink, Linda, Hale, Lauren, Hartman, Catharina A., Heijnen, Cobi J., Huisman, Martijn, Huss, Anke, Ikram, M. Arfan, Jones, Samuel E., Velderman, Mariska Klein, Koning, Maaike, Meijer, Anne Marie, Meijer, Kim, Noordam, Raymond, Oldehinkel, Albertine J., Groeniger, Joost Oude, Penninx, Brenda W. J. H., Picavet, H. Susan J., Pieters, Sara, Reijneveld, Sijmen A., Reitz, Ellen, Renders, Carry M., Rodenburg, Gerda, Rutters, Femke, Smith, Matt C., Singh, Amika S., Snijder, Marieke B., Stronks, Karien, ten Have, Margreet, Twisk, Jos W. R., Van de Mheen, Dike, van der Ende, Jan, van der Heijden, Kristiaan B., van der Velden, Peter G., van Lenthe, Frank J., van Litsenburg, Raphaële R. L., van Oostrom, Sandra H., van Schalkwijk, Frank J., Sheehan, Connor M., Verheij, Robert A., Verhulst, Frank C., Vermeulen, Marije C. M., Vermeulen, Roel C. H., Verschuren, W. M. Monique, Vrijkotte, Tanja G. M., Wijga, Alet H., Willemen, Agnes M., ter Wolbeek, Maike, Wood, Andrew R., Xerxa, Yllza, Bramer, Wichor M., Franco, Oscar H., Luik, Annemarie I., Van Someren, Eus J. W., and Tiemeier, Henning

Published
2021
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21. Past or Present; Which Exposures Predict Metabolomic Aging Better?: The Doetinchem Cohort Study

Author

Cardiovasculaire Epi Team 7a, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Smit, Annelot P, Herber, Gerrie-Cor M, Kuiper, Lieke M, Loef, Bette, Picavet, H Susan J, Verschuren, W M Monique, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Smit, Annelot P, Herber, Gerrie-Cor M, Kuiper, Lieke M, Loef, Bette, Picavet, H Susan J, and Verschuren, W M Monique

Published
2024

22. Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Huider, Floris, Milaneschi, Yuri, Hottenga, Jouke-Jan, Bot, Mariska, Rietman, M Liset, Kok, Almar A L, Galesloot, Tessel E, 't Hart, Leen M, Rutters, Femke, Blom, Marieke T, Rhebergen, Didi, Visser, Marjolein, Brouwer, Ingeborg, Feskens, Edith, Hartman, Catharina A, Oldehinkel, Albertine J, de Geus, Eco J C, Kiemeney, Lambertus A, Huisman, Martijn, Picavet, H Susan J, Verschuren, W M Monique, van Loo, Hanna M, Penninx, Brenda W J H, Boomsma, Dorret I, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Huider, Floris, Milaneschi, Yuri, Hottenga, Jouke-Jan, Bot, Mariska, Rietman, M Liset, Kok, Almar A L, Galesloot, Tessel E, 't Hart, Leen M, Rutters, Femke, Blom, Marieke T, Rhebergen, Didi, Visser, Marjolein, Brouwer, Ingeborg, Feskens, Edith, Hartman, Catharina A, Oldehinkel, Albertine J, de Geus, Eco J C, Kiemeney, Lambertus A, Huisman, Martijn, Picavet, H Susan J, Verschuren, W M Monique, van Loo, Hanna M, Penninx, Brenda W J H, and Boomsma, Dorret I

Published
2024

31. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study

Author

Freisling, Heinz, Viallon, Vivian, Lennon, Hannah, Bagnardi, Vincenzo, Ricci, Cristian, Butterworth, Adam S., Sweeting, Michael, Muller, David, Romieu, Isabelle, Bazelle, Pauline, Kvaskoff, Marina, Arveux, Patrick, Severi, Gianluca, Bamia, Christina, Kühn, Tilman, Kaaks, Rudolf, Bergmann, Manuela, Boeing, Heiner, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Dahm, Christina C., Menéndez, Virginia, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Santiuste, Carmen, Gurrea, Aurelio Barricarte, Tong, Tammy Y. N., Schmidt, Julie A., Tzoulaki, Ioanna, Tsilidis, Konstantinos K., Ward, Heather, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Ricceri, Fulvio, Panico, Salvatore, Picavet, H. Susan J., Bakker, Marije, Monninkhof, Evelyn, Nilsson, Peter, Manjer, Jonas, Rolandsson, Olov, Thysell, Elin, Weiderpass, Elisabete, Jenab, Mazda, Riboli, Elio, Vineis, Paolo, Danesh, John, Wareham, Nick J., Gunter, Marc J., and Ferrari, Pietro

Published
2020
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32. Sociodemographic, lifestyle and clinical characteristics of energy-related depression symptoms:A pooled analysis of 13,965 depressed cases in 8 Dutch cohorts

Author

Vreijling, Sarah R., van Haeringen, Marije, Milaneschi, Yuri, Huider, Floris, Bot, Mariska, Amin, Najaf, Beulens, Joline W., Bremmer, Marijke A., Elders, Petra J., Galesloot, Tessel E., Kiemeney, Lambertus A., van Loo, Hanna M., Picavet, H. Susan J., Rutters, Femke, van der Spek, Ashley, van de Wiel, Anne M., van Duijn, Cornelia, Feskens, Edith J.M., Hartman, Catharina A., Oldehinkel, Albertine J., Smit, Jan H., Verschuren, W. M.Monique, Willemsen, Gonneke, de Geus, Eco J.C., Boomsma, Dorret I., Penninx, Brenda W.J.H., Lamers, Femke, Jansen, Rick, Vreijling, Sarah R., van Haeringen, Marije, Milaneschi, Yuri, Huider, Floris, Bot, Mariska, Amin, Najaf, Beulens, Joline W., Bremmer, Marijke A., Elders, Petra J., Galesloot, Tessel E., Kiemeney, Lambertus A., van Loo, Hanna M., Picavet, H. Susan J., Rutters, Femke, van der Spek, Ashley, van de Wiel, Anne M., van Duijn, Cornelia, Feskens, Edith J.M., Hartman, Catharina A., Oldehinkel, Albertine J., Smit, Jan H., Verschuren, W. M.Monique, Willemsen, Gonneke, de Geus, Eco J.C., Boomsma, Dorret I., Penninx, Brenda W.J.H., Lamers, Femke, and Jansen, Rick

Abstract

Background: In a substantial subgroup of depressed patients, atypical, energy-related depression symptoms (e.g. increased appetite/weight, hypersomnia, loss of energy) tend to cluster with immuno-metabolic dysregulations (e.g. increased BMI and inflammatory markers). This clustering is proposed to reflect a more homogeneous depression pathology. This study examines to what extent energy-related symptoms are associated and share sociodemographic, lifestyle and clinical characteristics. Methods: Data were available from 13,965 participants from eight Dutch cohorts with DSM-5 lifetime major depression assessed by the Lifetime Depression Assessment Self-report (LIDAS) questionnaire. Information on four energy-related depression symptoms were extracted: energy loss, increased appetite, increased weight, and hypersomnia. Tetrachoric correlations between these symptoms, and associations of these symptoms with sociodemographic (sex, age, education), lifestyle (physical activity, BMI, smoking) and clinical characteristics (age of onset, episode duration, history, treatment and recency, and self-reported comorbidity) were computed. Results: Correlations between energy-related symptoms were overall higher than those with other depression symptoms and varied from 0.90 (increased appetite vs increased weight) to 0.11 (increased appetite vs energy loss). All energy-related symptoms were strongly associated with higher BMI and a more severe clinical profile. Patients with increased appetite were more often smokers, and only patients with increased appetite or weight more often had a self-reported diagnosis of PTSD (OR = 1.17, p = 2.91E-08) and eating disorder (OR = 1.40, p = 4.08E-17). Conclusions: The symptom-specific associations may have consequences for a profile integrating these symptoms, which can be used to reflect immuno-metabolic depression. They indicate the need to study immuno-metabolic depression at individual symptom resolution as a starting point.

Published
2023

33. Predictors of healthy physiological aging across generations in a 30-year population-based cohort study: the Doetinchem Cohort Study

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Loef, Bette, Herber, Gerrie Cor M., Wong, Albert, Janssen, Nicole A.H., Hoekstra, Jurriaan, Picavet, H. Susan J., Verschuren, W. M.Monique, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Loef, Bette, Herber, Gerrie Cor M., Wong, Albert, Janssen, Nicole A.H., Hoekstra, Jurriaan, Picavet, H. Susan J., and Verschuren, W. M.Monique

Published
2023

34. Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Kuijpers, Yunus, Picavet, H Susan J, de Rond, Lia, de Zeeuw-Brouwer, Mary-Lène, Rutkens, Ryanne, Gijsbers, Esther, Slits, Irene, Engelfriet, Peter, Buisman, Anne-Marie, Verschuren, W M Monique, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovascular Health, Kuijpers, Yunus, Picavet, H Susan J, de Rond, Lia, de Zeeuw-Brouwer, Mary-Lène, Rutkens, Ryanne, Gijsbers, Esther, Slits, Irene, Engelfriet, Peter, Buisman, Anne-Marie, and Verschuren, W M Monique

Published
2023

35. Sociodemographic, lifestyle and clinical characteristics of energy-related depression symptoms: A pooled analysis of 13,965 depressed cases in 8 Dutch cohorts

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Vreijling, Sarah R., van Haeringen, Marije, Milaneschi, Yuri, Huider, Floris, Bot, Mariska, Amin, Najaf, Bremmer, Marijke A., Elders, Petra J., Galesloot, Tessel E., Kiemeney, Lambertus A., van Loo, Hanna M., Picavet, H. Susan J., Rutters, Femke, van der Spek, Ashley, van de Wiel, Anne M., van Duijn, Cornelia, Feskens, Edith J.M., Hartman, Catharina A., Oldehinkel, Albertine J., Smit, Jan H., Verschuren, W. M.Monique, Willemsen, Gonneke, de Geus, Eco J.C., Boomsma, Dorret I., Penninx, Brenda W.J.H., Lamers, Femke, Jansen, Rick, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Vreijling, Sarah R., van Haeringen, Marije, Milaneschi, Yuri, Huider, Floris, Bot, Mariska, Amin, Najaf, Bremmer, Marijke A., Elders, Petra J., Galesloot, Tessel E., Kiemeney, Lambertus A., van Loo, Hanna M., Picavet, H. Susan J., Rutters, Femke, van der Spek, Ashley, van de Wiel, Anne M., van Duijn, Cornelia, Feskens, Edith J.M., Hartman, Catharina A., Oldehinkel, Albertine J., Smit, Jan H., Verschuren, W. M.Monique, Willemsen, Gonneke, de Geus, Eco J.C., Boomsma, Dorret I., Penninx, Brenda W.J.H., Lamers, Femke, and Jansen, Rick

Published
2023

36. Differences in the Mediating Role of HL in Socioeconomic Inequalities in Health Across Age Groups: Results from the Dutch Doetinchem Cohort Study

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Klokgieters, Silvia S., Picavet, H. Susan J., Huisman, Martijn, Monique Verschuren, W. M., Uiters, Ellen A.H., Kok, Almar A.L., Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Klokgieters, Silvia S., Picavet, H. Susan J., Huisman, Martijn, Monique Verschuren, W. M., Uiters, Ellen A.H., and Kok, Almar A.L.

Published
2023

37. Masculine gender affects sex differences in the prevalence of chronic health problems - The Doetinchem Cohort Study

Author

Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Vader, Sarah S, Lewis, Shirley M, Verdonk, Petra, Verschuren, W M Monique, Picavet, H Susan J, Cardiometabolic Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Vader, Sarah S, Lewis, Shirley M, Verdonk, Petra, Verschuren, W M Monique, and Picavet, H Susan J

Published
2023

38. Past or Present; Which Exposures Predict Metabolomic Aging Better? The Doetinchem Cohort Study.

Author

Smit, Annelot P, Herber, Gerrie-Cor M, Kuiper, Lieke M, Loef, Bette, Picavet, H Susan J, and Verschuren, W M Monique

Subjects
METABOLOMICS, COHORT analysis, OLDER men, AGE differences, AGING
Abstract

People age differently. Differences in aging might be reflected by metabolites, also known as metabolomic aging. Predicting metabolomic aging is of interest in public health research. However, the added value of longitudinal over cross-sectional predictors of metabolomic aging is unknown. We studied exposome-related exposures as potential predictors of metabolomic aging, both cross-sectionally and longitudinally in men and women. We used data from 4 459 participants, aged 36–75 of Round 4 (2003–2008) of the long-running Doetinchem Cohort Study (DCS). Metabolomic age was calculated with the MetaboHealth algorithm. Cross-sectional exposures were demographic, biological, lifestyle, and environmental at Round 4. Longitudinal exposures were based on the average exposure over 15 years (Round 1 [1987–1991] to 4), and trend in these exposure over time. Random Forest was performed to identify model performance and important predictors. Prediction performances were similar for cross-sectional and longitudinal exposures in both men (R 2 6.8 and 5.8, respectively) and women (R 2 14.8 and 14.4, respectively). Biological and diet exposures were most predictive for metabolomic aging in both men and women. Other important predictors were smoking behavior for men and contraceptive use and menopausal status for women. Taking into account history of exposure levels (longitudinal) had no added value over cross-sectionally measured exposures in predicting metabolomic aging in the current study. However, the prediction performances of both models were rather low. The most important predictors for metabolomic aging were from the biological and lifestyle domain and differed slightly between men and women. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Reduced Antibody Acquisition with Increasing Age following Vaccination with BNT162b2: Results from Two Longitudinal Cohort Studies in The Netherlands

Author

van den Hoogen, Lotus Leonie, primary, Boer, Mardi, additional, Postema, Abigail, additional, de Rond, Lia, additional, de Zeeuw-Brouwer, Mary-lène, additional, Pronk, Inge, additional, Wijmenga-Monsuur, Alienke Jentien, additional, Bijvank, Elske, additional, Kruiper, Caitlyn, additional, Beckers, Lisa, additional, Maurik, Marjan Bogaard-van, additional, Zutt, Ilse, additional, van Vliet, Jeffrey, additional, van Bergen, Rianne, additional, Kuijer, Marjan, additional, Smits, Gaby, additional, Verschuren, W. M. Monique, additional, Picavet, H. Susan J., additional, van der Klis, Fiona Regina Maria, additional, den Hartog, Gerco, additional, van Binnendijk, Robert Samuel, additional, and Buisman, Anne-Marie, additional

Published
2022
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46. Healthy lifestyle over the life course: Population trends and individual changes over 30 years of the Doetinchem Cohort Study

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Schermer, Edith E., Engelfriet, Peter M., Blokstra, Anneke, Verschuren, W. M.Monique, Picavet, H. Susan J., Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Schermer, Edith E., Engelfriet, Peter M., Blokstra, Anneke, Verschuren, W. M.Monique, and Picavet, H. Susan J.

Published
2022

47. Reduced Antibody Acquisition with Increasing Age following Vaccination with BNT162b2: Results from Two Longitudinal Cohort Studies in The Netherlands

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Public Health Practice, van den Hoogen, Lotus Leonie, Boer, Mardi, Postema, Abigail, de Rond, Lia, de Zeeuw-Brouwer, Mary lène, Pronk, Inge, Wijmenga-Monsuur, Alienke Jentien, Bijvank, Elske, Kruiper, Caitlyn, Beckers, Lisa, Maurik, Marjan Bogaard van, Zutt, Ilse, van Vliet, Jeffrey, van Bergen, Rianne, Kuijer, Marjan, Smits, Gaby, Verschuren, W. M.Monique, Picavet, H. Susan J., van der Klis, Fiona Regina Maria, den Hartog, Gerco, van Binnendijk, Robert Samuel, Buisman, Anne Marie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Public Health Practice, van den Hoogen, Lotus Leonie, Boer, Mardi, Postema, Abigail, de Rond, Lia, de Zeeuw-Brouwer, Mary lène, Pronk, Inge, Wijmenga-Monsuur, Alienke Jentien, Bijvank, Elske, Kruiper, Caitlyn, Beckers, Lisa, Maurik, Marjan Bogaard van, Zutt, Ilse, van Vliet, Jeffrey, van Bergen, Rianne, Kuijer, Marjan, Smits, Gaby, Verschuren, W. M.Monique, Picavet, H. Susan J., van der Klis, Fiona Regina Maria, den Hartog, Gerco, van Binnendijk, Robert Samuel, and Buisman, Anne Marie

Published
2022

48. Using random forest to identify longitudinal predictors of health in a 30-year cohort study

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Loef, Bette, Wong, Albert, Janssen, Nicole A.H., Strak, Maciek, Hoekstra, Jurriaan, Picavet, H. Susan J., Boshuizen, H. C.Hendriek, Verschuren, W. M.Monique, Herber, Gerrie Cor M., Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Loef, Bette, Wong, Albert, Janssen, Nicole A.H., Strak, Maciek, Hoekstra, Jurriaan, Picavet, H. Susan J., Boshuizen, H. C.Hendriek, Verschuren, W. M.Monique, and Herber, Gerrie Cor M.

Published
2022

49. Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Public Health Practice, Fraszczyk, Eliza, Spijkerman, Annemieke M.W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M.Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, Snieder, Harold, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Public Health Practice, Fraszczyk, Eliza, Spijkerman, Annemieke M.W., Zhang, Yan, Brandmaier, Stefan, Day, Felix R., Zhou, Li, Wackers, Paul, Dollé, Martijn E.T., Bloks, Vincent W., Gào, Xīn, Gieger, Christian, Kooner, Jaspal, Kriebel, Jennifer, Picavet, H. Susan J., Rathmann, Wolfgang, Schöttker, Ben, Loh, Marie, Verschuren, W. M.Monique, van Vliet-Ostaptchouk, Jana V., Wareham, Nicholas J., Chambers, John C., Ong, Ken K., Grallert, Harald, Brenner, Hermann, Luijten, Mirjam, and Snieder, Harold

Published
2022

50. Exploring the difference between men and women in physical functioning: How do sociodemographic, lifestyle- and health-related determinants contribute?

Author

Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Sialino, Lena Dirkje, Picavet, H. Susan J., Wijnhoven, Hanneke A.H., Loyen, Anne, Verschuren, W. M.Monique, Visser, Marjolein, Schaap, Laura S., van Oostrom, Sandra H., Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiometabolic Health, Sialino, Lena Dirkje, Picavet, H. Susan J., Wijnhoven, Hanneke A.H., Loyen, Anne, Verschuren, W. M.Monique, Visser, Marjolein, Schaap, Laura S., and van Oostrom, Sandra H.

Published
2022

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