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3. Optimizing aspirin dose for colorectal cancer patients through deep phenotyping using novel biomarkers of drug action.

Author

Patrignani, Paola, Tacconelli, Stefania, Contursi, Annalisa, Piazuelo, Elena, Bruno, Annalisa, Nobili, Stefania, Mazzei, Matteo, Milillo, Cristina, Hofling, Ulrika, Hijos-Mallada, Gonzalo, Sostres, Carlos, and Lanas, Angel

Subjects
TRANSCRIPTION factors, LIQUID chromatography-mass spectrometry, ANTINEOPLASTIC agents, COLON tumors, ASPIRIN, BLOOD platelet aggregation
Abstract

Background: Low-dose aspirin's mechanism of action for preventing colorectal cancer (CRC) is still debated, and the optimal dose remains uncertain. We aimed to optimize the aspirin dose for cancer prevention in CRC patients through deep phenotyping using innovative biomarkers for aspirin's action. Methods: We conducted a Phase II, open-label clinical trial in 34 CRC patients of both sexes randomized to receive enteric-coated aspirin 100 mg/d, 100 mg/BID, or 300 mg/d for 3 ± 1 weeks. Biomarkers were evaluated in blood, urine, and colorectal biopsies at baseline and after dosing with aspirin. Novel biomarkers of aspirin action were assessed in platelets and colorectal tissues using liquid chromatography-mass spectrometry to quantify the extent of cyclooxygenase (COX)-1 and COX-2 acetylation at Serine 529 and Serine 516, respectively. Results: All aspirin doses caused comparable % acetylation of platelet COX-1 at Serine 529 associated with similar profound inhibition of platelet-dependent thromboxane (TX)A2 generation ex vivo (serum TXB2) and in vivo (urinary TXM). TXB2 was significantly reduced in CRC tissue by aspirin 300 mg/d and 100 mg/BID, associated with comparable % acetylation of COX-1. Differently, 100 mg/day showed a lower % acetylation of COX-1 in CRC tissue and no significant reduction of TXB2. Prostaglandin (PG)E2 biosynthesis in colorectal tumors and in vivo (urinary PGEM) remained unaffected by any dose of aspirin associated with the variable and low extent of COX-2 acetylation at Serine 516 in tumor tissue. Increased expression of tumor-promoting genes like VIM (vimentin) and TWIST1 (Twist Family BHLH Transcription Factor 1) vs. baseline was detected with 100 mg/d of aspirin but not with the other two higher doses. Conclusion: In CRC patients, aspirin 300 mg/d or 100 mg/BID had comparable antiplatelet effects to aspirin 100 mg/d, indicating similar inhibition of the platelet's contribution to cancer. However, aspirin 300 mg/d and 100 mg/BID can have additional anticancer effects by inhibiting cancerous tissue's TXA2 biosynthesis associated with a restraining impact on tumor-promoting gene expression. EUDRACT number: 2018-002101-65. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Novel Drug-like HsrA Inhibitors Exhibit Potent Narrow-Spectrum Antimicrobial Activities against Helicobacter pylori.

Author

Casado, Javier, Olivan-Muro, Irene, Algarate, Sonia, Chueca, Eduardo, Salillas, Sandra, Velázquez-Campoy, Adrián, Piazuelo, Elena, Fillat, María F., Sancho, Javier, Lanas, Ángel, and González, Andrés

Subjects
HELICOBACTER pylori infections, HELICOBACTER pylori, CAMPYLOBACTER jejuni, PROTEIN synthesis, HUMAN microbiota
Abstract

Helicobacter pylori infection constitutes a silent pandemic of global concern. In the last decades, the alarming increase in multidrug resistance evolved by this pathogen has led to a marked drop in the eradication rates of traditional therapies worldwide. By using a high-throughput screening strategy, in combination with in vitro DNA binding assays and antibacterial activity testing, we identified a battery of novel drug-like HsrA inhibitors with MIC values ranging from 0.031 to 4 mg/L against several antibiotic-resistant strains of H. pylori, and minor effects against both Gram-negative and Gram-positive species of human microbiota. The most potent anti-H. pylori candidate demonstrated a high therapeutic index, an additive effect in combination with metronidazole and clarithromycin as well as a strong antimicrobial action against Campylobacter jejuni, another clinically relevant pathogen of phylum Campylobacterota. Transcriptomic analysis suggests that the in vivo inhibition of HsrA triggers lethal global disturbances in H. pylori physiology including the arrest of protein biosynthesis, malfunction of respiratory chain, detriment in ATP generation, and oxidative stress. The novel drug-like HsrA inhibitors described here constitute valuable candidates to a new family of narrow-spectrum antibiotics that allow overcoming the current resistome, protecting from dysbiosis, and increasing therapeutic options for novel personalized treatments against H. pylori. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Biomarkers of Response to Low-Dose Aspirin in Familial Adenomatous Polyposis Patients

Author

Lanas, Angel, primary, Tacconelli, Stefania, additional, Contursi, Annalisa, additional, Piazuelo, Elena, additional, Bruno, Annalisa, additional, Ronci, Maurizio, additional, Marcone, Simone, additional, Dovizio, Melania, additional, Sopeña, Federico, additional, Falcone, Lorenza, additional, Milillo, Cristina, additional, Mucci, Matteo, additional, Ballerini, Patrizia, additional, and Patrignani, Paola, additional

Published
2023
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7. Supplementary Figure 1 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

Author

Milicic, Anita, primary, Harrison, Lea-Anne, primary, Goodlad, Robert A., primary, Hardy, Robert G., primary, Nicholson, Anna M., primary, Presz, Michal, primary, Sieber, Oliver, primary, Santander, Sonia, primary, Pringle, James H., primary, Mandir, Nikki, primary, East, Philip, primary, Obszynska, Jolanta, primary, Sanders, Scott, primary, Piazuelo, Elena, primary, Shaw, Jacqui, primary, Harrison, Rebecca, primary, Tomlinson, Ian P., primary, McDonald, Stuart A.C., primary, Wright, Nicholas A., primary, and Jankowski, Janusz A.Z., primary

Published
2023
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8. Data from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

Author

Milicic, Anita, primary, Harrison, Lea-Anne, primary, Goodlad, Robert A., primary, Hardy, Robert G., primary, Nicholson, Anna M., primary, Presz, Michal, primary, Sieber, Oliver, primary, Santander, Sonia, primary, Pringle, James H., primary, Mandir, Nikki, primary, East, Philip, primary, Obszynska, Jolanta, primary, Sanders, Scott, primary, Piazuelo, Elena, primary, Shaw, Jacqui, primary, Harrison, Rebecca, primary, Tomlinson, Ian P., primary, McDonald, Stuart A.C., primary, Wright, Nicholas A., primary, and Jankowski, Janusz A.Z., primary

Published
2023
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9. Supplementary Figure 2 from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

Author

Milicic, Anita, primary, Harrison, Lea-Anne, primary, Goodlad, Robert A., primary, Hardy, Robert G., primary, Nicholson, Anna M., primary, Presz, Michal, primary, Sieber, Oliver, primary, Santander, Sonia, primary, Pringle, James H., primary, Mandir, Nikki, primary, East, Philip, primary, Obszynska, Jolanta, primary, Sanders, Scott, primary, Piazuelo, Elena, primary, Shaw, Jacqui, primary, Harrison, Rebecca, primary, Tomlinson, Ian P., primary, McDonald, Stuart A.C., primary, Wright, Nicholas A., primary, and Jankowski, Janusz A.Z., primary

Published
2023
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10. Supplementary Materials from Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

Author

Milicic, Anita, primary, Harrison, Lea-Anne, primary, Goodlad, Robert A., primary, Hardy, Robert G., primary, Nicholson, Anna M., primary, Presz, Michal, primary, Sieber, Oliver, primary, Santander, Sonia, primary, Pringle, James H., primary, Mandir, Nikki, primary, East, Philip, primary, Obszynska, Jolanta, primary, Sanders, Scott, primary, Piazuelo, Elena, primary, Shaw, Jacqui, primary, Harrison, Rebecca, primary, Tomlinson, Ian P., primary, McDonald, Stuart A.C., primary, Wright, Nicholas A., primary, and Jankowski, Janusz A.Z., primary

Published
2023
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11. 165 - ESTUDIO DE LOS CAMBIOS EN EL TRANSCRIPTOMA PLAQUETARIO ASOCIADOS AL DESARROLLO DE CÁNCER COLORRECTAL

Author

Piazuelo, Elena, primary, Arechavaleta, Samanta, additional, Hernández, María, additional, Domper, Mª José, additional, Hijos, Gonzalo, additional, Sánchez, Marta, additional, Sopeña, Federico, additional, Grasa, Laura, additional, Laredo, Viviana, additional, Alfaro, Enrique, additional, Roncalés, Pilar, additional, García-González, Mª Asunción, additional, and Lanas, Ángel, additional

Published
2023
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18. Blood-Cell-Based Inflammatory Markers as a Useful Tool for Early Diagnosis in Colorectal Cancer

Author

Hernandez-Ainsa, Maria, Velamazan, Raul, Lanas, Angel, Carrera-Lasfuentes, Patricia, and Piazuelo, Elena

Subjects
General Medicine
Abstract

BackgroundSystemic inflammation seems to be involved in the pathogenetic pathways of colorectal cancer (CRC). Analytical markers that reflect the inflammatory status, such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or systemic immune-inflammation index (SII), have been proposed as tools for the prognosis of CRC. Nevertheless, their use for diagnosis has been scarcely investigated.AimsTo analyze the ability of these markers and of a new marker combining SII and hemoglobin concentration, named NP/LHb = [neutrophils x platelets]/[lymphocytes x hemoglobin], as tools for CRC diagnosis. Furthermore, we studied their association with CRC-related variables.MethodsCase-control study including 214 CRC patients and 214 controls without CRC, matched by age (±5 years) and sex. We collected demographic, CRC-related and laboratory variables to calculate NLR, PLR, SII, and NP/LHb. In the case group, the laboratory variables were collected at two different period times, 6 months (IQR 4–8) before the CRC diagnosis and at the time of the diagnosis. ROC analysis was performed to evaluate the discriminatory accuracy of each index and we calculated Se, Sp, PPV, NPV, and OR to identify the diagnostic performance of each positive marker.ResultsNP/LHb showed high Sp (92.06%) and PPV (87.50%) to diagnose patients with CRC. This index exhibited an OR of 14.52 (8.26–25.52) and the best area under the curve (AUC: 0.78) for a positive CRC diagnosis. We found significant differences in all indices according to the presence of CRC, observing the highest values in CRC patients at time of diagnosis, in comparison with the analysis performed in the previous months to diagnosis or with control patients. There were significant differences in all ratios according to TNM stages (p < 0.05). PLR, SII and NP/LHb (but not NLR) showed significant differences according to tumor location (p < 0.05). Right-sided colon cancers presented the highest values, in comparison with left-sided and rectal cancers.ConclusionsSystemic inflammatory cell ratios (especially NP/LHb) change over time with the development of CRC, so they could be useful in its early diagnosis. We suggest that they could be routinely measured in patients with suspicion of CRC, to identify those ones with a higher risk of cancer, considering the high positive predictive value they have shown in our study.

Published
2021

19. Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease

Author

García-González, María Asunción, Bujanda, Luis, Quintero, Enrique, Santolaria, Santos, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Thomson, Concha, Pérez-Aisa, Angeles, Nicolás-Pérez, David, Hijona, Elizabeth, Carrera-Lasfuentes, Patricia, Piazuelo, Elena, Jiménez, Pilar, Espinel, Jesús, Campo, Rafael, Manzano, Marisa, Geijo, Fernando, Pellise, María, Zaballa, Manuel, González-Huix, Ferrán, Espinós, Jorge, Titó, Llúcia, Barranco, Luis, Pazo-Cid, Roberto, and Lanas, Angel

Published
2015
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27. Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype

Author

García-González, M Asunción, Quintero, Enrique, Bujanda, Luis, Nicolás, David, Benito, Rafael, Strunk, Mark, Santolaria, Santos, Sopeña, Federico, Badía, María, Hijona, Elizabeth, Pérez-Aísa, M Angeles, Méndez-Sánchez, Isabel M, Thomson, Concha, Carrera, Patricia, Piazuelo, Elena, Jiménez, Pilar, Espinel, Jesús, Campo, Rafael, Manzano, Marisa, Geijo, Fernando, Pellisé, Maria, González-Huix, Ferrán, Espinós, Jorge, Titó, LLusia, Zaballa, Manuel, Pazo, Roberto, and Lanas, Angel

Published
2012
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32. Gastric Cancer Susceptibility Is Not Linked to Pro-and Anti-Inflammatory Cytokine Gene Polymorphisms in Whites: A Nationwide Multicenter Study in Spain

Author

García-González, María Asunción, Lanas, Angel, Quintero, Enrique, Nicolás, David, Parra-Blanco, Adolfo, Strunk, Mark, Benito, Rafael, Simón, Miguel Angel, Santolaria, Santos, Sopeña, Federico, Piazuelo, Elena, Jiménez, Pilar, Pascual, Cristina, Mas, Eva, Irún, Pilar, Espinel, Jesús, Campo, Rafael, Manzano, Marisa, Geijo, Fernando, Pellisé, Maria, González-Huix, Ferrán, Nieto, Miguel, Espinós, Jorge, Titó, LLúcia, Bujanda, Luis, and Zaballa, Manuel

Published
2007

34. Relevance of DNA repair gene polymorphisms to gastric cancer risk and phenotype

Author

Carrera-Lasfuentes, Patricia, primary, Lanas, Angel, additional, Bujanda, Luis, additional, Strunk, Mark, additional, Quintero, Enrique, additional, Santolaria, Santos, additional, Benito, Rafael, additional, Sopeña, Federico, additional, Piazuelo, Elena, additional, Thomson, Concha, additional, Pérez-Aisa, Angeles, additional, Nicolás-Pérez, David, additional, Hijona, Elizabeth, additional, Espinel, Jesús, additional, Campo, Rafael, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellise, María, additional, Zaballa, Manuel, additional, González-Huix, Ferrán, additional, Espinós, Jorge, additional, Titó, Llúcia, additional, Barranco, Luis, additional, D'Amato, Mauro, additional, and García-González, María Asunción, additional

Published
2017
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36. 861 Genetic Susceptibility and Family History of Colorectal Cancer. Relevance of Single Nucleotide Polymorphisms in the Development of Preneoplastic Lesions in First-Degree Relatives of Patients With Colorectal Cancer

Author

Gargallo, Carla J., primary, Lanas, Angel, additional, Carrera, Patricia, additional, Ferrandez, Angel, additional, Quintero, Enrique, additional, Carrillo-Palau, Marta, additional, Alonso-Abreu, Inmaculada, additional, Arechavaleta, Samantha, additional, Montero, Jessica, additional, Piazuelo, Elena, additional, and García, Asunción, additional

Published
2016
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37. 1068 Direct Evidence for Long-Lasting Acetylation of Cyclooxygenase-1 Associated With Reduction of Colorectal Mucosa Prostaglandin E2 Levels and Ribosomal Protein S6 Phosphorylation by Low-Dose Aspirin in Subjects Undergoing Colorectal Cancer Screening

Author

Patrignani, Paola, primary, Sacco, Angela, additional, Sostres, Carlos, additional, Bruno, Annalisa, additional, Dovizio, Melania, additional, Piazuelo, Elena, additional, Di Francesco, Luigia, additional, Schiavone, Simone, additional, Tacconelli, Stefania, additional, Ferrandez, Angel, additional, Patrono, Carlo, additional, and Lanas, Angel, additional

Published
2016
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38. 290 Relevance of DNA Repair Polymorphisms As Genetic Markers of Gastric Cancer Susceptibility and Prognosis in Caucasians

Author

García-González, Maria Asuncion, primary, Bujanda, Luis, additional, Quintero, Enrique, additional, Santolaria, Santos, additional, Benito, Rafael, additional, Strunk, Mark, additional, Sopena, Federico, additional, Thomson, Concepción, additional, Aisa, Angeles Perez, additional, Nicolás-Pérez, David, additional, Hijona, Elizabeth, additional, Carrera, Patricia, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Espinel, Jesus, additional, Campo, Rafael, additional, Manzano, Maria Luisa, additional, Geijo, Fernando, additional, Pellise, Maria, additional, Zaballa, Manuel, additional, González-Huix, Ferran, additional, Espinos, Jorge C., additional, Titó, LLúcia, additional, Barranco, Luis E., additional, Pazo-Cid, Roberto A., additional, and Lanas, Angel, additional

Published
2015
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40. Association ofPSCArs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease

Author

García-González, María Asunción, primary, Bujanda, Luis, additional, Quintero, Enrique, additional, Santolaria, Santos, additional, Benito, Rafael, additional, Strunk, Mark, additional, Sopeña, Federico, additional, Thomson, Concha, additional, Pérez-Aisa, Angeles, additional, Nicolás-Pérez, David, additional, Hijona, Elizabeth, additional, Carrera-Lasfuentes, Patricia, additional, Piazuelo, Elena, additional, Jiménez, Pilar, additional, Espinel, Jesús, additional, Campo, Rafael, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellise, María, additional, Zaballa, Manuel, additional, González-Huix, Ferrán, additional, Espinós, Jorge, additional, Titó, Llúcia, additional, Barranco, Luis, additional, Pazo-Cid, Roberto, additional, and Lanas, Angel, additional

Published
2015
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44. Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma

Author

Medicina, Medikuntza, García-González, María Asunción, Nicolás-Pérez, David, Lanas, Ángel, Bujanda Fernández de Pierola, Luis, Carrera, Patricia, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Santolaria, Santos, Piazuelo, Elena, Jiménez, Pilar, Campo, Rafael, Espinel, Jesús, Manzano, Marisa, Geijo, Fernando, Pellisé, María, González-Huix, Ferrán, Espinós, Jorge, Zaballa, Manuel, Titó, Llúcia, Barranco, Luis, Pazo, Roberto, Quintero, Enrique, Medicina, Medikuntza, García-González, María Asunción, Nicolás-Pérez, David, Lanas, Ángel, Bujanda Fernández de Pierola, Luis, Carrera, Patricia, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Santolaria, Santos, Piazuelo, Elena, Jiménez, Pilar, Campo, Rafael, Espinel, Jesús, Manzano, Marisa, Geijo, Fernando, Pellisé, María, González-Huix, Ferrán, Espinós, Jorge, Zaballa, Manuel, Titó, Llúcia, Barranco, Luis, Pazo, Roberto, and Quintero, Enrique

Abstract

11 p., Background: Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC. -- Methodology: Genomic DNA from 380 Spanish Caucasian patients with primary GAC was genotyped for 23 polymorphisms in pro-inflammatory (IL1B, TNFA, LTA, IL6, IL12p40), anti-inflammatory (IL4, IL1RN, IL10, TGFB1) cytokine, and cyclooxygenase (PTGS1 and PTGS2) genes by PCR, RFLP and TaqMan assays. Clinical and histological information was collected prospectively. Survival curves were estimated by the Kaplan-Meier method and compared using the log rank test. Outcome was determined by analysis of Cox proportional hazards, adjusting for confounding factors. -- Results: The median follow-up period and median overall survival (OS) time were 9.9 months (range 0.4-120.3) and 10.9 months (95% CI: 8.9-14.1), respectively. Multivariate analysis identified tumor stages III (HR, 3.23; 95% CI: 2-5.22) and IV (HR, 5.5; 95% CI: 3.51-8.63) as independent factors associated with a significantly reduced OS, whereas surgical treatment (HR: 0.44; 95% CI: 0.3-0.6) was related to a better prognosis of the disease. Concerning genetic factors, none of the 23 polymorphisms evaluated in the current study did influence survival. Moreover, no gene-environment interactions on GAC prognosis were observed. -- Conclusions: Our results show that, in our population, the panel of selected pro-and anti-inflammatory cytokine, and cyclooxygenase gene polymorphisms are not relevant in determining the prognosis of gastric adenocarcinoma.

Published
2012

45. Prognostic role of host cyclooxygenase and cytokine genotypes in a caucasian cohort of patients with gastric adenocarcinoma

Author

García-González, M. Asunción, Nicolás-Pérez, David, Lanas, Ángel, Bujanda, Luis, Carrera, Patricia, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Santolaria, Santos, Piazuelo, Elena, Jiménez, Pilar, Campo, Rafael, Espinel, Jesús, Manzano, Marisa, Geijo, Fernando, Pellisé, María, González-Huix, Ferran, Espinós, Jorge, Zaballa, Manuel, Tito, Llucia, Barranco, Luis, Pazo, Roberto, Quintero, Enrique, García-González, M. Asunción, Nicolás-Pérez, David, Lanas, Ángel, Bujanda, Luis, Carrera, Patricia, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Santolaria, Santos, Piazuelo, Elena, Jiménez, Pilar, Campo, Rafael, Espinel, Jesús, Manzano, Marisa, Geijo, Fernando, Pellisé, María, González-Huix, Ferran, Espinós, Jorge, Zaballa, Manuel, Tito, Llucia, Barranco, Luis, Pazo, Roberto, and Quintero, Enrique

Abstract

Background: Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC. Methodology: Genomic DNA from 380 Spanish Caucasian patients with primary GAC was genotyped for 23 polymorphisms in pro-inflammatory (IL1B, TNFA, LTA, IL6, IL12p40), anti-inflammatory (IL4, IL1RN, IL10, TGFB1) cytokine, and cyclooxygenase (PTGS1 and PTGS2) genes by PCR, RFLP and TaqMan assays. Clinical and histological information was collected prospectively. Survival curves were estimated by the Kaplan-Meier method and compared using the log rank test. Outcome was determined by analysis of Cox proportional hazards, adjusting for confounding factors. Results: The median follow-up period and median overall survival (OS) time were 9.9 months (range 0.4-120.3) and 10.9 months (95% CI: 8.9-14.1), respectively. Multivariate analysis identified tumor stages III (HR, 3.23; 95% CI:2-5.22) and IV (HR, 5.5; 95% CI: 3.51-8.63) as independent factors associated with a significantly reduced OS, whereas surgical treatment (HR: 0.44; 95%CI: 0.3-0.6) was related to a better prognosis of the disease. Concerning genetic factors, none of the 23 polymorphisms evaluated in the current study did influence survival. Moreover, no gene-environment interactions on GAC prognosis were observed. Conclusions: Our results show that, in our population, the panel of selected pro- and anti-inflammatory cytokine, and cyclooxygenase gene polymorphisms are not relevant in determining the prognosis of gastric adenocarcinoma. © 2012 García-González et al.

Published
2012

46. Mo1122 Relevance of Psca Rs2294008 Gene Polymorphism on Gastric Cancer Risk and Prognosis

Author

Garcia-Gonzalez, Maria Asuncion, primary, Bujanda, Luis, additional, Quintero, Enrique, additional, Nicolás-Pérez, David, additional, Strunk, Mark, additional, Sopena, Federico, additional, Santolaria, Santos, additional, Thomson, Concepción, additional, Aisa, Angeles Perez, additional, Méndez-Sánchez, Isabel María, additional, Badia, Maria, additional, Hijona, Elizabeth, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Campo, Rafael, additional, Espinel, Jesus, additional, Manzano, Maria Luisa, additional, Geijo, Fernando, additional, Pellise, Maria, additional, Zaballa, Manuel, additional, González-Huix, Ferrán, additional, Espinos, Jorge C., additional, Barranco, Luis E., additional, Titó, LLúcia, additional, Pazo-Cid, Roberto A., additional, and Lanas, Angel, additional

Published
2013
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47. Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma

Author

García-González, María Asunción, primary, Nicolás-Pérez, David, additional, Lanas, Angel, additional, Bujanda, Luis, additional, Carrera, Patricia, additional, Benito, Rafael, additional, Strunk, Mark, additional, Sopeña, Federico, additional, Santolaria, Santos, additional, Piazuelo, Elena, additional, Jiménez, Pilar, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellisé, María, additional, González-Huix, Ferrán, additional, Espinós, Jorge, additional, Zaballa, Manuel, additional, Titó, Llúcia, additional, Barranco, Luis, additional, Pazo, Roberto, additional, and Quintero, Enrique, additional

Published
2012
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48. Su1854 Association of TP53 Arg72pro Variants With Gastric Cancer Risk in Helicobacter pylori Infected Subjects: A Nation-Wide Case-Control Study in Spain

Author

Garcia-Gonzalez, Maria Asuncion, primary, Quintero, Enrique, additional, Bujanda, Luis, additional, Nicolás-Pérez, David, additional, Benito, Rafael, additional, Strunk, Mark, additional, Santolaria, Santos, additional, Sopena, Federico, additional, Badia, Maria, additional, Hijona, Elizabeth, additional, Thomson, Concepción, additional, Aisa, Angeles Perez, additional, Méndez-Sánchez, Isabel María, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Zaballa, Manuel, additional, Espinel, Jesus, additional, Geijo, Fernando, additional, Pellise, Maria, additional, Campo, Rafael, additional, Manzano, Marisa, additional, González-Huix, Ferrán, additional, Espinos, Jorge C., additional, Titó, LLúcia, additional, Cid, Roberto A. Pazo, additional, Barranco, Luis, additional, and Lanas, Angel, additional

Published
2012
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49. Relevance of DNA Repair Gene Polymorphisms on Gastric Cancer Susceptibility and Phenotype

Author

Garcia-Gonzalez, Maria Asuncion, primary, Quintero, Enrique, additional, Bujanda, Luis, additional, Nicolás-Pérez, David, additional, Benito, Rafael, additional, Strunk, Mark, additional, Santolaria, Santos, additional, Sopena, Federico, additional, Badia, Maria, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Espinel, Jesus, additional, Campo, Rafael, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellise, Maria, additional, González-Huix, Ferrán, additional, Espinós, Jorge C., additional, Titó, LLúcia, additional, Zaballa, Manuel, additional, Méndez-Sánchez, Isabel María, additional, Perez Aisa, Angeles, additional, Thomson, Concepción, additional, Pazo, Roberto, additional, and Lanas, Angel, additional

Published
2011
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