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The 'Ornamental Stones of Piemonte Region' geo-lithological map at 1:250,000 scale aims at reviewing the ornamental stone heritage of Piemonte at the regional scale. The map derives from a thorough revision of the available literature, integrated with some unpublished original data. The map shows the location of the main quarries of ornamental stones of the region, selected on the basis of their historical, cultural and architectonic relevance. A geo-lithological basemap was produced, deriving it from a basic Geological Map of Piemonte, available at the same scale. The large varieties of lithotypes of Piemonte have been resumed, in the new map, into 21 classes, which all the ornamental stones have been assigned to. The Main Map is enriched by some significant examples of using the ornamental stones in historical buildings, and it is supported by a supplementary data base containing essential information about the quarry sites and the quarried material.

This contribution describes a geodatabase structure designed to manage a large amount of geo-environmental data for the "Gronda di Genova" highway by-pass tunnels in Liguria region (Italy). In particular, an innovative dataset structure founded on an explicit conceptual model was designed to represent the distribution of petrofacies containing Natural Occurring Asbestos (NOA), and their minero-chemical composition. This in order to assess the environmental risk (air dispersion of fibers) due to the tunnel excavation in the asbestos-bearing rocks. Problems related to the GIS (shp) - AutoCAD (layer) conversion have been also considered for delivering the graphic layout of the project and are here discussed.

The presence of naturally occurring asbestos (NOA) in many areas worldwide requires an enhanced geological risk evaluation to ensure workplace safety from asbestos during large construction projects. Due to the complexity of the geological risk definition, health and safety regulations for working with asbestos-bearing materials are often not enforceable in NOA settings. Therefore, to correctly estimate the risk of NOA in these scenarios, new procedures are urgently needed to provide (1) a detailed geological model representative of the possible presence of the asbestos, (2) representative sampling, and (3) a reliable quantitative determination of asbestos content in rocks. This work aims to discuss the improvements on the two latter points specifically developed during the design of the “Gronda di Genova” project, a 50-km-long tunnel bypass partially designed in the NOA-bearing meta-ophiolites of the Ligurian Alps and ophiolites of the northern Apennines in Italy. Implementation of Gy's theory on sampling was used to maintain statistical validity during sample processing from the primary sample to the analytical sample and is here described. The scanning electron microscopy/energy dispersive spectroscopy procedure for the quantification of NOA was improved with an error analysis delivering the minimum number of fibers to be measured to achieve the best analytical results.

BackgroundPrevious studies showed that the epidemic of carbapenem-resistant Klebsiella pneumoniae (CR-KP) observed in Italy since 2010 was sustained mostly by strains of clonal group (CG) 258 producing KPC-type carbapenemases. In the framework of the National Antibiotic-Resistance Surveillance (AR-ISS), a countrywide survey was conducted in 2016 to explore the evolution of the phenotypic and genotypic characteristics of CR-KP isolates.MethodsFrom March to July 2016, hospital laboratories participating in AR-ISS were requested to provide consecutive, non-duplicated CR-KP (meropenem and/or imipenem MIC >1 mg/L) from invasive infections. Antibiotic susceptibility was determined according to EUCAST recommendations. A WGS approach was adopted to characterize the isolates by investigating phylogeny, resistome and virulome.ResultsTwenty-four laboratories provided 157 CR-KP isolates, of which 156 were confirmed as K. pneumoniae sensu stricto by WGS and found to carry at least one carbapenemase-encoding gene, corresponding in most cases (96.1%) to blaKPC. MLST- and SNP-based phylogeny revealed that 87.8% of the isolates clustered in four major lineages: CG258 (47.4%), with ST512 as the most common clone, CG307 (19.9%), ST101 (15.4%) and ST395 (5.1%). A close association was identified between lineages and antibiotic resistance phenotypes and genotypes, virulence traits and capsular types. Colistin resistance, mainly associated with mgrB mutations, was common in all major lineages except ST395.ConclusionsThis WGS-based survey showed that, although CG258 remained the most common CR-KP lineage in Italy, a polyclonal population has emerged with the spread of the new high-risk lineages CG307, ST101 and ST395, while KPC remained the most common carbapenemase.

Asbestos may constitute a severe health risk when meta-ophiolites are excavated for large infrastructural projects. For public acceptance, a reliable estimation of the content of Naturally Occurring Asbestos (NOA) is necessary for the design of construction sites, workers' safety and spoil management. In the framework of a research project supporting the final design of a highway tunnel system in NW Italy, SEM-EDS (Scanning Electron Microscopy – Energy-Dispersive Spectrometry) quantitative analyses were performed to provide a direct NOA content estimation by counting and weighing the asbestos fibers in the rocks, after a chemical and geometrical characterization. The direct NOA content estimation was compared with an indirect estimation obtained through a fracture network modeling based on a structural survey on a selected outcrop and statistical analysis of a relative digital image. The fracture intensity, inferred from the fracture network model, was multiplied by coefficients deriving from the semi-quantitative estimation of the geological relations between asbestos mineral occurrence and fracture size, thickness and distribution. A good agreement between the indirect NOA estimation and the average result of the SEM-EDS analysis was obtained. Thus, the statistical analysis of the fracture network may represent a valuable support to the SEM-EDS quantitative analysis based on mineral fibers counting. However, the quality of the indirect NOA estimation depends on the postulates for inferring the coefficients describing the distribution and occurrence of the asbestos minerals within the fractures. This Note discusses the above-mentioned issues, as well as those concerning the procedure for a representative sampling of NOA-bearing rocks and fractures.

Naturally-Occurring Asbestos (NOA) may constitute a severe health risk when metamorphic rocks are excavated for large infrastructure projects. For public acceptance, a reliable assessment of the content of NOA is necessary for the design of the construction site, workers’ safety, and spoil management. Direct measurements of NOA content can be made by SEM-EDS analyses on an adequate number of samples. Such measurements are sufficiently precise but questions about the representativity of the samples may arise, especially when the rock units are structurally and lithologically complex. Therefore, in order to corroborate the direct assessments, alternative and indirect assessments can be performed by measuring the fracture volumetric porosity, provided that almost all the NOA is deposited as veins in the fractures of the rock mass. Statistical sampling and inference procedures can be applied to derive such an index. In this paper, an indirect assessment of NOA is reported and compared with the assessment obtained by direct measurements. The application is to a metamorphic rock formation through which a tunnel is to be driven as part of the ”Gronda di Genova” highway development in Genoa, Italy. Even though significant approximations are made, the indirect assessment is relatively close to the direct measurement.

In SW Piemonte the Western Alps arc ends off in a narrow, E-W trending zone, where some geological domains of the Alps converged. Based on a critical review of available data, integrated with new field data, it is concluded that the southern termination of Western Alps recorded the Oligocene-Miocene activity of a regional transfer zone (southwestern Alps Transfer, SWAT) already postulated in the literature, which should have allowed, since early Oligocene, the westward indentation of Adria, while the regional shortening of SW Alps and tectonic transport toward the SSW (Dauphinois foreland) was continuing. This transfer zone corresponds to a system of deformation units and km-scale shear zones (Gardetta-Viozene Zone, GVZ). The GVZ/SWAT developed externally to the Penninic Front (PF), here corresponding to the Internal Briançonnais Front (IBF), which separates the Internal Briançonnais domain, affected by major tectono-metamorphic transformations, from the External Briançonnais, subjected only to anchizonal metamorphic conditions. The postcollisional evolution of the SW Alps axial belt units was recorded by the Oligocene to Miocene inner syn-orogenic basin (Tertiary Piemonte Basin, TPB), which rests also on the Ligurian units stacked within the adjoining Apennines belt in southern Piemonte. The TPB successions were controlled by transpressive faults propagating (to E and NE) from the previously formed Alpine belt, as well as by the Apennine thrusts that were progressively stacking the Ligurian units, resting on the subducting Adriatic continental margin, with the TPB units themselves. This allows correlation between Alps and Apennines kinematics, in terms of age of the main geologic events, interference between the main structural systems and tectonic control exerted by both tectonic belts on the same syn-orogenic basin.

In the Maritime Alps (NW Italy - SE France), the Middle Triassic-Berriasian platform carbonates of the Provençal Domain are locally affected by an intense hydrothermal dolomitization. This dolomitization resulted from a large-scale hydrothermal circulation related to deep-rooted faults, and is indirect evidence of a significant earliest Cretaceous fault activity in this part of the Alpine Tethys European palaeomargin. New carbonate U-Pb dating and geochemical (stable isotope and noble gases on inclusion-hosted water, 87Sr/86Sr, clumped isotopes) data allowed a better understanding of the timing and mechanisms of the hydrothermal circulation. Hydrothermal fluids probably originated from seawater, which was involved in a deep circulation within the underlying crystalline basement, undergoing heating to more than 200°C and substantial compositional modification by prolonged interaction with basement rocks. Thin cement rims rich in carbonaceous material, locally alternated with hydrothermal dolomite cements, are interpreted as remnants of ephemeral microbial communities that could colonize the upper part of hydrothermal conduits during periods of reduced hot fluid flow and contemporaneous downward seawater infiltration.

For a reliable evaluation of the geo-environmental risk due to naturally occurring asbestos (NOA) during rock excavation of large infrastructure projects, a proper procedure is needed. First, it is necessary to provide a detailed geological model tailored to the NOA-related issues that should drive the rock sampling procedures in order to obtain a representative sampling. The sampling procedures should take into account lithological variability and relative spatial distributions of the rock units. The geological model for NOA should be thus constrained by the main NOA petrofacies occurring in a given geotectonic context, which take into consideration both the mineralogical and structural features, and the identification of NOA homogeneous zones in which the NOA petrofacies are distributed. In this paper, some geo-environmental problems faced during the excavation, in meta-ophiolites, of a long highway tunnel are described. The geological model of the complex setting of the tunnel area (northern Italy, Alps-Apennines junction) is described, focusing on how the NOA-related problems were addressed to allow reliable and detailed estimations of NOA contents for each NOA homogeneous zone and the relevant tunnel layout segment.

Naturally-Occurring Asbestos (NOA) may constitute a severe health risk when metamorphic rocks are excavated for large infrastructure projects. For public acceptance, a reliable assessment of the content of NOA is necessary for the design of the construction site, workers' safety, and spoil management. Direct measurements of NOA content can be made by SEM-EDS analyses on an adequate number of samples. Such measurements are sufficiently precise but questions about the representativity of the samples may arise, especially when the rock units are structurally and lithologically complex. Therefore, in order to corroborate the direct assessments, alternative and indirect assessments can be performed by measuring the fracture volumetric porosity, provided that almost all the NOA is deposited as veins in the fractures of the rock mass. Statistical sampling and inference procedures can be applied to derive such an index. In this paper, an indirect assessment of NOA is reported and compared with the assessment obtained by direct measurements. The application is to a metamorphic rock formation through which a tunnel is to be driven as part of the "Gronda di Genova" highway development in Genoa, Italy. Even though significant approximations are made, the indirect assessment is relatively close to the direct measurement.

Realization of large geo-engineering projects in rocks containing naturally occurring asbestos (NOA) must address several crucial geo-environmental issues, including the design of the construction site, the enforcement of health protection measures and the environmentally responsible spoil management. This leads to a compelling need to develop effective and standard procedures to evaluate the distribution and concentration of NOA in rock volumes. NOA petrofacies are here proposed as an innovative tool to evaluate the asbestos distribution and concentration in complex geological settings. NOA petrofacies are fundamental asbestos-bearing rock types, consisting in recurrent lithological and structural features controlling asbestos occurrence. Here we describe and discuss how the NOA petrofacies approach was utilized in a geo-environmental study for the evaluation of asbestos content in a complex meta-ophiolite suite, which will be crossed by the “Gronda di Genova” highway by-pass project (Genoa, NW Italy). NOA petrofacies were used to predict the distribution and relative abundance of NOA in geologically homogeneous zones characterized by the occurrence of specific NOA minerals.

This paper presents an ontology-driven representation of knowledge for geological maps. The ontological formal language allows for a machine-readable encoding of the Earth scientist's interpretation through semantic categories and properties and is credited to support knowledge sharing and interoperability. We introduce an ontology-driven method for the interpretation and the encoding of the map data that employs shared vocabularies and resources encoded through ontologies in order to prevent the use of ambiguous terms. The approach relies on a computational ontology of the geological knowledge (OntoGeonous), which formalizes a number of geological knowledge sources (including GeoScienceML), to guide the interpretation process. The design of the database underlying the map (OntoGeoBase) constrains the process of data entry to refer to the terminology conveyed by the taxonomic-axiomatic nature of the ontology. This reduces the amount of implicit knowledge favouring a conceptual alignment of the ancillary documentation with the map, leading to a better comprehension of map and allowing the traceability of the interpretation.

This paper introduces a novel, semantics-informed geologic mapping process, whose application domain is the production of a synthetic geologic map of a large administrative region. A number of approaches concerning the expression of geologic knowledge through UML schemata and ontologies have been around for more than a decade. These approaches have yielded resources that concern specific domains, such as, e.g., lithology. We develop a conceptual model that aims at building a digital encoding of several domains of geologic knowledge, in order to support the interoperability of the sources. We apply the devised terminological base to the classification of the elements of a geologic map of the Italian Western Alps and northern Apennines (Piemonte region). The digitally encoded knowledge base is a merged set of ontologies, called OntoGeonous. The encoding process identifies the objects of the semantic encoding, the geologic units, gathers the relevant information about such objects from authoritative resources, such as GeoSciML (giving priority to the application schemata reported in the INSPIRE Encoding Cookbook), and expresses the statements by means of axioms encoded in the Web Ontology Language (OWL). To support interoperability, OntoGeonous interlinks the general concepts by referring to the upper part level of ontology SWEET (developed by NASA), and imports knowledge that is already encoded in ontological format (e.g., ontology Simple Lithology). Machine-readable knowledge allows for consistency checking and for classification of the geological map data through algorithms of automatic reasoning.

The chapter discusses the important role of packaging as part of a company’s market and operations management. Packaging has been evolving for centuries and continues to do so, forcing consumers to change their habits. From simple protection tools to safeguarding carried items, packaging has become a marketing and communication instrument as important as contents. E-commerce and onlineretailers growth change again the packaging role during purchasing, bring it back as mere logistics and protection tool. In the first basic section, a brief history of packaging is described. Starting from the most important steps, which characterize packaging from the very beginning, in prehistory, followed by the commercial discoveries of the Middle Ages, the industrial revolution, until the present day with the newest and most ingenious packaging solutions. With a focus on marketing, design, logistics, environmental impact, and costs, a complete reference framework underlining how each of these aspects change along the supply chain steps is presented. The advanced and second section of the chapter presents case studies, models and methods for packaging costs evaluation and unit load design. Logistics and packaging are fundamental business leverages for a modern company, therefore any improvements can represent opportunities and generate profits. The chapter ends with a discussion about state-of -the-art research in packaging: the last decade showed a strong development of the e-commerce market, and the central role of packaging changed. Furthermore, the evolution of technologies, materials and Internet Communication Technologies in the last few years have improved the packaging world as well creating, for example, intelligent packaging that can communicate with consumers or interact with products, allowing the traceability of a single item within the entire supply chain. Packaging is a fundamental resource for end-customers and all actors involved in the entire supply chain.

In Italy, rifampicin-resistant and MDR-TB were high in foreign-born persons, but decreased from 2009 to 2016

In the SW Alps, at the NE margin of the Argentera Massif, the occurrence of isolated bodies of silicate-bearing marbles (Valdieri Marble), laterally passing to non-metamorphic Mesozoic limestones of the Dauphinois succession, appears enigmatic, since their origin cannot be related to the regional metamorphism. The stratigraphic, geometric, petrographic, and geochemical features of the Valdieri Marble indicate that it originated from the upflow of hydrothermal fluids which deeply recrystallised the limestone and provoked the abundant neoblastesis of silicate minerals, at an estimated crystallisation temperature of ca. 350 °C. This paper provides for the first time an absolute U/Pb age, comprised between 30 and 31.6 Ma (early Oligocene), for the Valdieri Marble, which is affected by a syn-genetic shear foliation in turn crosscut by the main Alpine tectonic foliations. The hydrothermal fluids that formed the Valdieri Marble migrated along low-angle shear zones, mostly parallel to the sedimentary primary bedding, which were downward connected with high-angle master faults of the “Alpine SW transfer”, a main Oligocene–early Miocene transcurrent shear zone at the southern termination of the Western Alps. The localized heat flow sustaining the hydrothermal system could be related to the early Oligocene thermal event, well documented by magmatic activity in the Western and Central Alps.

The environment of manufacturing and assembly manual activities radically evolved in the last decades. First, the western world workforce is alarmingly aging. In the last 15 years the percentage of European employees older than 50 years rose from 21.6% to 30.4%. Furthermore, the latest developments in legislations (EU Machinery directive, 2006/42/EC, 89/391/EEC, Occupational Safety and Health act) force the companies to assess, monitor and safeguard the health of their operators. Finally, an increasing pressure from the civil society and the stakeholders pretends safe working conditions in manufacturing and assembly processes. This paper tackles these issues proposing an original Motion Analysis System (MAS) for the ergonomic assessment of human operators involved in industrial processes. This research exploits different motion capture (MOCAP) technologies, e.g. optical, inertial and miscellaneous, to register the static postures and the dynamic movements of an operator during manufacturing or assembly activities. The information provided by the MOCAP technologies about the evolution over time of the position and orientation of the skeleton segments are processed by the MAS. This system calculates for each monitored frame the angle values of all the relevant joints of the human body accurately reproducing the operator movements. Furthermore, the MAS assesses the risk of musculoskeletal disorders of the performed manufacturing and assembly activities with the automatic evaluation of three ergonomic indices considering the features of the products and tools which the operator pick and handle. Along with the calculation of REBA and OWAS indices, an original one is developed and proposed based on the ISO 11226:2000 norm. The MAS is tested and validated with the industrial case study of a gearbox assembly process comparing the novel ergonomic index with the traditional ones. The results suggest that the proposed index accurately evaluates the ergonomic risk of specific assembly tasks compared to the classical approaches.

Pure water is the key resource of the Earth's life. Its availability is as important as critic especially in the developing regions, within areas stricken by natural catastrophes or wars and in humanitarian camps. The lack of drinkable water makes daily life almost impossible, forcing people to make strong efforts to survive. Furthermore, during the last decades, humanitarian organizations invested funds to improve solutions to strike the lack of drinkable water in overpopulated areas. Different improvements made in the last decades on water desalination, the most critical water filtration. These plants should be the answer also in humanitarian sector and in developing regions to tackle the problem of scarcity of drinkable water. Nowadays several desalination technologies and plants are available: however, due to them characteristics, nonporous membranes for the raw-water desalination and purification could be the most feasible solution for this difficult field. Reverse osmosis (RO) or Forward Osmosis (FO) plants allow producing ultra-pure drinkable water from water resources caught in nature, e.g. sea, rivers, lakes and aquifers. This paper starts from a critical review of the topic and of the most promising technologies for water purification. After that, it proposes a mix of guidelines and best design practices targeted on nonporous membrane technologies to produce ultra-pure drinkable water targeted on rural, i.e. severe, environments. The final long-Term goal is to support humanitarian logistics operating in critical contexts.

The Provençal and Dauphinois Mesozoic successions cropping out at the southeastern margin of the Argentera Massif (Maritime Alps, NW Italy) were deposited at the transition between the Provençal platform and the Dauphinois basin, marked in the study area by a partly preserved Mesozoic palaeoescarpment. These successions show important lateral variations occurring over relatively short distances, probably related to syndepositional tectonics. Different stratigraphic intervals of the pelagic-hemipelagic Dauphinois succession contain resedimented deposits, made up of both intra- and extrabasinal material, which provide a twofold evidence of syndepositional tectonics indicating both tectonically-triggered gravitational processes and a tectonically-driven evolution of the source areas. Two stages of syndepositional tectonics have been recognized: the first in the earliest Cretaceous, which is related to the deposition of carbonate breccias in the Dauphinois succession and to hydrothermal dolomitization of the Middle Triassic-Jurassic Provençal carbonates, and the second in the Late Cretaceous, which triggered the deposition of different detrital lithozones in the Upper Cretaceous Puriac Limestone. The cited evidence indicates that syndepositional tectonics continued to influence the evolution of the Alpine Tethys European passive margin long after the Late Triassic-Early Jurassic syn-rift stage, which caused the differentiation between the Dauphinois basin and the Provençal platform., Rivista Italiana di Paleontologia e Stratigrafia (Research In Paleontology and Stratigraphy), V. 123, N. 3 (2017)

The geologic mapping process requires the organization of data according to the general knowledge about the objects in the map, namely the geologic units, and to the objectives of a graphic representation of such objects in a map, following some established model of geotectonic evolution. Semantics can greatly help such a process in providing a terminological base to name and classify the objects of the map and supporting the application of reasoning mechanisms for the derivation of novel properties and relations about the objects of the map. The OntoGeonous initiative has built a terminological base of geological knowledge in a machine-readable format, following the Semantic Web tenets and the Linked Data paradigm, with the construction of an appropriate data base schema that can be then filled with the objects of the map. The paper will present the conceptual model of the geologic system and how the elements of the cartographic database are classified from general definitions. Also, the paper addresses the setup of web-based services that respond to queries concerning the properties of the map elements that are not explicitly asserted in the underlying data base, but are inferred through a reasoning process.

No information is currently available on the influence of injectable second-line drugs on treatment outcomes of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) patients. To investigate this issue, a large series of MDR- and XDR-TB cases diagnosed in Estonia, Germany, Italy and the Russian Federation (Archangels Oblast) between 1999 and 2006 were analysed. All study sites performed drug susceptibility testing for first- and second-line anti-TB drugs, laboratory quality assurance and treatment delivery according to World Health Organization recommendations. Out of 4,583 culture-confirmed cases, 240 MDR- and 48 XDR-TB cases had a definitive outcome recorded (treatment success, death, failure). Among MDR- and XDR-TB cases, capreomycin resistance yielded a higher proportion of failure and death than capreomycin-susceptible cases. Resistance to capreomycin was independently associated with unfavourable outcome (logistic regression analysis: odds ratio 3.51). In the treatment of patients with multidrug-resistant and extensively drug-resistant tuberculosis, resistance to the injectable drug capreomycin was an independent predictor for therapy failure in this cohort. As Mycobacterium tuberculosis drug resistance is increasing worldwide, there is an urgent need for novel interventions in the fight against tuberculosis.

In many urban and natural areas, the presence of naturally occurring asbestos (NOA) requires a geological risk evaluation to enforce safety and exposure monitoring during the achievement of surface and subsurface infrastructures. A set up of proper procedures must provide: (i) a detailed geological model of the possible presence of the asbestos, (ii) a representative sampling, (iii) a correct analytical approach, and (iv) a working procedure that can be efficiently applied during excavation activities. At present, the EU regulations for a safety work in asbestos-bearing materials are still not exhaustive because of the great complexity of the matter and uncertainties in geological risk definition. This paper presents two case studies where the different involved parties (scientific community, environmental agencies, and private companies) jointly contributed to find technical solutions for a correct risk management of excavations in asbestos-bearing rocks as well as reliable analytical procedures for quantitative determination of the fibre content.