Search

Your search keyword '"Piaggio, Giorgio"' showing total 38 results
Start Over Author "Piaggio, Giorgio"
38 results on '"Piaggio, Giorgio"'

3. Mouse and human studies support DSTYK loss of function as a low-penetrance and variable expressivity risk factor for congenital urinary tract anomalies

Author

Martino, Jeremiah, Liu, Qingxue, Vukojevic, Katarina, Ke, Juntao, Lim, Tze Y., Khan, Atlas, Gupta, Yask, Perez, Alejandra, Yan, Zonghai, Milo Rasouly, Hila, Vena, Natalie, Lippa, Natalie, Giordano, Jessica L., Saraga, Marijan, Saraga-Babic, Mirna, Westland, Rik, Bodria, Monica, Piaggio, Giorgio, Bendapudi, Pavan K., Iglesias, Alejandro D., Wapner, Ronald J., Tasic, Velibor, Wang, Fan, Ionita-Laza, Iuliana, Ghiggeri, Gian Marco, Kiryluk, Krzysztof, Sampogna, Rosemary V., Mendelsohn, Cathy L., D’Agati, Vivette D., Gharavi, Ali G., and Sanna-Cherchi, Simone

Published
2023
Full Text
View/download PDF

4. The copy number variation landscape of congenital anomalies of the kidney and urinary tract.

Author

Verbitsky, Miguel, Westland, Rik, Perez, Alejandra, Kiryluk, Krzysztof, Liu, Qingxue, Krithivasan, Priya, Mitrotti, Adele, Fasel, David, Batourina, Ekaterina, Sampson, Matthew, Bodria, Monica, Werth, Max, Kao, Charlly, Martino, Jeremiah, Capone, Valentina, Vivante, Asaf, Shril, Shirlee, Kil, Byum, Marasà, Maddalena, Zhang, Jun, Na, Young-Ji, Lim, Tze, Ahram, Dina, Weng, Patricia, Heinzen, Erin, Carrea, Alba, Piaggio, Giorgio, Gesualdo, Loreto, Manca, Valeria, Masnata, Giuseppe, Gigante, Maddalena, Cusi, Daniele, Izzi, Claudia, Scolari, Francesco, van Wijk, Joanna, Saraga, Marijan, Santoro, Domenico, Conti, Giovanni, Zamboli, Pasquale, White, Hope, Drozdz, Dorota, Zachwieja, Katarzyna, Miklaszewska, Monika, Tkaczyk, Marcin, Tomczyk, Daria, Krakowska, Anna, Sikora, Przemyslaw, Jarmoliński, Tomasz, Borszewska-Kornacka, Maria, Pawluch, Robert, Szczepanska, Maria, Adamczyk, Piotr, Mizerska-Wasiak, Malgorzata, Krzemien, Grazyna, Szmigielska, Agnieszka, Zaniew, Marcin, Dobson, Mark, Darlow, John, Puri, Prem, Barton, David, Furth, Susan, Warady, Bradley, Gucev, Zoran, Lozanovski, Vladimir, Tasic, Velibor, Pisani, Isabella, Allegri, Landino, Rodas, Lida, Campistol, Josep, Jeanpierre, Cécile, Alam, Shumyle, Casale, Pasquale, Wong, Craig, Lin, Fangming, Miranda, Débora, Oliveira, Eduardo, Simões-E-Silva, Ana, Barasch, Jonathan, Levy, Brynn, Wu, Nan, Hildebrandt, Friedhelm, Ghiggeri, Gian, Latos-Bielenska, Anna, Materna-Kiryluk, Anna, Zhang, Feng, Hakonarson, Hakon, Papaioannou, Virginia, Mendelsohn, Cathy, Gharavi, Ali, and Sanna-Cherchi, Simone

Subjects
Chromosome Deletion, DNA Copy Number Variations, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney, Male, Urinary Tract, Urogenital Abnormalities, Vesico-Ureteral Reflux
Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) are a major cause of pediatric kidney failure. We performed a genome-wide analysis of copy number variants (CNVs) in 2,824 cases and 21,498 controls. Affected individuals carried a significant burden of rare exonic (that is, affecting coding regions) CNVs and were enriched for known genomic disorders (GD). Kidney anomaly (KA) cases were most enriched for exonic CNVs, encompassing GD-CNVs and novel deletions; obstructive uropathy (OU) had a lower CNV burden and an intermediate prevalence of GD-CNVs; and vesicoureteral reflux (VUR) had the fewest GD-CNVs but was enriched for novel exonic CNVs, particularly duplications. Six loci (1q21, 4p16.1-p16.3, 16p11.2, 16p13.11, 17q12 and 22q11.2) accounted for 65% of patients with GD-CNVs. Deletions at 17q12, 4p16.1-p16.3 and 22q11.2 were specific for KA; the 16p11.2 locus showed extensive pleiotropy. Using a multidisciplinary approach, we identified TBX6 as a driver for the CAKUT subphenotypes in the 16p11.2 microdeletion syndrome.

Published
2019

5. Rituximab for very low dose steroid-dependent nephrotic syndrome in children: a randomized controlled study

Author

Ravani, Pietro, Lugani, Francesca, Pisani, Isabella, Bodria, Monica, Piaggio, Giorgio, Bartolomeo, Domenico, and Prunotto, Marco

Subjects
Steroids (Drugs) -- Comparative analysis -- Usage, Nephrotic syndrome -- Drug therapy, Pediatric research -- Comparative analysis -- Usage, Health
Abstract

Background Steroid-dependent nephrotic syndrome (SDNS) carries a high risk of toxicity from steroids or steroid-sparing agents. This open-label, randomized controlled trial was designed to test whether the monoclonal antibody rituximab is non-inferior to steroids in maintaining remission in juvenile forms of SDNS and how long remission may last (EudraCT:2008-004486-26). Methods We enrolled 30 children 4-15 years who had developed SDNS 6-12 months before and were maintained in remission with low prednisone doses (0.1-0.4 mg/Kg/day). Participants were randomized following a non-inferiority design to continue prednisone alone (n 15, controls) or to add a single intravenous infusion of rituximab (375 mg/m.sup.2, n 15 intervention). Prednisone was tapered in both arms after 1 month. Children assigned to the control arm were allowed to receive rituximab to treat disease relapse. Results Proteinuria increased at 3 months in the prednisone group (from 0.14 to 1.5 g/day) (p < 0.001) and remained unchanged in the rituximab group (0.14 g/day). Fourteen children in the control arm relapsed within 6 months. Thirteen children assigned to rituximab (87%) were still in remission at 1 year and 8 (53%) at 4 years. Responses were similar in children of the control group who received rituximab to treat disease relapse. We did not record significant adverse events. Conclusions Rituximab was non-inferior to steroids for the treatment of juvenile SDNS. One in two children remains in remission at 4 years following a single infusion of rituximab, without significant adverse events. Further studies are needed to clarify the superiority of rituximab over low-dose corticosteroid as a treatment of SDNS., Author(s): Pietro Ravani [sup.1] , Francesca Lugani [sup.2] , Isabella Pisani [sup.3] , Monica Bodria [sup.2] , Giorgio Piaggio [sup.2] , Domenico Bartolomeo [sup.3] , Marco Prunotto [sup.4] , Gian [...]

Published
2020
Full Text
View/download PDF

8. Mutations in DSTYK and Dominant Urinary Tract Malformations

Author

Sanna-Cherchi, Simone, Sampogna, Rosemary V, Papeta, Natalia, Burgess, Katelyn E, Nees, Shannon N, Perry, Brittany J, Choi, Murim, Bodria, Monica, Liu, Yan, Weng, Patricia L, Lozanovski, Vladimir J, Verbitsky, Miguel, Lugani, Francesca, Sterken, Roel, Paragas, Neal, Caridi, Gianluca, Carrea, Alba, Dagnino, Monica, Materna-Kiryluk, Anna, Santamaria, Giuseppe, Murtas, Corrado, Ristoska-Bojkovska, Nadica, Izzi, Claudia, Kacak, Nilgun, Bianco, Beatrice, Giberti, Stefania, Gigante, Maddalena, Piaggio, Giorgio, Gesualdo, Loreto, Vukic, Durdica Kosuljandic, Vukojevic, Katarina, Saraga-Babic, Mirna, Saraga, Marijan, Gucev, Zoran, Allegri, Landino, Latos-Bielenska, Anna, Casu, Domenica, State, Matthew, Scolari, Francesco, Ravazzolo, Roberto, Kiryluk, Krzysztof, Al-Awqati, Qais, D'Agati, Vivette D, Drummond, Iain A, Tasic, Velibor, Lifton, Richard P, Ghiggeri, Gian Marco, and Gharavi, Ali G

Subjects
Urologic Diseases, Pediatric, Congenital Structural Anomalies, Human Genome, Kidney Disease, Biotechnology, Genetics, Clinical Research, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Underpinning research, Aetiology, Renal and urogenital, Adult, Animals, Base Sequence, Child, Exome, Female, Gene Knockdown Techniques, Genetic Linkage, Genome-Wide Association Study, Heterozygote, Humans, Infant, Kidney, Male, Mice, Molecular Sequence Data, Mutation, Pedigree, RNA, Small Interfering, Receptor-Interacting Protein Serine-Threonine Kinases, Urinary Tract, Urogenital Abnormalities, Young Adult, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundCongenital abnormalities of the kidney and the urinary tract are the most common cause of pediatric kidney failure. These disorders are highly heterogeneous, and the etiologic factors are poorly understood.MethodsWe performed genomewide linkage analysis and whole-exome sequencing in a family with an autosomal dominant form of congenital abnormalities of the kidney or urinary tract (seven affected family members). We also performed a sequence analysis in 311 unrelated patients, as well as histologic and functional studies.ResultsLinkage analysis identified five regions of the genome that were shared among all affected family members. Exome sequencing identified a single, rare, deleterious variant within these linkage intervals, a heterozygous splice-site mutation in the dual serine-threonine and tyrosine protein kinase gene (DSTYK). This variant, which resulted in aberrant splicing of messenger RNA, was present in all affected family members. Additional, independent DSTYK mutations, including nonsense and splice-site mutations, were detected in 7 of 311 unrelated patients. DSTYK is highly expressed in the maturing epithelia of all major organs, localizing to cell membranes. Knockdown in zebrafish resulted in developmental defects in multiple organs, which suggested loss of fibroblast growth factor (FGF) signaling. Consistent with this finding is the observation that DSTYK colocalizes with FGF receptors in the ureteric bud and metanephric mesenchyme. DSTYK knockdown in human embryonic kidney cells inhibited FGF-stimulated phosphorylation of extracellular-signal-regulated kinase (ERK), the principal signal downstream of receptor tyrosine kinases.ConclusionsWe detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling. (Funded by the National Institutes of Health and others.).

Published
2013

10. Functional Magnetic Resonance Urography in Ureteropelvic Junction Obstruction: Proposal for a Pediatric Quantitative Score

Author

Damasio, Maria Beatrice, primary, Sertorio, Fiammetta, additional, Wong, Michela Cing Yu, additional, Campo, Irene, additional, Carlucci, Marcello, additional, Basso, Luca, additional, Anfigeno, Lorenzo, additional, Bodria, Monica, additional, Pistorio, Angela, additional, Piaggio, Giorgio, additional, Ghiggeri, Gian Marco, additional, and Mattioli, Girolamo, additional

Published
2022
Full Text
View/download PDF

11. Epidemiology of Antibiotic Resistant Pathogens in Pediatric Urinary Tract Infections as a Tool to Develop a Prediction Model for Early Detection of Drug-Specific Resistance

Author

Bagnasco, Francesca, primary, Piaggio, Giorgio, additional, Mesini, Alessio, additional, Mariani, Marcello, additional, Russo, Chiara, additional, Saffioti, Carolina, additional, Losurdo, Giuseppe, additional, Palmero, Candida, additional, and Castagnola, Elio, additional

Published
2022
Full Text
View/download PDF

13. Author Correction: The copy number variation landscape of congenital anomalies of the kidney and urinary tract

Author

Verbitsky, Miguel, Westland, Rik, Perez, Alejandra, Kiryluk, Krzysztof, Liu, Qingxue, Krithivasan, Priya, Mitrotti, Adele, Fasel, David A., Batourina, Ekaterina, Sampson, Matthew G., Bodria, Monica, Werth, Max, Kao, Charlly, Martino, Jeremiah, Capone, Valentina P., Vivante, Asaf, Shril, Shirlee, Kil, Byum Hee, Marasa, Maddalena, Zhang, Jun Y., Na, Young-Ji, Lim, Tze Y., Ahram, Dina, Weng, Patricia L., Heinzen, Erin L., Carrea, Alba, Piaggio, Giorgio, Gesualdo, Loreto, Manca, Valeria, Masnata, Giuseppe, Gigante, Maddalena, Cusi, Daniele, Izzi, Claudia, Scolari, Francesco, van Wijk, Joanna A. E., Saraga, Marijan, Santoro, Domenico, Conti, Giovanni, Zamboli, Pasquale, White, Hope, Drozdz, Dorota, Zachwieja, Katarzyna, Miklaszewska, Monika, Tkaczyk, Marcin, Tomczyk, Daria, Krakowska, Anna, Sikora, Przemyslaw, Jarmoliński, Tomasz, Borszewska-Kornacka, Maria K., Pawluch, Robert, Szczepanska, Maria, Adamczyk, Piotr, Mizerska-Wasiak, Malgorzata, Krzemien, Grazyna, Szmigielska, Agnieszka, Zaniew, Marcin, Dobson, Mark G., Darlow, John M., Puri, Prem, Barton, David E., Furth, Susan L., Warady, Bradley A., Gucev, Zoran, Lozanovski, Vladimir J., Tasic, Velibor, Pisani, Isabella, Allegri, Landino, Rodas, Lida M., Campistol, Josep M., Jeanpierre, Cécile, Alam, Shumyle, Casale, Pasquale, Wong, Craig S., Lin, Fangming, Miranda, Débora M., Oliveira, Eduardo A., Simoes-e-Silva, Ana Cristina, Barasch, Jonathan M., Levy, Brynn, Wu, Nan, Hildebrandt, Friedhelm, Ghiggeri, Gian Marco, Latos-Bielenska, Anna, Materna-Kiryluk, Anna, Zhang, Feng, Hakonarson, Hakon, Papaioannou, Virginia E., Mendelsohn, Cathy L., Gharavi, Ali G., and Sanna-Cherchi, Simone

Published
2019
Full Text
View/download PDF

14. Surgical validation of functional magnetic resonance urography in the study of ureteral anomalies distal to the uretero-pelvic junction in a pediatric cohort

Author

SERTORIO, Fiammetta, primary, DELFINO, Lorenza, additional, WONG, Michela C.Y., additional, PALO, Federico, additional, CARLUCCI, Marcello, additional, FIORENZA, Venusia, additional, BASSO, Luca, additional, ANFIGENO, Lorenzo, additional, PIAGGIO, Giorgio, additional, DAMASIO, Maria B., additional, and MATTIOLI, Girolamo, additional

Published
2022
Full Text
View/download PDF

17. Supplement to: Mutations in DSTYK and dominant urinary tract malformations.

Author

Sanna-Cherchi, Simone, Sampogna, Rosemary V, Papeta, Natalia, Burgess, Katelyn E, Nees, Shannon N, Perry, Brittany J, Choi, Murim, Bodria, Monica, Liu, Yan, Weng, Patricia L, Lozanovski, Vladimir J, Verbitsky, Miguel, Lugani, Francesca, Sterken, Roel, Paragas, Neal, Caridi, Gianluca, Carrea, Alba, Dagnino, Monica, Materna-Kiryluk, Anna, Santamaria, Giuseppe, Murtas, Corrado, Ristoska-Bojkovska, Nadica, Izzi, Claudia, Kacak, Nilgun, Bianco, Beatrice, Giberti, Stefania, Gigante, Maddalena, Piaggio, Giorgio, Gesualdo, Loreto, Vukic, Durdica Kosuljandic, Vukojevic, Katarina, Saraga-Babic, Mirna, Saraga, Marijan, Gucev, Zoran, Allegri, Landino, Latos-Bielenska, Anna, Casu, Domenica, State, Matthew, Scolari, Francesco, Ravazzolo, Roberto, Kiryluk, Krzysztof, Al-Awqati, Qais, DʼAgati, Vivette, Drummond, Iain A., Tasic, Velibor, Lifton, Richard P, Ghiggeri, Gian Marco, and Gharavi, Ali G

Published
2013

18. Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux

Author

Verbitsky, Miguel, primary, Krithivasan, Priya, additional, Batourina, Ekaterina, additional, Khan, Atlas, additional, Graham, Sarah E., additional, Marasà, Maddalena, additional, Kim, Hyunwoo, additional, Lim, Tze Y., additional, Weng, Patricia L., additional, Sánchez-Rodríguez, Elena, additional, Mitrotti, Adele, additional, Ahram, Dina F., additional, Zanoni, Francesca, additional, Fasel, David A., additional, Westland, Rik, additional, Sampson, Matthew G., additional, Zhang, Jun Y., additional, Bodria, Monica, additional, Kil, Byum Hee, additional, Shril, Shirlee, additional, Gesualdo, Loreto, additional, Torri, Fabio, additional, Scolari, Francesco, additional, Izzi, Claudia, additional, van Wijk, Joanna A.E., additional, Saraga, Marijan, additional, Santoro, Domenico, additional, Conti, Giovanni, additional, Barton, David E., additional, Dobson, Mark G., additional, Puri, Prem, additional, Furth, Susan L., additional, Warady, Bradley A., additional, Pisani, Isabella, additional, Fiaccadori, Enrico, additional, Allegri, Landino, additional, Degl'Innocenti, Maria Ludovica, additional, Piaggio, Giorgio, additional, Alam, Shumyle, additional, Gigante, Maddalena, additional, Zaza, Gianluigi, additional, Esposito, Pasquale, additional, Lin, Fangming, additional, Simões-e-Silva, Ana Cristina, additional, Brodkiewicz, Andrzej, additional, Drozdz, Dorota, additional, Zachwieja, Katarzyna, additional, Miklaszewska, Monika, additional, Szczepanska, Maria, additional, Adamczyk, Piotr, additional, Tkaczyk, Marcin, additional, Tomczyk, Daria, additional, Sikora, Przemyslaw, additional, Mizerska-Wasiak, Malgorzata, additional, Krzemien, Grazyna, additional, Szmigielska, Agnieszka, additional, Zaniew, Marcin, additional, Lozanovski, Vladimir J., additional, Gucev, Zoran, additional, Ionita-Laza, Iuliana, additional, Stanaway, Ian B., additional, Crosslin, David R., additional, Wong, Craig S., additional, Hildebrandt, Friedhelm, additional, Barasch, Jonathan, additional, Kenny, Eimear E., additional, Loos, Ruth J.F., additional, Levy, Brynn, additional, Ghiggeri, Gian Marco, additional, Hakonarson, Hakon, additional, Latos-Bieleńska, Anna, additional, Materna-Kiryluk, Anna, additional, Darlow, John M., additional, Tasic, Velibor, additional, Willer, Cristen, additional, Kiryluk, Krzysztof, additional, Sanna-Cherchi, Simone, additional, Mendelsohn, Cathy L., additional, and Gharavi, Ali G., additional

Published
2021
Full Text
View/download PDF

21. Glomerulocystic kidney disease in a family

Author

Gusmano, Rosanna, Caridi, Gianluca, Marini, Monica, Perfumo, Francesco, Ghiggeri, Gian Marco, Piaggio, Giorgio, Ceccherini, Isabella, and Seri, Marco

Published
2002

23. The copy number variation landscape of congenital anomalies of the kidney and urinary tract

Author

Verbitsky, Miguel, primary, Westland, Rik, additional, Perez, Alejandra, additional, Kiryluk, Krzysztof, additional, Liu, Qingxue, additional, Krithivasan, Priya, additional, Mitrotti, Adele, additional, Fasel, David A., additional, Batourina, Ekaterina, additional, Sampson, Matthew G., additional, Bodria, Monica, additional, Werth, Max, additional, Kao, Charlly, additional, Martino, Jeremiah, additional, Capone, Valentina P., additional, Vivante, Asaf, additional, Shril, Shirlee, additional, Kil, Byum Hee, additional, Marasà, Maddalena, additional, Zhang, Jun Y., additional, Na, Young-Ji, additional, Lim, Tze Y., additional, Ahram, Dina, additional, Weng, Patricia L., additional, Heinzen, Erin L., additional, Carrea, Alba, additional, Piaggio, Giorgio, additional, Gesualdo, Loreto, additional, Manca, Valeria, additional, Masnata, Giuseppe, additional, Gigante, Maddalena, additional, Cusi, Daniele, additional, Izzi, Claudia, additional, Scolari, Francesco, additional, van Wijk, Joanna A. E., additional, Saraga, Marijan, additional, Santoro, Domenico, additional, Conti, Giovanni, additional, Zamboli, Pasquale, additional, White, Hope, additional, Drozdz, Dorota, additional, Zachwieja, Katarzyna, additional, Miklaszewska, Monika, additional, Tkaczyk, Marcin, additional, Tomczyk, Daria, additional, Krakowska, Anna, additional, Sikora, Przemyslaw, additional, Jarmoliński, Tomasz, additional, Borszewska-Kornacka, Maria K., additional, Pawluch, Robert, additional, Szczepanska, Maria, additional, Adamczyk, Piotr, additional, Mizerska-Wasiak, Malgorzata, additional, Krzemien, Grazyna, additional, Szmigielska, Agnieszka, additional, Zaniew, Marcin, additional, Dobson, Mark G., additional, Darlow, John M., additional, Puri, Prem, additional, Barton, David E., additional, Furth, Susan L., additional, Warady, Bradley A., additional, Gucev, Zoran, additional, Lozanovski, Vladimir J., additional, Tasic, Velibor, additional, Pisani, Isabella, additional, Allegri, Landino, additional, Rodas, Lida M., additional, Campistol, Josep M., additional, Jeanpierre, Cécile, additional, Alam, Shumyle, additional, Casale, Pasquale, additional, Wong, Craig S., additional, Lin, Fangming, additional, Miranda, Débora M., additional, Oliveira, Eduardo A., additional, Simões-e-Silva, Ana Cristina, additional, Barasch, Jonathan M., additional, Levy, Brynn, additional, Wu, Nan, additional, Hildebrandt, Friedhelm, additional, Ghiggeri, Gian Marco, additional, Latos-Bielenska, Anna, additional, Materna-Kiryluk, Anna, additional, Zhang, Feng, additional, Hakonarson, Hakon, additional, Papaioannou, Virginia E., additional, Mendelsohn, Cathy L., additional, Gharavi, Ali G., additional, and Sanna-Cherchi, Simone, additional

Published
2018
Full Text
View/download PDF

26. Adverse events linked with the use of chimeric and humanized anti-CD20 antibodies in children with idiopathic nephrotic syndrome

Author

Bonanni, Alice, primary, Calatroni, Marta, additional, D'Alessandro, Matteo, additional, Signa, Sara, additional, Bertelli, Enrica, additional, Cioni, Michela, additional, Di Marco, Eddi, additional, Biassoni, Roberto, additional, Caridi, Gianluca, additional, Ingrasciotta, Giulia, additional, Bertelli, Roberta, additional, Di Donato, Armando, additional, Bruschi, Maurizio, additional, Canepa, Alberto, additional, Piaggio, Giorgio, additional, Ravani, Pietro, additional, and Ghiggeri, Gian Marco, additional

Published
2018
Full Text
View/download PDF

28. Mouse and human studies support DSTYKloss of function as a low-penetrance and variable expressivity risk factor for congenital urinary tract anomalies

Author

Martino, Jeremiah, Liu, Qingxue, Vukojevic, Katarina, Ke, Juntao, Lim, Tze Y., Khan, Atlas, Gupta, Yask, Perez, Alejandra, Yan, Zonghai, Milo Rasouly, Hila, Vena, Natalie, Lippa, Natalie, Giordano, Jessica L., Saraga, Marijan, Saraga-Babic, Mirna, Westland, Rik, Bodria, Monica, Piaggio, Giorgio, Bendapudi, Pavan K., Iglesias, Alejandro D., Wapner, Ronald J., Tasic, Velibor, Wang, Fan, Ionita-Laza, Iuliana, Ghiggeri, Gian Marco, Kiryluk, Krzysztof, Sampogna, Rosemary V., Mendelsohn, Cathy L., D’Agati, Vivette D., Gharavi, Ali G., and Sanna-Cherchi, Simone

Abstract

Previous work identified rare variants in DSTYKassociated with human congenital anomalies of the kidney and urinary tract (CAKUT). Here, we present a series of mouse and human studies to clarify the association, penetrance, and expressivity of DSTYKvariants.

Published
2023
Full Text
View/download PDF

29. Candida infections in paediatrics: Results from a prospective single‐centre study in a tertiary care children's hospital

Author

Mesini, Alessio, primary, Bandettini, Roberto, additional, Caviglia, Ilaria, additional, Fioredda, Francesca, additional, Amoroso, Loredana, additional, Faraci, Maura, additional, Mattioli, Girolamo, additional, Piaggio, Giorgio, additional, Risso, Francesco M., additional, Moscatelli, Andrea, additional, Loy, Anna, additional, and Castagnola, Elio, additional

Published
2016
Full Text
View/download PDF

30. Glomerular Autoimmune Multicomponents of Human Lupus Nephritis In Vivo (2)

Author

Bruschi, Maurizio, primary, Galetti, Maricla, additional, Sinico, Renato Alberto, additional, Moroni, Gabriella, additional, Bonanni, Alice, additional, Radice, Antonella, additional, Tincani, Angela, additional, Pratesi, Federico, additional, Migliorini, Paola, additional, Murtas, Corrado, additional, Franceschini, Franco, additional, Trezzi, Barbara, additional, Brunini, Francesca, additional, Gatti, Rita, additional, Tardanico, Regina, additional, Barbano, Giancarlo, additional, Piaggio, Giorgio, additional, Messa, Piergiorgio, additional, Ravani, Pietro, additional, Scolari, Francesco, additional, Candiano, Giovanni, additional, Martini, Alberto, additional, Allegri, Landino, additional, and Ghiggeri, Gian Marco, additional

Published
2015
Full Text
View/download PDF

31. Invasive mould infections in newborns and children

Author

Castagnola, Elio, primary, Faraci, Maura, additional, Fioredda, Francesca, additional, Amoroso, Loredana, additional, Risso, Francesco, additional, Franceschi, Alessia, additional, Bandettini, Roberto, additional, Magnano, Gian Michele, additional, Prato, Alessio Pini, additional, Gardella, Chiara, additional, Arrigo, Serena, additional, Gattorno, Marco, additional, Piaggio, Giorgio, additional, Ciucci, Antonella, additional, Lorenzi, Ines, additional, Loy, Anna, additional, and Haupt, Riccardo, additional

Published
2011
Full Text
View/download PDF

32. Renal outcome in patients with congenital anomalies of the kidney and urinary tract

Author

Sanna-Cherchi, Simone, primary, Ravani, Pietro, additional, Corbani, Valentina, additional, Parodi, Stefano, additional, Haupt, Riccardo, additional, Piaggio, Giorgio, additional, Innocenti, Maria L Degli, additional, Somenzi, Danio, additional, Trivelli, Antonella, additional, Caridi, Gianluca, additional, Izzi, Claudia, additional, Scolari, Francesco, additional, Mattioli, Girolamo, additional, Allegri, Landino, additional, and Ghiggeri, Gian Marco, additional

Published
2009
Full Text
View/download PDF

38. Gram-negative urinary tract infections and increasing isolation of ESBL-producing or ceftazidime-resistant strains in children: results from a single-centre survey.

Author

Giardino S, Bandettini R, Perotti M, Piaggio G, Degl'Innocenti L, Sacco R, Ciucci A, Caviglia I, Barabino P, Ginocchio F, Losurdo G, Haupt R, and Castagnola E

Subjects
Anti-Bacterial Agents therapeutic use, Ceftazidime therapeutic use, Child, Child, Preschool, Drug Resistance, Multiple, Bacterial, Escherichia coli enzymology, Escherichia coli metabolism, Escherichia coli Infections drug therapy, Gram-Negative Bacteria drug effects, Gram-Negative Bacterial Infections epidemiology, Health Surveys, Hospitals, Pediatric, Hospitals, University, Humans, Incidence, Italy epidemiology, Microbial Sensitivity Tests, Prospective Studies, Risk Factors, Urinary Tract Infections epidemiology, Anti-Bacterial Agents pharmacology, Ceftazidime pharmacology, Gram-Negative Bacteria isolation & purification, Gram-Negative Bacterial Infections drug therapy, Urinary Tract Infections drug therapy, Urinary Tract Infections microbiology, beta-Lactamases biosynthesis
Abstract

Urinary tract infections (UTIs) are an important cause of morbidity in paediatrics, especially related to urinary tract malformation and neurogenic bladder dysfunction. The infection control team of Istituto Giannina Gaslini, Genova, Italy, performs a prospective survey on the epidemiology of UTI in children admitted in the hospital, and data are expressed as episodes/1000 days of hospital admission. From 2007 to 2011 there was an increase in the rate of Gram-negative UTIs, especially in the Nephrology Unit (from 11.63 to 27.48, r-coefficient 0.95, P minor 0.05), associated with an increase in infections due to ESBL-producing strains (from 0.54 to 2.55, r-coefficient 0.89, P 0.05). This study indicates that there is an increase in the rate of Gram-negative UTIs, also due to resistant strains. The cause may be multifactorial, but it is noteworthy that it has been mainly observed in a ward where low-dose, long-term administration of antibacterial prophylaxis in children with urinary malformations or neurogenic bladder dysfunction is routine. This phenomenon gives cause for concern and should be monitored carefully to avoid the risk of selecting resistant bacteria that have no therapeutic options.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results