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12 results on '"Phimmachanh, Monica"'

1. Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism

Author

Filipe, Elysse C., primary, Velayuthar, Sipiththa, additional, Philp, Ashleigh, additional, Nobis, Max, additional, Latham, Sharissa L., additional, Parker, Amelia L., additional, Murphy, Kendelle J., additional, Wyllie, Kaitlin, additional, Major, Gretel S., additional, Contreras, Osvaldo, additional, Mok, Ellie T. Y., additional, Enriquez, Ronaldo F., additional, McGowan, Suzanne, additional, Feher, Kristen, additional, Quek, Lake‐Ee, additional, Hancock, Sarah E., additional, Yam, Michelle, additional, Tran, Emmi, additional, Setargew, Yordanos F. I., additional, Skhinas, Joanna N., additional, Chitty, Jessica L., additional, Phimmachanh, Monica, additional, Han, Jeremy Z. R., additional, Cadell, Antonia L., additional, Papanicolaou, Michael, additional, Mahmodi, Hadi, additional, Kiedik, Beata, additional, Junankar, Simon, additional, Ross, Samuel E., additional, Lam, Natasha, additional, Coulson, Rhiannon, additional, Yang, Jessica, additional, Zaratzian, Anaiis, additional, Da Silva, Andrew M., additional, Tayao, Michael, additional, Chin, Ian L., additional, Cazet, Aurélie, additional, Kansara, Maya, additional, Segara, Davendra, additional, Parker, Andrew, additional, Hoy, Andrew J., additional, Harvey, Richard P., additional, Bogdanovic, Ozren, additional, Timpson, Paul, additional, Croucher, David R., additional, Lim, Elgene, additional, Swarbrick, Alexander, additional, Holst, Jeff, additional, Turner, Nigel, additional, Choi, Yu Suk, additional, Kabakova, Irina V., additional, Philp, Andrew, additional, and Cox, Thomas R., additional

Published
2024
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2. YB‐1 regulates mesothelioma cell migration via snail but not EGFR, MMP1, EPHA5 or PARK2.

Author

Schelch, Karin, Eder, Sebastian, Zitta, Benjamin, Phimmachanh, Monica, Johnson, Thomas G., Emminger, Dominik, Wenninger‐Weinzierl, Andrea, Sturtzel, Caterina, Poplimont, Hugo, Ries, Alexander, Hoetzenecker, Konrad, Hoda, Mir A., Berger, Walter, Distel, Martin, Dome, Balazs, Reid, Glen, and Grusch, Michael

Abstract

Pleural mesothelioma (PM) is characterized by rapid growth, local invasion, and limited therapeutic options. The multifunctional oncoprotein Y‐box‐binding protein‐1 (YB‐1) is frequently overexpressed in cancer and its inhibition reduces aggressive behavior in multiple tumor types. Here, we investigated the effects of YB‐1 on target gene regulation and PM cell behavior. Whereas siRNA‐mediated YB‐1 knockdown reduced cell motility, YB‐1 overexpression resulted in scattering, increased migration, and intravasation in vitro. Furthermore, YB‐1 stimulated PM cell spreading in zebrafish. Combined knockdown and inducible overexpression of YB‐1 allowed bidirectional control and rescue of cell migration, the pattern of which was closely followed by the mRNA and protein levels of EGFR and the protein level of snail, whereas the mRNA levels of MMP1, EPHA5, and PARK2 showed partial regulation by YB‐1. Finally, we identified snail as a critical regulator of YB‐1‐mediated cell motility in PM. This study provides insights into the mechanism underlying the aggressive nature of PM and highlights the important role of YB‐1 in this cancer. In this context, we found that YB‐1 closely regulates EGFR and snail, and, moreover, that YB‐1‐induced cell migration depends on snail. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma

Author

Hastings, Jordan F., primary, Latham, Sharissa L., additional, Kamili, Alvin, additional, Wheatley, Madeleine S., additional, Han, Jeremy Z. R., additional, Wong-Erasmus, Marie, additional, Phimmachanh, Monica, additional, Nobis, Max, additional, Pantarelli, Chiara, additional, Cadell, Antonia L., additional, O’Donnell, Yolande E. I., additional, Leong, King Ho, additional, Lynn, Sophie, additional, Geng, Fan-Suo, additional, Cui, Lujing, additional, Yan, Sabrina, additional, Achinger-Kawecka, Joanna, additional, Stirzaker, Clare, additional, Norris, Murray D., additional, Haber, Michelle, additional, Trahair, Toby N., additional, Speleman, Frank, additional, De Preter, Katleen, additional, Cowley, Mark J., additional, Bogdanovic, Ozren, additional, Timpson, Paul, additional, Cox, Thomas R., additional, Kolch, Walter, additional, Fletcher, Jamie I., additional, Fey, Dirk, additional, and Croucher, David R., additional

Published
2023
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4. Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging

Author

Floerchinger, Alessia, primary, Murphy, Kendelle J, primary, Latham, Sharissa L., primary, C.Warren, Sean, primary, McCulloch, Andrew T, primary, Kyung Lee, Young, primary, Stoehr, Janett, primary, Mélénec, Pauline, primary, S.Guaman, Cris, primary, Metcalf, Xanthe L, primary, Lee, Victoria, primary, Zaratzian, Anaiis, primary, Da Silva, Andrew, primary, Tayao, Michael, primary, Rolo, Sonia, primary, Phimmachanh, Monica, primary, Sultani, Ghazal, primary, McDonald, Laura, primary, M. Mason, Susan, primary, Ferrari, Nicola, primary, M. Ooms, Lisa, primary, Johnsson, Anna-Karin E, primary, Spence, Heather J, primary, Olson, Michael, primary, Machesky, Laura M., primary, Sansom, Owen J, primary, P. Morton, Jennifer, primary, Mitchell, Christina A., primary, S. Samuel, Michael, primary, Croucher, David R., primary, Welch, Heidi C. E., primary, Blyth, Karen, primary, Caldon, C. Elizabeth, primary, Herrmann, David, primary, I Anderson, Kurt, primary, Timpson, Paul, primary, and Nobis, Max, primary

Published
2023
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5. YB ‐1 regulates mesothelioma cell migration via snail but not EGFR , MMP1 , EPHA5 or PARK2

Author

Schelch, Karin, primary, Eder, Sebastian, additional, Zitta, Benjamin, additional, Phimmachanh, Monica, additional, Johnson, Thomas G., additional, Emminger, Dominik, additional, Wenninger‐Weinzierl, Andrea, additional, Sturtzel, Caterina, additional, Poplimont, Hugo, additional, Ries, Alexander, additional, Hoetzenecker, Konrad, additional, Hoda, Mir A., additional, Berger, Walter, additional, Distel, Martin, additional, Dome, Balazs, additional, Reid, Glen, additional, and Grusch, Michael, additional

Published
2023
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6. Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging

Author

Floerchinger, Alessia, primary, Murphy, Kendelle J., additional, Latham, Sharissa L., additional, Warren, Sean C., additional, McCulloch, Andrew T., additional, Lee, Young-Kyung, additional, Stoehr, Janett, additional, Mélénec, Pauline, additional, Guaman, Cris S., additional, Metcalf, Xanthe L., additional, Lee, Victoria, additional, Zaratzian, Anaiis, additional, Da Silva, Andrew, additional, Tayao, Michael, additional, Rolo, Sonia, additional, Phimmachanh, Monica, additional, Sultani, Ghazal, additional, McDonald, Laura, additional, Mason, Susan M., additional, Ferrari, Nicola, additional, Ooms, Lisa M., additional, Johnsson, Anna-Karin E., additional, Spence, Heather J., additional, Olson, Michael F., additional, Machesky, Laura M., additional, Sansom, Owen J., additional, Morton, Jennifer P., additional, Mitchell, Christina A., additional, Samuel, Michael S., additional, Croucher, David R., additional, Welch, Heidi C.E., additional, Blyth, Karen, additional, Caldon, C. Elizabeth, additional, Herrmann, David, additional, Anderson, Kurt I., additional, Timpson, Paul, additional, and Nobis, Max, additional

Published
2021
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9. Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

Author

Hastings, Jordan F, primary, Gonzalez Rajal, Alvaro, additional, Latham, Sharissa L, additional, Han, Jeremy ZR, additional, McCloy, Rachael A, additional, O'Donnell, Yolande EI, additional, Phimmachanh, Monica, additional, Murphy, Alexander D, additional, Nagrial, Adnan, additional, Daneshvar, Dariush, additional, Chin, Venessa, additional, Watkins, D Neil, additional, Burgess, Andrew, additional, and Croucher, David R, additional

Published
2020
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10. Author response: Analysis of pulsed cisplatin signalling dynamics identifies effectors of resistance in lung adenocarcinoma

Author

Hastings, Jordan F, primary, Gonzalez Rajal, Alvaro, additional, Latham, Sharissa L, additional, Han, Jeremy ZR, additional, McCloy, Rachael A, additional, O'Donnell, Yolande EI, additional, Phimmachanh, Monica, additional, Murphy, Alexander D, additional, Nagrial, Adnan, additional, Daneshvar, Dariush, additional, Chin, Venessa, additional, Watkins, D Neil, additional, Burgess, Andrew, additional, and Croucher, David R, additional

Published
2020
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11. Dynamic analysis of pulsed cisplatin identifies effectors of resistance in lung adenocarcinoma

Author

Hastings, Jordan F., primary, Gonzalez-Rajal, Alvaro, additional, Han, Jeremy Z.R., additional, McCloy, Rachael A., additional, O’Donnell, Yolande E.I., additional, Phimmachanh, Monica, additional, Murphy, Alexander D., additional, Nagrial, Adnan, additional, Daneshvar, Dariush, additional, Chin, Venessa, additional, Watkins, D. Neil, additional, Burgess, Andrew, additional, and Croucher, David R., additional

Published
2019
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