Search

Your search keyword '"Philouze, Pierre"' showing total 173 results
Start Over Author "Philouze, Pierre"
173 results on '"Philouze, Pierre"'

1. Reappraisal of Oncocytic Adenocarcinoma: Unveiling Its Connection to Oncocytic Variants of Salivary Duct Carcinoma and Mucoepidermoid Carcinoma Through ImmunoHisto-Molecular Perspectives

Author

Vial, Lucas, Descotes, Françoise, Lopez, Jonathan, Alsugair, Ziyad, Céruse, Philippe, Philouze, Pierre, Fieux, Maxime, Wassef, Michel, Baglin, Anne-Catherine, Onea, Mihaela, Castain, Claire, Delvenne, Philippe, Fromont-Hankard, Gaelle, Gilles, Hugot, Monnien, Franck, Mauvais, Olivier, Lépine, Charles, Le Gall, Francois, Rousselet, Marie-Christine, Sudaka, Anne, Uro-Coste, Emmanuelle, Casiraghi, Odile, Costes-Martineau, Valérie, and Benzerdjeb, Nazim

Published
2025
Full Text
View/download PDF

4. Natural history of salivary gland secretory carcinoma: A REFCOR study.

Author

Magana, Marie, Vergez, Sebastien, Verillaud, Benjamin, Garrel, Renaud, Evrard, Diane, Mouawad, François, de Gabory, Ludovic, Fakhry, Nicolas, Jegoux, Franck, Malard, Olivier, Bach, Christine, Philouze, Pierre, Aubry, Karine, Mauvais, Olivier, Moya Plana, Antoine, Marie, Jean Paul, Baujat, Bertrand, and Atallah, Sarah

Published
2024
Full Text
View/download PDF

5. Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights

Author

Ala-Eddine, C., Aubry, K., Babin, E., Bach, C., Badoual, C., Baglin, A.C., Barry, B., Bastit, V., Baujat, B., Benezery, K., Bensadoun, R.J., Benzerdjeb, N., Bernadach, M., Bertolus, C., Biet, A., Bodmer, D., Boisselier, P., Boulagnon-Rombi, C., Bozec, L., Grayeli, A.Bozorg, Brenet, E., Brugel, L., Calais, G., Calugaru, V., Camby, S., Casiraghi, O., Cassagnau, E., Castain, C., Castelli, J., Ceruse, P., Chabolle, F., Chevalier, D., Choussy, O., Clatot, F., Constans, J.M., Coste, A., Coste, F., Costes, V., Cottier, J.P., Coutte, A., Cristofari, J.P., Cupissol, D., Delgrande, J., Delord, J.P., Devauchelle, B., Digue, L., Dolivet, G., Doré, M., Duflo, S., Dufour, X., Dupin, C., Eker, E., Even, C., Evrard, C., Fabiano, E., Faivre, S., Fakhry, N., Ferrand, F.R., Frandon, J., Franetti, D., de Gabory, L., Galy, C., Garcier, M., Garrel, R., Gauthier, H., Gilain, L., Guihard, S., Guillerm, S., Halimi, C., Hans, S., Herman, P., Houessinon, A., Hourseau, M., Huguet, F., Jadaud, E., Jankowski, R., Jeanne, C., Jegoux, F., Juliéron, M., Kaci, R., Kaminsky, M.-C., de Kermadec, H., Kolb, F., Kreps, S., Laadhari, M., Saint Guily, J. Lacau, Laccoureye, L., Lae, M., Lagarde, F., Lagrange, A., Lallemant, B., Lamuraglia, M., Lang, P., Lapeyre, M., Lapierre, A., Cardon, A.Lasne, Le Tourneau, C., Lefebvre, G., Lefevre, M., Lelonge, Y., Leroy, X., Lesnik, M., Liem, X., Linassier, C., Maingon, P., Majoufre, C., Malard, O., Malouf, G., Marchand, C., Marie, J.-P., Maurina, T., Mauvais, O., Merol, J.-C., Michel, J., Mineur, G., Mirafzal, S., Mirghani, H., Modesto, A., Molinier-Blossier, S., de Monès, E., Morinière, S., Mouawad, F., Moya-Plana, A., Muller, L., Musat, E., Nguyen, F., Noel, G., Obongo-Anga, F.R., Onea, M., Orliac, H., Page, C., Patron, V., Pestre, J., Dang, N. Pham, Philouze, P., Poissonnet, G., Pons, C., Pouliquen, C., J.-M.Prades, Prevost, A., Queiros, C., Rahmani, A., Rambeau, A., Ramin, L., Renard, S., Siegfried, A., Righini, C.A., Rolland, F., Saada, E., Sacino, F., Salas, S., Saroul, N., Schultz, P., Simonaggio, A., Sterkers, O., Strunski, V., Sudaka, A., Xu-Shan, S., Taouachi, R., Tassart, M., Testelin, S., J.Thariat, David, M. Timar, Timochenko, A., Toussaint, B., Coste, E. Uro, Valette, G., Van den Abbele, T., Varoquaux, A., Vauleon, E., Vergez, S., Verillaud, B., Villa, J., Villepelet, A., Volondat, M., Vulquin, N., Wagner, I., Wassef, M., Webert, L., Wong, S., Alsugair, Ziyad, Lépine, Charles, Descotes, Françoise, Lanic, Marie-Delphine, Pissaloux, Daniel, Tirode, Franck, Lopez, Jonathan, Céruse, Philippe, Philouze, Pierre, Fieux, Maxime, Wassef, Michel, Baglin, Anne-Catherine, Mihaela, Onea, Castain, Claire, Sudaka, Anne, Uro-Coste, Emmanuelle, Champagnac, Anne, Costes-Martineau, Valérie, Laé, Marick, and Benzerdjeb, Nazim

Published
2024
Full Text
View/download PDF

6. Characterization of a Molecularly Distinct Subset of Oncocytic Pleomorphic Adenomas/Myoepitheliomas Harboring Recurrent ZBTB47-AS1: PLAG1 Gene Fusion

Author

Alsugair, Ziyad, Perrot, Jimmy, Descotes, Françoise, Lopez, Jonathan, Champagnac, Anne, Pissaloux, Daniel, Castain, Claire, Onea, Mihaela, Céruse, Philippe, Philouze, Pierre, Lépine, Charles, Lanic, Marie-Delphine, Laé, Marick, Costes-Martineau, Valérie, Benzerdjeb, Nazim, Ala-Eddine, C., Aubry, K., Babin, E., Bach, C., Badoual, C., Baglin, A.C., Barry, B., Bastit, V., Baujat, B., Benezery, K., Bensadoun, R.J., Benzerdjeb, N., Bernadach, M., Bertolus, C., Biet, A., Bodmer, D., Boisselier, P., Boulagnon-Rombi, C., Bozec, L., Grayeli, A. Bozorg, Brenet, E., Brugel, L., Calais, G., Calugaru, V., Camby, S., Casiraghi, O., Cassagnau, E., Castain, C., Castelli, J., Ceruse, P., Chabolle, F., Chevalier, D., Choussy, O., Clatot, F., Constans, J.M., Coste, A., Coste, F., Costes, V., Cottier, J.P., Coutte, A., Cristofari, J.P., Cupissol, D., Delgrande, J., Delord, J.P., Devauchelle, B., Digue, L., Dolivet, G., Doré, M., Duflo, S., Dufour, X., Dupin, C., Eker, E., Even, C., Evrard, C., Fabiano, E., Faivre, S., Fakhry, N., Ferrand, F. R., Frandon, J., Franetti, D., de Gabory, L., Galy, C., Garcier, M., Garrel, R., Gauthier, H., Gilain, L., Guihard, S., Guillerm, S., Halimi, C., Hans, S., Herman, P., Houessinon, A., Hourseau, M., Huguet, F., Jadaud, E., Jankowski, R., Jeanne, C., Jegoux, F., Juliéron, M., Kaci, R., Kaminsky, M.-C., de Kermadec, H., Kolb, F., Kreps, S., Laadhari, M., Saint Guily, J. Lacau, Laccoureye, L., Lae, M., Lagarde, F., Lagrange, A., Lallemant, B., Lamuraglia, M., Lang, P., Lapeyre, M., Lapierre, A., Cardon, A. Lasne, Le Tourneau, C., Lefebvre, G, Lefevre, M., Lelonge, Y., Leroy, X., Lesnik, M., Liem, X., Linassier, C., Maingon, P., Majoufre, C., Malard, O., Malouf, G., Marchand, C., Marie, J.-P., Maurina, T., Mauvais, O., Merol, J.-C., Michel, J., Mineur, G., Mirafzal, S., Mirghani, H., Modesto, A., Molinier-Blossier, S., de Monès, E., Morinière, S., Mouawad, F., Moya-Plana, A, Muller, L., Musat, E., Nguyen, F., Noel, G., Obongo-Anga, F.R., Onea, M., Orliac, H., Page, C., Patron, V., Pestre, J., Dang, N. Pham, Philouze, P., Poissonnet, G., Pons, C., Pouliquen, C., Prades, J.-M., Prevost, A., Queiros, C., Rahmani, A., Rambeau, A., Ramin, L., Renard, S., Righini, C.A., Rolland, F., Saada, E., Sacino, F., Salas, S., Saroul, N., Schultz, P., Simonaggio, A., Sterkers, O., Strunski, V., Sudaka, A., Xu-Shan, S., Taouachi, R., Tassart, M., Testelin, S., Thariat, J., David, M. Timar, Timochenko, A., Toussaint, B., Coste, E. Uro, Valette, G., Van den Abbele, T., Varoquaux, A., Vauleon, E., Vergez, S., Verillaud, B., Villa, J., Villepelet, A., Volondat, M., Vulquin, N., Wagner, I., Wassef, M., Webert, L., and Wong, S.

Published
2024
Full Text
View/download PDF

7. Carcinomas of the external auditory canal: Management and results: A multicenter REFCOR propensity score matching study

Author

Brenet, Esteban, Atallah, Sarah, Guerlain, Joanne, Moya-Plana, Antoine, Verillaud, Benjamin, Kania, Romain, Bakhos, David, Philouze, Pierre, Righini, Christian-Adrien, Bozorg, Alexis, Mérol, Jean-Claude, Labrousse, Marc, Vergez, Sébastien, Fakhry, Nicolas, Gallet, Patrice, Cullié, Dorian, Malard, Olivier, Mauvais, Olivier, Fath, Léa, Schultz, Philippe, Dufour, Xavier, Saroul, Nicolas, Evrard, Diane, Lesnik, Maria, Even, Caroline, Costes, Valérie, Thariat, Juliette, Taillandier de Gabory, Ludovic Le, Makeieff, Marc, Dubernard, Xavier, and Baujat, Bertrand

Published
2024
Full Text
View/download PDF

8. Survival outcomes, prognostic factors, and effect of adjuvant radiotherapy and prophylactic neck dissection in salivary acinic cell carcinoma: A prospective multicenter REFCOR study of 187 patients

Author

Chatelet, Florian, Ferrand, François Régis, Atallah, Sarah, Thariat, Juliette, Mouawad, François, Fakhry, Nicolas, Malard, Olivier, Even, Caroline, de Monès, Erwan, Uro-Coste, Emmanuelle, Benzerdjeb, Nazim, Hans, Stéphane, Testelin, Sylvie, Mauvais, Olivier, Evrard, Diane, Bastit, Vianney, Salas, Sébastien, Espitalier, Florent, Classe, Marion, Digue, Laurence, Doré, Mélanie, Wong, Stéphanie, Dupin, Charles, Nguyen, France, Bettoni, Jeremie, Lapierre, Ariane, Colin, Emilien, Philouze, Pierre, Vergez, Sébastien, Baujat, Bertrand, Herman, Philippe, and Verillaud, Benjamin

Published
2023
Full Text
View/download PDF

10. Uncovering the WWTR1::NCOA2 Gene fusion in low‐grade myoepithelial‐rich neoplasm with HMGA2 expression: A case report

Author

Alsugair, Ziyad, primary, Pissaloux, Daniel, additional, Descotes, Françoise, additional, Tirode, Franck, additional, Lopez, Jonathan, additional, Perrot, Jimmy, additional, Lapierre, Ariane, additional, Fieux, Maxime, additional, Philouze, Pierre, additional, Champagnac, Anne, additional, Onea, Mihaela, additional, and Benzerdjeb, Nazim, additional

Published
2024
Full Text
View/download PDF

12. Influence of postoperative radiotherapy target volumes in unilateral head and neck carcinoma of unknown primary: A multicentric study using propensity score

Author

Brenet, Esteban, Philouze, Pierre, Schiffler, Camille, Pommier, Pascal, Crozes, Carole, Benzerdjeb, Nazim, Monchet, Elodie, Boulagnon-Rombi, Camille, Ton Van, Jean, Podeur, Fabien, Servagi-Vernat, Stéphanie, Liem, Xavier, Merol, Jean-Claude, Ceruse, Philippe, Serre, Anne-Agathe, Chabaud, Sylvie, Julieron, Morbize, and Deneuve, Sophie

Published
2021
Full Text
View/download PDF

13. History of tonsillectomy and risk of oropharyngeal cancer

Author

Combes, Jean-Damien, Voisin, Nicolas, Périé, Sophie, Malard, Olivier, Jegoux, Franck, Nadjingar, Ritoungarte, Buiret, Guillaume, Philouze, Pierre, Garrel, Renaud, Vergez, Sébastien, Fakhry, Nicolas, Righini, Christian, Mirghani, Haitham, Lerat, Justine, Saroul, Nicolas, Verillaud, Benjamin, Bartaire, Emmanuel, Céruse, Philippe, Clifford, Gary M., Franceschi, Silvia, and Lacau St Guily, Jean

Published
2021
Full Text
View/download PDF

14. Peculiar nuclear atypia associated with MDM2 gene amplification in carcinoma ex‐pleomorphic adenoma harbouring an alteration of HMGA2.

Author

Alsugair, Ziyad, Fieux, Maxime, Descotes, Françoise, Lopez, Jonathan, Cordonnier, Carolle, Russel, Juliette, Champagnac, Anne, Pissaloux, Daniel, Céruse, Philippe, Philouze, Pierre, and Benzerdjeb, Nazim

Subjects
ADENOMA, GENE amplification, FLUORESCENCE in situ hybridization, PROGNOSIS, RNA sequencing, SALIVARY glands
Abstract

Aims: Salivary gland neoplasms (SGN) exhibiting the HMGA2::WIF1 fusion are recognized by their resemblance to histology found in canalicular adenoma. Recently, ~20% of cases among 28 HMGA2::WIF1‐rearranged‐SGN showed malignancy and adverse outcomes (recurrence, distant metastasis, and disease‐specific mortality). Among them, MDM2/CDK4 amplifications were identified in one case. This outcome suggests that the MDM2/CDK4 amplifications could be useful to predict an aggressive course of carcinoma ex‐pleomorphic adenoma (CEPA). Methods and Results: We investigated the correlation between HMGA2 fusion and MDM2 amplification in four salivary gland neoplasms, providing detailed clinicopathological features and outcomes. Cases were selected from different institutions. Histological examination, immunohistochemistry, fluorescence in situ hybridization (FISH), RNA sequencing, and whole‐exome capture were performed. The cohort included four CEPA cases, all female, aged between 32 and 89 years. Tumours arose from the parotid gland with an average size of 24.5 mm. None exhibited recurrence or distant metastases during the 4–5 months of follow‐up. Pathologically, all cases displayed a peculiar atypical nuclei with 'gear‐like appearance'. Immunohistochemically, tumours exhibited a biphasic pattern with myoepithelial and ductal differentiation markers. All cases showed HMGA2 overexpression and MDM2 amplification by FISH and RNA sequencing. In a control cohort of MDM2 nonamplified CEPA cases, not exhibiting the peculiar nuclear atypia. Conclusions: Our findings suggest a strong correlation between HMGA2 alteration/MDM2 amplification and a peculiar nuclear atypia, advocating for their evaluation in biphasic tumours to facilitate accurate diagnosis and tailored posttumour removal monitoring. Further studies are warranted to validate these observations and elucidate their prognostic implications. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Oral and oropharyngeal cancer surgery with free-flap reconstruction in the elderly: Factors associated with long-term quality of life, patient needs and concerns. A GETTEC cross-sectional study

Author

Bozec, Alexandre, Majoufre, Claire, De Boutray, Marie, Gal, Jocelyn, Chamorey, Emmanuel, Roussel, Lise-Marie, Philouze, Pierre, Testelin, Sylvie, Coninckx, Marine, Bach, Christine, Schultz, Philippe, Garrel, Renaud, Louis, Marie-Yolande, Babin, Emmanuel, Cosmidis, Alain, Céruse, Philippe, Baujat, Bertrand, Culié, Dorian, Dassonville, Olivier, Poissonnet, Gilles, D'Andrea, Grégoire, Guerlain, Joanne, Vergez, Sébastien, and Dupret-Bories, Agnès

Published
2020
Full Text
View/download PDF

16. Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19)

Author

Moulin, Solenne, Leleu, Olivier, Leparree, Sylvie, Goasdoue, Henri, Piprot, Christine, Tourneur, Gerald, Bayart, Vincent, Lignier, Delphine, Lachaier, Emma, Khamari, Marwa, Coutte, Alexandre, Siembida, Nicolas, Houessinon, Aline, Regimbeau, Jean Marc, Chauffert, Bruno, Moreira, Aurélie, Hautefeuille, Vincent, Hee, Christine, Boone, Mathieu, Bihan, Céline, Chive, Emilie, Poulet-Potriquier, Stéphane, Fahem, Rachida, Luet, Dominique, Roquin, Guillaume, Vitellius, Carole, Cornet-Trichereau, Nathanaëlle, Caroli-Bosc, François-Xavier, Thirot-Bidault, Anne, Ropert, Stanislas, Gachet - Masson, Julie, Dehais, Mélanie, L'helgoualc'h, Gwen-Ael, Ali-Mahamadou, Ibrahim, Talfi, Safia, Belmont, Laure, Kilendo, Dieudonné, Benrezzak, Nasro, Dubief, Emeline, Conroy, Guillaume, Delique, Laurence, Basso, Maud, Pons, Isabelle, Salignon, Karine, Villing, Anne-Laure, Mougenot, Emmanuelle, Porebski, Cassandra, Guiatni, Asma, Cloarec, Nicolas, Mineur, Laurent, Bouchaud, Marie, David, Céleste, Peytier, Annie, Greletty, Thomas, Audemar, Franck, Vignes, Emanuelle, Minne, Floriane, Goldzak, Guillaume, Huysman, Fabienne, Hocine, Fayçal, Lakkis, Zaher, Mansi, Laura, Meynard, Guillaume, Almotlak, Hamadi, Klajer, Elodie, Sun, Xu-Shan, Wasselin, Julie, Catala, Pascale, Mazuy, Claire, Vandamme, Hélène, Prevost, Jean-Briac, Fadin, Aurélie, Basson, Laurent, Huguet, Jean-Baptiste, Dos Santos, Emmanuelle, Jany, Bérangère, Saad, Alain, Goutorbe, Frédéric, Oziol, Eric, Ramdani, Mohamed, Kadiri, Ouafae, Garbay, Delphine, Huet, Clotilde, Giroux Leprieur, Etienne, Teng, Wen, Monvoisin, Justine, Arnaud Coffin, Patrick, Roux, Sylvie, Orfeuvre, Hubert, Chagros, Mélanie, Pillon, Didier, Rassoul, Agathe, Poureau, Pierre Guillaume, Novello, Cécile, Ducray, François, Trouba, Cécile, Bastit, Vianney, Babin, Emmanuel, Thariat, Juliette, Leon, Vincent, Courtecuisse, Anne-Catherine, Vambre, Julie, Tack, Vincent, Desauw, Christophe, Meniai, Fatima, Peres, Christina, Esparcieux, Aurélie, Perrier, Hervé, Doux, Nathalie, Kaphan, Régis, Roques, Bertrand, Rebischung, Christine, Mille, Dominique, Fernandes, Gaëlle, Abdelli, Naceur, Jousset, Natacha, Combe, Pierre, Jonveaux, Eric, Dumont, Patrick, Kanaan, Marc, Berthelot Gras, Corinne, Panis, Valérie, Kaluzinski, Laure, Venant-Valery, Marjolène, Lam, You-Heng, Vallee, Laura, Riviere, Frédéric, Durand, Muriel, Benghadid, Dihya, Villeneuve, Emilie, Hentic Dhome, Olivia, Laurent, Lucie, Bounouar, Zedjiga, De Mestier, Louis, Dubois, Jacqueline, Eyriey, Magali, Moreau, Lionel, Ahle, Guido, Baihas, Dib, Aldabbagh, Kaïs, Degriffolet, Dominique, Sebbagh, Virginie, Seghezzi, Jean-Christophe, Lozach-Brugirard, Marion, Mandrou, Julie, Mavier, Loubna, Hennetier, Florence, Wagner, Jean-Philippe, Carola, Elisabeth, Chandirakumaran, Karthiga, Loutski, Sandrine, Cojean-Zelek, Isabelle, Bouras, Amina, Lacour, Sandrine, Froura, Fahem, Ben Nadji, Hadjer, Cattelain, Sophie, Darloy, Franck, Jolimoy Boilleau, Geneviève, Maissiat, Cyrielle, Darut-Jouve, Ariane, Lorgis, Véronique, Charifi-Alaoui, Ikram, Ghiringhelli, François, Drouillard, Antoine, Chaix, Marie, Manfredi, Sylvain, Lepage, Côme, Gagnaire, Alice, Latournerie, Marianne, jourdan, Sofia, Perrot, Nora, folia, Mireille, Minello, Anne, Jouve, Jean-Louis, Fery, Marielle, Landau, Alain, Evrard, Diane, Valenza, Bruno, Paitel, Jean-François, Chablais, Laetitia, Kreitmann, Thomas, Lancry-Lecomte, Laurence, Monard, Adrien, Faugeras, Eve, Boucheret, Paul, Glommeau, Cécile, Tchikladze, Christine, Garnier Tixidre, Claire, Long, Jérôme, Zaidi, Manel, Delabarre, Véronique, Meyzenc, Juliette, Ferrand, Loïc, Moro-Sibilot, Denis, Bouheret, Paul, Leyronnas, Cécile, Herve, Camille, Thoor, Audrey, Jacquet, Emanuelle, Roth, Gaël, Madapathage-Senanyake, Videsheka, Chupeau, Peggy, Bieber, Elsa, Rosso, Maud, Lepage, Isabelle, Priou, Frank, Laly, Margot, Aprelon, Sylvie, Sobolak, Natacha, Homokos, Helen, Pointreau, Yoann, Watelle, Fabienne, Pham-Becker, Alice, Lauridant, Géraldine, Turpin, Anthony, Dujardin, Charlotte, Lenglin, Etienne, Nienguet Tsota, Aimée, Dominguez, Sophie, Forestier, Alexandra, Nouvel, Franck, Lerooy, Justine, Ratajczak, Céline, Romano, Olivier, Brzyski, Dorothéee, Barriere, Aurélien, Genet, Dominique, Tisse, Julien, Zasadny, Xavier, Grelet, Adeline, Hennion-Imbault, Amélie, Haustraete, Eglantine, Louafi, Samy, Awad, Manal, Zekri, Younes, Cheneau, Caroline, Leissen, Nolwen, Egreteau, Joëlle, Breant, Alexandra, Sarabi, Matthieu, Labonne, Stéphanie, Forestier, Julien, Leclercq, Céline, Prunier-Bossion, Florence, Ray Coquard, Isabelle, Guillet, Marielle, Theillaumas, Aurélie, Prome, Emilie, Walter, Thomas, Philouze, Pierre, Lawo, Melody, De Talhouet, Solène, Beuvelot, Johanne, Molin, Yann, Bellecoste Martin, Marie, Saussereau, Maud, Agnelli, Lauren, Fakhry, Nicolas, Laplace, Christophe, Norguet Monnereau, Emmanuelle, Boucard, Céline, Djenad, Kahina, Fontaine, Catherine, Seitz, Jean-François, Dahan, Laétitia, Sigrand, Julie, Duluc, Muriel, Locher, Christophe, Fleury, Marjory, Brou Marie, Ange, Berkane, Ramdane, Poupblanc, Séverine, Auby, Dominique, Petran, Daniela, Texereau, Patrick, Guerineau, Elodie, Andre, Morgan, Mahjoubi, Linda, Sarrazin, Fanny, Jeanson, Sonia, Gschwend, Anthony, Birr, Virginie, Debieuvre, Didier, Fore, Mathieu, Noirclerc, Monique, Dahou, Sihem, Spaeth, Dominique, Lambotin, Mélanie, Lelu, Thomas, Linot, Benjamin, Hugon, Nathalie, Rousseau, Dominique, Castanie, Hélène, Lenne, Carole, Lortholary, Alain, Cessot, Anatole, Merzoug, Messaouda, Naudin, Cécile, Vannetzel, Jean-Michel, Aziz, Ghina, Hadj Arab, Yacine, Pernes, Stéphanie, Roche-Lachaise, Isabelle, Fiteni, Frédéric, Yahiaoui, Hadjer, Marel Lopez, Gwendoline, Oddoz, Jeanne, Peira, Fabienne, Michel, Olivier, Meunier, Jérôme, Ouahrani, Brahim, Roger, Antoine, Branco, Sonia, Nguyen, Van, Gisselbrecht, Mathilde, Hammad, Ghania, Mordant, Pierre, Stroksztejn, Magda, Pocard, Marc, Nlo Meyengue, Luc, Aparicio, Thomas, Sacco, Emmanuelle, Simon Anne, Sophie, Fabre-Guillevin, Elizabeth, Wislez, Marie, Slim, Marine, Zaanan, Aziz, Cadranel, Jacques, Pluvy, Johan, Ursu, Rénata, Geraldo, Amyrath, Lihi, Rime, Vo, Maryline, Brouk, Zohra, Colle, Raphaël, Bennamoun, Mostefa, Lacan, Fabrice, Louvet, Christophe, Mebarki, Soraya, Veyri, Marianne, Paillaud, Elena, Lucas, Christelle, Dubreuil, Olivier, Lyamani, Jamila, Idbaih, Ahmed, Agguini, Hanane, Soularue, Emilie, Canellas, Anthony, Zalcman, Gérard, Jourdaine, Clément, Verillaud, Benjamin, Herzine, Hakima, Raymond, Eric, Mathiot, Nathalie, Palmieri, Lola Jade, Epanya, Christian, Taieb, Julien, Bertrand, Eliane, Goujon, Gaël, Namour, Céline, Gazeau, Benoit, Zafirova, Biljana, Mirghani, Haitham, Belin, Catherine, Belkhir, Kahina, Gharib, Myriam, Vozy, Aurore, Amrane, Karim, Spano, Jean-Philippe, Wassermann, Johanna, Feuvret, Loic, Bachet, Jean-Baptiste, Philonenko, Sara, Guillot, Laetitia, Zabbe, Marion, Gibiat, Stéphanie, Baylot, Camille, Jouinot, Aude, Leduc, Nicolas, Vieillot, Sabine, James, Laurie, Ducerf, Camille, Blanc, Jean-Frédéric, Falandry Leger, Claire, Wautot, Virginie, Chauvenet, Marion, Vincent, Aude, Tougeron, David, Goulvent, Sandrine, Suc, Etienne, Laurenty, Anne-Pascale, Marquis, Eric, Bonnaire, Margaux, Dewolf, Maxime, Brenet, Esteban, Billard, Delphine, Litre, Claude-Fabien, Dumazet, Antoine, Botsen, Damien, Vazel, Marion, Carlier, Claire, Bonnerave, David, Marchand-Crety, Charles, Bouche, Olivier, Fosse, Patricia, Sefrioui, David, Michel, Pierre, Watson, Sarah, Neuzillet, Cindy, Torche, Fatah, Muron, Thierry, Natur, Stéphane, Desgrippes, Romain, Bihel, Véronique, Ferrand, François-Régis, Leiterer, Caroline, Lavole, Julie, Moquet, Claire, Pressoir, Nathalie, Dziukala, Catherine, Ligeza Poisson, Catherine, Naji, Abdelhalim, Williet, Nicolas, Phelip, Jean-Marc, Di Palma, Fabrice, Kherrour Mehdi, Amina, Langrand-Escure, Julien, Fournel, Pierre, Pigne, Grégoire, Saban-Roche, Léa, Magne, Nicolas, Vassal, Cécile, Jacquin, Jean-Philippe, Ramirez, Carole, Vallard, Alexis, Collard, Olivier, Rivoirard, Romain, Graber, Ivan, Trager Maury, Stéphanie, Duboisset, Elodie, Ayllon Ugarte, Jorge, Rami, Dalilia, Saler, Christine, Reinbolt, Manon, Le Fevre, Clara, Ben Abdelghani, Meher, Dourthe, Louis-Marie, Perruisseau-Carrier, Joffrey, Nguimpi-Tambou, Marlène, Barret, Flavie, Di Stefano Anna, Luisa, Balthazard, Annie, Mabro, May, Vassord-Dang, Camille, Le Marchand, Mathilde, Vergniol, Julien, Pripon, Iulia, Daemaegdt, Axelle, Latry, Vanessa, Larrieu, Muna, Landry, Gaëlle, Touihri Maximin, Laetitia, Del Piano, Francesco, Barlet, Agnès, Vernisse, Mylène, Lafond, Sophie, Genin, Charline, Sibertin-Blanc, Camille, Chabrillac, Emilien, Gregoire, Caroline, Vergez, Sébastien, Panouille, Quentin, Guimbaud, Rosine, Richa, Floriane, Lebellec, Loïc, Gounin, Sophie, Buiret, Guillaume, Baudin, Marine, Hamon, Hervé, Deshorgue, Anne-Claire, Barrascout, Eduardo, Legrand, Stéphanie, Houlze, Morgane, Cambula, Linda, Lopez, Anthony, Fouquet, Guillaume, Touabi, Kahina, GermaIn, Adeline, Godbert, Benoit, Voivret, Florence, Perrin, Julie, Da Silva, Rosa, Bernichon, Emilie, Lièvre, Astrid, Ray-Coquard, Isabelle, Le Malicot, Karine, Paoletti, Xavier, Bouché, Olivier, Aldabbagh, Kais, Colle, Raphael, Hardy-Bessard, Anne-Claire, Colomba, Emeline, Bourhis, Jean, Gorphe, Philippe, Ursu, Renata, and Di Stefano, Anna Luisa

Published
2020
Full Text
View/download PDF

18. A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors

Author

Atallah, Sarah, Casiraghi, Odile, Fakhry, Nicolas, Wassef, Michel, Uro-Coste, Emmanuelle, Espitalier, Florent, Sudaka, Anne, Kaminsky, Marie Christine, Dakpe, Stéphanie, Digue, Laurence, Bouchain, Olivier, Morinière, Sylvain, Hourseau, Muriel, Bertolus, Chloé, Jegoux, Franck, Thariat, Juliette, Calugaru, Valentin, Schultz, Philippe, Philouze, Pierre, Mauvais, Olivier, Righini, Christian A., Badoual, Cécile, Saroul, Nicolas, Goujon, Jean Michel, Marie, Jean Paul, Taouachi, Rabah, Brenet, Esteban, Aupérin, Anne, and Baujat, Bertrand

Published
2020
Full Text
View/download PDF

19. Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study

Author

Atallah, Sarah, Moya-Plana, Antoine, Malard, Olivier, Poissonnet, Gilles, Fakhry, Nicolas, Bettoni, Jérémie, Gallet, Patrice, Ransy, Pierre, Vergez, Sebastien, De Gabory, Ludovic, Evrard, Diane, Lesnik, Maria, Philouze, Pierre, Bertolus, Chloé, Schultz, Philippe, Morinière, Sylvain, Bastit, Vianney, Righini, Christian A., Mirghani, Haitham, Jegoux, Franck, Mauvais, Olivier, Biau, Julian, Dufour, Xavier, Bon-Mardion, Nicolas, Brenet, Esteban, Verillaud, Benjamin, and Baujat, Bertrand

Published
2020
Full Text
View/download PDF

20. Investigating oral somatosensory perception and oral symptoms of head and neck cancer patients:insights on eating behaviour

Author

Riantiningtyas, Reisya Rizki, Dougkas, Anestis, Bredie, Wender L.P., Kwiecien, Camille, Bruyas, Amandine, Philouze, Pierre, Giboreau, Agnès, Carrouel, Florence, Riantiningtyas, Reisya Rizki, Dougkas, Anestis, Bredie, Wender L.P., Kwiecien, Camille, Bruyas, Amandine, Philouze, Pierre, Giboreau, Agnès, and Carrouel, Florence

Abstract

Purpose: Sensory alterations and oral manifestations are prevalent among head and neck cancer (HNC) patients. While taste and smell alterations have been thoroughly investigated, studies on their oral somatosensory perception remain limited. Building upon our previous publication that primarily focused on objective somatosensory measurements, the present work examined self-reported sensory perception, including somatosensation and oral symptoms, in HNC patients and evaluated their link with eating behaviour. Methods: A cross-sectional study was conducted using self-reported questionnaires on sensory perception, oral symptoms, sensory-related food preference, and eating behaviour among HNC patients (n = 30). Hierarchical clustering analysis was performed to categorise patients based on their sensory perception. Correlations between oral symptoms score, sensory perception, sensory-related food preference, and eating behaviour were explored. Results: Two distinct sensory profiles of patients were identified: no alteration (n = 14) and alteration (n = 16) group. The alteration group showed decreased preference towards several sensory modalities, especially the somatosensory. Concerning eating behaviour, more patients in the alteration group agreed to negatively connotated statements (e.g. having food aversion and eating smaller portions), demonstrating greater eating difficulties. In addition, several oral symptoms related to salivary dysfunction were reported. These oral symptoms were correlated with sensory perception, sensory-related food preference, and eating behaviour. Conclusion: This study presented evidence demonstrating that sensory alterations in HNC patients are not limited to taste and smell but cover somatosensory perception and are linked to various aspects of eating. Moreover, patients reported experiencing several oral symptoms. Those with sensory alterations and oral symptoms experienced more eating difficulties.

Published
2024

22. Characterization of a Molecularly Distinct Subset of Oncocytic Pleomorphic Adenomas/Myoepitheliomas Harboring Recurrent ZBTB47-AS1::PLAG1 Gene Fusion.

Author

Alsugair, Ziyad, Perrot, Jimmy, Descotes, Françoise, Lopez, Jonathan, Champagnac, Anne, Pissaloux, Daniel, Castain, Claire, Onea, Mihaela, Céruse, Philippe, Philouze, Pierre, Lépine, Charles, Lanic, Marie-Delphine, Laé, Marick, Costes-Martineau, Valérie, Benzerdjeb, Nazim, Ala-Eddine, C., Aubry, K., Babin, E., Bach, C., and Badoual, C.

Published
2024
Full Text
View/download PDF

23. Functional or radical surgical treatment of laryngeal chondrosarcoma, analysis of survival and prognostic factors: A REFCOR and NetSarc-ResOs multicenter study of 74 cases

Author

Gazda, Pierre, primary, Baujat, Bertrand, additional, Sarini, Jérôme, additional, Gomez-Brouchet, Anne, additional, Philouze, Pierre, additional, Moya-Plana, Antoine, additional, Malard, Olivier, additional, Fakhry, Nicolas, additional, Del Pujol, Erwan De Mones, additional, Garrel, Renaud, additional, Page, Cyril, additional, Mouawad, Francois, additional, Vaz, Emmanuelle, additional, Evrard, Diane, additional, Bach, Christine, additional, Dufour, Xavier, additional, Lelonge, Yann, additional, Schultz, Philippe, additional, Mauvais, Olivier, additional, Brenet, Esteban, additional, Vergez, Sébastien, additional, and Atallah, Sarah, additional

Published
2023
Full Text
View/download PDF

24. Management of 80 sinonasal undifferentiated carcinomas. Retrospective multicentre study of the French Network of Rare Head and Neck Cancers (REFCOR)

Author

Pouvreau, Pierre, primary, Coelho, Julien, additional, Rumeau, Cécile, additional, Malard, Olivier, additional, Garrel, Renaud, additional, Michel, Justin, additional, Righini, Christian, additional, Vergez, Sebastien, additional, Baudouin, Robin, additional, Bastit, Vianney, additional, Marie, Jean-Paul, additional, Villepelet, Aude, additional, Moya-Plana, Antoine, additional, Philouze, Pierre, additional, Saroul, Nicolas, additional, Digue, Laurence, additional, Daste, Amaury, additional, Renard, Sophie, additional, Moriniere, Sylvain, additional, Carsuzaa, Florent, additional, Verillaud, Benjamin, additional, Poissonnet, Gilles, additional, Schultz, Philippe, additional, Brenet, Esteban, additional, Mouawad, François, additional, Thariat, Juliette, additional, Vulquin, Noémie, additional, Castain, Claire, additional, de Gabory, Ludovic, additional, and Dupin, Charles, additional

Published
2023
Full Text
View/download PDF

27. Treatment strategy in laryngeal chondrosarcoma: a multicenter study of 43 cases

Author

Schleich, Marianne, primary, Laccourreye, Laurent, additional, Marianowski, Remi, additional, Dufour, Xavier, additional, Babin, Emmanuel, additional, Bastit, Vianney, additional, Marie, Jean Paul, additional, Badoual, Cécile, additional, Philouze, Pierre, additional, Espitalier, Florent, additional, Du Bouexic De Pinieux, Gonzague, additional, and Moriniere, Sylvain, additional

Published
2023
Full Text
View/download PDF

28. Characterization of a Molecularly Distinct Subset of Oncocytic Pleomorphic Adenomas/Myoepitheliomas Harboring Recurrent ZBTB47-AS1::PLAG1Gene Fusion

Author

Alsugair, Ziyad, Perrot, Jimmy, Descotes, Françoise, Lopez, Jonathan, Champagnac, Anne, Pissaloux, Daniel, Castain, Claire, Onea, Mihaela, Céruse, Philippe, Philouze, Pierre, Lépine, Charles, Lanic, Marie-Delphine, Laé, Marick, Costes-Martineau, Valérie, Benzerdjeb, Nazim, Ala-Eddine, C., Aubry, K., Babin, E., Bach, C., Badoual, C., Baglin, A.C., Barry, B., Bastit, V., Baujat, B., Benezery, K., Bensadoun, R.J., Benzerdjeb, N., Bernadach, M., Bertolus, C., Biet, A., Bodmer, D., Boisselier, P., Boulagnon-Rombi, C., Bozec, L., Grayeli, A. Bozorg, Brenet, E., Brugel, L., Calais, G., Calugaru, V., Camby, S., Casiraghi, O., Cassagnau, E., Castain, C., Castelli, J., Ceruse, P., Chabolle, F., Chevalier, D., Choussy, O., Clatot, F., Constans, J.M., Coste, A., Coste, F., Costes, V., Cottier, J.P., Coutte, A., Cristofari, J.P., Cupissol, D., Delgrande, J., Delord, J.P., Devauchelle, B., Digue, L., Dolivet, G., Doré, M., Duflo, S., Dufour, X., Dupin, C., Eker, E., Even, C., Evrard, C., Fabiano, E., Faivre, S., Fakhry, N., Ferrand, F. R., Frandon, J., Franetti, D., de Gabory, L., Galy, C., Garcier, M., Garrel, R., Gauthier, H., Gilain, L., Guihard, S., Guillerm, S., Halimi, C., Hans, S., Herman, P., Houessinon, A., Hourseau, M., Huguet, F., Jadaud, E., Jankowski, R., Jeanne, C., Jegoux, F., Juliéron, M., Kaci, R., Kaminsky, M.-C., de Kermadec, H., Kolb, F., Kreps, S., Laadhari, M., Saint Guily, J. Lacau, Laccoureye, L., Lae, M., Lagarde, F., Lagrange, A., Lallemant, B., Lamuraglia, M., Lang, P., Lapeyre, M., Lapierre, A., Cardon, A. Lasne, Le Tourneau, C., Lefebvre, G, Lefevre, M., Lelonge, Y., Leroy, X., Lesnik, M., Liem, X., Linassier, C., Maingon, P., Majoufre, C., Malard, O., Malouf, G., Marchand, C., Marie, J.-P., Maurina, T., Mauvais, O., Merol, J.-C., Michel, J., Mineur, G., Mirafzal, S., Mirghani, H., Modesto, A., Molinier-Blossier, S., de Monès, E., Morinière, S., Mouawad, F., Moya-Plana, A, Muller, L., Musat, E., Nguyen, F., Noel, G., Obongo-Anga, F.R., Onea, M., Orliac, H., Page, C., Patron, V., Pestre, J., Dang, N. Pham, Philouze, P., Poissonnet, G., Pons, C., Pouliquen, C., Prades, J.-M., Prevost, A., Queiros, C., Rahmani, A., Rambeau, A., Ramin, L., Renard, S., Righini, C.A., Rolland, F., Saada, E., Sacino, F., Salas, S., Saroul, N., Schultz, P., Simonaggio, A., Sterkers, O., Strunski, V., Sudaka, A., Xu-Shan, S., Taouachi, R., Tassart, M., Testelin, S., Thariat, J., David, M. Timar, Timochenko, A., Toussaint, B., Coste, E. Uro, Valette, G., Van den Abbele, T., Varoquaux, A., Vauleon, E., Vergez, S., Verillaud, B., Villa, J., Villepelet, A., Volondat, M., Vulquin, N., Wagner, I., Wassef, M., Webert, L., and Wong, S.

Abstract

Recurrent gene fusions are common in salivary gland tumors including benign tumors, such as pleomorphic adenoma (PA) and myoepithelioma (ME). In cases where chromosomal rearrangement is identified in the pleomorphic adenoma gene 1 (PLAG1)gene, different gene partners are found. Oncocytic metaplasia, characterized by oncocytes with abundant eosinophilic granular cytoplasm and hyperchromatic nuclei, is a well-known phenomenon in salivary gland neoplasms. However, the pure oncocytic variant of PA/ME showed PLAG1gene rearrangements involving various gene partners at the molecular level, without any recurrent fusion being found. Our study includes 20 cases of PA/ME, with 11 females and 9 males. The age of patients ranged from 37 to 96 years, with a median age of 62.8 years. Most tumors originate from the parotid gland. The median size of the tumor was 26.5 mm (range: 13 to 60 mm). Among the 20 cases, 14 were a pure oncocytic variant of PA/ME, whereas 6 cases showed focal oncocytic or oncocytic-like aspects. Molecular studies on 20 cases of PA/ME were conducted. A novel recurrent ZBTB47-AS1::PLAG1fusion was identified in 6 of 12 cases with pure oncocytic metaplasia, whereas the other cases had PLAG1gene fusion with different gene partners. The transcriptomic analysis of the cases harboring ZBTB47-AS1::PLAG1fusion demonstrated that these tumors have a distinct molecular profile from conventional PA/ME. This study reveals a unique subset in the oncocytic PA/ME spectrum characterized by pure oncocytic morphology with larger oncocytic cells and recurrent ZBTB47-AS1::PLAG1fusion. It also highlights the transcriptomic distinctness of salivary gland adenomas with pure oncocytic metaplasia in the spectrum of salivary gland neoplasms. Further studies are needed to better understand the oncocytic variant of PA/ME and to determine the true nature of oncocytic cells in PA/ME.

Published
2024
Full Text
View/download PDF

29. Transoral Laser Microsurgery versus Robot-Assisted Surgery for Squamous Cell Carcinoma of the Tongue Base (Oncological and Functional Results)—A Retrospective GETTEC Multicenter Study

Author

Brudasca, Ioana, primary, Philouze, Pierre, additional, Morinière, Sylvain, additional, Lallemant, Benjamin, additional, Vergez, Sébastien, additional, Malard, Olivier, additional, Roux, Pierre-Eric, additional, Rossello, Noémie, additional, Payen, Caroline, additional, and Céruse, Philippe, additional

Published
2023
Full Text
View/download PDF

30. Liste des auteurs

Author

Barry, Béatrix, primary, Malard, Olivier, additional, Morinière, Sylvain, additional, Babin, Emmanuel, additional, Badoual, Cécile, additional, Baujat, Bertrand, additional, Bidault, François, additional, de Bonnecaze, Guillaume, additional, Bozec, Alexandre, additional, Céruse, Philippe, additional, Chabrillac, Émilien, additional, Chevalier, Dominique, additional, Choussy, Olivier, additional, Colombe, Cindy, additional, Debry, Christian, additional, Deneuve, Sophie, additional, Dubrulle, Frédérique, additional, Dupret-Bories, Agnès, additional, Espitalier, Florent, additional, Fakhry, Nicolas, additional, Fath, Léa, additional, Gavid, Marie, additional, Guerlain, Joanne, additional, Guiquerro, Sophie, additional, Heutte, Natacha, additional, Janot, François, additional, Jégoux, Franck, additional, Saint-Guily, Jean Lacau, additional, Laccourreye, Ollivier, additional, Lasne-Cardon, Audrey, additional, Lépine, Charles, additional, Lombard, Marine, additional, Mouawad, François, additional, Philouze, Pierre, additional, Pointreau, Yoann, additional, Prades, Jean Michel, additional, de Raucourt, Dominique, additional, Righini, Christian Adrien, additional, Rolland, Frédéric, additional, Santini, Laure, additional, Schultz, Philippe, additional, Tessier, Christophe, additional, Thariat, Juliette, additional, Vergez, Sébastien, additional, Werner, Alfred, additional, and Woisard, Virginie, additional

Published
2019
Full Text
View/download PDF

33. A New Animal Model of Laryngeal Transplantation

Author

Philouze, Pierre, primary, Malard, Olivier, additional, Albert, Sébastien, additional, Badet, Lionel, additional, Baujat, Bertrand, additional, Faure, Frédéric, additional, Fuchsmann, Carine, additional, Jegoux, Franck, additional, Lacau-St-Guily, Jean, additional, Marie, Jean-Paul, additional, Ramade, Antoine, additional, Vergez, Sebastien, additional, Ceruse, Philippe, additional, and Gauthier, Olivier J., additional

Published
2022
Full Text
View/download PDF

35. Abstract 3493: Comprehensive analysis of the DNA repair enzyme signature in tumor and blood cells from head and neck cancer patients and correlation with clinical data from a 18-months follow-up study

Author

Sauvaigo, Sylvie, primary, Muggiolu, Giovanna, additional, Libert, Sarah, additional, Treillard, Bertrand, additional, Alphonse, Gersende, additional, Righini, Christian A., additional, Ceruse, Philippe, additional, Philouze, Pierre, additional, and Rodriguez-Lafrasse, Claire, additional

Published
2022
Full Text
View/download PDF

36. Circulating Tumor Cell Detection during Neoadjuvant Chemotherapy to Predict Early Response in Locally Advanced Oropharyngeal Cancers: A Prospective Pilot Study

Author

Gauthier, Arnaud, primary, Philouze, Pierre, additional, Lauret, Alexandra, additional, Alphonse, Gersende, additional, Malesys, Céline, additional, Ardail, Dominique, additional, Payen, Léa, additional, Céruse, Philippe, additional, Wozny, Anne-Sophie, additional, and Rodriguez-Lafrasse, Claire, additional

Published
2022
Full Text
View/download PDF

37. CD44, γ-H2AX, and p-ATM Expressions in Short-Term Ex Vivo Culture of Tumour Slices Predict the Treatment Response in Patients with Oral Squamous Cell Carcinoma

Author

Philouze, Pierre, primary, Gauthier, Arnaud, additional, Lauret, Alexandra, additional, Malesys, Céline, additional, Muggiolu, Giovanna, additional, Sauvaigo, Sylvie, additional, Galmiche, Antoine, additional, Ceruse, Philippe, additional, Alphonse, Gersende, additional, Wozny, Anne-Sophie, additional, and Rodriguez-Lafrasse, Claire, additional

Published
2022
Full Text
View/download PDF

38. Impact of the First Wave of the COVID-19 Pandemic on the Lyon University Hospital Cancer Institute (IC-HCL)

Author

Belmont, Anne-Sophie, primary, Sajous, Christophe, additional, Bruyas, Amandine, additional, Calattini, Sara, additional, Cartalat, Stéphanie, additional, Chauvenet, Marion, additional, Colombel, Marc, additional, Dalle, Stéphane, additional, Dagonneau, Tristan, additional, Darrason, Marie, additional, Devouassoux, Gilles, additional, Duruisseaux, Michaël, additional, Guillet, Marielle, additional, Glehen, Olivier, additional, Philouze, Pierre, additional, Tronc, François, additional, Walter, Thomas, additional, You, Benoît, additional, and Freyer, Gilles, additional

Published
2021
Full Text
View/download PDF

41. Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia: A Double-Blind, Randomized, Placebo-Controlled, Multicenter Trial

Author

Dupuis-Girod, Sophie, Fargeton, Anne-Emmanuelle, Grobost, Vincent, Rivière, Sophie, Beaudoin, Marjolaine, Decullier, Evelyne, Bernard, Lorraine, Bréant, Valentine, Colombet, Bettina, Philouze, Pierre, Bailly, Sabine, Faure, Frédéric, Hermann, Ruben, Hospices Civils de Lyon (HCL), BioSanté (UMR BioSanté), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), CHU Clermont-Ferrand, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Famille BMP dans l'angiogenèse et la lymphangiogenèse (BAL ), Biologie du Cancer et de l'Infection (BCI ), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Bailly, Sabine

Subjects
nasal ointment, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, epistaxis, genetic disease, lcsh:R, lcsh:Medicine, hereditary hemorrhagic telangiectasia, rare disease, nosebleeds, tacrolimus, Article, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract

Hereditary hemorrhagic telangiectasia is a rare but ubiquitous genetic disease. Epistaxis is the most frequent and life-threatening manifestation and tacrolimus, an immunosuppressive agent, appears to be an interesting new treatment option because of its anti-angiogenic properties. Our objective was to evaluate, six weeks after the end of the treatment, the efficacy on the duration of nosebleeds of tacrolimus nasal ointment, administered for six weeks to patients with hereditary hemorrhagic telangiectasia complicated by nosebleeds, and we performed a prospective, multicenter, randomized, placebo-controlled, double-blinded, ratio 1:1 phase II study. Patients were recruited from three French Hereditary Hemorrhagic Telangiectasia (HHT) centers between May 2017 and August 2018, with a six-week follow-up, and we included people aged over 18 years, diagnosed with hereditary hemorrhagic telangiectasia and epistaxis (total duration &gt, 30 min/6 weeks prior to inclusion). Tacrolimus ointment 0.1% was self-administered by the patients twice daily. About 0.1 g of product was to be administered in each nostril with a cotton swab. A total of 50 patients was randomized and treated. Mean epistaxis duration before and after treatment in the tacrolimus group were 324.64 and 249.14 min, respectively, and in the placebo group 224.69 and 188.14 min, respectively. Epistaxis duration improved in both groups, with no significant difference in our main objective comparing epistaxis before and after treatment (p = 0.77), however, there was a significant difference in evolution when comparing epistaxis before and during treatment (p = 0.04). Toxicity was low and no severe adverse events were reported. In conclusion, tacrolimus nasal ointment, administered for six weeks, did not improve epistaxis in HHT patients after the end of the treatment. However, the good tolerance, associated with a significant improvement in epistaxis duration during treatment, encouraged us to perform a phase 3 trial on a larger patient population with a main outcome of epistaxis duration during treatment and a longer treatment time.

Published
2020
Full Text
View/download PDF

44. Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19)

Author

Lièvre, Astrid, primary, Turpin, Anthony, additional, Ray-Coquard, Isabelle, additional, Le Malicot, Karine, additional, Thariat, Juliette, additional, Ahle, Guido, additional, Neuzillet, Cindy, additional, Paoletti, Xavier, additional, Bouché, Olivier, additional, Aldabbagh, Kais, additional, Michel, Pierre, additional, Debieuvre, Didier, additional, Canellas, Anthony, additional, Wislez, Marie, additional, Laurent, Lucie, additional, Mabro, May, additional, Colle, Raphael, additional, Hardy-Bessard, Anne-Claire, additional, Mansi, Laura, additional, Colomba, Emeline, additional, Bourhis, Jean, additional, Gorphe, Philippe, additional, Pointreau, Yoann, additional, Idbaih, Ahmed, additional, Ursu, Renata, additional, Di Stefano, Anna Luisa, additional, Zalcman, Gérard, additional, Aparicio, Thomas, additional, Moulin, Solenne, additional, Leleu, Olivier, additional, Leparree, Sylvie, additional, Goasdoue, Henri, additional, Piprot, Christine, additional, Tourneur, Gerald, additional, Bayart, Vincent, additional, Lignier, Delphine, additional, Lachaier, Emma, additional, Khamari, Marwa, additional, Coutte, Alexandre, additional, Siembida, Nicolas, additional, Houessinon, Aline, additional, Regimbeau, Jean Marc, additional, Chauffert, Bruno, additional, Moreira, Aurélie, additional, Hautefeuille, Vincent, additional, Hee, Christine, additional, Boone, Mathieu, additional, Bihan, Céline, additional, Chive, Emilie, additional, Poulet-Potriquier, Stéphane, additional, Fahem, Rachida, additional, Luet, Dominique, additional, Roquin, Guillaume, additional, Vitellius, Carole, additional, Cornet-Trichereau, Nathanaëlle, additional, Caroli-Bosc, François-Xavier, additional, Thirot-Bidault, Anne, additional, Ropert, Stanislas, additional, Gachet - Masson, Julie, additional, Dehais, Mélanie, additional, L'helgoualc'h, Gwen-Ael, additional, Ali-Mahamadou, Ibrahim, additional, Talfi, Safia, additional, Belmont, Laure, additional, Kilendo, Dieudonné, additional, Benrezzak, Nasro, additional, Dubief, Emeline, additional, Conroy, Guillaume, additional, Delique, Laurence, additional, Basso, Maud, additional, Pons, Isabelle, additional, Salignon, Karine, additional, Villing, Anne-Laure, additional, Mougenot, Emmanuelle, additional, Porebski, Cassandra, additional, Guiatni, Asma, additional, Cloarec, Nicolas, additional, Mineur, Laurent, additional, Bouchaud, Marie, additional, David, Céleste, additional, Peytier, Annie, additional, Greletty, Thomas, additional, Audemar, Franck, additional, Vignes, Emanuelle, additional, Minne, Floriane, additional, Goldzak, Guillaume, additional, Huysman, Fabienne, additional, Hocine, Fayçal, additional, Lakkis, Zaher, additional, Meynard, Guillaume, additional, Almotlak, Hamadi, additional, Klajer, Elodie, additional, Sun, Xu-Shan, additional, Wasselin, Julie, additional, Catala, Pascale, additional, Mazuy, Claire, additional, Vandamme, Hélène, additional, Prevost, Jean-Briac, additional, Fadin, Aurélie, additional, Basson, Laurent, additional, Huguet, Jean-Baptiste, additional, Dos Santos, Emmanuelle, additional, Jany, Bérangère, additional, Saad, Alain, additional, Goutorbe, Frédéric, additional, Oziol, Eric, additional, Ramdani, Mohamed, additional, Kadiri, Ouafae, additional, Garbay, Delphine, additional, Huet, Clotilde, additional, Giroux Leprieur, Etienne, additional, Teng, Wen, additional, Monvoisin, Justine, additional, Arnaud Coffin, Patrick, additional, Roux, Sylvie, additional, Orfeuvre, Hubert, additional, Chagros, Mélanie, additional, Pillon, Didier, additional, Rassoul, Agathe, additional, Poureau, Pierre Guillaume, additional, Novello, Cécile, additional, Ducray, François, additional, Trouba, Cécile, additional, Bastit, Vianney, additional, Babin, Emmanuel, additional, Leon, Vincent, additional, Courtecuisse, Anne-Catherine, additional, Vambre, Julie, additional, Tack, Vincent, additional, Desauw, Christophe, additional, Meniai, Fatima, additional, Peres, Christina, additional, Esparcieux, Aurélie, additional, Perrier, Hervé, additional, Doux, Nathalie, additional, Kaphan, Régis, additional, Roques, Bertrand, additional, Rebischung, Christine, additional, Mille, Dominique, additional, Fernandes, Gaëlle, additional, Abdelli, Naceur, additional, Jousset, Natacha, additional, Combe, Pierre, additional, Jonveaux, Eric, additional, Dumont, Patrick, additional, Kanaan, Marc, additional, Berthelot Gras, Corinne, additional, Panis, Valérie, additional, Kaluzinski, Laure, additional, Venant-Valery, Marjolène, additional, Lam, You-Heng, additional, Vallee, Laura, additional, Riviere, Frédéric, additional, Durand, Muriel, additional, Benghadid, Dihya, additional, Villeneuve, Emilie, additional, Hentic Dhome, Olivia, additional, Bounouar, Zedjiga, additional, De Mestier, Louis, additional, Dubois, Jacqueline, additional, Eyriey, Magali, additional, Moreau, Lionel, additional, Baihas, Dib, additional, Aldabbagh, Kaïs, additional, Degriffolet, Dominique, additional, Sebbagh, Virginie, additional, Seghezzi, Jean-Christophe, additional, Lozach-Brugirard, Marion, additional, Mandrou, Julie, additional, Mavier, Loubna, additional, Hennetier, Florence, additional, Wagner, Jean-Philippe, additional, Carola, Elisabeth, additional, Chandirakumaran, Karthiga, additional, Loutski, Sandrine, additional, Cojean-Zelek, Isabelle, additional, Bouras, Amina, additional, Lacour, Sandrine, additional, Froura, Fahem, additional, Ben Nadji, Hadjer, additional, Cattelain, Sophie, additional, Darloy, Franck, additional, Jolimoy Boilleau, Geneviève, additional, Maissiat, Cyrielle, additional, Darut-Jouve, Ariane, additional, Lorgis, Véronique, additional, Charifi-Alaoui, Ikram, additional, Ghiringhelli, François, additional, Drouillard, Antoine, additional, Chaix, Marie, additional, Manfredi, Sylvain, additional, Lepage, Côme, additional, Gagnaire, Alice, additional, Latournerie, Marianne, additional, jourdan, Sofia, additional, Perrot, Nora, additional, folia, Mireille, additional, Minello, Anne, additional, Jouve, Jean-Louis, additional, Fery, Marielle, additional, Landau, Alain, additional, Evrard, Diane, additional, Valenza, Bruno, additional, Paitel, Jean-François, additional, Chablais, Laetitia, additional, Kreitmann, Thomas, additional, Lancry-Lecomte, Laurence, additional, Monard, Adrien, additional, Faugeras, Eve, additional, Boucheret, Paul, additional, Glommeau, Cécile, additional, Tchikladze, Christine, additional, Garnier Tixidre, Claire, additional, Long, Jérôme, additional, Zaidi, Manel, additional, Delabarre, Véronique, additional, Meyzenc, Juliette, additional, Ferrand, Loïc, additional, Moro-Sibilot, Denis, additional, Bouheret, Paul, additional, Leyronnas, Cécile, additional, Herve, Camille, additional, Thoor, Audrey, additional, Jacquet, Emanuelle, additional, Roth, Gaël, additional, Madapathage-Senanyake, Videsheka, additional, Chupeau, Peggy, additional, Bieber, Elsa, additional, Rosso, Maud, additional, Lepage, Isabelle, additional, Priou, Frank, additional, Laly, Margot, additional, Aprelon, Sylvie, additional, Sobolak, Natacha, additional, Homokos, Helen, additional, Watelle, Fabienne, additional, Pham-Becker, Alice, additional, Lauridant, Géraldine, additional, Dujardin, Charlotte, additional, Lenglin, Etienne, additional, Nienguet Tsota, Aimée, additional, Dominguez, Sophie, additional, Forestier, Alexandra, additional, Nouvel, Franck, additional, Lerooy, Justine, additional, Ratajczak, Céline, additional, Romano, Olivier, additional, Brzyski, Dorothéee, additional, Barriere, Aurélien, additional, Genet, Dominique, additional, Tisse, Julien, additional, Zasadny, Xavier, additional, Grelet, Adeline, additional, Hennion-Imbault, Amélie, additional, Haustraete, Eglantine, additional, Louafi, Samy, additional, Awad, Manal, additional, Zekri, Younes, additional, Cheneau, Caroline, additional, Leissen, Nolwen, additional, Egreteau, Joëlle, additional, Breant, Alexandra, additional, Sarabi, Matthieu, additional, Labonne, Stéphanie, additional, Forestier, Julien, additional, Leclercq, Céline, additional, Prunier-Bossion, Florence, additional, Ray Coquard, Isabelle, additional, Guillet, Marielle, additional, Theillaumas, Aurélie, additional, Prome, Emilie, additional, Walter, Thomas, additional, Philouze, Pierre, additional, Lawo, Melody, additional, De Talhouet, Solène, additional, Beuvelot, Johanne, additional, Molin, Yann, additional, Bellecoste Martin, Marie, additional, Saussereau, Maud, additional, Agnelli, Lauren, additional, Fakhry, Nicolas, additional, Laplace, Christophe, additional, Norguet Monnereau, Emmanuelle, additional, Boucard, Céline, additional, Djenad, Kahina, additional, Fontaine, Catherine, additional, Seitz, Jean-François, additional, Dahan, Laétitia, additional, Sigrand, Julie, additional, Duluc, Muriel, additional, Locher, Christophe, additional, Fleury, Marjory, additional, Brou Marie, Ange, additional, Berkane, Ramdane, additional, Poupblanc, Séverine, additional, Auby, Dominique, additional, Petran, Daniela, additional, Texereau, Patrick, additional, Guerineau, Elodie, additional, Andre, Morgan, additional, Mahjoubi, Linda, additional, Sarrazin, Fanny, additional, Jeanson, Sonia, additional, Gschwend, Anthony, additional, Birr, Virginie, additional, Fore, Mathieu, additional, Noirclerc, Monique, additional, Dahou, Sihem, additional, Spaeth, Dominique, additional, Lambotin, Mélanie, additional, Lelu, Thomas, additional, Linot, Benjamin, additional, Hugon, Nathalie, additional, Rousseau, Dominique, additional, Castanie, Hélène, additional, Lenne, Carole, additional, Lortholary, Alain, additional, Cessot, Anatole, additional, Merzoug, Messaouda, additional, Naudin, Cécile, additional, Vannetzel, Jean-Michel, additional, Aziz, Ghina, additional, Hadj Arab, Yacine, additional, Pernes, Stéphanie, additional, Roche-Lachaise, Isabelle, additional, Fiteni, Frédéric, additional, Yahiaoui, Hadjer, additional, Marel Lopez, Gwendoline, additional, Oddoz, Jeanne, additional, Peira, Fabienne, additional, Michel, Olivier, additional, Meunier, Jérôme, additional, Ouahrani, Brahim, additional, Roger, Antoine, additional, Branco, Sonia, additional, Nguyen, Van, additional, Gisselbrecht, Mathilde, additional, Hammad, Ghania, additional, Mordant, Pierre, additional, Stroksztejn, Magda, additional, Pocard, Marc, additional, Nlo Meyengue, Luc, additional, Sacco, Emmanuelle, additional, Simon Anne, Sophie, additional, Fabre-Guillevin, Elizabeth, additional, Slim, Marine, additional, Zaanan, Aziz, additional, Cadranel, Jacques, additional, Pluvy, Johan, additional, Ursu, Rénata, additional, Geraldo, Amyrath, additional, Lihi, Rime, additional, Vo, Maryline, additional, Brouk, Zohra, additional, Colle, Raphaël, additional, Bennamoun, Mostefa, additional, Lacan, Fabrice, additional, Louvet, Christophe, additional, Mebarki, Soraya, additional, Veyri, Marianne, additional, Paillaud, Elena, additional, Lucas, Christelle, additional, Dubreuil, Olivier, additional, Lyamani, Jamila, additional, Agguini, Hanane, additional, Soularue, Emilie, additional, Jourdaine, Clément, additional, Verillaud, Benjamin, additional, Herzine, Hakima, additional, Raymond, Eric, additional, Mathiot, Nathalie, additional, Palmieri, Lola Jade, additional, Epanya, Christian, additional, Taieb, Julien, additional, Bertrand, Eliane, additional, Goujon, Gaël, additional, Namour, Céline, additional, Gazeau, Benoit, additional, Zafirova, Biljana, additional, Mirghani, Haitham, additional, Belin, Catherine, additional, Belkhir, Kahina, additional, Gharib, Myriam, additional, Vozy, Aurore, additional, Amrane, Karim, additional, Spano, Jean-Philippe, additional, Wassermann, Johanna, additional, Feuvret, Loic, additional, Bachet, Jean-Baptiste, additional, Philonenko, Sara, additional, Guillot, Laetitia, additional, Zabbe, Marion, additional, Gibiat, Stéphanie, additional, Baylot, Camille, additional, Jouinot, Aude, additional, Leduc, Nicolas, additional, Vieillot, Sabine, additional, James, Laurie, additional, Ducerf, Camille, additional, Blanc, Jean-Frédéric, additional, Falandry Leger, Claire, additional, Wautot, Virginie, additional, Chauvenet, Marion, additional, Vincent, Aude, additional, Tougeron, David, additional, Goulvent, Sandrine, additional, Suc, Etienne, additional, Laurenty, Anne-Pascale, additional, Marquis, Eric, additional, Bonnaire, Margaux, additional, Dewolf, Maxime, additional, Brenet, Esteban, additional, Billard, Delphine, additional, Litre, Claude-Fabien, additional, Dumazet, Antoine, additional, Botsen, Damien, additional, Vazel, Marion, additional, Carlier, Claire, additional, Bonnerave, David, additional, Marchand-Crety, Charles, additional, Bouche, Olivier, additional, Fosse, Patricia, additional, Sefrioui, David, additional, Watson, Sarah, additional, Torche, Fatah, additional, Muron, Thierry, additional, Natur, Stéphane, additional, Desgrippes, Romain, additional, Bihel, Véronique, additional, Ferrand, François-Régis, additional, Leiterer, Caroline, additional, Lavole, Julie, additional, Moquet, Claire, additional, Pressoir, Nathalie, additional, Dziukala, Catherine, additional, Ligeza Poisson, Catherine, additional, Naji, Abdelhalim, additional, Williet, Nicolas, additional, Phelip, Jean-Marc, additional, Di Palma, Fabrice, additional, Kherrour Mehdi, Amina, additional, Langrand-Escure, Julien, additional, Fournel, Pierre, additional, Pigne, Grégoire, additional, Saban-Roche, Léa, additional, Magne, Nicolas, additional, Vassal, Cécile, additional, Jacquin, Jean-Philippe, additional, Ramirez, Carole, additional, Vallard, Alexis, additional, Collard, Olivier, additional, Rivoirard, Romain, additional, Graber, Ivan, additional, Trager Maury, Stéphanie, additional, Duboisset, Elodie, additional, Ayllon Ugarte, Jorge, additional, Rami, Dalilia, additional, Saler, Christine, additional, Reinbolt, Manon, additional, Le Fevre, Clara, additional, Ben Abdelghani, Meher, additional, Dourthe, Louis-Marie, additional, Perruisseau-Carrier, Joffrey, additional, Nguimpi-Tambou, Marlène, additional, Barret, Flavie, additional, Di Stefano Anna, Luisa, additional, Balthazard, Annie, additional, Vassord-Dang, Camille, additional, Le Marchand, Mathilde, additional, Vergniol, Julien, additional, Pripon, Iulia, additional, Daemaegdt, Axelle, additional, Latry, Vanessa, additional, Larrieu, Muna, additional, Landry, Gaëlle, additional, Touihri Maximin, Laetitia, additional, Del Piano, Francesco, additional, Barlet, Agnès, additional, Vernisse, Mylène, additional, Lafond, Sophie, additional, Genin, Charline, additional, Sibertin-Blanc, Camille, additional, Chabrillac, Emilien, additional, Gregoire, Caroline, additional, Vergez, Sébastien, additional, Panouille, Quentin, additional, Guimbaud, Rosine, additional, Richa, Floriane, additional, Lebellec, Loïc, additional, Gounin, Sophie, additional, Buiret, Guillaume, additional, Baudin, Marine, additional, Hamon, Hervé, additional, Deshorgue, Anne-Claire, additional, Barrascout, Eduardo, additional, Legrand, Stéphanie, additional, Houlze, Morgane, additional, Cambula, Linda, additional, Lopez, Anthony, additional, Fouquet, Guillaume, additional, Touabi, Kahina, additional, GermaIn, Adeline, additional, Godbert, Benoit, additional, Voivret, Florence, additional, Perrin, Julie, additional, Da Silva, Rosa, additional, and Bernichon, Emilie, additional

Published
2020
Full Text
View/download PDF

46. Circulating tumor cells in the future of personalized radio(chimio)therapy for HNSCC patients

Author

Lauret, Alexandra, Philouze, Pierre, Malésys, Céline, Lopez, Jonathan, Céruse, Philippe, Alphonse, Gersende, Rodriguez-Lafrasse, Claire, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), PRISME (PRISME), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service d'ORL et de Chirurgie cervico-faciale - Hôpital Lyon-Sud, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Rayet, Béatrice

Subjects
[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.CAN] Life Sciences [q-bio]/Cancer, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.CAN]Life Sciences [q-bio]/Cancer
Abstract

International audience; The majority of Head and Neck Squamous Cell Carcinoma (HNSCC) patients have a locally advanced stage at diagnosis and unresectable tumors are treated by a combination of radio- and chemo-therapy. Locoregional recurrences and distant metastases appear in most patients, leading to a 5-year overall survival less than 50%. Metastases occur as the result of a cascade of events that begins with transition of cells from an epithelial to a mesenchymal phenotype (EMT), resulting in detachment from the primary tumor site, followed by intravasation of cells into the blood. The surviving cells, known as circulating tumor cells (CTCs), can extravasate into distant tissues where they form metastases. The presence of CTCs has been associated in different types of cancers (breast, lung) to a poor prognosis. In addition, CTCs may be partly cancer stem cells (CSCs). Early determination of the molecular profile of CTCs, which may be considered as a liquid biopsy, could therefore predict the response of HNSCC patients to radio(chemo)therapy and tumor escape.Our work focuses on the counting and molecular characterization of CTCs in a cohort of 20 patients with HNSCC recruited between May 2016 and March 2018 (NCT02714920). The 24-month follow-up is still ongoing. Blood samples and biopsies were taken at inclusion of patients and other blood samples were collected during treatment (radiochemotherapy). During the follow-up period, blood samples are taken in case of local relapse (with additional biopsy) or metastases.CTCs were isolated for each sample, counted, and their phenotype (epithelial, mesenchymal or CSC) characterized after immunohistochemical staining of specific proteins. The gene expression profile of CTCs and initial biopsies, focused on tumor progression and DNA repair pathways (Nanostring® technology), is being analyzed.Based on CTC counts and molecular signatures, we hope to rank patients as "good" and "bad" responders to treatment at an early stage of the disease and predict its progression. In the longer term, the collection of all these data will allow a better understanding of the tumor escape mechanisms to treatments and should lead to personalized and early treatment adaptation in addition to clinical data and imaging.Supported by Cancéropôle CLARA, Conseil Régional et Général du Rhône, LabEx PRIMES (ANR11LABX0063)

Published
2018

47. Comparaison du profil d’expression génique de biopsies et de cellules tumorales circulantes dans le suivi thérapeutique des cancers des VADS

Author

Lauret, Alexandra, Philouze, Pierre, Malésys, Céline, Céruse, Philippe, Lopez, Jonathan, Alphonse, Gersende, Rodriguez-Lafrasse, Claire, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), PRISME (PRISME), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service d'ORL et de Chirurgie cervico-faciale - Hôpital Lyon-Sud, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), and Rayet, Béatrice

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer, CTCs, biopsie liquide, nanostring, HNSCC
Abstract

International audience; Introduction : La survie à 5 ans des patients ayant un cancer des VADS n’excède pas 40% en raison d’un taux élevé de récidives loco-régionales et à distance. Le phénomène métastatique est gouverné par une série complexe d’évènements incluant la migration des cellules tumorales à partir du site primaire, leur passage dans la circulation sanguine et l’invasion du tissu cible. Les cellules, appelées cellules tumorales circulantes (CTCs), sont le reflet de l’agressivité et de la progression tumorale. Ce travail s’intéresse à la numération et caractérisation des CTCs chez des patients atteints de cancer des VADS en regard de l’analyse de biopsies tumorales.Méthodes : Des prélèvements sanguins et biopsiques sont réalisés avant et pendant le traitement (chimiothérapie/radiothérapie) et en cas de récidive. Les CTCs sont isolées à partir du sang (Rosette et ISET). Un marquage immunohistochimique de protéines spécifiques de cellules souches cancéreuses et de la transition épithélio-mésenchymateuse est ensuite réalisé afin de les compter et les caractériser. L’analyse transcriptomique des voies de progression tumorale et des systèmes de réparation des lésions de l’ADN est réalisée par la technologie Nanostring sur les biopsies tumorales et les CTCs (après amplification).Résultats : Dix-huit patients ont été inclus dans l’étude à ce jour. Les premiers résultats de comptage montrent une grande hétérogénéité au niveau du nombre de CTCs. Différents phénotypes (mésenchymateux ou épithéliaux) de CTCs sont mis en évidence selon les patients. L’analyse transcriptomique des biopsies et CTCs est en cours.Conclusion : La numération et la caractérisation (phénotype et profil transcriptomique) des CTCs et leur comparaison aux données des biopsies devraient permettre de définir des paramètres biologiques prédictifs de la réponse thérapeutique des cancers des VADS.Soutenu par le Cancéropôle CLARA, Grenoble-Alpes Métropole, Conseil Régional Rhône-Alpes, Conseil Général du Rhône et LabEx PRIMES

Published
2018

48. Single Nucleotide Polymorphism rs6942067 Is a Risk Factor in Young and in Non-Smoking Patients with HPV Negative Head and Neck Squamous Cell Carcinoma

Author

Cardin, Guillaume B., primary, Bernard, Monique, additional, Bahig, Houda, additional, Nguyen-Tan, Phuc Felix, additional, Ballivy, Olivier, additional, Filion, Edith, additional, Soulieres, Denis, additional, Philouze, Pierre, additional, Ayad, Tareck, additional, Guertin, Louis, additional, Bissada, Eric, additional, Rodier, Francis, additional, and Christopoulos, Apostolos, additional

Published
2019
Full Text
View/download PDF

49. Biomarqueurs prédictifs de la réponse au traitement par radiothérapie et chimiothérapie dans les cancers des VADS : résultats préliminaires de l’étude ancillaire CHEMRAD

Author

Lauret, Alexandra, Malésys, Céline, Philouze, Pierre, Céruse, Philippe, Alphonse, Gersende, Rodriguez-Lafrasse, Claire, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Service d'ORL et de Chirurgie cervico-faciale - Hôpital Lyon-Sud, and Rayet, Béatrice

Subjects
[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.CAN] Life Sciences [q-bio]/Cancer, facteurs predictifs, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.CAN]Life Sciences [q-bio]/Cancer, cancer des VADS, radiothérapie, biomarqueurs
Abstract

National audience; Introduction : Malgré la combinaison de stratégies thérapeutiques comme la chirurgie, la chimio- et radio-thérapie, la survie à 5ans des patients atteints de cancer des VADS reste inférieure à 30% en raison de l’apparition de récidives locorégionales et/ou de métastases. L’étude ancillaire ChemRad a pour but d’identifier des marqueurs biologiques de la réponse tumorale à la radio-chimiothérapie afin d’orienter précocement les patients vers la meilleure stratégie thérapeutique.Méthodes : Trois prélèvement biopsiques tumoraux et deux sanguins sont réalisés, avant traitement, pendant (chimiothérapie d’induction +/- radiothérapie ou RT seule), et en cas de récidive, sur une cohorte de 60 patients. Un des échantillons biopsiques est maintenu en culture ex vivo afin de tester la réponse à la RT, un autre est destiné à l’établissement d’une lignée primaire et le dernier permet le typage HPV et différentes analyses moléculaires. Les prélèvements sanguins sont destinés à l’isolement et l’analyse des cellules tumorales circulantes (CTCs), marqueur d’agressivité et de progression tumorale.Résultats : Les différentes étapes permettant le maintien en survie des biopsies ex-vivo ont été mises au point ainsi que le protocole d’irradiation et de suivi de la réparation des cassures double-brin de l’ADN. Le protocole d’isolement et de comptage des CTCs a été développé en parallèle ainsi que leur caractérisation immuno-histochimique, en particulier par des marqueurs de cellules souches cancéreuses et de la transition épithélio-mésenchymateuse. Une corrélation sera établie entre les résultats obtenus à partir de la biopsie, de la lignée primaire et des CTCs et la réponse au traitement des patients.Conclusion : Ce travail permettra à terme une meilleure compréhension du mécanisme d’échappement tumoral et l’identification de marqueurs prédictifs de la résistance aux traitements.

Published
2017

50. Liste des collaborateurs

Author

Abu-Shama, Yazan, Akkari, Mohamed, Alain, Sophie, Andreoletti, Laurent, Aubry, Karine, Aussedat, Charles, Barin, Francis, Bartier, Sophie, Béquignon, Émilie, Boutoille, David, Boutolleau, David, Boyez, Alice, Chauvelot, Jordan, Coste, André, Coudert, Aurélie, Couloigner, Vincent, Cussinet, Lucie, Deguine, Olivier, Di Ruggiero-Gourtaud, Régine, Duflo, Suzy, Escuret, Vanessa, Faure, Frédéric, Favier, Valentin, François, Martine, Frobert, Émilie, Gallois, Yohan, Gaymard, Alexandre, Gessain, Antoine, Gillet, Yves, Hantz, Sébastien, Hautefort, Charlotte, Hermann, Ruben, Jankowski, Roger, Lassalle-Kinic, Benoîte, Leboulanger, Nicolas, Leclère, Jean Christophe, Leparc-Goffart, Isabelle, Lévêque, Nicolas, Lina, Bruno, Marianowski, Rémi, Michel, Benoît, Mirghani, Haitham, Morand, Patrice, Parietti-Winkler, Cécile, Parsemain, Aurélie, Péré, Hélène, Philouze, Pierre, Pondaven-Letourmy, Soizic, Rameix-Welti, Marie-Anne, Rogez, Sylvie, Rouault, Marion, Simon, Francois, Stefic, Karl, Teissier, Natacha, Truy, Éric, Vabret, Astrid, Van Den Abbeele, Thierry, Vauloup-Fellous, Christelle, and Verillaud, Benjamin

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results