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4. Reference Protocol to Assess Analytical Performance of Higher Order Structural Analysis Measurements:Results from an Interlaboratory Comparison

Author

Groves, K., Ashcroft, A.E., Cryar, A., Sula, A., Wallace, B.A., Stocks, B.B., Burns, C., Cooper-Shepherd, D., De Lorenzi, E., Rodriguez, E., Zhang, H., Ault, J.R., Ferguson, J., Phillips, J.J., Pacholarz, K., Thalassinos, K., Luckau, L., Ashton, L., Durrant, O., Barran, P., Dalby, P., Vicedo, P., Colombo, R., Davis, R., Parakra, R., Upton, R., Hill, S., Wood, V., Soloviev, Z., Quaglia, M., Groves, K., Ashcroft, A.E., Cryar, A., Sula, A., Wallace, B.A., Stocks, B.B., Burns, C., Cooper-Shepherd, D., De Lorenzi, E., Rodriguez, E., Zhang, H., Ault, J.R., Ferguson, J., Phillips, J.J., Pacholarz, K., Thalassinos, K., Luckau, L., Ashton, L., Durrant, O., Barran, P., Dalby, P., Vicedo, P., Colombo, R., Davis, R., Parakra, R., Upton, R., Hill, S., Wood, V., Soloviev, Z., and Quaglia, M.

Abstract

Measurements of protein higher order structure (HOS) provide important information on stability, potency, efficacy, immunogenicity, and biosimilarity of biopharmaceuticals, with a significant number of techniques and methods available to perform these measurements. The comparison of the analytical performance of HOS methods and the standardization of the results is, however, not a trivial task, due to the lack of reference protocols and reference measurement procedures. Here, we developed a protocol to structurally alter and compare samples of somatropin, a recombinant biotherapeutic, and describe the results obtained by using a number of techniques, methods and in different laboratories. This, with the final aim to provide tools and generate a pool of data to compare and benchmark analytical platforms and define method sensitivity to structural changes. Changes in somatropin HOS, induced by the presence of zinc at increasing concentrations, were observed, both globally and at more localized resolution, across many of the methods utilized in this study and with different sensitivities, suggesting the suitability of the protocol to improve understanding of inter- and cross-platform measurement comparability and assess analytical performance as appropriate. © 2021 The Authors. Published by American Chemical Society.

Published
2021

6. Usherin defects lead to early-onset retinal dysfunction in zebrafish

Author

Dona, M.A., Slijkerman, R.W., Lerner, Kimberly, Broekman, S., Wegner, Jeremy, Howat, Taylor, Peters, T.A., Hetterschijt, L., Vrieze, E. de, Kremer, H., Phillips, J.J., WIjk, E. van, Dona, M.A., Slijkerman, R.W., Lerner, Kimberly, Broekman, S., Wegner, Jeremy, Howat, Taylor, Peters, T.A., Hetterschijt, L., Vrieze, E. de, Kremer, H., Phillips, J.J., and WIjk, E. van

Abstract

Item does not contain fulltext

Published
2018

7. First measurement of the polarization observable E in the p→(γ→,π+)n reaction up to 2.25 GeV

Author

Strauch, S., Briscoe, W.J., Doring, M., Klempt, E., Nikonov, V.A., Pasyuk, E., Ronchen, D., Sarantsev, A.V., Strakovsky, I., Workman, R., Adhikari, K.P., Adikaram, D., Anderson, M.D., Anefalos Periera, S., Anisovich, A.V., Badui, R.A., Ball, J., Batourine, V., Battaglieri, M., Bedlinskiy, I., Benmouna, N., Biselli, A.S., Brock, J., Brooks, W.K., Burkert, V.D., Cao, T., Carlin, C., Carman, D.S., Celentano, A., Chandavar, S., Charles, G., Colerani, L., Cole, P.L., Compton, N., Contalbrigo, M., Cortes, O., Crede, V., Dasjyan, N., D'Angelo, A., De Vita, R., De Sanctis, E., Deur, A., Djalali, C., Dugger, M., Dupre, R., Egiyan, H., El Alaoui, A., El Fassi, L., Elouadrhiri, L., Eugenio, P., Fedotov, G., Fegan, S., Filippi, A., Fleming, J.A., Forest, T.A., Fradi, A., Gevorgyna, N., Ghandilyan, Y., Giovanetti, K.L., Girod, F.X., Glazier, D.I., Gohn, W., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Hanretty, C., Harrison, N., Hattawy, M., Hicks, K., Ho, D., Holtrop, M., Hughes, S.M., Ilyeva, Y., Ireland, D.G., Ishkanov, B.S., Isupov, E.L., Jenkins, D., Jiang, H., Jo, H.S., Joo, K., Joosten, S., Keith, C.D., Keller, D., Khachatryan, G., Khandaker, M., Kim, A., Kim, W., Klein, A., Klein, F.J., Kubarovsky, V., Kuhn, S.E., Lenisa, P., Livingston, K., Lu, H.Y., MacGregor, I.J.D., Markov, N., McKinnon, B., Meekins, D.G., Meyer, C.A., Mokeev, V., Montgomery, R.A., Moody, C.I., Moutarde, H., Movsisyan, A., Munevar, E., Munoz Camacho, C., Badel-Turonski, P., Net, L.A., Niccolai, S., Niculescu, G., Niculescu, I., O'Reilley, G., Osipenko, M., Ostrovidov, A.I., Park, K., Peng, P., Phelps, W., Phillips, J.J, Pisano, S., Pogorelko, O., Pozdniakov, S., Price, J.W., Procureur, S., Prok, Y., Protopopescu, D., Puckett, A.J.R., Raue, B.A., Ripani, M., Ritchie, B.G., Rizzo, A., Rosner, G., Roy, P., Sabatie, F., Salgado, C., Schott, D., Schumacher, R.A., Seder, E., Seely, M.L., Senderovich, I., Sharabian, Y.G., Simonyan, A., Skorodumina, I., Smith, G.D., Sober, D.I., Sokhan, D., Sparveris, N., Stoler, P., Stepanyan, S., Sytnik, V., Taiuti, M., Tian, Y., Trivedi, A., Tucker, R., Ungaro, M., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Wei, X., Wood, M.H., Zachariou, N., Zana, L., Zhang, J., Zhao, Z.W., and Zonta, I.

Subjects
Polarization observables, Nuclear and High Energy Physics, Baryon spectroscopy, FROST experiment, Pion photoproduction, Socio-culturale, lcsh:QC1-999, Settore FIS/04 - Fisica Nucleare e Subnucleare, Nuclear Experiment, QC, lcsh:Physics
Abstract

First results from the longitudinally polarized frozen-spin target (FROST) program are reported. The double-polarization observable E , for the reaction View the MathML source, has been measured using a circularly polarized tagged-photon beam, with energies from 0.35 to 2.37 GeV. The final-state pions were detected with the CEBAF Large Acceptance Spectrometer in Hall B at the Thomas Jefferson National Accelerator Facility. These polarization data agree fairly well with previous partial-wave analyses at low photon energies. Over much of the covered energy range, however, significant deviations are observed, particularly in the high-energy region where high-L multipoles contribute. The data have been included in new multipole analyses resulting in updated nucleon resonance parameters. We report updated fits from the Bonn–Gatchina, Jülich–Bonn, and SAID groups.

Published
2015
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8. Measurements of $ep \to e'\pi^+n$ at 1.6 < W < 2.0 GeV and extraction of nucleon resonance electrocouplings at CLAS

Author

Park, K., Aznauryan, I.G., Burkert, V.D., Adhikari, K.P., Amaryan, M.J., Pereira, S. Anefalos, Avakian, H., Battaglieri, M., Badui, R., Bedlinskiy, I., Biselli, A.S., Bono, J., Briscoe, W.J., Brooks, W.K., Carman, D.S., Celentano, A., Chandavar, S., Charles, G., Colaneri, L., Cole, P.L., Contalbrigo, M., Cortes, O., Crede, V., D'Angelo, A., Dashyan, N., Vita, R. De, Sanctis, E. De, Deur, A., Djalali, C., Doughty, D., Dupre, R., Egiyan, H., Alaoui, A. El, Elouadrhiri, L., Fassi, L. El, Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Filippi, A., Fleming, J.A., Garillon, B., Garçon, M., Gevorgyan, N., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Joo, H.S., Goetz, J.T., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guegan, B., Guidal, M., Guo, L., Hakobyan, H., Hanretty, C., Hattawy, M., Hicks, K., Holtrop, M., Hughes, S.M., Hyde, C. E., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jenkins, D., Jiang, H., Jo, H.S., Joo, K., Joosten, S., Keller, D., Khandaker, M., Kim, A., Kim, W., Klein, A., Klein, F.J., Kubarovsky, V., Kuhn, S.E., Kuleshov, S.V., Lenisa, P., Livingston, K., Lu, H.Y., MacGregor, I .J .D., Markov, N., Martinez, David, Mckinnon, B., Mokeev, V., Montgomery, R.A., Moutarde, H., Muñoz Camacho, C., Nadel-Turonski, P., Niccolai, S., Niculescu, G., Niculescu, I., Osipenko, M., Ostrovidov, A.I., Paolone, M., Pasyuk, E., Peng, P., Phelps, W., Phillips, J.J., Pisano, S., Pogorelko, O., Price, J.W., Procureur, S., Prok, Y., Protopopescu, D., Puckett, A.J.R., Raue, B.A., Ripani, M., Rizzo, A., Rosner, G., Rossi, P., Roy, Pascal, Sabatié, F., Salgado, C., Schott, D., Schumacher, R.A., Seder, E., Sharabian, Y.G., Simonyan, A., Skorodumina, Iu., Smith, E.S., Smith, G.D., Sparveris, N., Stoler, P., Strakovsky, I.I., Strauch, S., Sytnik, V., Taiuti, M., Tang, W., Taylor, C.E., Tian, Ye, Trivedi, A., Ungaro, M., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Wei, X., Weinstein, L.B., Wood, M.H., Zachariou, N., Zana, L., Zhang, J., Zhao, Z.W., Zonta, I., Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CLAS, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment
Abstract

Differential cross sections of the exclusive process $e p \to e^\prime \pi^+ n$ were measured with good precision in the range of the photon virtuality $Q^2 = 1.8 - 4.5$ GeV$^2$, and the invariant mass range of the $\pi^+ n$ final state W = 1.6 - 2.0 GeV using the CEBAF Large Acceptance Spectrometer. Data were collected with nearly complete coverage in the azimuthal and polar angles of the $n\pi^+$ center-of-mass system. More than 37,000 cross section points were measured. The contributions of the isospin $I = {1\over 2}$ resonances $N(1675){5\over 2}^-$, $N(1680){5\over 2}^+$ and $N(1710){1\over 2}^+$ were extracted at different values of $Q^2$ using a single-channel, energy-dependent resonance amplitude analysis. Two different approaches, the unitary isobar model and the fixed-$t$ dispersion relations, were employed in the analysis. We observe significant strength of the $N(1675){5\over 2}^-$ in the $A_{1/2}$ amplitude, which is in strong disagreement with quark models that predict both transverse amplitudes to be strongly suppressed. For the $N(1680){5\over 2}^+$ we observe a slow changeover from the dominance of the $A_{3/2}$ amplitude at the real photon point ($Q^2=0$) to a $Q^2$ where $A_{1/2}$ begins to dominate. The scalar amplitude $S_{1/2}$ drops rapidly with $Q^2$ consistent with quark model prediction. For the $N(1710){1\over 2}^+$ resonance our analysis shows significant strength for the $A_{1/2}$ amplitude at $Q^2 < 2.5$ GeV$^2$., Comment: 24 pages, 22 figures. arXiv admin note: substantial text overlap with arXiv:0709.1946

Published
2015
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9. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Author

Sturm, D., Orr, B.A., Toprak, U.H., Hovestadt, V., Jones, D.T., Capper, D., Sill, M., Buchhalter, I., Northcott, P.A., Leis, I., Ryzhova, M., Koelsche, C., Pfaff, E., Allen, S.J., Balasubramanian, G., Worst, B.C., Pajtler, K.W., Brabetz, S., Johann, P.D., Sahm, F., Reimand, J., Mackay, A., Carvalho, D.M., Remke, M., Phillips, J.J., Perry, A., Cowdrey, C., Drissi, R., Fouladi, M., Giangaspero, F., Lastowska, M., Grajkowska, W., Scheurlen, W., Pietsch, T., Hagel, C., Gojo, J., Lotsch, D., Berger, W., Slavc, I., Haberler, C., Jouvet, A., Holm, S., Hofer, S., Prinz, M., Keohane, C., Fried, I., Mawrin, C., Scheie, D., Mobley, B.C., Schniederjan, M.J., Santi, M., Buccoliero, A.M., Dahiya, S., Kramm, C.M., Bueren, A.O. von, Hoff, K. von, Rutkowski, S., Herold-Mende, C., Fruhwald, M.C., Milde, T., Hasselblatt, M., Wesseling, P., Rossler, J., Schuller, U., Ebinger, M., Schittenhelm, J., Frank, S., Grobholz, R., Vajtai, I., Hans, V., Schneppenheim, R., Zitterbart, K., Collins, V.P., Aronica, E., Varlet, P., Puget, S., Dufour, C., Grill, J., Figarella-Branger, D., Wolter, M., Schuhmann, M.U., Shalaby, T., Grotzer, M., Meter, T. van, Monoranu, C.M., Felsberg, J., Reifenberger, G., Snuderl, M., Forrester, L.A., Koster, J., Versteeg, R., Volckmann, R., Sluis, P. van, Wolf, S., Mikkelsen, T., Gajjar, A., Aldape, K., Moore, A.S., Taylor, M.D., Jones, C., et al., Sturm, D., Orr, B.A., Toprak, U.H., Hovestadt, V., Jones, D.T., Capper, D., Sill, M., Buchhalter, I., Northcott, P.A., Leis, I., Ryzhova, M., Koelsche, C., Pfaff, E., Allen, S.J., Balasubramanian, G., Worst, B.C., Pajtler, K.W., Brabetz, S., Johann, P.D., Sahm, F., Reimand, J., Mackay, A., Carvalho, D.M., Remke, M., Phillips, J.J., Perry, A., Cowdrey, C., Drissi, R., Fouladi, M., Giangaspero, F., Lastowska, M., Grajkowska, W., Scheurlen, W., Pietsch, T., Hagel, C., Gojo, J., Lotsch, D., Berger, W., Slavc, I., Haberler, C., Jouvet, A., Holm, S., Hofer, S., Prinz, M., Keohane, C., Fried, I., Mawrin, C., Scheie, D., Mobley, B.C., Schniederjan, M.J., Santi, M., Buccoliero, A.M., Dahiya, S., Kramm, C.M., Bueren, A.O. von, Hoff, K. von, Rutkowski, S., Herold-Mende, C., Fruhwald, M.C., Milde, T., Hasselblatt, M., Wesseling, P., Rossler, J., Schuller, U., Ebinger, M., Schittenhelm, J., Frank, S., Grobholz, R., Vajtai, I., Hans, V., Schneppenheim, R., Zitterbart, K., Collins, V.P., Aronica, E., Varlet, P., Puget, S., Dufour, C., Grill, J., Figarella-Branger, D., Wolter, M., Schuhmann, M.U., Shalaby, T., Grotzer, M., Meter, T. van, Monoranu, C.M., Felsberg, J., Reifenberger, G., Snuderl, M., Forrester, L.A., Koster, J., Versteeg, R., Volckmann, R., Sluis, P. van, Wolf, S., Mikkelsen, T., Gajjar, A., Aldape, K., Moore, A.S., Taylor, M.D., Jones, C., and et al.

Abstract

Item does not contain fulltext, Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.

Published
2016

10. Characterization of metabolites in infiltrating gliomas using ex vivo &supl;H high-resolution magic angle spinning spectroscopy

Author

Elkhaled, A., Jalbert, L., Constantin, A., Yoshihara, H.A., Phillips, J.J., Molinaro, A.M., Chang, S.M., and Nelson, S.J.

Abstract

Gliomas are routinely graded according to histopathological criteria established by the World Health Organization. Although this classification can be used to understand some of the variance in the clinical outcome of patients, there is still substantial heterogeneity within and between lesions of the same grade. This study evaluated image-guided tissue samples acquired from a large cohort of patients presenting with either new or recurrent gliomas of grades II-IV using ex vivo proton high-resolution magic angle spinning spectroscopy. The quantification of metabolite levels revealed several discrete profiles associated with primary glioma subtypes, as well as secondary subtypes that had undergone transformation to a higher grade at the time of recurrence. Statistical modeling further demonstrated that these metabolomic profiles could be differentially classified with respect to pathological grading and inter-grade conversions. Importantly, the myo-inositol to total choline index allowed for a separation of recurrent low-grade gliomas on different pathological trajectories, the heightened ratio of phosphocholine to glycerophosphocholine uniformly characterized several forms of glioblastoma multiforme, and the onco-metabolite D-2-hydroxyglutarate was shown to help distinguish secondary from primary grade IV glioma, as well as grade II and III from grade IV glioma. These data provide evidence that metabolite levels are of interest in the assessment of both intra-grade and intra-lesional malignancy. Such information could be used to enhance the diagnostic specificity of in vivo spectroscopy and to aid in the selection of the most appropriate therapy for individual patients.

Published
2014

11. Spin and parity measurement of the Lambda(1405) baryon

Author

Moriya, K., Schumacher, R.A., Aghasyan, M., Amaryan, M.J., Anderson, M.D., Anefalos Pereira, S., Ball, J., Baltzell, N.A., Battaglieri, M., Bellis, M., Biselli, A.S., Bono, J., Boiarinov, S., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Carman, D.S., Celentano, A., Chandavar, S., Charles, G., Cole, P.L., Collins, P., Contalbrigo, M., Cortes, O., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Dey, B., Djalali, C., Dugger, M., Dupré, R., Egiyan, H., El Alaoui, A., El Fassi, L., Elouadrhiri, L., Eugenio, P., Fedotov, G., Fegan, S., Fleming, J.A., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Gohn, W., Golovatch, E., Gothe, R.W., Guidal, M., Griffioen, K.A., Hafidi, K., Hakobyan, H., Hicks, K., Holtrop, M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jo, H.S., Joo, K., Keller, D., Khandaker, M., Kim, W., Koirala, S., Kubarovsky, V., Kuleshov, S.V., Lenisa, P., Lu, H.Y., Macgregor, I.J.D., Markov, N., Mccracken, M., Mckinnon, B., Mestayer, M.D., Meyer, C.A., Mirazita, M., Mokeev, V., Montgomery, R.A., Moutarde, H., Munevar, E., Nadel-Turonski, P., Niccolai, S., Niculescu, I., Osipenko, M., Pappalardo, L.L., Pasyuk, E., Peng, P., Phillips, J.J., Pisano, S., Pogorelko, O., Pozdniakov, S., Price, J.W., Procureur, S., Puckett, A.J.R., Raue, B.A., Rimal, D., Ripani, M., Ritchie, B.G., Rizzo, A., Rosner, G., Roy, Pascal, Sabatié, F., Salgado, C., Schott, D., Seder, E., Senderovich, I., Smith, E.S., Sokhan, D., Smith, G.D., Stepanyan, S., Strauch, S., Tang, W., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Weinstein, L.B., Williams, M., Wood, M.H., Zachariou, N., Zana, L., Zhang, J., Ziegler, V., Zhao, Z.W., Zonta, I., Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CLAS, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], FOS: Physical sciences, High Energy Physics::Experiment, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment (nucl-ex), Nuclear Experiment, High Energy Physics - Experiment, Settore FIS/04 - Fisica Nucleare e Subnucleare
Abstract

A determination of the spin and parity of the $\Lambda(1405)$ is presented using photoproduction data from the CLAS detector at Jefferson Lab. The reaction $\gamma + p \to K^+ + \Lambda(1405)$ is analyzed in the decay channel $\Lambda(1405) \to \Sigma^+ + \pi^-$, where the decay distribution to $\Sigma^+ \pi^-$ and the variation of the $\Sigma^+$ polarization with respect to the $\Lambda(1405)$ polarization direction determines the parity. The $\Lambda(1405)$ is produced, in the energy range $2.55 < W < 2.85$ GeV and for $0.6 < \cos \theta_{K^+} < 0.9$, with polarization $P = 0.45 \pm 0.02 (\text{stat}) \pm 0.07 (\text{syst})$. The analysis shows that the decays are in $S$ wave, with the $\Sigma^+$ polarized such that the $\Lambda(1405)$ has spin-parity $J^P = 1/2^-$, as expected by most theories., Comment: 6 pages, 4 figures, accepted by Phys. Rev. Lett

Published
2014
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12. Beam asymmetry Σ for π+ and π0 photoproduction on the proton for photon energies from 1.102 to 1.862 GeV

Author

Dugger, M., Ritchie, B.G., Collins, P., Pasyuk, E., Briscoe, W.J., Strakovsky, I. I., Workman, R.L., Azimov, Y., Adhikari, K.P., Adikaram, D., Aghasyan, M., Amaryan, M.J., Anderson, M.D., Pereira, S., Avakian, H., Ball, J., Baltzell, N.A., Battaglieri, M., Batourine, V., Bedlinskiy, I., Biselli, A.S., Boiarinov, S., Burkert, V.D., Carman, D.S., Celentano, A., Chandavar, S., Cole, P.L., Contalbrigo, M., Cortes, O., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Deur, A., Djalali, C., Doughty, D., Dupre, R., Egiyan, H., El Alaoui, A., El Fassi, L., Eugenio, P., Fedotov, G., Fegan, S., Fleming, J.A., Gevorgyan, N., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Goetz, J.T., Gohn, W., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Hanretty, C., Harrison, N., Heddle, D., Hicks, K., Ho, D., Holtrop, M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jo, H.S., Joo, K., Keller, D., Khandaker, M., Kim, W., Klein, A., Klein, F.J., Koirala, S., Kubarovsky, A., Kubarovsky, V., Kuleshov, S.V., Lewis, S., Livingston, K., Lu, H.Y., MacGregor, I.J.D., Martinez, D., Mayer, M., McKinnon, B., Mineeva, T., Mirazita, M., Mokeev, V., Montgomery, R.A., Moutarde, H., Munevar, E., Camacho, C., Nadel-Turonski, P., Nepali, C.S., Niccolai, S., Niculescu, G., Niculescu, I., Osipenko, M., Ostrovidov, A.I., Pappalardo, L.L., Paremuzyan, R., Park, K., Park, S., Phelps, E., Phillips, J.J., Pisano, S., Pogorelko, O., Pozdniakov, S., Price, J.W., Procureur, S., Prok, Y., Protopopescu, D., Raue, B.A., Rimal, D., Ripani, M., Rosner, G., Rossi, P., Sabatié, F., Saini, M.S., Salgado, C., Schott, D., Schumacher, R.A., Seder, E., Seraydaryan, H., Sharabian, Y.G., Smith, G.D., Sober, D.I., Sokhan, D., Stepanyan, S.S., Stoler, P., Strauch, S., Taiuti, M., Tang, W., Tian, Ye, Tkachenko, S., Torayev, B., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Weygand, D.P., Zachariou, N., Zana, L., Zhang, J., Zhao, Z.W., and Zonta, I.

Subjects
Nuclear Experiment
Abstract

Beam asymmetries for the reactions γp→pπ0 and γp→nπ+ have been measured with the CEBAF Large Acceptance Spectrometer (CLAS) and a tagged, linearly polarized photon beam with energies from 1.102–1.862 GeV. A Fourier moment technique for extracting beam asymmetries from experimental data is described. The results reported here possess greater precision and finer energy resolution than previous measurements. Our data for both pion reactions appear to favor the SAID and Bonn-Gatchina scattering analyses over the older Mainz MAID predictions. After incorporating the present set of beam asymmetries into the world database, exploratory fits made with the SAID analysis indicate that the largest changes from previous fits are for properties of the Δ(1700)3/2− and Δ(1905)5/2+ states.

Published
2013

13. Differential Photoproduction Cross Sections of the Sigma0(1385), Lambda(1405), and Lambda(1520)

Author

Moriya, K., Schumacher, R.A., Adhikari, K.P., Adikaram, D., Aghasyan, M., Amaryan, M.J., Anderson, M.D., Anefalos Pereira, S., Avakian, H., Ball, J., Baltzell, N.A., Battaglieri, M., Batourine, V., Bedlinskiy, I., Bellis, M., Bennett, R.P., Biselli, A.S., Bono, J., Boiarinov, S., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Carman, D.S., Celentano, A., Chandavar, S., Collins, P., Contalbrigo, M., Cortes, O., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., De Sanctis, E., Deur, A., Dey, B., Djalali, C., Doughty, D., Dugger, M., Dupre, R., Egiyan, H., El Fassi, L., Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Fleming, J.A., Gevorgyan, N., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Goetz, J.T., Gohn, W., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guidal, M., Guler, N., Guo, L., Hakobyan, H., Hanretty, C., Heddle, D., Hicks, K., Ho, D., Holtrop, M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jo, H.S., Joo, K., Keller, D., Khandaker, M., Klein, A., Klein, F.J., Koirala, S., Kubarovsky, A., Kubarovsky, V., Kuleshov, S.V., Lewis, S., Livingston, K., Lu, H.Y., Macgregor, I.J.D., Martinez, David, Mayer, M., Mccracken, M., Mckinnon, B., Mestayer, M.D., Meyer, C.A., Mineeva, T., Mirazita, M., Mokeev, V., Montgomery, R.A., Moutarde, H., Munevar, E., Munoz Camacho, C., Nadel-Turonski, P., Nasseripour, R., Nepali, C.S., Niccolai, S., Niculescu, G., Niculescu, I., Osipenko, M., Ostrovidov, A.I., Pappalardo, L.L., Paremuzyan, R., Park, K., Park, S., Pasyuk, E., Phelps, E., Phillips, J.J., Pisano, S., Pogorelko, O., Pozdniakov, S., Price, J.W., Procureur, S., Protopopescu, D., Puckett, A.J.R., Raue, B.A., Rimal, D., Ripani, M., Ritchie, B.G., Rosner, G., Rossi, P., Sabatié, F., Saini, M.S., Salgado, C., Schott, D., Seder, E., Seraydaryan, H., Sharabian, Y.G., Smith, G.D., Sober, D.I., Sokhan, D., Stepanyan, S., Stoler, P., Strauch, S., Taiuti, M., Tang, W., Taylor, C.E., Taylor, S., Tian, Y., Tkachenko, S., Ungaro, M., Vernarsky, B., Vineyard, M.F., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Weinstein, L.B., Williams, M., Wood, M.H., Zachariou, N., Zana, L., Zhang, J., Zhao, Z.W., Zonta, I., Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), CLAS, and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)

Subjects
High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment, High Energy Physics - Experiment
Abstract

We report the exclusive photoproduction cross sections for the Sigma(1385), Lambda(1405), and Lambda(1520) in the reactions gamma + p -> K+ + Y* using the CLAS detector for energies from near the respective production thresholds up to a center-of-mass energy W of 2.85 GeV. The differential cross sections are integrated to give the total exclusive cross sections for each hyperon. Comparisons are made to current theoretical models based on the effective Lagrangian approach and fitted to previous data. The accuracy of these models is seen to vary widely. The cross sections for the Lambda(1405) region are strikingly different for the Sigma+pi-, Sigma0 pi0, and Sigma- pi+ decay channels, indicating the effect of isospin interference, especially at W values close to the threshold., 21 pages, 18 figures, to be submitted to PRC, revised to include a missing reference

Published
2013
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14. Separated Structure Functions for Exclusive $K^+\Lambda$ and $K^+\Sigma^0$ Electroproduction at 5.5 GeV with CLAS

Author

Carman, D.S., Park, K., Raue, B.A., Adhikari, K.P., Adikaram, D., Aghasyan, M., Amaryan, M.J., Anderson, M.D., Anefalos Pereira, S., Anghinolfi, M., Avakian, H., Baghdasaryan, H., Ball, J., Baltzell, N.A., Battaglieri, M., Batourine, V., Bedlinskiy, I., Biselli, A.S., Bono, J., Boiarinov, S., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Celentano, A., Chandavar, S., Charles, G., Cole, P.L., Contalbrigo, M., Cortes, O., Crede, V., d'Angelo, A., Dashyan, N., de Vita, R., de Sanctis, E., Deur, A., Djalali, C., Doughty, D., Dupre, R., El Alaoui, A., El Fassi, L., Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Fleming, J.A., Fradi, A., Gabrielyan, M.Y., Gevorgyan, N., Giovanetti, K.L., Girod, F.X., Goetz, J.T., Gohn, W., Gothe, R.W., Griffioen, K.A., Guegan, B., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Hanretty, C., Harrison, N., Heddle, D., Hicks, K., Ho, D., Holtrop, M., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jo, H.S., Joo, K., Keller, D., Khandaker, M., Khetarpal, P., Kim, A., Kim, W., Klein, A., Klein, F.J., Koirala, S., Kubarovsky, A., Kubarovsky, V., Kuleshov, S.V., Kvaltine, N.D., Lewis, S., Livingston, K., Lu, H.Y., Macgregor, I.J.D., Mao, Y., Martinez, David, Mayer, M., Mckinnon, B., Mestayer, M.D., Meyer, C.A., Mineeva, T., Mirazita, M., Mokeev, V., Montgomery, R.A., Moutarde, H., Munevar, E., Munoz Camacho, C., Nadel-Turonski, P., Nasseripour, R., Nepali, C.S., Niccolai, S., Niculescu, G., Niculescu, I., Osipenko, M., Ostrovidov, A.I., Pappalardo, L.L., Paremuzyan, R., Park, S., Pasyuk, E., Phelps, E., Phillips, J.J., Pisano, S., Pogorelko, O., Pozdniakov, S., Price, J.W., Procureur, S., Prok, Y., Protopopescu, D., Puckett, A.J.R., Ricco, G., Rimal, D., Ripani, M., Rosner, G., Rossi, P., Sabatié, F., Saini, M.S., Salgado, C., Saylor, N.A., Schott, D., Schumacher, R.A., Seder, E., Seraydaryan, H., Sharabian, Y.G., Smith, G.D., Sober, D.I., Sokhan, D., Stepanyan, S.S., Stepanyan, S., Stoler, P., Strakovsky, I.I., Strauch, S., Taiuti, M., Tang, W., Taylor, C.E., Tian, Y., Tkachenko, S., Trivedi, A., Ungaro, M., Vernarsky, B., Voskanyan, H., Voutier, E., Walford, N.K., Weinstein, L.B., Wood, M.H., Zachariou, N., Zana, L., Zhang, J., Zhao, Z.W., Zonta, I., Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CLAS, and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment, High Energy Physics - Experiment
Abstract

We report measurements of the exclusive electroproduction of $K^+\Lambda$ and $K^+\Sigma^0$ final states from an unpolarized proton target using the CLAS detector at the Thomas Jefferson National Accelerator Facility. The separated structure functions $\sigma_U$, $\sigma_{LT}$, $\sigma_{TT}$, and $\sigma_{LT'}$ were extracted from the $\Phi$-dependent differential cross sections acquired with a longitudinally polarized 5.499 GeV electron beam. The data span a broad range of momentum transfers $Q^2$ from 1.4 to 3.9 GeV$^2$, invariant energy $W$ from threshold to 2.6 GeV, and nearly the full center-of-mass angular range of the kaon. The separated structure functions provide an unprecedented data sample, which in conjunction with other meson photo- and electroproduction data, will help to constrain the higher-level analyses being performed to search for missing baryon resonances., Comment: 27 pages, 23 figures

Published
2013
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15. Cross sections for the $\gamma p \to K^{*+} \Lambda$ and $\gamma p \to K^{*+} \Sigma^{0}$ reactions measured at CLAS

Author

Tang, W., Hicks, K., Keller, D., H. Kim, S., C. Kim, H., Adhikari, K.P., Aghasyan, M., Amaryan, M.J., Anderson, M.D., Anefalos Pereira, S., Baltzell, N.A., Battaglieri, M., Bedlinskiy, I., Biselli, A.S., Bono, J., Boiarinov, S., Briscoe, W.J., Burkert, V.D., Carman, D.S., Celentano, A., Chandavar, S., Charles, G., Collins, P., Contalbrigo, M., Cortes, O., Crede, V., d'Angelo, A., Dashyan, N., de Vita, R., de Sanctis, E., Deur, A., Djalali, C., Doughty, D., Dupre, R., El Alaoui, A., El Fassi, L., Eugenio, P., Fedotov, G., Fegan, S., Fleming, J.A., Gabrielyan, M.Y., Gevorgyan, N., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Gohn, W., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guidal, M., Guo, L., Hafidi, K., Hakobyan, H., Hanretty, C., Harrison, N., Heddle, D., Ho, D., Holtrop, M., Hyde, C. E., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jo, H.S., Joo, K., Khandaker, M., Khetarpal, P., Kim, A., Kim, W., Klein, F.J., Koirala, S., Kubarovsky, A., Kubarovsky, V., Kuleshov, S.V., Livingston, K., Lu, H.Y., Macgregor, I..J .D., Mao, Y., Markov, N., Martinez, David, Mayer, M., Mckinnon, B., Meyer, C.A., Mokeev, V., Moutarde, H., Munevar, E., Muñoz, C., Nadel-Turonski, P., Nepali, C.S., Niccolai, S., Niculescu, G., Niculescu, I., Osipenko, M., Ostrovidov, A.I., Pappalardo, L.L., Paremuzyan, R., Park, K., Park, S., Pasyuk, E., Phelps, E., Phillips, J.J., Pisano, S., Pogorelko, O., Pozdniakov, S., Price, J.W., Procureur, S., Prok, Y., Protopopescu, D., Puckett, A.J.R., Raue, B.A., Ripani, M., Rimal, D., Ritchie, B.G., Rosner, G., Rossi, P., Sabatié, F., Saini, M.S., Salgado, C., Schott, D., Schumacher, R.A., Seraydaryan, H., Sharabian, Y.G., Smith, G.D., Sober, D.I., Sokhan, D., Stepanyan, S.S., Stepanyan, S., Stoler, P., Strakovsky, I.I., Strauch, S., Taylor, C.E., Tian, Ye, Tkachenko, S., Torayev, B., Ungaro, M., Vernarsky, B., Vlassov, A.V., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Weinstein, L.B., Weygand, D.P., Wood, M.H., Zachariou, N., Zana, L., Zhang, J., Zhao, Z.W., Zonta, I., Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CLAS, and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
High Energy Physics::Experiment, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment
Abstract

The first high-statistics cross sections for the reactions $\gamma p \to K^{*+} \Lambda$ and $\gamma p \to K^{*+} \Sigma^0$ were measured using the CLAS detector at photon energies between threshold and 3.9 GeV at the Thomas Jefferson National Accelerator Facility. Differential cross sections are presented over the full range of the center-of-mass angles, $\theta^{CM}_{K^{*+}}$, and then fitted to Legendre polynomials to extract the total cross section. Results for the $K^{*+}\Lambda$ final state are compared with two different calculations in an isobar and a Regge model, respectively. Theoretical calculations significantly underestimate the $K^{*+} \Lambda$ total cross sections between 2.1 and 2.6 GeV, but are in better agreement with present data at higher photon energies., Comment: 15 pages, 24 figures

Published
2013
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16. Measurement of the Sigma pi photoproduction line shapes near the Lambda(1405)

Author

Moriya, K., Schumacher, R.A., Adhikari, K.P., Adikaram, D., Aghasyan, M., Anderson, M.D., Anefalos Pereira, S., Ball, J., Baltzell, N.A., Battaglieri, M., Batourine, V., Bedlinskiy, I., Bellis, M., Biselli, A.S., Bono, J., Boiarinov, S., Briscoe, W.J., Burkert, V.D., Carman, D.S., Celentano, A., Chandavar, S., Charles, G., Cole, P.L., Collins, P., Crede, V., D'Angelo, A., Dashyan, N., De Sanctis, E., De Vita, R., Deur, A., Dey, B., Djalali, C., Doughty, D., Dupre, R., Egiyan, H., El Fassi, L., Eugenio, P., Fedotov, G., Fegan, S., Fersch, R., Fleming, J.A., Gevorgyan, N., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Goetz, J.T., Gohn, W., Golovatch, E., Gothe, R.W., Griffioen, K.A., Guidal, M., Hafidi, K., Hakobyan, H., Hanretty, C., Harrison, N., Heddle, D., Hicks, K., Ho, D., Holtrop, M., Hyde, C. E., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Jo, H.S., Keller, D., Khandaker, M., Khetarpal, P., Kim, A., Kim, W., Klein, A., Klein, F.J., Koirala, S., Kubarovsky, A., Kubarovsky, V., Kuleshov, S.V., Kvaltine, N.D., Livingston, K., Lu, H.Y., Macgregor, I.J.D., Markov, N., Mayer, M., Mccracken, M., Mckinnon, B., Mestayer, M.D., Meyer, C.A., Mirazita, M., Mineeva, T., Mokeev, V., Montgomery, R.A., Munevar, E., Munoz Camacho, C., Nadel-Turonski, P., Nasseripour, R., Nepali, C.S., Niccolai, S., Niculescu, G., Niculescu, I., Osipenko, M., Ostrovidov, A.I., Pappalardo, L.L., Paremuzyan, R., Park, K., Park, S., Pasyuk, E., Phelps, E., Phillips, J.J., Pisano, S., Pivnyuk, N., Pogorelko, O., Pozdniakov, S., Price, J.W., Procureur, S., Protopopescu, D., Rimal, D., Ripani, M., Ritchie, B.G., Rosner, G., Rossi, P., Sabatié, F., Saini, M.S., Salgado, C., Schott, D., Seder, E., Seraydaryan, H., Sharabian, Y.G., Smith, E.S., Smith, G.D., Sober, D.I., Stepanyan, S.S., Stepanyan, S., Stoler, P., Strakovsky, I.I., Strauch, S., Taiuti, M., Tang, W., Taylor, S., Taylor, C.E., Tian, Ye, Tkachenko, S., Torayev, B., Ungaro, M., Vernarsky, B., Vlassov, A.V., Voskanyan, H., Voutier, E., Walford, N.K., Watts, D.P., Weygand, D.P., Williams, M., Zachariou, N., Zana, L., Zhang, J., Zhao, Z.W., Zonta, I., Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CLAS, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
BARYONS, KAON-NUCLEON INTERACTIONS, CHIRAL DYNAMICS, QUARK-MODEL, RESONANCES, STATES, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Settore FIS/04 - Fisica Nucleare e Subnucleare, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

The reaction gamma + p -> K+ + Sigma + pi was used to determine the invariant mass distributions or "line shapes" of the Sigma+ pi-, Sigma- pi+ and Sigma0 pi0 final states, from threshold at 1328 MeV/c^2 through the mass range of the Lambda(1405) and the Lambda(1520). The measurements were made with the CLAS system at Jefferson Lab using tagged real photons, for center-of-mass energies 1.95 < W < 2.85 GeV. The three mass distributions differ strongly in the vicinity of the I=0 ��(1405), indicating the presence of substantial I=1 strength in the reaction. Background contributions to the data from the Sigma0(1385) and from K^* Sigma production were studied and shown to have negligible influence. To separate the isospin amplitudes, Breit-Wigner model fits were made that included channel-coupling distortions due to the NKbar threshold. A best fit to all the data was obtained after including a phenomenological I=1, J^P = 1/2^- amplitude with a centroid at 1394\pm20 MeV/c^2 and a second I=1 amplitude at 1413\pm10 MeV/c^2. The centroid of the I=0 Lambda(1405) strength was found at the Sigma pi threshold, with the observed shape determined largely by channel-coupling, leading to an apparent overall peak near 1405 MeV/c^2., Figure got replaced during submission, fixed

Published
2013
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17. DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors

Author

Mazor, T. (Tali), Pankov, A. (Aleksandr), Johnson, B.E. (Brett E.), Hong, C. (Chibo), Hamilton, E.G. (Emily G.), Bell, R.J.A. (Robert J.A.), Smirnov, I.V. (Ivan V.), Reis, G.F. (Gerald F.), Phillips, J.J. (Joanna J.), Barnes, M.J. (Michael), Idbaih, A. (Ahmed), Alentorn, A. (Agusti), Kloezeman, J.J. (Jenneke), Lamfers, M.L.M. (Martine), Bollen, A.W. (Andrew W.), Taylor, B.S. (Barry S.), Molinaro, A.M. (Annette M.), Olshen, A. (Adam), Chang, S.M. (Susan), Song, J.S. (Jun S.), Costello, J.F. (Joseph F.), Mazor, T. (Tali), Pankov, A. (Aleksandr), Johnson, B.E. (Brett E.), Hong, C. (Chibo), Hamilton, E.G. (Emily G.), Bell, R.J.A. (Robert J.A.), Smirnov, I.V. (Ivan V.), Reis, G.F. (Gerald F.), Phillips, J.J. (Joanna J.), Barnes, M.J. (Michael), Idbaih, A. (Ahmed), Alentorn, A. (Agusti), Kloezeman, J.J. (Jenneke), Lamfers, M.L.M. (Martine), Bollen, A.W. (Andrew W.), Taylor, B.S. (Barry S.), Molinaro, A.M. (Annette M.), Olshen, A. (Adam), Chang, S.M. (Susan), Song, J.S. (Jun S.), and Costello, J.F. (Joseph F.)

Abstract

The evolutionary history of tumor cell populations can be reconstructed from patterns of genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and sensitive to the microenvironment, prompting the question whether epigenetic information can similarly be used to discover tumor phylogeny. We examined the spatial and temporal dynamics of DNA methylation in a cohort of low-grade gliomas and their patient-matched recurrences. Genes transcriptionally upregulated through promoter hypomethylation during malignant progression to high-grade glioblastoma were enriched in cell cycle function, evolving in parallel with genetic alterations that deregulate the G1/S cell cycle checkpoint. Moreover, phyloepigenetic relationships robustly recapitulated phylogenetic patterns inferred from somatic mutations. These findings highlight widespread co-dependency of genetic and epigenetic events throughout brain tumor evolution.

Published
2015
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18. FGFR1 ligand complex

Author

Klein, T., primary, Vajpai, N., additional, Phillips, J.J., additional, Davies, G., additional, Holdgate, G.A., additional, Phillips, C., additional, Tucker, J.A., additional, Norman, R.A., additional, Scott, A.S., additional, Higazi, D.R., additional, Lowe, D., additional, Thompson, G.S., additional, and Breeze, A.L., additional

Published
2015
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19. FGFR1 in complex with dovitinib

Author

Klein, T., primary, Vajpai, N., additional, Phillips, J.J., additional, Davies, G., additional, Holdgate, G.A., additional, Phillips, C., additional, Tucker, J.A., additional, Norman, R.A., additional, Scott, A.S., additional, Higazi, D.R., additional, Lowe, D., additional, Thompson, G.S., additional, and Breeze, A.L., additional

Published
2015
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21. Measurement of transparency ratios for protons from short-range correlated pairs

Author

Hen, O., primary, Hakobyan, H., additional, Shneor, R., additional, Piasetzky, E., additional, Weinstein, L.B., additional, Brooks, W.K., additional, May-Tal Beck, S., additional, Gilad, S., additional, Korover, I., additional, Beck, A., additional, Adhikari, K.P., additional, Aghasyan, M., additional, Amaryan, M.J., additional, Anefalos Pereira, S., additional, Arrington, J.R., additional, Baghdasaryan, H., additional, Ball, J., additional, Battaglieri, M., additional, Batourine, V., additional, Bedlinskiy, I., additional, Biselli, A.S., additional, Bono, J., additional, Boiarinov, S., additional, Briscoe, W.J., additional, Burkert, V.D., additional, Carman, D.S., additional, Celentano, A., additional, Chandavar, S., additional, Cole, P.L., additional, Contalbrigo, M., additional, Crede, V., additional, DʼAngelo, A., additional, Dashyan, N., additional, De Vita, R., additional, De Sanctis, E., additional, Deur, A., additional, Djalali, C., additional, Dodge, G.E., additional, Doughty, D., additional, Dupre, R., additional, Egiyan, H., additional, El Alaoui, A., additional, El Fassi, L., additional, Eugenio, P., additional, Fedotov, G., additional, Fegan, S., additional, Fleming, J.A., additional, Gabrielyan, M.Y., additional, Gevorgyan, N., additional, Gilfoyle, G.P., additional, Giovanetti, K.L., additional, Girod, F.X., additional, Goetz, J.T., additional, Gohn, W., additional, Golovatch, E., additional, Gothe, R.W., additional, Griffioen, K.A., additional, Guo, L., additional, Hafidi, K., additional, Harrison, N., additional, Heddle, D., additional, Hicks, K., additional, Holtrop, M., additional, Hyde, C.E., additional, Ilieva, Y., additional, Ireland, D.G., additional, Ishkhanov, B.S., additional, Isupov, E.L., additional, Jo, H.S., additional, Joo, K., additional, Keller, D., additional, Khandaker, M., additional, Khetarpal, P., additional, Kim, A., additional, Klein, F.J., additional, Koirala, S., additional, Kubarovsky, A., additional, Kubarovsky, V., additional, Kuhn, S.E., additional, Livingston, K., additional, Lu, H.Y., additional, MacGregor, I.J.D., additional, Martinez, D., additional, Mayer, M., additional, McKinnon, B., additional, Mineeva, T., additional, Mokeev, V., additional, Montgomery, R.A., additional, Moutarde, H., additional, Munevar, E., additional, Munoz Camacho, C., additional, Mustapha, B., additional, Nadel-Turonski, P., additional, Nasseripour, R., additional, Niccolai, S., additional, Niculescu, G., additional, Niculescu, I., additional, Osipenko, M., additional, Ostrovidov, A.I., additional, Pappalardo, L.L., additional, Paremuzyan, R., additional, Park, K., additional, Park, S., additional, Pasyuk, E., additional, Phelps, E., additional, Phillips, J.J., additional, Pisano, S., additional, Pivnyuk, N., additional, Pogorelko, O., additional, Pozdniakov, S., additional, Price, J.W., additional, Procureur, S., additional, Protopopescu, D., additional, Puckett, A.J.R., additional, Raue, B.A., additional, Rimal, D., additional, Ripani, M., additional, Ritchie, B.G., additional, Rosner, G., additional, Rossi, P., additional, Sabatié, F., additional, Saini, M.S., additional, Schott, D., additional, Schumacher, R.A., additional, Seraydaryan, H., additional, Sharabian, Y.G., additional, Smith, G.D., additional, Sober, D.I., additional, Sokhan, D., additional, Stepanyan, S.S., additional, Stepanyan, S., additional, Strauch, S., additional, Taiuti, M., additional, Tang, W., additional, Taylor, C.E., additional, Tian, Ye, additional, Tkachenko, S., additional, Ungaro, M., additional, Vernarsky, B., additional, Vlassov, A., additional, Voskanyan, H., additional, Voutier, E., additional, Walford, N.K., additional, Watts, D.P., additional, Wood, M.H., additional, Zachariou, N., additional, Zana, L., additional, Zhang, J., additional, Zheng, X., additional, and Zonta, I., additional

Published
2013
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25. How to Keep from Getting Burned on an Outside Seminar

Author

Phillips, J.J.

Subjects
Offices, Business, Business, general, Human resources and labor relations
Abstract

A few simple guidelines will assist management in determining which business seminars it should have its employees participate in. A manager should not be misled by an impressive brochure. A complete brochure should contain detailed information concerning the leaders and speakers, the agenda, the method(s) of instruction and the target audience. A manager should contact the seminar sponsor if additional information is required. A manger might want to speak with previous participants of the seminar. Finally, management should look into the learning environment of a seminar, and the methods of instruction. Handout materials should be provided participants for later perusal. A conference center equipped for presentations provides a better environment than a hotel. A manger should be wary of a seminar organizer who is unwilling to provide any of this information.

Published
1983

29. INDUSTRY-TRAINED GRADUATES-YES OR NO?

Author

PHILLIPS, J.J.

Subjects
Human resource management -- Training, Education -- Management, Business, Human resources and labor relations
Published
1979

35. MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Author

Stéphanie Puget, Mariarita Santi, Daniel C. Bowers, Cynthia Hawkins, Rosemary E. Henn, Laura M. Urbanski, Jeremiah Wala, Mélanie Pagès, Azra H. Ligon, Anna Maria Buccoliero, Peleg M. Horowitz, Phillip B. Storm, Mirko Scagnet, Liliana Goumnerova, Matthew D. Ducar, Kristine Pelton, Pascale Varlet, Uri Tabori, Sabine Mueller, Pratiti Bandopadhayay, Yun Jee Kang, Rameen Beroukhim, Joanna J. Phillips, Adam C. Resnick, Payal Jain, Brenton R. Paolella, László Bognár, Mark W. Kieran, David S. Knoff, Yuankun Zhu, Rhamy Zeid, Shakti Ramkissoon, Charles G. Eberhart, Hayley Malkin, Adam Tracy, Katie Boucher, Amanda Silva, Lori A. Ramkissoon, Adrianne Gladden-Young, Keith L. Ligon, Nada Jabado, Jacques Grill, Daphne A. Haas-Kogan, Sandro Santagata, James E. Bradner, Charles D. Stiles, Alexander J. Federation, Harry J. Han, Almos Klekner, Angela J. Waanders, Sara Seepo, Ryan O’Rourke, Paul Van Hummelen, Namrata Choudhari, D. Ashley Hill, Fausto J. Rodriguez, Caterina Giannini, William J. Gibson, Alon Goren, Peter C. Burger, Guillaume Bergthold, Steven E. Schumacher, Bandopadhayay P., Ramkissoon L.A., Jain P., Bergthold G., Wala J., Zeid R., Schumacher S.E., Urbanski L., O'Rourke R., Gibson W.J., Pelton K., Ramkissoon S.H., Han H.J., Zhu Y., Choudhari N., Silva A., Boucher K., Henn R.E., Kang Y.J., Knoff D., Paolella B.R., Gladden-Young A., Varlet P., Pages M., Horowitz P.M., Federation A., Malkin H., Tracy A.A., Seepo S., Ducar M., Van Hummelen P., Santi M., Buccoliero A.M., Scagnet M., Bowers D.C., Giannini C., Puget S., Hawkins C., Tabori U., Klekner A., Bognar L., Burger P.C., Eberhart C., Rodriguez F.J., Hill D.A., Mueller S., Haas-Kogan D.A., Phillips J.J., Santagata S., Stiles C.D., Bradner J.E., Jabado N., Goren A., Grill J., Ligon A.H., Goumnerova L., Waanders A.J., Storm P.B., Kieran M.W., Ligon K.L., Beroukhim R., and Resnick A.C.

Subjects
0301 basic medicine, Oncogene Proteins, Fusion, Carcinogenesis, Angiocentric Glioma, Biology, medicine.disease_cause, Article, Oncogene Proteins v-myb, 03 medical and health sciences, Glioma, Cell Line, Tumor, Genetics, medicine, Humans, MYB, Exome, Epigenetics, Child, Carcinogenesi, Gene Rearrangement, Mutation, Comparative Genomic Hybridization, High-Throughput Nucleotide Sequencing, RNA-Binding Proteins, Gene rearrangement, medicine.disease, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Cancer research, Human
Abstract

Angiocentric gliomas are pediatric low-grade gliomas (PLGGs) without known recurrent genetic drivers. We performed genomic analysis of new and published data from 249 PLGGs, including 19 angiocentric gliomas. We identified MYB-QKI fusions as a specific and single candidate driver event in angiocentric gliomas. In vitro and in vivo functional studies show that MYB-QKI rearrangements promote tumorigenesis through three mechanisms: MYB activation by truncation, enhancer translocation driving aberrant MYB-QKI expression and hemizygous loss of the tumor suppressor QKI. To our knowledge, this represents the first example of a single driver rearrangement simultaneously transforming cells via three genetic and epigenetic mechanisms in a tumor.

Published
2016

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