679,215 results on '"Phillips A."'
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2. Weathering the Storm: The Educational Impacts of Hurricane Harvey. Research Brief
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Rice University, Houston Education Research Consortium (HERC), Southern Methodist University (SMU), Simmons School of Education and Human Development, Meredith P. Richards, Cheyenne Phillips, Alexandra E. Pavlakis, and J. Kessa Roberts
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In August 2017, Hurricane Harvey ravaged the Houston area, causing the homelessness of nearly 24,000 students in the Houston Independent School District (Houston ISD) alone. Additionally, nearly all Houston ISD schools sustained damage of some kind, resulting in school closures, campus relocations, and even the delaying of the start of classes for some students. In the first brief of this two-part series, the authors examine the characteristics of students who became homeless due to Harvey. They found that students who became temporarily homeless for a year or less due to Harvey tended to fare as well as or better on educational outcomes than even their never-homeless peers.
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- 2024
3. Weathering the Storm: Hurricane Harvey and Student Housing Instability
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Rice University, Houston Education Research Consortium (HERC), Southern Methodist University (SMU), Simmons School of Education and Human Development, Meredith P. Richards, Cheyenne Phillips, Alexandra E. Pavlakis, and J. Kessa Roberts
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In August 2017, the Houston area was ravaged by one of the costliest natural disasters in history--Hurricane Harvey. In this brief, the first in a two-part series, the authors examine the effects of Harvey on student homelessness in the Houston Independent School District (Houston ISD). The authors find that student homelessness in Houston ISD quadrupled due to Harvey, and most students experiencing homelessness lived, at least temporarily, in unsheltered contexts, such as sleeping in a car or on the street. Unlike other high-profile storms such as Hurricane Katrina, students who became homeless due to Harvey tended to be broadly representative of the district in terms of their demographic characteristics. However, they differed systematically from students who experienced homelessness for conventional, economic reasons such as job loss and medical debt, who were particularly likely to be Black. The authors conclude with implications of these findings for educational stakeholders in preparation for both generational and "everyday" homelessness crises.
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- 2024
4. Spillover Effects of Specialized High Schools. EdWorkingPaper No. 24-1013
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Annenberg Institute for School Reform at Brown University, Christine Mulhern, Shelby McNeill, Fatih Unlu, Brian Phillips, Julie A. Edmunds, and Eric Grebing
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Specialized high schools are an increasingly popular way to prepare young adults for postsecondary experiences and expand school choice. While much literature ex- amines charter school spillover effects and the effects of specialized schools on the students who attend them, little is known about the spillover effects of specialized high schools on traditional public schools (TPS). Using an event study design, we show that one type of specialized high school, North Carolina's Cooperative Innovative High Schools, initially attracted students who were higher achieving and more likely to be white than TPS students, but these specialized schools became more representative of the district population over time. On average, the opening of specialized schools had a mix of null and positive spillover effects on TPS student achievement. While there is some evidence of negative spillovers from the first schools that opened, the effects become more positive over time.
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- 2024
5. Transitioning Adolescents to Adult HIV Care in the United States: Implementation lessons from the 'iTransition' Intervention Pilot Trial
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Tanner, Amanda E, Mertus, Sulianie, Eldin Jibriel, Mohammed Sheikh, Urquhart, Rakira, Phillips, Keenan, Dowshen, Nadia, Dutta, Srija, Goldstein, Madeleine H, Lee, Susan, Knowles, Kayla, Darien, Kaja, Rulison, Kelly L, Madden, Julia, and Hussen, Sophia A
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- 2024
6. Three-dimensional Structure of Incomplete Carbon-Oxygen Detonations in Type Ia Supernovae
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Khokhlov, A., Dominguez, I., Chtchelkanova, A. Y., Hoeflich, P., Baron, E., Krisciunas, K., Phillips, M., Suntzeff, N., and Wang, L.
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Astrophysics - Solar and Stellar Astrophysics ,Physics - Plasma Physics - Abstract
Carbon-oxygen (CO) detonation with reactions terminating either after burning of C$^{12}$ in the leading C$^{12}$ + C$^{12}$ reaction or after burning of C$^{12}$ and O$^{16}$ to Si-group elements may occur in the low-density outer layers of exploding white dwarfs and be responsible for the production of intermediate-mass elements observed in the outer layers of Type Ia supernovae. Basic one-dimensional properties of CO-detonations have been summarized in our previous work. This paper presents the results of two- and three-dimensional numerical simulations of low-density CO-detonations and discusses their multidimensional stability, cellular structure, and propagation through a constant low-density background. We find three-dimensional CO detonations to be strikingly different from their one-dimensional and two-dimensional counterparts. Three-dimensional detonations are significantly more robust and capable of propagating without decay compared to highly unstable and marginal one- and two- dimensional detonations. The detonation cell size and whether burning of C$^{12}$ in a three-dimensional detonation wave is followed by the subsequent O$^{16}$ burning is sensitive to both the background density and the initial C$^{12}$ to O$^{16}$ mass ratio. We also discuss the possible implications for understanding the observed early time bumps in light-curves., Comment: 29 pages, 15 Figures; ApJ, submitted (11/26/2024), revised (1/14/2025), accepted(1/25/2025), in press
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- 2025
7. Arithmetic functions on a Dedekind domain
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Phillips, Andrew
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Mathematics - Number Theory ,11A25 - Abstract
We study functions on the set of all integral ideals in a Dedekind domain. The set of all such functions is a commutative ring isomorphic to a ring of formal power series in infinitely many variables. The set of all totally multiplicative functions has a ringed space structure, which, after identifying functions with the same prime ideal zeros, determines the Dedekind domain up to isomorphism., Comment: 21 pages
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- 2025
8. Humanity's Last Exam
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Phan, Long, Gatti, Alice, Han, Ziwen, Li, Nathaniel, Hu, Josephina, Zhang, Hugh, Shi, Sean, Choi, Michael, Agrawal, Anish, Chopra, Arnav, Khoja, Adam, Kim, Ryan, Hausenloy, Jason, Zhang, Oliver, Mazeika, Mantas, Anderson, Daron, Nguyen, Tung, Mahmood, Mobeen, Feng, Fiona, Feng, Steven Y., Zhao, Haoran, Yu, Michael, Gangal, Varun, Zou, Chelsea, Wang, Zihan, Wang, Jessica P., Kumar, Pawan, Pokutnyi, Oleksandr, Gerbicz, Robert, Popov, Serguei, Levin, John-Clark, Kazakov, Mstyslav, Schmitt, Johannes, Galgon, Geoff, Sanchez, Alvaro, Lee, Yongki, Yeadon, Will, Sauers, Scott, Roth, Marc, Agu, Chidozie, Riis, Søren, Giska, Fabian, Utpala, Saiteja, Giboney, Zachary, Goshu, Gashaw M., Xavier, Joan of Arc, Crowson, Sarah-Jane, Naiya, Mohinder Maheshbhai, Burns, Noah, Finke, Lennart, Cheng, Zerui, Park, Hyunwoo, Fournier-Facio, Francesco, Wydallis, John, Nandor, Mark, Singh, Ankit, Gehrunger, Tim, Cai, Jiaqi, McCarty, Ben, Duclosel, Darling, Nam, Jungbae, Zampese, Jennifer, Hoerr, Ryan G., Bacho, Aras, Loume, Gautier Abou, Galal, Abdallah, Cao, Hangrui, Garretson, Alexis C, Sileo, Damien, Ren, Qiuyu, Cojoc, Doru, Arkhipov, Pavel, Qazi, Usman, Li, Lianghui, Motwani, Sumeet, de Witt, Christian Schroeder, Taylor, Edwin, Veith, Johannes, Singer, Eric, Hartman, Taylor D., Rissone, Paolo, Jin, Jaehyeok, Shi, Jack Wei Lun, Willcocks, Chris G., Robinson, Joshua, Mikov, Aleksandar, Prabhu, Ameya, Tang, Longke, Alapont, Xavier, Uro, Justine Leon, Zhou, Kevin, Santos, Emily de Oliveira, Maksimov, Andrey Pupasov, Vendrow, Edward, Zenitani, Kengo, Guillod, Julien, Li, Yuqi, Vendrow, Joshua, Kuchkin, Vladyslav, Ze-An, Ng, Marion, Pierre, Efremov, Denis, Lynch, Jayson, Liang, Kaiqu, Gritsevskiy, Andrew, Martinez, Dakotah, Pageler, Ben, Crispino, Nick, Zvonkine, Dimitri, Fraga, Natanael Wildner, Soori, Saeed, Press, Ori, Tang, Henry, Salazar, Julian, Green, Sean R., Brüssel, Lina, Twayana, Moon, Dieuleveut, Aymeric, Rogers, T. Ryan, Zhang, Wenjin, Li, Bikun, Yang, Jinzhou, Rao, Arun, Loiseau, Gabriel, Kalinin, Mikhail, Lukas, Marco, Manolescu, Ciprian, Mishra, Subrata, Kamdoum, Ariel Ghislain Kemogne, Kreiman, Tobias, Hogg, Tad, Jin, Alvin, Bosio, Carlo, Sun, Gongbo, Coppola, Brian P, Tarver, Tim, Heidinger, Haline, Sayous, Rafael, Ivanov, Stefan, Cavanagh, Joseph M, Shen, Jiawei, Imperial, Joseph Marvin, Schwaller, Philippe, Senthilkuma, Shaipranesh, Bran, Andres M, Dehghan, Ali, Algaba, Andres, Verbeken, Brecht, Noever, David, P V, Ragavendran, Schut, Lisa, Sucholutsky, Ilia, Zheltonozhskii, Evgenii, Lim, Derek, Stanley, Richard, Sivarajan, Shankar, Yang, Tong, Maar, John, Wykowski, Julian, Oller, Martí, Sandlin, Jennifer, Sahu, Anmol, Hu, Yuzheng, Fish, Sara, Heydari, Nasser, Apronti, Archimedes, Rawal, Kaivalya, Vilchis, Tobias Garcia, Zu, Yuexuan, Lackner, Martin, Koppel, James, Nguyen, Jeremy, Antonenko, Daniil S., Chern, Steffi, Zhao, Bingchen, Arsene, Pierrot, Goldfarb, Alan, Ivanov, Sergey, Poświata, Rafał, Wang, Chenguang, Li, Daofeng, Crisostomi, Donato, Achilleos, Andrea, Myklebust, Benjamin, Sen, Archan, Perrella, David, Kaparov, Nurdin, Inlow, Mark H, Zang, Allen, Thornley, Elliott, Orel, Daniil, Poritski, Vladislav, Ben-David, Shalev, Berger, Zachary, Whitfill, Parker, Foster, Michael, Munro, Daniel, Ho, Linh, Hava, Dan Bar, Kuchkin, Aleksey, Lauff, Robert, Holmes, David, Sommerhage, Frank, Schneider, Keith, Kazibwe, Zakayo, Stambaugh, Nate, Singh, Mukhwinder, Magoulas, Ilias, Clarke, Don, Kim, Dae Hyun, Dias, Felipe Meneguitti, Elser, Veit, Agarwal, Kanu Priya, Vilchis, Victor Efren Guadarrama, Klose, Immo, Demian, Christoph, Anantheswaran, Ujjwala, Zweiger, Adam, Albani, Guglielmo, Li, Jeffery, Daans, Nicolas, Radionov, Maksim, Rozhoň, Václav, Ma, Ziqiao, Stump, Christian, Berkani, Mohammed, Platnick, Jacob, Nevirkovets, Volodymyr, Basler, Luke, Piccardo, Marco, Jeanplong, Ferenc, Cohen, Niv, Tkadlec, Josef, Rosu, Paul, Padlewski, Piotr, Barzowski, Stanislaw, Montgomery, Kyle, Menezes, Aline, Patel, Arkil, Wang, Zixuan, Tucker-Foltz, Jamie, Stade, Jack, Goertzen, Tom, Kazemi, Fereshteh, Milbauer, Jeremiah, Ambay, John Arnold, Shukla, Abhishek, Labrador, Yan Carlos Leyva, Givré, Alan, Wolff, Hew, Rossbach, Vivien, Aziz, Muhammad Fayez, Kaddar, Younesse, Chen, Yanxu, Zhang, Robin, Pan, Jiayi, Terpin, Antonio, Muennighoff, Niklas, Schoelkopf, Hailey, Zheng, Eric, Carmi, Avishy, Jones, Adam, Shah, Jainam, Brown, Ethan D. L., Zhu, Kelin, Bartolo, Max, Wheeler, Richard, Ho, Andrew, Barkan, Shaul, Wang, Jiaqi, Stehberger, Martin, Kretov, Egor, Sridhar, Kaustubh, EL-Wasif, Zienab, Zhang, Anji, Pyda, Daniel, Tam, Joanna, Cunningham, David M., Goryachev, Vladimir, Patramanis, Demosthenes, Krause, Michael, Redenti, Andrew, Bugas, Daniel, Aldous, David, Lai, Jesyin, Coleman, Shannon, Bahaloo, Mohsen, Xu, Jiangnan, Lee, Sangwon, Zhao, Sandy, Tang, Ning, Cohen, Michael K., Carroll, Micah, Paradise, Orr, Kirchner, Jan Hendrik, Steinerberger, Stefan, Ovchynnikov, Maksym, Matos, Jason O., Shenoy, Adithya, Junior, Benedito Alves de Oliveira, Wang, Michael, Nie, Yuzhou, Giordano, Paolo, Petersen, Philipp, Sztyber-Betley, Anna, Shukla, Priti, Crozier, Jonathan, Pinto, Antonella, Verma, Shreyas, Joshi, Prashant, Yong, Zheng-Xin, Tee, Allison, Andréoletti, Jérémy, Weller, Orion, Singhal, Raghav, Zhang, Gang, Ivanov, Alexander, Khoury, Seri, Mostaghimi, Hamid, Thaman, Kunvar, Chen, Qijia, Khánh, Tran Quoc, Loader, Jacob, Cavalleri, Stefano, Szlyk, Hannah, Brown, Zachary, Roberts, Jonathan, Alley, William, Sun, Kunyang, Stendall, Ryan, Lamparth, Max, Reuel, Anka, Wang, Ting, Xu, Hanmeng, Raparthi, Sreenivas Goud, Hernández-Cámara, Pablo, Martin, Freddie, Malishev, Dmitry, Preu, Thomas, Korbak, Tomek, Abramovitch, Marcus, Williamson, Dominic, Chen, Ziye, Bálint, Biró, Bari, M Saiful, Kassani, Peyman, Wang, Zihao, Ansarinejad, Behzad, Goswami, Laxman Prasad, Sun, Yewen, Elgnainy, Hossam, Tordera, Daniel, Balabanian, George, Anderson, Earth, Kvistad, Lynna, Moyano, Alejandro José, Maheshwari, Rajat, Sakor, Ahmad, Eron, Murat, McAlister, Isaac C., Gimenez, Javier, Enyekwe, Innocent, O., Andrew Favre D., Shah, Shailesh, Zhou, Xiaoxiang, Kamalov, Firuz, Clark, Ronald, Abdoli, Sherwin, Santens, Tim, Meer, Khalida, Wang, Harrison K, Ramakrishnan, Kalyan, Chen, Evan, Tomasiello, Alessandro, De Luca, G. Bruno, Looi, Shi-Zhuo, Le, Vinh-Kha, Kolt, Noam, Mündler, Niels, Semler, Avi, Rodman, Emma, Drori, Jacob, Fossum, Carl J, Jagota, Milind, Pradeep, Ronak, Fan, Honglu, Shah, Tej, Eicher, Jonathan, Chen, Michael, Thaman, Kushal, Merrill, William, Harris, Carter, Gross, Jason, Gusev, Ilya, Sharma, Asankhaya, Agnihotri, Shashank, Zhelnov, Pavel, Usawasutsakorn, Siranut, Mofayezi, Mohammadreza, Bogdanov, Sergei, Piperski, Alexander, Carauleanu, Marc, Zhang, David K., Ler, Dylan, Leventov, Roman, Soroko, Ignat, Jansen, Thorben, Lauer, Pascal, Duersch, Joshua, Taamazyan, Vage, Morak, Wiktor, Ma, Wenjie, Held, William, Huy, Tran Đuc, Xian, Ruicheng, Zebaze, Armel Randy, Mohamed, Mohanad, Leser, Julian Noah, Yuan, Michelle X, Yacar, Laila, Lengler, Johannes, Shahrtash, Hossein, Oliveira, Edson, Jackson, Joseph W., Gonzalez, Daniel Espinosa, Zou, Andy, Chidambaram, Muthu, Manik, Timothy, Haffenden, Hector, Stander, Dashiell, Dasouqi, Ali, Shen, Alexander, Duc, Emilien, Golshani, Bita, Stap, David, Uzhou, Mikalai, Zhidkovskaya, Alina Borisovna, Lewark, Lukas, Vincze, Mátyás, Wehr, Dustin, Tang, Colin, Hossain, Zaki, Phillips, Shaun, Muzhen, Jiang, Ekström, Fredrik, Hammon, Angela, Patel, Oam, Remy, Nicolas, Farhidi, Faraz, Medley, George, Mohammadzadeh, Forough, Peñaflor, Madellene, Kassahun, Haile, Friedrich, Alena, Sparrow, Claire, Sakal, Taom, Dhamane, Omkar, Mirabadi, Ali Khajegili, Hallman, Eric, Battaglia, Mike, Maghsoudimehrabani, Mohammad, Hoang, Hieu, Amit, Alon, Hulbert, Dave, Pereira, Roberto, Weber, Simon, Mensah, Stephen, Andre, Nathan, Peristyy, Anton, Harjadi, Chris, Gupta, Himanshu, Malina, Stephen, Albanie, Samuel, Cai, Will, Mehkary, Mustafa, Reidegeld, Frank, Dick, Anna-Katharina, Friday, Cary, Sidhu, Jasdeep, Kim, Wanyoung, Costa, Mariana, Gurdogan, Hubeyb, Weber, Brian, Kumar, Harsh, Jiang, Tong, Agarwal, Arunim, Ceconello, Chiara, Vaz, Warren S., Zhuang, Chao, Park, Haon, Tawfeek, Andrew R., Aggarwal, Daattavya, Kirchhof, Michael, Dai, Linjie, Kim, Evan, Ferret, Johan, Wang, Yuzhou, Yan, Minghao, Burdzy, Krzysztof, Zhang, Lixin, Franca, Antonio, Pham, Diana T., Loh, Kang Yong, Gul, Shreen, Chhablani, Gunjan, Du, Zhehang, Cosma, Adrian, White, Colin, Riblet, Robin, Saxena, Prajvi, Votava, Jacob, Vinnikov, Vladimir, Delaney, Ethan, Halasyamani, Shiv, Shahid, Syed M., Mourrat, Jean-Christophe, Vetoshkin, Lavr, Bacho, Renas, Ginis, Vincent, Maksapetyan, Aleksandr, de la Rosa, Florencia, Li, Xiuyu, Malod, Guillaume, Lang, Leon, Laurendeau, Julien, Adesanya, Fatimah, Portier, Julien, Hollom, Lawrence, Souza, Victor, Zhou, Yuchen Anna, Yalın, Yiğit, Obikoya, Gbenga Daniel, Arnaboldi, Luca, Rai, Bigi, Filippo, Bacho, Kaniuar, Clavier, Pierre, Recchia, Gabriel, Popescu, Mara, Shulga, Nikita, Tanwie, Ngefor Mildred, Lux, Thomas C. H., Rank, Ben, Ni, Colin, Yakimchyk, Alesia, Huanxu, Liu, Häggström, Olle, Verkama, Emil, Narayan, Himanshu, Gundlach, Hans, Brito-Santana, Leonor, Amaro, Brian, Vajipey, Vivek, Grover, Rynaa, Fan, Yiyang, Silva, Gabriel Poesia Reis e, Xin, Linwei, Kratish, Yosi, Łucki, Jakub, Li, Wen-Ding, Xu, Justin, Scaria, Kevin Joseph, Vargus, Freddie, Habibi, Farzad, Long, Lian, Rodolà, Emanuele, Robins, Jules, Cheng, Vincent, Grabb, Declan, Bosio, Ida, Fruhauff, Tony, Akov, Ido, Lo, Eve J. Y., Qi, Hao, Jiang, Xi, Segev, Ben, Fan, Jingxuan, Martinson, Sarah, Wang, Erik Y., Hausknecht, Kaylie, Brenner, Michael P., Mao, Mao, Jiang, Yibo, Zhang, Xinyu, Avagian, David, Scipio, Eshawn Jessica, Siddiqi, Muhammad Rehan, Ragoler, Alon, Tan, Justin, Patil, Deepakkumar, Plecnik, Rebeka, Kirtland, Aaron, Montecillo, Roselynn Grace, Durand, Stephane, Bodur, Omer Faruk, Adoul, Zahra, Zekry, Mohamed, Douville, Guillaume, Karakoc, Ali, Santos, Tania C. B., Shamseldeen, Samir, Karim, Loukmane, Liakhovitskaia, Anna, Resman, Nate, Farina, Nicholas, Gonzalez, Juan Carlos, Maayan, Gabe, Hoback, Sarah, Pena, Rodrigo De Oliveira, Sherman, Glen, Mariji, Hodjat, Pouriamanesh, Rasoul, Wu, Wentao, Demir, Gözdenur, Mendoza, Sandra, Alarab, Ismail, Cole, Joshua, Ferreira, Danyelle, Johnson, Bryan, Milliron, Hsiaoyun, Safdari, Mohammad, Dai, Liangti, Arthornthurasuk, Siriphan, Pronin, Alexey, Fan, Jing, Ramirez-Trinidad, Angel, Cartwright, Ashley, Pottmaier, Daphiny, Taheri, Omid, Outevsky, David, Stepanic, Stanley, Perry, Samuel, Askew, Luke, Rodríguez, Raúl Adrián Huerta, Dendane, Abdelkader, Ali, Sam, Lorena, Ricardo, Iyer, Krishnamurthy, Salauddin, Sk Md, Islam, Murat, Gonzalez, Juan, Ducey, Josh, Campbell, Russell, Somrak, Maja, Mavroudis, Vasilios, Vergo, Eric, Qin, Juehang, Borbás, Benjámin, Chu, Eric, Lindsey, Jack, Radhakrishnan, Anil, Jallon, Antoine, McInnis, I. M. J., Hoover, Alex, Möller, Sören, Bian, Song, Lai, John, Patwardhan, Tejal, Yue, Summer, Wang, Alexandr, and Hendrycks, Dan
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
Benchmarks are important tools for tracking the rapid advancements in large language model (LLM) capabilities. However, benchmarks are not keeping pace in difficulty: LLMs now achieve over 90\% accuracy on popular benchmarks like MMLU, limiting informed measurement of state-of-the-art LLM capabilities. In response, we introduce Humanity's Last Exam (HLE), a multi-modal benchmark at the frontier of human knowledge, designed to be the final closed-ended academic benchmark of its kind with broad subject coverage. HLE consists of 3,000 questions across dozens of subjects, including mathematics, humanities, and the natural sciences. HLE is developed globally by subject-matter experts and consists of multiple-choice and short-answer questions suitable for automated grading. Each question has a known solution that is unambiguous and easily verifiable, but cannot be quickly answered via internet retrieval. State-of-the-art LLMs demonstrate low accuracy and calibration on HLE, highlighting a significant gap between current LLM capabilities and the expert human frontier on closed-ended academic questions. To inform research and policymaking upon a clear understanding of model capabilities, we publicly release HLE at https://lastexam.ai., Comment: 25 pages, 6 figures
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- 2025
9. Self-configuring high-speed multi-plane light conversion
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Rocha, José C. A., Būtaitė, Unė G., Carpenter, Joel, and Phillips, David B.
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Physics - Optics ,Physics - Applied Physics - Abstract
Multi-plane light converters (MPLCs) - also known as linear diffractive neural networks - are an emerging optical technology, capable of converting an orthogonal set of optical fields into any other orthogonal set via a unitary transformation. MPLC design is a non-linear problem typically solved by optimising a digital model of the optical system. However, inherently high levels of design complexity mean that even a minor mismatch between this digital model and the physically realised MPLC leads to a severe reduction in real-world performance. Here we address this challenge by creating a self-configuring free-space MPLC. Despite the large number of parameters to be optimised (typically tens of thousands or more), our proof-of-principle device converges in minutes using a method in which light only needs to be transmitted in one direction through the MPLC. Two innovations make this possible. Firstly, we devise an in-situ optimisation algorithm combining wavefront shaping with the principles of wavefront matching that would conventionally be used to inverse-design MPLCs offline in simulation. Secondly, we introduce a new MPLC platform incorporating a microelectromechanical system (MEMS) phase-only light modulator - allowing rapid MPLC switching at up to kiloHertz rates. Our scheme automatically accounts for the physical characteristics of all system components and absorbs any unknown misalignments and aberrations into the final design. We demonstrate self-configured MPLCs capable of mapping random orthogonal speckle input fields to well-defined Laguerre-Gaussian and Hermite-Gaussian output modes, as well as universal mode sorters. Our work paves the way towards large-scale ultra-high-fidelity fast-switching MPLCs and diffractive neural networks, which promises to unlock new applications in areas ranging from optical communications to optical computing and imaging., Comment: 14 pages, 7 figures, 1 table
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- 2025
10. HD 206893 B at High Spectral Resolution with the Keck Planet Imager and Characterizer (KPIC)
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Sappey, Ben, Konopacky, Quinn, O, Clarissa R. Do, Barman, Travis, Ruffio, Jean-Baptiste, Wang, Jason, Theissen, Christopher A., Finnerty, Luke, Xuan, Jerry, Hortsman, Katelyn, Mawet, Dimitri, Zhang, Yapeng, Inglis, Julie, Wallack, Nicole L., Sanghi, Aniket, Baker, Ashley, Bartos, Randall, Blake, Geoffrey A., Bond, Charlotte Z., Calvin, Benjamin, Cetre, Sylvain, Delorme, Jacques-Robert, Doppmann, Greg, Echeverri, Daniel, Fitzgerald, Michael P., Hsu, Chih-Chun, Jovanovic, Nemanja, Liberman, Joshua, Lopez, Ronald A., Martin, Emily C., Morris, Evan, Pezzato-Rovner, Jacklyn, Phillips, Caprice L., Ruane, Garreth, Schofield, Tobias, Skemer, Andrew, Venenciano, Taylor, Wallace, J. Kent, Wang, Ji, Wizinowich, Peter, and Xin, Yinzi
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present an atmospheric characterization and orbital analysis of HD 206893 B, an exceptionally red, L/T-transition substellar companion in a multiplanetary system, via Keck Planet Imager and Characterizer (KPIC) high-resolution (R $\sim$ 35,000) K-band spectroscopy. Using PHOENIX atmospheric models in a forward-model framework that fits the spectrum of the companion and diffracted starlight simultaneously, we detect HD 206893 B at $>8\sigma$ significance via cross-correlation in two epochs. We find an effective temperature for the companion of $1634^{+72}_{-38}$ K and a log(g) of $4.55^{+0.17}_{-0.22}$. Only accounting for statistical uncertainties, we measure the carbon-oxygen ratio (C/O) of this companion to be $0.57 \pm 0.02$, or near-solar while assuming solar metallicity. The C/O ratio we measure fits the tentative trend of $>4 M_{Jup}$ companions having near-solar C/O ratios while less massive companions have greater-than-solar C/O ratios. Using substellar evolution models, we find an age of $112^{+36}_{-22}$ Myr, a mass of $22.7^{+2.5}_{-1.7} M_{Jup}$, and a radius of $1.11 \pm 0.03 R_{Jup}$ for this companion. We also use KPIC radial velocity data to fit the orbit of HD 206893 B and analyze the orbital stability of this system. We find that the orbital stability is relatively independent of the mass of HD 206893 B, and favors an orbital configuration where B and its interior planetary companion, HD 206893 c, are co-planar. The measured C/O ratio coupled with the current architecture of the system cannot rule out a core accretion scenario, nor a disk fragmentation scenario regarding the formation pathway of HD 206893 B., Comment: 37 pages, 23 figures
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- 2025
11. Time-Constrained Model Predictive Control for Autonomous Satellite Rendezvous, Proximity Operations, and Docking
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Behrendt, Gabriel, Hale, Matthew, Soderlund, Alexander, Phillips, Sean, and Kain, Evan
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Electrical Engineering and Systems Science - Systems and Control - Abstract
This paper presents a time-constrained model predictive control strategy for the six degree-of-freedom autonomous rendezvous, proximity, operations and docking problem between a controllable "deputy" satellite and an uncontrolled "chief" satellite. The objective is to achieve a docking configuration defined by both the translational and attitudinal states of the deputy relative to the chief, whose dynamics are respectively governed by both the Clohessy-Wiltshire equations and Euler's second law of motion. The proposed control strategy explicitly addresses computational time constraints that are common to state-of-the-art space vehicles. Thus, a time-constrained model predictive control strategy is implemented on a space-grade processor. Although suboptimal with regards to energy consumption when compared to conventional optimal RPO trajectories, it is empirically demonstrated via numerical simulations that the deputy spacecraft still achieves a successful docking configuration while subject to computational time constraints., Comment: arXiv admin note: text overlap with arXiv:2211.11653
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- 2025
12. Self-aligned multilayered nitrogen vacancy diamond nanoparticles for high spatial resolution magnetometry of microelectronic currents
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Gokhale, Yash, Coventry, Brandon S, Rogers, Tsani, Lines, Maya, Vena, Anna, Phillips, Jack, Zhu, Tianxiang, Bok, Ilhan, Troche, Dariana J., Glodowski, Mitchell, Vareberg, Adam, Bhatt, Suyash, Ashtiani, Alireza, Eliceiri, Kevin W., and Hai, Aviad
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Instrumentation and Detectors - Abstract
Nitrogen Vacancy diamond nanoparticles (NVNPs) are increasingly integrated with methods for optical detection of magnetic resonance (ODMR), providing new opportunities in magnetic characterization that span the visualization of magnetic fields in microelectronic circuits, environmental sensing and biology. However, only a small number of studies utilize aggregates of NVNPs for surface-wide magnetometry being that spin orientations in aggregate NVNPs are inherently misaligned, precluding their use for proper magnetic field detection compared with expensive monocrystalline diamonds. A postprocessing method for layering NVNPs with aligned NV center orientations can potentially facilitate superior NV magnetometry by allowing sensitive detection combined with simplified probe preparation. We present a novel technology for creating densely stacked monolayers of NVNP with inherent interlayer alignment for sensitive measurement of local magnetic field perturbations in microelectronic traces. We establish spatial characteristics of deposited aggregates and demonstrate their ability to capture magnetic dipoles from conducting microwires via ODMR. Our approach forms a novel accessible protocol that can be used for broad applications in micromagnetometry.
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- 2025
13. REBELS-IFU: Dust Build-up in Massive Galaxies at Redshift 7
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Algera, Hiddo, Rowland, Lucie, Stefanon, Mauro, Palla, Marco, Sommovigo, Laura, Inami, Hanae, Bouwens, Rychard, Aravena, Manuel, Bowler, Rebecca, Dayal, Pratika, De Looze, Ilse, Ferrara, Andrea, Fisher, Rebecca, Graziani, Luca, Gulis, Cindy, Heintz, Kasper, Hodge, Jacqueline, van Leeuwen, Ivana, Pallottini, Andrea, Phillips, Siân, Schouws, Sander, Smit, Renske, Stark, Daniel, and van der Werf, Paul
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Astrophysics - Astrophysics of Galaxies - Abstract
In recent years, observations with the JWST have started to map out the rapid metal enrichment of the early Universe, while (sub)millimeter observations have simultaneously begun to reveal the ubiquity of dust beyond $z\gtrsim6$. However, the pathways that led to the assembly of early dust reservoirs remain poorly quantified, and require pushing our understanding of key scaling relations between dust, gas and metals into the early Universe. We investigate the dust build-up in twelve $6.5 \lesssim z \lesssim 7.7$ galaxies drawn from the REBELS survey that benefit from (i) JWST/NIRSpec strong-line metallicity measurements, (ii) ALMA [CII]-based redshifts and gas masses, and (iii) dust masses from single- or multi-band ALMA continuum observations. Combining these measurements, we investigate the dust-to-gas (DtG), dust-to-metal (DtM), and dust-to-stellar mass (DtS) ratios of our sample as a function of metallicity. While our analysis is limited by systematic uncertainties related to the [CII]-to-H$_2$ conversion factor and dust temperature, we explore a wide range of possible values, and carefully assess their impact on our results. Under a fiducial set of assumptions, we find an average $\log(\mathrm{DtG}) = -3.02 \pm 0.23$, only slightly below that of local metal-rich galaxies. On the other hand, at fixed metallicity our average $\log(\mathrm{DtS}) = -2.15 \pm 0.42$ is significantly larger than that of low-redshift galaxies. Finally, through a comparison to various theoretical models of high-redshift dust production, we find that assembling the dust reservoirs in massive galaxies at $z\approx7$ likely requires the combination of rapid supernova enrichment and efficient ISM dust growth., Comment: 18 pages + appendices, 5 figures in main text, submitted to MNRAS
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- 2025
14. REBELS-IFU: Dust attenuation curves of 12 massive galaxies at $z\simeq7$
- Author
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Fisher, Rebecca, Bowler, Rebecca A. A., Stefanon, Mauro, Rowland, Lucie E., Algera, Hiddo S. B., Aravena, Manuel, Bouwens, Rychard, Dayal, Pratika, Ferrara, Andrea, Fudamoto, Yoshinobu, Hodge, Jacqueline A., Inami, Hanae, Ormerod, Katherine, Pallottini, Andrea, Phillips, Siân G., Sartorio, Nina S., Smit, Renske, Sommovigo, Laura, Stark, Dan P., and van der Werf, Paul P.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present measurements of the dust attenuation curves of 12 massive ($9~<~\log$($M_{\star}/{M}_{\odot})$ $<~10$) Lyman-break galaxies at $z=6.5-7.7$ derived from James Webb Space Telescope (JWST) NIRSpec integral field unit (IFU) spectroscopy. The galaxies are drawn from the Atacama Large Millimeter/submillimeter Array (ALMA) Reionization Era Bright Emission Line Survey (REBELS) large program. The dust attenuation curves were obtained by fitting spectral energy distribution (SED) models with a flexible dust law to the full galaxy spectra over observed wavelengths $0.6-5.3$ $\mu$m. These attenuation curves show a range of recovered slopes ($-0.39\leq\delta\leq0.08$) that are on average slightly flatter than seen in local sources of the same stellar masses, with none exhibiting very steep slopes. Three galaxies exhibit evidence for a 2175 \r{A} dust bump ($>4\sigma$) and we find SED fitting excluding the bump can overestimate derived stellar masses by up to $0.4$ dex. Correcting for the dust attenuation with our best-fit attenuation curves we recover a range of intrinsic UV-slopes ($-2.5\leq\beta_0\leq-2.2$). The galaxies show moderate reddening ($A_V~=~0.1-0.6$ mag) and the $A_V$ to stellar mass relation is consistent with local sources. The attenuation law slope is found to correlate with $A_V$, while we see no strong correlation with stellar mass, ${M_{\rm UV}}$, or gas-phase metallicity. Overall, our results show little evolution in dust properties in the REBELS sources compared to the local Universe. Comparing our recovered trends to empirical models suggests that the most important factor driving the variation in the attenuation curves in our sample is the dust-star geometry, not the properties of the dust grains themselves., Comment: 17 Pages, 6 Figures, Submitted to MNRAS
- Published
- 2025
15. Order-by-order uncertainties of nucleon-nucleon Wolfenstein amplitudes in chiral effective field theory
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McClung, B., Elster, Ch., and Phillips, D. R.
- Subjects
Nuclear Theory ,Nuclear Experiment - Abstract
Quantum mechanical invariance principles dictate the most general operator structure that can be present in the nucleon-nucleon (NN) interaction. Five independent operators appear in the on-shell NN amplitude together with five corresponding coefficient functions. The usual choice for these coefficient functions is known as the NN Wolfenstein amplitudes. We analyze the order-by-order convergence of each of the five NN Wolfenstein amplitudes predicted by a semi-local coordinate space potential implementation of chiral effective field theory ($\chi$EFT). We do this at laboratory kinetic energies between 25 and 200 MeV for both neutron-proton and proton-proton scattering. Our analysis uses the Gaussian-Process methods developed by the BUQEYE collaboration to describe the contributions of each $\chi$EFT order, and so yields truncation uncertainties for each Wolfenstein amplitude that are correlated across scattering angles. We combine information on the size of different orders in the EFT to infer the $\chi$EFT breakdown scale for each amplitude, finding, on average, $\Lambda_b$ between 750 and 800 MeV. With this choice of $\Lambda_b$, the EFT truncation uncertainties cover both higher-order results and empirical Wolfenstein amplitudes well for all orders other than the leading order., Comment: 16 pages, 22 figures
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- 2025
16. The Safe Trusted Autonomy for Responsible Space Program
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Hobbs, Kerianne L., Phillips, Sean, Simon, Michelle, Lyons, Joseph B., Culbertson, Jared, Clouse, Hamilton Scott, Hamilton, Nathaniel, Dunlap, Kyle, Lippay, Zachary S., Aurand, Joshua, Bell, Zachary I., Hammack, Taleri, Ayres, Dorothy, and Lim, Rizza
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Electrical Engineering and Systems Science - Systems and Control - Abstract
The Safe Trusted Autonomy for Responsible Space (STARS) program aims to advance autonomy technologies for space by leveraging machine learning technologies while mitigating barriers to trust, such as uncertainty, opaqueness, brittleness, and inflexibility. This paper presents the achievements and lessons learned from the STARS program in integrating reinforcement learning-based multi-satellite control, run time assurance approaches, and flexible human-autonomy teaming interfaces, into a new integrated testing environment for collaborative autonomous satellite systems. The primary results describe analysis of the reinforcement learning multi-satellite control and run time assurance algorithms. These algorithms are integrated into a prototype human-autonomy interface using best practices from human-autonomy trust literature, however detailed analysis of the effectiveness is left to future work. References are provided with additional detailed results of individual experiments.
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- 2025
17. Quantum undetected optical projection tomography
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Gemmell, Nathan R., Pearce, Emma, Florez, Jefferson, Oulton, Rupert F., Clark, Alex S., and Phillips, Chris C.
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Quantum Physics ,Physics - Instrumentation and Detectors ,Physics - Optics - Abstract
Quantum imaging with undetected photons (QIUP) is an emerging technique that decouples the processes of illuminating an object and projecting its image. The properties of the illuminating and detected light can thus be simultaneously optimised for both contrast on a sample and sensitivity on a camera. Here, we combine QIUP with computed tomography to enable three-dimensional (3D) infrared imaging. The image data is registered with a standard silicon camera at a wavelength of 810 nm, but the extracted 3D images map the sample's absorption at a wavelength of 1550 nm, well beyond the camera's sensitivity. Quantum Undetected Optical Projection Tomography (QUOPT) enables label-free volumetric sensing at difficult to detect wavelengths, such as those that allow molecular imaging contrast, or those within the infrared biological transmission windows.
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- 2025
18. Expanding the parameter space of 2002es-like type Ia supernovae: on the underluminous ASASSN-20jq / SN 2020qxp
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Bose, Subhash, Stritzinger, Maximilian D., Ashall, Chris, Baron, Eddie, Hoeflich, Peter, Galbany, L., Hoogendam, W. B., Jensen, E. A. M., Kochanek, C. S., Post, R. S., Reguitti, A., Elias-Rosa, N., Stanek, K. Z., Lundqvist, Peter, Auchettl, Katie, Clocchiatti, Alejandro, Fiore, A., Gutiérrez, Claudia P., Hinkle, Jason T., Huber, Mark E., de Jaeger, T., Pastorello, Andrea, Payne, Anna V., Phillips, Mark, Shappee, Benjamin J., and Tucker, Michael A.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present optical photometric and spectroscopic observations of the peculiar Type Ia supernova ASASSN-20jq/SN 2020qxp. It is a low-luminosity object with a peak absolute magnitude of $M_B=-17.1\pm0.5$ mag. Despite its low luminosity, its post-peak light-curve decline rate ($\Delta m_{15}(B)=1.35\pm0.09$ mag) and color-stretch parameter (sBV>0.82) are similar to normal SNe Ia, making it an outlier in the luminosity-width and luminosity-color-stretch relations. Early light curves suggest a "bump" during the first 1.4 days of explosion. ASASSN-20jq synthesized a low radioactive $^{56}$Ni mass of $0.09\pm0.01M_\odot$. Near-maximum light spectra reveal strong Si II absorption lines, indicating a cooler photosphere than normal SNe Ia, but lack Ti II absorption lines. Unusually strong O I $\lambda$7773 and Ca II near-infrared triplet absorption features are present. Nebular spectra show a strong, narrow forbidden [Ca II] $\lambda\lambda$7291,7324 doublet emission, rarely seen in SNe Ia except in some Type Iax events. Marginal detection of [O I] $\lambda\lambda$6300,6364 doublet emission, which is extremely rare, is observed. Both [Ca II] and [O I] lines are redshifted by $\sim2000$ km/s. A strong [Fe II] $\lambda$7155 emission line with a tilted-top profile, identical to the [Fe II] $\lambda$16433 profile, is also observed. These asymmetric [Fe II] profiles and redshifted [Ca II] and [O I] emissions suggest a high central density white dwarf progenitor undergoing an off-center delayed-detonation explosion mechanism, producing roughly equal amounts of $^{56}$Ni in deflagration and detonation phases. This distinguishes ASASSN-20jq from normal and subluminous SNe Ia. ASASSN-20jq's light curve and spectra do not align with any single SNe Ia subclass but show similarities to 2002es-like objects. Thus, we add it as an extreme candidate within the heterogeneous parameter space of 2002es-like SNe Ia., Comment: 27 pages, 20 figures, 5 tables, submitted to A&A
- Published
- 2025
19. Collaborative Spacecraft Servicing under Partial Feedback using Lyapunov-based Deep Neural Networks
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Nino, Cristian F., Patil, Omkar Sudhir, Petersen, Christopher D., Phillips, Sean, and Dixon, Warren E.
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Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control - Abstract
Multi-agent systems are increasingly applied in space missions, including distributed space systems, resilient constellations, and autonomous rendezvous and docking operations. A critical emerging application is collaborative spacecraft servicing, which encompasses on-orbit maintenance, space debris removal, and swarm-based satellite repositioning. These missions involve servicing spacecraft interacting with malfunctioning or defunct spacecraft under challenging conditions, such as limited state information, measurement inaccuracies, and erratic target behaviors. Existing approaches often rely on assumptions of full state knowledge or single-integrator dynamics, which are impractical for real-world applications involving second-order spacecraft dynamics. This work addresses these challenges by developing a distributed state estimation and tracking framework that requires only relative position measurements and operates under partial state information. A novel $\rho$-filter is introduced to reconstruct unknown states using locally available information, and a Lyapunov-based deep neural network adaptive controller is developed that adaptively compensates for uncertainties stemming from unknown spacecraft dynamics. To ensure the collaborative spacecraft regulation problem is well-posed, a trackability condition is defined. A Lyapunov-based stability analysis is provided to ensure exponential convergence of errors in state estimation and spacecraft regulation to a neighborhood of the origin under the trackability condition. The developed method eliminates the need for expensive velocity sensors or extensive pre-training, offering a practical and robust solution for spacecraft servicing in complex, dynamic environments., Comment: 24 pages, 4 Figures, Journal
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- 2025
20. Femtosecond temperature measurements of laser-shocked copper deduced from the intensity of the x-ray thermal diffuse scattering
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Wark, J. S., Peake, D. J., Stevens, T., Heighway, P. G., Ping, Y., Sterne, P., Albertazzi, B., Ali, S. J., Antonelli, L., Armstrong, M. R., Baehtz, C., Ball, O. B., Banerjee, S., Belonoshko, A. B., Bolme, C. A., Bouffetier, V., Briggs, R., Buakor, K., Butcher, T., Cafiso, S. Di Dio, Cerantola, V., Chantel, J., Di Cicco, A., Coleman, A. L., Collier, J., Collins, G., Comley, A. J., Coppari, F., Cowan, T. E., Cristoforetti, G., Cynn, H., Descamps, A., Dorchies, F., Duff, M. J., Dwivedi, A., Edwards, C., Eggert, J. H., Errandonea, D., Fiquet, G., Galtier, E., Garcia, A. Laso, Ginestet, H., Gizzi, L., Gleason, A., Goede, S., Gonzalez, J. M., Gorman, M. G., Harmand, M., Hartley, N., Hernandez-Gomez, C., Higginbotham, A., Höppner, H., Humphries, O. S., Husband, R. J., Hutchinson, T. M., Hwang, H., Keen, D. A., Kim, J., Koester, P., Konopkova, Z., Kraus, D., Krygier, A., Labate, L., Lazicki, A. E., Lee, Y., Liermann, H-P., Mason, P., Masruri, M., Massani, B., McBride, E. E., McGuire, C., McHardy, J. D., McGonegle, D., McWilliams, R. S., Merkel, S., Morard, G., Nagler, B., Nakatsutsumi, M., Nguyen-Cong, K., Norton, A-M., Oleynik, I. I., Otzen, C., Ozaki, N., Pandolfi, S., Pelka, A., Pereira, K. A., Phillips, J. P., Prescher, C., Preston, T., Randolph, L., Ranjan, D., Ravasio, A., Redmer, R., Rips, J., Santamaria-Perez, D., Savage, D. J., Schoelmerich, M., Schwinkendorf, J-P., Singh, S., Smith, J., Smith, R. F., Sollier, A., Spear, J., Spindloe, C., Stevenson, M., Strohm, C., Suer, T-A., Tang, M., Toncian, M., Toncian, T., Tracy, S. J., Trapananti, A., Tschentscher, T., Tyldesley, M., Vennari, C. E., Vinci, T., Vogel, S. C., Volz, T. J., Vorberger, J., Willman, J. T., Wollenweber, L., Zastrau, U., Brambrink, E., Appel, K., and McMahon, M. I.
- Subjects
Condensed Matter - Materials Science ,Physics - Applied Physics - Abstract
We present 50-fs, single-shot measurements of the x-ray thermal diffuse scattering (TDS) from copper foils that have been shocked via nanosecond laser-ablation up to pressures above 135~GPa. We hence deduce the x-ray Debye-Waller (DW) factor, providing a temperature measurement. The targets were laser-shocked with the DiPOLE 100-X laser at the High Energy Density (HED) endstation of the European X-ray Free-Electron Laser (EuXFEL). Single x-ray pulses, with a photon energy of 18 keV, were scattered from the samples and recorded on Varex detectors. Despite the targets being highly textured (as evinced by large variations in the elastic scattering), and with such texture changing upon compression, the absolute intensity of the azimuthally averaged inelastic TDS between the Bragg peaks is largely insensitive to these changes, and, allowing for both Compton scattering and the low-level scattering from a sacrificial ablator layer, provides a reliable measurement of $T/\Theta_D^2$, where $\Theta_D$ is the Debye temperature. We compare our results with the predictions of the SESAME 3336 and LEOS 290 equations of state for copper, and find good agreement within experimental errors. We thus demonstrate that single-shot temperature measurements of dynamically compressed materials can be made via thermal diffuse scattering of XFEL radation., Comment: 17 pages, 9 figures in main article; 10 pages, 5 figures in supplementary material
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- 2025
21. Efficient Langevin sampling with position-dependent diffusion
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Bronasco, Eugen, Leimkuhler, Benedict, Phillips, Dominic, and Vilmart, Gilles
- Subjects
Mathematics - Numerical Analysis ,60H35, 37M25, 65L06, 41A58, 05C05 - Abstract
We introduce a numerical method for Brownian dynamics with position dependent diffusion tensor which is second order accurate for sampling the invariant measure while requiring only one force evaluation per timestep. Analysis of the sampling bias is performed using the algebraic framework of exotic aromatic Butcher-series. Numerical experiments confirm the theoretical order of convergence and illustrate the efficiency of the new method., Comment: 31 pages
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- 2025
22. An ab initio description of the family of Cr selenides: structure, magnetism and electronic structure from bulk to the single-layer limit
- Author
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Phillips, Jan, Fumega, Adolfo O., Blanco-Canosa, S., and Pardo, Victor
- Subjects
Condensed Matter - Materials Science - Abstract
Compounds based on Cr have been found to be among the first single-layer magnets. In addition, transition metal dichalcogenides are promising candidates to show long-range ferromagnetic order down to the two-dimensional limit. We use ab initio calculations to provide a description of the various Cr$_x$Se$_{x+1}$ stoichiometries that may occur by analyzing from the bulk materials to the monolayer limit. We study the different structural distortions, including charge density waves that each system can present by analyzing their phonon spectra and dynamic stability. We provide a description of their basic electronic structure and study their magnetic properties, including the magnetocrystalline anisotropy energy. The evolution of all these properties with the dimensionality of the systems is discussed. This intends to be a comprehensive view of the broad family of Cr selenides.
- Published
- 2024
23. Quantum Fisher Information Reveals UV-IR Mixing in the Strange Metal
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Bałut, David, Guo, Xuefei, de Vries, Niels, Chaudhuri, Dipanjan, Bradlyn, Barry, Abbamonte, Peter, and Phillips, Philip W.
- Subjects
Condensed Matter - Strongly Correlated Electrons ,High Energy Physics - Theory ,Quantum Physics - Abstract
The density-density response in optimally doped Bi$_2$Sr$_2$CaCu$_2$O$_{8+x}$ has recently been shown to exhibit conformal symmetry. Using, the experimentally inferred conformal dynamic susceptibility, we compute the resultant quantum Fisher information (QFI), a witness to multi-partite entanglement. In contrast to a Fermi liquid in which the QFI is approximately temperature independent much below the Fermi energy scale, we find that the QFI increases as a power law at low temperatures but ultimately extrapolates to a constant at $T=0$. The constant is of the form, $\omega_g^{2\Delta}$, where $\Delta$ is the conformal dimension and $\omega_g$ is the UV cutoff which is on the order of the pseudogap. As this constant {depends on both UV and IR properties}, it illustrates that multipartite entanglement in a strange metal exhibits UV-IR mixing, a benchmark feature of doped Mott insulators as exemplified by dynamical spectral weight transfer. We conclude with a discussion of the implication of our results for low-energy reductions of the Hubbard model., Comment: For an issue of Physica C dedicated to Jan Zaanen
- Published
- 2024
24. Towards a (meta-)mathematical theory of consciousness: universal (mapping) properties of experience
- Author
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Phillips, Steven and Tsuchiya, Naotsugu
- Subjects
Quantitative Biology - Neurons and Cognition - Abstract
Conscious (subjective) experience permeates our daily lives, yet general consensus on a theory of consciousness remains elusive. Integrated Information Theory (IIT) is a prominent approach that asserts the existence of subjective experience (0th axiom), from an intrinsic system of causally related units, and five essential properties (axioms 1-5): intrinsicality, information, integration, exclusion and composition. However, despite empirical support for some aspects of IIT, the supposed necessity of these axioms is unclear given their informal presentation and operationalized dependence on a specific mathematical instantiation as the so-called postulates. The category theory approach presented here attempts to redress this situation. Category theory is a kind of meta-mathematics invented to make relations between formal structures formally precise and so facilitate doing "ordinary" mathematics. In this way, the five essential properties for consciousness are organized around a smaller number of meta-mathematical principles for comparison with IIT. In particular, category theory characterizes mathematical structures by their "universal mapping properties" -- a unique-existence condition for all instances of the structure. Accordingly, axioms 1-5 pertain to universal mapping properties for experience, whence the slogan, "Consciousness is a universal property.", Comment: 33 pages, 4 figures
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- 2024
25. WxC-Bench: A Novel Dataset for Weather and Climate Downstream Tasks
- Author
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Shinde, Rajat, Phillips, Christopher E., Ankur, Kumar, Gupta, Aman, Pfreundschuh, Simon, Roy, Sujit, Kirkland, Sheyenne, Gaur, Vishal, Lin, Amy, Sheshadri, Aditi, Nair, Udaysankar, Maskey, Manil, and Ramachandran, Rahul
- Subjects
Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
High-quality machine learning (ML)-ready datasets play a foundational role in developing new artificial intelligence (AI) models or fine-tuning existing models for scientific applications such as weather and climate analysis. Unfortunately, despite the growing development of new deep learning models for weather and climate, there is a scarcity of curated, pre-processed machine learning (ML)-ready datasets. Curating such high-quality datasets for developing new models is challenging particularly because the modality of the input data varies significantly for different downstream tasks addressing different atmospheric scales (spatial and temporal). Here we introduce WxC-Bench (Weather and Climate Bench), a multi-modal dataset designed to support the development of generalizable AI models for downstream use-cases in weather and climate research. WxC-Bench is designed as a dataset of datasets for developing ML-models for a complex weather and climate system, addressing selected downstream tasks as machine learning phenomenon. WxC-Bench encompasses several atmospheric processes from meso-$\beta$ (20 - 200 km) scale to synoptic scales (2500 km), such as aviation turbulence, hurricane intensity and track monitoring, weather analog search, gravity wave parameterization, and natural language report generation. We provide a comprehensive description of the dataset and also present a technical validation for baseline analysis. The dataset and code to prepare the ML-ready data have been made publicly available on Hugging Face -- https://huggingface.co/datasets/nasa-impact/WxC-Bench
- Published
- 2024
26. Supporting Healthy Affect and Coping after Perceived Failure in College Students in Christian Higher Education
- Author
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Laura Phillips and Jennifer Shewmaker
- Abstract
Perceived failure in academic performance can lead to differing outcomes for students. Depending on the coping strategies that they choose, students may improve or worsen their performance. This study examined the relationship between affective components and coping strategies in college students' responses to perceived academic failure and their subsequent academic performance. Data was collected from 122 undergraduate students in 200-level micro and macroeconomics classes at a four-year Christian university in Texas. Participants completed a battery of questionnaires, including the Positive and Negative Affect Schedule (PANAS) to measure positive and negative affect in response to their first exam grade and the Brief COPE Inventory to determine the strategies that participants used to cope with their perceptions of failure on their exam. The results showed that maladaptive coping strategies mediated the relationship between post-test negative affect and subsequent improvement in standardized test scores. This article serves as a call to Christian institutions of higher education to consider how to best support students in developing effective coping strategies when faced with failure.
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- 2025
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- View/download PDF
27. Relationships and Sex Education for the Postsecular Classroom
- Author
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Richard Phillips, Julia Hirst, Thom Winterbotham, and Harriet Tucker
- Abstract
Schools in the UK and Europe, North America and Australia are introducing ambitious forms of relationships and sex education (RSE) or school-based sexuality education. For RSE to be effective it must be inclusive, recognising and respecting the needs and experiences of those who have not always been well served by sex/sexuality education. This paper considers one such group -- students with faith backgrounds -- and explores ways of delivering RSE in the 'postsecular classroom' in which religion is recognised and respected. We conducted consultative research -- designed primarily to inform the development of teaching resources -- among students and parents of faith, and RSE teachers. Focussing upon two religiously diverse cities in England, this research included systematic literature review, classroom observations and group discussions with students, and questionnaire surveys and interviews with parents and teaching staff. Informed by the findings of this research, we designed, piloted and now share evidence-based teaching resources. This illustrates one way in which RSE can be adapted for use in the postsecular classroom where faith is out in the open, but not necessarily explicitly engaged with in the lesson. Considering the perspectives of faith communities in this way can improve RSE for everyone in the classroom.
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- 2025
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- View/download PDF
28. Exploring How Museums Can Support Science Teacher Leaders as Boundary Spanners
- Author
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Sara C. Porter, Michelle Phillips, Sarah Stallings, and Ti'Era Worsley
- Abstract
Local implementation of science reform efforts in part relies on science teacher leaders (STLs) to improve science instruction in classrooms and beyond. The lack of science-specific professional learning resources drives STLs to act as boundary spanners to locate resources outside their local context to fill that gap. Museums and other informal science education centers are examples of external entities that STLs might leverage to locate resources for local science education improvement. While we know how museums support pre- and in-service science teachers, there is a gap in our understanding related to museum support for STLs. Here, we used case study research methods to analyze how a museum-based professional learning programme supported STLs, as boundary spanners to access and adapt resources for local science education reform efforts. We found that each STL reported benefiting from shared resources from the museum, as well as from their peers in their working groups. We also found that STLs reported on different elements of the professional learning programme related to their area of influence (classroom or district) and the problem of practice their group worked on. We discuss how each of the named features of the museum-based professional learning programme supported boundary spanning of STLs and end with implications and recommendations for the design of professional learning experiences to support their leadership work.
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- 2025
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29. The Roles of Student-Teacher Relationship Quality and Classroom Self-Regulatory Supports for Children's Self-Regulatory Skills in Kindergarten and First Grade
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Anna Wright, Anne Martin, Sherri Castle, Deborah A. Phillips, and Anna D. Johnson
- Abstract
Research Findings: The current study aimed to explore the independent and interactive roles of individual student-teacher relationship quality and classroom-level self-regulatory supports in kindergarten for children's self-regulatory skills in kindergarten and first grade. We did so using multiple measures of children's self-regulation, drawn from multiple sources, and a relatively new measure of classroom-level supports for self-regulation. Our sample included 726 low-income kindergartners in Tulsa, Oklahoma. Controlling for children's fall of kindergarten self-regulatory skills, student-teacher relationship quality in kindergarten was associated with children's self-regulation at the spring of kindergarten and again at the fall of first grade, but classroom-level self-regulatory supports in kindergarten were never significantly associated with children's self-regulation. Overall, associations between student-teacher relationships and children's self-regulation were stronger and more consistently significant for student-teacher conflict than closeness, and for teacher-reported than directly assessed or assessor-rated self-regulation. They did not, however, vary by classroom self-regulatory supports. Practices and Policy: Results affirm the primacy of student-teacher relationships for children's self-regulatory development across the transition into formal schooling, regardless of the quality of classroom-level supports for self-regulation. Teacher training and professional development programs should equip teachers with strategies and resources that support their ability to develop warm, responsive relationships with individual students.
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- 2025
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30. Australian Teachers' Perceptions of Safety, Violence and Limited Support in Their Workplaces
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Fiona Longmuir, Amanda McKay, Beatriz Gallo Cordoba, Kelly-Ann Allen, and Michael Phillips
- Abstract
In the context of teaching workforce shortages, this study examined teachers' perceptions of safety, role satisfaction, and their intent to remain in the profession, in Australia. Findings from two iterations of a survey of a total of 8293 teachers revealed that 20% to 25% of participants felt unsafe in their schools. The results also showed that those who felt unsafe were less likely to be satisfied with the role and more likely to intend to leave the profession. Sources of safety concerns included student and parent behaviors along with a lack of support from schools and systems. The findings highlight an urgent need to better understand how schools and education systems might foster safer, more inclusive and positive learning environments.
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- 2025
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31. Why School Bus Drivers Stay in Their Jobs
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Brian P. Carey and Susan D. Phillips
- Abstract
With the current shortage of school bus drivers in many states, access to education is at risk for the many students who get to and from school by bus. Despite the critical role drivers play, little is known about why they stay in their jobs, and what can be done to keep them. To learn more about school bus driver retention, 301 drivers in 32 districts in New York were surveyed. Drawing on an overarching model of person-environment fit, perspectives of job satisfaction, meaningful work and public service motivation were used to explore what aspects of the driver role relate to turnover intention. Findings indicated lower turnover intention when drivers reported higher extrinsic satisfaction, when they found their work to hold personal significance, and when they saw their work as a source of broader meaning for their lives. Drivers also viewed themselves as making a difference in the lives of students and considered themselves a significant part of their education. They also indicated that pay and benefits were important in their decision to stay or leave. Findings are discussed in terms of implications for school leadership practice and future research.
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- 2025
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32. Revenues and Expenditures for Public Elementary and Secondary Education: School Year 2021-22 (Fiscal Year 2022). First Look. NCES 2024-301
- Author
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National Center for Education Statistics (NCES) (ED/IES), US Census Bureau, Stephen Q. Cornman, Shannon Doyle, Clara Moore, Jeremy Phillips, and Malia R. Nelson
- Abstract
This First Look report introduces new data for national and state-level public elementary and secondary revenues and expenditures for fiscal year (FY) 2022. Specifically, this report includes the following school finance data: (1) revenue and expenditure totals; (2) revenues by source; (3) expenditures by function, subfunction, and object; (4) current expenditures; (5) revenues and current expenditures per pupil; (6) expenditures from Title I funds; and (7) revenues and expenditures from COVID-19 Federal Assistance Funds. The expenditure functions include instruction, support services, food services, and enterprise operations. The support services function is further broken down into seven subfunctions: instructional staff support services, pupil support services, general administration, school administration, operations and maintenance, student transportation, other support services (such as business services). Objects reported within a function or subfunction include salaries and wages, employee benefits, purchased services, supplies, and equipment. The purpose of a First Look report is to introduce new data through the presentation of tables containing descriptive information. The selected findings chosen for this report demonstrate the range of information available when using NPEFS. They do not represent all of the data and are not meant to emphasize any particular issue. While the tables in this report include data for all NPEFS respondents, the selected findings are limited to the 50 states and the District of Columbia.
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- 2024
33. Revenues and Expenditures for Public Elementary and Secondary Education: School Year 2021-22 (Fiscal Year 2022). First Look Report. NCES 2024-301
- Author
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National Center for Education Statistics (NCES) (ED/IES), US Census Bureau, Stephen Q. Cornman, Shannon Doyle, Clara Moore, Jeremy Phillips, and Malia R. Nelson
- Abstract
This First Look report introduces new data for national and state-level public elementary and secondary revenues and expenditures for fiscal year (FY) 2022. Specifically, this report includes the following school finance data: (1) revenue and expenditure totals; (2) revenues by source; (3) expenditures by function, subfunction, and object; (4) current expenditures; (5) revenues and current expenditures per pupil; (6) expenditures from Title I funds; and (7) revenues and expenditures from COVID-19 Federal Assistance Funds. The expenditure functions include instruction, support services, food services, and enterprise operations. The support services function is further broken down into seven subfunctions: instructional staff support services, pupil support services, general administration, school administration, operations and maintenance, student transportation, other support services (such as business services).1 Objects reported within a function or subfunction include salaries and wages, employee benefits, purchased services, supplies, and equipment. The finance data used in this report are from the National Public Education Financial Survey (NPEFS), a component of the Common Core of Data (CCD). The CCD is one of NCES's primary survey programs on public elementary and secondary education in the United States. State education agencies (SEAs) in each of the 50 states, the District of Columbia, and the five other jurisdictions of American Samoa, Guam, the Commonwealth of the Northern Mariana Islands, Puerto Rico, and the U.S. Virgin Islands report these data annually to NCES. The NPEFS instructions ask SEAs to report revenues and expenditures covering prekindergarten through high school public education in regular, special, and vocational schools; charter schools; and state-run education programs (such as special education schools or education programs for incarcerated youth).
- Published
- 2024
34. A symbolic defeat?: Exploring symbolism and failure in the social reuse of confiscated mafia real estate in Italy
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Phillips, Amber
- Published
- 2024
35. Task and Timing Effects in Argument Role Sensitivity: Evidence from Production, EEG, and Computational Modeling
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Masato Nakamura, Shota Momma, Hiromu Sakai, and Colin Phillips
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Comprehenders generate expectations about upcoming lexical items in language processing using various types of contextual information. However, a number of studies have shown that argument roles do not impact neural and behavioral prediction measures. Despite these robust findings, some prior studies have suggested that lexical prediction might be sensitive to argument roles in production tasks such as the cloze task or in comprehension tasks when additional time is available for prediction. This study demonstrates that both the task and additional time for prediction independently influence lexical prediction using argument roles, via evidence from closely matched electroencephalogram (EEG) and speeded cloze experiments. In order to investigate the timing effect, our EEG experiment used maximally simple Japanese stimuli such as "Bee-nom/acc sting," and it manipulated the time for prediction by changing the temporal interval between the context noun and the target verb without adding any further linguistic content. In order to investigate the task effect, we conducted a speeded cloze study that was matched with our EEG study both in terms of stimuli and the time available for prediction. We found that both the EEG study with additional time for prediction and the speeded cloze study with matched timing showed clear sensitivity to argument roles, while the EEG conditions with less time for prediction replicated the standard pattern of argument role insensitivity. Based on these findings, we propose that lexical prediction is initially insensitive to argument roles but a monitoring mechanism serially inhibits role-inappropriate candidates. This monitoring process operates quickly in production tasks, where it is important to quickly select a single candidate to produce, whereas it may operate more slowly in comprehension tasks, where multiple candidates can be maintained until a continuation is perceived. Computational simulations demonstrate that this mechanism can successfully explain the task and timing effects observed in our experiments.
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- 2024
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36. An Examination of Self-Care Research in School Psychology
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Stephanie Flood, Shanye Phillips, Kristyn Goodwin, Rachel McConnell, Lindsay Matthews, and Scott Graves
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Self-care is a form of intentional focus on mental and physical wellness that is necessary for the optimal functioning of psychologists. The discussion of this topic has received an increased interest in the field of school psychology as self-care is one way to combat a well-documented concern in the field, burnout. While that is the case, there both is a lack of research and a lack of understanding regarding the effectiveness of self-care interventions. This study examined the characteristics of the literature surrounding self-care specific to the field of school psychology using the following peer-reviewed journals: "Contemporary School Psychology," "International Journal of School and Educational Psychology," "Journal of Applied School Psychology," "Journal of Educational and Psychological Consultation," "Journal of School Psychology," "Psychology in the Schools," "School Mental Health," "School Psychology International," "School Psychology (Quarterly)," and "School Psychology Review." A bibliometric analysis was completed, and results indicated that 25 articles met inclusion criteria. Results demonstrated that the number of publications increased over the years (from 2005 on) with many of the articles being published in the last 4 years. "Contemporary School Psychology" and "School Mental Health" were the two most productive journals. Interestingly, most of the included articles did not discuss school psychologists and their self-care but instead addressed populations school psychologists serve. Included empirical articles primarily used mindfulness-based interventions and didactic methods as self-care interventions. Implications are discussed in terms of future research on the topic of self-care and combating burnout for practitioners.
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- 2024
- Full Text
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37. Community Recommendations for Adapting an Evidence-Based Mental Health Intervention for Racially/Ethnically Diverse Schools: A Qualitative Study
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Sara M. St. George, Clarissa V. Velez, Yeojin A. Ahn, Dominique A. Phillips, Elizabeth R. Pulgaron, and Jill Ehrenreich-May
- Abstract
The goal of this qualitative study was to understand the perspectives of school community members (adolescents, parents, school administrators, teachers, mental health providers) regarding the adaptation of an evidence-based transdiagnostic mental health treatment, known as the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents, for delivery in racially/ethnically diverse schools. Thirty-three school community members (n = 9 adolescents, n = 4 parents, n = 5 school administrators, n = 10 teachers, n = 5 mental health providers) participated in a series of focus groups or individual interviews. We used a rapid qualitative analysis to summarize their recommendations for adapting our intervention across seven themes: (1) consider social determinants of health, (2) include content related to social media and digital literacy, (3) provide teachers and staff with training on identifying and referring to mental health services and basic psychoeducation, (4) build trust and reduce stigma, (5) use qualified mental health providers to conduct culturally relevant sessions in person during school hours, (6) consider flexible format offerings and extended intervention delivery window, and (7) anticipate low parental engagement. These data were critical for informing systematic content and procedural modifications to our adapted intervention, such as scheduling sessions for school lunch hours and identifying coaches (e.g., teachers, school administrators) to support students with check-ins regarding session attendance and skill practice. These adaptations may be applied more broadly to the implementation of evidence-based mental health interventions in diverse school settings.
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- 2024
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38. Drivers of Digital Realities for Ongoing Teacher Professional Learning
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O. Trevisan, R. Christensen, K. Drossel, S. Friesen, A. Forkosh-Baruch, and M. Phillips
- Abstract
In an era marked by the widespread use of digital technology, educators face the need to constantly learn and develop their own new literacies for the information era, as well as their competencies to teach and apply best practices using technologies. This paper underscores the vital role of ongoing teacher professional learning (OTPL) with a focus on reflective practices and pedagogical reasoning and action (PR&A) in shaping education quality and equity. Examining three key drivers of educational transformation--big data and learning analytics, Artificial Intelligence (AI), and shifting teacher identities--the paper explores their overall impact on teacher practices. This paper emphasizes technology as a crucial boundary object, a catalyst of educational transformation, when used to foster communication and professional growth. To this end, three boundary objects are identified, namely dashboards, AI-driven professional learning environments, and digital communities of practice. These tools illustrate technology's capacity to mediate relationships between transformative educational drivers and teacher practices, offering a pathway to navigate shifting perspectives on OTPL. With a theoretical foundation in equitable education, the paper provides insights into the intricate relationship between boundary objects and evolving educational dynamics. It highlights technology's pivotal role in achieving both quality and equitable education in the contemporary educational landscape. It presents a nuanced understanding of how specific tools may contribute to effective OTPL amid rapid educational transformations.
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- 2024
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39. Perceiving Palestrina
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PHILLIPS, PETER
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- 2024
40. Special announcement
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PHILLIPS, PETER
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- 2024
41. Quality-of-Life Outcomes Following Endoscopic Resection of Sinonasal Inverted Papilloma.
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Abiri, Arash, Hong, Ellen, Dilley, Katelyn, Nguyen, Theodore, Salmon, Mandy, Grose, Elysia, Tripathi, Siddhant, Venkatesh, Sanjena, Kim, Yohan, Lee, Daniel, Douglas, Jennifer, Eide, Jacob, Kshirsagar, Rijul, Phillips, Katie, Sedaghat, Ahmad, Lee, John, Tong, Charles, Adappa, Nithin, Palmer, James, and Kuan, Edward
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Schneiderian cell papilloma ,endoscopic surgery ,inverted papilloma ,quality of life ,Humans ,Quality of Life ,Papilloma ,Inverted ,Male ,Female ,Middle Aged ,Retrospective Studies ,Endoscopy ,Paranasal Sinus Neoplasms ,Aged ,Treatment Outcome ,Adult ,Postoperative Period - Abstract
OBJECTIVES: There is growing interest in assessing patient quality of life (QOL) following treatment of sinonasal tumors, including inverted papilloma (IP). We aimed to elucidate the natural history of postoperative QOL outcomes in IP patients treated with surgery. METHODS: Cases of sinonasal IP treated surgically at 4 tertiary academic rhinology centers were retrospectively reviewed. SNOT-22 scores were used to evaluate QOL preoperatively and postoperatively (1, 3, 6, 12 months). Repeated-measures ANOVA assessed for differences in mean scores over time. Linear regression identified factors associated with QOL longitudinally. RESULTS: 373 patients were analyzed. Mean preoperative SNOT-22 score was 20.6 ± 20.4, which decreased to 16.3 ± 18.8 (p = 0.041) and 11.8 ± 15.0 (p 0.05). When analyzed by SNOT-22 subdomains, nasal, sleep, and otologic/facial subdomain scores (all p 0.05). CONCLUSIONS: QOL outcomes related to IP resection are largely driven by nasal, sleep, and otologic/facial subdomains, though patients appear to experience enduring improvement as early as 3 months postoperatively. Recurrent disease is a major driver of negative QOL. LEVEL OF EVIDENCE: 4 Laryngoscope, 135:579-585, 2025.
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- 2025
42. Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses
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Lucas, Calixto-Hope G, Al-Adli, Nadeem N, Young, Jacob S, Gupta, Rohit, Morshed, Ramin A, Wu, Jasper, Ravindranathan, Ajay, Shai, Anny, Oberheim Bush, Nancy Ann, Taylor, Jennie W, de Groot, John, Villanueva-Meyer, Javier E, Pekmezci, Melike, Perry, Arie, Bollen, Andrew W, Theodosopoulos, Philip V, Aghi, Manish K, Chang, Edward F, Hervey-Jumper, Shawn L, Raleigh, David R, Molinaro, Annette M, Costello, Joseph F, Diaz, Aaron A, Clarke, Jennifer L, Butowski, Nicholas A, Phillips, Joanna J, Chang, Susan M, Berger, Mitchel S, and Solomon, David A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Neurosciences ,Human Genome ,Orphan Drug ,Cancer Genomics ,Genetics ,Cancer ,Brain Disorders ,Rare Diseases ,Brain Cancer ,2.1 Biological and endogenous factors ,DNA methylation ,glioblastoma ,gliosarcoma ,molecular neuropathology ,temozolomide-induced hypermutation ,Humans ,Glioblastoma ,Isocitrate Dehydrogenase ,Brain Neoplasms ,DNA Methylation ,Male ,Prognosis ,Middle Aged ,Female ,Mutation ,Neoplasm Recurrence ,Local ,Temozolomide ,Phenotype ,Adult ,Aged ,Biomarkers ,Tumor ,Longitudinal Studies ,Survival Rate ,Follow-Up Studies ,Promoter Regions ,Genetic ,DNA Modification Methylases ,Tumor Suppressor Proteins ,DNA Repair Enzymes ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundDespite recent advances in the biology of IDH-wildtype glioblastoma, it remains a devastating disease with median survival of less than 2 years. However, the molecular underpinnings of the heterogeneous response to the current standard-of-care treatment regimen consisting of maximal safe resection, adjuvant radiation, and chemotherapy with temozolomide remain unknown.MethodsComprehensive histopathologic, genomic, and epigenomic evaluation of paired initial and recurrent glioblastoma specimens from 106 patients was performed to investigate the molecular evolution and cellular phenotypes underlying differential treatment responses.ResultsWhile TERT promoter mutation and CDKN2A homozygous deletion were early events during gliomagenesis shared by initial and recurrent tumors, most other recurrent genetic alterations (eg, EGFR, PTEN, and NF1) were commonly private to initial or recurrent tumors indicating acquisition later during clonal evolution. Furthermore, glioblastomas exhibited heterogeneous epigenomic evolution with subsets becoming more globally hypermethylated, hypomethylated, or remaining stable. Glioblastoma that underwent sarcomatous transformation had shorter interval to recurrence and were significantly enriched in NF1, TP53, and RB1 alterations and the mesenchymal epigenetic class. Patients who developed somatic hypermutation following temozolomide treatment had significantly longer interval to disease recurrence and prolonged overall survival, and increased methylation at 4 specific CpG sites in the promoter region of MGMT was significantly associated with this development of hypermutation. Finally, an epigenomic evolution signature incorporating change in DNA methylation levels across 347 critical CpG sites was developed that significantly correlated with clinical outcomes.ConclusionsGlioblastoma undergoes heterogeneous genetic, epigenetic, and cellular evolution that underlies prognostically different treatment responses.
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- 2025
43. ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip.
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Lee, John, Tao, Ran, You, Zhen, Haldipur, Parthiv, Erickson, Anders, Farooq, Hamza, Hendriske, Liam, Abeysundara, Namal, Richman, Cory, Wang, Evan, Das Gupta, Neha, Hadley, Jennifer, Batts, Melissa, Mount, Christopher, Wu, Xiaochong, Rasnitsyn, Alex, Bailey, Swneke, Cavalli, Florence, Morrissy, Sorana, Garzia, Livia, Michealraj, Kulandaimanuvel, Visvanathan, Abhi, Fong, Vernon, Palotta, Jonelle, Suarez, Raul, Livingston, Bryn, Liu, Miao, Luu, Betty, Daniels, Craig, Loukides, James, Bendel, Anne, French, Pim, Kros, Johan, Korshunov, Andrey, Kool, Marcel, Chico Ponce de León, Fernando, Perezpeña-Diazconti, Mario, Lach, Boleslaw, Singh, Sheila, Leary, Sarah, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji-Yeoun, Tominaga, Teiji, Weiss, William, Phillips, Joanna, Dai, Shizhong, Zadeh, Gelareh, Saad, Ali, Bognár, László, Klekner, Almos, Pollack, Ian, Hamilton, Ronald, Ra, Young-Shin, Grajkowska, Wieslawa, Perek-Polnik, Marta, Thompson, Reid, Kenney, Anna, Cooper, Michael, Mack, Stephen, Jabado, Nada, Lupien, Mathieu, Gallo, Marco, Ramaswamy, Vijay, Suva, Mario, Suzuki, Hiromichi, Millen, Kathleen, Huang, L, Northcott, Paul, and Taylor, Michael
- Abstract
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma). Overexpression of ZIC1 suppresses the growth of group 3 medulloblastoma models, whereas it promotes the proliferation of SHH medulloblastoma precursor cells. SHH medulloblastoma ZIC1 mutants show increased activity versus wild-type ZIC1, whereas G4 medulloblastoma ZIC1 mutants exhibit LOF phenotypes. Distinct ZIC1 mutations affect cells of the rhombic lip in diametrically opposed ways, suggesting that ZIC1 is a critical developmental transcriptional regulator in both the normal and transformed rhombic lip and identifying ZIC1 as an exquisitely context-dependent driver gene in medulloblastoma.
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- 2025
44. Overview of chronic hepatitis B management.
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Jun, Angela, Bau, Sherona, Kim, John, and Phillips, Susanne
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Humans ,Antiviral Agents ,Hepatitis B ,Chronic ,Nurse Practitioners - Abstract
Chronic hepatitis B remains a substantial global health challenge, impacting approximately 254 million people worldwide. A cure for this condition is yet to be discovered. Early identification and effective treatments coupled with vigilant monitoring can help alleviate associated morbidity and mortality due to potential complications such as liver cirrhosis and hepatocellular carcinoma.
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- 2025
45. Genome-wide association analysis of composite sleep health scores in 413,904 individuals
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Goodman, Matthew O, Faquih, Tariq, Paz, Valentina, Nagarajan, Pavithra, Lane, Jacqueline M, Spitzer, Brian, Maher, Matthew, Chung, Joon, Cade, Brian E, Purcell, Shaun M, Zhu, Xiaofeng, Noordam, Raymond, Phillips, Andrew JK, Kyle, Simon D, Spiegelhalder, Kai, Weedon, Michael N, Lawlor, Deborah A, Rotter, Jerome I, Taylor, Kent D, Isasi, Carmen R, Sofer, Tamar, Dashti, Hassan S, Rutter, Martin K, Redline, Susan, Saxena, Richa, and Wang, Heming
- Subjects
Biological Sciences ,Genetics ,Behavioral and Social Science ,Neurosciences ,Prevention ,Human Genome ,Sleep Research ,Basic Behavioral and Social Science ,2.1 Biological and endogenous factors ,Generic health relevance ,Good Health and Well Being ,Genome-Wide Association Study ,Humans ,Sleep ,Male ,Female ,Polymorphism ,Single Nucleotide ,Middle Aged ,Adult ,Biological sciences ,Biomedical and clinical sciences - Abstract
Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds of genetic loci, suggesting diverse mechanisms. Moreover, sleep traits are moderately correlated, so together may provide a more complete picture of sleep health, while illuminating distinct domains. Here we construct novel sleep health scores (SHSs) incorporating five core self-report measures: sleep duration, insomnia symptoms, chronotype, snoring, and daytime sleepiness, using additive (SHS-ADD) and five principal components-based (SHS-PCs) approaches. GWASs of these six SHSs identify 28 significant novel loci adjusting for multiple testing on six traits (p
- Published
- 2025
46. Radiographic findings in dogs with 360 degrees gastric dilatation and volvulus.
- Author
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Mur, Pablo, Appleby, Ryan, Phillips, Kathryn, Singh, Ameet, Monteith, Gabrielle, Gilmour, Lindsey, Keenihan, Erin, Daniaux, Lise, and Linden, Alex
- Subjects
360 ,dogs ,gastric volvulus ,radiographs ,Animals ,Dogs ,Dog Diseases ,Gastric Dilatation ,Stomach Volvulus ,Retrospective Studies ,Male ,Female ,Sensitivity and Specificity ,Radiography ,Observer Variation - Abstract
Gastric dilatation and volvulus (GDV) is a life-threatening emergency that requires urgent intervention. Radiographic features associated with 360-GDV in dogs have not been investigated. The aim of this retrospective observational study is to describe radiographic features and clinical variables in dogs affected with 360-GDV and to report agreement rates between different radiologists. We also report the sensitivity and specificity of radiographs to diagnose 360-GDV in dogs. Confirmed 360-GDV cases were retrieved, and the radiographic findings were compared with dogs presenting with gastric dilatation (GD) and 180-GDV. Images were reviewed and graded by three blinded board-certified radiologists. A total of 16 dogs with confirmed 360-GDV were identified. The median age was 10 years old (2-13 years). The sensitivity for detection of 360-GDV ranged between 43.7% and 50%, and the specificity between 84.6% and 92.1%. Interobserver agreement on final diagnosis was substantial (Kappa = 0.623; 0.487-0.760, 95% CI). The highest agreement rate was in cases of 180-GDV (87%), followed by the GD cases (72%) and 360-GDV (46%). Severe esophageal distension and absence of small intestinal dilation were the only radiographic features specifically associated with 360-GDV. A similar pyloric position was found between GD and 360-GDV. Additional radiographic variables that could help differentiate GD from 360-GDV include the degree of gastric distension and the peritoneal serosal contrast. Two cases with 360-GDV were misdiagnosed by the three radiologists as GD. In conclusion, radiographically, 360-GDV cases can reassemble GD and vice versa. Radiologists and clinicians should be aware of the low sensitivity of radiographs for the detection of 360-GDV.
- Published
- 2025
47. Opioid and Drug Dependence on University Campuses
- Author
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Yassin, Lamis, Duong, Mindy, Bravo, Kyo, Kaufman, Ella, Qian, Emily, Phillips, Josie, Lee, Yune, Castellanos, Edith, and Nobriga, Alyson
- Subjects
Opioid ,Drug Dependence ,Policy ,Proposal ,Healthcare ,University Campus Safety - Abstract
The prevalence of opioid use disorder and overdose is continually growing on college campuses. Unfortunately, most university staff are not properly equipped to handle this reality. This can lead to devastating impacts to university students, staff, and families. Reality is, staff members need to be equipped to help and manage students in life threatening situations related to opioid use. This proposal aims to directly tackle this issue through a mandated drug overdose response procedure certification. This would be a requirement for university resident assistants, RAs, and security staff. This would be a requirement for public universities and staff would take the course during the onboarding process with a yearly review course. A solution like this can save many lives and allow for a safer campus that will further academic and personal success. The proposal will require funding for curriculum building, reimbursement for staff that undergo the training, and purchase of naloxone kits.
- Published
- 2024
48. High and low current perceived stress associated with enhanced emotional mnemonic discrimination.
- Author
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Vas, Rishi, Phillips, Taylor, Ferguson, Lorena, Harikumar, Amritha, Castro, Madelyn, and Leal, Stephanie
- Subjects
Humans ,Stress ,Psychological ,Young Adult ,Adult ,Male ,Female ,Emotions ,Adolescent ,Discrimination ,Psychological ,Recognition ,Psychology - Abstract
Stress can have profound impacts on memory. However, the directionality of stress effects on memory varies widely across studies, some showing enhancement while others showing impairment. This variability has been attributed to the Yerkes-Dodson Law, which proposes a U-shaped pattern such that too little or too much stress may be associated with cognitive dysfunction. The impact of stress on memory may also depend on what aspects of memory are being measured (e.g., emotional content, gist vs. detail) and how stress is measured (e.g., physiological measures, self-report). Here, we aimed to examine how self-reported perceived stress in the current moment was associated with memory performance. We used an emotional memory task designed to tap into potential gist versus detail trade-offs of stress impacting memory (e.g., target recognition, lure discrimination). Participants (ages 18-35) reported their current level of perceived stress. We replicated prior work showing impaired emotional relative to neutral lure discrimination in young adults in support of a gist versus detail trade-off in emotional memory. However, those with low and high current perceived stress showed better emotional lure discrimination compared to those with moderate current perceived stress. These results are in line with the Yerkes-Dodson Law but suggest that the directionality of the impact of stress on memory may depend on the type of memory measured. Low and high current perceived stress was associated with greater detailed memory, especially for emotional information, which may be maladaptive given gist vs. detail trade-offs in emotional memory.
- Published
- 2024
49. Arterial spin labeling perfusion MRI in the Alzheimer's Disease Neuroimaging Initiative: Past, present, and future
- Author
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Thropp, Pamela, Phillips, Eliana, Jung, Youngkyoo, Thomas, David L, Tosun, Duygu, and Initiative, for the Alzheimer's Disease Neuroimaging
- Subjects
Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Biomedical Imaging ,Dementia ,Acquired Cognitive Impairment ,Alzheimer's Disease ,Brain Disorders ,Aging ,Neurodegenerative ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Cerebrovascular ,4.1 Discovery and preclinical testing of markers and technologies ,Neurological ,Humans ,Alzheimer Disease ,Brain ,Cerebrovascular Circulation ,Magnetic Resonance Imaging ,Neuroimaging ,Spin Labels ,Alzheimer's disease ,arterial spin labeling ,arterial transit time ,cerebral blood flow ,magnetic resonance imaging ,multiple post-label delay ,Alzheimer's Disease Neuroimaging Initiative ,multiple post‐label delay ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
On the 20th anniversary of the Alzheimer's Disease Neuroimaging Initiative (ADNI), this paper provides a comprehensive overview of the role of arterial spin labeling (ASL) magnetic resonance imaging (MRI) in understanding perfusion changes in the aging brain and the relationship with Alzheimer's disease (AD) pathophysiology and its comorbid conditions. We summarize previously used acquisition protocols, available data, and the motivation for adopting a multi-post-labeling delay (PLD) acquisition scheme in the latest ADNI MRI protocol (ADNI 4). We also detail the process of setting up this scheme on different scanners, emphasizing the potential of ASL imaging in future AD research. HIGHLIGHTS: The Alzheimer's Disease Neuroimaging Initiative (ADNI) adopted multimodal arterial spin labeling magnetic resonance imaging (ASL MRI) to meet evolving biomarker requirements. The ADNI provides one of the largest multisite, multi-vendor ASL data collections. The ADNI 4 incorporates multi-post-labeling delay ASL techniques to jointly quantify cerebral blood flow and arterial transit time. ADNI 4 ASL MRI protocol is apt for detecting early Alzheimer's disease with cerebrovascular pathology.
- Published
- 2024
50. Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial
- Author
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Xu, Ava Y, Velásquez, Gustavo E, Zhang, Nan, Chang, Vincent K, Phillips, Patrick PJ, Nahid, Payam, Dorman, Susan E, Kurbatova, Ekaterina V, Whitworth, William C, Sizemore, Erin, Bryant, Kia, Carr, Wendy, Brown, Nicole E, Engle, Melissa L, Nhung, Nguyen Viet, Nsubuga, Pheona, Diacon, Andreas, Dooley, Kelly E, Chaisson, Richard E, Swindells, Susan, and Savic, Radojka M
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Clinical Research ,Infectious Diseases ,Orphan Drug ,Tuberculosis ,Clinical Trials and Supportive Activities ,Emerging Infectious Diseases ,Patient Safety ,Rare Diseases ,6.1 Pharmaceuticals ,Good Health and Well Being ,Humans ,Pyrazinamide ,Female ,Male ,Antitubercular Agents ,Adult ,Tuberculosis ,Pulmonary ,Middle Aged ,Treatment Outcome ,Dose-Response Relationship ,Drug ,Young Adult ,dose–response ,exposure–response ,population pharmacokinetics ,pyrazinamide ,tuberculosis ,Medical and Health Sciences ,Respiratory System ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Rationale: Optimizing pyrazinamide dosing is critical to improve treatment efficacy while minimizing toxicity during tuberculosis treatment. Study 31/AIDS Clinical Trials Group A5349 represents the largest phase 3 randomized controlled therapeutic trial to date for such an investigation. Objectives: We sought to report pyrazinamide pharmacokinetic parameters, risk factors for lower pyrazinamide exposure, and relationships between pyrazinamide exposure and efficacy and safety outcomes. We aimed to determine pyrazinamide dosing strategies that optimize risks and benefits. Methods: We analyzed pyrazinamide steady-state pharmacokinetic data using population nonlinear mixed-effects models. We evaluated the contribution of pyrazinamide exposure to long-term efficacy using parametric time-to-event models and safety outcomes using logistic regression. We evaluated optimal dosing with therapeutic windows targeting ≥95% durable cure and safety within the observed proportion of the primary safety outcome. Measurements and Main Results: Among 2,255 participants with 6,978 plasma samples, pyrazinamide displayed sevenfold exposure variability (151-1,053 mg·h/L). Body weight was not a clinically relevant predictor of drug clearance and thus did not justify the need for weight-banded dosing. Both clinical and safety outcomes were associated with pyrazinamide exposure, resulting in therapeutic windows of 231-355 mg · h/L for the control and 226-349 mg·h/L for the rifapentine-moxifloxacin regimen. Flat dosing of pyrazinamide at 1,000 mg would have permitted an additional 13.1% (n = 96) of participants allocated to the control and 9.2% (n = 70) to the rifapentine-moxifloxacin regimen dosed within the therapeutic window, compared with the current weight-banded dosing. Conclusions: Flat dosing of pyrazinamide at 1,000 mg/d would be readily implementable and could optimize treatment outcomes in drug-susceptible tuberculosis. Clinical trial registered with www.clinicaltrials.gov (NCT02410772).
- Published
- 2024
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