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Optical brain monitoring, such as near-infrared spectroscopy (NIRS), has facilitated numerous brain studies, including those based on machine learning techniques. A large and diverse dataset is necessary for training machine learning algorithms to avoid overfitting a limited amount of data. However, recruiting sufficient subjects is challenging owing to time and budget constraints. Therefore, we propose an NIRS data generation algorithm that scales NIRS signal components, such as hemodynamic response function, physiological systemic noise, and instrumental spike noise, based on the source-detector distance to augment the training data. Experimental self-paced left- and right-hand motor imagery data were augmented with generated NIRS data to train a convolutional neural network and classify the motor imagery data. Augmenting the training dataset with 1000 generated data increased the classification accuracy to 86.3 ± 4.1%, a 26% increase compared with training on experimental data only. In addition, we applied Guided Gradient-weighted Class Activation Mapping (Grad-CAM) to visualize the class discriminative features of the input data. The peaks of Guided Grad-CAM heatmaps aligned with the oxy-hemoglobin peaks during self-paced motor imagery. We concluded that the increased cerebral oxygenation, especially in the contralateral hemisphere, was the class-discriminative feature for classifying left- and right-hand motor imagery.

Background: The monitoring of brain activity along with genital organ response to sexual stimulation can play an important role in understanding the under-lying mechanisms of sexual arousal as well as diagnosing erectile dysfunction. Several studies have observed brain activity corresponding to sexual stimuli, but only a few studies have shown a simultaneous measurement of brain activation and penile response. Aim: To introduce near-infrared spectroscopy (NIRS) as a portable, easily implemented, and low-cost technique to simultaneously record brain activity and hemodynamics in the genital organ during sexual arousal. Methods: Hemodynamic measurements of 15 healthy men were obtained using a home-built NIRS system. In the initial experiment, hemodynamics in the pre-frontal cortex (N = 10) were measured during visual sexual stimulation (VSS) and neutral visual stimulation (NVS) to identify brain activity related to sexual arousal. In the subsequent experiment, cerebral and penile hemodynamics were simultaneously measured (N = 5) using NIRS during VSS and NVS. Results: The pre-frontal cortex showed activity related to VSS but not to NVS. Simultaneous measurements showed a corresponding increase of penile oxygenated and deoxygenated hemoglobin concentration indicating an increase of blood volume associated with sexual arousal in healthy men. An average response delay of 4 seconds was observed in the hemodynamic changes between the brain and genital organ. Conclusion: In this preliminary study, we presented a NIRS system capable not only of detecting cerebral hemodynamic changes related to sexual arousal but also the simultaneous measurement of penile hemodynamics. We believe the NIRS system can be a potential technique to supplement the field of sexual medicine and can be expanded further to diagnose erectile dysfunction.Kim E, Kim S, Zephaniah PV, et al. Simultaneous Monitoring of Hemodynamic Response in the Pre-Frontal Cortex and Genital Organ During Sexual Arousal Using Near-Infrared Spectroscopy. Sex Med 2018;6:234–238. Key Words: Near-Infrared Spectroscopy, Hemodynamics, Pre-Frontal Cortex, Visual Sexual Stimulation, Erectile Dysfunction

The head-up tilt table test (HUT) is one of the primary clinical examinations for evaluating orthostatic intolerance (OI). HUT can be divided into three phases: dynamic tilt phase (supine to tilt up), static tilt phase (remain tilted at 70°), and post tilt phase (tilt down back to supine position). Commonly, blood pressure (BP) and heart rate (HR) are monitored to observe for OI symptoms, but are indirect measurements of cerebral perfusion and can lead to inaccurate HUT evaluation. In this study, we implemented a 108-channel near-infrared spectroscopy (NIRS) probe to characterize HUT performance by monitoring cerebral hemodynamic changes for healthy controls (HCs), OI patients with normal HUT results, and OI patients with positive HUT results: vasovagal syncope (VS), postural orthostatic tachycardia syndrome (POTS), orthostatic hypotension (OH), and orthostatic hypertension (OHT). By the end of the static tilt phase, OI patients typically did not show a complete recovery back to baseline cerebral oxygenation and total blood volume compared to HCs. We characterized the return to cerebral homeostasis by polynomial fitting total blood volume changes and determining the inflection point. The OI patients with normal HUT results, VS, OH, or OHT showed a delay in the return to cerebral homeostasis compared to the HC group during HUT.

An updated version of the spectral (bin) microphysics cloud model developed at the Hebrew University of Jerusalem [the Hebrew University Cloud Model (HUCM)] is described. The model microphysics is based on the solution of the equation system for size distribution functions of cloud hydrometeors of seven types (water drops, plate-, columnar-, and branch-like ice crystals, aggregates, graupel, and hail/frozen drops) as well as for the size distribution function of aerosol particles playing the role of cloud condensational nuclei (CCN). Each size distribution function contains 33 mass bins. The conditions allowing numerical reproduction of a narrow droplet spectrum up to the level of homogeneous freezing in deep convective clouds developed in smoky air are discussed and illustrated using as an example Rosenfeld and Woodley's case of deep Texas clouds. The effects of breakup on precipitation are illustrated by the use of a new collisional breakup scheme. Variation of the microphysical structure of a melting layer is illustrated by using the novel melting procedure. It is shown that an increase in the aerosol concentration leads to a decrease in precipitation from single clouds both under continental and maritime conditions. To provide similar precipitation, a cloud developed in smoky air should have a higher top height. The mechanisms are discussed through which aerosols decrease precipitation efficiency. It is shown that aerosols affect the vertical profile of the convective beating caused by latent heat release.