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276 results on '"Phillips, Phoebe A."'

1. A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Author

Chitty, Jessica L., Yam, Michelle, Perryman, Lara, Parker, Amelia L., Skhinas, Joanna N., Setargew, Yordanos F. I., Mok, Ellie T. Y., Tran, Emmi, Grant, Rhiannon D., Latham, Sharissa L., Pereira, Brooke A., Ritchie, Shona C., Murphy, Kendelle J., Trpceski, Michael, Findlay, Alison D., Melenec, Pauline, Filipe, Elysse C., Nadalini, Audrey, Velayuthar, Sipiththa, Major, Gretel, Wyllie, Kaitlin, Papanicolaou, Michael, Ratnaseelan, Shivanjali, Phillips, Phoebe A., Sharbeen, George, Youkhana, Janet, Russo, Alice, Blackwell, Antonia, Hastings, Jordan F., Lucas, Morghan C., Chambers, Cecilia R., Reed, Daniel A., Stoehr, Janett, Vennin, Claire, Pidsley, Ruth, Zaratzian, Anaiis, Da Silva, Andrew M., Tayao, Michael, Charlton, Brett, Herrmann, David, Nobis, Max, Clark, Susan J., Biankin, Andrew V., Johns, Amber L., Croucher, David R., Nagrial, Adnan, Gill, Anthony J., Grimmond, Sean M., Pajic, Marina, Timpson, Paul, Jarolimek, Wolfgang, and Cox, Thomas R.

Published
2023
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5. Abstract B062: CRO67 has therapeutic potential against pancreatic tumor cells and cancer associated fibroblasts

Author

Netto, Keilah Garcia, primary, Chiang, Shannon, additional, Kokkinos, John, additional, Haghighi, Koroush S., additional, Raina, Aparna, additional, Pitiyarachchi, Omali, additional, Youkhana, Janet, additional, Truong, Quach, additional, Wenholz, Daniel, additional, Li, Xiang, additional, Laczka, Olivier, additional, Kumar, Naresh, additional, Wilkinson, John, additional, Goldstein, David, additional, Sharbeen, George, additional, and Phillips, Phoebe A., additional

Published
2024
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6. Ex vivo culture of intact human patient derived pancreatic tumour tissue

Author

Kokkinos, John, Sharbeen, George, Haghighi, Koroush S., Ignacio, Rosa Mistica C., Kopecky, Chantal, Gonzales-Aloy, Estrella, Youkhana, Janet, Timpson, Paul, Pereira, Brooke A., Ritchie, Shona, Pandzic, Elvis, Boyer, Cyrille, Davis, Thomas P., Butler, Lisa M., Goldstein, David, McCarroll, Joshua A., and Phillips, Phoebe A.

Published
2021
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7. Development of a long term, ex vivo, patient-derived explant model of endometrial cancer.

Author

van der Woude, Hannah, Phan, Khoi, Kenwright, Diane N., Goossens, Louise, Hally, Kathryn Elizabeth, Currie, Margaret Jane, Kokkinos, John, Sharbeen, George, Phillips, Phoebe A., and Henry, Claire Elizabeth

Subjects
LEVONORGESTREL, ENDOMETRIAL cancer, BODY mass index
Abstract

Incidence of endometrial cancer (EC) is rising in the developed world. The current standard of care, hysterectomy, is often infeasible for younger patients and those with high body mass index. There are limited non-surgical treatment options and a lack of biologically relevant research models to investigate novel alternatives to surgery for EC. The aim of the present study was to develop a long-term, patient-derived explant (PDE) model of early-stage EC and demonstrate its use for investigating predictive biomarkers for a current non-surgical treatment option, the levonorgestrel intra-uterine system (LNG-IUS). Fresh tumour specimens were obtained from patients with early-stage endometrioid EC. Tumours were cut into explants, cultured on media-soaked gelatin sponges for up to 21 days and treated with LNG. Formalin-fixed, paraffin embedded (FFPE) blocks were generated for each explant after 21 days in culture. Tumour architecture and integrity were assessed by haematoxylin and eosin (H&E) and immunohistochemistry (IHC). IHC was additionally performed for the expression of five candidate biomarkers of LNG resistance. The developed ex vivo PDE model is capable of culturing explants from early-stage EC tumours long-term (21 Days). This model can complement existing models and may serve as a tool to validate results obtained in higher-throughput in vitro studies. Our study provides the foundation to validate the extent to which EC PDEs reflect patient response in future research. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Peer-to-Peer Health Communication in Older Adults’ Online Communities: Protocol for a Qualitative Netnographic Study and Co-Design Approach

Author

Lawless, Michael Thomas, Archibald, Mandy, Pinero de Plaza, Maria Alejandra, Drioli-Phillips, Phoebe, and Kitson, Alison

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundOnline communities provide an environment in which people with similar health concerns can interact and access content that can support the self-management of long-term conditions (LTCs). Recently, the importance of online social networks as sources of health information and social support has been brought into focus with the emergence and widespread societal impacts of COVID-19. Although online communities exist for older adults, little is known about the specific health and self-care topics that older people discuss in such environments and how these relate to users’ support needs and outcomes. A better understanding of users’ needs and peer-to-peer communication in these communities is necessary to inform the design of information and communication technology (ICT) interventions that are relevant to older people and their peer supporters. ObjectiveThis study aims to use a two-phase, web-based ethnographic (netnography) and co-design approach to explore specific health care and self-care topics that older adults discuss in a UK-based online community and how peer supporters respond to these queries with informational and/or social support and engage with stakeholders to define the needs and requirements for new ICT-based interventions capable of reducing social isolation and facilitating LTC self-management support. MethodsThe first phase of the research will involve a qualitative netnographic analysis of posts in discussion forums in a publicly accessible online community. The second phase will involve co-design workshops with health care consumers (ie, older adults and carers) and service providers to determine the needs and requirements for new ICT-based interventions and digital innovations. Constructivist grounded theory will be used in the first phase; in the second phase, the co-design workshops will be audiorecorded and analyzed thematically. ResultsThis research project is in progress. Permission was obtained from the website administrator to use materials from the social media forum; data collection for the first phase began in April 2020. The second phase of the study is expected to begin in late 2020. This study is due to be completed by the end of 2021. ConclusionsThis study is the first, to the best of our knowledge, to combine qualitative netnography with an iterative co-design framework to specify the needs and requirements for new ICT-based interventions. The findings from this study will inform the next phase of the multiphase knowledge translation project and will provide insights into the potential of online peer health communities to reduce social isolation and facilitate chronic illness self-management support and self-care. International Registered Report Identifier (IRRID)PRR1-10.2196/19834

Published
2020
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9. HSP47: The New Heat Shock Protein Therapeutic Target

Author

Sharbeen, George, McAlpine, Shelli, Phillips, Phoebe, Bernstein, Peter R., Series editor, Buschauer, Armin, Series editor, Georg, Gunda I., Series editor, Lowe, John A., Series editor, Meanwell, Nicholas A., Series editor, Saxena, Anil Kumar, Series editor, Stilz, Ulrich, Series editor, Supuran, Claudiu T., Series editor, McAlpine, Shelli R., editor, and Edkins, Adrienne Lesley, editor

Published
2016
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12. Supplementary Table 3 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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13. Supplementary Table 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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14. Data from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., primary, Akerman, Anouschka, primary, Kopecky, Chantal, primary, Youkhana, Janet, primary, Kokkinos, John, primary, Holst, Jeff, primary, Boyer, Cyrille, primary, Erkan, Mert, primary, Goldstein, David, primary, Timpson, Paul, primary, Cox, Thomas R., primary, Pereira, Brooke A., primary, Chitty, Jessica L., primary, Fey, Sigrid K., primary, Najumudeen, Arafath K., primary, Campbell, Andrew D., primary, Sansom, Owen J., primary, Ignacio, Rosa Mistica C., primary, Naim, Stephanie, primary, Liu, Jie, primary, Russia, Nelson, primary, Lee, Julia, primary, Chou, Angela, primary, Johns, Amber, primary, Gill, Anthony J., primary, Gonzales-Aloy, Estrella, primary, Gebski, Val, primary, Guan, Yi Fang, primary, Pajic, Marina, primary, Turner, Nigel, primary, Apte, Minoti V., primary, Davis, Thomas P., primary, Morton, Jennifer P., primary, Haghighi, Koroush S., primary, Kasparian, Jorjina, primary, McLean, Benjamin J., primary, Setargew, Yordanos F., primary, and Phillips, Phoebe A., primary

Published
2023
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15. Supplementary Table 4 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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16. Supplemental Methods from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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17. Figure S2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., primary, Akerman, Anouschka, primary, Kopecky, Chantal, primary, Youkhana, Janet, primary, Kokkinos, John, primary, Holst, Jeff, primary, Boyer, Cyrille, primary, Erkan, Mert, primary, Goldstein, David, primary, Timpson, Paul, primary, Cox, Thomas R., primary, Pereira, Brooke A., primary, Chitty, Jessica L., primary, Fey, Sigrid K., primary, Najumudeen, Arafath K., primary, Campbell, Andrew D., primary, Sansom, Owen J., primary, Ignacio, Rosa Mistica C., primary, Naim, Stephanie, primary, Liu, Jie, primary, Russia, Nelson, primary, Lee, Julia, primary, Chou, Angela, primary, Johns, Amber, primary, Gill, Anthony J., primary, Gonzales-Aloy, Estrella, primary, Gebski, Val, primary, Guan, Yi Fang, primary, Pajic, Marina, primary, Turner, Nigel, primary, Apte, Minoti V., primary, Davis, Thomas P., primary, Morton, Jennifer P., primary, Haghighi, Koroush S., primary, Kasparian, Jorjina, primary, McLean, Benjamin J., primary, Setargew, Yordanos F., primary, and Phillips, Phoebe A., primary

Published
2023
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18. Supplementary Table 2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., primary, Akerman, Anouschka, primary, Kopecky, Chantal, primary, Youkhana, Janet, primary, Kokkinos, John, primary, Holst, Jeff, primary, Boyer, Cyrille, primary, Erkan, Mert, primary, Goldstein, David, primary, Timpson, Paul, primary, Cox, Thomas R., primary, Pereira, Brooke A., primary, Chitty, Jessica L., primary, Fey, Sigrid K., primary, Najumudeen, Arafath K., primary, Campbell, Andrew D., primary, Sansom, Owen J., primary, Ignacio, Rosa Mistica C., primary, Naim, Stephanie, primary, Liu, Jie, primary, Russia, Nelson, primary, Lee, Julia, primary, Chou, Angela, primary, Johns, Amber, primary, Gill, Anthony J., primary, Gonzales-Aloy, Estrella, primary, Gebski, Val, primary, Guan, Yi Fang, primary, Pajic, Marina, primary, Turner, Nigel, primary, Apte, Minoti V., primary, Davis, Thomas P., primary, Morton, Jennifer P., primary, Haghighi, Koroush S., primary, Kasparian, Jorjina, primary, McLean, Benjamin J., primary, Setargew, Yordanos F., primary, and Phillips, Phoebe A., primary

Published
2023
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19. Data from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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20. Supplementary Table 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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21. Supplementary Figure 1 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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22. Supplementary Table 4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., primary, Akerman, Anouschka, primary, Kopecky, Chantal, primary, Youkhana, Janet, primary, Kokkinos, John, primary, Holst, Jeff, primary, Boyer, Cyrille, primary, Erkan, Mert, primary, Goldstein, David, primary, Timpson, Paul, primary, Cox, Thomas R., primary, Pereira, Brooke A., primary, Chitty, Jessica L., primary, Fey, Sigrid K., primary, Najumudeen, Arafath K., primary, Campbell, Andrew D., primary, Sansom, Owen J., primary, Ignacio, Rosa Mistica C., primary, Naim, Stephanie, primary, Liu, Jie, primary, Russia, Nelson, primary, Lee, Julia, primary, Chou, Angela, primary, Johns, Amber, primary, Gill, Anthony J., primary, Gonzales-Aloy, Estrella, primary, Gebski, Val, primary, Guan, Yi Fang, primary, Pajic, Marina, primary, Turner, Nigel, primary, Apte, Minoti V., primary, Davis, Thomas P., primary, Morton, Jennifer P., primary, Haghighi, Koroush S., primary, Kasparian, Jorjina, primary, McLean, Benjamin J., primary, Setargew, Yordanos F., primary, and Phillips, Phoebe A., primary

Published
2023
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23. Supplementary Figure 2 from Fibroblasts from Distinct Pancreatic Pathologies Exhibit Disease-Specific Properties

Author

Barrera, Lawrence N., primary, Evans, Anthony, primary, Lane, Brian, primary, Brumskill, Sarah, primary, Oldfield, Frances E., primary, Campbell, Fiona, primary, Andrews, Timothy, primary, Lu, Zipeng, primary, Perez-Mancera, Pedro A., primary, Liloglou, Triantafillos, primary, Ashworth, Milton, primary, Jalali, Mehdi, primary, Dawson, Rebecca, primary, Nunes, Quentin, primary, Phillips, Phoebe A., primary, Timms, John F., primary, Halloran, Christopher, primary, Greenhalf, William, primary, Neoptolemos, John P., primary, and Costello, Eithne, primary

Published
2023
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26. CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Author

Vennin, Claire, Mélénec, Pauline, Rouet, Romain, Nobis, Max, Cazet, Aurélie S., Murphy, Kendelle J., Herrmann, David, Reed, Daniel A., Lucas, Morghan C., Warren, Sean C., Elgundi, Zehra, Pinese, Mark, Kalna, Gabriella, Roden, Daniel, Samuel, Monisha, Zaratzian, Anaiis, Grey, Shane T., Da Silva, Andrew, Leung, Wilfred, Australian Pancreatic Genome Initiative (APGI), Mathivanan, Suresh, Wang, Yingxiao, Braithwaite, Anthony W., Christ, Daniel, Benda, Ales, Parkin, Ashleigh, Phillips, Phoebe A., Whitelock, John M., Gill, Anthony J., Sansom, Owen J., Croucher, David R., Parker, Benjamin L., Pajic, Marina, Morton, Jennifer P., Cox, Thomas R., and Timpson, Paul

Published
2019
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30. Abstract C073: CRO-67 is a novel therapeutic for pancreatic cancer: Implications for tumor and stromal reprogramming

Author

Kokkinos, John, primary, Sharbeen, George, additional, Haghighi, Koroush S., additional, Youkhana, Janet, additional, Raina, Aparna, additional, Pitiyarachchi, Omali, additional, Truong, Quach, additional, Wenholz, Daniel, additional, Laczka, Olivier, additional, Kumar, Naresh, additional, Goldstein, David, additional, and Phillips, Phoebe A., additional

Published
2022
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32. Mothers with borderline personality disorders' experiences of mother–infant dialectical behavior therapy.

Author

Francis, Jaimee L., Sawyer, Alyssa, Roberts, Rachel, Yelland, Chris, Drioli‐Phillips, Phoebe, and Sved Williams, Anne E.

Subjects
DIALECTICAL behavior therapy, BORDERLINE personality disorder, MOTHERS, MOTHER-infant relationship, EMOTION regulation, MENTAL health
Abstract

Background: Borderline personality disorder (BPD) is increasingly diagnosed in perinatal and infant settings, and research suggests that as well as an escalation of BPD symptoms in this period, these symptoms may also be detrimental to infant development. Providing tailored treatments during the postnatal period may help women and prevent an intergenerational cycle of emotional and interpersonal symptoms in infants. Mother–infant dialectical behavior therapy (MI‐DBT) has produced promising, yet inconsistent, improvements on quantitative scales of maternal mental health and the mother–infant relationship. The qualitative evaluation may provide complementary information. Aims: This study aimed to explore the subjective experiences of women who had completed MI‐DBT. Material and Methods: Thematic analysis of semistructured interviews conducted on 13 women undertaking MI‐DBT before, post, and 12 months after MI‐DBT were analyzed for themes. Results: Five major themes were identified. Overall, the women expressed that their emotional literacy and regulation improved after MI‐DBT, subsequently addressing key risks and challenges such as uncertainty around their child's cues, and low self‐esteem, and potentially improving the women's mentalization capability. Discussion and Conclusions: This study consolidates previous research on maternal BPD, and provides qualitative evidence of the benefits of MI‐DBT for mothers as both individuals and as parents with likely flow‐on effects for infants. Lived experience input for future adaptations was a valuable gain. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Cancer‐Associated Fibroblasts: Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells (Adv. Biology 6/2021)

Author

Nemec, Stephanie, primary, Lam, Joey, additional, Zhong, Jingxiao, additional, Heu, Celine, additional, Timpson, Paul, additional, Li, Qing, additional, Youkhana, Janet, additional, Sharbeen, George, additional, Phillips, Phoebe A., additional, and Kilian, Kristopher A., additional

Published
2021
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46. Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., additional, Akerman, Anouschka, additional, Kopecky, Chantal, additional, Youkhana, Janet, additional, Kokkinos, John, additional, Holst, Jeff, additional, Boyer, Cyrille, additional, Erkan, Mert, additional, Goldstein, David, additional, Timpson, Paul, additional, Cox, Thomas R., additional, Pereira, Brooke A., additional, Chitty, Jessica L., additional, Fey, Sigrid K., additional, Najumudeen, Arafath K., additional, Campbell, Andrew D., additional, Sansom, Owen J., additional, Ignacio, Rosa Mistica C., additional, Naim, Stephanie, additional, Liu, Jie, additional, Russia, Nelson, additional, Lee, Julia, additional, Chou, Angela, additional, Johns, Amber, additional, Gill, Anthony J., additional, Gonzales-Aloy, Estrella, additional, Gebski, Val, additional, Guan, Yi Fang, additional, Pajic, Marina, additional, Turner, Nigel, additional, Apte, Minoti V., additional, Davis, Thomas P., additional, Morton, Jennifer P., additional, Haghighi, Koroush S., additional, Kasparian, Jorjina, additional, McLean, Benjamin J., additional, Setargew, Yordanos F., additional, and Phillips, Phoebe A., additional

Published
2021
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47. Additional file 1 of ROR1 and ROR2 expression in pancreatic cancer

Author

Liu, Dongli, Sharbeen, George, Phillips, Phoebe, and Ford, Caroline E.

Subjects
body regions
Abstract

Additional file 1 : Supplementary Fig.S1. Correlation between mRNA and protein expression of ROR1 and ROR2 in CPTAC PDAC discovery cohort. A. ROR1 mRNA and protein expression was positively correlated (Pearson���s R=0.25, p=0.005). B. ROR2 mRNA and protein expression was positively correlated (Pearson���s R=0.48, p

Published
2021
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48. ‘I know you shouldn't compare to other people, but I can’t do anything most people can’: Age, family and occupation categorisations in men’s reasoning about their anxiety in an online discussion forum

Author

Drioli-Phillips, Phoebe G., Le Couteur, Amanda, Oxlad, Melissa, Feo, Rebecca, Scholz, Brett, Drioli-Phillips, Phoebe G., Le Couteur, Amanda, Oxlad, Melissa, Feo, Rebecca, and Scholz, Brett

Abstract

Despite its prevalence, men's anxiety is arguably under-researched and poorly understood. The present study explores the reasoning provided by male posters to an online discussion forum about the source of their anxiety. Posts were collected from an Australian anxiety online discussion forum. This study utilises discursive psychology, informed by principles of membership categorisation analysis, to describe how age, occupation and family-related identities can be invoked within common sense reasoning about the source of male anxiety. References to various identity categories were routinely employed by male forum posters in their representations of themselves, in order to describe the source of their anxiety in terms of a contrast between how they are, and how they should be. In examining accounts of anxiety and responses to those accounts, we can trace cultural knowledge about issues regarding men, masculinity and anxiety that those accounts make relevant. Findings illustrate how men's descriptions of the source of their anxiety should be understood as culturally bound and related to expectations and obligations associated with their social context and category memberships. By enhancing understandings of how men describe the source of their anxiety, this study offers insight into improving the identification and engagement of men experiencing anxiety in health services.

Published
2021

49. Men's Talk About Anxiety Online: Constructing an Authentically Anxious Identity Allows Help-Seeking

Author

Drioli-Phillips, Phoebe G., Oxlad, Melissa, LeCouteur, Amanda, Feo, Rebecca, Scholz, Brett, Drioli-Phillips, Phoebe G., Oxlad, Melissa, LeCouteur, Amanda, Feo, Rebecca, and Scholz, Brett

Abstract

Although anxiety disorders are the most prevalent mental health disorder among Australian men, very little is known about men's experiences of living with, and seeking help for, anxiety. This article examines how male users of an online discussion forum for "anxiety" describe their anxiety in their opening posts. Of particular interest is how such descriptions attend to issues of authenticity and the types of support that men appear to be seeking online. Data were taken from one Australian online anxiety discussion forum over a 2-year period and were analyzed using thematic analysis, informed by principles of discursive psychology. The analysis demonstrates that authenticity of posters' anxiety is attended to in four main ways: (a) orienting to a diagnosis, (b) detailing the severity of their anxiety, (c) emphasizing the longevity of their anxiety, and (d) constructing themselves as trouble resistant. The findings suggest that the forum partially functions as a site for authentically anxious identities to be tested by forum users. A fifth theme relates to how those identities appeared to serve a particular function in terms of men's support-seeking behaviors on the forum. This article has clear practical implications for better understanding men's experiences of anxiety and their anxiety-related help-seeking preferences.

Published
2021

50. "My Skill Is Putting on a Mask and Convincing People Not to Look Closer": Silence, Secrecy and Self-Reliance in Men's Accounts of Troubles-Telling in an Online Discussion Forum for Anxiety.

Author

Drioli-Phillips, Phoebe G., Oxlad, Melissa, Scholz, Brett, Lecouteur, Amanda, and Feo, Rebecca

Subjects
*INTERNET forums, *HELP-seeking behavior, *DISCURSIVE psychology, *VIRTUAL communities, *MENTAL illness, *SELF-reliance
Abstract

Although anxiety disorders are the most prevalent mental health disorder in Australia, little is known about men's anxiety help-seeking practices. This study investigates how male users of an online discussion forum accounted for engaging in troubles-telling in an online community. Posts on an online discussion forum written by men who identify as experiencing anxiety were analysed using discursive psychology, through the identification of four interpretative repertoires: (1) orienting to troubles-telling as their purpose for posting, (2) troubles-talk as a necessary form of self-help, (3) the online community as a last resort and (4) anxiety as a hidden, secret experience. Findings demonstrate how men reproduced hegemonic masculine ideals of strength, self-reliance and emotional stoicism, while also sharing their experiences of anxiety online. This research highlights the relevance of masculine social norms in understanding anxiety help-seeking practices, and also illustrates the value of online communities in offering support to men in need. [ABSTRACT FROM AUTHOR]

Published
2022
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