Boisteau E, Lespagnol A, De Tayrac M, Corre S, Perrot A, Rioux-Leclercq N, Martin-Lannerée S, Artru P, Chalabreysse P, Poureau PG, Doucet L, Coupez D, Bennouna J, Bossard C, Coriat R, Beuvon F, Bauguion L, Leclair F, Chautard R, Lecomte T, Guyetant S, Desgrippes R, Grasset D, Lhostis H, Bouhier-Leporrier K, Bibeau F, Edeline J, Galibert MD, and Lièvre A
Background: Low miR-31-3p expression was identified as predictive of anti-EGFR efficacy in RAS-wt mCRC. Primary tumor side was also proposed as a predictive factor of anti-EGFR benefit. This retrospective multicentric study evaluated the predictive role of miR-31-3p in right-sided RAS-wt mCRC patients treated with first-line CT+anti-EGFR or CT+bevacizumab (Beva)., Methods: Seventy-two right-sided RAS-wt mCRC patients treated in first-line with CT+anti-EGFR (n = 43) or Beva (n = 29) were included. Overall survival (OS), progression-free survival (PFS) and response rate (RR) were analyzed and stratified according to tumor miR-31-3p expression level and targeted therapy (TT)., Results: BRAF V600E mutation was more frequent in high vs low miR-31-3p expressers (60.6% vs 15.4%, P < 0.001). PFS was significantly longer with CT+Beva than with CT+anti-EGFR (13 vs 7 months; P = 0.024). Among low miR-31-3p expressers, PFS, OS and RR were not significantly different between the two groups, while in high miR-31-3p expressers, only PFS was longer in the CT+Beva group (11 vs 6 months; P = 0.03). In patients treated with CT+anti-EGFR, low miR-31-3p expressers had a significantly longer OS (20 vs 13 months; P = 0.02) than high miR-31-3p expressers. ORR was not significantly different between the two groups of treatment, in both low and high miR-31-3p expressers. MiR-31-3p expression status was statistically correlated between primary tumors and corresponding metastases., Conclusion: In this study, miR-31-3p couldn't identify a subgroup of patients with right-sided RAS-wt mCRC who might benefit from anti-EGFR and suggest that Beva is the TT of choice in first-line treatment of these patients., Competing Interests: Declaration of Competing Interest EB reports nonfinancial support from Merck Serono, MSD, Sandoz, Amgen, Pfizer. ALespagnol and AP report nonfinancial support from IntegraGen SA. MDT reports nonfinancial support from IntegraGen SA. NRL reports lectures for Astra Zeneca, Pfizer and Bristol Myers Squib. SML declares non financial support from Integragen SA. PA reports board membership for Roche, Amgen, Merck, Pierre Fabre, Servier, and Bayer, with travel funded by Roche, Servier, Amgen, and Pierre Fabre. PGP reports grants, personal fees and nonfinancial support from Servier, nonfinancial support from Novartis, nonfinancial support from Astellas, nonfinancial support from Amgen, nonfinancial support from AbbVie, personal fees and nonfinancial support from Ipsen, personal fees and nonfinancial support from Bayer, and personal fees and nonfinancial support from Sanofi outside the submitted work. JB reports personal fees from Roche, Astra-Zeneca, MSD, Servier, Bayer, and Bristol Myers Squib. TL reports personal fees from Sanofi Genzyme, Merck Serono, Amgen and Servier and nonfinancial support from Amgen and Servier. SG declares personal fees from MSD and AstraZeneca and nonfinancial support from Roche SA, MSD, AstraZeneca and Bristol Myers Squib. DG reports grants from Sanofi Genzyme, Servier, Novartis, Roche. KBLP reports personal fees from IPSEN and Novartis and nonfinancial support from IPSEN. FBibeau reports personal fees from Bristol Myers Squib, MSD, Astra-Zeneca, Merck, Diaceutics, Amgen, and Bayer and nonfinancial support from Bristol Myers Squib and MSD. ALièvre reports grants from Bayer, Lilly, and Novartis; personal fees from AAA, Amgen, Bayer, HalioDx, Incyte, Ipsen, Mylan, Novartis, Pierre Fabre, Roche, Sanofi and Servier; and nonfinancial support from Amgen, Bayer, Boerhinger, Ipsen, Pfizer, Pierre Fabre, Roche, Sandoz, Servier and IntegraGen SA. MDG reports board membership with AZ, Amgen, Pfizer, and Roche and nonfinancial support from IntegraGen SA. PC, LD, DC, CB, RCoriat, FBeuvon, LB, FL, RChautard and RD declare no conflicts of interest., (Copyright © 2022 Elsevier Masson SAS. All rights reserved.)