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2. Regenerating islet-derived protein 3α: A promising therapy for diabetes. Preliminary data in rodents and in humans

Author

Le Lay, Aurélie, Philippe, Erwann, Roth, Fanny, Sanchez-Archidona, Ana Rodriguez, Mehl, Florence, Denom, Jessica, Prasad, Rashmi, Asplund, Olof, Hansson, Ola, Ibberson, Mark, Andreelli, Fabrizio, Santoro, Lyse, Amouyal, Paul, Amouyal, Gilles, Brechot, Christian, Jamot, Laure, Cruciani-Guglielmacci, Céline, and Magnan, Christophe

Published
2022
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5. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice

Author

Laperrousaz, Elise, Moullé, Valentine S., Denis, Raphaël G., Kassis, Nadim, Berland, Chloé, Colsch, Benoit, Fioramonti, Xavier, Philippe, Erwann, Lacombe, Amélie, Vanacker, Charlotte, Butin, Noémie, Bruce, Kimberley D., Wang, Hong, Wang, Yongping, Gao, Yuanqing, Garcia-Caceres, Cristina, Prévot, Vincent, Tschöp, Matthias H., Eckel, Robert H., Le Stunff, Hervé, Luquet, Serge, Magnan, Christophe, and Cruciani-Guglielmacci, Céline

Published
2017
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6. Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

Author

Semplici, Francesca, Mondragon, Angeles, Macintyre, Benedict, Madeyski-Bengston, Katja, Persson-Kry, Anette, Barr, Sara, Ramne, Anna, Marley, Anna, McGinty, James, French, Paul, Soedling, Helen, Yokosuka, Ryohsuke, Gaitan, Julien, Lang, Jochen, Migrenne-Li, Stephanie, Philippe, Erwann, Herrera, Pedro L., Magnan, Christophe, da Silva Xavier, Gabriela, and Rutter, Guy A.

Published
2016
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8. Regenerating Islet-Derived Protein 3α: A Promising Therapy for Diabetes. Preliminary Data in Rodents and in Humans

Author

Le Lay, Aurelie, primary, Philippe, Erwann, additional, Roth, Fanny, additional, Ana Rodriguez Sanchez-Archidona, Ana, additional, Mehl, Florence, additional, Prasad, Rashmi B., additional, Asplund, Olof, additional, Hansson, Ola, additional, Andreelli, Fabrizio, additional, Santoro, Lyse, additional, Amouyal, Paul, additional, Amouyal, Gilles, additional, Brechot, Christian, additional, Jamot, Laure, additional, Cruciani-Guglielmacci, Celine, additional, and Magnan, Christophe, additional

Published
2022
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10. Metabolic benefits of gastric bypass surgery in the mouse: The role of fecal losses

Author

Barataud, Aude, Vily-Petit, Justine, Goncalves, Daisy, Zitoun, Carine, Duchampt, Adeline, Philippe, Erwann, Gautier-Stein, Amandine, Mithieux, Gilles, Di Carlo, Marie-Ange, Nutrition, diabète et cerveau (NUDICE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), and The authors thank the French « Fondation Francophone pour la Recherche sur le Diabète » (2015) and the French « Agence Nationale pour la Recherche » (ANR11-BSV1-016-01 and ANR17-CE14-0007) for funding their work.

Subjects
Male, lcsh:Internal medicine, MC4R, Melanocortin-4 receptor, Gastric Bypass, Metabolic disease, Brief Communication, GTT, Glucose tolerance test, HF-HS, High-fat high-sucrose, Mice, DJB, Duodenal-jejunal bypass, Intestinal gluconeogenesis, PF, Pair-fed, Gastric bypass surgery, Weight Loss, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Obesity, lcsh:RC31-1245, T2DM, Type 2 diabetes mellitus, ITT, insulin tolerance test, RYGB, Roux-en-Y gastric bypass, Body Weight, AUC, Area under the curve, IGN, Intestinal gluconeogenesis, Steatorrhea, Fecal energy loss, GLP-1, Glucagon-like peptide 1, Mice, Inbred C57BL, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], EGA, Enterogastroanastomosis, WT, Wild type
Abstract

Objective Roux-en-Y gastric surgery (RYGB) promotes a rapid and sustained weight loss and amelioration of glucose control in obese patients. A high number of molecular hypotheses were previously tested using duodenal-jejunal bypass (DJB) performed in various genetic models of mice with knockouts for various hormones or receptors. The data were globally negative or inconsistent. Therefore, the mechanisms remained elusive. Intestinal gluconeogenesis is a gut function that has been suggested to contribute to the metabolic benefits of RYGB in obese patients. Methods We studied the effects of DJB on body weight and glucose control in obese mice fed a high fat-high sucrose diet. Wild type mice and mice with a genetic suppression of intestinal gluconeogenesis were studied in parallel using glucose- and insulin-tolerance tests. Fecal losses, including excretion of lipids, were studied from the feces recovered in metabolic cages. Results DJB induced a dramatic decrease in body weight and improvement in glucose control (glucose- and insulin-tolerance) in obese wild type mice fed a high calorie diet, for 25 days after the surgery. The DJB-induced decrease in food intake was transient and resumed to normal in 7–8 days, suggesting that decreased food intake could not account for the benefits. Total fecal losses were about 5 times and lipid losses 7 times higher in DJB-mice than in control (sham-operated and pair-fed) mice, and could account for the weight loss of mice. The results were comparable in mice with suppression of intestinal gluconeogenesis. There was no effect of DJB on food intake, body weight or fecal loss in lean mice fed a normal chow diet. Conclusions DJB in obese mice fed a high calorie diet promotes dramatic fecal loss, which could account for the dramatic weight loss and metabolic benefits observed. This could dominate the effects of the mouse genotype/phenotype. Thus, fecal energy loss should be considered as an essential process contributing to the metabolic benefits of DJB in obese mice., Highlights • Duodenal-jejunal bypass (DJB) promotes weight loss in mice fed a high calorie diet. • DJB induces dramatic fecal energy losses in mice fed a high calorie diet. • DJB has no effect in mice fed a control (starch-based) diet. • There is no fecal losses in DJB-mice fed a control diet. • Fecal energy loss is a cause of body weight loss in DJB-mice fed high calorie diet.

Published
2019
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12. Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions

Author

Bandet, Cécile L., primary, Mahfouz, Rana, additional, Véret, Julien, additional, Sotiropoulos, Athanassia, additional, Poirier, Maxime, additional, Giussani, Paola, additional, Campana, Mélanie, additional, Philippe, Erwann, additional, Blachnio-Zabielska, Agnieszka, additional, Ballaire, Raphaëlle, additional, Le Liepvre, Xavier, additional, Bourron, Olivier, additional, Berkeš, Dušan, additional, Górski, Jan, additional, Ferré, Pascal, additional, Le Stunff, Hervé, additional, Foufelle, Fabienne, additional, and Hajduch, Eric, additional

Published
2018
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15. Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats

Author

UCL - SSS/LDRI - Louvain Drug Research Institute, Vincent, Mylène, Philippe, Erwann, Everard, Amandine, Kassis, Nadim, Rouch, Claude, Denom, Jessica, Takeda, Yorihiko, Uchiyama, Shoji, Delzenne, Nathalie M., Cani, Patrice D., Migrenne, Stéphanie, Magnan, Christophe, UCL - SSS/LDRI - Louvain Drug Research Institute, Vincent, Mylène, Philippe, Erwann, Everard, Amandine, Kassis, Nadim, Rouch, Claude, Denom, Jessica, Takeda, Yorihiko, Uchiyama, Shoji, Delzenne, Nathalie M., Cani, Patrice D., Migrenne, Stéphanie, and Magnan, Christophe

Abstract

Dietary supplement may potentially help to fight obesity and other metabolic disorders such as insulin-resistance and low-grade inflammation. The present study aimed to test whether supplementation with Agaricus blazei murill (ABM) extract could have an effect on diet-induced obesity in rats. Wistar rats were fed with control diet (CD) or high-fat diet (HF) and either with or without supplemented ABM for 20 weeks. HF diet-induced body weight gain and increased fat mass compared to CD. In addition HF-fed rats developed hyperleptinemia and insulinemia as well as insulin resistance and glucose intolerance. In HF-fed rats, visceral adipose tissue also expressed biomarkers of inflammation. ABM supplementation in HF rats had a protective effect against body weight gain and all study related disorders. This was not due to decreased food intake which remained significantly higher in HF rats whether supplemented with ABM or not compared to control. There was also no change in gut microbiota composition in HF supplemented with ABM. Interestingly, ABM supplementation induced an increase in both energy expenditure and locomotor activity which could partially explain its protective effect against diet-induced obesity. In addition a decrease in pancreatic lipase activity is also observed in jejunum of ABM-treated rats suggesting a decrease in lipid absorption. Taken together these data highlight a role for ABM to prevent body weight gain and related disorders in peripheral targets independently of effect in food intake in central nervous system.

Published
2013

16. Fatty Acid Transporter CD36 Mediates Hypothalamic Effect of Fatty Acids on Food Intake in Rats

Author

Moullé, Valentine S., primary, Le Foll, Christelle, additional, Philippe, Erwann, additional, Kassis, Nadim, additional, Rouch, Claude, additional, Marsollier, Nicolas, additional, Bui, Linh-Chi, additional, Guissard, Christophe, additional, Dairou, Julien, additional, Lorsignol, Anne, additional, Pénicaud, Luc, additional, Levin, Barry E., additional, Cruciani-Guglielmacci, Céline, additional, and Magnan, Christophe, additional

Published
2013
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17. Dietary supplementation withAgaricus blazeimurill extract prevents diet-induced obesity and insulin resistance in rats

Author

Vincent, Mylène, primary, Philippe, Erwann, additional, Everard, Amandine, additional, Kassis, Nadim, additional, Rouch, Claude, additional, Denom, Jessica, additional, Takeda, Yorihiko, additional, Uchiyama, Shoji, additional, Delzenne, Nathalie M., additional, Cani, Patrice D., additional, Migrenne, Stéphanie, additional, and Magnan, Christophe, additional

Published
2013
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19. Dietary Supplementation With Agaricus Blazei Murill Extract Prevents Diet-Induced Obesity and Insulin Resistance in Rats

Author

Vincent, Mylène, primary, Philippe, Erwann, additional, Everard, Amandine, additional, Kassis, Nadim, additional, Rouch, Claude, additional, Denom, Jessica, additional, Takeda, Yorihiko, additional, Uchiyama, Shoji, additional, Delzenne, Nathalie M., additional, Cani, Patrice D., additional, Migrenne, Stéphanie, additional, and Magnan, Christophe, additional

Published
2012
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20. Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats.

Author

Vincent, Mylène, Philippe, Erwann, Everard, Amandine, Kassis, Nadim, Rouch, Claude, Denom, Jessica, Takeda, Yorihiko, Uchiyama, Shoji, Delzenne, Nathalie M., Cani, Patrice D., Migrenne, Stéphanie, and Magnan, Christophe

Subjects
DIETARY supplements, AGARICUS, OBESITY treatment, INSULIN resistance, LABORATORY rats, THERAPEUTICS
Abstract

Objective: Dietary supplement may potentially help to fight obesity and other metabolic disorders such as insulin-resistance and low-grade inflammation. The present study aimed to test whether supplementation with Agaricus blazei murill (ABM) extract could have an effect on diet-induced obesity in rats. Design and Methods: Wistar rats were fed with control diet (CD) or high-fat diet (HF) and either with or without supplemented ABM for 20 weeks. Results: HF diet-induced body weight gain and increased fat mass compared to CD. In addition HF-fed rats developed hyperleptinemia and insulinemia as well as insulin resistance and glucose intolerance. In HF-fed rats, visceral adipose tissue also expressed biomarkers of inflammation. ABM supplementation in HF rats had a protective effect against body weight gain and all study related disorders. This was not due to decreased food intake which remained significantly higher in HF rats whether supplemented with ABM or not compared to control. There was also no change in gut microbiota composition in HF supplemented with ABM. Interestingly, ABM supplementation induced an increase in both energy expenditure and locomotor activity which could partially explain its protective effect against diet-induced obesity. In addition a decrease in pancreatic lipase activity is also observed in jejunum of ABM-treated rats suggesting a decrease in lipid absorption. Conclusions: Taken together these data highlight a role for ABM to prevent body weight gain and related disorders in peripheral targets independently of effect in food intake in central nervous system. [ABSTRACT FROM AUTHOR]

Published
2013
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