1. A meta-analysis of remote ischaemic conditioning in experimental stroke
- Author
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Philippa Weir, Saoirse E. O'Sullivan, Timothy J. England, and Ryan Francis Maguire
- Subjects
medicine.medical_specialty ,Ischemia ,Lesion volume ,030204 cardiovascular system & hematology ,Brain Ischemia ,Rats, Sprague-Dawley ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Ischaemic stroke ,Occlusion ,medicine ,Animals ,Ischemic Preconditioning ,Review Articles ,Stroke ,business.industry ,Haplorhini ,Publication bias ,medicine.disease ,Rats ,Disease Models, Animal ,Neurology ,Meta-analysis ,Cardiology ,Conditioning ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Remote ischaemic conditioning (RIC) is achieved by repeated transient ischaemia of a distant organ/limb and is neuroprotective in experimental ischaemic stroke. However, the optimal time and methods of administration are unclear. Systematic review identified relevant preclinical studies; two authors independently extracted data on infarct volume, neurological deficit, RIC method (administration time, site, cycle number, length of limb occlusion (dose)), species and quality. Data were analysed using random effects models; results expressed as standardised mean difference (SMD). In 57 publications incorporating 99 experiments (1406 rats, 101 mice, 14 monkeys), RIC reduced lesion volume in transient (SMD −2.0; 95% CI −2.38, −1.61; p
- Published
- 2020
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