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1. The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)

2. Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors

3. Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist

4. Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

5. Novel N-thiazolyl piperazine-1-carboxamide CCR2 antagonists – investigation of an unexpected reaction with glutathione

6. Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists

7. Species differences in drug plasma protein binding

8. Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists

9. Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors

10. Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

11. Selective non zinc binding inhibitors of MMP13

12. A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions

13. Novel inhibitors of the αvβ3 integrin—lead identification strategy

14. Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat

15. Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation

16. AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models

17. Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40

18. Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Study of Aqueous Solubility, Plasma Protein Binding and Oral Exposure

19. Abstract 5581: Development of 2nd generation indoleamine 2,3-dioxygenase 1 (IDO1) selective inhibitors

20. Activation energies for the decomposition of pharmaceuticals and their application to predicting hydrolytic stability in drug discovery

22. A Putative Monooxygenase Mimic Which Functions via Well-Disguised Free Radical Chemistry1

23. Oxygen activation by metal complexes and alkyl hydroperoxides. Applications of mechanistic probes to explore the role of alkoxyl radicals in alkane functionalization

25. Kinetic Solvent Effects on Hydrogen Atom Abstraction from Phenol, Aniline, and Diphenylamine. The Importance of Hydrogen Bonding on Their Radical-Trapping (Antioxidant) Activities1

26. Correction to Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

27. (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis

28. Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition

30. Novel inhibitors of the alphavbeta3 integrin--lead identification strategy

31. 5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors

32. A simple in vitro assay for assessing the reactivity of nitrile containing compounds

33. A Novel ATM Kinase Inhibitor Effectively Radiosensitizes Glioblastoma in Mice

35. Exploring iron-plus-hydroperoxide based 'oxygen activation' systems. Or: It's hard to keep a good radical down!

36. Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets – the discovery of AZD3651 and AZD9485

37. Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity

38. Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors

39. The Role of Alkoxyl Radicals in Gif (GoAggv) Chemistry

40. The Titanium(IV)-Catalyzed Epoxidation of Alkenes by tert-Alkyl Hydroperoxides

41. Oxadiazole isomers: all bioisosteres are not created equal

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