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There has been a traditional conceptual partition between the so-called non-lesional genetic epilepsies and the genetically determined interposed epileptogenic structural abnormalities. In this review, we summarise how growing evidence acquired through neuroimaging and neurobiology modelling is demonstrating that a distinction between lesional and functional (or non-lesional) epileptogenesis is less obvious than previously thought, particularly for epileptogenic neurodevelopmental disorders, but also for most genetically determined epilepsies. • The distinction between lesional and functional (or non-lesional) epileptogenesis is less progressively fading. • The use of diagnostic gene panels for epileptogenic disorders is at risk of narrowing down molecular testing out of target. • WES is rapidly replacing diagnostic gene panels in the clinical setting. [ABSTRACT FROM AUTHOR]