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1. Serum phospholipids fatty acids and breast cancer risk by pathological subtype

Author

Antonio Antón, Beatriz Pérez-Gómez, Manuel Ramos-Vázquez, Inmaculada Criado-Navarro, Blanca Hernando, Angel Guerrero-Zotano, Raquel Andrés, Rosalia Caballero, Antonio Llombart-Cussac, Ana M. Casas, Miguel Martín, José Manuel Baena-Cañada, Begoña Bermejo, Virginia Lope, Montserrat Muñoz, Feliciano Priego-Capote, Ana de Juan, Adela Castelló, José A. García-Sáenz, Marina Pollán, Rosa María Franquesa, Pedro Sánchez-Rovira, Silvia Antolín, Asociación Española Contra el Cáncer, Sociedad Española de Oncología Médica, Ministerio de Economía y Competitividad (España), Federación Española de Cáncer de Mama, Medicina, Fundación Científica AECC, [Lope,V, Pérez-Gómez,B, Castelló,A, Pollán,M] Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. [Lope,V, Pollán,M] Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain. [Lope,V, Guerrero-Zotano,Á, Casas,A, Baena-Cañada,JM, Bermejo,B, Antolí,S, Sánchez-Rovira,P, Ramos-Vázquez,M, Antón,A, García-Saénz,JÁ, Muñoz,M, de Juan,A, Andrés,R, Llombart-Cussac,A, Hernando,B, Franquesa,RM, Caballero,R, Martín,M, Pollán,M] GEICAM Spanish Breast Cancer Group, Madrid, Spain. [Guerrero-Zotano,Á] Instituto Valenciano de Oncología, Valencia, Spain. [Casas,A] Hospital Universitario Virgen Del Rocio, Sevilla, Spain. [Baena-Cañada,JM] Hospital Universitario Puerta del Mar, Cádiz, Spain. [Baena-Cañada,JM] Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain. [Bermejo,B] Hospital Clínico Universitario de Valencia, Valencia, Spain. [Bermejo,B] Biomedical Research Institute INCLIVA, Valencia, Spain. [Bermejo,B, Martín,M] CIBERONC, ISCIII, Madrid, Spain. [Criado-Navarro,I, Priego-Capote,F] Analytical Chemistry Department, Universidad de Córdoba, Córdoba, Spain. [Criado-Navarro,I, Priego-Capote,F] Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain. [Criado-Navarro,I, Priego-Capote,F] CIBERFES, ISCIII, Madrid, Spain. [Antolín,S] Medical Oncology Unit, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain. [Sánchez-Rovira,P] Complejo Hospitalario de Jaén, Jaén, Spain. [Ramos-Vázquez,M] Centro Oncológico de Galicia, A Coruña, Spain. [Antón,A] Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain. [Castell,A] Faculty of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain. [García-Saénz,JÁ] Hospital Clínico San Carlos, Madrid, Spain. [Muñoz,M] Medical Oncology, Hospital Clínic Barcelona, Barcelona, Spain. [Muñoz,M] Translational Genomics and Targeted Therapeutics, Institut d’Investigacions Biomèdiques Pi i Sunyer-IDIBAPS, Barcelona, Spain. [de Juan,A] Hospital Marqués de Valdecilla, Santander, Spain. [Andrés,R] Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain. [Llombart-Cussac,A] Hospital Arnau de Vilanova, Valencia, Spain. [Hernando,B] Hospital General Yagüe, Burgos, Spain. [Franquesa,RM] Hospital General de Vic, Barcelona, Spain. [Martín,M] Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Martín,M] Instituto Investigación Sanitaria Gregorio Marañón, Universidad Complutense, Madrid, Spain., and This study was funded by the Fundación Científica Asociación Española Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association against Cancer 2006 & 2016), Sociedad Española de Oncología Médica (SEOM) (Spanish Society of Medical Oncology), Ministerio de Economía y Competitividad (Spanish Ministry of Economy and Coiveness. IJCI-2014-20900), Fundación Cerveza y Salud 2005 (Beer and Health Foundation 2005) and Federación de Asociaciones de Mujeres con Cáncer de Mama (FECMA) (Spanish Federation of Associations of Women with Breast Cancer). This article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health.

Subjects
0301 basic medicine, Àcids grassos, Grasas, Gastroenterology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Fats, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, EpiGEICAM, Surveys and Questionnaires, Fosfolípidos, Palmitoleic acid, Ácidos grasos, Phospholipids, desaturation indices, Nutrition and Dietetics, Estudios de casos y controles, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings], Breast neoplasm, Fatty Acids, Chemicals and Drugs::Lipids::Fatty Acids [Medical Subject Headings], Middle Aged, Elaidic acid, 030220 oncology & carcinogenesis, Neoplasias de la mama, Female, Stearic acid, Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological [Medical Subject Headings], lcsh:Nutrition. Foods and food supply, Adult, Risk, medicine.medical_specialty, fats, Phenomena and Processes::Mathematical Concepts::Probability::Risk [Medical Subject Headings], Linoleic acid, Breast cancer subtypes, Breast Neoplasms, lcsh:TX341-641, Desaturation indices, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior [Medical Subject Headings], Article, Information Science::Information Science::Data Collection::Questionnaires [Medical Subject Headings], Càncer de mama, 03 medical and health sciences, breast neoplasm, Internal medicine, Biomarkers, Tumor, medicine, Humans, Fatty acids, Persons::Persons::Age Groups::Adult [Medical Subject Headings], Chemicals and Drugs::Lipids::Phospholipids [Medical Subject Headings], Life Style, Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings], Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Feeding Behavior, Odds ratio, medicine.disease, Confidence interval, breast cancer subtypes, 030104 developmental biology, Check Tags::Female [Medical Subject Headings], chemistry, Spain, Case-Control Studies, business, Body mass index, Food Science
Abstract

This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44, 95% confidence interval (CI) = 0.30&ndash, 0.66), linoleic acid (ORT3vsT1 = 0.66, 95% CI = 0.49&ndash, 0.90) and arachidonic to dihomo-&gamma, linolenic acid ratio (OR T3vsT1 = 0.64, 95% CI = 0.48&ndash, 0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65, 95% CI = 1.20&ndash, 2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51, 95% CI = 1.12&ndash, 2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52, 95% CI = 1.14&ndash, 2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04, 95% CI = 1.45&ndash, 2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.

Published
2020

2. Photoletter to the editor: Response of linear porokeratosis to photodynamic therapy in an 11-year-old girl

Author

Garrido-Colmenero, Cristina, Ruiz-Villaverde, Ricardo, Martínez-García, Eliseo, Aneiros-Fernández, José, Tercedor-Sánchez, Jesús, [Garrido-Colmenero,C, Ruiz-Villaverde,R, Martínez-García,E, and Tercedor-Sánchez,J] Department of Dermatology, Virgen de las Nieves Hospital, Granada, Spain. [Aneiros-Fernández,J] Pathology Department, Virgen de las Nieves Hospital. Granada, Spain.

Subjects
Enfermedades de la piel, Phenomena and Processes::Mathematical Concepts::Probability::Risk [Medical Subject Headings], Diseases::Skin and Connective Tissue Diseases::Skin Diseases [Medical Subject Headings], Fotoquimioterapia, Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Keratosis::Porokeratosis [Medical Subject Headings], Phenomena and Processes::Integumentary System Physiological Phenomena::Skin Physiological Phenomena [Medical Subject Headings], Diseases::Neoplasms [Medical Subject Headings], Riesgo, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Phototherapy::Photochemotherapy [Medical Subject Headings], Neoplasias, Porokeratosis, Treatment, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Poroqueratosis, Fenómenos Fisiológicos de la Piel, Pathology, Child
Abstract

Journal Article; Porokeratoses are a group of different entities that belong to the skin keratinization disorders. From the histological point of view the main and common characteristic of these disorders is the presence of compact parakeratotic columns known as cornoid lamellae. All varieties should be carefully treated and followed-up because of the risk of developing malignant epithelial tumors. We report the successful response to photodynamic therapy (PDT) in a pediatric patient diagnosed with linear porokeratosis. Yes

Published
2015

3. Polymorphisms in endothelin system genes, arsenic levels and obesity risk

Author

Inmaculada Galan-Chilet, David Morchon, Sonsoles Morcillo, Sergio Martínez-Hervás, Juan F. Ascaso, Felipe J. Chaves, Juan Carlos Martín-Escudero, Griselda de Marco, José T. Real, Vanesa Martínez-Barquero, Gemma Rojo, Pilar Rentero, Sebastian Blesa, [Martínez-Barquero,V, Martínez-Hervas,S, Ascaso,JF, Real,JT] Department of Medicine, University of Valencia, Valencia, Spain. [Martínez-Barquero,V, de Marco,G, Rentero,P, Galan-Chilet,I, Blesa,S, Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Hospital Clínico Research Foundation (INCLIVA), Valencia, Spain. [Martínez-Hervas,S, Morcillo,S, Rojo,G, Real,JT, Chaves,FJ] CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain. [Morcillo,S, Rojo G] Service of Endocrinology and Nutrition, Hospital Regional Universitario, Málaga, Spain, Instituto de Biomedicina de Málaga (IBIMA), Málaga, Spain. [Martínez-Hervas,S, Real, JT] Service of Endocrinology and Nutrition, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Morchon,D, Martín-Escudero,JC] Internal Medicine, Rio Hortega Hospital, University of Valladolid, Valladolid, Spain., This work was supported by the funds for research in health sciences from Carlos III Health Institute (PI07/0497 and PI11/00726), by CIBER de Diabetes y Enfermedades Metabólicas Relacionadas (CIBERDEM), and CIBERDEM is an initiative by Carlos III Health Institute in Madrid and the Spanish Health Ministry, by PROMETEO/2009/029, AP-091/11, and ACOMP/2013/039 from the Valencian Government, and by GRS 279/a/08 research project from JUNTA DE CASTILLA Y LEON Government.

Subjects
Male, España, Obesidad, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Fat Distribution::Adiposity [Medical Subject Headings], Endothelins, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Endothelins [Medical Subject Headings], Polymorphism (computer science), Risk Factors, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity [Medical Subject Headings], Chemicals and Drugs::Inorganic Chemicals::Elements::Arsenic [Medical Subject Headings], Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], education.field_of_study, Multidisciplinary, Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings], Genètica humana, Middle Aged, Prognosis, Receptor, Endothelin A, Polimorfismo de nucleótido único, Anatomy::Cells::Connective Tissue Cells::Adipocytes [Medical Subject Headings], Obesitat, Medicine, Female, Tomografía computarizada por rayos X, Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], Endothelin receptor, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation, Computer-Assisted::Tomography, X-Ray Computed [Medical Subject Headings], Research Article, medicine.hormone, medicine.medical_specialty, Genotype, Phenomena and Processes::Mathematical Concepts::Probability::Risk [Medical Subject Headings], Science, Population, Single-nucleotide polymorphism, Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism::Lipolysis [Medical Subject Headings], Biology, Polymorphism, Single Nucleotide, Arsenic, Receptores de endotelinas, Internal medicine, Adipocitos, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Peptide::Receptors, Endothelin [Medical Subject Headings], medicine, Humans, Genetic Predisposition to Disease, Obesity, education, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide [Medical Subject Headings], Adiponectin, Haplotype, Enfermedad crónica, medicine.disease, Endocrinology, Haplotypes, Spain, Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Adipokines::Adiponectin [Medical Subject Headings], Genotipo, Follow-Up Studies, Arsénico
Abstract

Background/objectivesObesity has been linked to morbidity and mortality through increased risk for many chronic diseases. Endothelin (EDN) system has been related to endothelial function but it can be involved in lipid metabolism regulation: Receptor type A (EDNRA) activates lipolysis in adipocytes, the two endothelin receptors mediate arsenic-stimulated adipocyte dysfunction, and endothelin system can regulate adiposity by modulating adiponectin activity in different situations and, therefore, influence obesity development. The aim of the present study was to analyze if single nucleotide polymorphisms (SNPs) in the EDN system could be associated with human obesity.Subjects/methodsWe analyzed two samples of general-population-based studies from two different regions of Spain: the VALCAR Study, 468 subjects from the area of Valencia, and the Hortega Study, 1502 subjects from the area of Valladolid. Eighteen SNPs throughout five genes were analyzed using SNPlex.ResultsWe found associations for two polymorphisms of the EDNRB gene which codifies for EDN receptor type B. Genotypes AG and AA of the rs5351 were associated with a lower risk for obesity in the VALCAR sample (p=0.048, OR=0.63) and in the Hortega sample (p=0.001, OR=0.62). Moreover, in the rs3759475 polymorphism, genotypes CT and TT were also associated with lower risk for obesity in the Hortega sample (p=0.0037, OR=0.66) and in the VALCAR sample we found the same tendency (p=0.12, OR=0.70). Furthermore, upon studying the pooled population, we found a stronger association with obesity (p=0.0001, OR=0.61 and p=0.0008, OR=0.66 for rs5351 and rs3759475, respectively). Regarding plasma arsenic levels, we have found a positive association for the two SNPs studied with obesity risk in individuals with higher arsenic levels in plasma: rs5351 (p=0.0054, OR=0.51) and rs3759475 (p=0.009, OR=0.53).ConclusionsOur results support the hypothesis that polymorphisms of the EDNRB gene may influence the susceptibility to obesity and can interact with plasma arsenic levels.

Published
2015

4. Dectin-1 and DC-SIGN Polymorphisms Associated with Invasive Pulmonary Aspergillosis Infection

Author

Asta Försti, Salvador Oyonarte, Carmen Belén Lupiañez, Lourdes Vazquez, Manuel Jurado, Juan Sainz, Juana Segura-Catena, Kari Hemminki, Rafael Rios, [Sainz,J, Lupiáñez,CB, Segura-Catena,J, Ríos,R, Jurado,M] Genomic Oncology Area, Genyo (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain. [Sainz,J, Hemminki,K, Försti, A] Molecular Genetic Epidemiology Department, German Cancer Research Center, Heidelberg, Germany. [Sainz,J, Jurado,M] Haematology Department, University Hospital Virgen de las Nieves, Granada,Spain. [Vazquez,L] Hematology Department, University Hospital of Salamanca, Salamanca, Spain. [Oyonarte,S] Blood Transfusion Regional Centre and Sectorial Tissue Bank, Granada, Spain. [Hemminki,K, Försti,A] Center for Primary Health Care Research, Clinical Research Center, Malmö, Sweden., and This study was supported by grants P08-CVI-4116 from Consejeríaa de Salud de la Junta de Andalucia (Sevilla, Spain) and PI081051 from Fondo de Investigaciones Sanitarias (Madrid, Spain).

Subjects
Male, Epidemiology, Enfermedades Pulmonares Fúngicas, Diseases::Bacterial Infections and Mycoses::Mycoses::Hyalohyphomycosis::Aspergillosis [Medical Subject Headings], lcsh:Medicine, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Aspergillosis, Polymerase Chain Reaction, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mannans, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Membrane Glycoproteins::Cell Adhesion Molecules [Medical Subject Headings], Genotype, Molecular Cell Biology, Odds Ratio, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Odds Ratio [Medical Subject Headings], lcsh:Science, Genetics, Multidisciplinary, Lectinas Tipo C, Fungal genetics, Fungal Diseases, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, Organisms::Eukaryota::Fungi::Mitosporic Fungi::Aspergillus::Aspergillus fumigatus [Medical Subject Headings], Infectious Diseases, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunoassay::Immunoenzyme Techniques::Enzyme-Linked Immunosorbent Assay [Medical Subject Headings], Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings], Medicine, Female, Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface [Medical Subject Headings], Research Article, Adult, Risk, Adolescent, Phenomena and Processes::Mathematical Concepts::Probability::Risk [Medical Subject Headings], Receptores de Superficie Celular, Polimorfismo Genético, Diseases::Bacterial Infections and Mycoses::Mycoses::Lung Diseases, Fungal [Medical Subject Headings], Check Tags::Male [Medical Subject Headings], Single-nucleotide polymorphism, Enzyme-Linked Immunosorbent Assay, Receptors, Cell Surface, Biology, Polymorphism, Single Nucleotide, Molecular Genetics, Chemicals and Drugs::Carbohydrates::Polysaccharides::Mannans [Medical Subject Headings], Genetic variation, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], medicine, Humans, Lectins, C-Type, Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Allele, Genetic association, Aged, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide [Medical Subject Headings], Polymorphism, Genetic, Lung Diseases, Fungal, Aspergillus fumigatus, lcsh:R, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Lectins::Lectins, C-Type [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction [Medical Subject Headings], Galactose, Odds ratio, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic [Medical Subject Headings], medicine.disease, Ensayo de Inmunoadsorción Enzimática, Mananos, Aspergilosis, Check Tags::Female [Medical Subject Headings], Immunology, Reacción en Cadena de la Polimerasa, Moléculas de Adhesión Celular, lcsh:Q, Polimorfismo de Nucleótido Simple, Cell Adhesion Molecules, Population Genetics
Abstract

Journal Article; Research Support, Non-U.S. Gov't; The recognition of pathogen-derived structures by C-type lectins and the chemotactic activity mediated by the CCL2/CCR2 axis are critical steps in determining the host immune response to fungi. The present study was designed to investigate whether the presence of single nucleotide polymorphisms (SNPs) within DC-SIGN, Dectin-1, Dectin-2, CCL2 and CCR2 genes influence the risk of developing Invasive Pulmonary Aspergillosis (IPA). Twenty-seven SNPs were selected using a hybrid functional/tagging approach and genotyped in 182 haematological patients, fifty-seven of them diagnosed with proven or probable IPA according to the 2008 EORTC/MSG criteria. Association analysis revealed that carriers of the Dectin-1(rs3901533 T/T) and Dectin-1(rs7309123 G/G) genotypes and DC-SIGN(rs4804800 G), DC-SIGN(rs11465384 T), DC-SIGN(7248637 A) and DC-SIGN(7252229 C) alleles had a significantly increased risk of IPA infection (OR = 5.59 95%CI 1.37-22.77; OR = 4.91 95%CI 1.52-15.89; OR = 2.75 95%CI 1.27-5.95; OR = 2.70 95%CI 1.24-5.90; OR = 2.39 95%CI 1.09-5.22 and OR = 2.05 95%CI 1.00-4.22, respectively). There was also a significantly increased frequency of galactomannan positivity among patients carrying the Dectin-1(rs3901533_T) allele and Dectin-1(rs7309123_G/G) genotype. In addition, healthy individuals with this latter genotype showed a significantly decreased level of Dectin-1 mRNA expression compared to C-allele carriers, suggesting a role of the Dectin-1(rs7309123) polymorphism in determining the levels of Dectin-1 and, consequently, the level of susceptibility to IPA infection. SNP-SNP interaction (epistasis) analysis revealed significant interactions models including SNPs in Dectin-1, Dectin-2, CCL2 and CCR2 genes, with synergistic genetic effects. Although these results need to be further validated in larger cohorts, they suggest that Dectin-1, DC-SIGN, Dectin-2, CCL2 and CCR2 genetic variants influence the risk of IPA infection and might be useful in developing a risk-adapted prophylaxis. Yes

Published
2012
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5. Guillain-Barré syndrome following the 2009 pandemic monovalent and seasonal trivalent influenza vaccination campaigns in Spain from 2009 to 2011: outcomes from active surveillance by a neurologist network, and records from a country-wide hospital discharge database

Author

Alcalde Cabero, Enrique, Almazan Isla, Javier, García López, Fernando J., Ara Callizo, José Ramón, Avellanal, Fuencisla, Casasnovas Pons, Carlos, Cemillán, Carlos, Cuadrado, José Ignacio, Duarte, Jacinto, Fernández Pérez, María Dolores, Fernández, Óscar, García Merino, Juan Antonio, García Montero, Rosa, Montero, Dolores, Pardo, Julio, Rodríguez Rivera, Francisco Javier, Ruiz Tovar, María, Pedro Cuesta, Jesús de, Spanish GBS Epidemiology Study Group, Universitat de Barcelona, Spanish GBS Epidemiology Study Group, [Alcalde-Cabero,E, Almazán-Isla,J, García López,FJ, Avellanal,F, Ruiz Tovar,M, and de Pedro-Cuesta,J] National Centre for Epidemiology, CIBERNED, Carlos III Health Institute, Madrid, Spain. [Ara-Callizo,JR] Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain. [Casasnovas,C] Neuromuscular Unit, Neurology Department, Bellvitge University Hospital, Bellvitge. Biomedical Research Institute (Institut d’Investigació Biomèdica de Bellvitge/IDIBELL), L’Hospitalet de Llobregat, Spain. [Cemillán,C] Neurology Department, Severo Ochoa University Hospital, Leganés, Madrid, Spain. [Cuadrado,JI] Epidemiology Department, Regional Ministry of Health, Madrid Autonomous Region, Spain. [Duarte,J] Neurology Department, General Hospital, Segovia, Spain. [Fernández-Pérez,MD] Neurology Department, Virgen de las Nieves University Hospital, Granada, Spain. [Fernández,O] Neurology Department, Carlos Haya University Hospital, Málaga, Spain. [García Merino,JA] Neurology Department, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain. [García Montero,R] Neurology Department, Virgen de la Salud Hospital, Toledo, Spain. [Montero,D] Spanish Medicines & Medical Devices Agency (Agencia Española de Medicamentos y Productos Sanitarios), Madrid, Spain. [Pardo,J] Neurology Department, University Teaching Hospital Clínico, Santiago de Compostela (Corunna), Spain. [Rodríguez-Rivera,FJ] Neurology Department, La Paz University Hospital, Madrid, Spain.

Subjects
Male, Pediatrics, Hospitales generales, Time Factors, Síndrome de Guillain-Barré, Databases, Factual, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], Autoimmune diseases, España, Vacunas contra la influenza, Proyectos piloto, ICD-9-CM, Vacunes, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, Public health surveillance, Estudios prospectivos, Pandemic, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunization [Medical Subject Headings], Peripheral nerves, Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Vaccines, Guillain-Barre syndrome, Malalties autoimmunitàries, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals::Hospitals, General [Medical Subject Headings], Incidence (epidemiology), Incidence, virus diseases, Síndrome de Miller Fisher, General Medicine, Middle Aged, Guillain-Barré syndrome, Phenomena and Processes::Physical Phenomena::Time::Periodicity::Seasons [Medical Subject Headings], Vaccination, Influenza vaccines, Chemicals and Drugs::Complex Mixtures::Biological Agents::Vaccines::Viral Vaccines::Influenza Vaccines [Medical Subject Headings], Inmunización, Epidemiological Monitoring, Sistema de registros, Female, Disciplines and Occupations::Health Occupations::Medicine::Neurology [Medical Subject Headings], Safety, Incidencia, Research Article, Subtipo H1N1 del virus de la influenza A, Trivalent influenza vaccine, Adult, Information Science::Information Science::Information Services::Documentation::Vocabulary, Controlled::International Classification of Diseases [Medical Subject Headings], medicine.medical_specialty, Phenomena and Processes::Mathematical Concepts::Probability::Risk [Medical Subject Headings], Clinical Neurology, Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebellar Diseases::Miller Fisher Syndrome [Medical Subject Headings], Nervis perifèrics, Estaciones del año, Guillain-Barre Syndrome, Riesgo, Influenzavirus, Clasificación internacional de enfermedades, Grip, Estudios retrospectivos, 03 medical and health sciences, Neuritis, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings], Organisms::Viruses::RNA Viruses::Orthomyxoviridae::Influenzavirus A::Influenza A virus::Influenza A Virus, H1N1 Subtype [Medical Subject Headings], Gripe Humana, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], medicine, Humans, Influenza viruses, Neurologists, Diseases::Nervous System Diseases::Neuromuscular Diseases::Peripheral Nervous System Diseases::Neuritis [Medical Subject Headings], Intensive care medicine, Pandemics, Aged, Retrospective Studies, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Pilot Projects [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy::Immunization::Immunotherapy, Active::Vaccination [Medical Subject Headings], business.industry, Vacunación, Retrospective cohort study, medicine.disease, Diseases::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Polyradiculoneuropathy::Guillain-Barre Syndrome [Medical Subject Headings], Influenza, Spain, Influenza A virus H1N1 subtype, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings], Neurology (clinical), Diseases::Virus Diseases::RNA Virus Infections::Orthomyxoviridae Infections::Influenza, Human [Medical Subject Headings], business, 030217 neurology & neurosurgery
Abstract

BACKGROUND: Studies have shown a slight excess risk in Guillain-Barré syndrome (GBS) incidence associated with A(H1N1)pdm09 vaccination campaign and seasonal trivalent influenza vaccine immunisations in 2009-2010. We aimed to assess the incidence of GBS as a potential adverse effect of A(H1N1)pdm09 vaccination. METHODS: A neurologist-led network, active at the neurology departments of ten general hospitals serving an adult population of 4.68 million, conducted GBS surveillance in Spain in 2009-2011. The network, established in 1996, carried out a retrospective and a prospective study to estimate monthly alarm thresholds in GBS incidence and tested them in 1998-1999 in a pilot study. Such incidence thresholds additionally to observation of GBS cases with immunisation antecedent in the 42 days prior to clinical onset were taken as alarm signals for 2009-2011, since November 2009 onwards. For purpose of surveillance, in 2009 we updated both the available centres and the populations served by the network. We also did a retrospective countrywide review of hospital-discharged patients having ICD-9-CM code 357.0 (acute infective polyneuritis) as their principal diagnosis from January 2009 to December 2011. RESULTS: Among 141 confirmed of 148 notified cases of GBS or Miller-Fisher syndrome, Brighton 1-2 criteria in 96 %, not a single patient was identified with clinical onset during the 42-day time interval following A(H1N1)pdm09 vaccination. In contrast, seven cases were seen during a similar period after seasonal campaigns. Monthly incidence figures did not, however, exceed the upper 95 % CI limit of expected incidence. A retrospective countrywide review of the registry of hospital-discharged patients having ICD-9-CM code 357.0 (acute infective polyneuritis) as their principal diagnosis did not suggest higher admission rates in critical months across the period December 2009-February 2010. CONCLUSIONS: Despite limited power and underlying reporting bias in 2010-2011, an increase in GBS incidence over background GBS, associated with A(H1N1)pdm09 monovalent or trivalent influenza immunisations, appears unlikely Sí

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